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沢村達也  サワムラ タツヤ

教員組織学術研究院(医学系)電話番号
教育組織医学部 医学科 生理学FAX番号
職名教授メールアドレス
住所〒390-8621 長野県松本市旭3-1-1ホームページURL

プロフィール

研究分野
分子病態学
生理学一般
所属学会
所属学会
日本生化学会
日本薬理学会
日本生理学会
日本循環器学会
日本動脈硬化学会
日本循環薬理学会
日本心血管内分泌代謝学会
高血圧関連疾患モデル学会
国際心臓研究学会
学歴
出身大学院
1992 , 筑波大学
受賞学術賞
2016 , 文部科学大臣表彰 科学技術賞(開発部門)
2009 , 日本学術振興会賞
2008 , バイオビジネスコンペJAPAN優秀賞
2008 , 日本心血管内分泌代謝学会 第12回高峰譲吉研究奨励賞
2001 , 日本薬理学会学術奨励賞
2000 , 成人血管病研究振興財団 岡本研究奨励賞
2000 , 日本生化学会奨励賞
研究職歴等
研究職歴
2010-2014 , 独立行政法人国立循環器病研究センター 血管生理学部部長
2003-2010 , 国立循環器病センター 脈管生理部部長
1998-2003 , 国立循環器病センター バイオサイエンス部細胞生物学研究室長
1992-1997 , 京都大学医学部助手
1991-1992 , 学術振興会特別研究員

研究活動業績

研究業績(著書・
発表論文等)
論文
Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo.
Aging Cell,:e12792 2018
Author:Wang, Y.C., Lee, A.S., Lu, L.S., Ke, L.Y., Chen, W.Y., Dong, J.W., Lu, J., Chen, Z., Chu, C.S., Chan, H.C., Kuzan, T.Y., Tsai, M.H., Hsu, W.L., Dixon, R.A.F., Sawamura, T., Chang, K.C. and Chen, C.H.


Ecrg4 peptide is the ligand of multiple scavenger receptors. Sci Rep
Sci Rep,8:4048 2018
Author:Moriguchi, T., Takeda, S., Iwashita, S., Enomoto, K., Sawamura, T., Koshimizu, U. and Kondo, T.


123I-labeled oxLDL is widely distributed throughout the whole body in mice.
Nucl Med Mol Imaging,52:144-153 2018
Author:Nakano, A., Kawashima, H., Miyake, Y., Zeniya, T., Yamamoto, A., Koshino, K., Temma, T., Fukuda, T., Fujita, Y., Kakino, A., Kanaya, S., Sawamura, T. and Iida, H.


Smoking cessation reduces the lectin-like low-density lipoprotein receptor index, an independent cardiovascular risk marker of vascular inflammation.
Heart Vessels,33:9-16 2018
Author:Komiyama, M., Wada, H., Ono, K., Yamakage, H., Satoh-Asahara, N., Shimada, S., Akao, M., Morimoto, T., Shimatsu, A., Takahashi, Y., Sawamura, T. and Hasegawa, K.


Electronegative Low-density Lipoprotein L5 induces adipose tissue inflammation associated with metabolic syndrome.
J Clin Endocrinol Metab,102:4615-4625 2017
Author:Ke, L.Y., Chan, H.C., Chan, H.C., Kalu, F.C.U., Lee, H.C., Lin, I.L., Jhuo, S.J., Lai, W.T., Tsao, C.R., Sawamura, T.


Syncytiotrophoblast extracellular vesicles impair rat uterine vascular function via the lectin-like oxidized LDL receptor-1.
PLoS One,12:e0180364 2017
Author:Spaans, F., Kao, C.K., Morton, J.S., Quon, A.L., Sawamura, T., Tannetta, D.S., Sargent, I.L. and Davidge, S.T.


Developmental endothelial locus-1 (Del-1) inhibits oxidized low-density lipoprotein activity by direct binding, and its overexpression attenuates atherogenesis in mice.
Circ J 2016
Author:Kakino, A., Fujita, Y., Nakano, A., Horiuchi, S. and Sawamura, T.


Lectin-like oxidized low-density lipoprotein receptor (LOX-1) in sickle cell disease vasculopathy.
Blood Cells Mol Dis,60:44-48 2016
Author:Chen, M., Qiu, H., Lin, X., Nam, D., Ogbu-Nwobodo, L., Archibald, H., Joslin, A., Wun, T., Sawamura, T. and Green, R.


Deletion of LOX-1 protects against heart failure induced by doxorubicin.
PLoS One,11:e0154994 2016
Author:Yokoyama, C., Aoyama, T., Ido, T., Kakino, A., Shiraki, T., Tanaka, T., Nishigaki, K., Hasegawa, A., Fujita, Y., Sawamura, T. and Minatoguchi, S.


High levels of soluble lectin-like oxidized low-density lipoprotein receptor-1 in acute stroke: an age- and sex-matched cross-sectional study.
J Atheroscler Thromb,23:1222-1226 2016
Author:Yokota, C., Sawamura, T., Watanabe, M., Kokubo, Y., Fujita, Y., Kakino, A., Nakai, M., Toyoda, K., Miyamoto, Y. and Minematsu, K.


Electronegative low-density lipoprotein increases coronary artery disease risk in uremia patients on maintenance hemodialysis.
Medicine (Baltimore),95:e2265 2016
Author:Chang, C.T., Wang, G.J., Kuo, C.C., Hsieh, J.Y., Lee, A.S., Chang, C.M., Wang, C.C., Shen, M.Y., Huang, C.C., Sawamura, T., Yang, C.Y., Stancel, N. and Chen, C.H.


Lectin-like oxidized low density lipoprotein receptor 1-deficient mice show resistance to instability-induced osteoarthritis.
Scand J Rheumatol,45:412-422 2016
Author:Hashimoto, K., Mori, S., Oda, Y., Nakano, A., Sawamura, T. and Akagi, M.


Serum level of LOX-1 ligand containing ApoB is associated with increased carotid intima-media thickness in Japanese community-dwelling men, especially those with hypercholesterolemiaLOX-1 ligand and IMT in Japanese.
J Clin Lipidol,10:172-180 2016
Author:Okamura, T., Miura, K., Sawamura, T., Kadota, A., Hisamatsu, T., Fujiyoshi, A., Miyamatsu, N., Takashima, N., Miyagawa, N., Kadowaki, T., Ohkubo, T., Murakami, Y., Nakamura, Y., Ueshima, H. and Group, S.R.


Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet aggregation.
Blood,127:1336-1345 2016
Author:Shen, M.Y., Chen, F.Y., Hsu, J.F., Fu, R.H., Chang, C.M., Chang, C.T., Liu, C.H., Wu, J.R., Lee, A.S., Chan, H.C., Sheu, J.R., Lin, S.Z., Shyu, W.C., Sawamura, T., Chang, K.C., Hsu, C.Y. and Chen, C.H.


Increased LDL electronegativity in chronic kidney disease disrupts calcium homeostasis resulting in cardiac dysfunction.
J Mol Cell Cardiol,84:36-44 2015
Author:Chang, K.C., Lee, A.S., Chen, W.Y., Lin, Y.N., Hsu, J.F., Chan, H.C., Chang, C.M., Chang, S.S., Pan, C.C., Sawamura, T., Chang, C.T., Su, M.J. and Chen, C.H.


Cross-talk between LOX-1 and PCSK9 in vascular tissues.
Cardiovasc Res,107:556-567 2015
Author:Ding, Z., Liu, S., Wang, X., Deng, X., Fan, Y., Shahanawaz, J., Shmookler Reis, R.J., Varughese, K.I., Sawamura, T. and Mehta, J.L.


The biphasic effects of oxidized-low density lipoprotein on the vasculogenic function of endothelial progenitor cells.
PLoS One,10:e0123971 2015
Author:Lin, F.Y., Tsao, N.W., Shih, C.M., Lin, Y.W., Yeh, J.S., Chen, J.W., Nakagami, H., Morishita, R., Sawamura, T. and Huang, C.Y.


LOX-1 in atherosclerotic disease.
Clin Chim Acta,440:157-163 2015
Author:Sawamura, T., Wakabayashi, I. and Okamura, T.


The relationship between lectin-like oxidized low-density lipoprotein receptor-1 ligands containing apolipoprotein B and the cardio-ankle vascular index in healthy community inhabitants: The KOBE Study.
J Atheroscler Thromb,22:499-508 2015
Author:Sugiyama, D., Higashiyama, A., Wakabayashi, I., Kubota, Y., Adachi, Y., Hayashibe, A., Kawamura, K., Kuwabara, K., Nishimura, K., Kadota, A., Nishida, Y., Hirata, T., Imano, H., Miyamatsu, N., Miyamoto, Y., Sawamura, T. and Okamura, T.


High-salt in addition to high-fat diet may enhance inflammation and fibrosis in liver steatosis induced by oxidative stress and dyslipidemia in mice.
Lipids Health Dis,14:6 2015
Author:Uetake, Y., Ikeda, H., Irie, R., Tejima, K., Matsui, H., Ogura, S., Wang, H., Mu, S., Hirohama, D., Ando, K., Sawamura, T., Yatomi, Y., Fujita, T. and Shimosawa, T.


Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor.
FASEB J,29:3342-3356 2015
Author:Yamamoto, K., Kakino, A., Takeshita, H., Hayashi, N., Li, L., Nakano, A., Hanasaki-Yamamoto, H., Fujita, Y., Imaizumi, Y., Toyama-Yokoyama, S., Nakama, C., Kawai, T., Takeda, M., Hongyo, K., Oguro, R., Maekawa, Y., Itoh, N., Takami, Y., Onishi, M., Takeya, Y., Sugimoto, K., Kamide, K., Nakagami, H., Ohishi, M., Kurtz, T.W., Sawamura, T. and Rakugi, H.


Human serum amyloid A3 (SAA3) protein, expressed as a fusion protein with SAA2, binds the oxidized low density lipoprotein receptor.
PLoS One,10:e0118835 2015
Author:Tomita, T., Ieguchi, K., Sawamura, T. and Maru, Y.


Lectin-like oxidized low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state.
Bone,75:170-182 2015
Author:Nakayachi, M., Ito, J., Hayashida, C., Ohyama, Y., Kakino, A., Okayasu, M., Sato, T., Ogasawara, T., Kaneda, T., Suda, N., Sawamura, T. and Hakeda, Y.


Effect of sodium tanshinone IIA sulfonate treatment in a rat model of preeclampsia.
Am J Physiol Regul Integr Comp Physiol,308:R163-172 2015
Author:Morton, J.S., Quon, A., Cheung, P.Y., Sawamura, T. and Davidge, S.T.


Increased LDL electronegativity in chronic kidney disease disrupts calcium homeostasis resulting in cardiac dysfunction.
J Mol Cell,84:36-44 2015
Author:Chang, K.C., Lee, A.S., Chen, W.Y., Lin, Y.N., Hsu, J.F., Chan, H.C., Chang, C.M., Chang, S.S., Pan, C.C., Sawamura, T., Chang, C.T., Su, M.J. and Chen, C.H.


Pitavastatin decreases serum LOX-1 ligand levels and MT1-MMP expression in CD14-positive mononuclear cells in hypercholesterolemic patients.
Int J Cardiol,176:1230-1232 2014
Author:Uzui, H., Hayashi, H., Nakae, I., Matsumoto, T., Uenishi, H., Hayasaki, H., Asaji, T., Matsui, S., Miwa, K., Lee, J.D., Tada, H., Sawamura, T. and Fujita, M.


LOX-1 plays an important role in ischemia-induced angiogenesis of limbs.
PLoS One,9:e114542 2014
Author:Shiraki, T., Aoyama, T., Yokoyama, C., Hayakawa, Y., Tanaka, T., Nishigaki, K., Sawamura, T. and Minatoguchi, S.


Significance of soluble lectin-like oxidized LDL receptor-1 levels in systemic and coronary circulation in acute coronary syndrome.
Biomed Res Int,2014:649185 2014
Author:Misaka, T., Suzuki, S., Sakamoto, N., Yamaki, T., Sugimoto, K., Kunii, H., Nakazato, K., Saitoh, S., Sawamura, T., Ishibashi, T. and Takeishi, Y.


Prevention of export of anoxia/reoxygenation injury from ischemic to nonischemic cardiomyocytes via inhibition of endocytosis.
Am J Physiol Heart Circ Physiol,306:H1700-1707 2014
Author:Khaidakov, M., Mercanti, F., Wang, X., Ding, Z., Dai, Y., Romeo, F., Sawamura, T. and Mehta, J.L.


Small dense low-density lipoproteins cholesterol can predict incident cardiovascular disease in an urban Japanese cohort: the Suita study.
J Atheroscler Thromb,20:195-203 2013
Author:Arai, H., Kokubo, Y., Watanabe, M., Sawamura, T., Ito, Y., Minagawa, A., Okamura, T. and Miyamato, Y.


Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation.
Blood,122(22):3632-3641 2013
Author:Chan, H.C., Ke, L.Y., Chu, C.S., Lee, A.S., Shen, M.Y., Cruz, M.A., Hsu, J.F., Cheng, K.H., Chan, H.C., Lu, J., Lai, W.T., Sawamura, T., Sheu, S.H., Yen, J.H. and Chen, C.H.


Electronegative low-density lipoprotein increases C-reactive protein expression in vascular endothelial cells through the LOX-1 receptor.
PLoS One,8:e70533 2013
Author:Chu, C.S., Wang, Y.C., Lu, L.S., Walton, B., Yilmaz, H.R., Huang, R.Y., Sawamura, T., Dixon, R.A., Lai, W.T., Chen, C.H. and Lu, J.


Inhibition of lectin-like oxidized low-density lipoprotein-1 receptor protects against plasma-mediated vascular dysfunction associated with pre-eclampsia.
Am J Hypertens,26:279-286 2013
Author:English, F.A., McCarthy, F.P., McSweeney, C.L., Quon, A.L., Morton, J.S., Sawamura, T., Davidge, S.T. and Kenny, L.C.


LOX-1 ligands containing apolipoprotein B and carotid intima-media thickness in middle-aged community-dwelling US Caucasian and Japanese men.
Atherosclerosis,229:240-245 2013
Author:Okamura, T., Sekikawa, A., Sawamura, T., Kadowaki, T., Barinas-Mitchell, E., Mackey, R.H., Kadota, A., Evans, R.W., Edmundowicz, D., Higashiyama, A., Nakamura, Y., Abbott, R.D., Miura, K., Fujiyoshi, A., Fujita, Y., Murakami, Y., Miyamatsu, N., Kakino, A., Maegawa, H., Murata, K., Horie, M., Mitsunami, K., Kashiwagi, A., Kuller, L.H., Ueshima, H. and Group, E.J.S.


Lectin-like oxidized low-density lipoprotein receptor-1 plays an important role in vascular inflammation in current smokers.
J Atheroscler Thromb,20:585-590 2013
Author:Takanabe-Mori, R., Ono, K., Wada, H., Takaya, T., Ura, S., Yamakage, H., Satoh-Asahara, N., Shimatsu, A., Takahashi, Y., Fujita, M., Fujita, Y., Sawamura, T. and Hasegawa, K.


Oxidized Low Density Lipoprotein (LDL) Affects Hyaluronan Synthesis in Human Aortic Smooth Muscle Cells.
J Biol Chem,288:29595-29603 2013
Author:Viola, M., Bartolini, B., Vigetti, D., Karousou, E., Moretto, P., Deleonibus, S., Sawamura, T., Wight, T.N., Hascall, V.C., De Luca, G. and Passi, A.:


Lectin-like oxidized low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis.
Arthritis Rheum,64:1024-1034 2012
Author:Ishikawa, M., Ito, H., Akiyoshi, M., Kume, N., Yoshitomi, H., Mitsuoka, H., Tanida, S., Murata, K., Shibuya, H., Kasahara, T., Kakino, A., Fujita, Y., Sawamura, T., Yasuda, T. and Nakamura, T.


Lectin-like oxidized low-density lipoprotein 1 receptor in a reduced uteroplacental perfusion pressure rat model of preeclampsia.
Hypertension,59:1014-1020 2012
Author:Morton, J.S., Abdalvand, A., Jiang, Y., Sawamura, T., Uwiera, R.R. and Davidge, S.T.


Dietary cholesterol oxidation products accelerate plaque destabilization and rupture associated with monocyte infiltration/activation via the MCP-1-CCR2 pathway in mouse brachiocephalic arteries: therapeutic effects of ezetimibe.
J Atheroscler Thromb,19:986-998 2012
Author:Sato, K., Nakano, K., Katsuki, S., Matoba, T., Osada, K., Sawamura, T., Sunagawa, K. and Egashira, K.


LOX-1 deletion improves neutrophil responses, enhances bacterial clearance, and reduces lung injury in a murine polymicrobial sepsis model.
Infect Immun,79:2865-2870 2011
Author:Wu, Z., Sawamura, T., Kurdowska, A.K., Ji, H.L., Idell, S. and Fu, J.


Lectin-like oxidized LDL receptor 1 is involved in CRP-mediated complement activation.
Clin Chem,57:1398-1405 2011
Author:Fujita, Y., Yamaguchi, S., Kakino, A., Iwamoto, S., Yoshimoto, R. and Sawamura, T.


An alternative protein standard to measure activity of LOX-1 ligand containing apoB (LAB) - utilization of anti-LOX-1 single- chain antibody fused to apoB fragment.
J Atheroscler Thromb,18:818-828 2011
Author:Iwamoto, S., Fujita, Y., Kakino, A., Yanagida, K., Matsuda, H., Yoshimoto, R. and Sawamura, T.


Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox.
Proc Jpn Acad Ser B Phys Biol Sci,87:104-113 2011
Author:Nishizuka, T., Fujita, Y., Sato, Y., Nakano, A., Kakino, A., Ohshima, S., Kanda, T., Yoshimoto, R. and Sawamura, T.


Associations of atherosclerotic risk factors with oxidized low-density lipoprotein evaluated by LOX-1 ligand activity in healthy men.
Clin Chim Acta,412:1643-1647 2011
Author:Uchida, K., Suehiro, A., Nakanishi, M., Sawamura, T. and Wakabayashi, I.


LOX-1 mediates vascular lipid retention under hypertensive state.
J Hypertens,28:1273-1280 2010
Author:Nakano, A., Inoue, N., Sato, Y., Nishimichi, N., Takikawa, K., Fujita, Y., Kakino, A., Otsui, K., Yamaguchi, S., Matsuda, H. and Sawamura, T.


Oxidized LDL receptor LOX-1 binds to C-reactive protein and mediates its vascular effects.
Clin Chem,55:285-294 2009
Author:Fujita, Y., Kakino, A., Nishimichi, N., Yamaguchi, S., Sato, Y., Machida, S., Cominacini, L., Delneste, Y., Matsuda, H. and Sawamura, T.


A novel gene silencer, pyrrole-imidazole polyamide targeting human lectin-like oxidized low-density lipoprotein receptor-1 gene improves endothelial cell function.
J Hypertens,27:508-516 2009
Author:Ueno, T., Fukuda, N., Tsunemi, A., Yao, E.H., Matsuda, H., Tahira, K., Matsumoto, T., Matsumoto, K., Matsumoto, Y., Nagase, H., Sugiyama, H. and Sawamura, T


Mediation of electronegative low-density lipoprotein signaling by LOX-1: a possible mechanism of endothelial apoptosis.
Circ Res,104:619-627 2009
Author:Lu, J., Yang, J.H., Burns, A.R., Chen, H.H., Tang, D., Walterscheid, J.P., Suzuki, S., Yang, C.Y., Sawamura, T. and Chen, C.H.