論文 Oral administration of Brevibacterium linens from washed cheese increases short-chain fatty acid-producing bacteria and lactobacilli in the gut microbiota of mice Animal Science Journal 2024 Author:Murakami A, Toyomoto K, Namai F, Sato T, Fujii T, Tochio T, Shimosato T.
Myogenetic oligodeoxynucleotide induces myocardial differentiation of murine pluripotent stem cells. Int J Mol Sci,24(18):14380 2023 Author:Ishioka M, Nihashi Y, Sunagawa Y, Umezawa K, Shimosato T, Kagami H, Morimoto T, Takaya T.
Development of fluorescence-labeled antibody for immune checkpoint inhibitor using engineered probiotics AMB Express,13(4) 2023 Author:Namai F, Sumiya S, Nomura N, Sato T, Shimosato T.*
Development of a single-chain fragment variable that binds to the SARS-CoV-2 spike protein produced by genetically modified lactic acid bacteria Molecular Biotechnology 2023 Author:Oshima S, Namai F, Sato T, Shimosato T..*
Assessment of lactic acid bacteria isolated from the chicken digestive tract for potential use as poultry probiotics Animal Bioscience 2023 Author:Sirisopapong S, Shimosato T., Okrathok S, Khempaka S.
Identification of a novel osteogenetic oligodeoxynucleotide (osteoDN) that promotes osteoblast differentiation in a TLR9-independent manner. Nanomaterials,12(10):1680 2022(May 14) Author:Nihashi Y, Miyoshi M, Umezawa K, Shimosato T, Takaya T.
Myogenetic oligodeoxynucleotides as anti-nucleolin aptamers inhibit the growth of embryonal rhabdomyosarcoma cells. Biomedicines,10(11):2691 2022 Author:Nohira N, Shinji S, Nakamura S, Nihashi Y, Shimosato T, Takaya T.
Myogenetic oligodeoxynucleotide restores differentiation and reverses inflammation of myoblasts aggravated by cancer-conditioned medium Muscles,1(2):111-120 2022 Author:Nihashi Y, Yamamoto M, Shimosato T, Takaya T.
Free feeding of CpG-oligodeoxynucleotide particles prophylactically attenuates allergic airway inflammation and hyperresponsiveness in mice Frontiers in Immunology,12:738041 2021(Nov. 19) Author:Okajima, T., Shigemori S*, Namai F, Ogita T, Sato T, Shimosato T.*
A soybean resistant protein-containing diet increased the production of Reg3g through the regulation of the gut microbiota and enhanced the intestinal barrier function in mice Frontiers in Nutrition,8:701466 2021(Aug. 19) Author:Ogita T, Namai F, Mikami A, Ishiguro T, Umezawa K, Uyeno Y, Shimosato T.*
Myogenetic oligodeoxynucleotide complexed with berberine promotes differentiation of chicken myoblasts. Animal Science Journal,92(1):e13597 2021(Jul. 25) Author:Nihashi Y, Shinji S, Umezawa K, Shimosato T, Ono T, Kagami H, Takaya T
Myogenetic oligodeoxynucleotide (myoDN) recovers the differentiation of skeletal muscle myoblasts deteriorated by diabetes mellitus. Frontiers in Physiology,12:679152 2021(May 24) Author:Nakamura S, Yonekura S, Shimosato T, Takaya T.
Identification of the myogenetic oligodeoxynucleotides (myoDNs) that promote differentiation of skeletal muscle myoblasts by targeting nucleolin Frontiers in Cell and Developmental Biology,6:616706 2021(Jan. 11) Author:Shinji S, Umezawa K, Nihashi Y, Nakamura S, Shimosato T, Takaya T.
Oral administration of Flavonifractor plautii, a bacteria increased with green tea consumption, promotes recovery from acute colitis in mice via suppression of IL-17 Frontiers in Nutrition,7:610946 2021 Author:Mikami A, Ogita T, Namai F, Shigemori S, Sato T, Shimosato T.*
Nasally Administered Lactococcus lactis Secreting Heme Oxygenase-1 Attenuates Murine Emphysema Antioxidants,9(1049) 2020(Oct. 27) Author:Yumoto K, Sato T*, Nakashima K, Namai F, Shigemori S, Shimosato T, Kaneko T.
Ribosome-engineered Lacticaseibacillus rhamnosus GG exhibits cell surface GAPDH accumulation and enhanced adhesion to human colonic mucin Applied and Environmental Microbiology,86(20):e01448-20 2020(Oct. 01) Author:Ishida M, Namai F, Shigemori S, Kajikawa S, Tsukagoshi M, Sato T, Ogita T, Shimosato T.*
Oral priming with oligodeoxynucleotide particles from Lactobacillus rhamnosus GG attenuates symptoms of dextran sodium sulfate-induced acute colitis in mice Animal Science Journal,91(1):e13468 2020(Oct.) Author:Shigemori S, Namai F, Ogita T, Sato T, Shimosato T.*
Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice Experimental & Molecular Medicine,52(9):1627-1636 2020(Sep. 28) Author:Namai F, Shigemori S, Ogita T, Sato T, Shimosato T.*
Construction of genetically modified Lactococcus lactis producing anti-human-CTLA-4 single-chain fragment variable Molecular Biotechnology,62(11):572-579 2020(Sep. 23) Author:Namai F, Murakami A, Ueda A, Tsukagoshi M, Shigemori S, Ogita T, Sato T, Shimosato T.*
Editorial: Nutrition, Immunity and Viral Infections Frontiers in Nutrition,7(125) 2020(Sep. 08) Author:Villena J*, Shimosato T, Vizoso-Pinto MG, Kitazawa H.*
Oral administration of Flavonifractor plautii attenuates inflammatory responses in obese adipose tissue Molecular Biology Reports,47(9):6717-6725 2020(Sep.) Author:Mikami A, Ogita T, Namai F, Shigemori S, Sato T, Shimosato T.*
Construction of genetically modified Lactococcus lactis that produces bioactive anti-interleukin-4 single-chain fragment variable Molecular Biology Reports,47(9):7039-7047 2020(Sep.) Author:Namai F, Shigemori S, Ogita T, Sato T, Shimosato T.*
Lactobacillus ingluviei C37 from chicken inhibits inflammation in LPS-stimulated mouse macrophages Animal Science Journal,91:e13436 2020(Aug. 30) Author:Tsukagoshi M, Sirisopapong M, Namai F, Ishida M, Okrathok S, Shigemori S, Ogita T, Sato T, Khempaka S*, Shimosato T.*
Oral administration of Flavonifractor plautii strongly suppresses Th2 immune responses in mice Frontiers in Immunology,11:379 2020(Feb. 28) Author:Ogita T, Yamamoto Y, Mikami A, Shigemori S, Sato T, Shimosato T.*
Cooperation of Oligodeoxynucleotides and Synthetic Molecules as Enhanced Immune Modulators Frontiers in Nutrition,6:140 2019(Aug. 27) Author:Nigar S, Shimosato T.*
Septicemia fromLactobacillus rhamnosus GG, from a Probiotic Enriched Yogurt, in a Patient with Autologous Stem Cell Transplantation Probiotics and Antimicrobial Proteins,11(1):295-298 2019 Author:Koyama S, Fujita H, Shimosato T, Kamijo A, Ishiyama Y, Yamamoto E, Ishii Y, Hattori Y, Hagiwara M, Yamazaki E, Tomita N, Nakajima H.
Recombinant mouse calcitonin gene-related peptide secreted by Lactococcus lactis inhibits lipopolysaccharide-induced inflammatory response in macrophages Animal Science Journal,89(12):1707-1711 2018(Dec. 04) Author:Namai F, Yamamoto Y, Sato T, Ogita T, Shimosato T.*
Silicosis and lung cancer: current perspectives Lung Cancer: Targets and Therapy 2018(Oct. 26) Author:Sato T, Shimosato T, Klinman DM
Regulatory Role of Heme Oxygenase-1 in Silica-induced Lung Injury Respiratory Research,19:114 2018(Aug. 01) Author:Nakashima K, Sato T, Shigemori S, Shimosato T, Shinkai M, Kaneko T.
Immune synergistic oligodeoxynucleotide from Lactobacillus rhamnosus GG enhances the immune response upon co-stimulation by bacterial and fungal cell wall components Animal Science Journal,89(10):1504-1511 2018 Author:Nigar S, Yamamoto Y, Okajima T, Sato T, Ogita T, Shimosato T*
Recombinant mouse osteocalcin secreted by Lactococcus lactis promotes glucagon-like peptide-1 induction in STC-1 cells Current Microbiology,75(1):92-98 2018 Author:Namai F, Shigemori S, Sudo K, Sato T, Yamamoto Y, Nigar S, Ogita T, Shimosato T.*
Synergistic oligodeoxynucleotide strongly promotes CpG-induced interleukin-6 production BMC Immunology,18:44 2017 Author:Nigar S, Yamamoto Y, Okajima T, Shigemori S, Sato T, Ogita T, Shimosato T.*
Class A CpG oligonucleotide priming rescues mice from septic shock via activation of platelet-activating factor acetylhydrolase Frontiers in Immunology,8:Article ID:1049 2017 Author:Yamamoto Y, Sugimura R, Watanabe T, Shigemori S, Okajima T, Nigar S, Namai F, Sato T, Ogita T, Shimosato T.*
Genetically modified Lactococcus lactis producing a green fluorescence protein-bovine lactoferrin fusion protein suppresses proinflammatory cytokine expression in LPS-stimulated RAW 264.7 cells Journal of Dairy Science,100(9):7007-7015 2017 Author:Shigemori S, Namai F, Yamamoto Y, Nigar S, Sato T, Ogita T, Shimosato T.*
Applications of genetically modified immunobiotics with high immunoregulatory capacity for treatment of inflammatory bowel diseases Frontiers in Immunology,8:Article ID:22 2017 Author:Shigemori S, Shimosato T*.
Secretion of an immunoreactive single-chain variable fragment antibody against mouse interleukin 6 by Lactococcus lactis Applied Microbiology and Biotechnology,101(1):341-349 2017 Author:Shigemori S, Ihara M, Sato T, Yamamoto Y, Nigar S, Ogita T, Shimosato T*.
The use of nanoparticles to delivery immunomodulatory oligonucleotides Wiley Interdisciplinary Reviews (WIREs): Nanomedicine and Nanobiotechnology,8(4):631-637 2016 Author:Klinman DM, Sato T, Shimosato T.
Development of a simple IgE-independent anaphylactic model using buckwheat antigen and B-type CpG oligodeoxynucleotide from Streptococcus thermophilus Animal Science Journal,87(5):710-717 2016 Author:Yamamoto Y, Shigemori S, Nigar S, Oshiro K, Wang Y, Sato T,Shimosato T*.
Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice Microbial Cell Factories,14(1):189 2015 Author:Shigemori S, Watanabe T, Kudoh K, Ihara M, Nigar S, Yamamoto Y, Suda Y, Sato T, Kitazawa H,Shimosato T*.
Intrapulmonary Delivery of CpG Microparticles Eliminates Lung Tumors Molecular Cancer Therapeutics,14(10):2198-2205 2015 Author:Sato T, Shimosato T, Ueda A, Ishigatsubo Y, Klinman DM.
ALS-associated P56S-VAPB mutation restrains 3T3-L1 preadipocyte differentiation Biochemical and Biophysical Research Communications,460(3):831-837 2015 Author:Tokutake Y, Gushima K, Miyazaki H,Shimosato T, Yonekura S.
Effect of probiotics/prebiotics on cattle health and productivity Microbes and Environments,30(2):126-132 2015 Author:Uyeno Y, Shigemori S,Shimosato T.
Inhibitory/Suppressive oligodeoxynucleotide nanocapsules as simple oral delivery devices for preventing atopic dermatitis in mice Molecular Therapy,23(2):297-309 2015 Author:Wang Y, Yamamoto Y, Shigemori S, Watanabe T, Oshiro K, Wang X, Wang P, Sato T, Yonekura S, Tanaka S, Kitazawa H,Shimosato T*.
Generation of dipeptidyl peptidase-IV-inhibiting peptides from β-lactoglobulin secreted by Lactococcus lactis BioMed Research International,:393598 2014 Author:Shigemori S, Ohshiro K, Wang P, Yamamoto Y, Wang Y, Sato T, Uyeno Y,Shimosato T*.
Histological analysis of glucagon-like peptide-1 receptor expression in chicken pancreas Cell and Tissue Research,357(1):55-61 2014 Author:Watanabe T, Nishimura K, Hosaka Y,Shimosato T, Yonekura S, Suzuki D, Takemoto C, Monir M, Hiramatsu K.
Oral administration of a fruiting body extract of Boletopsis leucomelas enhances intestinal IgA production in LPS-challenged mice Food and Agricultural Immunology,25(4):510-522 2014 Author:Shimosato T*, Kanoh J, Otani H.
Suppressive oligodeoxynucleotides synergistically enhance antiproliferative effects of anticancer drugs in A549 human lung cancer cells International Journal of Oncology,42(2):429-436 2013 Author:Takahashi R, Sato T, Klinman DM,Shimosato T, Kaneko T, Ishigatsubo Y.
Expression of the immunoreactive buckwheat major allergenic storage protein in Lactococcus lactis Applied Microbiology and Biotechnology,97(8):3603-3611 2013 Author:Shigemori S, Yonekura S, Sato T, Otani H,Shimosato T*.
Class I/II hybrid inhibitory oligodeoxynucleotide exerts Th1 and Th2 double immunosuppression FEBS Open Bio,3:41-45 2013 Author:Ito Y, Shigemori S, Sato T, Shimazu T, Hatano K, Otani H, Kitazawa H,Shimosato T*.
Oral administration of a casein phosphopeptide and phosphorylated dextrin preparations enhances intestinal IgA production and gene expression relating to the IgA production and calcium absorption in mice Milchwissenshaft-Milk Science International,67(3):289-292 2012(Jul.) Author:Ikuno Y, Banno M,Shimosato T, Otani H.
Expression of a biologically active GFP-αS1-casein fusion protein in Lactococcus lactis Current Microbiology,64(6):569-575 2012 Author:Shigemori S, Yonekura S, Sato T, Nakanishi M, Otani H,Shimosato T*.
Serum heme oxygenase-1 as a marker of lung function declinein patients with chronic silicosis Journal of Occupational and Environmental Medicine,54(12):1461-1466 2012 Author:Sato T, Saito Y, Inoue S,Shimosato T, Takagi S, Kaneko T, Ishigatsubo Y.
Immunobiotic lactic acid bacteria beneficially regulate immune response triggered by poly(I:C) in porcine intestinal epithelial cells. Veterinary Research,42(1):111 2011 Author:Hosoya S, Villena J, Shimazu T,Tohno M, Fujie H, Chiba E,Shimosato T, Aso H,Suda Y, Kawai Y, Saito T, Alvarez S, Ikegami S, Itoh H, Kitazawa H.
Immunobiotic Lactobacillus jensenii elicit anti-inflammatory activity in porcine intestinal epithelial cells by modulating negative regulators of the toll-like receptor signaling pathway. Infection and Immunity,80(1):276-288 2011 Author:Shimazu T, Villena J, Tohno M, Fujie H, Hosoya S,Shimosato T, Aso H, Suda Y, Kawai Y, Saito T, Alvarez S, Ikegami S, Itoh H,Kitazawa H.
Immunobiotic Lactobacillus strains augment NLRP3 expression in newborn and adult porcine gut-associated lymphoid tissues Veterinary Immunology and Immunopathology,144(3-4):410-416 2011 Author:Tohno M,Shimosato T, Aso H, Kitazawa H.
Toll-like receptor-2 activating bifidobacteria strains differentially regulate inflammatory cytokines in porcine intestinal epithelial cell culture system: finding new anti-inflammatory immunobiotics FEMS Immunology and Medical Microbiology,63:129-139 2011 Author:Fujie, H, Villena J, Tohno M, Morie K, Shimazu T, Aso H, Suda Y,Shimosato T, Iwabuchi N, Xiao JZ, Yaeshima T, Iwatsuki K, Saito T, Numasaki M, Kitazawa H.
Effect of Lactobacillus pentosus ONRIC b0240 on intestinal IgA production in mice fed differing levels of protein Journal of Agricultural and Food Chemistry,59(6):2646-2651 2011 Author:Shimosato T*, Tomida K, Otani H.
Anti-allergic effects of a mixture of Saccharomyces cerevisiae and its specific goat’s milk immunoglobulin G-rich fraction on ovalbumin-sensitized BALB/c mice Milchwissenshaft-Milk Science International,66(1):7-10 2011 Author:Sekimura Y,Shimosato T, Otani H.
Accelerated Wound Healing Mediated by Activation of Toll-like Receptor 9. WoundRepair and Regeneration,18(6):586-593 2010 Author:Sato T, Yamamoto M,Shimosato T, Klinman DM.
Oral Administration of Phosphorylated Dextran Regulates Immune Response in Ovalbumin-Immunized Mice Asian-Australasian Journal of Animal Science,23(1):106-115 2010 Author:Nagasawa C, Nishimura-Uemura J, Tohno M,Shimosato T, Kawai Y, Ikegami S, Oda M, Saito T, Kitazawa H.
CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9 Biochemical and Biophysical Research Communications,394(1):81-86 2010 Author:Shimosato T*, Fujimoto M, Tohno M, Sato T, Tateo M, Otani H, Kitazawa H*.
Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ Animal Science Journal,80(5):597-604 2009 Author:Shimosato T*, Tohno M, SatoT, Nishiura J, Kawai Y, Saito T, Kitazawa H.
Utilization of the porcine system to study lymphotoxin-β regulation in intestina lymphoid tissue. Biochemical Genetics,47(1-2):126-136 2009 Author:Shimazu T, Tohno M, Katoh S,Shimosato T, Aso H, Kawai Y, Saito T, Kitazawa H.
Immunostimulatory oligodeoxynucleotide containing TTTCGTTT motif from Lactobacillus rhamnosus GG DNA potentially suppresses OVA specific IgE production in mice. Scandinavian Journal of Immunology,67(4):370-376 2008 Author:Iliev ID, Tohno M, Kurosaki D,Shimosato T, He F, Hosoda M, Saito T, Kitazawa H.
Suppressive Oligodeoxynucleotides Inhibit Silica-induced Pulmonary Inflammation The Journal of Immunology,180(11):7648-7654 2008 Author:Sato T,Shimosato T, Alvord WG, Klinman DM.
Advanced molecular immunoassay system for immunobiotic lactic acid bacteria using a transfectant of Toll-like receptor 2. Animal Science Journal,78(2):195-205 2007 Author:Tohno M,Shimosato T, Kawai Y Aso H, Ikegami S, Taketomo N, Saito T, Kitazawa H.
Development of molecular immunoassay system for probiotics via toll-like receptors based on food immunology. Animal Science Journal,79(1):11-21 2007 Author:Kitazawa H, Tohno M,Shimosato T, Saito T.
Enzymatic digestion of the milk protein beta-casein releases potent chemotactic peptide(s) for monocytes and macrophages. International Immunopharmacology,7(9):1150-1159 2007 Author:Kitazawa H, Yonezawa K, Tohno M,Shimosato T, Kawai Y, Saito T, Wang JM.
Strong immunostimulatory activity of AT-oligodeoxynucleotide requires a six-base loop with a self-stabilized 5'-C…G-3'stem structure. Cellular Microbiology,8(3):485-495 2006 Author:Shimosato T, Kimura T, Tohno M, Iliev ID, Katoh S, Itoh Y, Kawai Y, Sasaki T, Saito T, Kitazawa H.
An immunostimulatory DNA sequence from a probiotic strain of Bifidobacterium longum inhibits IgE production in vitro. FEMS Immunology and Medical Microbiology,46(3):461-469 2006 Author:Takahashi N, Kitazawa H,Shimosato T, Iwabuchi N,Xiao JZ, IwatsukiK, KokuboS Saito T.
Toll-like receptor 2 and 9 are expressed and functional in gut-associated lymphoid tissues of presuckling newborn swine. Veterinary Research,37(6):791-812 2006 Author:Tohno M,Shimosato T, Moue M, Aso H, Watanabe K, Kawai Y, Yamaguchi T, Saito T, Kitazawa H.
A swine Toll-like receptor 2-expressing transfectant as a potential primary screening system for immunobiotic microorganisms. FEMS Immunology and Medical Microbiology,44(3):283-288 2005 Author:Tohno M, Kitazawa H,Shimosato T, Matsumoto M, Katoh S, Kawai Y,Saito T.
Strong immunostimulation inmurine immune cells by Lactobacillus rhamnosus GG DNA containing novel oligodeoxynucleotide pattern. Cellular Microbiology,7(3):403-414 2005 Author:Iliev ID, Kitazawa H,Shimosato T, Katoh S, Saito T.
Toll-like receptor2 is expressed on the intestinal M cells in swine. Biochemicaland BiophysicalResearch Communications,330(2):547-554 2005 Author:Tohno M*,Shimosato T*, Kitazawa H, Katoh S,Iliev ID, Watanabe K, Kawai Y,Aso H, Yamaguchi T, Saito T. *Tohno M. and Shimosato T. contributed equally to this work.
Augmentation of TH-1 type responseby immunoactive AT oligonucleotide from lactic acid bacteria via Toll-like receptor 9 signaling. Biochemical and Biophysical Research Communications,326(4):782-787 2005 Author:Shimosato T, Kitazawa H, Tohno M, Katoh S, Iliev ID, Nagasawa C, Kawai Y, Saito T.
Toll-like receptor 9 is expressed on follicle-associated epithelia containing M cells in swine Peyer’s patches. Immunology Letters,98(1):83-89 2005 Author:Shimosato T, Tohno M, KitazawaH, Katoh S, Watanabe K, KawaiY, Aso H, YamaguchiT, Saito T.
Dextran from Leuconostoc mesenteroides augments immunostimulatory effects by the introduction of phosphate groups. Journal of Food Protection,67(8):1719-1724 2004 Author:Sato T, Nishimura-Uemura J,Shimosato T, Kawai Y, Kitazawa H, Saito T.
Cloning and Characterization of Swine Interleukin-17, Preferentially Expressed in the Intestines. Journal of Interferon and Cytokine Research,24(9):553-559 2004 Author:Katoh S, Kitazawa H,Shimosato T, Tohno M, KawaiY, Saito T.
Development of immune assay system for both CpG and non-CpG DNA from lacticacid bacteria using a transfectant of swine Toll-like receptor 9 Animal Science Journal,75:377-382 2004 Author:Shimosato T, Kitazawa H, Tohno M, Katoh S, Kawai Y, Saito T.
Immunostimulatory oligonucleotide, CpG-like motif exists in Lactobacillus delbrueckii ssp. bulgaricus NIAI B6. International Journal of Food Microbiology,85(1-2):11-21 2003 Author:Kitazawa H, WatanabeH,Shimosato T, Kawai Y, Itoh T, Saito T.
Swine Toll-like receptor 9 recognizes CpG motifs of human cell stimulant. Biochemica et Biophysica Acta,1627(1):56-61 2003 Author:Shimosato T, Kitazawa H, Katoh S, Tomioka Y, Karima R, Ueha S, Kawai Y, Hishinuma T, Matsushima K, Saito T.
講演・口頭発表等 Bacterial changes associated with the rpsL gene mutation in Lacticaseibacillus rhamnosus GG The 11th Asian Conference for Lactic Acid Bacteria 2021(Nov. 06) Presenter:Masami Tsukagoshi, Fu Namai, Suguru Shigemori, Takeshi Shimosato
Lactobacillus ingluviei C37 from broiler inhibits inflammation in LPS-stimulated mouse macrophages (English Presentation Award) The 129th Annual Meeting of Japanese Society of Animal Science 2021(Sep. 15) Presenter:Masami Tsukagoshi, Fu Namai, Suguru Shigemori, Ogita Tasuku, Takeshi Shimosato
Construction of genetically modified lactic acid bacteria producing anti-IL31Ra single-chain Fragment variable (English Presentation Award) The 129th Annual Meeting of Japanese Society of Animal Science 2021(Sep. 15) Presenter:Aito Murakami, Fu Namai, Suguru Shigemori, Ogita Tasuku, Takeshi Shimosato
Construction of a genetically modified Lactococcus lactis producing single chain Fv against vascular endothelial growth factor 13th International Scientific Conference on Probiotics, Prebiotics, Gut Mirobiota and Health 2019(Jun. 20) Presenter:Masami Tsukagoshi, Fu Namai, Kohei Watanabe, Minako Iwai, Suguru Shigemori, Tasuku Ogita, Takashi Sato, Takeshi Shimosato
Ribosome engineering enhances production of p40, a Lactobacillus rhamnosus GG-derived soluble protein, in S12 mutant strains 13th International Scientific Conference on Probiotics, Prebiotics, Gut Mirobiota and Health 2019(Jun. 20) Presenter:Shoko Kajikawa, Minori Ishida, Fu Namai, Suguru Shigemori, Tasuku Ogita, Takashi Sato, Takeshi Shimosato
Oral administration of a genetically modified osteocalcin-secreting Lactococcus lactis improves carbohydrate metabolism in high-fat diet-induced obese mice 13th International Scientific Conference on Probiotics, Prebiotics, Gut Mirobiota and Health 2019(Jun. 20) Presenter:Fu Namai, Suguru Shigemori, Tasuku Ogita, Takashi Sato, Takeshi Shimosato
Oral delivery of CpG-oligodeoxynucleotide from lactic acid bacteria ameliorates high-fat-diet-induced obesity in mice 2018 Symposium of Korean Society for Lactic Acid Bacteria and Probiotics, Probiotics, Postbiotics, and Gut Health 2018(Nov. 30) Presenter:Ryu Sugimura, Tasuku Ogita, Takeshi Shimosato
Flavonifractor plautii exerts Th1/Th2 immunomodulatory effects in mice 2018 Symposium of Korean Society for Lactic Acid Bacteria and Probiotics, Probiotics, Postbiotics, and Gut Health 2018(Nov. 30) Presenter:Chika Fukasawa, Tasuku Ogita, Takeshi Shimosato
Flavonifractor plautii inhibits inflammatory responses in lipopolysaccharide-stimulated RAW 264.7 cells and alleviates acute-colitis in mice 2018 Symposium of Korean Society for Lactic Acid Bacteria and Probiotics, Probiotics, Postbiotics, and Gut Health 2018(Nov. 30) Presenter:Ayane Mikami, Tasuku Ogita, Takeshi Shimosato
Construction of Oligodeoxynucleotide Particles using Glycosylated Carbonate Apatite and Targeted Delivery to Macrophages 18th AAAP Congress 2018(Aug. 01) Presenter:Shuichiro Yamashina, Mitsuaki Goto, Takeshi Shimosato
Recombinant mouse calcitonin gene-related peptidesecreted by Lactococcus lactis inhibits lipopolysaccharide-induced inflammatory response in macrophages 18th AAAP Congress 2018(Aug. 01) Presenter:Fu Namai, Tasuku Ogita, Takeshi Shimosato
Advanced Application of Ribosome Engineering in Lactobacillus rhamnosus GG 18th AAAP Congress 2018(Aug. 01) Presenter:Minori Ishida, Fu Namai, Tasuku Ogita, Takeshi Shimosato
Immunoregulatory function of Flavonifractor plautii 18th AAAP Congress 2018(Aug. 01) Presenter:Tasuku Ogita, Fu Namai, Ayane Mikami, Takeshi Shimosato
Class-B Oligodeoxynucleotide Derived from a Lactic Acid Bacterium Induces Apoptosis in Spleen Cells 18th AAAP Congress 2018 2018(Aug. 01) Presenter:Nobuhiro Ambe, Yoshinari Yamamoto, Tasuku Ogita, Takeshi Shimosato
Construction of genetically modified Lactococcus lactissecreting bioactive osteocalcin International Dairy Federation (IDF) World Dairy Summit 2017 2017(Nov. 01) Presenter:Fu Namai, Suguru Shigemori, Tasuku Ogita, Takeshi Shimosato
Free-feeding of DNA nanocapsules containing CpG oligodeoxynucleotide from Streptococcus thermophilus International Dairy Federation (IDF) World Dairy Summit 2017 2017(Nov. 01) Presenter:Takuma Okajima, Yoshinari Yamamoto, Tasuku Ogita, Takeshi Shimosato
Effect of Fishery Related Activities on the Food and Nutrition Situation of Indigenous Community in Bangladesh: A Study of Adolescent girl Proceedings of the 17th AAAP Congress 2016(Aug. 25) Presenter:Shireen Nigar, Takeshi Shimosato, Abu Torab Md. Abdur Rahim
Immunostimulatory oligodeoxynucleotide from lactic acid bacteria promotes the anaphylaxis to ovalbumin in mice Proceedings of the 17th AAAP Congress 2016(Aug. 25) Presenter:Yoshinari Yamamoto, Takuma Okajima, Tasuku Ogita, Takeshi Shimosato
Dose-comparison study of Lactococcus lactis producing heme oxygenase-1 for treatment of dextran sulfate sodium-induced acute colitis in mice Proceedings of the 17th AAAP Congress 2016(Aug. 25) Presenter:Suguru Shigemori, Tasuku Ogita, Takeshi Shimosato
CpG oligodeoxynucleotide from Streptococcus thermophilus induces type 2 innate lymphoid cells（Young Scientists Award/JSAS Excellent Presentation Award受賞） Proceedings of the 17th AAAP Congress 2016(Aug. 23) Presenter:Takuma Okajima, Yoshinari Yamamoto, Tasuku Ogita, Takeshi Shimosato
Construction of genetically modified Lactococcus lactis expressing buckwheat protein Fagag1 with strong allergenicity 2015 ADSA-ASAS Joint Annual Meeting (JAM) 2015(Jul. 14) Presenter:Suguru Shigemori, Yoshinari Yamamoto, Kazushi Oshiro, Pengfei Wang, Yeqin Wang, Takashi Sato,Takeshi Shimosato
Production of recombinant β-lactoglobulin in Lactococcus lactis and generation of a bioactive peptide with incretin-inactivation activity 2015 ADSA-ASAS JointAnnual Meeting (JAM) 2015(Jul. 14) Presenter:Kazushi Oshiro, Suguru Shigemori, Yoshinari Yamamoto, Pengfei Wang, Yeqin Wang, Takashi Sato,Takeshi Shimosato
Development of an anaphylactic model of buckwheat using B-type CpG oligodeoxynucleotides from lactic acid bacteria 2015 ADSA-ASAS Joint Annual Meeting (JAM) 2015(Jul. 14) Presenter:Yoshinari Yamamoto, Suguru Shigemori, Kazushi Oshiro, Pengfei Wang, Yeqin Wang, Takashi Sato,Takeshi Shimosato
Intracellular expression of cow’s milk allergens in genetically modified Lactococcus lactis Proceedings of the 16th AAAP Congress 2014(Nov. 12) Presenter:Suguru Shigemori, Yoshinari Yamamoto, Pengfei Wang, Yeqin Wang,Takeshi Shimosato
Strong immunostimulatory activity of oligodeoxynucleotide motifs from lactic acid bacteria Proceedings of the 16th AAAP Congress 2014(Nov. 12) Presenter:Yoshinari Yamamoto, Suguru Shigemori, Pengfei Wang, Yeqin Wang,Takeshi Shimosato
インターロイキン6特異的抗体を分泌する乳酸菌組換え体の構築（若手優秀ポスター賞受賞） 平成26年度日本酪農科学シンポジウム 2014(Sep. 12) Presenter:重盛駿, 大城和士, Wang Pengfei, 山本祥也, Wang Yeqin, 下里剛士
Expression of immunoreactive αS1-casein in Lactococcus lactis as a treatment strategy for milk allergy International Dairy Federation, World Dairy Summit 2013 2013(Oct. 28) Presenter:Suguru Shigemori, Hajime Otani,Takeshi Shimosato
Immunostimulatory oligodeoxynucleotide from yogurt starter bacteria Streptococcus thermophilus, strongly induces interleukin 33 International Dairy Federation, World Dairy Summit 2013 2013(Oct. 28) Presenter:Yusuke Ito, Suguru Shigemori, Hajime Otani, Haruki Kitazawa,Takeshi Shimosato
CpG oligodeoxynucleotides promote wound healing in airway epithelial cells American Thoracic Society Annual Meeting 2011 2011 Presenter:Sato T, Miyazawa N, KlinmanDM,Shimosato T, Takahashi R, Tsukahara T, Hayashi M, Yamamoto M, Tomaru K, Kaneko T, Ishigatsubo Y.
Toll-like receptor 4recognizes extracellular polysaccharide from Lactococcus lactis subsp. cremoris 4th congress of european microbiologists FEMS 2011 Presenter:Tohno M,Shimosato T, Aso H, Kitazawa H.
Suppressive Oligodeoxynucleotide Synergistically Enhances The Antiproliferative Effect Of Anti-cancer Drug In Human Lung Cancer Cells American Thoracic Society Annual Meeting 2011 2011 Presenter:Takahashi R, Sato T, Miyazawa N, Klinman DM,Shimosato T, Hayashi M, Yamamoto M, Tomaru K, Tsukahara T, Kaneko T, Ishigatsubo Y.
Evaluation of Anti-Inflammatory Immunobiotics in Porcine Intesinal Epithelial Cells International ScientificConference on Probiotics andPrebiotics - IPC2010 2010 Presenter:Kitazawa H, Shimazu T, Tohno M, Villena J, Hosoya S, Fujie H, Suda Y,Shimosato T, Aso H, Makino S, Ikegami S, Kawai Y, Saito T.
Effect of immunobiotics on the immune performance and productivity of pigs International Scientific Conference on Probiotics and Prebiotics - IPC2010 2010 Presenter:SudaY, TakahashiY, Tohno M, Villena Julio, Hosoya S, Fujie H,Shimosato T, Kobashi J, Ishida M, Aso H, Kawai Y, Saito T, Makino S, Ikegami S, Kitazawa H.
Accelerated wound healing in mice by local administration of sustained-release CpG oligodeoxynucleotide. 97th AAI Annual Meeting 2010 Presenter:Sato T,Shimosato T, Klinman DM.
The novel immunostimulatory activities of CpG oligodeoxynucleotides from Streptococcus thermophilus ADSA-PSA-AMPA-CSAS-ASAS Joint Annual Meeting (JAM) 2010 Presenter:Shimosato T, Fujimoto M, Tohno M, Sato T, Otani H, Kitazawa H.
Immunoregulation of immunobiotic lactic acid bacterial DNA and their advanced application to Food Science Shinshu University International Symposium 2010 in Ina, Sustainable Agriculture and Environment: Asian Network II, proceedings 2010 Presenter:Takeshi Shimosato
CpG oligodeoxynucleotide from Streptococcus thermophilus regulates anti-inflammatory responses ADSA-CSAS-ASAS 2009 Joint Annual Meeting 2009 Presenter:Shimosato T, Tohno M, Sato T, Kitazawa H
REGULATION OF INFLAMMATORY RESPONSE BY IMMUNOBIOTICS IN SWINE INTESTINAL EPITHELIAL CELLS VIA MKP-1 The 9th World Congress on Inflammation 2009 Presenter:ShimazuT, Tohno M, Hosoya S, Fujie H,Shimosato T, Aso H, Suda Y, KawaiY, Saito T, Kitazawa H.
CpG oligodeoxynucleotide from Streptococcus thermophilus lacZ strongly induces the expression of interleukin-33 in murine immune cells The 9th World Congress on Inflammation 2009 Presenter:Shimosato T, Tohno M, Sato T, Tateo M, Otani H, Kitazawa H
Suppressive oligodeoxynucleotides improve outcome in murine silicosis American Thoracic Society Annual Meeting 2008 2008 Presenter:SatoT,Shimosato T, Klinman DM
Immuno-stimulatory AT oligodeoxynucleotide from Lactobacillus gasseri requires a specific self-stabilized structure ADSA-ASAS 2008 Joint Annual Meeting 2008 Presenter:Shimosato T, Tohno M, Sato T, Kawai Y, Saito T, Kitazawa H
Immune responses of Immunobiotics and Immunogenics via Toll-like receptors and their advancedapplication to Food immunology 2nd International Bio-microcosmos Workshop 2006 Presenter:Kitazawa H,Shimosato T, Tohno M, Saito T
Development of a novel immunoassay system for immunobiotics that modulate intestinal immunity through Toll-likereceptor 2 ADSA-ASAS 2006 Joint Annual Meeting 2006 Presenter:Tohno M,Shimosato T, Kawai, Y, Saito T. Kitazawa H,
Immunobiotic lactic acid bacteria induce immune responses in immature gut-associatedlymphoid tissues via Toll-likereceptors 2 and 9 ADSA-ASAS 2006 Joint Annual Meeting 2006 Presenter:Kitazawa H, Tohno M,Shimosato T, Aso H, Kawai, Y, Saito T.
Swine intestinal immunity via Toll-like receptors and its advanced application to Food immunology International Symposium on Recent Advances in Animal Science 2005 Presenter:Kitazawa H,Shimosato T, Tohno M, Saito T
AT oligonucleotide from"Immunobiotic"Lactobacillus gasseri augments immune responses via Toll-like receptor 9 signaling ADSA-ASAS 2004 Joint Annual Meeting 2004 Presenter:Shimosato T, Kitazawa H, Tohno M, Katoh S, Kawai, Y, Saito T.
Immunostimulatory activities of a novel AT oligonucleotide from "Immunobiotic" Lactobacillus gasseri on swine Peyer's patch cells Journal of Dairy Science 87 417 2004 Presenter:Kitazawa H,Shimosato T, Katoh S, Tohno M, Kawai, Y, Saito T.
Preparation of goat milk anti-Saccharomyces cerevisiae immunoglobulin G (IgG)-rich fraction and immunological functions of mice orally administered a mixture of the antigen and its specific IgG-rich fraction Milk Science,58(3):119-128 2009 Author:Sekimura Y, Onodera N, Banno M, Hata I, HamanoK,Shimosato T, Hajime O.
Swine intestinal immunity via Toll-like Receptors and its advanced application to food immunology. Journal of Integrated Field Science,3:9-14 2006 Author:Kitazawa H,Shimosato T, Tohno M, Saito T.
Immunostimulatory Activities of Lactic Acid Bacteria via Toll-like Receptors. Japanese Journal of Lactic Acid Bacteria,16(1):11-20 2005 Author:Kitazawa H,Shimosato T, TohnoM, Saito T.
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