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小林聡  コバヤシ アキラ

教員組織学術研究院(医学系)電話番号
教育組織医学部 医学科 外科学第一FAX番号
職名准教授メールアドレス
住所ホームページURL

更新日:2019/07/08

プロフィール

研究分野
肝胆膵外科学
現在の研究課題
肝虚血再潅流障害の機序

胆道癌に対する外科治療の安全性と根治性の向上
キーワード:胆道癌
所属学会
所属学会
日本外科学会
日本消化器外科学会
日本肝臓学会
日本肝胆膵外科学会
日本消化器病学会
日本内視鏡外科学会
日本移植学会
日本胆道学会
日本臨床外科学会
学歴
出身学校・専攻等(大学院を除く)
1990 , 東北大学 , 医学部
研究職歴等
研究職歴
2000- , 信州大学医学部付属病院第1外科 助手
1990-2000 , 信州大学医学部第1外科 研修医

研究活動業績

研究業績(著書・
発表論文等)
論文
A Case of Pancreatic Carcinoma with Bilateral Hilar 18F-FDG and 67Ga Hyperaccumulation
信州医学雑誌,66(2):151-155 2018(Apr. 10)
Author:Kawakami, Satoshi; Fujinaga, Yasunari; Yanagisawa, Shin; Kadoya, Masumi; Kobayashi, Akira; Oguchi, Kazuhiro


Survival pathway of cholangiocarcinoma via AKT/mTOR signaling to escape RAF/MEK/ERK pathway inhibition by sorafenib
ONCOLOGY REPORTS,39(2):843-850 2018(Feb.)
Author:Yokoi, Kenta; Kobayashi, Akira; Motoyama, Hiroaki; Kitazawa, Masato; Shimizu, Akira; Notake, Tsuyoshi; Yokoyama, Takahide; Matsumura, Tomio; Takeoka, Michiko; Miyagawa, Shin-Ichi;


術前診断に造影MRIが有用であった胆囊粘液癌の1例
日本消化器外科学会雑誌,51(6):423-430 2018
Author:増尾 仁志;宮川 眞一;小林 聡;横山 隆秀;清水 明;本山 博章;野竹 剛;北川 敬之;上原 剛;山田 哲
Abstract:

症例は70歳の女性で,検診で胆囊腫瘍を指摘され当科に紹介となった.腹部USで胆囊体部肝側に粘膜下腫瘍様の形態を示すechogenicな隆起性病変を認めた.腹部MRIでは同部に15 mm大,T2強調像で腫瘍内部が腎臓よりも強い高信号を呈する腫瘤を認めた.ダイナミックMRIでは辺縁および内部がmesh likeに漸増性濃染を示した.MRI所見から粘液基質を豊富に含む充実性腫瘍が示唆され,胆囊粘液癌と診断した.胆囊床切除を伴う胆囊摘出術,肝外胆管切除と領域リンパ節郭清を行った.病理組織学所見上,癌細胞は間質に粘液を伴って浸潤増殖しており,胆囊粘液癌と診断した.胆囊粘液癌の診断には,充実性腫瘍であることに加え,腫瘍内に粘液基質の存在を示すことが重要である.造影MRIは腫瘍の形態や造影効果のみならず,腫瘍内部に存在する間質の質的評価も同時に行えるため,胆囊粘液癌の診断に有用であると思われた.


Keywords:胆囊粘液癌;MRI;術前画像診断


Fascin1 suppresses RIG-I-like receptor signaling and interferon-beta production by associating with I kappa B kinase epsilon (IKK epsilon) in colon cancer
JOURNAL OF BIOLOGICAL CHEMISTRY,293(17):6326-6336 2018
Author:Matsumura, Tomio; Hida, Shigeaki; Kitazawa, Masato; Fujii, Chifumi; Kobayashi, Akira; Takeoka, Michiko; Taniguchi, Shun-ichiro; Miyagawa, Shin-ichi;


Nomogram predicting long-term survival after the diagnosis of intrahepatic recurrence of hepatocellular carcinoma following an initial liver resection
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY,22(6):1103-1103 2017(Dec.)
Author:Kobayashi, Akira; Notake, Tsuyoshi;


Survival Benefits of Surgical Resection in Patients with Recurrent Biliary Tract Carcinoma
WORLD JOURNAL OF SURGERY,41(11):2817-2829 2017(Nov.)
Author:Motoyama, Hiroaki; Kobayashi, Akira; Yokoyama, Takahide; Shimizu, Akira; Kitagawa, Noriyuki; Notake, Tsuyoshi; Fukushima, Kentaro; Masuo, Hitoshi; Yoshizawa, Takahiro; Miyagawa, Shin-ichi;


Nomogram predicting long-term survival after the diagnosis of intrahepatic recurrence of hepatocellular carcinoma following an initial liver resection
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY,22(4):715-725 2017(Aug.)
Author:Notake, Tsuyoshi; Kobayashi, Akira; Shinkawa, Hiroji; Kawahara, Takuya; Shimizu, Akira; Yokoyama, Takahide; Hasegawa, Kiyoshi; Kokudo, Norihiro; Matsuyama, Yutaka; Makuuchi, Masatoshi; Miyagawa, Shin-ichi;


Adjuvant Chemotherapy with Gemcitabine for Resected Biliary Tract Cancer: A Single-Arm Phase 2 Study
信州医学雑誌,65(2):99-111 2017(Apr. 10)
Author:Kitagawa, Noriyuki; Motoyama, Hiroaki; Kobayashi, Akira; Yokoyama, Takahide; Shimizu, Akira; Notake, Tsuyoshi; Fukushima, Kentaro; Masuo, Hitoshi; Yoshizawa, Takahiro; Tsukahara, Teruomi; Miyagawa, Shin-ichi


Clinicopathological characteristics of non-B non-C hepatocellular carcinoma without past hepatitis B virus infection
HEPATOLOGY RESEARCH,47(5):405-418 2017(Apr.)
Author:Kimura, Takefumi; Kobayashi, Akira; Tanaka, Naoki; Sano, Kenji; Komatsu, Michiharu; Fujimori, Naoyuki; Yamazaki, Tomoo; Shibata, Soichiro; Ichikawa, Yuki; Joshita, Satoru; Umemura, Takeji; Matsumoto, Akihiro; Horiuchi, Akira; Mori, Hiromitsu; Wada, Shuichi; Kiyosawa, Kendo; Miyagawa, Shin-ichi; Tanaka, Eiji;


ASC Induces Apoptosis via Activation of Caspase-9 by Enhancing Gap Junction - Mediated Intercellular Communication
PLOS ONE,12(1):- 2017
Author:Kitazawa, Masato; Hida, Shigeaki; Fujii, Chifumi; Taniguchi, Shun'ichiro; Ito, Kensuke; Matsumura, Tomio; Okada, Nagisa; Sakaizawa, Takashi; Kobayashi, Akira; Takeoka, Michiko; Miyagawa, Shin-ichi;


Correlation between the serum levels of type IV collagen 7s domain and the risk of intractable ascites following liver resection for hepatocellular carcinoma: A propensity score-matched analysis
SURGERY,160(5):1244-1255 2016(Nov.)
Author:Shimizu, Akira; Kobayashi, Akira; Yokoyama, Takahide; Motoyama, Hiroaki; Sakai, Hiroshi; Kitagawa, Noriyuki; Notake, Tsuyoshi; Shirota, Tomoki; Fukushima, Kentaro; Miyagawa, Shin-ichi;


Neuroendocrine tumor of the common bile duct
SURGERY,160(2):525-526 2016(Aug.)
Author:Hosoda, Kiyotaka; Kobayashi, Akira; Shimizu, Akira; Kitagawa, Noriyuki; Ito, Tetsuya; Yamada, Akira; Miyagawa, Shin-ichi;


Contrast-enhancement ratio on multiphase enhanced computed tomography predicts recurrence of pancreatic neuroendocrine tumor after curative resection
PANCREATOLOGY,16(3):397-402 2016
Author:Arai, Takuma; Kobayashi, Akira; Fujinaga, Yasunari; Yokoyama, Takahide; Shimizu, Akira; Motoyama, Hiroaki; Kitagawa, Noriyuki; Notake, Tsuyoshi; Shirota, Tomoki; Fukushima, Kentaro; Masuo, Hitoshi; Kadoya, Masumi; Miyagawa, Shin-ichi;


Application of Gadoxetate Disodium-Enhanced MR Imaging in a Rat Model of Acute Partial Liver Congestion
HEPATOLOGY,62:639A-640A 2015(Oct.)
Author:Shimizu, Akira; Kobayashi, Akira; Yokoyama, Takahide; Motoyama, Hiroaki; Sakai, Hiroshi; Kitagawa, Noriyuki; Notake, Tsuyoshi; Shirota, Tomoki; Fukushima, Kentaro; Miyagawa, Shinichi;


Application of Gadoxetate Disodium-Enhanced MR Imaging in a Rat Model of Acute Partial Liver Congestion
HEPATOLOGY,62:639A-640A 2015(Oct.)
Author:Shimizu, Akira; Kobayashi, Akira; Yokoyama, Takahide; Motoyama, Hiroaki; Sakai, Hiroshi; Kitagawa, Noriyuki; Notake, Tsuyoshi; Shirota, Tomoki; Fukushima, Kentaro; Miyagawa, Shinichi;


Features of acute liver congestion on gadoxetate disodium-enhanced MRI in a rat model: Role of organic anion-transporting polypeptide 1A1
JOURNAL OF MAGNETIC RESONANCE IMAGING,42(3):828-836 2015(Sep.)
Author:Shimizu, Akira; Kobayashi, Akira; Motoyama, Hiroaki; Sakai, Hiroshi; Yamada, Akira; Yoshizawa, Akihiko; Momose, Masanobu; Kadoya, Masumi; Miyagawa, Shin-ichi;


Features of acute liver congestion on gadoxetate disodium-enhanced MRI in a rat model: Role of organic anion-transporting polypeptide 1A1
JOURNAL OF MAGNETIC RESONANCE IMAGING,42(3):828-836 2015(Sep.)
Author:Shimizu, Akira; Kobayashi, Akira; Motoyama, Hiroaki; Sakai, Hiroshi; Yamada, Akira; Yoshizawa, Akihiko; Momose, Masanobu; Kadoya, Masumi; Miyagawa, Shin-ichi;


Biliary tract variations of the left liver with special reference to the left medial sectional bile duct in 500 patients
AMERICAN JOURNAL OF SURGERY,210(2):351-356 2015(Aug.)
Author:Furusawa, Norihiko; Kobayashi, Akira; Yokoyama, Takahide; Shimizu, Akira; Motoyama, Hiroaki; Kanai, Keita; Arakura, Norikazu; Yamada, Akira; Kitou, Yoshihiro; Miyagawa, Shin-ichi;


Effect of Application of Subcutaneous Suction Drainage with Subcuticular Sutures for Wound Closure on the Incidence of Incisional Surgical Site Infection following Elective General Abdominal Surgery : A Randomized Controlled Trial
信州医学雑誌,63(2):91-101 2015(Apr. 10)
Author:SHIMIZU, Akira; KOBAYASHI, Akira; KOIDE, Naohiko; SUZUKI, Akira; TAKEUCHI, Daisuke; YOKOYAMA, Takahide; MOTOYAMA, Hiroaki; FURUSAWA, Norihiko; TSUKAHARA, Teruomi; MIYAGAWA, Shin-ichi


Impact of advanced age on the short- and long-term outcomes in patients undergoing hepatectomy for hepatocellular carcinoma: a single-center analysis over a 20-year period
AMERICAN JOURNAL OF SURGERY,209(4):733-741 2015(Apr.)
Author:Motoyama, Hiroaki; Kobayashi, Akira; Yokoyama, Takahide; Shimizu, Akira; Sakai, Hiroshi; Furusawa, Norihiko; Notake, Tsuyoshi; Kitagawa, Noriyuki; Arai, Takuma; Yokoi, Kenta; Okubo, Yohei; Miyagawa, Shin-ichi;


Signal intensity of the pancreas on magnetic resonance imaging: Prediction of postoperative pancreatic fistula after a distal pancreatectomy using a triple-row stapler
PANCREATOLOGY,15(4):380-386 2015
Author:Arai, Takuma; Kobayashi, Akira; Yokoyama, Takahide; Ohya, Ayumi; Fujinaga, Yasunari; Shimizu, Akira; Motoyama, Hiroaki; Furusawa, Norihiko; Sakai, Hiroshi; Uehara, Takeshi; Kadoya, Masumi; Miyagawa, Shin-ichi;


Surgical Treatment of 144 Cases of Hilar Cholangiocarcinoma Without Liver-Related Mortality
WORLD JOURNAL OF SURGERY,38(5):1164-1176 2014(May)
Author:Furusawa, Norihiko; Kobayashi, Akira; Yokoyama, Takahide; Shimizu, Akira; Motoyama, Hiroaki; Miyagawa, Sin-ichi


Optimal Initial Dose of Orally Administered Once-daily Extended-release Tacrolimus Following Intravenous Tacrolimus Therapy After Liver Transplantation
TRANSPLANTATION PROCEEDINGS,46(3):794-796 2014(Apr.)
Author:Mita, A.; Ikegami, T.; Masuda, Y.; Katsuyama, Y.; Ohno, Y.; Urata, K.; Nakazawa, Y.; Kobayashi, A.; Miyagawa, S.


Successful Active Immunization Using a Hepatitis B Virus Vaccination Protocol for a Recipient With Hepatitis B Core Antibody-Positive Liver Graft
TRANSPLANTATION PROCEEDINGS,46(3):721-725 2014(Apr.)
Author:Ohno, Y.; Mita, A.; Ikegami, T.; Masuda, Y.; Urata, K.; Nakazawa, Y.; Kobayashi, A.; Miyagawa, S.


Comparison of histopathological features of pancreatic carcinoma and type 1 autoimmune pancreatitis
PATHOLOGY INTERNATIONAL,64(2):51-57 2014(Feb.)
Author:Uehara, Takeshi; Hamano, Hideaki; Kawa,Shigeyuki; Kobayashi, Yukihiro; Yoshizawa, Akihiko; Oki, Keiko; Nakata, Rie; Kobayashi, Akira; Sano, Kenji; Ota, Hiroyoshi


Hepatectomy preserving drainage veins of the posterior section for liver malignancy invading the right hepatic vein: an alternative to right hepatectomy
AMERICAN JOURNAL OF SURGERY,204(5):717-723 2012(Nov.)
Author:Shimizu, Akira; Kobayashi, Akira; Yokoyama, Takahide; Nakata, Takenari; Motoyama, Hiroaki; Kubota, Koji; Furusawa, Norihiko; Kitahara, Hiroe; Kitagawa, Noriyuki; Fukushima, Kentaro; Shirota, Tomoki; Miyagawa, Shinichi


Temporary Auxiliary Partial Orthotopic LiverTransplantation Using a Small Graft for Familial Amyloid Polyneuropathy
AMERICAN JOURNAL OF TRANSPLANTATION,12(8):2211-2219 2012(Aug.)
Author:Ohno, Y.; Mita, A.; Ikegami, T.; Masuda, Y.; Urata, K.; Nakazawa, Y.; Kobayashi, A.; Terada, M.; Ikeda, S.; Miyagawa, S.


Impaired degradation followed by enhanced recycling of epidermal growth factor receptor caused by hypo-phosphorylation of tyrosine 1045 in RBE cells
BMC CANCER,12 2012(May 16)
Author:Gui, Anping; Kobayashi, Akira; Motoyama, Hiroaki; Kitazawa, Masato; Takeoka, Michiko; Miyagawa, Shinichi


A New procedure for temporary auxiliary partial liver transplantation using living donor graft for patients with familial amyloid polyneuropathy
LIVER TRANSPLANTATION,18(5):608-611 2012(May)
Author:Ohno, Yasunari; Kobayashi, Akira; Ikegami, Toshihiko; Masuda, Yuichi; Mita, Atsuyoshi; Urata, Koichi; Nakazawa, Yuichi; Terada, Masaru; Ikeda, Shu-ichi; Miyagawa, Shinichi


Left hepatectomy
J Hepatobiliary Pancreat Sci,19(1):38-43 2012
Author:Kobayashi A, Miyagawa S


Role of bone marrow cells in the development of pancreatic fibrosis in a rat model of pancreatitis induced by a choline-deficient/ethionine-supplemented diet
Biochem Biophys Res Commun,420(4):743-9 2012
Author:Akita S, Kubota K, Kobayashi A, Misawa R, Shimizu A, Nakata T, Yokoyama T, Takahashi M, Miyagawa S


Impaired degradation followed by enhanced recycling of epidermal growth factor receptor
BMC Cancer,16(12):179 2012
Author:Gui A, Kobayashi A, Motoyama H, Kitazawa M, Takeoka M, Miyagawa S


Hepatectomy preserving drainage veins of the posterior section for liver malignancy invading the right hepatic vein: an alternative to right hepatectomy
Am J Surg,204(5):717-72 2012
Author:Shimizu A, Kobayashi A, Yokoyama T, Nakata T, Motoyama H, Kubota K, Furusawa N, Kitahara H, Kitagawa N, Fukushima K, Shirota T, Miyagawa S


A New Procedure for Temporary Auxiliary Partial Liver Transplantation Using Living Donor Graft for Patients With Familial Amyloid Polyneuropathy
Liver Transpl,18(5):608-611 2012
Author:Yasunari Ohno,Akira Kobayashi,Toshihiko Ikegami,Yuichi Masuda,Atsuyoshi Mita,Koichi Urata,Yuichi Nakazawa,Masaru Terada,Shu-ichi Ikeda,Shinishi Miyagawa.


A case report of follicular lymphoma arising from the extrahepatic bile duct: interesting contrast-enhanced ultrasonographic findings.
Clin J gastroenterol.,4:129-134 2011
Author:Uchikawa Y, Nakata T, Akita S, Motoyama H, Suzuki F, Shimizu A, Yokoyama T, Kobayashi A, Fukushima M, Miwa S, Miyagawa S.


Controversies Surrounding the Management of Hilar Cholangiocarcinoma and the Surgical Outcomes.
Cancer Reports,1(2):1-10 2011
Author:Akira Kobayashi, Shinichi Miyagawa


Transabdominal preperitoneal repair for obturator hernia.
World J Surg.,35:2323-7 2011
Author:Yokoyama T, Kobayashi A, Kikuchi T, Hayashi K,Miyagawa S.


Induction of LYVE-1/stabilin-2-positive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling
Peptides.,32:1855-65. 2011
Author:Arai T, Sakurai T, Kamiyoshi A,Ichikawa-Shindo Y, Iinuma N, Iesato Y, Koyama T, Yoshizawa T, Uetake R, Yamauchi A, Yang L, Kawate H, Ogawa S, Kobayashi A, Miyagawa S, Shindo T.


Advances in therapeutics for liver metastasis from colorectal cancer
World J Gastrointest Oncol.,15:380-389 2010
Author:Kobayashi A, Miyagawa S


Disease recurrence patterns after R0 resection of hilar cholangiocarcinoma.
Br J Surg,97:56-64 2010
Author:Kobayashi A, Miwa S, Nakata T, Miyagawa S.


Clinical and pathological features of primary carcinoma of the cystic duct.
J Hepatobiliary Pancreat Surg,16:75-82 2009
Author:25. Nakata T, Kobayashi A, Miwa S, Soeda J, Uehara T, Miyagawa S. Clinical and pathological features of primary carcinoma of the cystic duct.


Prognosis of adult patients transplanted with liver grafts<35% of their standard liver volume
Liver Transpl,15:1622-1630 2009
Author:Ikegami T, Masuda Y, Ohno Y, Mita A, Kobayashi A, Urata K, Nakazawa Y, Miwa S, Hashikura Y, Miyagawa S


Increased expression of thioredoxin-1, vascular endothelial growth factor, and redox factor-1 is associated with poor prognosis in patients with liver metastasis from colorectal cancer.
Hum Pathol,39:201-208 2008
Author:Noike T, Miwa S, Soeda J, Kobayashi A, Miyagawa S


Identification of genes associated with multiple nodules in hepatocellular carcinoma using cDNA microarray: multicentric occurrence or intrahepatic metastasis?
Hepatogastroenterology,55:865-872 2008
Author:Nakata T, Seki N, Miwa S, Kobayashi A, Soeda J, Nimura Y, Kawasaki S, Miyagawa S.


Prognostic impact of anatomical resection on early and late intrahepatic recurrence in patients with hepatocellular carcinoma.
J Hepatobiliary Pancreat Surg,15:515-521 2008
Author:Kobayashi A, Miyagawa S, Miwa S, Nakata T.


Impact of tumor spread to the cystic duct on the prognosis of patients with gallbladder carcinoma.
World J Surg,31:162-153 2007
Author:Nakata T, Kobayashi A, Miwa S, Soeda J, Miyagawa S


Is major hepatectomy with pancreatoduodenectomy justified for advanced biliary malignancy?
J Hepatobiliary Pancreat Surg,14:136-141 2007
Author:Miwa S, Kobayashi A, Akahane Y, Nakata T, Mihara M, Kusama K, Ogawa S, Soeda J, Miyagawa S


Predictive factors for intrahepatic cholangiocarcinoma recurrence in the liver following surgery
JOURNAL OF GASTROENTEROLOGY,41(9):893-900 2006
Author:Miwa, S; Miyagawa, S; Kobayashi, A; Akahane, Y; Nakata, T; Mihara, M; Kusama, K; Soeda, J; Ogawa, S


Results of 404 hepatic resections including 80 repeat hepatectomies for hepatocellular carcinoma
HEPATO-GASTROENTEROLOGY,53(71):736-741 2006
Author:Kobayashi, A; Kawasaki, S; Miyagawa, S; Miwa, S; Noike, T; Takagi, S; Iijima, S; Miyagawa, Y


Successfultreatment for combined pancreatoduodenal injury by a second-stage pancreatojejunostomy following pancreatoduodenectomy
Hepatogastroenterology,51:1674-1675 2004
Author:Sekino Y, Kobayashi A, Takagi S, Miwa S, Miyagawa S


Dendritic cells, T-cell infiltration, and Grp94 expression in cholangiocellular carcinoma
HUMAN PATHOLOGY,35(7):881-886 2004
Author:Takagi S, Miyagawa S, Ichikawa E, Soeda J, Miwa S, Miyagawa Y, Iijima S, Noike T, Kobayashi A, Kawasaki S


Outcome of surgical therapy for hilar bile duct carcinoma
JOURNAL OF HEPATOLOGY,38:188-188 2003
Author:Miyagawa, S; Miwa, S; Kobayashi, A; Noike, T; Kawasaki, S


Results of surgical resection for patients with hilar bile duct cancer - Application of extended hepatectomy after biliary drainage and hemihepatic portal vein embolization
ANNALS OF SURGERY,238(1):84-92 2003
Author:Kawasaki, S; Imamura, H; Kobayashi, A; Noike, T; Miwa, S; Miyagawa, S


Expression of HIF-2 alpha and platelet-derived endothelial cell growth factor in hepatocellular carcinoma.
HEPATOLOGY,36(4):699A-699A 2002
Author:Iijima, S; Miyagawa, S; Noike, T; Miwa, S; Soeda, J; Takagi, S; Ichikawa, E; Kobayashi, A; Kawasaki, S


GRP94 and dendritic cells in patients with cholangiocellular carcinoma.
HEPATOLOGY,36(4):396A-396A 2002
Author:Takagi, S; Miyagawa, SI; Ichikawa, E; Soeda, J; Miyagawa, Y; Iijima, S; Noike, T; Kobayashi, A; Miwa, S; Kawasaki, S


Inhibition of apoptosis by caspase inhibitor prevents upregulation of cytokine expression after ischemia/reperfusion (I/R) injury of the rat liver
HEPATOLOGY,36(4):299A-299A 2002
Author:Kobayashi, A; Imamura, H; Soeda, J; Ogawa, SI; Kawasaki, S


Morphometric analysis of liver macrophages in patientswith colorectal liver metastasis
CLINICAL&EXPERIMENTAL METASTASIS,19(2):119-125 2002
Author:Miyagawa S, Miwa S, Soeda J, Kobayashi A, Kawasaki S


Identification of hepatic venous territories in liver resection by using color Doppler ultrasonography - Report of two cases
JOURNAL OF ULTRASOUND IN MEDICINE,20(5):545-548 2001
Author:Kitamura, H; Miyagawa, Y; Yokoyama, T; Kobayashi, A; Miwa, S; Miyagawa, S; Kawasaki, S


Value of lipiodol computed tomography and digital subtraction angiography in the era of helical biphasic computed tomography as preoperative assessment of hepatocellularcarcinoma
ANNALS OF SURGERY,234(1):56-62 2001
Author:Nakayama, A; Imamura, H; Matsuyama, Y; Kitamura, H; Miwa, S; Kobayashi, A; Miyagawa, S; Kawasaki, S


Kupffer cells and tumor microvessel density in patients with colorectal liver metastasis.
HEPATOLOGY,34(4):679A-679A 2001
Author:Miyagawa, S; Miwa, S; Soeda, J; Kobayashi, A; Kawasaki, S


Inhibition of apoptosis by caspase inhibitor prevents inflammation and hepatocellular damage after ischemia/reperfusion (I/R) injury of the rat liver.
HEPATOLOGY,34(4):304A-304A 2001
Author:Kobayashi, A; Imamura, H; Soeda, J; Matsuyama, Y; Kawasaki, S


Mac-1 (CD11b/CD18) and intercellular adhesion molecule-1 in ischemia-reperfusion injury of rat liver
Am J PhysiolGastrointest Liver Physiol,281(2):577-85 2001
Author:Kobayashi A/ Imamura H/ Isobe M/ Matsuyama Y/ Soeda J/ Matsunaga K/ Kawasaki S


Role of MAC-1 (CD11B/CD18) and intercellular adhesion molecule 1 (ICAM-1) in sinusoidal endothelial cell damage and hepatocyte apoptosis resulting from ischemia/reperfusion (I/R) injury of the rat liver
HEPATOLOGY,32(4):335A-335A 2000
Author:Kobayashi, A; Imamura, H; Isobe, M; Matsuyama, Y; Matsunaga, K; Kawasaki, S


Risk factors contributing to early and late phases of intrahepatic recurrence of hepatocellular carcinoma (HCC) after hepatectomy.
HEPATOLOGY,32(4):237A-237A 2000
Author:Imamura, H; Kawasaki, S; Takayama, T; Miyagawa, S; Kobayashi, A; Makuuchi, M


Relationship between doubling time of liver metastases from colorectal carcinoma and residual primary cancer
DIGESTIVE SURGERY,15(1):21-24 1998
Author:Nomura, K; Miyagawa, S; Harada, H; Kitamura, H; Seki, H; Shimada, R; Kobayashi, A; Noike, T; Kawasaki, S


Staged hepatectomy after emergency transcatheter arterial embolization for ruptured hepatocellular carcinoma
SURGERY,124(3):526-535 1998
Author:Shimada, R; Imamura, H; Makuuchi, M; Soeda, J; Kobayashi, A; Noike, T; Miyagawa, S; Kawasaki, S


Time course of MAC-1 and ICAM-1 expression following normothermic ischemia-reperfusion (I/R) injury inrat liver.
HEPATOLOGY,28(4):185A-185A 1998
Author:Kobayashi, A; Imamura, H; Isobe, M; Kawasaki, S


Plasma concentration of endothelin-1 does not reflect renal vasoconstriction as estimated by duplex ultrasonography in cirrhosis
DIGESTIVE DISEASES AND SCIENCES,42(3):542-545 1997
Author:Kitamura, H; Shimda, R; Kobayashi, A; Nomura, K; Noike, T; Harada, H; Miyagawa, S; Kawasaki, S


Extended right posterior segmentectomy for metastatic liver tumors
SURGERY,121(6):698-703 1997
Author:Kobayashi A/ Imamura H/ Miyagawa S/ Shimada R/ Makuuchi M/ Kawasaki S


BENIGN STRUCTURE OF THE INTRAHEPATIC BILE-DUCT WITH ARTERIAL INVOLVEMENT
HEPATO-GASTROENTEROLOGY,41(1):79-81 1994
Author:HASHIKURA, Y; MAKUUCHI, M; KAWASAKI, S; MIWA, S; KOBAYASHI, A; IMAI, Y; OTA, H

研究費
科学研究費補助金(研究代表者)
2017 - , 特異的細胞表面マーカーによる、切除肝からの内在性幹細胞の単離 , 基盤研究(C)
2013 - , 肝幹細胞を用いたインスリン産生細胞分化誘導による膵切除後内分泌機能不全治療戦略 , 基盤研究C
2010 - , 膵臓内・外分泌前駆細胞相互作用を応用した細胞リプログラミングとその解析 , 基盤研究C
2002 - , 脂肪肝ラットにおける肝虚血再灌流障害のメカニズムに関する検討と臨床応用への試み , 若手研究
2007 - 2008 , 肝細胞癌特異的結合ペプチド付加抗癌剤の開発 , 基盤研究(C)

科学研究費補助金(研究分担者)
2014 - , 新規ペプチドを用いた胆管癌治療法の開発 , 基盤研究B

教育活動実績

授業等
2013 , 臨床医学入門、肝切除
2011 , 通年 , ユニット講義、胆道腫瘍
2007 , 通年 , ユニット講義、膵癌
2006 , 通年 , ユニット講義、門脈圧亢進症
2002 , 外科学