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新井 亮一  アライ リョウイチ

教員組織学術研究院(繊維学系)電話番号
教育組織繊維学部 応用生物科学科FAX番号
職名准教授メールアドレスrarai[at]shinshu-u.ac.jp
住所〒386-8567 長野県上田市常田3-15-1ホームページURLhttp://fiber.shinshu-u.ac.jp/arai/

更新日:2018/08/21

プロフィール

兼担研究科・学部
菌類・微生物ダイナミズム創発研究センター 超分子複合体部門 兼任(部門長)
研究分野
タンパク質工学,構造生物学,生物工学,合成生物学
現在の研究課題
タンパク質のX線結晶構造解析

人工タンパク質の設計開発

改変・融合タンパク質の構築と応用

所属学会
所属学会
日本蛋白質科学会
日本生物工学会
日本分子生物学会
酵素工学研究会
「細胞を創る」研究会
学歴
出身大学院
2001 , 東京大学 , 工学系研究科 , 化学生命工学専攻
1998 , 東京大学 , 工学系研究科 , 化学生命工学専攻

出身学校・専攻等(大学院を除く)
1996 , 東京大学 , 工学部 , 化学生命工学科

取得学位
博士(工学) , 東京大学
受賞学術賞
2015 , 酵素工学奨励賞 , 「配列パターンデザインによる新規人工設計タンパク質の半合理的創製と構造解析およびナノ構造構築への応用」
2013 , 第13回リバネス研究費Direct Detect賞
2011 , PDB40 Travel Award , Protein Data Bank 40th Anniversary Symposium
2011 , Protein Science Young Investigator Travel Grant / The Protein Society Finn Wold Travel Award , IX European Symposium of The Protein Society
2001 , 平成12年度石井学術奨励賞
1996 , 平成8年度化学工学会関東支部長賞(学生賞)
研究職歴等
研究職歴
2016- , 信州大学学術研究院(繊維学系) 准教授
2016- , 信州大学菌類・微生物ダイナミズム創発研究センター 超分子複合体部門 部門長(兼任)
2013- , 理化学研究所ライフサイエンス技術基盤研究センター 客員研究員兼務
2014-2016 , 信州大学学術研究院(繊維学系) 助教
2012-2014 , 信州大学繊維学部 助教
2007-2012 , 信州大学ファイバーナノテク国際若手研究者育成拠点 助教(テニュアトラック)
2006-2007 , 日本学術振興会 海外特別研究員
2004-2006 , 理化学研究所ゲノム科学総合研究センター 研究員
2001-2006 , 理化学研究所播磨研究所ストラクチュローム研究グループ兼務
2001-2004 , 理化学研究所ゲノム科学総合研究センター リサーチアソシエイト
1998-2001 , 日本学術振興会 特別研究員(DC1)

留学歴
2006-2007 , 米国プリンストン大学化学科

研究活動業績

研究業績(著書・
発表論文等)
著書
Characterization of underwater silk proteins from caddisfly larva, Stenopsyche marmorata
Springer, New York , Biotechnology of Silk: Biologically inspired systems Volume 5 , :Ch. 6, pp. 107-122 2013
Author:Ohkawa, K., Nomura, T., Arai, R., Hirabayashi, K., Tsukada, M., and Abe , K.


蛋白質-蛋白質相互作用「Tagged-MS法」
共立出版 , 蛋白質核酸酵素(増刊号)「ゲノムネットワーク」 , 49:2763-2767 2004
Author:新井亮一,白水美香子,横山茂之,廣田 洋


GFPの検出およびイメージング技術「分子間相互作用解析実験」
羊土社 , 実験医学別冊「GFPとバイオイメージング , :207-214 2000
Author:新井亮一,上田 宏,長棟輝行


論文
Design of hollow protein nanoparticles with modifiable interior and exterior surfaces
Angewandte Chemie International Edition,:in press 2018
Author:Norifumi Kawakami, Hiroki Kondo, Yuki Matsuzawa, Kaoru Hayasaka, Erika Nasu, Kenji Sasahara, Ryoichi Arai, Kenji Miyamoto


Self-assembling supramolecular nanostructures constructed from de novo extender protein nanobuilding blocks
ACS Synthetic Biology,7(5):1381-1394 2018
Author:Naoya Kobayashi, Kouichi Inano, Kenji Sasahara, Takaaki Sato, Keisuke Miyazawa, Takeshi Fukuma, Michael H Hecht, Chihong Song, Kazuyoshi Murata, and Ryoichi Arai


Hierarchical design of artificial proteins and complexes toward synthetic structural biology
Biophysical Reviews,10:391-410 2018
Author:Arai, R.


Comparative analysis of plant isochorismate synthases reveals structural mechanisms underlying their distinct biochemical properties
Bioscience Reports,38:BSR20171457 2018
Author:2. Yokoo, S., Inoue, S., Suzuki, N., Amakawa, N., Matsui, H., Nakagami, H., Takahashi, A., Arai R. and Katou, S.


Design and construction of self-assembling supramolecular protein complexes using artificial and fusion proteins as nanoscale building blocks
Current Opinion in Biotechnology,46:57–65 2017
Author:Kobayashi, N. and Arai, R.


バイナリーパターン配列デザインによるデノボ蛋白質の創出と蛋白質ナノブロックによる超分子複合体の創生
生物工学会誌,94:485-488 2016
Author:小林直也,木村尚弥,新井亮一


二量体形成新規人工タンパク質を用いたタンパク質ナノブロック開発による自己組織化ナノ構造複合体の創製
分子研レターズ,73:30–31 2016
Author:小林直也,新井亮一


Flight density of the aquatic insect fauna over the water surface in the middle reaches of the Shinano River, Japan, mainly among caddisflies (Trichoptera)
Zoosymposia,10:203–213 2016
Author:Hirabayashi, K.*, Ikutama, E., Ohkawa, K., Arai, R., Nomura, T., Tsukada, M., and Abe, K.


Characterization of silk gland ribosomes from a bivoltine caddisfly, Stenopsyche marmorata: translational suppression of a silk protein in cold conditions.
Biochemical and Biophysical Research Communications,469:210-215 2016
Author:Takaomi Nomura, Miho Ito, Mai Kanamori, Yuta Shigeno, Toshio Uchiumi, Ryoichi Arai, Masuhiro Tsukada, Kimio Hirabayashi, Kousaku Ohkawa


Expression, purification, crystallization and X-ray diffraction analysis of ChiL, a chitinase from Chitiniphilus shinanonensis
Acta Cryst. F,F71(12):1516–1520 2015(Dec.)
Author:Miruku Ueda, Makoto Shimosaka and Ryoichi Arai


Molecular cloning, gene expression analysis, and recombinant protein expression of novel silk proteins from larvae of a retreat-maker caddisfly, Stenopsyche marmorata
Biochem. Biophys. Res. Commun.,464(3):814–819 2015
Author:Xue Bai, Mayo Sakaguchi, Yuko Yamaguchi, Shiori Ishihara, Masuhiro Tsukada, Kimio Hirabayashi, Kousaku Ohkawa, Takaomi Nomura, Ryoichi Arai


Self-Assembling Nano-Architectures Created from a Protein Nano-Building Block Using an Intermolecularly Folded Dimeric De Novo Protein
J. Am. Chem. Soc.,137(35):11285–11293 2015
Author:Naoya Kobayashi, Keiichi Yanase, Takaaki Sato, Satoru Unzai, Michael H. Hecht, Ryoichi Arai


Crystal structure of ChiL, a chitinase from Chitiniphilus shinanonensis
Photon Factory Activity Report 2014,32(B):206 2015
Author:Ueda, M., Shimosaka, M., and Arai, R.


Crystal structure of Fab fragment of an anti-Osteocalcin C-Terminal peptide antibody KTM219
Photon Factory Activity Report 2014,32(B):205 2015
Author:Komatsu, M., Dong, J., Ueda, H., and Arai, R.


Crystal structure of glycine oxidase from Geobacillus kaustophilus
Photon Factory Activity Report 2014,32(B):204 2015
Author:Shiono, T., Nomura, T., Nishiya, Y., and Arai, R.


Intermolecular interactions and molecular dynamics in bovine serum albumin solutions studied by small angle X-ray scattering and dielectric relaxation spectroscopy.
J. Mol. Liq.,200(A):59-66 2014
Author:Yanase, K., Arai R., and Sato, T.


Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies.
Hum. Mol. Genet.,23:6495-6511 2014
Author:Shimamoto C, Ohnishi T, Maekawa M, Watanabe A, Ohba H, Arai R, Iwayama Y, Hisano Y, Toyota T, Toyoshima M, Suzuki K, Shirayama Y, Nakamura K, Mori N, Owada, Y, Kobayashi T, and Yoshikawa T


Crystal structure of glycine oxidase from Bacillus thuringiensis
Photon Factory Activity Report 2013,31(B):274 2014
Author:Ohishi, S., Shiono, T., Nishiya, Y., Nomura, T., and Arai, R.


バイナリーパターンデザインによるデノボタンパク質WA20のドメインスワップ二量体構造
酵素工学研究会誌,69:19-25 2013
Author:小林直也,*新井亮一


Chain conformational study on underwater silk protein from caddisfly, Stenopsyche marmorata: Implication of a fiber-forming mechanism
Adv. Mater. Res.,796:41706 2013
Author:Ohkawa, K., Hachisu, M., Nomura, T., Arai, R., Hirabayashi, K., Tsukada, M., and Abe, K


Long-range periodic sequence of Stenopsyche marmorata cement/silk protein: Purification and biochemical characterization
Biofouling,29(4):357-367 2013
Author:Ohkawa, K., Miura, Y., Nomura, T., Arai, R., Abe, K., Tsukada M. and Hirabayashi, K.


Isolation of silk proteins from a caddisfly larva, Stenopsyche marmorata.
J. Fiber Bioeng. Informatics,5:125-137 2012
Author:Ohkawa, K., Miura, Y., Nomura, T., Arai, R., Abe, K., Tsukada M. and Hirabayashi, K.


Solution structure of IseA, an inhibitor protein of DL-endopeptidases from Bacillus subtilis, reveals a novel fold with a characteristic inhibitory loop
J. Biol. Chem.,287(53):44736-44748 2012
Author:Arai, R., Fukui, S., Kobayashi, N. and Sekiguchi, J.


Domain-Swapped Dimeric Structure of a Stable and Functional De Novo 4-Helix Bundle Protein, WA20
J. Phys. Chem. B,116(23):6789-6797 2012
Author:Arai, R., Kobayashi, N., Kimura, A., Sato, T., Matsuo, K., Wang, A.F., Platt, J.M., Bradley, L.H., Hecht, M.H.


Crystal structure of a menaquinone biosynthetic enzyme, TthMqnD, complexed with its product, 1,4-dihydroxy-6-naphthoate
Photon Factory Activity Report 2010,28:B298 2011
Author:Matsuo, K., Dairi, T., Seto, H. and Arai, R.


Crystal structure of a dimeric de novo 4-helix bundle protein, WA20
Photon Factory Activity Report 2010,28:B256 2011
Author:Arai, R., Kobayashi, N., Kimura, A., Sato, T., Wang, A.F., Platt, J.M., Bradley, L.H. and Hecht, M.H.


Dissecting cell signaling pathways with genetically encoded 3-iodo-L-tyrosine
ChemBioChem,12:387-389 2011
Author:Hayashi A, Hino N, Kobayashi T, Arai R, Shirouzu M, Yokoyama S, Sakamoto K.


Polymorphism screening of brain-expressed FABP7, 5 and 3 genes and association studies in autism and schizophrenia in Japanese subjects
J. Hum. Genet.,55:127-130 2010
Author:Maekawa, M.,Iwayama, Y., Arai, R., Nakamura, K., Ohnishi, T., Toyota, T., Tsujii, M., Okazaki, Y., Osumi, N., Owada, Y., Mori, N., and Yoshikawa, T.


Crystal structure of MqnD (TTHA1568), a menaquinone biosynthetic enzyme from Thermus thermophilus HB8
J. Struct. Biol,168:575-581 2009
Author:Arai, R., Murayama, K., Uchikubo-Kamo, T., Nishimoto, M., Toyama, M., Kuramitsu, S., Terada, T., Shirouzu, M. and Yokoyama, S.


Fabp7 Maps to a Quantitative Trait Locus for a Schizophrenia Endophenotype
PLoS Biol.,5:e297 2007
Author:Watanabe, A., Toyota, T., Owada, Y., Hayashi, T., Iwayama, Y., Matsumata, M., Ishitsuka, Y., Nakaya, A., Maekawa, M., Ohnishi, T., Arai, R., Sakurai, K., Yamada, K., Kondo, H., Hashimoto, K., Osumi, N. and Yoshikawa T.


Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures
Proteins,67:732-742 2007
Author:Arai, R.,* Ito, K.,* Ohnishi, T., Ohba, H., Akasaka, R., Bessho, Y., Hanawa-Suetsugu, K., Yoshikawa, T., Shirouzu, M. and Yokoyama, S.


Structure of archaeal glyoxylate reductase from Pyrococcus horikoshii OT3 complexed with nicotinamide adenine dinucleotide phosphate
Acta Crystallogr. D,63:357-365 2007
Author:Yoshikawa, S.,* Arai, R.,* Kinoshita, Y., Uchikubo-Kamo, T., Wakamatsu, T., Akasaka, R., Masui, R., Terada, T., Kuramitsu, S., Shirouzu, M. and Yokoyama, S. (*The authors contributed equally to the work.)


Crystal structure of the conserved protein TTHA0727 from Thermus thermophilus HB8 at 1.9 A resolution: A CMD family member distinct from carboxymuconolactone decarboxylase (CMD) and AhpD
Protein Sci.,15:1187-1192 2006
Author:Ito, K.,* Arai, R.,* Fusatomi, E., Kamo-Uchikubo, T., Kawaguchi, S., Akasaka, R., Terada, T., Kuramitsu, S., Shirouzu, M. and Yokoyama, S.


Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7)
Acta Crystallogr. F,62:330-334 2006
Author:Arai, R.,* Yoshikawa, S.,* Murayama, K., Imai, Y., Takahashi, R., Shirouzu, M. and Yokoyama, S.


Crystal structure of the probable haloacid dehalogenase PH0459 from Pyrococcus horikoshii OT3
Protein Sci.,15:373-377 2006
Author:Arai, R., Kukimoto-Niino, M., Kuroishi, C., Bessho, Y., Shirouzu, M. and Yokoyama, S.


Crystal structure of an enhancerof rudimentary homolog (ERH) at 2.1 Angstroms resolution
Protein Sci.,14:1888-1893 2005
Author:Arai, R., Kukimoto-Niino, M., Uda-Tochio, H., Morita, S., Uchikubo-Kamo, T., Akasaka, R., Etou, Y., Hayashizaki, Y., Kigawa, T., Terada, T., Shirouzu, M. and Yokoyama, S.


Conserved protein TTHA1554 from Thermus thermophilus HB8 binds to glutamine synthetase and cystathionine beta-lyase
Biochim. Biophys. Acta,1750:40-47 2005
Author:Arai, R.,* Nishimoto, M.,* Toyama, M., Terada, T., Kuramitsu, S., Shirouzu, M. and Yokoyama, S. Conserved protein TTHA1554 from Thermus thermophilus HB8 binds to glutamine synthetase and cystathionine beta-lyase


Establishment of stable hFis1 knockdown cells with an siRNA expression vector
J. Biochem.,136:421-425 2004
Author:Arai, R.,* Ito,K.,* Wakiyama, M., Matsumoto, E., Sakamoto, A., Etou, Y., Otsuki, M., Inoue, M., Hayashizaki, Y., Miyagishi, M., Taira, K., Shirouzu, M. and Yokoyama, S.


Phosphorylation analysis of 90 kDa heat shock protein within the cytosolic arylhydrocarbon receptor complex
Biochemistry,43:15510-15519 2004
Author:Ogiso, H., Kagi, N., Matsumoto, E., Nishimoto, M., Arai, R., Shirouzu, M., Mimura, J., Fujii-Kuriyama, Y. and Yokoyama, S.


Conformations of variably linked chimeric proteins evaluated by synchrotron X-ray small-angle scattering
Proteins,57:829-838 2004
Author:Arai, R., Wriggers, W., Nishikawa, Y., Nagamune, T. and Fujisawa, T.


An optimized homogeneous noncompetitive immunoassay based on the antigen-driven enzymatic complementation
J. Immunol. Methods,279:209-218 2003
Author:Ueda, H., Yokozeki, T., Arai, R., Tsumoto, K., Kumagai, I. and Nagamune, T.


A homogeneous noncompetitive immunoassay for the detection of small haptens
Anal. Chem.,74:2500-2504 2002
Author:Yokozeki, T., Ueda, H., Arai, R., Mahoney, W. and Nagamune, T.


A homogeneous and noncompetitive immunoassay based on the enhanced fluorescence resonance energy transfer by leucine zipper interaction
Anal. Chem.,74:5786-5792 2002
Author:Ohiro, Y., Arai, R., Ueda, H. and Nagamune, T.


Detection of protein-protein interaction by bioluminescence resonance energy transfer from firefly luciferase to red fluorescent protein
J. Biosci. Bioeng.,94:362-364 2002
Author:Arai, R., Nakagawa, H., Kitayama, A., Ueda, H. and Nagamune, T


Demonstration of a homogeneous noncompetitive immunoassay based on bioluminescence resonance energy transfer
Anal. Biochem.,289:77-81 2001
Author:Arai, R., Nakagawa, H., Tsumoto, K., Mahoney, W., Kumagai, I., Ueda, H. and Nagamune, T.


Design of the linkers which effectively separate domains of a bifunctional fusion protein
Protein Eng.,14:529-532 2001
Author:Arai, R., Ueda, H., Kitayama, A., Kamiya, N. and Nagamune, T.


Construction of green fluorescent protein reporter genes for genotoxicity test (SOS/umu-Test) and improvement of mutagen-sensitivity
J. Biosci. Bioeng,92:301-304 2001
Author:Arai, R., Makita, Y., Oda, Y. and Nagamune, T.


Design of an artificial light-harvesting unit by protein engineering: Cytochrome b(562)-green fluorescent protein chimera
Biochem. Biophys. Res. Commun.,289:299-304 2001
Author:Takeda, S., Kamiya, N., Arai, R. and Nagamune, T.


Fluorolabeling of antibody variable domains with green fluorescent protein variants: application to an energy transfer-based homogeneous immunoassay
Protein Eng.,13:369-376 2000
Author:Arai, R., Ueda, H., Tsumoto, K., Mahoney, W.C., Kumagai, I. and Nagamune, T.


Construction of chimeric proteins between protein G and fluorescence-enhanced green fluorescent protein, and their application to immunoassays
J. Ferment. Bioeng.,86:440-445 1998
Author:Arai, R., Ueda, H. and Nagamune, T.


学会発表
Molecular cloning of novel silk proteins from larvae of caddisfly, Stenopsyche marmorata
8th Chaina International Silk Conference 2013 , :ISC1-001 2013
Author:K. Ohkawa, M. Hachisu, T.Nomura, R.Arai, K. Hirabayashi, M. Tsukada and K. Abe


Molecular cloning of novel silk proteins from larvae of caddisfly, Stenopsyche marmorata
Young Researcher Symposium 2013 , :117-118 2013
Author:X.Bai, K.Ohkawa, T.Nomura, S.Ishihara, Y.Yamaguchi, M.Tsukada, K.Abe, K.Hirabayashi, R. Arai


Construction and characterization of tandem WA20 domain-swapped de novo proteins with various linkers.
27th Annual Symposium of The Protein Society. 2013
Author:Naoya Kobayashi, N., Michael H. Hecht, and Ryoichi Arai


Biochemical natures of underwater silk proteins from caddisfly, Stenopsyche marmorata
The international Textile Conference 2013 , :p. 90 2013
Author:Kousaku Ohkawa, Masakazu Hachisu, Takaomi Nomura, Ryoichi Arai, Masuhiro Tsukada and Kimio Hirabayashi


Characterization and Nanofiber Fabrication of Underwater Silk Protein from Stenopsyche marmorata
American Chemical Society, National Meething, 2013 Spring , :Paper ID 18339 2013
Author:Kousaku Ohkawa, Yumi Miura, Takaomi Nomura, Ryoichi Arai, Kimio Hirabayashi, Masuhiro Tsukada, and Koji Abe


Structural and functional analyses of binary pattern designed de novo proteins
Enzyme Engineering XXII 2013
Author:Arai, R. Kobayashi, N., Fukuda, S., Kurasawa, S. and Hecht, M. H.


Solution structure of IseA, an inhibitor protein of DL-endopeptidases from Bacillus subtilis, reveals a novel fold with a characteristic inhibitory loop
International Conference on Structural Genomics 2013 (ICSG2013) 2013
Author:Arai, R., Fukui, S., Kobayashi, N. and Sekiguchi, J.


A De Novo Heme Protein, Dnhps1, Created from a 5-Amino Acid Alphabet
27th Annual Symposium of The Protein Society 2013
Author:Fukuda, S., Kurasawa, S., and Arai, R.


Crystal structures of MqnD, a menaquinone biosynthetic enzyme, complexed with the product, 1,4-dihydroxy-6-naphthoate, and its analogs
4th International Symposium on Diffraction Structural Biology 2013 (ISDSB2013) 2013
Author:Arai, R., Matsuo, K. and Dairi, T.


Isolation of silk proteins from a caddisfly larva, Stenopsyche marmorata
Textile Bioengneering Informatics Symposium 2012 , :233–242 2012
Author:Kousaku Ohkawa, Yumi Miura, Takaomi Nomura, Ryoichi Arai, Koji Abe, Masuhiro Tsukada and Kimio Hirabayashi


Underwater silk fibers–Biochemical natures for novel textile technology
9th Asia-Pacific Marine Biotechnogy Conference , :P-059 2012
Author:Kousaku Ohkawa, Yumi Miura, Takaomi Nomura, Ryoichi Arai, Koji Abe, Masuhiro Tsukada and Kimio Hirabayashi


Domain-Swapped Dimeric Structure of a Stable and Functional De Novo Four-Helix Bundle Protein WA20, and its Potential Application
18th Symposium of Young Asian Biochemical Engineers' Community (YABEC2012) , :PC-8 2012
Author:Arai, R., Kobayashi, N., Kimura, A., Sato, T., and Hecht, M. H.


De novo proteins and interaction analysis using pattern-designed peptide libraries
Gordon Research Conference, Intrinsically Disordered Proteins 2012
Author:Arai, R., Kobayashi, N., Kimura, A., Teranishi, H., Sato, T., Bradley, L. H., Nishimura, Y., and Hecht, M. H.


Flight density of aquatic insects fauna over river water surface in the middle reaches of the Shinano River, Japan, with emphasis on Trichoptera.
14th International symposium on Trichoptera 2012
Author:Hirabayashi K., Ohkawa K., Arai R., Nomura T., Tsukada M. and Abe K.


Function and Three Dimensional Structure of an Autolysin Inhibitor IseA from Bacillus subtilis
American Society for Microbiology, General Meeting (asm2012) 2012
Author:Junichi Sekiguchi and Ryoichi Arai


Repetitive Sequential Motifs of Underwater Silk Protein from Caddisfly, Stenopsyche marmorata, 
American Chemical Society, Annual Meeting Spring 2012 , :BIOL163 2012
Author:Kousaku OHKAWA, Yumi MIURA, Takaomi NOMURA, Ryoichi ARAI, Kimio HIRABAYASHI, Masuhiro TSUKADA, and Koji ABE


Domain-swapped dimeric structure of a stable and functional de novo 4-helix bundle protein, WA20
6th International Conference on Advanced Fiber/Textile Materials 2011 , :IP-12, p.18 2011
Author:Kobayashi, N., Kimura, A., Sato, T., Matsuo T., Wang, A. F., Platt, J., Bradley, L. H. Hecht, M. H. and Arai, R.,


Domain-swapped dimeric structure of a de novo 4-helix bundle protein, WA20
PDB40 Symposium (A Special Symposium Celebrating the 40th Anniversary of the Protein Data Bank) , :2 2011
Author:Arai, R., Kobayashi, N., Kimura, A., Sato, T., Wang, A. F., Platt, J., Bradley, L. H. and Hecht, M. H.


Crystal structure of a dimeric de novo 4-helix bundle protein WA20
IX European Symposium of The Protein Society , :13013, p.87 2011
Author:Arai, R., Kimura, A., Kobayashi, N., Sato, T., Wang, A. F., Platt, J., Bradley, L. H. and Hecht, M. H.


Crystal structure of MqnD, a menaquinone biosynthetic enzyme from Thermus thermophilus HB8
Gordon Research Conference, Biopolymers , :0 2010
Author:Arai, R., Murayama, K., Uchikubo-kamo, T., Nishimoto, M., Toyama, M., Kuramitsu, S., Terada, T., Shirouzu, M. and Yokoyama, S.


Protein Composition in Silk Grand of Caddisfly, Stenopsyche Marmorata, Larva.
14th International Symposium on River and Lake Environments , :Global-COE session: Biofiber of aquatic insects 2009
Author:K. Ohkawa, T. Nomura, R.Arai, K. Abe, M. Tsukada, K. Hirabayashi


A four-helix bundle de novo heme protein by phage display screening
7th East Asian Symposium on Polymers for Advanced Technologies (EASPAT 2009) , :PS04, p.68 2009
Author:R. Arai, M. H. Hecht


Crystal structure of MqnD (TTHA1568), a menaquinone biosynthetic enzyme from Thermus thermophilus HB8
21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology , :B-6-018, p.105 2009
Author:R. Arai, K. Murayama, T. Uchikubo-Kamo, M. Nishimoto, M. Toyama, S. Kuramitsu, T. Terada, M. Shirouzu, S. Yokoyama


Design and construction of functional artificial proteins: Phage display screening of four-helix bundle de novo proteins
4th International Conference on Advanced Fiber/Textile Materials 2007 in Ueda (ICAFTM2007) , :PA-18, p.73 2007
Author:R. Arai, M.H. Hecht


その他
人工蛋白質で「かたち」をつくろう―ブロック遊びしようよ!
生物工学会誌 , 94:270 2016
Author:小林直也,新井亮一


糖タンパク質の糖鎖修飾部位の網羅的同定方法
日本分析学会 , ぶんせき , (11):686 2003
Author:新井亮一 (トピックス解説)

研究費
科学研究費補助金(研究代表者)
2016 - 2018 , サーマルプログラミングによる蛋白質ナノブロックの逐次的自己組織化基盤技術の開発 , 基盤研究(C)
2016 - 2017 , 人工蛋白質ナノブロック自己組織化超分子複合体の構造機能解析と動的秩序系設計構築 , 新学術領域研究(生命分子システムにおける動的秩序形成と高次機能発現・公募研究)
2012 - 2015 , ピロリ菌型メナキノン生合成経路酵素群の立体構造解析及び反応機構解明 , 若手研究(B)
2012 - 2013 , 網羅的ペプチド相互作用実験データを用いた天然変性蛋白質の特性解析と親和性デザイン , 新学術領域研究(天然変性タンパク質の分子認識機構と機能発現・公募研究)
2010 - 2011 , パターンデザインペプチドライブラリーを用いた天然変性タンパク質の特性解析 , 新学術領域研究(天然変性タンパク質の分子認識機構と機能発現・公募研究)

科学研究費補助金(研究分担者)
2010 - 2012 , 細菌細胞表層制御による細胞増殖,形態,機能維持メカニズムの解明 , 基盤研究(A)
2010 - 2012 , アレルギー性疾患予防のためのトビケラ目大量飛来時期高精度予測手法の開発 , 基盤研究(C)
2010 - 2012 , 水生昆虫バイオシルクの特性解析、高機能化、医工学分野への応用 , 基盤研究(C)

奨学寄附金
2013 , 限定アミノ酸セットによる原始的人工ヘム蛋白質の創製及び分子進化工学,第13回リバネス研究費Direct Detect賞
2010 , 新規メナキノン生合成経路酵素の構造機能解析及び阻害剤探索, ホクト生物科学振興財団研究奨励金給付事業

その他
2008 - 2008 , 信州産ヒゲナガカワトビケラの絹糸に学ぶ新繊維材料の創出に向けて, 平成20年度信州大学若手研究者萌芽研究支援事業

教育活動実績

授業等
2013 , 前期 , 作文・プレゼンテーション演習
2013 , 前期 , フィールド科学実習(分担)
2013 , 前期 , 新入生ゼミナール(分担)
2013 , 前期 , 化学基礎実験I(分担)
2013 , 後期 , 生化学Ⅱ
2013 , 後期 , 資源生物利用学実験(分担)
2013 , 後期 , 情報科学・統計学演習(分担)
2012 , 前期 , 作文・プレゼンテーション演習
2012 , 前期 , フィールド科学実習(分担)
2012 , 前期 , 新入生ゼミナール(分担)
2012 , 後期 , 生化学Ⅱ
2012 , 後期 , 資源生物利用学実験(分担)
2011 , 前期 , 作文・プレゼンテーション演習
2011 , 前期 , フィールド科学実習(分担)
2011 , 後期 , 生化学Ⅱ
2011 , 後期 , 資源生物利用学実験(分担)
2010 , 前期 , 作文・プレゼンテーション演習
2010 , 前期 , フィールド科学実習(分担)
2010 , 後期 , 生化学Ⅱ
2010 , 後期 , 資源生物利用学実験(分担)
2009 , 後期 , 分子生物工学実験(分担)
2009 , 後期 , 生化学Ⅱ
2008 , 後期 , 分子生物学Ⅱ(分担)
2008 , 後期 , 分子生物工学実験(分担)
論文指導
2013
卒業論文指導 指導学生数 計:3
修士論文指導 指導学生数 計:2
博士論文指導 指導学生数 計:1

2012
卒業論文指導 指導学生数 計:2
修士論文指導 指導学生数 計:4
研究生指導 指導学生数 計:1

2011
卒業論文指導 指導学生数 計:2(内留学生:1)
修士論文指導 指導学生数 計:4

2010
卒業論文指導 指導学生数 計:2
修士論文指導 指導学生数 計:2

2009
卒業論文指導 指導学生数 計:2

2008
卒業論文指導 指導学生数 計:1

留学生受入
2013 , 前期人数:1 , 後期人数:1 , M2
2012 , 前期人数:1 , 後期人数:1 , M1
2011 , 前期人数:1 , 後期人数:1 , B4

管理運営実績

管理運営実績
学部内委員会等
2013 - , 学生委員会 , 委員
2012 - , 図書委員会 , 委員