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小泉知展  コイズミ トモノブ

教員組織学術研究院(医学系)電話番号
教育組織医学部 医学科 包括的がん治療学FAX番号
職名教授メールアドレス
住所ホームページURL

更新日:2019/07/29

プロフィール

研究分野
呼吸器病学
現在の研究課題
肺癌

各悪性腫瘍の治療
キーワード:化学療法
急性肺損傷

所属学会
所属学会
日本内科学会
日本呼吸器学会
日本肺癌学会
日本呼吸器内視鏡学会
日本臨床腫瘍学会
Asia Pacific Society of Respirology
American Society of Clinical Oncology
学歴
出身学校・専攻等(大学院を除く)
1985 , 信州大学 , 医学部

取得学位
医学博士

研究活動業績

研究業績(著書・
発表論文等)
論文
「健康寿命延伸ボックス」を用いたがん化学療法の毒性軽減効果
信州医学雑誌,67(2):105-111 2019(Apr. 10)
Author:宮川 真理子、野口 卓郎、福嶋 敏郎、小沢 岳澄、小林 孝至、関口 和、間宮 敬子、小泉 知展、内川 順子


Successful Salvage Chemotherapy with Mediastinal Atypical Carcinoid Tumor Who Had Relapsed after Various Prior Therapies
Case Rep Oncol,11:49-54 2018
Author:Fukushima T, Gomi D, Seno N, Gibo T, Kobayashi T, Sekiguchi N, Matsushita H, Kasahara Y, Mamiya K, Koizumi T


Phase II study of cisplatin/pemetrexed combined with bevacizumab followed by pemetrexed/bevacizumab maintenance therapy in patients with EGFR-wild advanced non-squamous non-small cell lung cancer
Cancer Chemother Pharmacol,81(6):1043-1050 2018
Author:Fukushima T, Wakatsuki Y, Kobayashi T, Sonehara K, Tateishi K, Yamamoto M, Masubuchi T, Yoshiike F, Hirai K, Hachiya T, Koizumi T


Gastric cancer initially presenting as bone metastasis: Two case reports and a literature review
Oncol Lett,16:5863-5867 2018
Author:Gomi D, Fukushima T, Kobayashi T, Sekiguchi N, Sakamoto A, Mamiya K, Koizumi T


Signet Ring Cell Carcinoma of Unknown Primary Origin Detected Incidentally by Lymph Node Purification for Thyroid Carcinoma
Intern Med,57(1):31-35 2018
Author:Handa H, Gomi D, Fukushima T, Kobayashi T, Sekiguchi N, Sakamoto A, Tsukahara Y, Matsushita H, Sasaki S, Mamiya K, Koizumi T, Ichiyama T


Salivary cytokine panel indicative of non-small cell lung cancer
J Int Med Res,46(9):3570-3582 2018
Author:Koizumi T, Shetty V, Yamaguchi M


Development of angiosarcoma in a mediastinal non-seminomatous germ cell tumor that exhibited growing teratoma syndrome during chemotherapy
Thoracic Cancer,10(1):111-115 2018
Author:Matsuoka S, Koyama T, Takeda T, Yamada K, Hyogotani A, Hamanaka K, Sekiguchi N, Koizumi T


Primary Mediastinal dedifferentiated liposarcoma: Five case reports and a review
Thorac Cancer,9(12):1733-1740 2018
Author:Miura K, Hamanaka K, Matsuoka S, Takeda T, Agatsuma H, Hyogatani A, Ito K, Nishimaki F, Koizumi T, Uehara T


Chemotherapy for advanced and metastatic thymic carcinoma
Mediastinum,2:52 2018
Author:Noguchi T, Koizumi T


Serum 5-S-cysteinyldopa behavior in the early phase of nivolumab treatment of 12 melanoma patients
J Dermatol,45:1340-1344 2018
Author:Omodaka T, Minagawa A, Uhara H, Wakamatsu K, Koizumi T, Yokokawa Y, Koga H, Okuyama R


Intradiaphragmatic Bronchogenic Cysts: A Case Report and Literature Review
OMICS J Radiol,7(1):1000289 2018
Author:Sekiguchi N, Gomi D, Noguchi T, Kobayashi T, Koizumi T, Fujita A, Kawakami S


WT1-pulsed Dendritic Cell Vaccine Combined with Chemotherapy for Resected Pancreatic Cancer in a Phase I Study
Anticancer Res,38(4):2217-2225 2018
Author:Yanagisawa R, Koizumi T, Koya T, Sano K, Koido S, Nagai K, Kobayashi M, Okamoto M, Sugiyama H, Shimodaira S


Frequent STAT3 mutations in CD8+ T cells from patients with pure red cell aplasia
Blood Adv,2(20):1704-1712 2018
Author:Kawakami T, Sekiguchi N, Kobayashi J, Imi T, Matsuda K, Yamane T, Nishina S, Senoo Y, Sakai H, Ito T, Koizumi T, Hirokawa M, Nakao S, Nakazawa H, Ishida F


Self-assessment of Allergic Rhinitis and Asthma (SACRA) Questionnaire-based Allergic Rhinitis Treatment Improves Asthma Control in Asthmatic Patients with Allergic Rhinitis
Intern Med,56(1):31-39 2017
Author:Yasuo M, Kitaguchi Y, Komatsu Y, Hama M, Koizumi T, Agatsuma T, Ichiyama T, Kato A, Moteki H, Hanaoka M


Successful treatment with doxorubicin and ifosfamide for mediastinal malignant peripheral nerve sheath tumor with loss of H3K27me3 expression
Thorac Cancer,8(6):720-723 2017
Author:Seno N, Fukushima T, Gomi D, Kobayashi T, Sekiguchi N, Matsushita H, Ozawa T, Tsukahara Y, Mamiya K, Koizumi T, Sano K


Oral cyclophosphamide was effective for Coombs-negative autoimmune hemolytic anemia in CD16+CD56- chronic lymphoproliferative disorder of NK-cells
Int J Hematol,105(6):854-858 2017
Author:Sekiguchi N, Nishina S, Kawakami T, Sakai H, Senoo N, Senoo Y, Ito T, Saito H, Nakazawa H, Koizumi T, Ishida F


Plasma L-carnitine levels in terminally ill cancer patients receiving only palliative care
Ann Palliat Med,6(1):52-57 2017
Author:Sakamoto A, Tsukahara Y, Gomi D, Fukushima T, Kobayashi T, Matsushita H, Sekiguchi N, Mamiya K, Koizumi T


Initial clinical presentation of single soft tissue metastasis of medullary thyroid carcinoma without primary rumor in the thyroid gland
World J Surg Oncol,15(1):221 2017
Author:Okamoto M, Takazawa A, Aoki K, Yoshimura Y, Kato H, Otsuki T, Maeno K, Koizumi T


Anamorelin for advanced non-small-cell lung cancer with cachexia: Systematic review and meta-analysis
Lung Cancer,112:25-34 2017
Author:Nishie K, Yamamoto S, Nagata C, Koizumi T, Hanaoka M


Successful Resection of G719X-Positive Pleomorphic Carcinoma after Afatinib Treatment
Case Rep Oncol,DOI: 10.1159/000480120 2017
Author:Nakamura D, Miura K, Kumeda H, Agatsuma H, Hyogotani A, Hamanaka K, Koizumi T, Yamamoto H, Tamada H, Ito K


Clinical significance of preoperative serum albumin level for prognosis in surgically resected patients with non-small cell lung cancer: Comparative study of normal lung, emphysema, and pulmonary fibrosis
Lung Cancer,111:88-95 2017
Author:Miura K, Hamanaka K, Koizumi T, Kitaguchi Y, Terada Y, Nakamura D, Kumeda H, Agatsuma H, Hyogotani A, Kawakami S, Yoshizawa A, Asaka S, Ito K


Relapsed and unresectable inflammatory myofibroblastic tumor responded to chemotherapy: A case report and review of the literature
Mol Clin Oncol,7:521-524 2017
Author:Maruyama Y, Fukushima T, Gomi D, Kobayashi T, Sekiguchi N, Sakamoto A, Sasaki S, Mamiya K, Koizumi T


Correlation of early PET findings with tumor response to molecular targeted agents in patients with advanced driver-mutated non-small cell lung cancer
Med Oncol,34(10):169 2017
Author:Koizumi T, Fukushima T, Gomi D, Kobayashi T, Sekiguchi N, Mamiya K, Tateishi K, Katou A, Oguchi K


Successful and long-term response to trastuzumab plus paclitaxel combination therapy in human epidermal growth factor receptor 2-positive extramammary Paget's disease: A case report and review of the literature
Mol Clin Oncol,7:763-766 2017
Author:Ichiyama T, Gomi D, Fukushima T, Kobayashi T, Sekiguchi N, Sakamoto A, Sasaki S, Mamiya K, Koizumi T, Hama Y


Dynamics of L-Carnitine in Plasma and Urine in Patients Undergoing Cisplatin Chemotherapy
Chemotherapy,62(4):225-230 2017
Author:Gomi D, Tanaka A, Fukushima T, Kobayashi T, Matsushita H, Sekiguchi N, Sakamoto A, Sasaki S, Mamiya K, Koizumi T


がん診療連携拠点病院の院内がん登録からみた長野県のがん状況第一報
信州医学雑誌,64(1):21-27 2016
Author:齋藤知子、野澤早加、小泉知展


Clinical analysis of patients treated with afatinib for advanced non-small cell lung cancer: A Nagano Lung Cancer Research Group observational study
Respir Investig,54(6):462-467 2016
Author:Wada Y, Koyama S, Kuraishi H, Miyahara T, Yoshiike F, Agatsuma T, Yamamoto R, Ono Y, Suzuki T, Hachiya T, Gomi D, Tateishi K, Hanaoka M, Koizumi T


Effectiveness of Imatinib Mesylate Treatment in a Patient with Dermatofibrosarcoma Protuberans with Pulmonary and Pancreatic Metastases
Intern Med,55(17):2507-2511 2016
Author:Tatai T, Gomi D, Fukushima T, Kobayashi T, Sekiguchi N, Sakamoto A, Sasaki S, Koizumi T, Sano K


Opioid withdrawal presenting only nausea during tapering of oxycodone after celiac plexus block: a case report
Ann Palliat Med,5(1):67-70 2016
Author:Sakamoto A, Takayama H, Mamiya K, Koizumi T


Development of combined thymic carcinoma and thymoma in an extrathymic lesion during long follow-up for recurrent thymoma
Mol Clin Onc,4(2):139-142 2016
Author:Ohue Y, Matsuoka S, Kumeda H, Agatsuma H, Hyougotani A, Toishi M, Shiina T, Yoshida K, Shingu K, Fukushima T, Koizumi T


Early-onset colorectal cancer in young adult survivors of childhood cancer
Pediatr Int,58(7):637-639 2016
Author:Morita D, Nakazawa Y, Tanaka M, Nakayama Y, KoizumiT, Koike K


Alectinib-Induced Alopecia in a Patient with Anaplstic Lymphoma Kinase-Positive Non-Small Cell Lung Cancer
Cace Rep Oncol,9:212-215 2016
Author:Koizumi T, Fukushima T, Gomi D, Kobayashi T, Sekiguchi N, Sakamoto A, Sasaki S, Mamiya K


A Case of Olfactory Neuroblastoma (Esthesioneuroblastoma) Presenting with Anemia Due to Nasal Bleeding
Shinshu Medical Journal,64(5):247-252 2016
Author:Gomi D, Sasaki S, Sekiguchi N, Kobayashi T, Sakamoto A, Koizumi T


Inhibition of epidermal growth factor receptor induces tumor necrosis factor-α via activation of peroxisome proliferator-activated receptor-γ and nuclear factor-κB in sebocytes: A possible pathogenesis of papulopustular rash
J Dermatol Sci,82(1):53-56 2016
Author:Ashida A, Ogawa E, Uhara H, Koizumi T, Okuyama R


《調査報告》がん化学療法施行中の患者が抱える性生活の変化と相談行動
がん看護,20(3):395-399 2015
Author:所真由美、池田美恵、塩原真弓、小泉知展、伊藤研一


Iris Metastasis of Esophageal Cancer
Intern Med,54:1941 2015
Author:Tatai T, Sasaki S, Sekiguchi N, Koizumi T


Dendritic Cell-Based Adjuvant Vaccination Targeting Wilms’Tumor 1 in Patients with Advanced Colorectal Cancer
Vaccines,3(4):1004-1018 2015
Author:Shimodaira S, Sano K, Hirabayashi K, Koya T, Higuchi Y, Mizuno Y, Yamaoka N, Yuzawa M, Kobayashi T, Ito K, Koizumi T


Induction of Antigen-Specific Cytotoxic T Lymphocytes by Chemoradiotherapy in Patients Receiving Wilms’ Tumor 1-Targetted Dendritic Cell Vaccinations for Pancreatic Cancer
OMICS J Radiol,4(4):1000196 2015
Author:Shimodaira S, Kobayashi T, Hirabayashi K, Horiuchi K, Koya T, Mizuno Y, Yamaoka N, Yuzawa M, Ishikawa S, Higuchi Y, Sano K, Ito K, Koizumi T


Smoking Influences the Yield of Dendritic Cells for Cancer Immunotherapy
Pharmaceut Reg Affairs,4(1):1000133 2015
Author:Shimodaira S, Higuchi Y, Koya T, Kobayashi T, Yanagisawa R, Hirabayashi K, Ito K, Koizumi T, Maejima S, Udagawa N


Two Cases of Thymic Carcinoma Initially Presenting as Bone Metastasis: A Clinical Report and the Usefulness of CD5 Immunohistochemistry for Assessing Bone Lesions
Internal Medicine,54:1781-1785 2015
Author:Sasaki S, Fukushima T, Maruyama Y, Gomi D, Kobayashi T, Sekiguchi N, Sakamoto A, Koizumi T, Kitano K


Bronchoscopy-Guided Cooled Radiofrequency Ablation as a Novel Intervention Therapy for Peripheral Lung Cancer
Respiration,90(1):47-55 2015
Author:Koizumi T, Tsushima K, Tanabe T, Agatsuma T, Yokoyama T, Ito M, Kanda S, Kobayashi T, Yasuo M


Successful treatment of crizotinib-induced dysgeusia by switching to alectinib in ALK-positive non-small cell lung cancer
Lung Cancer,88:112-113 2015
Author:Koizumi T, Fukushima T, Tatai T, Kobayashi T, Sekiguchi N, Sakamoto A, Sasaki S


Clinical outcomes in patients with small cell lung cancer in a single institute: Comparative analysis of radiographic screening with symptom-prompted patients
Lung Cancer,88:48-51 2015
Author:Fukushima T, Tateishi K, Hanaoka M, Koizumi T


Tumor Size and Computed Tomography Attenuation of Pulmonary Pure Ground-Glass Nodules Are Useful for Predicting Pathological Invasiveness
PloS ONE,9(5):e97867 2014
Author:Eguchi T, Yoshizawa A, Kawakami S, Kumeda H, Umesaki T, Agatsuma H, Sakaizawa T, Tominaga Y, Toishi M, Hashizume M, Shiina T, Yoshida K, Asaka S, Matsushita M, Koizumi T


The potential efficacy of noninvasive ventilation with administration of a neutrophil elastase inhibitor for acute respiratory distress syndrome
J Crit Care,29(3):420-425 2014
Author:Tsushima K, Yokoyama T, Matsumura T, Koizumi T, Kubo K, Tatsumi K; Acute Lung Injury Group in Nagano


Successful Salvage Chemotherapy with Amrubicin for Invasive Thymoma Associated with Myasthenia Gravis
Jpn J Clin Oncol,44(11):1120-1122 2014
Author:Fukushima T, Gomi D, Kobayashi T, Sekiguchi N, Sakamoto A, Sasaki S, Koizumi T


Successful Concurrent Chemoradiotherapy with Cisplatin plus Vinorelbine for Locally Advanced Thymic Carcinoma
Case Rep Oncol,7:65-69 2014
Author:Fukushima T, Tateishi K, Hanaoka M, Koiwai K, Sasaki S, Koizumi T


Primary nonseminomatous germ cell tumor in the posterior mediastinum
Respirology Case Reports,20(4):276-283 2014
Author:Wada Y, Yokoyama T, Yamamoto H, Hanaoka M, Kawakami S, Koizumi T


Lung re-expansion following one-lung ventilation induces neutrophil cytoskeletal rearrangements in rats
Ann Thorac Cardiovasc Surg,20(4):276-283 2014
Author:Eguchi T, Hamanaka K, Kondo R, Saito G, Shiina T, Koizumi T, Yoshida K


Late-onset Rejection of a Unilateral Donor Lung with Vascular C4d Deposition in Bilateral Living-donor Lobar Lung Transplantation: An Autopsy Case Report
Intern Med,53:1645-1650 2014
Author:Yamamoto H, Yoshida K, Koizumi T, Tokoro Y, Fukushima T, Tateishi K, Ushiki A, Yokoyama T, Yasuo M, Urushihata k, Hanaoka M, Shingu K, shimojo H, Kanno H, Yoshizawa A, Kawakami S, Miyagawa-Hayashino A, Date H, Kubo K


Computed tomography attenuation predicts the growth of pure ground-glass nodules
Lung Cancer,84:242-247 2014
Author:Eguchi T, Kondo R, Kawakami S, Matsushita M, Yoshizawa A, Hara D, Matsuoka S, Takeda T, Miura K, Agatsuma H, Sakaizawa T, Tominaga Y, Saito G, Toishi M, Hamanaka K, Hashizume M, Shiina T, Amano J, Koizumi T, Yoshida K


Clinical characteristics and outcomes of patients with small cell lung cancer detected by CT screening
MEDICAL ONCOLOGY,30(3):623 2013(Sep.)
Author:Fukushima, T; Tateishi, K; Yamamoto, H; Hanaoka, M; Kubo, K; Koizumi, T


Surgical outcomes in patients with small cell lung cancer: comparative analysis of computed tomograpy-detected patients with others
WORLD JOURNAL OF SURGICAL ONCOLOGY,11(0):61 2013(Mar.)
Author:Koizumi, T; Fukushima, T; Hamanaka, K; Shiina, T; Yoshida, K; Kondo, R; Yamamoto, R; Nishizawa, N


間質性肺疾患に対するPMX-DHP療法の治療経験
エンドキシン血症救命治療研究会誌,17(1):57-63 2013
Author:横山俊樹、津島健司、立石一成、市山崇史、小坂充、堀内俊道、和田洋典、小泉知展、久保惠嗣


原発不明の印環細胞癌を含む粘液産生性腺癌の1例
信州医誌,61(5):283-287 2013
Author:鈴木敏郎、林田美江、山田博美、飯沼伸佳、高木哲、下條久志、小泉知展


関節リウマチに起因する間質性肺炎の経過中に発症した肺原発悪性リンパ腫の1例
信州医誌,61:13-18 2013
Author:出浦弦、吾妻俊彦、角田敏行、横山俊樹、久保恵嗣、小泉知展


Carboplatin併用化学療法時における悪心・嘔吐の発現に関する実態調査
癌と化学療法,40:355-359 2013
Author:百瀬華子、井出貴之、立石一成、小泉知展


The concept study of recombinant human soluble thrombomodulin in patients with acute respiratory distress syndrome
Inter Journal of Clinical Medicine,4:488-495 2013
Author:Tsushima K, Yokoyama T, Koizumi T, Kubo K, Tatsumi K


Clinical outcomes in elderly patients administered gefitinib as first-line treatment in epidermal growth factor receptor-mutated non-small-cell lung cancer: retrospective analysis in a Nagano Lung Cancer Research Group Study
Med Oncol,30:450-455 2013
Author:Tateishi K, Ichiyams T, Hirai K, Agatsuma T, Koyama S, Hachiya T, Morozumi N, Shiina T, Koizumi T


Efficacy of erlotinib plus concurrent whole-brain radiation therapy for patients with brain metastases from non-small cell lung cancer
Ann Palliat Med,2(3):111-113 2013
Author:Koizumi T, Sasaki S, Sakamoto A, Kobayashi T


Clinical experience of bronchoscopy-guided radiofrequency ablation for peripheral-type lung cancer
Case Rep Oncol Med,2013:515160 2013
Author:Koizumi T, Kobayashi T, Tanabe T, Tsushima K, Yasuo M


Comparative analysis of PET findings and clinical outcome in patients with primary mediastinal seminoma
Thoracic Cancer,4:241-248 2013
Author:Koizumi T, Katou A, Ikegawa K, Kosaka M, Tateishi K, Yokoyama T, Ushiki A, Kanda S, Tsushima K, Yamamoto H, Hanaoka M, Kubo K, Yshida K, Oguchi K


Sivelestat prevents cytoskeletal rearrangements in neutrophils resulting from lung ventilation during thoracic surgery
Inflammation,36(6):1479-1484 2013
Author:Eguchi T, Yoshida K, Kondo R, Hamanaka K, Shiina t, Komatsu Y, Yamamoto H, Kubo K, Hasegawa J, Koizumi T


Primary Malignant Sarcomatoid Mesothelioma in the Pericardium
INTERNAL MEDICINE,52(2):249-253 2013
Author:Tateishi, K; Ikeda, M; Yokoyama, T; Urushihata, K; Yamamoto, H; Hanaoka, M; Kubo, K; Sakai, Y; Nakayama, J; Koizumi, T


診断および治療経過を観察できた肺腺癌小腸転移の一例
肺癌,52:10-314 2012
Author:立石一成、小泉知展、漆畑一寿、山本洋、花岡正幸、久保惠嗣


縦隔原発骨外性骨肉腫の1例
日呼吸誌,1:197-200 2012
Author:鎌仲貴之、宮原隆成、堀田順一、鈴木敏郎、小泉知展、上原剛


Utility of 18F-fluorodeoxyglucose positron emission tomography for distinguishing between the histological types of early stage thymic epithelial tumours
Eur J Cardiothorac Surg,41:1059-1062 2012
Author:Eguchi T, Yoshida K, Hamanaka K, Shiina T, Koizumi T, Kawakami S, Oguchi K, Aamano J


Synchronous coexistence of gastrointestinal stromal tumor and primary lung adenocarcinoma
Intern Med,51(17):2407-2410 2012
Author:Wada Y, Koizumi T, Yokoyama T, Urushihata K, Yamamoto Y, Hanaoka M, Kubo K


Superior mesenteric artery syndrome after an initiation of cisplatin-containing chemotherapy
J Med Case Reports,6:14 2012
Author:Ushiki A, Koizumi T, Yamamoto H, Hanaoka M, Kubo K, Matsushita M


Successful retreatment with ADOC chemotherapy in relapsed thymic carcinoma -experiences in two cases-
World J Oncol,3:33-36 2012
Author:Nomura Y, Koizumi T, Kitaguchi Y, Horiuchi T, Kanda S, Yamamoto H, Hanaoka M, Kubo K


Prospective Study of Gefitinib Readministration After Chemotherapy in Patients with Advanced Non-Small-Cell Lung Cancer Who Previously Responded to Gefitinib
Clin Lung Cancer,13(6):458-463 2012
Author:Koizumi T, Agatsuma T, Ikegami K, Suzuki T, Kobayashi T, Kanda S, Yoshikawa S, Kubo K, Shiina T, Takasuna K, Matsuo K, Hayasaka M, Morikawa M, Ameshima S


Potential benefits of early continuous positive pressure ventilation in patients with rapidly progressive interstitial pneumonia
Respirology,17:315-321 2012
Author:Yokoyama T, Tsushima K, Yamamoto H, Koizumi T, Kubo K


Phase Ⅰ/Ⅱ study of S-1 combined with biweekly irinotecan chemotherapy in previously treated advanced non-small cell lung cancer
Cancer Chemother Parmacol,70:691-697 2012
Author:Goya H, Kuraishi H, Koyama S, Ichiyama T, Yoshiike F, Hirai K, Agatsuma T, Tateishi K, Kanda S, Yamamoto H, Kubo K, Koizumi T


Oropharyngeal metastasis of cardiogenic angiosarcoma
Intern Med,51:127-128 2012
Author:Kanda S, Koizumi T, Kobayashi N, Kubo K


Endobronchial Ultrasound-guided Transbronchial Needle Aspiration for the Diagnosis of Intrathoracic Lesions: Experience of a Single Academic Medical Center
Shinshu Medical Jouurnal,60(5):249-255 2012
Author:Yasuo M, Kobayashi T, Tokoro Y, Horiuchi T, Ito M, Kojima K, Ikegawa K, Ushiki A, Yamamoto H, Hanaoka M, Koizumi T, Yoshizawa A, Honda T, Kubo K


A phase Ⅱ trial of erlotinib in patients with EGFR wild-type advanced non-small-cell lungcancer
Cancer Chemother Pharmacol,69:1241-1246 2012
Author:Kobayashi T, Koizumi T, Agatsuma T, Yasuo M, Tsushima K, Kubo K, Eda S, Kuraishi H, Koyama S, Hachiya T, Ohura N


重症患者への基本的な抗生物質の使い方を教えて?
ナーシングケアQ&A40第7号全科に必要重症患者ケアQ&A第2版岡本和文編,40:236-238 2011
Author:伊東理子、小泉知展


肺癌
薬局増刊号病気と薬パーフェクトBOOK2011,増刊号:1626-1631 2011
Author:小林孝至、小泉知展


Phase ⅡTrial of biweekly paclitaxel and gemcitabine as second-line chemotherapyfor patients with non-small cell lung cancer previously treated with platinum-based chemotherapy.
Shinshu Medical J,59:411-418 2011
Author:Kobayashi T, Koizumi T, Yasuo M, Tsushima K, Yamamoto Y, Kubo K


Combination Chemotherapy with Doxorubicin, Vincristine, Cyclophosphamide, and Platinum Compounds for Advanced Thymic Carcinoma.
J Thoracic Oncol,12:2130-2134 2011
Author:Agatsuma T, Koizumi T, Kanda S, Ito M, Urushibata K, Yamamoto H, Hanaoka M, Kubo K


Gefitinib as First-line Treatment in Elderly Epidermal Growth Factor Receptor-mutated Patients with Advanced Lung Adenocarcinoma: Results of a Nagano Lung Cancer Research Group Study.
Clin Lung Cancer,12:387-392 2011
Author:Asami K, Koizumi T, Hirai K, Ameshima S, Tsukadaira A, Morozumi N, Morikawa A, Aragi S, Kawahara M


Different efficacy of CT screening for lung cancer according to histological type: Analysis of Japanese-smoker cases detected using a low-dose CT screen.
Lung Cancer,74:433-440 2011
Author:Kondo R, Yoshida K, Kawakami S, Shiina T, Kurai M, Takasuna K, Yamamoto H, Koizumi T, Honda T, Kubo K


Efficacy of CT screening for lung cancer in never-smokers: Analysis of Japanese cases detected using a low-dose CT screen
Lung Cancer,74:426-432 2011
Author:Kondo R, Yoshida K, Kawakami S, Shiina T, Kurai M, Takasuna K, Yamamoto H, Koizumi T, Honda T, Kubo K


An assessment by in situ hybridization method for the pathogens of severe respiratory infection.
Shinshu Med J,59:223-228 2011
Author:Matsubara M, Koizumi T, Ushiki A, Yokoyama T, Yashuo M, Yamamoto H, Kubo K, Yamazaki Y, Honda T


Elevated IgG4 levels in patients demonstrating sarcoidosis-like radiologic findings.
Medicine (Baltimore),90:194-200 2011
Author:Tsushima K, Yokoyama T, Kawa S, Hamano H, Tanabe T, Koizumi T, Honda T, Kawakami S, Kubo K


Pulmonary endothelial impairment during gefitinib therapy : a preliminary assessment with iodine-123-metaiodobenzylguanidine (123I-MIBG) scintigraphy.
The Open Lung Cancer Journal,4:1-3 2011
Author:Koizumi T, Urushihata K, Fujii T, Kubo K


IgG4-related airway involvement which developed in a patient receiving corticosteroid therapy for autoimmune pancreatitis.
Intern Med,50(24):3023-3026 2011
Author:Yamamoto H, Yasuo M, Nomura Y, Agatsuma T, Ushiki A, Yokoyama T, Urushihata K, Hanaoka M, Koizumi T, Iwaya M, Yoshikawa A, Kawakami S, Hamano H, Kawa S, Kubo K


Complete response to S-1 mono-therapy over 3 years in aneldery patient with advanced non-small cell lung cancer.
Shinshu Med J,59:321-325 2011
Author:Urushihata K, Agatsuma T, Yokooyama T, Ito M, Kubo K, Koizumi T, Shimojo H


Mantle cell lymphoma mainly involving thoracic lesions -Two case reports-.
Intern Med,50(14):1477-1481 2011
Author:Kosawa M, Koizumi T, Fukushima T, Wada Y, Agatsuma T, Yokoyama T, Kanda S, Kubo K, Shimojo H, Horie S, Asano N


Fatal interstitial pneumonia associated with oxaliplatin-based therapy in a patient with metastaic rectal cancer.
Clin J Gastroenterol,4:157-161 2011
Author:Ishizone S, Koide N, Akita N, Karasawa F, Kobayashi N, Koizumi T, Miyagawa S


IgG4-related pleural disease diagnosed by a re-evaluation of chronic bilateral pleuritis in a patient who experienced occasional acute left bacterial pleuritis.
Intern Med,50(8):893-897 2011
Author:Yamamoto H, Suzuki T, Yasuo M, Kobayashi O, Tsushima K, Ito M, Urushihata K, Yamazaki Y, Hanaoka M, Koizumi T, Uehara T, Kawakami S, Hamano H, KawaS, Kubo K,


Mediastinal growing teratoma syndrome successfully treated by multiple modality therapies.
Intern Med,50(6):607-610 2011
Author:Agatsuma T, Koizumi T, Kubo K, Saito G, Kondo R, Yoshida K, Ito K, Endo M, Simojo H


Successful S-1 monotherapy for chemorefractory thymic carcinoma.
Anticancer Res,31:299-301 2011
Author:Koizumi T, Agatsuma T,Komatsu Y, Kubo K,


―外来化学療法センターを訪ねて―信州大学医学部附属病院通院治療室
医薬の門,51:419-422 2011
Author:小泉知展、小川由則、井出貴之、所真由美


長野県内における呼吸器内科医の勤務状況に関する調査‐特に上小地域と他地域との比較‐
信州医誌,59:419-422 2011
Author:山本洋、小野百合子、安尾将法、漆畑一寿、花岡正幸、小泉知展、久保惠嗣


微小乳頭状構造を呈した肺線癌の1例
The Lung perpectives,19:446-449 2011
Author:牛木淳人、横山俊樹、神田慎太郎、安尾将法、漆畑一寿、山本洋、花岡正幸、小泉知展、久保惠嗣、遠藤真紀、福嶋万菜、中山淳


Iodine-123 metaiodobenzylguanidine scintigraphic assessment of pulmonary vascular status in patients with chronic obstructive pulmonary disease
RESPIROLOGY,15(8):1215-1219 2010(Nov.)
Author:Koizumi, Tomonobu; Urushihata, Kazuhisa; Hanaoka, Masayuki; Tsushima, Kenji; Fujimoto, Keisaku; Fujii, Tadashige; Kubo, Keishi


Comparison of acid-induced inflammatory responses in the rat lung during high frequency oscillatory and conventional mechanical ventilation
INFLAMMATION RESEARCH,59(11):931-937 2010(Nov.)
Author:Jian, Ming-Yuan; Koizumi, Tomonobu; Yokoyama, Toshiki; Tsushima, Kenji; Kubo, Keishi


Effects of a synthetic protease inhibitor (gabexate mesilate) and a neutrophil elastase inhibitor (sivelestat sodium) on acid-induced lung injury in rats
EUROPEAN JOURNAL OF PHARMACOLOGY,641(2-3):220-225 2010(Sep.)
Author:Yoshikawa, Sumiko; Tsushima, Kenji; Koizumi, Tomonobu; Kubo, Keishi


Exogenous surfactant instillation attenuates inflammatory response to acid-induced lung injury in rat
PULMONARY PHARMACOLOGY&THERAPEUTICS,23(1):43-47 2010(Feb.)
Author:Jian, Ming-Yuan; Koizumi, Tomonobu;Tsushima, Kenji; Yokoyama, Toshiki; Kubo, Keishi; Baba, Atsushi


Increased isoprostane levels in oleic acid-induced lung injury
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,388(2):297-300 2009(Oct.)
Author:Ono, Koichi; Koizumi, Tomonobu; Tsushima, Kenji; Yoshikawa, Sumiko; Yokoyama, Toshiki; Nakagawa, Rikimaru; Obata, Toru


Genetic Heterogeneity of EGFR Mutation in Pleomorphic Carcinoma of the Lung: Response to Gefitinib and Clinical Outcome
JAPANESE JOURNAL OF CLINICAL ONCOLOGY,39(4):267-270 2009(Apr.)
Author:Ushiki, Atsuhito; Koizumi, Tomonobu; Kobayashi, Nobumitsu; Kanda, Shintarou; Yasuo, Masanori; Yamamoto, Hiroshi; Kubo, Keishi; Aoyagi, Daiju; Nakayama, Jun


通院治療室利用患者における化学療法中断例の実態調査
信州医学雑誌,57(1):19-24 2009(Feb.)
Author:鈴木幸二,吾妻俊彦,山本洋,久保惠嗣,小泉知展
Keywords:outpatient chemotherapy,hematotoxicity,neutropenia,外来化学療法,血液毒性,白血球減少


Gradual Progression of Interstitial Pneumonia Induced by Bepridil
INTERNAL MEDICINE,48(23):2033-2035 2009
Author:Suzuki, Toshiro; Hanaoka, Masayuki; Yokoyama, Toshiki; Koizumi, Tomonobu; Kubo, Keishi


Colonic Sarcoidosis Presenting Multiple Submucosal Tumor-Like Lesions
INTERNAL MEDICINE,48(20):1813-1816 2009
Author:Ushiki, Atsuhito; Koizumi, Tomonobu; Kubo, Keishi; Suzawa, Kenichi; Arakura, Norikazu; Suzawa, Hirokazu


孤立性肺腫瘤陰影を呈しCA19-9が高値を示した 非結核性抗酸菌症の1例
信州医学雑誌,56(6):365-370 2008(Dec.)
Author:中川佐和子,吾妻俊彦,横山俊樹,牛木淳人,田名部毅,安尾将法,山本洋,花岡正幸,小泉知展,藤本圭作,久保惠嗣,椎名隆之,近藤竜一,吉田和夫,浅野功治,山﨑善隆
Keywords:solitary pulmonary mass shadow,CA19-9,nontuberculous,mycobacterial disease,孤立性肺腫瘤影,非結核性抗酸菌症


Pulmonary haemodynamic changes in patients with severe COPD
RESPIROLOGY,13(6):919-922 2008
Author:Hanaoka, M; Ideura, G; Ito, M; Urushihata, K; Koizumi, T; Fujimoto, K; Kubo, K


Reduced lung uptake of iodine-123 metaiodobenzylguanidine in high-altitude pulmonary oedema
RESPIROLOGY,13(6):897-902 2008
Author:Urushihata, K; Koizumi, T; Hanaoka, M; Fujimoto, K; Kubo, K; Kobayashi, T; Fujii,T


Endobronchial Argon Plasma Coagulation for the Palliation of Recurrent Tracheobronchial Adenoid Cystic Carcinoma
Journal of Bronchology,14(4):278-280 2007
Author:Yasuo,M;Tanabe,T;Tsushima,K;Komatsu,Y;Yamamoto,H;Hanaoka,M;Koizumi,T;Kubo,K;Wakamatsu,T;Hirose,Y;Yamazaki,Y


Successful endoscopic dilatation to alleviate airway suffocation in a case with esophageal cancer after stent implantation
INTERNAL MEDICINE,46(20):1745-1748 2007
Author:Yasuo, M; Furuya, S; Kanda, S; Komatsu, Y; Tanabe, T; Tsushima, K; Yamamoto, H; Koizumi, T; Kubo, K; Yokosawa, S; Yamazaki, Y; Kawakami, S


間質性肺炎の経過中に気胸を契機に発見された両側性多発肺扁平上皮癌の1例
肺癌,46(6):747-751 2006
Author:木村岳史,山崎誓一,小泉知展,久保惠嗣,兵庫谷章,吉田和夫


高地適応時の肺循環における一酸化窒素の関与
信州医学雑誌,53(3):131-138 2005(Jun.)
Author:小泉知展
Keywords:hypoxia, high-altitude pulmonaryedema, hypoxic pulmonary vasoconstriction, NOS inhibitor, eNOS gene polymorphisms, 低酸素, 高地肺水腫, 低酸素性肺血管収縮, NOS 阻害剤, eNOS 遺伝子多型


えのき栽培従事者に発症した培地が原因と考えられた過敏性肺臓炎の1例
信州医学雑誌,53(2):73-75 2005(Apr.)
Author:竹内崇博,笹林万里,津島健司,漆畑一寿,花岡正幸,小泉知展,藤本圭作,久保惠嗣
Keywords:hypersensitivity pneumonitis, culture medium of enoki mushrooms, 過敏性肺臓炎, えのき培地


孤立性結節陰影を呈した肺 Mycobacterium avium 感染症の1例
信州医学雑誌,52(4):257-260 2004(Aug.)
Author:角田敏行,小泉知展,久保惠嗣,小口寿夫,濱中一敏,西村秀紀,保坂典子
Keywords:solitary nodule, nontuberuculous mycobacteriosis, Mycobacterium tuberucurosis, 孤立結節, 非定型抗酸菌症, 結核


先行する肺血栓塞栓症後に肺癌が発見された1例
肺癌,42(4):267-271 2002
Author:三吉政道,小泉知展,小笠原仁,降旗兼行,山口伸二,久保惠嗣


Phase I trial of weekly docetaxel combined with cisplatin in patients with non-small-cell lungcancer
LUNG CANCER,34(1):125-131 2001
Author:Koizumi, T; Tsunoda, T; Fujimoto, K; Nomura, H; Hirai, K; Koyama, S; Okada, K; Kubo, K


Clearance of filtered fluid from the lung during exercise : role of hyperpnea
Am J Respir Crit Care Med,163:614-618 2001


Hypoxia-induced pulmonary blood redistribution in subjects with a history of high-altitude pulmonary edema
CIRCULATION,101(12):1418-1422 2000
Author:Hanaoka M


Serial scintigraphic assessment of iodine-123 metaiodobenzylguanidine lung uptake in a patient with high-altitude pulmonary edema
CHEST,116(4):1129-1131 1999
Author:Koizumi, T; Kubo, K; Hanaoka, M; Yamamoto, H; Yamaguchi, S; Fujii, T; Kobayashi, T


Pharmacokinetic evaluation of amphotericin B in lung tissue; lung lymph distribution after intravenous injection and airspace distribution after aerosolization and inhalation of Amphotericin B. Antimicrobial
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,42(7):1597-1600 1998
Author:Koizumi, T; Kubo, K; Kaneki, T; Hanaoka, M; Hayano, T; Miyahara, T; Okada, K; Fujimoto, K; Yamamoto, H; Kobayashi, T; Sekiguchi, M


Inhaled nitric oxide reduces lung fluid filtration after endotoxin in awake sheep
Am J Respir Crit Care Med,158:1416-1423 1998
Author:Bjertnaes LJ/ Koizumi T


Pulmonary infection with Mycobacterium avium-intracellulare leads to air trapping distal to the small airways
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE,158(3):979-984 1998
Author:Kubo K


Pharmacokinetic characteristics of the novel anticancer agent CPT-11 and its active metabolite in plasma and lung lymph fluid following intravenous administration to sheep
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH,48(11):1097-1100 1998
Author:Koizumi, T; Kubo, K; Hanaoka, M; Miyahara, T; Kaneki, T; Yamamoto, H; Ge, RL; Fujimoto, K; Kobayashi, T; Sekiguchi, M


Neutrophils pretreated with granulocyte colony-stimulating factor (G-CSF) are not related to the severity of endotoxin-induced lung injury
EXPERIMENTAL LUNG RESEARCH,23(5):393-404 1997
Author:Koizumi, T; Kubo, K; Koyama, S; Hanaoka, M; Hayano, T; Miyahara, T; Kobayashi, T; Sekiguchi,M


Inhaled nitric oxide and nitroglycerine reversal of pulmonary vasoconstriction inducedbyα-activation during exercise
Am J Physiol (Heart Circ. Physiol ),270(39):875-880 1996


学会発表
再発・難治多発性骨髄腫に対する当院でのthalidomide使用の検討
第11回日本臨床腫瘍学会 2013
Author:関口和、川上徹、妹尾紀子、仁科さやか、酒井均、伊藤俊朗、小泉知展、石田文宏


高齢者に発症した胸壁原発骨外性Ewing肉腫の一治療例
第11回日本臨床腫瘍学会 2013
Author:立石一成、福嶋敏郎、市山崇史、花岡正幸、久保惠嗣、和田洋典、佐野健司、関口和、佐々木茂、小泉知展


信州大学緩和ケアチームにおける非がん患者緩和ケアの現状と問題点
第18回日本緩和医療学会 2013
Author:坂本明之、関口和、佐々木茂、越由香里、加藤咲子、小泉知展


間質性肺疾患に対するPMX-DHP療法の治療経験
第17回エンドトキシン血症救命治療研究会 2013
Author:横山俊樹、津島健司、立石一成、市山崇史、小坂充、堀内俊道、和田洋典、小泉知展、久保惠嗣


縦隔原発胚細胞性セミノ―マにおける化学療法後FDG-PET所見の予後予測に対する有用性
第5回呼吸機能イメージング研究会学術集会 2013
Author:小泉知展


Novel computed tomography windows for predicting pathological invasion area in pulmonary subsolid tumors
15th World Conference on Lung Cancer 2013
Author:Eguchi T, Kawakami S, Yoshizawa A, Hara D, Matsuoka S, Takeda T, Miura K, Agatsuma H, Sakaizawa T, Tominaga Y, Toishi M, Hashizume M, Shiina T, Amano J, Matsushita M, Koizumi T, Kondo R, Takasuna K, Yoshida K


Tumor growth rate of ground-glass nodules after long-term follow-up: The usefulness of a combination of initial computed tomography attenuation and tumor size as a predictor for tumor growth
15th World Conference on Lung Cancer 2013
Author:Eguchi T, Kondo R, Kawakami S, Yoshizawa A, Hara D, Matsuoka S, Takeda T, Miura K, Agatsuma H, Sakaizawa T, Tominaga Y, Toishi M, Hashizume M, Shiina T, Amano J, Matsushita M, Koizumi T, Takasuna K, Yoshida K


Combination Chemotherapy with Doxorubicin, Vincristine, Cyclophosphamide, and Platinam Compounds for Advanced Thymic Carcinoma
5th APLCC and 3rd ITMIG 2012(Nov.)
Author:Koizumi T, Agatsuma T, Tateishi K, Fukushima T, Sonehara K, Ikeda M, Hama M, Horiuchi M, Ikegami K, Tokoro Y, Ushiki A, Yokoyama T, Kobayashi T, Yasuo M, Urushihata K, Hanaoka M, Kubo K


Clinical utility of serum CYFRA 21-1 in patient with thymic carcinoma
5th APLCC and 3rd ITMIG 2012(Nov.)
Author:Tateishi K, Koizumi T, Agatsuma T, Sonehara K, Ikeda M, Kinoda F, Ichiyama T, Hama M, Ikegami K, Tokoro Y, Kobayashi N, Horiuchi M, Yokoyama T, Ushiki A, Kobayashi T, Yasuo M, Urushihata K, Yamamoto H, Hanaoka M, Kubo K


Clinical Utility of CT-guided Bronchoscopy Radiofrequency Ablation as a Novel Intervention Therapy for Lung Cancer
5th APLCC and 3rd ITMIG 2012(Nov.)
Author:Koizumi T, Tanabe T, Tsushima K, Fukushima T, Hama M, Horiuchi M, Kobayashi N, Ikegami K, Tokoro Y, Ushiki A, Yokoyama T, Kobayashi T, Yasuo M, Urushihata K, Yamamoto H,Hanaoka M, Kubo K


Clinical analysis in patients with small-cell lung cancer (SCLC) detected by chest computed tomography (CT) mass-screenings in an institute
5th APLCC and 3rd ITMIG 2012(Nov.)
Author:Fukushima T, Tateishi K, Kubo K, Koizumi T


中等度催吐性がん化学療法を受ける患者に対する悪心・嘔吐の発現に関する実態調査
第10回日本臨床腫瘍学会学術集会 2012(Jul.)
Author:百瀬華子、井出貴之、立石一成、小泉知展


早期胸腺上皮性腫瘍のWHO組織分類におけるFDG-PETの有用性
第10回日本臨床腫瘍学会学術集会 2012(Jul.)
Author:江口隆、吉田和夫、三浦健太郎、吾妻寛之、境澤隆夫、齊藤学、橋都正洋、砥石政幸、椎名隆之、小泉知展


高齢者EGFR遺伝子変異陽性肺癌に対する初回gefitinib治療の後方視的検討―長野県内施設における解析―
第10回日本臨床腫瘍学会学術集会 2012(Jul.)
Author:立石一成、福嶋敏郎、神田慎太郎、市山崇史、平井一也、吾妻俊彦、塚平晃弘、両角延聡、早坂宗治、森川明男、小松佳道、蜂谷勤、椎名隆之、久保惠嗣、小泉知展

教育活動実績

授業等
2002 , 臨床腫瘍学