田中 直樹 (タナカ ナオキ)
学術研究院（医学系）
医学部 医学科
教授
研究者情報
研究キーワード
- 非アルコール性脂肪性肝疾患・脂肪肝炎, NASH, NAFLD, 核内受容体、PPAR, メタボリックシンドローム, 脂肪細胞, 肝臓病学, 病態栄養, 肥満, 糖尿病
電話番号
- 0263-37-2354
メールアドレス
- naopi★shinshu-u.ac.jp
経歴
研究活動情報
受賞
- 2020年
第23回日本病態栄養学会年次学術集会 若手研究会長賞 - 2015年
米国国立衛生研究所, The Fellows Award for Research Excellence in NIH - 2014年
米国国立衛生研究所, The Fellows Award for Research Excellence in NIH - 2013年
米国国立衛生研究所, The Fellows Award for Research Excellence in NIH - 2010年
第23回日本消化器病学会奨励賞 - 2009年
信州大学医学部松医会賞基礎分野 - 2008年
日本肝臓学会第7回Schering-Plough Award基礎分野優秀賞 - 2007年
ウイルス肝炎研究財団 研究助成
論文
- 多機能性分子・硫酸化糖脂質の機能と制御
中嶌岳郎, 田中直樹
信州医学雑誌, 71(3), 137-147, 2023年06月
- 2-Step PLT16-AST44 method: Simplified liver fibrosis detection system in patients with non-alcoholic fatty liver disease
Fujimori, Naoyuki; Kimura, Takefumi; Tanaka, Naoki; Yamazaki, Tomoo; Okumura, Taiki; Kobayashi, Hiroyuki; Wakabayashi, Shun-Ichi; Yamashita, Yuki; Sugiura, Ayumi; Pham, Jonathan; Pydi, Sai P.; Sano, Kenji; Joshita, Satoru; Umemura, Takeji;
HEPATOLOGY RESEARCH, 52(4), 352-363, 2022年04月
- Serum Sulfatide Levels as a Biomarker of Active Glomerular Lesion in Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Single Center Pilot Study
Harada, Makoto; Nakajima, Takero; Yamada, Yosuke; Aomura, Daiki; Yamaguchi, Akinori; Sonoda, Kosuke; Tanaka, Naoki; Hashimoto, Koji; Kamijo, Yuji;
JOURNAL OF CLINICAL MEDICINE, 11(3), 762, 2022年02月 - Mucosal defect size predicts the adequacy of resection of <= 10 mm nonpedunculated colorectal polyps using a new cold snare polypectomy technique
Kudo, Takahiro; Horiuchi, Akira; Kyodo, Reiko; Tokita, Kazuhide; Tanaka, Naoki; Horiuchi, Ichitaro; Sano, Kenji;
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 33, E484-E489, 2021年12月 - Mechanisms of Steatosis-Derived Hepatocarcinogenesis: Lessons from HCV Core Gene Transgenic Mice
Diao, Pan; Jia, Fangping; Wang, Xiaojing; Hu, Xiao; Kimura, Takefumi; Nakajima, Takero; Aoyama, Toshifumi; Moriya, Kyoji; Koike, Kazuhiko; Tanaka, Naoki;
ENGINEERING, 7(12), 1797-1805, 2021年12月 - Impact of Dietary Fat on the Progression of Liver Fibrosis: Lessons from Animal and Cell Studies
Jia, Fangping; Hu, Xiao; Kimura, Takefumi; Tanaka, Naoki;
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(19), 10303, 2021年10月 - Pemafibrate Protects against Fatty Acid-Induced Nephropathy by Maintaining Renal Fatty Acid Metabolism
Aomura, Daiki; Harada, Makoto; Yamada, Yosuke; Nakajima, Takero; Hashimoto, Koji; Tanaka, Naoki; Kamijo, Yuji;
METABOLITES, 11(6), 372, 2021年06月 - Linked colour imaging versus white-light colonoscopy for the detection of flat colorectal lesions: A randomized controlled trial
Kudo, Takahiro; Horiuchi, Akira; Kyodo, Reiko; Horiuchi, Ichitaro; Arai, Nobuyasu; Kajiyama, Masashi; Tanaka, Naoki;
COLORECTAL DISEASE, 23(6), 1414-1420, 2021年06月 - Serum thrombospondin 2 is a novel predictor for the severity in the patients with NAFLD
Kimura, Takefumi; Tanaka, Naoki; Fujimori, Naoyuki; Yamazaki, Tomoo; Katsuyama, Takahito; Iwashita, Yuichi; Pham, Jonathan; Joshita, Satoru; Pydi, Sai P.; Umemura, Takeji;
LIVER INTERNATIONAL, 41(3), 505-514, 2021年03月, 査読有り - Role of G Protein-Coupled Receptors in Hepatic Stellate Cells and Approaches to Anti-Fibrotic Treatment of Non-Alcoholic Fatty Liver Disease
Kimura, Takefumi; Singh, Simran; Tanaka, Naoki; Umemura, Takeji;
FRONTIERS IN ENDOCRINOLOGY, 12, 773432, 2021年 - A saturated fatty acid-rich diet enhances hepatic lipogenesis and tumorigenesis in HCV core gene transgenic mice
Diao, Pan; Wang, Xiaojing; Jia, Fangping; Kimura, Takefumi; Hu, Xiao; Shirotori, Saki; Nakamura, Ibuki; Sato, Yoshiko; Nakayama, Jun; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Aoyama, Toshifumi; Tanaka, Naoki;
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 85, 2020年11月 - Invasive liver abscess syndrome accompanied by spondylodiscitis: a case report and review of the literature
Wakabayashi SI, Kimura T, Tanaka N, Pham J, Tanaka T, Higuchi S, Kobayashi J, Umemura T, Iijima A.
Clin J Gastroenterol, 13(5), 927-934, 2020年10月, 査読有り - Metabolic Functions of G Protein-Coupled Receptors in Hepatocytes-Potential Applications for Diabetes and NAFLD
Kimura, Takefumi; Pydi, Sai P.; Pham, Jonathan; Tanaka, Naoki;
BIOMOLECULES, 10(10), 2020年10月 - Non-alcoholic fatty liver disease later diagnosed as myotonic dystrophy
Tanaka N, Kimura T, Fujimori N, Ichise Y, Sano K, Horiuchi A.
World J Hepatol. 2020 Sep 27;12(9):685-692. doi: 10.4254/wjh.v12.i9.685., 12(9), 685-692, 2020年09月, 査読有り
筆頭著者, 責任著者 - Acute liver failure with severe steatosis induced by mushroom
Wakabayashi, Shun-ichi; Kimura, Takefumi; Tanaka, Naoki;
LIVER INTERNATIONAL, 40(9), 2291-2292, 2020年09月 - Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice
Jia, Fangping; Diao, Pan; Wang, Xiaojing; Hu, Xiao; Kimura, Takefumi; Nakamuta, Makoto; Nakamura, Ibuki; Shirotori, Saki; Sato, Yoshiko; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Nakayama, Jun; Aoyama, Toshifumi; Tanaka, Naoki;
Liver Cancer, 9(5), 529-548, 2020年09月 - Polyunsaturated fatty acid deficiency affects sulfatides and other sulfated glycans in lysosomes through autophagy-mediated degradation
Wang, Yaping; Nakajima, Takero; Diao, Pan; Yamada, Yosuke; Nakamura, Kozo; Nakayama, Jun; Tanaka, Naoki; Aoyama, Toshifumi; Kamijo, Yuji;
FASEB JOURNAL, 34(7), 9594-9614, 2020年07月 - Congestive hepatopathy and acute pancreatitis as severe complications of mixed connective tissue disease
Kurihara S, Kimura T, Tanaka N, Yanagisawa T, Kobayashi H, Kanai K, Umemura T, Kobayashi M, Mori H, Wada S.
Clin J Gastroenterol, 13(3), 434-442, 2020年06月, 査読有り - PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice
Wang, Yaping; Nakajima, Takero; Gonzalez, Frank J.; Tanaka, Naoki;
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(6), 2020年03月 - Long-term luseogliflozin therapy improves histological activity of non-alcoholic steatohepatitis accompanied by type 2 diabetes mellitus
Fujimori N, Tanaka N, Kimura T, Sano K, Horiuchi A, Kato N, Takahashi Y, Kuribayashi N, Sugiura A, Yamazaki T, Joshita S, Umemura T, Matsumoto A, Tanaka E.
Clin J Gastroenterol, 13(1), 83-89, 2020年02月, 査読有り
責任著者 - A trans-fatty acid-rich diet promotes liver tumorigenesis in HCV core gene transgenic mice
Hu, Xiao; Wang, Xiaojing; Jia, Fangping; Tanaka, Naoki; Kimura, Takefumi; Nakajima, Takero; Sato, Yoshiko; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Nakayama, Jun; Aoyama, Toshifumi;
CARCINOGENESIS, 41(2), 159-170, 2020年02月 - Cold snare polypectomy: Indications, devices, techniques, outcomes and future
Horiuchi, Akira; Ikuse, Tamaki; Tanaka, Naoki;
DIGESTIVE ENDOSCOPY, 31(4), 372-377, 2019年07月 - A high-cholesterol diet promotes steatohepatitis and liver tumorigenesis in HCV core gene transgenic mice
Wang, Xiaojing; Tanaka, Naoki; Hu, Xiao; Kimura, Takefumi; Lu, Yu; Jia, Fangping; Sato, Yoshiko; Nakayama, Jun; Moriya, Kyoji; Koike, Kazuhiko; Aoyama, Toshifumi;
ARCHIVES OF TOXICOLOGY, 93(6), 1713-1725, 2019年06月 - Safety and Effectiveness of Nurse-Administered Propofol Sedation in Outpatients Undergoing Gastrointestinal Endoscopy
Sato, Masamichi; Horiuchi, Akira; Tamaki, Michio; Ichise, Yasuyuki; Kajiyama, Masashi; Yamamoto, Yuta; Tanaka, Naoki;
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 17(6), 1098-+, 2019年05月 - Red plasma and ascites under ultraviolet A
Wakabayashi, Shun-ichi; Kimura, Takefumi; Tanaka, Naoki; Komatsu, Michiharu; Tanaka, Eiji;
LANCET GASTROENTEROLOGY & HEPATOLOGY, 4(4), 324-324, 2019年04月 - Peroxisome proliferator-activated receptor attenuates high-cholesterol diet-induced toxicity and pro-thrombotic effects in mice
Lu, Yu; Harada, Makoto; Kamijo, Yuji; Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Kyogashima, Mamoru; Gonzalez, Frank J.; Aoyama, Toshifumi;
ARCHIVES OF TOXICOLOGY, 93(1), 149-161, 2019年01月 - Gastric Emptying of Elemental Liquid Diets Versus Semisolid Diets in Bedridden Gastrostomy-fed Patients
Horiuchi, Akira; Sakai, Ryosei; Tamaki, Michio; Kajiyama, Masashi; Tanaka, Naoki; Morikawa, Akio;
JOURNAL OF CLINICAL GASTROENTEROLOGY, 53(5), 373-378, 2019年 - Current status, problems, and perspectives of non-alcoholic fatty liver disease research
Tanaka, Naoki; Kimura, Takefumi; Fujimori, Naoyuki; Nagaya, Tadanobu; Komatsu, Michiharu; Tanaka, Eiji;
WORLD JOURNAL OF GASTROENTEROLOGY, 25(2), 163-177, 2019年 - Miglitol attenuates non-alcoholic steatohepatitis in diabetic patients
Komatsu, Michiharu; Tanaka, Naoki; Kimura, Takefumi; Fujimori, Naoyuki; Sano, Kenji; Horiuchi, Akira; Sugiura, Ayumi; Yamazaki, Tomoo; Shibata, Soichiro; Joshita, Satoru; Umemura, Takeji; Matsumoto, Akihiro; Tanaka, Eiji;
HEPATOLOGY RESEARCH, 48(13), 1092-1098, 2018年12月 - Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development.
Takahashi S, Tanaka N, Fukami T, Xie C, Yagai T, Kim D, Velenosi TJ, Yan T, Krausz KW, Levi M, Gonzalez FJ.
Hepatol Commun, 2(12), 1567-1582, 2018年10月 - Emergence of anti-mitochondrial M2 antibody in patient with angioimmunoblastic T-cell lymphoma.
Wakabayashi SI, Kimura T, Tanaka N, Joshita S, Kawata K, Umemura T, Hiroshima Y, Mori H, Kobayashi H, Wada S, Tanaka E.
Clin J Gastroenterol, 11(4), 302-308, 2018年08月 - Delayed Bleeding Following Cold Snare Polypectomy for Small Colorectal Polyps in Patients Taking Antithrombotic Agents
Makino, Toshiyuki; Horiuchi, Akira; Kajiyama, Masashi; Tanaka, Naoki; Sano, Kenji; Maetani, Iruru;
JOURNAL OF CLINICAL GASTROENTEROLOGY, 52(6), 502-507, 2018年07月 - Salmonella Enteritidis cholecystitis with chronic granulomatous disease.
Yamashita Y, Kimura T, Tanaka N, Yazaki M, Itagaki T, Joshita S, Umemura T, Matsumoto A, Mori H, Wada S, Tanaka E.
IDCases, 12, 12:49-52, 2018年05月 - Mild drinking habit is a risk factor for hepatocarcinogenesis in non-alcoholic fatty liver disease with advanced fibrosis
Kimura, Takefumi; Tanaka, Naoki; Fujimori, Naoyuki; Sugiura, Ayumi; Yamazaki, Tomoo; Joshita, Satoru; Komatsu, Michiharu; Umemura, Takeji; Matsumoto, Akihiro; Tanaka, Eiji;
WORLD JOURNAL OF GASTROENTEROLOGY, 24(13), 1440-1450, 2018年04月 - Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non-alcoholic fatty liver disease
Fujimori, Naoyuki; Umemura, Takeji; Kimura, Takefumi; Tanaka, Naoki; Sugiura, Ayumi; Yamazaki, Tomoo; Joshita, Satoru; Komatsu, Michiharu; Usami, Yoko; Sano, Kenji; Igarashi, Koji; Matsumoto, Akihiro; Tanaka, Eiji;
WORLD JOURNAL OF GASTROENTEROLOGY, 24(11), 1239-1249, 2018年03月 - Hepatic Angiosarcoma with Kasabach-Merritt Phenomenon: A Case Report and Review of the Literature
Fujii, Fumika; Kimura, Takefumi; Tanaka, Naoki; Kubota, Daisuke; Sugiura, Ayumi; Umemura, Takeji; Wada, Shuichi; Tanaka, Eiji;
ANNALS OF HEPATOLOGY, 17(4), 655-660, 2018年 - Growth arrest and DNA damage-inducible 45 alpha protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet
Tanaka, Naoki; Takahashi, Shogo; Hu, Xiao; Lu, Yu; Fujimori, Naoyuki; Golla, Srujana; Fang, Zhong-Ze; Aoyama, Toshifumi; Krausz, Kristopher W.; Gonzalez, Frank J.;
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1863(12), 3170-3182, 2017年12月 - Targeting nuclear receptors for the treatment of fatty liver disease
Tanaka, Naoki; Aoyama, Toshifumi; Kimura, Shioko; Gonzalez, Frank J.;
PHARMACOLOGY & THERAPEUTICS, 179, 142-157, 2017年11月 - Association between lower air pressure and the onset of ischemic colitis: a case-control study
Kimura, Takefumi; Shinji, Akihiro; Tanaka, Naoki; Koinuma, Masayoshi; Yamaura, Maki; Nagaya, Tadanobu; Joshita, Satoru; Komatsu, Michiharu; Umemura, Takeji; Horiuchi, Akira; Wada, Shuichi; Tanaka, Eiji;
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 29(9), 1071-1078, 2017年09月 - Farnesoid X Receptor Protects Against Low-Dose Carbon Tetrachloride-Induced Liver Injury Through the Taurocholate-JNK Pathway
Takahashi, Shogo; Tanaka, Naoki; Golla, Srujana; Fukami, Tatsuki; Krausz, Kristopher W.; Polunas, Marianne A.; Weig, Blair C.; Masuo, Yusuke; Xie, Cen; Jiang, Changtao; Gonzalez, Frank J.;
Toxicological Sciences, 158(2), 334-346, 2017年08月 - Decreased Fatty Acid beta-Oxidation Is the Main Cause of Fatty Liver Induced by Polyunsaturated Fatty Acid Deficiency in Mice
Nakajima, Takero; Yang, Yang; Lu, Yu; Kamijo, Yuji; Yamada, Yosuke; Nakamura, Kozo; Koyama, Masahiro; Yamaguchi, Shohei; Sugiyama, Eiko; Tanaka, Naoki; Aoyama, Toshifumi;
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 242(3), 229-239, 2017年07月 - Role of the lipid-regulated NF-kappa B/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury
Fang, Zhong-Ze; Tanaka, Naoki; Lu, Dan; Jiang, Chang-Tao; Zhang, Wei-Hua; Zhang, Chunze; Du, Zuo; Fu, Zhi-Wei; Gao, Peng; Cao, Yun-Feng; Sun, Hong-Zhi; Zhu, Zhi-Tu; Cai, Yan; Krausz, Kristopher W.; Yao, Zhi; Gonzalez, Frank J.;
ARCHIVES OF TOXICOLOGY, 91(5), 2235-2244, 2017年05月 - Clinicopathological characteristics of non-B non-C hepatocellular carcinoma without past hepatitis B virus infection
Kimura, Takefumi; Kobayashi, Akira; Tanaka, Naoki; Sano, Kenji; Komatsu, Michiharu; Fujimori, Naoyuki; Yamazaki, Tomoo; Shibata, Soichiro; Ichikawa, Yuki; Joshita, Satoru; Umemura, Takeji; Matsumoto, Akihiro; Horiuchi, Akira; Mori, Hiromitsu; Wada, Shuichi; Kiyosawa, Kendo; Miyagawa, Shin-ichi; Tanaka, Eiji;
HEPATOLOGY RESEARCH, 47(5), 405-418, 2017年04月 - PPAR alpha protects against trans-fatty-acid-containing diet-induced steatohepatitis
Hu, Xiao; Tanaka, Naoki; Guo, Ran; Lu, Yu; Nakajima, Takero; Gonzalez, Frank J.; Aoyama, Toshifumi;
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 39, 77-85, 2017年01月 - Association between endotoxemia and histological features of nonalcoholic fatty liver disease
Kitabatake, Hiroyuki; Tanaka, Naoki; Fujimori, Naoyuki; Komatsu, Michiharu; Okubo, Ayaka; Kakegawa, Kyogo; Kimura, Takefumi; Sugiura, Ayumi; Yamazaki, Tomoo; Shibata, Soichiro; Ichikawa, Yuki; Joshita, Satoru; Umemura, Takeji; Matsumoto, Akihiro; Koinuma, Masayoshi; Sano, Kenji; Aoyama, Toshifumi; Tanaka, Eiji;
WORLD JOURNAL OF GASTROENTEROLOGY, 23(4), 712-722, 2017年 - Vonoprazan-Based Regimen Is More Useful than PPI-Based One as a First-Line Helicobacter pylori Eradication: A Randomized Controlled Trial
Maruyama, Masafumi; Tanaka, Naoki; Kubota, Daisuke; Miyajima, Masayuki; Kimura, Takefumi; Tokutake, Koujiro; Imai, Ryujiro; Fujisawa, Toru; Mori, Hiromitsu; Matsuda, Yoshiaki; Wada, Shuichi; Horiuchi, Akira; Kiyosawa, Kendo;
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2017年 - Glycyrrhizin and glycyrrhetinic acid inhibits alpha-naphthyl isothiocyanate-induced liver injury and bile acid cycle disruption
Wang, Haina; Fang, Zhong-Ze; Meng, Ran; Cao, Yun-Feng; Tanaka, Naoki; Krausz, Kristopher W.; Gonzalez, Frank J.;
Toxicology, 386, 133-142, 2017年 - Age-dependent PPAR alpha activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene
Tian, Yangyang; Yang, Yang; Zhang, Xiaowei; Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Kamijo, Yuji; Lu, Yu; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Aoyama, Toshifumi;
GLYCOCONJUGATE JOURNAL, 33(6), 927-936, 2016年12月 - PPAR alpha-dependent cholesterol/testosterone disruption in Leydig cells mediates 2,4-dichlorophenoxyacetic acid-induced testicular toxicity in mice
Harada, Yukiko; Tanaka, Naoki; Ichikawa, Motoki; Kamijo, Yuji; Sugiyama, Eiko; Gonzalez, Frank J.; Aoyama, Toshifumi;
ARCHIVES OF TOXICOLOGY, 90(12), 3061-3071, 2016年12月 - Activation of PPAR alpha by Fatty Acid Accumulation Enhances Fatty Acid Degradation and Sulfatide Synthesis
Yang, Yang; Feng, Yuyao; Zhang, Xiaowei; Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Kamijo, Yuji; Aoyama, Toshifumi;
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 240(2), 113-122, 2016年10月 - Controlled attenuation parameter is correlated with actual hepatic fat content in patients with non-alcoholic fatty liver disease with none-to-mild obesity and liver fibrosis
Fujimori, Naoyuki; Tanaka, Naoki; Shibata, Soichiro; Sano, Kenji; Yamazaki, Tomoo; Sekiguchi, Tomohiro; Kitabatake, Hiroyuki; Ichikawa, Yuki; Kimura, Takefumi; Komatsu, Michiharu; Umemura, Takeji; Matsumoto, Akihiro; Tanaka, Eiji;
HEPATOLOGY RESEARCH, 46(10), 1019-1027, 2016年09月 - Comparison between endoscopic mucosal resection and hot snare resection of large nonpedunculated colorectal polyps: a randomized trial
Horiuchi, Akira; Makino, Toshiyuki; Kajiyama, Masashi; Tanaka, Naoki; Sano, Kenji; Graham, David Y.;
ENDOSCOPY, 48(7), 646-651, 2016年07月 - Irinotecan (CPT-11)-induced elevation of bile acids potentiates suppression of IL-10 expression
Fang, Zhong-Ze; Zhang, Dunfang; Cao, Yun-Feng; Xie, Cen; Lu, Dan; Sun, Dong-Xue; Tanaka, Naoki; Jiang, Changtao; Chen, Qianming; Chen, Yu; Wang, Haina; Gonzalez, Frank J.;
Toxicology and Applied Pharmacology, 291, 21-27, 2016年 - Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans
Xu, Ming-Jiang; Cai, Yan; Wang, Hua; Altamirano, Jose; Chang, Binxia; Bertola, Adeline; Odena, Gemma; Lu, Jim; Tanaka, Naoki; Matsusue, Kimihiko; Matsubara, Tsutomu; Mukhopadhyay, Partha; Kimura, Shioko; Pacher, Pal; Gonzalez, Frank J.; Bataller, Ramon; Gao, Bin;
GASTROENTEROLOGY, 149(4), 1030-U367, 2015年10月 - Prospective, randomized comparison of 2 methods of cold snare polypectomy for small colorectal polyps
Horiuchi, Akira; Hosoi, Kenji; Kajiyama, Masashi; Tanaka, Naoki; Sano, Kenji; Graham, David Y.;
GASTROINTESTINAL ENDOSCOPY, 82(4), 686-692, 2015年10月 - St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling
Manna, Soumen K.; Golla, Srujana; Golla, Jaya Prakash; Tanaka, Naoki; Cai, Yan; Takahashi, Shogo; Krausz, Kristopher W.; Matsubara, Tsutomu; Korboukh, Ilia; Gonzalez, Frank J.;
CANCER PREVENTION RESEARCH, 8(9), 786-795, 2015年09月 - Primary hepatocellular carcinoma in a patient with neurofibromatosis type I
Kimura, Takefumi; Tanaka, Naoki; Umemura, Takeji; Tanaka, Eiji;
LIVER INTERNATIONAL, 35(8), 2057-2058, 2015年08月 - Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet
Tanaka, Naoki; Takahashi, Shogo; Zhang, Yuan; Krausz, Kristopher W.; Smith, Philip B.; Patterson, Andrew D.; Gonzalez, Frank J.;
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1852(7), 1242-1252, 2015年07月 - Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation
Zhang, Limin; Nichols, Robert G.; Correll, Jared; Murray, Iain A.; Tanaka, Naoki; Smith, Philip B.; Hubbard, Troy D.; Sebastian, Aswathy; Albert, Istvan; Hatzakis, Emmanuel; Gonzalez, Frank J.; Perdew, Gary H.; Patterson, Andrew D.;
ENVIRONMENTAL HEALTH PERSPECTIVES, 123(7), 679-688, 2015年07月 - Steatogenesis in adult-onset type II citrullinemia is associated with down-regulation of PPAR alpha
Komatsu, Michiharu; Kimura, Takefumi; Yazaki, Masahide; Tanaka, Naoki; Yang, Yang; Nakajima, Takero; Horiuchi, Akira; Fang, Zhong-Ze; Joshita, Satoru; Matsumoto, Akihiro; Umemura, Takeji; Tanaka, Eiji; Gonzalez, Frank J.; Ikeda, Shu-Ichi; Aoyama, Toshifumi;
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1852(3), 473-481, 2015年03月 - Comparison of newly found polyps after removal of small colorectal polyps with cold or hot snare polypectomy
Horiuchi, Akira; Makino, Toshiyuki; Ichise, Yasuyuki; Kajiyama, Masashi; Kato, Naoyuki; Tanaka, Naoki;
ACTA GASTRO-ENTEROLOGICA BELGICA, 78(4), 406-410, 2015年 - Metabolic mapping of A(3) adenosine receptor agonist MRS5980
Fang, Zhong-Ze; Tosh, Dilip K.; Tanaka, Naoki; Wang, Haina; Krausz, Kristopher W.; O'Connor, Robert; Jacobson, Kenneth A.; Gonzalez, Frank J.;
Biochemical Pharmacology, 97(2), 215-223, 2015年 - Adipocyte-specific Disruption of Fat-specific Protein 27 Causes Hepatosteatosis and Insulin Resistance in High-fat Diet-fed Mice
Tanaka, Naoki; Takahashi, Shogo; Matsubara, Tsutomu; Jiang, Changtao; Sakamoto, Wataru; Chanturiya, Tatyana; Teng, Ruifeng; Gavrilova, Oksana; Gonzalez, Frank J.;
JOURNAL OF BIOLOGICAL CHEMISTRY, 290(5), 3092-3105, 2015年 - Helicobacter pylori-negative Differentiated Adenocarcinoma of the Stomach
Nagaya, Tadanobu; Tanaka, Naoki; Iwaya, Yugo; Jimbo, Yoko; Tatai, Toshiharu; Ito, Tetsuya; Seki, Ayako; Suzawa, Kenichi; Ochi, Yasuhide; Hara, Etsuo; Takata, Manabu; Otsuki, Toshiaki; Iwaya, Mai; Hosaka, Noriko; Arakura, Norikazu; Tanaka, Eiji; Hasebe, Osamu;
INTERNAL MEDICINE, 54(22), 2857-2862, 2015年 - Activation of Intestinal Human Pregnane X Receptor Protects against Azoxymethane/Dextran Sulfate Sodium-Induced Colon Cancer
Cheng, Jie; Fang, Zhong-Ze; Nagaoka, Kenjiro; Okamoto, Minoru; Qu, Aijuan; Tanaka, Naoki; Kimura, Shioko; Gonzalez, Frank J.;
Journal of Pharmacology and Experimental Therapeutics, 351(3), 559-567, 2014年12月 - Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet
Tanaka, Naoki; Takahashi, Shogo; Fang, Zhong-Ze; Matsubara, Tsutomu; Krausz, Kristopher W.; Qu, Aijuan; Gonzalez, Frank J.;
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1841(11), 1596-1607, 2014年11月 - Biliary stenting as alternative therapy to stone clearance in elderly patients with bile duct stones
Horiuchi, Akira; Kajiyama, Masashi; Ichise, Yasuyuki; Tada, Haruyo; Fujiwara, Naoyuki; Tanaka, Naoki;
ACTA GASTRO-ENTEROLOGICA BELGICA, 77(3), 297-301, 2014年09月 - Laparoscopic findings of congenital hepatic fibrosis: A case report and review of the published work
Komatsu, Michiharu; Tanaka, Naoki; Shibata, So-Ichirou; Kimura, Takefumi; Ichikawa, Yuki; Morita, Susumu; Joshita, Satoru; Nagaya, Tadanobu; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Tanaka, Eiji;
HEPATOLOGY RESEARCH, 44(7), 818-824, 2014年07月 - Biomarkers of Coordinate Metabolic Reprogramming in Colorectal Tumors in Mice and Humans
Manna, Soumen K.; Tanaka, Naoki; Krausz, Kristopher W.; Haznadar, Majda; Xue, Xiang; Matsubara, Tsutomu; Bowman, Elise D.; Fearon, Eric R.; Harris, Curtis C.; Shah, Yatrik M.; Gonzalez, Frank J.;
GASTROENTEROLOGY, 146(5), 1313-1324, 2014年05月 - In vivo effects of the pure aryl hydrocarbon receptor antagonist GNF-351 after oral administration are limited to the gastrointestinal tract
Fang, Zhong-Ze; Krausz, Kristopher W.; Nagaoka, Kenjiro; Tanaka, Naoki; Gowda, Krishne; Amin, Shantu G.; Perdew, Gary H.; Gonzalez, Frank J.;
British Journal of Pharmacology, 171(7), 1735-1746, 2014年04月 - Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice
Cheng, Jie; Fang, Zhong-Ze; Kim, Jung-Hwan; Krausz, Kristopher W.; Tanaka, Naoki; Chiang, John Y. L.; Gonzalez, Frank J.;
Journal of Lipid Research, 55(3), 455-465, 2014年03月 - Removal of small colorectal polyps in anticoagulated patients: a prospective randomized comparison of cold snare and conventional polypectomy
Horiuchi, Akira; Nakayama, Yoshiko; Kajiyama, Masashi; Tanaka, Naoki; Sano, Kenji; Graham, David Y.;
GASTROINTESTINAL ENDOSCOPY, 79(3), 417-423, 2014年03月 - Role of Myc in hepatocellular proliferation and hepatocarcinogenesis
Qu, Aijuan; Jiang, Changtao; Cai, Yan; Kim, Jung-Hwan; Tanaka, Naoki; Ward, Jerrold M.; Shah, Yatrik M.; Gonzalez, Frank J.;
JOURNAL OF HEPATOLOGY, 60(2), 331-338, 2014年02月 - Chronic ethanol consumption decreases serum sulfatide levels by suppressing hepatic cerebroside sulfotransferase expression in mice
Kanbe, Hiroki; Kamijo, Yuji; Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Wang, Lixuan; Fang, Zhong-Ze; Hara, Atsushi; Gonzalez, Frank J.; Aoyama, Toshifumi;
ARCHIVES OF TOXICOLOGY, 88(2), 367-379, 2014年02月 - Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-kappa B and STAT3 signaling
Liu, Aiming; Tanaka, Naoki; Sun, Lu; Guo, Bin; Kim, Jung-Hwan; Krausz, Kristopher W.; Fang, Zhongze; Jiang, Changtao; Yang, Julin; Gonzalez, Frank J.;
CHEMICO-BIOLOGICAL INTERACTIONS, 223, 80-86, 2014年 - Improving quality measures in colonoscopy and its therapeutic intervention
Horiuchi, Akira; Tanaka, Naoki;
WORLD JOURNAL OF GASTROENTEROLOGY, 20(36), 13027-13034, 2014年 - PPAR alpha-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate
Qi, Yunpeng; Jiang, Changtao; Tanaka, Naoki; Krausz, Kristopher W.; Brocker, Chad N.; Fang, Zhong-Ze; Bredell, Bryce X.; Shah, Yatrik M.; Gonzalez, Frank J.;
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 307(5), G564-G573, 2014年 - Herb-drug interaction prediction based on the high specific inhibition of andrographolide derivatives towards UDP-glucuronosyltransferase (UGT) 2B7
Ma, Hai-Ying; Sun, Dong-Xue; Cao, Yun-Feng; Ai, Chun-Zhi; Qu, Yan-Qing; Hu, Cui-Min; Jiang, Changtao; Dong, Pei-Pei; Sun, Xiao-Yu; Hong, Mo; Tanaka, Naoki; Gonzalez, Frank J.; Ma, Xiao-Chi; Fang, Zhong-Ze;
Toxicology and Applied Pharmacology, 277(1), 86-94, 2014年 - A model of in vitro UDP-glucuronosyltransferase inhibition by bile acids predicts possible metabolic disorders
Fang, Zhong-Ze; He, Rong-Rong; Cao, Yun-Feng; Tanaka, Naoki; Jiang, Changtao; Krausz, Kristopher W.; Qi, Yunpeng; Dong, Pei-Pei; Ai, Chun-Zhi; Sun, Xiao-Yu; Hong, Mo; Ge, Guang-Bo; Gonzalez, Frank J.; Ma, Xiao-Chi; Sun, Hong-Zhi;
Journal of Lipid Research, 54(12), 3334-3344, 2013年12月 - Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum
Fang, Zhong-Ze; Krausz, Kristopher W.; Tanaka, Naoki; Li, Fei; Qu, Aijuan; Idle, Jeffrey R.; Gonzalez, Frank J.
ARCHIVES OF TOXICOLOGY, 87(11), 1975-1987, 2013年11月 - Peroxisome proliferator-activated receptor alpha mediates enhancement of gene expression of cerebroside sulfotransferase in several murine organs
Nakajima, Takero; Kamijo, Yuji; Huang Yuzhe; Kimura, Takefumi; Tanaka, Naoki; Sugiyama, Eiko; Nakamura, Kozo; Kyogashima, Mamoru; Hara, Atsushi; Aoyama, Toshifumi;
GLYCOCONJUGATE JOURNAL, 30(6), 553-560, 2013年08月 - Safety and Effectiveness of Low-Dose Propofol Sedation During and After Esophagogastroduodenoscopy in Child A and B Cirrhotic Patients
Tanaka, Naoki; Horiuchi, Akira; Nakayama, Yoshiko; Katsuyama, Yoshihiko; Isobe, Masatsugu; Aoyama, Toshifumi; Tanaka, Eiji; Ohmori, Shigeru
DIGESTIVE DISEASES AND SCIENCES, 58(5), 1383-1389, 2013年05月 - TGF-beta-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury
Matsubara, Tsutomu; Tanaka, Naoki; Sato, Misako; Kang, Dong Wook; Krausz, Kristopher W.; Flanders, Kathleen C.; Ikeda, Kazuo; Luecke, Hans; Wakefield, Lalage M.; Gonzalez, Frank J.
Journal of Lipid Research, 53(12), 2698-2707, 2012年12月 - Metabolomics Identifies an Inflammatory Cascade Involved in Dioxin- and Diet-Induced Steatohepatitis
Matsubara, Tsutomu; Tanaka, Naoki; Krausz, Kristopher W.; Manna, Soumen K.; Kang, Dong Wook; Anderson, Erik R.; Luecke, Hans; Patterson, Andrew D.; Shah, Yatrik M.; Gonzalez, Frank J.
Cell Metabolism, 16(5), 634-644, 2012年11月07日 - Metabolomics reveals an essential role for peroxisome proliferator-activated receptor alpha in bile acid homeostasis
Li, Fei; Patterson, Andrew D.; Krausz, Kristopher W.; Tanaka, Naoki; Gonzalez, Frank J.
Journal of Lipid Research, 53(8), 1625-1635, 2012年08月 - Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis
Tanaka, Naoki; Matsubara, Tsutomu; Krausz, Kristopher W.; Patterson, Andrew D.; Gonzalez, Frank J.
Hepatology, 56(1), 118-129, 2012年07月 - Clinical characteristics of young-onset ischemic colitis
Kimura, Takefumi; Shinji, Akihiro; Horiuchi, Akira; Tanaka, Naoki; Nagaya, Tadanobu; Shigeno, Takashi; Nakamura, Naoshi; Komatsu, Michiharu; Umemura, Takeji; Arakura, Norikazu; Matsumoto, Akihiro; Tanaka, Eiji
DIGESTIVE DISEASES AND SCIENCES, 57(6), 1652-1659, 2012年06月 - PPAR alpha is down-regulated following liver transplantation in mice
Nakagawa, Kan; Tanaka, Naoki; Morita, Miwa; Sugioka, Atsushi; Miyagawa, Shin-ichi; Gonzalez, Frank J.; Aoyama, Toshifumi
JOURNAL OF HEPATOLOGY, 56(3), 586-594, 2012年03月 - Clinical characteristics of de novo nonalcoholic fatty liver disease following pancreaticoduodenectomy
Tanaka, Naoki; Horiuchi, Akira;Yokoyama, Takahide; Kaneko, Gengo; Horigome, Naoto; Yamaura, Takahiro; Nagaya, Tadanobu; Komatsu, Michiharu; Sano, Kenji; Miyagawa, Shin-ichi; Aoyama, Toshifumi; Tanaka, Eiji
JOURNAL OF GASTROENTEROLOGY, 46(6), 758-768, 2011年06月 - Lithocholic Acid Disrupts Phospholipid and Sphingolipid Homeostasis Leading to Cholestasis in Mice
Matsubara, Tsutomu; Tanaka, Naoki; Patterson, Andrew D.; Cho, Joo-Youn; Krausz, Kristopher W.; Gonzalez, Frank J.
Hepatology, 53(4), 1282-1293, 2011年04月 - Accurate and simple method for quantification of hepatic fat content using magnetic resonance imaging: a prospective study in biopsy-proven nonalcoholic fatty liver disease
Hatta, Tomoko; Fujinaga, Yasunari; Kadoya, Masumi; Ueda, Hitoshi; Murayama, Hiroaki; Kurozumi, Masahiro; Ueda, Kazuhiko; Komatsu, Michiharu; Nagaya, Tadanobu; Joshita, Satoru; Kodama, Ryo; Tanaka, Eiji; Uehara, Tsuyoshi; Sano, Kenji; Tanaka, Naoki
JOURNAL OF GASTROENTEROLOGY, 45(12), 1263-1271, 2010年12月 - Eicosapentaenoic acid improves hepatic steatosis independent of PPAR alpha activation through inhibition of SREBP-1 maturation in mice
Tanaka, Naoki; Zhang, Xiuguo; Sugiyama, Eiko; Kono, Hiroyuki; Horiuchi, Akira; Nakajima, Takero; Kanbe, Hiroki; Tanaka, Eiji; Gonzalez, Frank J.; Aoyama, Toshifumi
Biochemical Pharmacology, 80(10), 1601-1612, 2010年11月15日 - Down-regulation of SREBP-1c is associated with the development of burned-out NASH
Nagaya, Tadanobu; Tanaka, Naoki; Suzuki, Takefumi; Sano, Kenji; Horiuchi, Akira; Komatsu, Michiharu; Nakajima, Takero; Nishizawa, Tomoko; Joshita, Satoru; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Nakayama, Jun; Tanaka, Eiji; Aoyama, Toshifumi
JOURNAL OF HEPATOLOGY, 53(4), 724-731, 2010年10月 - Serum Fragmented Cytokeratin 18 Levels Reflect the Histologic Activity Score of Nonalcoholic Fatty Liver Disease More Accurately Than Serum Alanine Aminotransferase Levels
Tsutsui, Masaru; Tanaka, Naoki; Kawakubo, Masatomo; Sheena, Yo; Horiuchi, Akira; Komatsu, Michiharu; Nagaya, Tadanobu; Joshita, Satoru; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Aoyama, Toshifumi; Tanaka, Eiji; Sano, Kenji
JOURNAL OF CLINICAL GASTROENTEROLOGY, 44(6), 440-447, 2010年07月 - Nonalcoholic fatty liver disease in Japanese junior high school students: its prevalence and relationship to lifestyle habits
Tsuruta, Goro; Tanaka, Naoki; Hongo, Minoru; Komatsu, Michiharu; Horiuchi, Akira; Hamamoto, Kaeko; Iguchi, Chieko; Nakayama, Yoshiko; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Aoyama, Toshifumi; Tanaka, Eiji
JOURNAL OF GASTROENTEROLOGY, 45(6), 666-672, 2010年06月 - 一般中学生の高尿酸血症と生活習慣病との関連
本郷 実,日高 宏哉,阪口 しげ子,市川 元基,池田 宇一,田中 直樹,鶴田 悟郎,小池 健一
痛風と核酸代謝 = Gout and nucleic acid metabolism, 33(1), 17-26, 2009年07月01日 - Polyenephosphatidylcholine prevents alcoholic liver disease in PPAR alpha-null mice through attenuation of increases in oxidative stress
Okiyama, Wataru; Tanaka, Naoki; Nakajima, Tamie; Tanaka, Eiji; Kiyosawa, Kendo; Gonzalez, Frank J.; Aoyama, Toshifumi
JOURNAL OF HEPATOLOGY, 50(6), 1236-1246, 2009年06月 - Efficacy and safety of addition of minor bloodletting (petit phlebotomy) in hepatitis C virus-infected patients receiving regular glycyrrhizin injections
Tanaka, Naoki; Horiuchi, Akira; Yamaura, Takahiro; Komatsu, Michiharu; Yokoyama, Takahide; Okaniwa, Shinji; Nagaya, Tadanobu; Yoshizawa, Kaname; Kiyosawa, Kendo; Aoyama, Toshifumi; Tanaka, Eiji
JOURNAL OF GASTROENTEROLOGY, 44(6), 577-582, 2009年06月 - Bezafibrate at Clinically Relevant Doses Decreases Serum/Liver Triglycerides via Down-Regulation of Sterol Regulatory Element-Binding Protein-1c in Mice: A Novel Peroxisome Proliferator-Activated Receptor alpha-Independent Mechanism
Nakajima, Takero; Tanaka, Naoki; Kanbe, Hiroki; Hara, Atsushi; Kamijo, Yuji; Zhang, Xiaowei; Gonzalez, Frank J.; Aoyama, Toshifumi
MOLECULAR PHARMACOLOGY, 75(4), 782-792, 2009年04月 - Hepatitis C Virus, Splenic Vein Thrombosis, and Lymphoma
Tanaka, Naoki; Yokoyama, Takahide; Horiuchi, Akira
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 7(2), XXIV-XXIV, 2009年02月 - 広範囲の肝実質の脱落により奇異な肝形態を呈し自己免疫性肝炎が疑われた1例
城下 智,一條 哲也,吉澤 要,福島 万奈,小松 通治,新井 薫,田中 直樹,梅村 武司,松本 晶博,田中 榮司
日本消化器内視鏡学会雑誌 = Gastroenterological endoscopy, 51(1), 48-54, 2009年01月20日 - α型ペルオキシソーム増殖剤活性化受容体（PPARα）： 脂肪肝疾患との関連
田中直樹,青山俊文
信州医学雑誌, 56(6), 347-358, 2008年12月 - Citrin deficiency as a cause of chronic liver disorder mimicking non-alcoholic fatty liver disease
Komatsu, Michiharu; Yazaki, Masahide; Tanaka, Naoki; Sano, Kenji; Hashimoto, Etsuko; Taker, Yo-ichi; Song, Yuan-Zong; Tanaka, Eiji; Kiyosawa, Kendo; Saheki, Takeyori; Aoyama, Toshifumi; Kobayashi, Keiko
JOURNAL OF HEPATOLOGY, 49(5), 810-820, 2008年11月 - Insulin resistance and hepatitis C virus: a case-control study of non-obese, non-alcoholic and non-steatotic hepatitis virus carriers with persistently normal serumaminotransferase
Tanaka, Naoki; Nagaya, Tadanobu; Komatsu, Michiharu; Horiuchi, Akira; Tsuruta, Goro; Shirakawa, Haruaki; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Aoyama, Toshifumi; Kiyosawa, Kendo; Tanaka, Eiji
LIVER INTERNATIONAL, 28(8), 1104-1111, 2008年09月 - Cholesterol-lowering effectof bezafibrate is independent of peroxisome proliferator-activated receptor activation in mice
Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Kamijo, Yuji; Hara, Atsushi; Hu, Rui; Li, Gang; Li, Yufeng; Nakamura, Kozo; Gonzalez, Frank J.; Aoyama, Toshifumi
Biochemical Pharmacology, 76(1), 108-119, 2008年07月01日 - Highly purified eicosapentaenoic acid treatment improves nonalcoholic steatohepatitis
Tanaka, Naoki; Sano, Kenji; Horiuchi, Akira; Tanaka, Eiji; Kiyosawa, Kendo; Aoyama, Toshifumi
JOURNAL OF CLINICAL GASTROENTEROLOGY, 42(4), 413-418, 2008年04月 - PPAR alpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice
Tanaka, Naoki; Moriya, Kyoji; Kiyosawa, Kendo; Koike, Kazuhiko; Gonzalez, Frank J.; Aoyama, Toshifurni
JOURNAL OF CLINICAL INVESTIGATION, 118(2), 683-694, 2008年02月 - Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: Implications for HCV-associated hepatocarcinogenesis
Tanaka, Naoki; Moriya, Kyoji; Kiyosawa, Kendo; Koike, Kazuhiko; Aoyama, Toshifumi
INTERNATIONAL JOURNAL OF CANCER, 122(1), 124-131, 2008年01月01日 - Pancreatic exocrine insufficiency: A rare cause of nonalcoholic steatohepatitis
Tanaka, Naoki; Horiuchi, Akira; Yokoyama, Takahide; Kawa, Shigeyuki; Kiyosawa, Kendo
AMERICAN JOURNAL OF GASTROENTEROLOGY, 103(1), 245-246, 2008年01月 - 腹壁への浸潤が疑われ, 画像検査が診断の契機となった肝放線菌症の1例
武藤 英知,一條 哲也,小林 倫子,田中 直樹,梅村 武司,小松 通治,松本 晶博,吉澤 要,田中 榮司,上田 和彦,角谷 眞澄,清澤 研道
肝臓 = ACTA HEPATOLOGICA JAPONICA, 48(11), 553-558, 2007年11月25日 - A lean man with nonalcoholic fatty liver disease
Tanaka, Naoki; Yazaki, Masahide; Kobayashi, Keiko
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 5(3), XXXII-XXXII, 2007年03月 - Efficacy and safety of 6-month iron reduction therapy in patients with hepatitis C virus-related cirrhosis: a pilot study
Tanaka, Naoki; Horiuchi, Akira; Yamaura, Takahiro; Komatsu, Michiharu; Tanaka, Eiji; Kiyosawa, Kendo
JOURNAL OF GASTROENTEROLOGY, 42(1), 49-55, 2007年01月 - Useful parameters for distinguishing nonalcoholic steatohepatitis with mild steatosis from cryptogenic chronic hepatitis in the Japanese population
Tanaka, Naoki; Tanaka, Eiji; Sheena, Yo;Komatsu, Michiharu; Okiyama, Wataru; Misawa, Noriko; Muto, Hidetomo; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Horiuchi, Akira; Kiyosawa, Kendo
LIVER INTERNATIONAL, 26(8), 956-963, 2006年10月 - Peroxisome proliferator-activated receptor alpha-independent peroxisome proliferation
Zhang, Xiuguo; Tanaka, Naoki; Nakajuna, Takero; Kamijo, Yuji; Gonzalez, Frank J.; Aoyama, Toshifumi
Biochemical and biophysical research communications, 346(4), 1307-1311, 2006年08月11日 - Laparoscopic findings in patients with nonalcoholic steatohepatitis
Tanaka, N; Ichijo, T; Okiyama, W; Mutou, H; Misawa, N; Matsumoto, A; Yoshizawa, K; Tanaka, E; Kiyosawa, K
LIVER INTERNATIONAL, 26(1), 32-38, 2006年02月 - Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage
Nakajima, T; Kamijo, Y; Tanaka, N; Sugiyama, E; Tanaka, E; Kiyosawa, K; Fukushima, Y; Peters, JM; Gonzalez, FJ; Aoyama, T
Hepatology, 40(4), 972-980, 2004年10月 - Phlebotomy: a promising treatment for chronic hepatitis C
Tanaka, N; Kiyosawa, K
JOURNAL OF GASTROENTEROLOGY, 39(6), 601-603, 2004年06月 - Ribavirin-induced pure red-cell aplasia during treatment of chronic hepatitis C.
Tanaka, N; Ishida, F; Tanaka, E
NEW ENGLAND JOURNAL OF MEDICINE, 350(12), 1264-1265, 2004年03月18日 - In vivo stabilization of nuclear retinoid X receptor alpha in the presence of peroxisome proliferator-activated receptor alpha
Tanaka,N; Hora, K; Makishima, H; Kamijo, Y; Kiyosawa, K; Gonzalez, FJ; Aoyama, T
FEBS Letters, 543(1-3), 120-124, 2003年05月22日 - Development of hepatocellular carcinoma after longterm sustained complete response to interferon therapy: what is the mechanism?
Tanaka, N; Kiyosawa, K
JOURNAL OF GASTROENTEROLOGY, 38(4), 417-419, 2003年04月 - 非アルコール性脂肪性肝炎
田中 直樹,清澤 研道
肝臓, 43(12), 539-549, 2002年12月25日 - 非アルコール性脂肪肝炎の発症機構とPPAR
田中 直樹,青山 俊文
日本消化器病學會雜誌 = The Japanese journal of gastro-enterology, 99(6), 563-569, 2002年06月05日 - トピックス 4.Peroxisome proliferator-activated receptor(PPAR)
田中 直樹,青山 俊文
日本内科学会雑誌, 90(10), 2033-2039, 2001年10月10日 - Initiation of enzyme replacement therapy for an adult patient with asymptomatic type 1 Gaucher's disease
Tanaka, N; Saito, H; Ito, T; Momose, K; Ishida, F; Hora, K; Kiyosawa, K; Ida, H
INTERNAL MEDICINE, 40(8), 716-721, 2001年08月 - Back pain out of the blue in a haemodialysis patient
Tanaka, N; Kasahara, H; Yoshie, T; Hora, K; Kiyosawa, K
NEPHROLOGY DIALYSIS TRANSPLANTATION, 14(7), 1792-1794, 1999年07月
担当経験のある科目_授業
共同研究・競争的資金等の研究課題
- 食事中トランス脂肪酸による肝発癌促進機能の解明と予防法の開発
科学研究費補助金, 基盤研究（Ｃ）
2019年 - 2021年 - 生体異物代謝を機軸とした非アルコール性脂肪肝炎発症機構の解明
科学研究費補助金, 基盤研究（Ｃ）
2016年 - 2018年 - PPARα 活性化抑制を標的としたＣ型肝炎関連肝癌の予防法の開発
科学研究費補助金, 若手研究（Ｂ）
2009年 - 2010年 - PPARα ノックアウトマウスを用いたアルコール性肝障害の病態解析と治療法の開発
科学研究費補助金, 若手研究（Ｂ）
2007年 - 2008年 - 消化管および肝臓におけるアルコール依存的炎症性障害の分子機構の解明と予防法の開発
科学研究費補助金, 基盤研究（Ｃ）
2007年 - 2008年 - 共同研究, 米国国立衛生研究所 癌研究所 代謝部門
2004年 - 肥満や脂肪肝を予防する機能性食品
- 脂肪肝・脂肪肝炎に起因する肝発癌機構の解明と治療法の開発
- 非アルコール性脂肪肝炎の病態解析と治療法の開発
- 国際医学研究・教育
- 栄養素と消化器病
- 脂質代謝と核内受容体
- 肝臓と脂肪細胞の相互関係
- メタボロミクス
社会貢献活動
教育活動実績
社会活動実績
