論文 Receptor Activity Modifying Protein RAMP Sub-Isoforms and Their Functional Differentiation, Which Regulates Functional Diversity of Adrenomedullin Biology,11(5):788 2022(May) Author:Shindo T, Tanaka M, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Sakurai T.
Adrenomedullin ameliorates pulmonary fibrosis by regulating TGF-β-Smads signaling and myofibroblast differentiation Endocrinology,162(8):bqab090 2021(Aug.) Author:Wei Y, Tanaka M, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Cui N, Kakihara S, Zhao Y, Aruga K, Sanjo H, Shindo T.
Adrenomedullin-receptor activity-modifying protein 2 system ameliorates subretinal fibrosis by suppressing epithelial-mesenchymal transition in age-related macular degeneration Am J Pathol,191(4):652-668 2021(Apr.) Author:Tanaka M, Kakihara S, Hirabayashi K, Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Cui N, Wei Y, Zhao Y, Aruga K, Yamauchi A, Murata T, Shindo T.
Adrenomedullin-RAMP2 and -RAMP3 systems regulate cardiac homeostasis during cardiovascular stress Endocrinology,162(3):bqab001 2021(Mar.) Author:Cui N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Tanaka M, Wei Y, Kakihara S, Zhao Y, Aruga K, Kawagishi H, Nakada T, Yamada M, Shindo T.
Deficiency of the adrenomedullin-RAMP3 system suppresses metastasis through the modification of cancer-associated fibroblasts Oncogene,39(9):1914-1930 2020(Feb.) Author:Dai K, Tanaka M, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Cui N, Wei Y, Tanaka M, Kakihara S, Matsui S, Shindo T.
Production of genetically engineered mice with higher efficiency, lower mosaicism, and multiplexing capability using maternally expressed Cas9 Sci Rep,10(1):1091 2020(Jan.) Author:Sakurai T, Kamiyoshi A, Kawate H, Watanabe S, Sato M, Shindo T.
Endogenous Calcitonin Gene-Related Peptide Deficiency Exacerbates Postoperative Lymphedema by Suppressing Lymphatic Capillary Formation and M2 Macrophage Accumulation Am J Pathol,189(12):2487-2502 2019(Dec.) Author:Matsui S, Tanaka M, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Dai K, Cui N, Wei Y, Tanaka M, Kakihara S, Nakamura K, Yamauchi A, Ishida K, Tanaka S, Kawamata M, Shindo T.
Bindel-PCR: a novel and convenient method for identifying CRISPR/Cas9-induced biallelic mutants through modified PCR using Thermus aquaticus DNA polymerase Sci Rep,9(1):9923 2019(Jul. 09) Author:Sakurai T, Kamiyoshi A, Takei N, Watanabe S, Sato M, Shindo T.
Development of a Novel Model of Central Retinal Vascular Occlusion and the Therapeutic Potential of the Adrenomedullin-Receptor Activity-Modifying Protein 2 System AMERICAN JOURNAL OF PATHOLOGY,189(2):449-466 2019(Feb.) Author:Hirabayashi, Kazutaka; Tanaka, Masaaki; Imai, Akira; Toriyama, Yuichi; Iesato, Yasuhiro; Sakurai, Takayuki; Kamiyoshi, Akiko; Ichikawa-Shindo, Yuka; Kawate, Hisaka; Tanaka, Megumu; Dai, Kun; Cui, Nanqi; Wei, Yangxuan; Nakamura, Keisei; Iida, Shiho; Matsui, Shuhei; Yamauchi, Akihiro; Murata, Toshinori; Shindo, Takayuki;
Regulation of cardiovascular development and homeostasis by the adrenomedullin-RAMP system PEPTIDES,111:55-61 2019(Jan.) Author:Shindo, Takayuki; Tanaka, Megumu; Kamiyoshi, Akiko; Ichikawa-Shindo, Yuka; Kawate, Hisaka; Yamauchi, Akihiro; Sakurai, Takayuki;
Endogenous calcitonin gene-related peptide suppresses ischemic brain injuries and progression of cognitive decline. J Hypertens,36(4):876-891 2018(Apr.) Author:Zhai L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Xian X, Hirabayashi K, Dai K, Cui N, Tanimura K, Liu T, Wei Y, Tanaka M, Tomiyama H, Yamauchi A, Igarashi K, Shindo T.
Placental extract ameliorates non-alcoholic steatohepatitis (NASH) by exerting protective effects on endothelial cells. Heliyon,3(9):e00416 2017(Sep. 27) Author:Yamauchi A, Kamiyoshi A, Koyama T, Iinuma N, Yamaguchi S, Miyazaki H, Hirano E, Kaku T, Shindo T.
Endogenous Calcitonin Gene-Related Peptide Regulates Lipid Metabolism and Energy Homeostasis in Male Mice. Endocrinology,158(5):1194-1206 2017(May) Author:Liu T, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Yang L, Tanaka M, Xian X, Imai A, Zhai L, Hirabayashi K, Dai K, Tanimura K, Liu T, Cui N, Igarashi K, Yamauchi A, Shindo T.
Vasoprotective Activities of the Adrenomedullin-RAMP2 System in Endothelial Cells. Endocrinology,158(5):1359-1372 2017(May) Author:Xian X, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Tanaka M, Koyama T, Kawate H, Yang L, Liu T, Imai A, Zhai L, Hirabayashi K, Dai K, Tanimura K, Liu T, Cui N, Igarashi K, Yamauchi A, Shindo T.
Adrenomedullin Suppresses Vascular Endothelial Growth Factor-Induced Vascular Hyperpermeability and Inflammation in Retinopathy. Am J Pathol,187(5):999-1015 2017(May) Author:Imai A, Toriyama Y, Iesato Y, Hirabayashi K, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Liu T, Xian X, Zhai L, Dai K, Tanimura K, Liu T, Cui N, Yamauchi A, Murata T, Shindo T.
The endothelial adrenomedullin-RAMP2 system regulates vascular integrity and suppresses tumor metastasis Cardiovasc Res,111(4):398-409 2016 Author:Tanaka M, Koyama T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Liu T, Xian X, Imai A, Zhai L, Hirabayashi K, Owa S, Yamauchi A, Igarashi K, Taniguchi S, Shindo T
A non-inheritable maternal Cas9-based multiple-gene editing system in mice Sci Rep,6(20011) 2016 Author:Sakurai T, Kamiyoshi A, Kawate H, Mori C, Watanabe S, Tanaka M, Uetake R, Sato M, Shindo T
Adrenomedullin-RAMP2 System in Vascular Endothelial Cells J Atheroscler Thromb,22(7):647-53 2015 Author:Koyama T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Shindo T
Pathophysiological function of endogenous calcitonin gene-related peptide in ocular vascular diseases Am J Pathol,185(6):1783-94 2015 Author:Toriyama Y, Iesato Y, Imai A, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Igarashi K, Tanaka M, Liu T, Xian X, Zhai L, Owa S, Murata T, Shindo T
Functional differentiation of RAMP2 and RAMP3 in their regulation of the vascular system J Mol Cell Cardiol,77:73-85 2014 Author:Yamauchi A, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Igarashi K, Toriyama Y, Tanaka M, Liu T, Xian X, Imai A, Zhai L, Owa S, Arai T, Shindo T
Pathophysiological roles of adrenomedullin-RAMP2 system in acute and chronic cerebral ischemia Peptides,62:21-31 2014 Author:Igarashi K, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Toriyama Y, Tanaka M, Liu T, Xian X, Imai A, Zhai L. Owa S, Koyama T, Uetake R, Ihara M, Shindo T
A single blastocyst assay optimized for detecting CRISPR/Cas9 system-induced indel mutations in mice BMC Biotechnol,14:69 2014 Author:Sakurai T, Watanabe S, Kamiyoshi A, Sato M, Shindo T
Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection PLoS One,9(2):e87667 2014 Author:Uetake R, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Yoshizawa T, Koyama T, Yang L, Toriyama Y, Yamauchi A, Igarashi K, Tanaka M, Kuwabara T, Mori K, Yanagita M, Mukoyama M, Shindo T
Regulation of adrenomedullin and its family peptide by RAMP system--lessons from genetically engineered mice Curr Protein Pept Sci,14(5):347-357 2013 Author:Shindo T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Shimoyama N, Iinuma N, Arai T, Miyagawa S
Adrenomedullin-RAMP2 system is crucially involved in retinal angiogenesis Am J Pathol,182(6):2380-2390 2013 Author:Iesato Y, Toriyama Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yoshizawa T, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Igarashi K, Murata T, Shindo T
Endogenous CGRP protects against neointimal hyperplasia following wire-induced vascular injury J Mol Cell Cardiol,59:55-66 2013 Author:Yang L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yoshizawa T, Koyama T, Iesato Y, Uetake R, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Shindo T
Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system Hypertension,61(2):341-351 2013 Author:Yoshizawa T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Nakada T, Kashihara T, Yamada M, Kawakami H, Nakanishi H, Taguchi R, Nakanishi T, Akazawa H, Shindo T
Vascular endothelial adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis Circulation,127(7):842-853 2013 Author:Koyama T, Ochoa-Callejero L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Iinuma N, Arai T, Yoshizawa T, Iesato Y, Lei Y, Uetake R, Okimura A, Yamauchi A, Tanaka M, Igarashi K, Toriyama Y, Kawate H, Adams RH, Kawakami H, Mochizuki N, Martinez A, Shindo T
Adrenomedullin-RAMP2 system in cardiovascular development and homeostasis Current Hypertension Reviews,7:217-227 2011 Author:Shindo T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y
Induction of LYVE-1/stabilin-2-positive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling Peptides,32(9):1855-1865 2011 Author:Arai T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Iinuma N, Iesato Y, Koyama T, Yoshizawa T, Uetake R, Yamauchi A, Yang L, Kawate H, Ogawa S, Kobayashi A, Miyagawa S, Shindo T
Adrenomedullin in sinusoidal endothelial cells play protective roles against cold injury of liver Peptides,31(5):865-871 2010 Author:Iinuma N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Arai T, Yoshizawa T, Koyama T, Uetake R, Kawate H, Muto S, Tagawa Y, Miyagawa S, Shindo T
Endogenous a-calcitonin gene-related peptide mitigates liver fibrosis in chronic hepatitis induced byrepeated administration of concanavalin A Liver Int,29(5):642-649 2009 Author:Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Iinuma N, Kawate H, Yoshizawa T, Koyama T, Muto S, Shindo T
Rapid zygosity determination in mice by SYBR Green real-time genomic PCR of a crude DNA solution Transgenic Res,17(1):149-155 2008 Author:Sakurai T, Kamiyoshi A, Watanabe S, Sato M, Shindo T
GPCRmodulator protein RAMP2 is essential for angiogenesis and vascular integrity J Clin Invest,118(1):29-39 2008 Author:Ichikawa-Shindo Y, Sakurai T, Kamiyoshi A, Kawate H, Iinuma N, Yoshizawa T, Koyama T, Fukuchi J, Iimuro S, Moriyama N, Kawakami H, Murata T, Kangawa K, Nagai R, Shindo T
Endogenous alphaCGRP protects against concanavalin A-induced hepatitis in mice Biochem Biophys Res Commun,343(1):152-158 2006 Author:Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Fukuchi J, Kawate H, Muto S, Tagawa Y, Shindo T
Characterization of cytochrome P450 expression in murine embryonic stem cell-derived hepatic tissue system DRUG METABOLISM AND DISPOSITION,34(4):696-701 2006 Author:Tsutsui M, Ogawa S, Inada Y, Tomioka E, Kamiyoshi A, Tanaka S, Kishida T, Nishiyama M, Murakami M, Kuroda J, Hashikura Y, Miyagawa S, Satoh F, Shibata N, Tagawa Y
Azelnidipine, a long-acting dihydropyridine calcium channel blocker, suppresses the development of cardiac hypertrophy and fibrosis in adrenomedullin knock out mice. CIRCULATION,114(18):13-13 2006 Author:Shindo T, Niu P, Kamiyoshi A, Sakurai T, Ichikawa Y, Iinuma N, Kawate H
Tea catechin, epigallocatechin-3-gallate, inhibits rubratoxin B-induced apoptosis of hepatocytes through MAPK p38 pathway Mycotoxins,55(1):17-22 2005 Author:Kagaya N, Kamiyoshi A, Tagawa Y, Nagashima H, Kawase M, Yagi K
Interaction of rubratoxin B with serum albumin Mycotoxins,55(1):23-26 2005 Author:Kagaya N, Kamiyoshi A, Tagawa Y, Nagashima H, Kawase M, Yagi K
Suppression of cell death in primary rat hepatocytes by a1-acid glycoprotein J Biosci Bioeng,99(1):81-83 2005 Author:Kagaya N, Kamiyoshi A, Tagawa Y, Akamatsu S, Isoda K, Kawase M, Yagi K
Effect of zinc on hepatoprotectivity of a1-acid glycoprotein Biomedical Research on Trace Elements,16(4):299-301 2005 Author:Kawase M, Kagaya N, Kamiyoshi A, Tagawa Y, Yagi K
Crucial roles of mesodermal cell lineages in a murine embryonic stem cell-derived in vitro liver organogenesis system STEM CELLS,23(7):903-913 2005 Author:Ogawa S, Tagawa Y, Kamiyoshi A, Suzuki A, Nakayama J, Hashikura Y, Miyagawa S
Liver organogenesis from murine embryonic stem cells - A substitute system for an animal experiment HEPATOLOGY,42(4):746A-747A 2005 Author:Ogawa S, Tagawa Y, Kamiyoshi A, Motoyama H, Tsutsui M, Sato F, Nishiyama M, Nakayama J, Hashikura Y, Miyagawa S
Liver protection by bis(maltolato)zinc(II) complex Exp Anim,53(1):1-9 2004 Author:Kawase M, Kagaya N, Akamatsu S, Kamiyoshi A, Muto S, Tagawa Y, Yagi K
Novel function of rare catechin, epigallocatechin-3-(3"-O-methyl)gallate, against cold injury in primary rat hepatocytes J Biosci Bioeng,96(6):559-563 2003 Author:Kagaya N, Hara Y, Saijo R, Kamiyoshi A, Tagawa Y, Kawase M, Yagi K
Survival and function of mouse embryonic stem cell-derived cardiomyocytes in ectopic transplants CARDIOVASCULAR RESEARCH,58(2):435-443 2003 Author:Johkura K, Cui L, Suzuki A, Teng RF, Kamiyoshi A, Okamura S, Kubota S, Zhao X, Asanuma K, Okouchi Y, Ogiwara N, Tagawa Y, Sasaki K
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