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神吉昭子  カミヨシ アキコ

教員組織学術研究院(医学系)電話番号
教育組織大学院医学系研究科 疾患予防医科学系専攻 個体機能制御学部門 循環病態学FAX番号
職名助教メールアドレス
住所〒390-8621 長野県松本市旭3-1-1ホームページURL

プロフィール

研究分野
実験動物学
現在の研究課題
CGRPによる免疫反応制御と肝保護作用機序の解明
キーワード:CGRP , 肝炎
AM-RAMP2系による肝臓脂質代謝制御とメタボリックシンドロームにおける意義
キーワード:AM , メタボリックシンドローム
所属学会
所属学会
日本循環器学会
日本実験動物学会
日本分子生物学会
日本内分泌学会
学歴
出身大学院
2000 , 東邦大学 , 理学研究科 , 生物分子科学専攻

出身学校・専攻等(大学院を除く)
1998 , 東邦大学 , 理学部 , 生物分子科学科

取得学位
博士(医学) , 信州大学
研究職歴等
研究職歴
2006- , 信州大学大学院医学系研究科 助教
2005-2006 , 長野県テクノ財団 研究員
2005-2005 , 信州大学大学院医学系研究科 奨励研究員
2000-2005 , 信州大学ヒト環境科学研究支援センター 研究支援推進員

研究活動業績

研究業績(著書・
発表論文等)
著書
アドレノメデュリン-RAMP2システムによる、白色脂肪、褐色脂肪の脂質、エネルギー代謝制御
血管 , 37(4):135-139 2014
Author:神吉昭子、桜井敬之、河手久香、新藤優佳、植竹龍一、山内啓弘、五十嵐恭子、鳥山佑一、田中愛、劉甜、羨鮮、今井章、翟留玉、大和慎治、新藤隆行


再生医療の展望:再生医療と遺伝子工学-ES細胞の利用を例に-
信州医学雑誌 , 51:361-362 2003
Author:田川陽一、神吉昭子


論文
The endothelial adrenomedullin-RAMP2 system regulates vascular integrity and suppresses tumor metastasis
Cardiovasc Res,111(4):398-409 2016
Author:Tanaka M, Koyama T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Liu T, Xian X, Imai A, Zhai L, Hirabayashi K, Owa S, Yamauchi A, Igarashi K, Taniguchi S, Shindo T


A non-inheritable maternal Cas9-based multiple-gene editing system in mice
Sci Rep,6(20011) 2016
Author:Sakurai T, Kamiyoshi A, Kawate H, Mori C, Watanabe S, Tanaka M, Uetake R, Sato M, Shindo T


Adrenomedullin-RAMP2 System in Vascular Endothelial Cells
J Atheroscler Thromb,22(7):647-53 2015
Author:Koyama T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Shindo T


Pathophysiological function of endogenous calcitonin gene-related peptide in ocular vascular diseases
Am J Pathol,185(6):1783-94 2015
Author:Toriyama Y, Iesato Y, Imai A, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Igarashi K, Tanaka M, Liu T, Xian X, Zhai L, Owa S, Murata T, Shindo T


Functional differentiation of RAMP2 and RAMP3 in their regulation of the vascular system
J Mol Cell Cardiol,77:73-85 2014
Author:Yamauchi A, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Igarashi K, Toriyama Y, Tanaka M, Liu T, Xian X, Imai A, Zhai L, Owa S, Arai T, Shindo T


Pathophysiological roles of adrenomedullin-RAMP2 system in acute and chronic cerebral ischemia
Peptides,62:21-31 2014
Author:Igarashi K, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Toriyama Y, Tanaka M, Liu T, Xian X, Imai A, Zhai L. Owa S, Koyama T, Uetake R, Ihara M, Shindo T


A single blastocyst assay optimized for detecting CRISPR/Cas9 system-induced indel mutations in mice
BMC Biotechnol,14:69 2014
Author:Sakurai T, Watanabe S, Kamiyoshi A, Sato M, Shindo T


Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection
PLoS One,9(2):e87667 2014
Author:Uetake R, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Yoshizawa T, Koyama T, Yang L, Toriyama Y, Yamauchi A, Igarashi K, Tanaka M, Kuwabara T, Mori K, Yanagita M, Mukoyama M, Shindo T


Regulation of adrenomedullin and its family peptide by RAMP system--lessons from genetically engineered mice
Curr Protein Pept Sci,14(5):347-357 2013
Author:Shindo T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Shimoyama N, Iinuma N, Arai T, Miyagawa S


Adrenomedullin-RAMP2 system is crucially involved in retinal angiogenesis
Am J Pathol,182(6):2380-2390 2013
Author:Iesato Y, Toriyama Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yoshizawa T, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Igarashi K, Murata T, Shindo T


Endogenous CGRP protects against neointimal hyperplasia following wire-induced vascular injury
J Mol Cell Cardiol,59:55-66 2013
Author:Yang L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yoshizawa T, Koyama T, Iesato Y, Uetake R, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Shindo T


Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system
Hypertension,61(2):341-351 2013
Author:Yoshizawa T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Nakada T, Kashihara T, Yamada M, Kawakami H, Nakanishi H, Taguchi R, Nakanishi T, Akazawa H, Shindo T


Vascular endothelial adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis
Circulation,127(7):842-853 2013
Author:Koyama T, Ochoa-Callejero L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Iinuma N, Arai T, Yoshizawa T, Iesato Y, Lei Y, Uetake R, Okimura A, Yamauchi A, Tanaka M, Igarashi K, Toriyama Y, Kawate H, Adams RH, Kawakami H, Mochizuki N, Martinez A, Shindo T


Adrenomedullin-RAMP2 system in cardiovascular development and homeostasis
Current Hypertension Reviews,7:217-227 2011
Author:Shindo T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y


Induction of LYVE-1/stabilin-2-positive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling
Peptides,32(9):1855-1865 2011
Author:Arai T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Iinuma N, Iesato Y, Koyama T, Yoshizawa T, Uetake R, Yamauchi A, Yang L, Kawate H, Ogawa S, Kobayashi A, Miyagawa S, Shindo T


Adrenomedullin in sinusoidal endothelial cells play protective roles against cold injury of liver
Peptides,31(5):865-871 2010
Author:Iinuma N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Arai T, Yoshizawa T, Koyama T, Uetake R, Kawate H, Muto S, Tagawa Y, Miyagawa S, Shindo T


Endogenous a-calcitonin gene-related peptide mitigates liver fibrosis in chronic hepatitis induced byrepeated administration of concanavalin A
Liver Int,29(5):642-649 2009
Author:Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Iinuma N, Kawate H, Yoshizawa T, Koyama T, Muto S, Shindo T


Rapid zygosity determination in mice by SYBR Green real-time genomic PCR of a crude DNA solution
Transgenic Res,17(1):149-155 2008
Author:Sakurai T, Kamiyoshi A, Watanabe S, Sato M, Shindo T


GPCRmodulator protein RAMP2 is essential for angiogenesis and vascular integrity
J Clin Invest,118(1):29-39 2008
Author:Ichikawa-Shindo Y, Sakurai T, Kamiyoshi A, Kawate H, Iinuma N, Yoshizawa T, Koyama T, Fukuchi J, Iimuro S, Moriyama N, Kawakami H, Murata T, Kangawa K, Nagai R, Shindo T


Endogenous alphaCGRP protects against concanavalin A-induced hepatitis in mice
Biochem Biophys Res Commun,343(1):152-158 2006
Author:Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Fukuchi J, Kawate H, Muto S, Tagawa Y, Shindo T


Characterization of cytochrome P450 expression in murine embryonic stem cell-derived hepatic tissue system
DRUG METABOLISM AND DISPOSITION,34(4):696-701 2006
Author:Tsutsui M, Ogawa S, Inada Y, Tomioka E, Kamiyoshi A, Tanaka S, Kishida T, Nishiyama M, Murakami M, Kuroda J, Hashikura Y, Miyagawa S, Satoh F, Shibata N, Tagawa Y


Azelnidipine, a long-acting dihydropyridine calcium channel blocker, suppresses the development of cardiac hypertrophy and fibrosis in adrenomedullin knock out mice.
CIRCULATION,114(18):13-13 2006
Author:Shindo T, Niu P, Kamiyoshi A, Sakurai T, Ichikawa Y, Iinuma N, Kawate H


Tea catechin, epigallocatechin-3-gallate, inhibits rubratoxin B-induced apoptosis of hepatocytes through MAPK p38 pathway
Mycotoxins,55(1):17-22 2005
Author:Kagaya N, Kamiyoshi A, Tagawa Y, Nagashima H, Kawase M, Yagi K


Interaction of rubratoxin B with serum albumin
Mycotoxins,55(1):23-26 2005
Author:Kagaya N, Kamiyoshi A, Tagawa Y, Nagashima H, Kawase M, Yagi K


Suppression of cell death in primary rat hepatocytes by a1-acid glycoprotein
J Biosci Bioeng,99(1):81-83 2005
Author:Kagaya N, Kamiyoshi A, Tagawa Y, Akamatsu S, Isoda K, Kawase M, Yagi K


Effect of zinc on hepatoprotectivity of a1-acid glycoprotein
Biomedical Research on Trace Elements,16(4):299-301 2005
Author:Kawase M, Kagaya N, Kamiyoshi A, Tagawa Y, Yagi K


Crucial roles of mesodermal cell lineages in a murine embryonic stem cell-derived in vitro liver organogenesis system
STEM CELLS,23(7):903-913 2005
Author:Ogawa S, Tagawa Y, Kamiyoshi A, Suzuki A, Nakayama J, Hashikura Y, Miyagawa S


Liver organogenesis from murine embryonic stem cells - A substitute system for an animal experiment
HEPATOLOGY,42(4):746A-747A 2005
Author:Ogawa S, Tagawa Y, Kamiyoshi A, Motoyama H, Tsutsui M, Sato F, Nishiyama M, Nakayama J, Hashikura Y, Miyagawa S


Liver protection by bis(maltolato)zinc(II) complex
Exp Anim,53(1):1-9 2004
Author:Kawase M, Kagaya N, Akamatsu S, Kamiyoshi A, Muto S, Tagawa Y, Yagi K


Novel function of rare catechin, epigallocatechin-3-(3"-O-methyl)gallate, against cold injury in primary rat hepatocytes
J Biosci Bioeng,96(6):559-563 2003
Author:Kagaya N, Hara Y, Saijo R, Kamiyoshi A, Tagawa Y, Kawase M, Yagi K


Survival and function of mouse embryonic stem cell-derived cardiomyocytes in ectopic transplants
CARDIOVASCULAR RESEARCH,58(2):435-443 2003
Author:Johkura K, Cui L, Suzuki A, Teng RF, Kamiyoshi A, Okamura S, Kubota S, Zhao X, Asanuma K, Okouchi Y, Ogiwara N, Tagawa Y, Sasaki K