Receptor activity-modifying proteins of adrenomedullin (RAMP2/3): Roles in the pathogenesis of ARDS
Kasahara T, Tanaka M, Zhao Y, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Matsuda Y, Zhang Y, Guo Q, Li P, Hoshiyama K, Li J, Onishi N, Hayashi M, Sanjo H, Ishida K, Tanaka S, Kawamata M, Shindo T
Peptides, 171, 171118, 2024年01月
Role of adrenomedullin 2/Intermedin in the pathogenesis of neovascular age-related macular degeneration
Kakihara S, Matsuda Y, Hirabayashi K, Imai A, Iesato Y, Sakurai T, Kamiyoshi A, Tanaka M, Ichikawa-Shindo Y, Kawate H, Zhao Y, Zhang Y, Guo Q, Li P, Onishi N, Murata T, Shindo T
Lab Invest, 103(4), 100038, 2023年04月
Receptor activity modifying protein RAMP sub-isoforms and their functional differentiation, which regulates functional diversity of adrenomedullin
Shindo T, Tanaka M, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Sakurai T.
Biology, 11(5), 788, 2022年05月
Adrenomedullin ameliorates pulmonary fibrosis by regulating TGF-β-Smads signaling and myofibroblast differentiation
Wei Y, Tanaka M, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Cui N, Kakihara S, Zhao Y, Aruga K, Sanjo H, Shindo T.
Endocrinology, 162(8), bqab090, 2021年08月
Adrenomedullin-Receptor Activity-Modifying Protein 2 System Ameliorates Subretinal Fibrosis by Suppressing Epithelial-Mesenchymal Transition in Age-Related Macular Degeneration
Tanaka M, Kakihara S, Hirabayashi K, Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Cui N, Wei Y, Zhao Y, Aruga K, Yamauchi A, Murata T, Shindo T.
Am J Pathol, 191(4), 652-668, 2021年04月
Adrenomedullin-RAMP2 and -RAMP3 Systems Regulate Cardiac Homeostasis during Cardiovascular Stress
Cui N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Tanaka M, Wei Y, Kakihara S, Zhao Y, Aruga K, Kawagishi H, Nakada T, Yamada M, Shindo T.
Endocrinology, 162(3), bqab001, 2021年03月
Deficiency of the adrenomedullin-RAMP3 system suppresses metastasis through the modification of cancer-associated fibroblasts
Dai K, Tanaka M, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Cui N, Wei Y, Tanaka M, Kakihara S, Matsui S, Shindo T.
Oncogene, 39(9), 1914-1930, 2020年02月
Production of genetically engineered mice with higher efficiency, lower mosaicism, and multiplexing capability using maternally expressed Cas9
Sakurai T, Kamiyoshi A, Kawate H, Watanabe S, Sato M, Shindo T.
Sci Rep, 10(1), 1091, 2020年01月
Endogenous Calcitonin Gene-Related Peptide Deficiency Exacerbates Postoperative Lymphedema by Suppressing Lymphatic Capillary Formation and M2 Macrophage Accumulation
Matsui S, Tanaka M, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Dai K, Cui N, Wei Y, Tanaka M, Kakihara S, Nakamura K, Yamauchi A, Ishida K, Tanaka S, Kawamata M, Shindo T.
Am J Pathol, 189(12), 2487-2502, 2019年12月
Bindel-PCR: a novel and convenient method for identifying CRISPR/Cas9-induced biallelic mutants through modified PCR using Thermus aquaticus DNA polymerase
Sakurai T, Kamiyoshi A, Takei N, Watanabe S, Sato M, Shindo T.
Sci Rep, 9(1), 9923, 2019年07月09日
Development of a Novel Model of Central Retinal Vascular Occlusion and the Therapeutic Potential of the Adrenomedullin-Receptor Activity-Modifying Protein 2 System
Hirabayashi, Kazutaka; Tanaka, Masaaki; Imai, Akira; Toriyama, Yuichi; Iesato, Yasuhiro; Sakurai, Takayuki; Kamiyoshi, Akiko; Ichikawa-Shindo, Yuka; Kawate, Hisaka; Tanaka, Megumu; Dai, Kun; Cui, Nanqi; Wei, Yangxuan; Nakamura, Keisei; Iida, Shiho; Matsui, Shuhei; Yamauchi, Akihiro; Murata, Toshinori; Shindo, Takayuki;
AMERICAN JOURNAL OF PATHOLOGY, 189(2), 449-466, 2019年02月
Regulation of cardiovascular development and homeostasis by the adrenomedullin-RAMP system
Shindo, Takayuki; Tanaka, Megumu; Kamiyoshi, Akiko; Ichikawa-Shindo, Yuka; Kawate, Hisaka; Yamauchi, Akihiro; Sakurai, Takayuki;
PEPTIDES, 111, 55-61, 2019年01月
RAMP3 deficiency enhances postmenopausal obesity and metabolic disorders
Liu, Teng; Kamiyoshi, Akiko; Tanaka, Megumu; Iida, Shiho; Sakurai, Takayuki; Ichikawa-Shindo, Yuka; Kawate, Hisaka; Hirabayashi, Kazutaka; Dai, Kun; Cui, Nanqi; Tanaka, Masaaki; Wei, Yangxuan; Nakamura, Keisei; Matsui, Shuhei; Yamauchi, Akihiro; Shindo, Takayuki;
PEPTIDES, 110, 10-18, 2018年12月
Endogenous calcitonin gene-related peptide suppresses ischemic brain injuries and progression of cognitive decline.
Zhai L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Xian X, Hirabayashi K, Dai K, Cui N, Tanimura K, Liu T, Wei Y, Tanaka M, Tomiyama H, Yamauchi A, Igarashi K, Shindo T.
J Hypertens, 36(4), 876-891, 2018年04月
Placental extract ameliorates non-alcoholic steatohepatitis (NASH) by exerting protective effects on endothelial cells.
Yamauchi A, Kamiyoshi A, Koyama T, Iinuma N, Yamaguchi S, Miyazaki H, Hirano E, Kaku T, Shindo T.
Heliyon, 3(9), e00416, 2017年09月27日
Adrenomedullin Suppresses Vascular Endothelial Growth Factor-Induced Vascular Hyperpermeability and Inflammation in Retinopathy.
Imai A, Toriyama Y, Iesato Y, Hirabayashi K, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Liu T, Xian X, Zhai L, Dai K, Tanimura K, Liu T, Cui N, Yamauchi A, Murata T, Shindo T.
Am J Pathol, 187(5), 999-1015, 2017年05月
Vasoprotective Activities of the Adrenomedullin-RAMP2 System in Endothelial Cells.
Xian X, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Tanaka M, Koyama T, Kawate H, Yang L, Liu T, Imai A, Zhai L, Hirabayashi K, Dai K, Tanimura K, Liu T, Cui N, Igarashi K, Yamauchi A, Shindo T.
Endocrinology, 158(5), 1359-1372, 2017年05月
Endogenous Calcitonin Gene-Related Peptide Regulates Lipid Metabolism and Energy Homeostasis in Male Mice.
Liu T, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Yang L, Tanaka M, Xian X, Imai A, Zhai L, Hirabayashi K, Dai K, Tanimura K, Liu T, Cui N, Igarashi K, Yamauchi A, Shindo T.
Endocrinology, 158(5), 1194-1206, 2017年05月
A non-inheritable maternal Cas9-based multiple-gene editing system in mice
Sakurai T, Kamiyoshi A, Kawate H, Mori C, Watanabe S, Tanaka M, Uetake R, Sato M, Shindo T
Sci Rep, 6(20011), 2016年
The endothelial adrenomedullin-RAMP2 system regulates vascular integrity and suppresses tumor metastasis
Tanaka M, Koyama T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Liu T, Xian X, Imai A, Zhai L, Hirabayashi K, Owa S, Yamauchi A, Igarashi K, Taniguchi S, Shindo T
Cardiovasc Res, 111(4), 398-409, 2016年
Pathophysiological Function of Endogenous Calcitonin Gene-Related Peptide in Ocular Vascular Diseases
Toriyama Y, Iesato Y, Imai A, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Igarashi K, Tanaka M, Liu T, Xian X, Zhai L, Owa S, Murata T, Shindo T
Am J Pathol, 185(6), 1783-94, 2015年
Adrenomedullin-RAMP2 System in Vascular Endothelial Cells
Koyama T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Shindo T
J Atheroscler Thromb, 22(7), 647-53, 2015年
A single blastocyst assay optimized for detecting CRISPR/Cas9 system-induced indel mutations in mice
Sakurai T, Watanabe S, Kamiyoshi A, Sato M, Shindo T
BMC Biotechnol, 14, 69, 2014年
Adrenomedullin-RAMP2 System Suppresses ER Stress-Induced Tubule Cell Death and Is Involved in Kidney Protection
Uetake R, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Yoshizawa T, Koyama T, Yang L, Toriyama Y, Yamauchi A, Igarashi K, Tanaka M, Kuwabara T, Mori K, Yanagita M, Mukoyama M, Shindo T
PLOS ONE, 9(2), e87667, 2014年
Pathophysiological roles of adrenomedullin-RAMP2 system in acute and chronic cerebral ischemia
Igarashi K, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Toriyama Y, Tanaka M, Liu T, Xian X, Imai A, Zhai L. Owa S, Koyama T, Uetake R, Ihara M, Shindo T
PEPTIDES, 62, 21-31, 2014年
Functional differentiation of RAMP2 and RAMP3 in their regulation of the vascular system
Yamauchi A, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Igarashi K, Toriyama Y, Tanaka M, Liu T, Xian X, Imai A, Zhai L, Owa S, Arai T, Shindo T
J Mol Cell Cardiol, 77, 73-85, 2014年
Vascular Endothelial Adrenomedullin-RAMP2 System Is Essential for Vascular Integrity and Organ Homeostasis
Koyama T, Ochoa-Callejero L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Iinuma N, Arai T, Yoshizawa T, Iesato Y, Lei Y, Uetake R, Okimura A, Yamauchi A, Tanaka M, Igarashi K, Toriyama Y, Kawate H, Adams RH, Kawakami H, Mochizuki N, Martinez A, Shindo T
Circulation, 127(7), 842-853, 2013年
Novel Regulation of Cardiac Metabolism and Homeostasis by the Adrenomedullin-Receptor Activity-Modifying Protein 2 System
Yoshizawa T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Nakada T, Kashihara T, Yamada M, Kawakami H, Nakanishi H, Taguchi R, Nakanishi T, Akazawa H, Shindo T
Hypertension, 61(2), 341-351, 2013年
Endogenous CGRP protects against neointimal hyperplasia following wire-induced vascular injury
Yang L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yoshizawa T, Koyama T, Iesato Y, Uetake R, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Shindo T
J Mol Cell Cardiol, 59, 55-66, 2013年
Adrenomedullin-RAMP2 System Is Crucially Involved in Retinal Angiogenesis
Iesato Y, Toriyama Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yoshizawa T, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Igarashi K, Murata T, Shindo T
Am J Pathol, 182(6), 2380-2390, 2013年
Regulation of adrenomedullin and its family peptide by RAMP system--lessons from genetically engineered mice
Shindo T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Shimoyama N, Iinuma N, Arai T, Miyagawa S
Curr Protein Pept Sci, 14(5), 347-357, 2013年
Adrenomedullin-RAMP2 system in cardiovascular development and homeostasis
Shindo T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y
Current Hypertension Reviews, 7, 217-227, 2011年
Induction of LYVE-1/stabilin-2-positive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling
Arai T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Iinuma N, Iesato Y, Koyama T, Yoshizawa T, Uetake R, Yamauchi A, Yang L, Kawate H, Ogawa S, Kobayashi A, Miyagawa S, Shindo T
PEPTIDES, 32(9), 1855-1865, 2011年
Adrenomedullin in sinusoidal endothelial cells play protective roles against cold injury of liver
Iinuma N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Arai T, Yoshizawa T, Koyama T, Uetake R, Kawate H, Muto S, Tagawa Y, Miyagawa S, Shindo T
PEPTIDES, 31(5), 865-871, 2010年
Endogenous a-calcitonin gene-related peptide mitigates liver fibrosis in chronic hepatitis induced byrepeated administration of concanavalin A
Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Iinuma N, Kawate H, Yoshizawa T, Koyama T, Muto S, Shindo T
Liver Int, 29(5), 642-649, 2009年
GPCRmodulator protein RAMP2 is essential for angiogenesis and vascular integrity
Ichikawa-Shindo Y, Sakurai T, Kamiyoshi A, Kawate H, Iinuma N, Yoshizawa T, Koyama T, Fukuchi J, Iimuro S, Moriyama N, Kawakami H, Murata T, Kangawa K, Nagai R, Shindo T
J Clin Invest, 118(1), 29-39, 2008年
Rapid zygosity determination in mice by SYBR Green real-time genomic PCR of a crude DNA solution
Sakurai T, Kamiyoshi A, Watanabe S, Sato M, Shindo T
Transgenic Res, 17(1), 149-155, 2008年
Endogenous alphaCGRP protects against concanavalin A-induced hepatitis in mice
Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Fukuchi J, Kawate H, Muto S, Tagawa Y, Shindo T
Biochem Biophys Res Commun, 343(1), 152-158, 2006年
Azelnidipine, a long-acting dihydropyridine calcium channel blocker, suppresses the development of cardiac hypertrophy and fibrosis in adrenomedullin knock out mice.
Shindo T, Niu P, Kamiyoshi A, Sakurai T, Ichikawa Y, Iinuma N, Kawate H
Circulation, 114(18), 13-13, 2006年
Characterization of cytochrome P450 expression in murine embryonic stem cell-derived hepatic tissue system
Tsutsui M, Ogawa S, Inada Y, Tomioka E, Kamiyoshi A, Tanaka S, Kishida T, Nishiyama M, Murakami M, Kuroda J, Hashikura Y, Miyagawa S, Satoh F, Shibata N, Tagawa Y
Drug Metabolism and Disposition, 34(4), 696-701, 2006年
Effect of zinc on hepatoprotectivity of a1-acid glycoprotein
Kawase M, Kagaya N, Kamiyoshi A, Tagawa Y, Yagi K
Biomedical Research on Trace Elements, 16(4), 299-301, 2005年
Suppression of cell death in primary rat hepatocytes by a1-acid glycoprotein
Kagaya N, Kamiyoshi A, Tagawa Y, Akamatsu S, Isoda K, Kawase M, Yagi K
J Biosci Bioeng, 99(1), 81-83, 2005年
Interaction of rubratoxin B with serum albumin
Kagaya N, Kamiyoshi A, Tagawa Y, Nagashima H, Kawase M, Yagi K
Mycotoxins, 55(1), 23-26, 2005年
Tea catechin, epigallocatechin-3-gallate, inhibits rubratoxin B-induced apoptosis of hepatocytes through MAPK p38 pathway
Kagaya N, Kamiyoshi A, Tagawa Y, Nagashima H, Kawase M, Yagi K
Mycotoxins, 55(1), 17-22, 2005年
Liver organogenesis from murine embryonic stem cells - A substitute system for an animal experiment
Ogawa S, Tagawa Y, Kamiyoshi A, Motoyama H, Tsutsui M, Sato F, Nishiyama M, Nakayama J, Hashikura Y, Miyagawa S
Hepatology, 42(4), 746A-747A, 2005年
Crucial roles of mesodermal cell lineages in a murine embryonic stem cell-derived in vitro liver organogenesis system
Ogawa S, Tagawa Y, Kamiyoshi A, Suzuki A, Nakayama J, Hashikura Y, Miyagawa S
Stem Cells, 23(7), 903-913, 2005年
Liver protection by bis(maltolato)zinc(II) complex
Kawase M, Kagaya N, Akamatsu S, Kamiyoshi A, Muto S, Tagawa Y, Yagi K
Exp Anim, 53(1), 1-9, 2004年
Novel function of rare catechin, epigallocatechin-3-(3"-O-methyl)gallate, against cold injury in primary rat hepatocytes
Kagaya N, Hara Y, Saijo R, Kamiyoshi A, Tagawa Y, Kawase M, Yagi K
J Biosci Bioeng, 96(6), 559-563, 2003年
Survival and function of mouse embryonic stem cell-derived cardiomyocytes in ectopic transplants
Johkura K, Cui L, Suzuki A, Teng RF, Kamiyoshi A, Okamura S, Kubota S, Zhao X, Asanuma K, Okouchi Y, Ogiwara N, Tagawa Y, Sasaki K
Cardiovascular Research, 58(2), 435-443, 2003年
