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中田勉  ナカダ ツトム

教員組織学術研究院(医学系)電話番号0263-37-2606
教育組織医学部 医学科 分子薬理学FAX番号0263-37-3085
職名講師メールアドレスtnakada@shinshu-u.ac.jp
住所〒3908621 長野県松本市旭3-1-1ホームページURL

更新日:2017/09/20

プロフィール

研究分野
薬理学
分子生物学
現在の研究課題
心筋L型カルシウムチャネルの細胞内局在決定機構の解明

所属学会
所属学会
日本薬理学会
日本循環器学会
学歴
出身大学院
2007 , 東京工業大学

出身学校・専攻等(大学院を除く)
2002 , 東京理科大学

取得学位
博士(理学) , 東京工業大学
研究職歴等
研究職歴
信州大学 医学部 助教

研究活動業績

研究業績(著書・
発表論文等)
論文
Ammonia exposure affects the mRNA and protein expression levels of certain Rhesus glycoproteins in the gills of climbing perch.
J Exp Biol,220(Pt 16):2916-2931 2017(Aug.)
Author:Chen XL, Zhang B, Chng YR, Ong JLY, Chew SF, Wong WP, Lam SH, Nakada T, Ip YK.


Angiotensin II activates Ca(V) 1.2 Ca(2+) channels through β-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes.
J Physiol,595(13):4207-4225 2017(Jul.)
Author:Kashihara T, Nakada T, Kojima K, Takeshita T, Yamada M.


マイクロRNAを標的とした核酸医薬による骨格筋サルコペニア予防・治療法の開発
医科学応用研究財団研究報告,33:296-300 2016(Feb.)
Author:中田勉


β(2)-Adrenergic and M(2)-muscarinic receptors decrease basal t-tubular L-type Ca2+ channel activity and suppress ventricular contractility in heart failure
EUROPEAN JOURNAL OF PHARMACOLOGY,724:122-131 2014(Feb.)
Author:Kashihara, T; Hirose, M; Shimojo, H; Nakada, T; Gomi, S; Hongo, M; Yamada, M


Cardiac overexpression of constitutively active Gαq causes angiotensin II type1 receptor activation, leading to progressive heart failure and ventricular arrhythmias in transgenic mice
PLoS One ,29:e106354 2014
Author:Matsushita N, Kashihara T, Shimojo H, Suzuki S, Nakada T, Takeishi Y, Mende U, Taira E, Yamada M, Sanbe A, Hirose M


横紋筋L型カルシウムチャネルの結合膜局在化機構
日本薬理学雑誌,144:217-221 2014
Author:中田勉,山田充彦


Phlorizin prevents electrically-induced ventricular tachyarrhythmia during ischemia in Langendorff-perfused guinea-pig hearts
Biol Pharm Bull,37:1168-1176 2014
Author:Hirose M, Shibazaki T, Nakada T, Kashihara T, Yano S, Okamoto Y, Isaji M, Matsushita N, Taira E, Yamada M


TRPM4 channels mediate hypertonicity-induced, Ca2+-impermeable, Non-selective cation currents in a cervical cancer cell line, HeLa cells
Shinshu Med J,62:33-44 2014
Author:Gomi S, Nakada T, Kashihara T, Ikeda U, Yamada M


The proximal C-terminus of alpha(1C) subunits is necessary for junctional membrane targeting of cardiac L-type calcium channels
BIOCHEMICAL JOURNAL,448:221-231 2012(Dec.)
Author:Nakada, Tsutomu; Flucher, Bernhard E.; Kashihara, Toshihide; Sheng, Xiaona; Shibazaki, Toshihide; Horiuchi-Hirose, Miwa; Gomi, Simmon; Hirose, Masamichi; Yamada, Mitsuhiko


Two mechanistically distinct effects of dihydropyridine nifedipine on Ca(V)1.2 L-type Ca(2+) channels revealed by Timothy syndrome mutation
Eur J Pharmacol,685(1-3):15-23 2012(Jun. 15)
Author:Xiaona Sheng, Tsutomu Nakada, Motohiro Kobayashi, Toshihide Kashihara, Toshihide Shibazaki, Miwa Horiuchi-Hirose, Simmon Gomi, Masamichi Hirose, Toshifumi Aoyama, and Mitsuhiko Yamada


Expression of long-form N-acetylglucosamine-6-O-sulfotransferase 1 in human high endothelial venules
J Histochem Cytochem,60(5):397-407 2012(Apr. 25)
Author:Maiko Fujiwara, Motohiro Kobayashi, Hitomi Hoshino, Kenji Uchimura, Tsutomu Nakada, Junya Masumoto, Yasuhiro Sakai, Minoru Fukuda, and Jun Nakayama


Chronic receptor-mediated activation of Gi/o proteins alters basal t-tubular and sarcolemmal L-type Ca²⁺ channel activity through phosphatases in heart failure
Am J Physiol Heart Circ Physiol,302(8):H1645-1654 2012(Apr. 15)
Author:Toshihide Kashihara, Tsutomu Nakada, Hisashi Shimojo, Miwa Horiuchi-Hirose, Simmon Gomi, Toshihide Shibazaki, Xiaona Sheng, Masamichi Hirose, Minoru Hongo, and Mitsuhiko Yamada


Nicorandil ameliorates impulse conduction disturbances during ischemia in isolated arterially perfused canine atria.
Int. J. Cardiol.,146:37–43 2011
Author:Hirose M, Yano S, Nakada T, Horiuchi-Hirose M, Tsujino N, Yamada M


Decrease in the density of t-tubular L-type Ca2+ channel currents in failing ventricular myocytes
Am. J. Physiol. Heart Circ. Physiol.,300:H978–H988 2011
Author:Horiuchi-Hirose M, Kashihara T, Nakada T, Kurebayashi N, Shimojo H, Shibazaki T, Sheng X, Yano S, Hirose M, Hongo M, Sakurai T, Moriizumi T, Ueda H, Yamada M


Selective α1A-adrenoceptor stimulation induces Mueller’s smooth muscle contraction in an isolated canine upper eyelid preparation.
Curr. Eye Res.,35(5):363–369 2010
Author:Yano S, Hirose M, Nakada T, Nakayama J, Matsuo K, Yamada M.


Rh glycoprotein expression is modulated in pufferfish (Takifugu rubripes) during high environmental ammonia exposure.
J. Exp. Biol.,213:3150-3160 2010
Author:Nawata CM, Hirose S, Nakada T, Wood CM, Kato A.


Rhesus glycoprotein p2 (Rhp2) is a novel member of the Rh family of ammonia transporters highly expressed in shark kidney.
J. Biol. Chem.,285:2653-2664 2010
Author:Nakada T, Westhoff CM, Yamaguchi Y, Hyodo S, Li X, Muro T, Kato A, Nakamura N, Hirose S


Diacylglycerol kinase ζ inhibits Gαq-induced atrial remodeling in transgenic mice.
Heart rhythm,6:78-84 2009
Author:Hirose M, Takeishi Y, Niizeki T, Shimojo H, Nakada T, Kubota I, Nakayama J, Mende U, Yamada M.


Identification of renal transporters involved in sulfate excretion in marine teleost fish.
Am. J. Physiol. Regul. Integr. Comp. Physiol.,297:R1647–R1659 2009
Author:Kato A, Chang MH, Kurita Y, Nakada T, Ogoshi M, Nakazato T, Doi H, Hirose S, Romero MF.


Mechanisms of preventive effect of nicorandil on ischemia-induced ventricular tachyarrhythmia in isolated arterially perfused canine left ventricular.
Basic Clin. Pharmacol. Toxiocol.,102:504-514 2008
Author:Hirose M, Tsujino N, Nakada T, Yano S, Imamura H, Yamada M.


Contribution of L-type Ca2+ channels to early afterdepolarizations induced by IKr and IKs channel suppression in guinea-pig ventricular myocytes.
J. Membr. Biol.,222:151-166 2008
Author:Yamada M, Ohta K, Niwa A, Tsujino N, Nakada T, Hirose M.


Identification of intestinal bicarbonate transporters involved in formation of carbonate precipitates to stimulate water absorption in marine teleost fish.
Am. J. Physiol. Regul. Integr. Comp. Physiol.,294:R1402-R1412 2008
Author:Kurita Y, Nakada T, Kato A, Doi H, Mistry AC, Chang MH, Romero MF, Hirose S.


Ammonia secretion from fish gill depends on a set of Rh glycoproteins.
FASEB J.,21:1067-1074 2007
Author:NakadaT, Westhoff CM, Kato A, Hirose S.


Localization of ammonia transporter Rhcg1 in mitochondrion-rich cells of yolk sac, gill, and kidney of zebrafish and its ionic strength-dependent expression.
Am. J. Physiol. Regul. Integr. Comp. Physiol.,293:1743-1753 2007
Author:Nakada T, Hoshijima K, Esaki M, Nagayoshi S, Kawakami K, Hirose S.


Molecular and functional characterization of adrenomedullin receptors in pufferfish.
Am. J. Physiol. Regul. Integr. Comp. Physiol.,290:R467-R478 2006
Author:Nag K, Kato A, Nakada T, Hoshijima K, Mistry AC, Takei Y, Hirose S.


学会発表
生活習慣病に対する治療戦略 循環器疾患 幼若心筋細胞におけるAT1受容体/βアレスチン2を介した新しい陽性変力反応の機序の解析
応用薬理 , 89(1-2):42 2015(Aug.)
Author:山田充彦, 柏原俊英, 中田勉