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水木 将  ミズキ マサル

教員組織電話番号
教育組織医学部 医学科 衛生学公衆衛生学FAX番号
職名助教(特定雇用)メールアドレス
住所〒390-8621 長野県松本市旭3-1-1ホームページURL

プロフィール

研究分野
社会医学
学歴
出身学校・専攻等(大学院を除く)
2013 , 信州大学 , 医学部 , 医学科

取得学位
学士(医学) , 信州大学

研究活動業績

研究業績(著書・
発表論文等)
書籍等出版物
文化財の虫菌害防除と安全の知識 2016年
公益財団法人 文化財虫菌害研究所 2015(Dec.)
Author:野見山哲生,塚原照臣,津田洋子,新井浩朗,水木将


論文
Effects of Lactoferrin on Prevention of Acute Gastrointestinal Symptoms in Winter: A Randomized, Double-Blinded, Placebo-Controlled Trial for Staff of Kindergartens and Nursery Schools in Japan
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH,17(24) 2020(Dec.)
Author:Mizuki Masaru, Tsukahara Teruomi, Oda Hirotsugu, Tanaka Miyuki, Yamauchi Koji, Abe Fumiaki, Nomiyama Tetsuo
Keywords:lactoferrin; diarrhea; kindergarten; winter; subjective acute gastrointestinal symptoms;


Effects of Lactoferrin on Sleep Conditions in Children Aged 12-32 Months: A Preliminary, Randomized, Double-Blind, Placebo-Controlled Trial
NATURE AND SCIENCE OF SLEEP,12:671-677 2020
Author:Miyakawa Momoko, Kubo Shutaro, Oda Hirotsugu, Motoki Noriko, Mizuki Masaru, Tsukahara Teruomi, Tanaka Miyuki, Yamauchi Koji, Abe Fumiaki, Nomiyama Tetsuo
Keywords:lactoferrin; sleep; growing-up formula; children;


Effects of Lactoferrin-Fortified Formula on Acute Gastrointestinal Symptoms in Children Aged 12-32 Months: A Randomized, Double-Blind, Placebo-Controlled Trial
FRONTIERS IN PEDIATRICS,8 2020
Author:Motoki Noriko, Mizuki Masaru, Tsukahara Teruomi, Miyakawa Momoko, Kubo Shutaro, Oda Hirotsugu, Tanaka Miyuki, Yamauchi Koji, Abe Fumiaki, Nomiyama Tetsuo
Keywords:lactoferrin; infectious disease; diarrhea; growing-up formula; children;


呼吸用保護具の適切な装着を阻害する要因の検討と装着指導の効果に関する研究
信州公衆衛生雑誌,13(2):81-85 2019(Mar.)
Author:水木将、伊東黄、梅原舞、小林若菜、佐藤渉、辻野亮、藤田楓、堀谷勇介、米良健輝、森下開、長谷川航平、塚原照臣、野見山哲生


Effects of Lactoferrin on Subjective Skin Conditions in Winter: A Preliminary, Randomized, Double-Blinded, Placebo-Controlled Trial
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY,12:875-880 2019
Author:Oda Hirotsugu, Miyakawa Momoko, Mizuki Masaru, Misawa Yuka, Tsukahara Teruomi, Tanaka Miyuki, Yamauchi Koji, Abe Fumiaki, Nomiyama Tetsuo
Keywords:lactoferrin; winter; skin; moisture; texture;


病院職員における喫煙状況と喫煙意識に関する調査
信州公衆衛生雑誌,10(2):61-66 2016(Mar.)
Author:水木将、新井浩朗、塚原照臣、中島めぐみ、松澤幸範、古川賢一、野見山哲生


労働者における禁煙の挑戦及び達成に寄与する因子の解明のための研究
信州公衆衛生雑誌,10(2):67-74 2016(Mar.)
Author:新井浩朗、水木将、上條ともこ、藤澤美和子、松澤幸範、塚原照臣、野見山哲生


講演・口頭発表等
呼吸用保護具の密着性に影響を与える 動作要因と装着指導の効果 の検討に関する調査研究
第92回日本産業衛生学会 2019(May 23)
Presenter:水木将、塚原照臣、野見山哲生


保護マスクの漏れ率に装着指導、発声等が与える影響に関する調査研究
信州公衆衛生雑誌 13 1 58-59 2018(Aug.)
Presenter:水木 将, 森下 開, 伊東 黄, 梅原 舞, 小林 若菜, 佐藤 渉, 辻野 亮, 藤田 楓, 堀谷 勇介, 米良 健輝, 塚原 照臣, 野見山 哲生


1-ブロモプロパン曝露職場における環境改善
産業衛生学雑誌 60 2 48 2018(Mar.)
Presenter:野見山 哲生, 塚原 照臣, 水木 将, 竹内 靖人, 市原 学


1-ブロモプロパン曝露職場の職場環境改善による曝露低減の試み
産業衛生学雑誌 60 2 51 2018(Mar.)
Presenter:野見山 哲生, 塚原 照臣, 水木 将, 竹内 靖人, 市原 学


ラクトフェリン摂取による冬季の感染症予防効果-幼稚園、保育園を対象とした二重盲検ランダム化比較試験から-
日本ラクトフェリン学会第7回学術集会、 2016年度臨床ラクトフェリン研究会合同大会 2016(Oct. 30)
Presenter:水木将、三澤由佳、塚原照臣、織田浩嗣、若林裕之、山内恒治、阿部文明、野見山哲生


トリクロロエチレン取扱い作業者における防毒マスクの効果の検討
2016(May 26)
Presenter:水木将、津田洋子、塚原照臣、野見山哲生


高年齢労働者に対する就業支援に関する研究
産業衛生学雑誌 58 臨増 228 2016(May)
Presenter:野見山 哲生, 上條 知子, 水木 将, 塚原 照臣, 矼 暎雄


トリクロロエチレン取扱い作業者における防毒マスクの効果の検討
産業衛生学雑誌 58 臨増 288 2016(May)
Presenter:水木 将, 津田 洋子, 塚原 照臣, 野見山 哲生


MISC
Effects of lactoferrin on sleep conditions in children aged 12-32 months: a preliminary, randomized, double-blind, placebo-controlled trial.
Nat Sci Sleep,12:671 2020
Author:Miyakawa M, Kubo S, Oda H, Motoki N, Mizuki M, Tsukahara T, Tanaka M, Yamauchi K, Abe F, Nomiyama T
Abstract:Purpose: To investigate preliminarily the effect of lactoferrin (LF)-fortified formula on sleep conditions in children. Study design: A preliminary, randomized, double-blind, placebo-controlled trial. Methods: Healthy children between the ages of 12 and 32 months who attended nursery schools in Japan were divided into two groups and assigned a placebo or LF (48 mg/day)-fortified formula. Children's sleep conditions were investigated before and after the 13-week intervention using the Japanese Sleep Questionnaire for Preschoolers (JSQ-P). Results: Altogether, 109 participants were randomized. Eight participants were eliminated due to lost to follow-up, withdrawal of consent, and ineligibility, with 101 participants (placebo, n = 48; LF, n = 53) included in the full analysis set (FAS) and used for analysis. Wake-up time, bedtime, and nighttime sleep were comparable between the two groups before and after intervention. The change in total JSQ-P T scores tended to improve in the LF group (placebo vs LF: 0.5 ± 6.5 vs -1.9 ± 6.1, p = 0.074), in particular, morning symptoms significantly improved (grumpy in the morning, hard to wake-up, and hard to get out of bed) (placebo vs LF: 0.8 ± 6.2 vs -1.9 ± 6.2, p = 0.028). A better trend was also observed in the LF group regarding restless legs syndrome (RLS)-motor (rubs feet at night and touches feet at night) (placebo vs LF: 2.3 ± 10.7 vs -0.6 ± 13.5, p = 0.083) and insufficient sleep (stays up more than one hour later the day before a holiday and wakes up more than one hour later on a holiday) (placebo vs LF: 0.1 ± 9.8 vs -1.7 ± 8.8, p = 0.095). No adverse drug reactions were found. Conclusion: LF intake may improve sleep condition, especially morning symptoms in children above one year of age.


Effects of lactoferrin-fortified formula on acute respiratory and gastrointestinal illnesses in children aged 12-32 months: A randomized, double-blind, placebo-controlled trial.
Front. Pediatr.,8:233 2020
Author:Motoki N, Mizuki M, Tsukahara T, Miyakawa M, Kubo S, Oda H, Tanaka M, Yamauchi K, Abe F, Nomiyama T
Abstract:Objective: We investigated the effects of lactoferrin (LF)-fortified formula on acute gastrointestinal and respiratory symptoms in children. Design: Randomized, double-blind, placebo-controlled trial. Setting and subjects: Children aged 12-32 months in Japan. Intervention: Intake of placebo or LF (48 mg/day)-fortified formula for 13 weeks. Primary endpoint: Prevalence of acute gastrointestinal and respiratory symptom. Results: One hundred nine participants were randomized. Eight participants were lost to follow-up, withdrew consent, or were deemed inappropriate for the trial, with 101 participants receiving complete analyses (placebo group, n = 48; LF group, n = 53). Outcomes: The prevalence of acute gastrointestinal symptoms was significantly less in the LF group (22/53 [41.5%]) than in the placebo group (30/48 [62.5%], p = 0.046). The total number of days having acute respiratory symptoms was significantly lower in the LF group (9.0) than in the placebo group (15.0, p = 0.030). Harms: The rate of adverse events was similar between the groups. No adverse drug reactions were found. Conclusions: LF intake decreased the prevalence of acute gastrointestinal symptoms in children aged 12-32 months.


Effects of lactoferrin on prevention of acute gastrointestinal symptoms in winter: A randomized, double-blinded, placebo-controlled trial for staff of kindergartens and nursery schools in Japan.
Int J Environ Res Public Health,17(24):9582 2020
Author:Mizuki M, Tsukahara T, Oda H, Tanaka M, Yamauchi K, Abe F, Nomiyama T
Abstract:This study investigated the preventive effects of lactoferrin (LF) on subjective acute gastrointestinal symptoms during the winter in a randomized, double-blinded, placebo-controlled parallel-group comparative trial. The eligible subjects were healthy adults working at kindergartens and nursery schools. We randomized the subjects to the Placebo group (0 mg/day), the Low LF group (200 mg/day), and the High LF group (600 mg/day) for 12 weeks. The prevalence of acute gastrointestinal symptoms was significantly lower in the High LF (13/112 vs. 26/116; p = 0.030) and the Low LF (13/107 vs. 26/116; p = 0.040) groups than in the Placebo group. The adjusted odds ratio for the prevalence of acute gastrointestinal symptoms was 2.78 (95% CI: 1.19–6.47) in the Placebo group compared with the High LF group. LF is useful to prevent acute gastrointestinal symptoms among childcare workers, who mainly consist of women.