書籍等出版物 Isolation and analysis of a genome-edited single-hepatocyte from a Cas9 transgenic mouse line., Methods Mol Biol. 1874 , 257-271 2019 Author:Sakurai T, Kamiyoshi A, Ohtsuka M, Gurumurthy CB, Sato M, Shindo T.
Noninheritable maternal factors useful for genetic manipulation in mammals., Results Probl Cell Differ. 63 , 495-510 2017 Author:Sakurai T, Shindo T, Sato M.
Oocytes Maternal information and functions, Springer , 495-510 2017 Author:Sakurai T, Shindo T, Sato M
循環器疾患 State of arts Ver.2 発生工学による動脈硬化モデル, 医歯薬出版株式会社 2001 Author:新藤隆行
論文 Role of adrenomedullin-2/intermedin in the pathogenesis of neovascular age-related macular degeneration. Lab Invest. ,103(4):100038 2023 Author:Kakihara S, Matsuda Y, Hirabayashi H, Imai A, Iesato Y, Sakurai T, Kamiyoshi A, Tanaka M, Ichikawa-Shindo Y, Kawate H, Zhao Y, Zhang Y, Guo Q, Li P, Onishi N, Murata T, Shindo T.
An Myh11 single lysine deletion causes aortic dissection by reducing aortic structural integrity and contractility. Sci Rep.,12(1):8844 2022 Author:Negishi K, Aizawa K, Shindo T, Suzuki T, Sakurai T, Saito Y, Miyakawa T, Tanokura M, Kataoka Y, Maeda M, Tomida S, Morita M, Kario K, Nagai R, Imai Y.
Receptor activity modifying protein RAMP sub-isoforms and their functional differentiation, which regulates functional diversity of adrenomedullin. Biology.,11(5):788 2022 Author:Shindo T, Tanaka M, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Sakurai T.
Studies on safety and efficacy of particles containing a mixture of hydroxyapatite-argentum-titanium oxide (HAT) and sheets coated with HAT particles to be used in masks to improve nasal allergy: II. Cellular, in vivo, and clinical studies. Eur Arch Otorhinolaryngol.,279(9):4425-4433 2022 Author:Okazaki N, Yamaki D, Takei T, Shimizu M, Kamatani N, Shindo T.
Calcitonin gene-related peptide is not involved in neuropathic pain induced by partial sciatic nerve ligation in mice. Neurosci Lett.,778:136615 2022 Author:Ishida K, Tanaka S, Shen D, Matsui S, Fuseya S, Shindo, Kawamata M.
Studies on safety and efficacy of particles containing a mixture of hydroxyapatite–argentum–titanium oxide (HAT) and sheets coated with HAT particles to be used in masks to improve nasal allergy: I. In vitro studies. The Allergy in Practice,42(3):37-46 2022 Author:Okazaki N, Yamaki D, Takei T, Shimizu M, Kamatani N, Shindo T.
Adrenomedullin-RAMP2 system ameliorates pulmonary fibrosis by regulating TGF-β-Smads pathway and differentiation of myofibroblasts. Endocrinology.,162(8):1-22 2021 Author:Wei Y, Tanaka M, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Cui1 N, Kakihara S, Zhao Y, Aruga K, Sanjo H, Shindo T.
Adrenomedullin-RAMP2 and -RAMP3 systems regulate cardiac homeostasis during cardiovascular stress. Endocrinology.,162(3):1-20 2021 Author:Cui N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Tanaka M, Wei Y, Kakihara S, Zhao Y, Aruga K, Kawagishi H, Nakada T, Yamada M, Shindo T.
Production of single- and multiple-gene-modified mice via maternal SpCas9-based gene editing. STAR Protoc.,2(2):100509 2021 Author:Sakurai T, Shindo T.
Adrenomedullin-RAMP2 system ameliorates subretinal fibrosis by suppressing epithelial-mesenchymal transition in age-related macular degeneration. Am J Pathol. ,191(4):652-668 2021 Author:Tanaka M, Kakihara S, Hirabayashi K. Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Cui N, Wei Y, Zhao Y, Aruga K, Yamauchi A, Murata M, Shindo T.
Mid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a cross-sectional study. Sci Rep. ,11(1):305 2021 Author:Koyama T, Kuriyama N, Suzuki Y, Saito S, Tanaka R, Iwao M, Tanaka M, Maki T, Itoh H, Ihara M, Shindo T, Uehara R.
Investigation of the therapeutic mechanism of subthreshold micropulse laser irradiation in retina. Graefes Arch Clin Exp Ophthalmol. ,285(5):1039-1047 2020 Author:Hirabayashi K, Kakihara S, Tanaka M, Shindo T, Murata T.
Deficiency of the adrenomedullin-RAMP3 system suppresses metastasis through the modification of cancer-associated fibroblasts. Oncogene. ,39(9):1914-1930 2020 Author:Dai K, Tanaka M, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Cui N, Wei Y, Tanaka M, Kakihara S, Matsui S, Shindo T.
Production of genetically engineered mice with higher efficiency, lower mosaicism, and mulitiplexing capability using maternally expressed Cas9. Sci Rep.,10(1):1091, 2020 Author:Sakurai T, Kamiyoshi A, Kawate H, Watanabe S, Sato M, Shindo T.
Placental extract ameliorates liver fibrosis in a methionine- and choline-deficient diet-induced mouse model of non-alcoholic steatohepatitis. Biomedical Research.,41(1):1–12 2020 Author:Yamauchi A. Tone T, Tokedo A, Igarashi K, Sugimoto K, Miyai H, Deng D, Nakamura J, Lim HS, Kaku T, Hirano E, Shindo T.
Placental extract suppresses cardiac hypertrophy and fibrosis in an angiotensin II-induced cachexia model in mice Heliyon.,5(10):e02655. 2019 Author:Yamauchi A, Kamiyoshi A, Sakurai T, Miyazaki H, Hirano E, Lim HS, Kaku T, Shindo T.
Porcine placental extract facilitates memory and learning in aged mice. Food Sci Nutr. ,(7):2995–3005 2019 Author:Yamauchi A, Tone T, Sugimoto K, Lim HS, Kaku T, Tohda C, Shindo T, Tamada K, Mizukami Y, Hirano E.
Endogenous calcitonin gene-related peptide deficiency exacerbates postoperative lymphedema by suppressing lymphatic capillary formation and M2 macrophage accumulation. Am J Pathol. ,189(12):2487-2502 2019 Author:Matsui S, Tanaka M, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Dai K, Cui N, Wei Y, Tanaka M, Kakihara S, Nakamura K, Yamauchi A, Ishida K, Tanaka S, Kawamata M, Shindo T.
Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism Heliyon.,10;5(5):e01637 2019 Author:Yamauchi A. Kamiyoshi A, Sakurai T, Miyazaki H, Hirano E, Lim HS, Kaku T, Shindo T. Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism
Regulation of cardiovascular development and homeostasis by the adrenomedullin-RAMP system Peptides.,111:55-61 2019 Author:Shindo T, Tanaka M, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Sakurai T
Development of a novel model of central retinal vascular occlusion and therapeutic potential of adrenomedullin-RAMP2 system Am J Pathol.,189(2):449-466 2019 Author:Hirabayashi K, Tanaka M, Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Dai K, Cui N, Wei Y, Nakamura K, Iida S, Matsui S, Yamauchi A, Murata T, Shindo T
Bindel-PCR: a novel and convenient method for identifying CRISPR/Cas9-induced biallelic mutants through modified PCR using Thermus aquaticus DNA polymerase Sci Rep,9:9923. 2019 Author:Sakurai T, Kamiyoshi A, Takei N, Watanabe S, Sato M , Shindo T.
Endogenous calcitonin gene-related peptide suppresses ischemic brain injuries and progression of cognitive decline J Hypertens.,36(4):876-891 2018 Author:Zhai L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Xian X, Hirabayashi K, Dai K, Cui N, Tanimura K, Liu T, Wei Y, Tanaka M, Tomiyama H, Yamauchi A,Igarashi K, Shindo T
RAMP3 deficiency enhances postmenopausal obesity and metabolic disorders Peptides.,110:10-18 2018 Author:Liu T, Kamiyoshi A, Tanaka M, Iida S, Sakurai T, Ichikawa-Shindo Y, Kawate H, Hirabayashi K, Dai K, Cui N, Tanaka M, Wei Y, Nakamura K, Matsui S, Yamauchi A, Shindo T
Placental extract ameliorates non-alcoholic steatohepatitis (NASH) by exerting protective effects on endothelial cells Heliyon. 2017 Author:Yamauchi A, Kamiyoshi A, Koyama T, Iinuma N, Yamaguchi S, Miyazaki H, Hirano E, Kaku T, Shindo T
Adrenomedullin suppresses vascular endothelial growth factor-induced vascular hyperpermeability and Inflammation in retinopath Am J Phthol.,187(5):999-1015 2017 Author:Imai A, Toriyama Y, Iesato Y, Hirabayashi K, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Liu T, Xian X, Zhai L, Dai K, Tanimura K, Liu T, Cui N, Yamauchi A, Murata T, Shindo T"
Vasoprotective activities of the adrenomedullin-RAMP2 system in endothelial cells. Endocrinology.,158(5):1359−1372 2017 Author:Xian X, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Tanaka M, Koyama T, Kawate H, Yang L, Liu T, Imai A, Zhai L, Hirabayashi K, Dai K, Tanimura K, Liu T, Cui N, Igarashi K, Yamauchi A, Shindo T.
Endogenous calcitonin gene-related peptide regulates lipid metabolism and energy homeostasis in male mice. Endocrinology.,158(5):1194-1206 2017 Author:Liu T, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Yang L, Tanaka M, Xian X, Imai A, Zhai L, Hirabayashi K, Dai K, Tanimura K, Liu T, Cui N, Igarashi K, Yamauchi A, Shindo T.
Fluorescent protein tagging of endogenous protein in brain neurons using CRISPR/Cas9-mediated knock-in and in utero electroporation techniques. Sci Rep,6:35861 2016(Oct.) Author:Uemura T, Mori T, Kurihara T, Kawase S, Koike R, Satoga M, Cao X, Li X, Yanagawa T, Sakurai T, Shindo T, Tabuchi K.
The endothelial adrenomedullin-RAMP2 system regulates vascular integrity and suppresses tumour metastasis. Cardiovasc Res,111(4):398-409 2016(Sep.) Author:Tanaka M, Koyama T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Liu T, Xian X, Imai A, Zhai L, Hirabayashi K, Owa S, Yamauchi A, Igarashi K, Taniguchi S, Shindo T.
Adrenomedullin: A potential therapeutic target for retinochoroidal disease. Prog Retin Eye Res,52:112-29 2016(May) Author:Iesato Y, Yuda K, Chong KT, Tan X, Murata T, Shindo T, Yanagi Y.
Effects of Adrenomedullin on Doxorubicin-Induced Cardiac Damage in Mice. Biol Pharm Bull,39(5):737-46 2016(May) Author:Yoshizawa T, Takizawa S, Shimada S, Tokudome T, Shindo T, Matsumoto K.
Importance of Endogenous Atrial and Brain Natriuretic Peptides in Murine Embryonic Vascular and Organ Development. Endocrinology,157(1):358-67 2016(Jan.) Author:Tokudome T, Kishimoto I, Shindo T, Kawakami H, Koyama T, Otani K, Nishimura H, Miyazato M, Kohno M, Nakao K, Kangawa K.
Rac1-Mediated Activation of Mineralocorticoid Receptor in Pressure Overload-Induced Cardiac Injury. Hypertension,67(1):99-106 2016(Jan.) Author:Ayuzawa N, Nagase M, Ueda K, Nishimoto M, Kawarazaki W, Marumo T, Aiba A, Sakurai T, Shindo T, Fujita T.
A non-inheritable maternal Cas9-based multiple-gene editing system in mice. Sci Rep,6:20011 2016(Jan.) Author:Sakurai T, Kamiyoshi A, Kawate H, Mori C, Watanabe S, Tanaka M, Uetake R, Sato M, Shindo T.
Pathophysiological roles of adrenomedullin-RAMP2 system Ochanomizu igaku zasshi,63(2):331-338 2015 Author:Ichikawa-Shindo Y, Sakurai T, Kamiyoshi A, Kawate H, Koyama T, Yoshizawa T, Shindo T.
Adrenomedullin-RAMP2 system in vascular endothelial cells J. Atheroscler. Thromb,22(7):647-653 2015 Author:Koyama T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Shindo T.
Pathophysiological function of endogenous calcitonin gene-related peptide in ocular vascular diseases Am J Pathol.,185(6):1783-1794 2015 Author:Toriyama Y, Iesato Y, Imai A, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Igarashi K, Tanaka M, Liu T, Xian X, Zhai L, Owa S, Murata T, Shindo T.
Pathophysiological roles of adrenomedullin and its receptor activity modifying system. Folia Pharmacol. Jpn,143(5):232-235 2014 Author:Shindo T, Sakurai T, Kamiyoshi A, Shindo Y, Kawate H, Koyama T.
Functional differentiation of RAMP2 and RAMP3 in their regulation of vascular system J Mol Cell Cardiol.,77:73-85 2014 Author:Yamauchi A, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Igarashi K, Toriyama Y, Tanaka M, Liu T, Xian X, Imai A, Zhai L, Owa S, Arai T, Shindo T.
Pathophysiological roles of adrenomedullin-RAMP2 system in acute and chronic cerebral ischemia Peptides.,62:21-31 2014 Author:Igarashi K, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Toriyama Y, Tanaka M, Liu T, Xian X, Imai A, Zhai L, Owa S, Arai T, Shindo T.
Calcitonin Gene-related Peptide Is Involved in Inflammatory Pain but Not in Postoperative Pain. Anesthesiology.,121(5):1068-79 2014 Author:Ishida K, Kawamata T, Tanaka S, Shindo T, Kawamata M.
Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection PLoS One,9(2):e87667 2014 Author:Uetake R, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Yoshizawa T, Koyama T, Yang L, Toriyama Y, Yamauchi A, Igarashi K, Tanaka M, Kuwabara T, Mori K, Yanagita M, Mukoyama M, Shindo T.
A single blastocyst assay optimized for detecting CRISPR/Cas9 system-induced indel mutations in mice. BMC Biotechnol.,14(1):69 2014 Author:Sakurai T, Watanabe S, Kamiyoshi A, Sato M, Shindo T.
Regulation of adrenomedullin and its family peptide by RAMP system Curr Prot Pept Sci.,14(5):347-367 2013 Author:Shindo T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Shimoyama N, Iinuma N, Arai T, Miyagawa S.
Endogenous CGRP protects against neointimal hyperplasia following wire-induced vascular injury J Mol Cell Cardiol.,59:55-66 2013 Author:Yang L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yoshizawa T, Koyama T, Iesato Y, Uetake R, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Shindo T.
Adrenomedullin-RAMP2 system is crucially involved in retinal angiogenesis Am J Pathol.,182(6):2380-2390 2013 Author:Iesato Y, Toriyama Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yoshizawa T, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Igarashi K, Murata T, Shindo T
Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-RAMP2 system Hypertension,61(2):341-351 2013 Author:Yoshizawa T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Nakada T, Kashihara T, Yamada M, Kawakami H, Nakanishi H, Taguchi R, Nakanishi T, Akazawa H, Shindo T.
Vascular endothelial adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis Circulation,127(7):842-853 2013 Author:Koyama T, Ochoa-Callejero L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Iinuma N, Arai T, Yoshizawa T, Iesato Y, Lei Y, Uetake R, Okimura A, Yamauchi A, Tanaka M, Igarashi K, Toriyama Y, Kawate H, Adams R.H, Kawakami H, Mochizuki N, Martínez A, Shindo T
Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding. Protein Sci.,21:199-210 2012 Author:Kusano S, Kukimoto-Niino M, Hino N, Ohsawa N, Okuda K, Sakamoto K, Shirouzu M, Shindo T, Yokoyama S.
Adrenomedullin-RAMP2 system in cardiovascular development and homeostasis Curr Hypertens Rev.,7(4):217-227 2011 Author:Shindo T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y.
Induction of LYVE-1/stabilin-2-positive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling Peptides,32(9):1855-1865 2011 Author:Arai T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Iinuma N, Iesato Y, Koyama T, Yoshizawa T, Uetake R, Yamauchi A, Yang L, Kawate H, Ogawa S, Kobayashi A, Miyagawa S, Shindo T.
Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload. J Clin Invest.,120(1):254-65 2010 Author:Takeda N, Manabe I, Uchino Y, Eguchi K, Matsumoto S, Nishimura S, Shindo T, Nagai R.
From Bench to Bedside アドレノメデュリンと血管新生 Vascular Medicine,5(1):71-6 2009 Author:新藤隆行
Regulation of angiogenesis and vascular integrity by adrenomedullin-RAMP2 system. J Soc Circ Res.,32(2):33-35 2009 Author:Shindo Y, Sakurai T, Kamiyoshi A, Koyma T, Yoshizawa T, Shindo T.
Endogenous a-CGRP mitigates liver fibrosis in chronic hepatitis induced by repeated administration of concanavalin A. Liver International.,29(5):642-9 2009 Author:Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y. Iinuma N, Kawate H, Yoshizawa T, Koyama T, Muto S, Shindo T.
転写因子KLF5と血管リモデリング Bio Clinica,21(7):643-7 2008 Author:新藤隆行
Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9.: Shinoda Y, Ogata N, J Biol Chem.,283(36):24682-9 2008 Author:Higashikawa A, Manabe I,Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, Kawaguchi H.
Crystal structure of the human receptor activity-modifying protein 1 extracellular domain Protein Sci.,17(11):1907-14 2008 Author:Kusano S, Kukimoto-Niino M, Akasaka R, Toyama M, Terada T, Shirouzu M, ShindoT, Yokoyama S.
Rapid zygosity determination in mice by SYBR Green real-time genomic PCR of a crude DNA solution. Transgenic Res.,17:149-55 2008 Author:Sakurai T, Kamiyoshi A, Watanabe S, Sato M, Shindo T.
GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity. J Clin Invest.,(118):29-39 2008 Author:Ichikawa-Shindo Y, Sakurai T, Kamiyoshi A, Kawate H, Iinuma N, Yoshizawa T, Koyama T, Fukuchi J, Iimuro S, Moriyama N, Kawakami H, Murata T, Kangawa K, Nagai R, Shindo T.
Adrenomedullin insufficiency increases allergen-induced airway hyperresponsiveness in mice. J Appl Physiol.,102(6):2361-8 2007 Author:Yamamoto H, Nagase T, Shindo T, Teramoto S, Aoki-Nagase T, Yamaguchi Y, Hanaoka Y, Kurihara H, Ouchi Y
Endogenous alpha CGRP protects against concanavalin A-induced hepatitis in mice BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,343(1):152-158 2006 Author:Kainiyoshi, A; Sakurai, T; Ichikawa-Shindo, Y; Fukuchi, J; Kawate, H; Muto, S; Tagawa, Y; Shindo, T
The synthetic retinoid Am80 reduces scavenger receptor expression and atherosclerosis in mice by inhibiting IL-6 ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,26(5):1177-1183 2006 Author:Takeda, N; Manabe, I; Shindo, T; Iwata, H; Iimuro, S; Kagechika, H; Shudo, K; Nagai, R
Azelnidipine, a long-acting dihydropyridine calcium channel blocker, suppresses the development of cardiac hypertrophy and fibrosis in adrenomedullin knock out mice. CIRCULATION,114(18):13-13 2006 Author:Shindo, T; Niu, P; Kamiyoshi, A; Sakurai, T; Ichikawa, Y; Iinuma, N; Kawate, H
転写因子KLF5を標的とした再狭窄治療の開発 The Circulation Frontier,97:201-26 2005 Author:新藤隆行
Kruppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation Cell Metabolism,1:27-29 2005 Author:Oishi Y, Manabe I, Tobe K, Tsushima K, Shindo T, Fujiu K, Nishimura G, Maemura K, Yamauchi T, Kubota N, Suzuki R, Kitamura T, Akira S, Kadowaki T, Nagai R
Synthetic Retinoid Am80 Suppresses Smooth Muscle Phenotypic Modulation and In-Stent Neointima Formation by Inhibiting KLF5 Circ Res,97:1132-1141 2005 Author:Fujiu K, Manabe I, Ishihara A, Oishi Y, Iwata H, Nishimura G, Shindo T, Maemura K, Kagechika H, Shudo K, Nagai R
Significance of the transcription factor KLF5 in cardiovascular remodeling J ThrombHaemost,343:1569-1576 2005 Author:Nagai R, Suzuki T, Aizawa K, Shindo T, Manabe I
細胞生物学講座 転写因子KLF5による心血管リモデリング 細胞 2004 Author:新藤隆行
Unique roles of G protein-coupled histamine H2 and gastrin receptors in growth and differentiation of gastric mucosa Eur J Pharmacol,502:243-252 2004 Author:Fukushima Y, Matsui T, Saitoh T, Ichinose M, Tateishi K, Shindo T, Fujishiro M, Sakoda H, Shojima N, Kushiyama A, Fukuda S, Anai M, Ono H, Oka M, Shimizu Y, Kurihara H, Nagai R, Ishikawa T, Asano T, Omata M
Angiogenic effects of adrenomedullin in ischemia and tumor growth Circ Res,95:415-423 2004 Author:Iimuro S, Shindo T, Moriyama N, Amaki T, Niu P, Takeda N, Iwata H, Zhang Y, Ebihara A, Nagai R
Protective effects of endogenous adrenomedullin on cardiac hypertrophy, fibrosis and renal damage Circulation,109:1789-1794 2004 Author:Niu P, Shindo T, Iwata H, Iimuro S, Takeda N, Zhang Y, Ebihara A, Suematsu Y, Kangawa K, Hirata Y, Nagai R
Endothelial responses of the aorta from adrenomedullin transgenic mice and knockout mice. Hypertens Res,26:S79-84 2003 Author:Nishimatsu H, Hirata Y, Shindo T, Kurihara H, Suzuki E, Sata M, Satonaka H, Takeda R, Nagata D, Kakoki M, Hayakawa H, Kangawa K, Matsuo H, Kitamura T, Nagai R
Targeted disruption of adrenomedullin and alphaCGRP genes reveals their distinct biological roles. Hypertens Res,26:S105-8 2003 Author:Kurihara H, Shindo T, Oh-Hashi Y, Kurihar Y, Kuwaki T
Structural and functional characterization of gastric mucosa and central nervous system in histamine H(2) receptor-null mice. Eur J Pharmacol,468(1):47-58 2003 Author:Fukushima Y, Shindo T, Anai M, Saitoh T, Wang Y, Fujishiro M, Ohashi Y, Ogihara T, Inukai K, Ono H, Sakoda H, Kurihara Y, Honda M, Shojima N, Fukushima H, Haraikawa-Onishi Y, Katagiri H, Shimizu Y, Ichinose M, Ishikawa T, Omata M, Nagai R, Kurihara H, Asano T
Accelerated cardiac hypertrophy and renal damage induced by angiotensin II in adrenomedullin knockout mice. Hypertens Res,26:731-736 2003 Author:Niu P, Shindo T, Iwata H, Ebihara A, Suematsu Y, Zhang Y, Takeda N, Iimuro S, Hirata Y, Nagai R
KLF5/BTEB2, a Kruppel-like zinc-finger type transcription factor, mediates both smooth muscle cell activation and cardiac hypertrophy. Adv Exp Med Biol,538:57-65 2003 Author:Nagai R, Shindo T, Manabe I, Suzuki T, Kurabayashi M
Renal damage and salt-dependent hypertension in aged transgenic mice overexpressing endothelin-1. J. Mol. Med,80(2):105-16 2002 Author:Shindo T, Kurihara H, MaemuraK, Kurihara Y, Ueda O, Suzuki H, Kuwaki T, Ju K-H, Wang Y, Ebihara A, Nishimatsu H, Moriyama N, Fukuda M, Akimoto Y, Hirano H, Morita H, Kumada M, Yazaki Y, Nagai R, Kimura K
Role of endogenous adrenomedullin in the regulation of vascular tone and ischemic renal injury. Studies on transgenic/knockout mice of adrenomedullin gene. Circ Res,90:657-63 2002 Author:Nishimatsu H, Hirata Y, Shindo T, Kurihara H, Kakoki M, Nagata D, Hayakawa H, Satonaka H, Sata M, Tojo A, Suzuki E, Kangawa K, Matsuo H, Kitamura T, Nagai R
Regulation of angiogenesis by the aging suppressor gene klotho. Biochem Biophys Res Commun,293:332-7 2002 Author:Fukino K, Suzuki T, Saito Y, Shindo T, Amaki T, Kurabayashi M, Nagai R
Resistance to neointimal hyperplasia and fatty streak formation in adrenomedullin overexpression mice. Arterioscler Thromb Vasc Biol,22(8):1310-5 2002 Author:Imai Y, Shindo T, Maemura K, Sata M, Saito Y, Kurihara Y, Akishita M, Osuga J, Ishibashi S, Tobe K, Morita H, Oh-hashi Y, Suzuki T, Maekawa H, Kangawa K, Minamino N, Yazaki Y, Nagai R, Kurihara H
Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nature Medicine,8(8):856-63 2002 Author:Shindo T, Manabe I, Fukushima Y, Tobe K, Aizawa K, Miyamoto S, Kawai-Kowase K, Moriyama N, Imai Y, Kawakami H, Nishimatsu H, Suzuki T, Morita H, Maemura K, Sata M, Komukai M, Kagechika H, Kadowaki T, Kurabayashi M, Nagai R
Attenuation of antigen-induced airway hyperresponsiveness in CGRP-deficient mice. Am J Physiol Lung Cell Mol Physiol,283(5):L963-70 2002 Author:Aoki-Nagase T, Nagase T, Oh-Hashi Y, Shindo T, Kurihara Y, Yamaguchi Y, Yamamoto H, Tomita T, Ohga E, Nagai R, Kurihara H, Ouchi Y
A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 null mutant mice develop renal lesions mimicking obstructive nephropathy. Nephrol Dial Transplant,17:39-41 2002 Author:Yokoyama H, Wada T, Kobayashi K, Kuno K, Kurihara H, Shindo T, Matsushima K
Protective effect of adrenomedullin against cardiac hypertrophy and renal damage. J Cardiac Failure,8:S221 2002 Author:Niu P, Shindo T, Ebihara A, Zhang Y, Kawanami D, Imai Y, Amaki T, Suematsu Y, Nagai R
Gene expression in fibroblasts and fibrosis. Involvement in cardiac hypertrophy. Circ Res,27:1103-1113 2002 Author:Gene expression in fibroblasts and fibrosis. Involvement in cardiac hypertrophy.
Diet-induced hyperhomocysteinemia exacerbates neointima formation in rat carotid arteries after balloon injury. Circulation,103(1):133-9 2001 Author:Morita H, Kurihara H, Yoshida S, Saito Y, Shindo T, Oh-Hashi Y, Kurihara Y, Yazaki Y, Nagai R
Vascular smooth muscle cell-directed overexpression of heme oxygenase-1 elevates blood pressure through attenuation of nitric oxide-induced vasodilation in mice. Circ Res,89(1):55-62 2001 Author:Imai T, Morita T, Shindo T, Nagai R, Yazaki Y, Kurihara H, Suematsu M, Katayama S
Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene. Circulation,104:1964-71 2001 Author:Shindo T, Kurihara Y, Nishimatsu H, Moriyama N, Kakoki M, Wang Y, Imai Y, Ebihara A, Kuwaki T, Ju K-H, Minamino N, Kangawa K, Ishikawa T, Fukuda M, Akimoto Y, Kawakami H, Imai T, Morita H, Yazaki Y, Nagai R, Hirata H, Kurihara H
Elevated sympathetic nervous activity in mice deficient in aCGRP. Circ Res,89:983-90 2001 Author:Oh-hashi Y,* Shindo T* (*double 1st author), Kurihara Y, Imai T, Wang Y, Morita H, Imai Y, Kayaba Y, Nishimatsu H, Suematsu Y, Hirata Y, Yazaki Y, Nagai R, Kuwaki T, Kurihara H
Evidence for the physiological and pathological roles of adrenomedullin from genetic engineering in mice. Ann N Y Acad Sci,947:26-33 2001 Author:Imai Y, Shindo T, Maemura K, Kurihara Y, Ryozo N, Kurihara H
Evidence for association between paraoxonase gene polymorphisms and atherosclerotic diseases. Atherosclerosis,149(2):435-42 2000 Author:Imai Y, Morita H, Kurihara H, Sugiyama T, Kato N, Ebihara A, Hamada C, Kurihara Y, Shindo T, Oh-hashi Y, Yazaki Y
Hypotension and resistance to lipopolysaccharide-induced shock in transgenic mice overexpressing Circulation,101(19):2309-16 2000 Author:Shindo T, Kurihara H, Maemura K, Kurihara Y, Kuwaki T, Izumida T, Minamino N, Ju K, Morita H, Oh-hashi Y, Kumada M, Kangawa K, Nagai R, Yazaki Y
ADAMTS-1: A metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphologyand function. J Clin Invest,105(10):1345-52 2000 Author:Shindo T, Kurihara H, Kuno K, Yokoyama H, Wada T, Kurihara Y, Imai T, WangY, Oh-hashi Y, Morita H, Ishikawa T, Yazaki Y, Matsushima K
Polymorphism of the methionine synthase gene : association with homocysteine metabolism and late-onset vascular diseases in the Japanese population. Arterioscler Thromb Vasc Biol,19(2):298-302 1999 Author:Morita H, Kurihara H, Sugiyama T, Hamada C, Kurihara Y, Shindo T, Oh-hashi Y, Yazaki Y
Responses of blood pressure and catecholamine metabolism to high salt loading in endothelin-1 knockout mice. Hypertens Res,22(1):11-6 1999 Author:Morita H, Kurihara H, Kurihara Y, Kuwaki T, Shindo T, Oh-hashi Y, Kumada M, Yazaki Y
Methylenetetrahydrofolate reductase gene polymorphism and ischemic stroke in Japanese. Arterioscler Thromb Vasc Biol,18(9):1465-9 1998 Author:Morita H, Kurihara H, Tsubaki S, Sugiyama T, Hamada C, Kurihara Y, Shindo T, Oh-hashi Y, Kitamura K, Yazaki Y
Systemic and renal response to salt loading in endothelin-1 knockout mice. J Cardiovasc Pharmacol,(31):S557-60 1998 Author:Morita H, Kurihara H, Kurihara Y, Shindo T, Kuwaki T, Kumada M, Yazaki Y
Cardiac sarcoidosis. Circulation,97(13):1306-7 1998 Author:Shindo T, Kurihara H, Ohishi N, Morita H, Maemua K, Kurihara Y, Tsuneyoshi H, Chi H, Yamaoki K, Yazaki Y
Upregulation of endothelin-1 and adrenomedullin gene expression in the mouse endotoxin shock model. J Cardiovasc Pharmacol,31:S541-4 1998 Author:Shindo T, Kurihara H, Kurihara Y, Morita H, Yazaki Y
Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) as a risk factor forcoronary artery disease. Circulation,95(8):2032-6 1997 Author:Morita H, Taguchi J, Kurihara H, Kitaoka M, Kaneda H, Kurihara Y, Maemura K, Shindo T, Minamino T, Ohno M, Yamaoki K, Ogasawara K, Aizawa T, Suzuki S, Yazaki Y
Nitric oxide synthesis in cardiac myocytes and fibroblasts by inflammatory cytokines. Cardiovasc Res,29(6):813-9 1995 Author:Shindo T, Ikeda U, Ohkawa F, Kawahara Y, Yokoyama M, Shimada K
Nitric oxide synthesis in rat cardiac myocytes and fibroblasts. Life Sci.,55(14):1101-8 1994 Author:Shindo T, Ikeda U, Ohkawa F, Takahashi M, Funayama H, Nishinaga M, Kawahara Y, Yokoyama M, Kasahara T, Shimada K
Investigation of the therapeutic effect of adrenomedullin on experimental autoimmune uveitis. The Association for Research in Vision and Ophthalmology (ARVO) 2023 2023(Apr. 23) Presenter:Matsuda Y, Kakihara S, Hirabayashi K, Imai A, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Tanaka M, Kawate H, Zhao Y, Murata T, Shindo T
Role of adrenomedullin-2/intermedin in the pathogenesis of neovascular AMD. FujiRetina2023 2023(Mar. 25) Presenter:Kakihara S, Matsuda Y, Hirabayashi K, Imai A, Iesato Y, Sakurai T, Kamiyoshi A, Tanaka M, Ichikawa-Shindo Y, Kawate H, Zhao Y, Murata T, Shindo T
Vascular homeostatic function of the AM-RAMP2 system and its application to the regulation of lymph node metastasis. 第87回日本循環器学会 2023(Mar. 10) Presenter:Tanaka M, Sakurai T, Kamiyoshi K, Ichikawa-Shindo Y, Kawate H, Kakihara S, Zhao Y, Matsuda Y, Zhang Y, Guo Q, Li P, Onishi N, Kasahara T, Shindo T.
Adrenomedullin-2/intermedin ameliorates pathological angiogenesis and associated inflammation and fibrotic lesions via Meox2. 第87回日本循環器学会 2023(Mar. 10) Presenter:Kakihara S, Matsuda Y, Sakurai T, Kamiyoshi K, Tanaka M, Ichikawa-Shindo Y, Kawate H, Zhao Y, Zhang Y, Guo Q, Li P, Onishi N, Kasahara T, Shindo T.
Endogenous adrenomedullin 2 /intermedin exerts cardioprotective effects against pressure overload. 第87回日本循環器学会 2023(Mar. 10) Presenter:Zhao Y, Sakurai T, Kamiyoshi K, Ichikawa-Shindo Y, Kawate H, Tanaka M, Kakihara S, Matsuda Y, Zhang Y, Guo Q, Li P, Onishi N, Kasahara T, Shindo T.
Role of adrenomedullin-2/intermedin in the pathogenesis of neovascular age-related macular degeneration 第26回日本心血管内分泌代謝学会 2023(Feb. 08) Presenter:Kakihara S, Matsuda Y, Hirabayashi K, Imai A, Iesato Y, Sakurai T, Kamiyoshi A, Tanaka M, Ichikawa-Shindo Y, Kawate H, Zhao Y, Zhang Y, Guo Q, Li P, Onishi N, Murata T, Shindo T
Adrenomedullin-2 ameliorates neovascular AMD via the upregulation of Meox2 第61回日本網膜硝子体学会 2022(Dec. 02) Presenter:Kakihara S, Matsuda Y, Hirabayashi K, Imai A, Iesato Y, Sakurai T, Kamiyoshi A, Tanaka M, Ichikawa-Shindo Y, Kawate H, Murata T, Shindo T
圧ストレス応答におけるアドレノメデュリン2の心保護作用 第26回日本心血管内分泌代謝学会 2022(Oct. 12) Presenter:Zhao Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Tanaka M, Kawate H, Kakihara S, Matsuda Y,Zhang Y, Shindo T
Investigation of the therapeutic effect of adrenomedullin on experimental autoimmune uveitis. The Association for Research in Vision and Ophthalmology (ARVO) 2022 2022(May 14) Presenter:Matsuda Y, Kakihara S, Hirabayashi K, Imai A, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo, Y, Tanaka M, Kawate H, Zhao Y, Murata T, Shindo T.
Transcriptome analysis of the pathophysiological significance of adrenomedullin 2 in the mouse choroidal neovascularization model. The Association for Research in Vision and Ophthalmology (ARVO) 2022 2022(May 14) Presenter:Kakihara K, Sakurai T, Kamiyoshi A, Tanaka M, Kawate H, Ichikawa-Shindo Y, Zhao Y, Matsuda Y, Hirabayashi K, Imai A, Iesato Y, Murata T, Shindo T.
Homeostatic Regulation of High Endothelial Venules and Suppression of Lymphatic Metastasis by Adrenomedullin-RAMP2 System 第86回日本循環器学会 2022(Mar. 11) Presenter:Tanaka M, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Hisaka K, Kakihara S, Zhao Y, Matsuda Y, Aruga K, Kasahara T, Shindo T.
Elucidation of the Significance of the Adrenomedullin-RAMP System as a Novel Therapeutic Target for Sarcopenia 第86回日本循環器学会 2022(Mar. 11) Presenter:Aruga K, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Hisaka K, Tanaka M, Kakihara S, Zhao Y, Matsuda Y, Kasahara T, Shindo T.
Pathophysiological Significance of Adrenomedullin 2 in Hepatic and Metabolic Regulation 第86回日本循環器学会 2022(Mar. 11) Presenter:Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Hisaka K, Tanaka M, Kakihara S, Zhao Y, Matsuda Y, Aruga K, Kasahara T, Shindo T.
Pathophysiological roles of adrenomedullin-2 in mouse model of ocular neovascularization. The Association for Research in Vision and Ophthalmology (ARVO) 2021 2021(May 01) Presenter:Kakihara S, Tanaka M, Hirabayash K, Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A, Kawate H, Ichikawa-Shindo Y, Tanaka M, Murata T, Shindo T.
Adrenomedullin-RAMP2 system ameliorates age-related macular degeneration by suppressing choroidal neovascularization and subretinal fibrosis 第85回日本循環器学会 2021(Mar. 26) Presenter:Tanaka M, Kakihara S, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Cui N, Wei Y, Zhao Y, Kasahara T, Aruga K, Shindo T
Adrenomedullin-RAMP2 and -RAMP3 systems regulate cardiac homeostasis during cardiovascular stress 第85回日本循環器学会 2021(Mar. 26) Presenter:Cui N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Wei Y, Tanaka M, Kakihara S, Zhao Y, Kasahara T, Aruga K, Shindo T
Adrenomedullin-RAMP2 system regulates vascular endothelial homeostasis, which suppresses hematogenous and lymphogenous metastasis 第85回日本循環器学会 2021(Mar. 26) Presenter:Tanaka M, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Cui N, Wei Y, Tanaka M, Kakihara S, Zhao Y, Kasahara T, Aruga K, Shindo T
Adrenomedullin-RAMP2 system regulates high endothelial venules in lymph nodes and suppresses lymphatic metastasis 第28回日本血管生物医学会 2021(Mar. 12) Presenter:Tanaka M, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Cui N, Wei Y, Zhao Y, Aruga K, Shindo T
Intermedin/Adrenomedullin 2 deficiency causes obesity and liver dysfunction under high-fat diet 第24回日本心血管内分泌代謝学会 2021(Mar. 12) Presenter:Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Tanaka M, Cui N, Wei Y, Zhao Y, Aruga K, Shindo T
Adrenomedullin-RAMP2 and -RAMP3 systems regulate cardiac homeostasis during cardiovascular stress 第24回日本心血管内分泌代謝学会 2021(Mar. 12) Presenter:Cui N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Wei Y, Zhao Y, Aruga K, Shindo T
Adrenomedullin-RAMP2 system ameliorates pulmonary fibrosis by regulating TGF-β-Smads pathway and differentiation of myofibroblasts 第24回日本心血管内分泌代謝学会 2021(Mar. 12) Presenter:Wei Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Cui N, Zhao Y, Aruga K, Shindo T
Adrenomedullin-RAMP2 system ameliorates subretinal fibrosis in age-related macular degeneration by suppressing epithelial-mesenchymal transition mediated via TGF-β-ROCK1-CXCR4 pathway 第24回日本心血管内分泌代謝学会 2021(Mar. 12) Presenter:Tanaka M, Kakihara S, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Yamauchi A, Murata T, Shindo T
Blockade of the adrenomedullin-RAMP3 system suppresses metastasis through modification of cancer-associated fibroblasts. 第84回日本循環器学会 2020(Jul. 27) Presenter:Dai K, Tanaka M, Sakurai T, Kamiyoshi A, Shindo Y, Kawate H, Cui N, Wei Y, Tanaka M, Kakihara S, Matsui S, Shindo T.
Adrenomedullin-RAMP2 and RAMP3 systems regulate cardiac homeostasis against cardiovascular stresses Asian Pacific Society of Cardiology Congress 2020 (APSC2020) 2020(Jul. 27) Presenter:Cui N, Sakurai T, Kamiyoshi A, Shindo Y, Kawate H, Tanaka M, Dai K, Wei Y, Tanaka M. Kakihara S, Matsui S, Shindo T.
Deficiency of the adrenomedullin-RAMP3 system suppresses cancer metastasis through modification of cancer-associated fibroblasts (CAF) 第23回日本心血管内分泌代謝学会 2019(Dec. 14) Presenter:戴昆、田中愛、神吉昭子、桜井敬之、新藤優佳、河手久香、崔南奇、魏陽璇、新藤隆行
Loss of adrenomedullin-RAMP3 system suppresses inter-organ metastasis by regulation of podoplanin (PDPN) expression in cancer-associated fibroblasts (CAFs) 日本癌学会 2019(Sep. 26) Presenter:Dai K, Tanaka M, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Cui N, Wei Y, Matsui S, Nakamura K, Kakihara S, Yamauchi A, Shindo T.
Development of a retinal vascular occlusion model in mice and analysis of the pathophysiological roles of adrenomedullin Congress of Asia-Pacific Academy of Ophthalmology 2019(Mar. 06) Presenter:Kazutaka Hirabayashi, Toshinori Murata, Takayuki Shindo, Masaaki Tanaka, Akira Imai
Suppression of tumor metastasis through targeting the vascular integrity regulated by AM-RAMP2 system 日本癌学会 2018(Sep. 27) Presenter:田中愛、桜井敬之、神吉昭子、新藤優佳、河手久香、平林一貴、戴昆、崔南奇、Wei Yangxuan、田中正明、冨山遥、山内啓弘、新藤隆行
Vascular homeostasis regulated by adrenomedullin-RAMP2 system and its application for diabetic vascular complications 日本糖尿病学会 2018(May 24) Presenter:新藤隆行
Investigation of the therapeutic effect of adrenomedullin on central retinal vein occlusion The Association for Research in Vision and Ophthalmology 2018(Apr. 28) Presenter:Kazukata Hirabayashi, Toshinori Murata, Yasuhiro Iesato, Akira Imai, Yuichi Toriyama, Masaaki Tnanaka, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Megumu Tanaka, Akihiro Yamauchi, Takayuki Shindo
Endogenous calcitonin gene-related peptide (CGRP) suppresses ischemic brain injuries and progression of cognitive decline 第82回日本循環器学会 2018(Mar. 24) Presenter:Zhai L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Hirabayashi K, Dai K, Cui N, Wei Y, Tanaka M, Tanimura K, Liu T, Tomiyama H, Matsui S, Yamauchi A, Shindo T.
Pathophysiological significance of adrenomedullin-RAMP2 system in cardiac myocytes. 第82回日本循環器学会 2018(Mar. 24) Presenter:Zhai L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Hirabayashi K, Dai K, Cui N, Wei Y, Tanaka M, Tanimura K, Liu T, Tomiyama H, Matsui S, Yamauchi A, Shindo T.
Regulation of cytoskeleton and energy metabolism of adipocytes by adrenomedullin-RAMP2 system 第82回日本循環器学会 2018(Mar. 24) Presenter:Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Tanaka M, Zhai L, Hirabayashi K, Dai K, Cui N, Wei Y, Tanaka M, Tanimura K, Liu T, Tomiyama H, Matsui S, Yamauchi A, Shindo T.
Novel mouse model of CRVO by intraperitoneal injection of Rose Bengal with laser radiation The Association for Research in Vision and Ophthalmology 2017 2017(May 07) Presenter:Hirabayashi K, Imai A, Iesato Y, Toriyama Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Yamauchi A, Murata T, Shindo T.
Adrenomedullin-RAMP2 system inhibits the endothelial to mesenchymal transition (EndMT) and formation of pre-metastatic niche by maintaining vascular integrity 第33回国際心臓研究学会 2016(Dec. 16) Presenter:Tanaka M, Sakurai T, Kamiyoshi A, Shindo T.
Adrenomedullin-RAMP2 system inhibits the endothelial-mesenchymal transition and formation of pre-metastatic niche by maintaining vascular integrity 第24回日本血管生物医学会 2016(Dec. 08) Presenter:Tanaka M, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Imai A, Zhai L, Hirabayashi K, Dai K, Cui N, Liu T, Tanimura K, Wei Y, Yamauchi A, Shindo T.
Vascular adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis The 10th World Congress for Microcirculation シンポジウム招待講演 2015(Sep. 24) Presenter:Shindo T.
Vascular endothelial adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis The Conference on Bioactive Peptides for Cell-Cell Communication 2014 Symposium 2014(Sep. 11) Presenter:Shindo T.
Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling 2003 Presenter:新藤隆行
転写因子BTEB2/KLF5による心血管リモデリング制御 2002 Presenter:新藤隆行
マウス遺伝子操作によるアドレノメデュリンの機能解析 2001 Presenter:新藤隆行
マウス遺伝子操作によるアドレノメデュリンの機能解析 2001 Presenter:新藤隆行
特許等知的財産
登録済特許 RAMP2を標的とする血管構造の安定化剤及び血管新生剤 , JP RAMP2を標的とする血管構造の安定化剤及び血管新生剤 , EP RAMP2を標的とする血管構造の安定化剤及び血管新生剤 , US 代謝症候群の治療もしくは予防剤、検査方法、検査薬、及び代謝症候群の治療薬の候補化合物のスクリーニング方法 , JP 代謝症候群の治療もしくは予防剤、検査方法、検査薬、及び代謝症候群の治療薬の候補化合物のスクリーニング方法 , CN 代謝症候群の治療もしくは予防剤、検査方法、検査薬、及び代謝症候群の治療薬の候補化合物のスクリーニング方法 , US 代謝症候群の治療もしくは予防剤、検査方法、検査薬、及び代謝症候群の治療薬の候補化合物のスクリーニング方法 , EP