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沢村達也  サワムラ タツヤ

教員組織学術研究院(医学系)電話番号
教育組織先鋭領域融合研究群 バイオメディカル研究所 ライフイノベーション部門FAX番号
職名教授メールアドレス
住所〒390-8621 長野県松本市旭3-1-1ホームページURLhttp://goo.gl/sgZ88p

更新日:2019/10/16

プロフィール

兼担研究科・学部
医学部 医学科 分子病態学
研究分野
分子病態学
生理学一般
所属学会
所属学会
日本生化学会
日本薬理学会
日本生理学会
日本循環器学会
日本動脈硬化学会
日本循環薬理学会
日本心血管内分泌代謝学会
高血圧関連疾患モデル学会
国際心臓研究学会
学歴
出身大学院
1992 , 筑波大学

取得学位
医学博士 , 筑波大学大学院
受賞学術賞
2016 , 文部科学大臣表彰 科学技術賞(開発部門)
2009 , 日本学術振興会賞
2008 , バイオビジネスコンペJAPAN優秀賞
2008 , 日本心血管内分泌代謝学会 第12回高峰譲吉研究奨励賞
2001 , 日本薬理学会学術奨励賞
2000 , 成人血管病研究振興財団 岡本研究奨励賞
2000 , 日本生化学会奨励賞
研究職歴等
研究職歴
2010-2014 , 独立行政法人国立循環器病研究センター 血管生理学部部長
2003-2010 , 国立循環器病センター 脈管生理部部長
1998-2003 , 国立循環器病センター バイオサイエンス部細胞生物学研究室長
1992-1997 , 京都大学医学部助手
1991-1992 , 学術振興会特別研究員

研究活動業績

研究業績(著書・
発表論文等)
論文
Dysfunctional high density lipoprotein failed to rescue the function of oxidized low density lipoprotein-treated endothelial progenitor cells: a novel index for the prediction of HDL functionality.
Transl Res,205:17-32 2019
Author:Shih, C.M., Lin, F.Y., Yeh, J.S., Lin, Y.W., Loh, S.H., Tsao, N.W., Nakagami, H., Morishita, R., Sawamura, T., Li, C.Y., Lin, C.Y. and Huang, C.Y.


A novel cell-free, non-fluorescent method to measure Lox-1- binding activity corresponding to the functional activity of HDL.
J Atheroscler Thromb 2019
Author:Kakino, A., Usami, Y., Horiuchi, S., Fujita, Y., Kotani, K., Chen, C.H., Okamura, T. and Sawamura, T.


Targeting LOX-1 in atherosclerosis and vasculopathy: current knowledge and future perspectives.
Ann N Y Acad Sci,1443:34-53 2019
Author:Tian, K., Ogura, S., Little, P.J., Xu, S.W. and Sawamura, T.


Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo.
Aging Cell,:e12792 2018
Author:Wang, Y.C., Lee, A.S., Lu, L.S., Ke, L.Y., Chen, W.Y., Dong, J.W., Lu, J., Chen, Z., Chu, C.S., Chan, H.C., Kuzan, T.Y., Tsai, M.H., Hsu, W.L., Dixon, R.A.F., Sawamura, T., Chang, K.C. and Chen, C.H.


Ecrg4 peptide is the ligand of multiple scavenger receptors. Sci Rep
Sci Rep,8:4048 2018
Author:Moriguchi, T., Takeda, S., Iwashita, S., Enomoto, K., Sawamura, T., Koshimizu, U. and Kondo, T.


123I-labeled oxLDL is widely distributed throughout the whole body in mice.
Nucl Med Mol Imaging,52:144-153 2018
Author:Nakano, A., Kawashima, H., Miyake, Y., Zeniya, T., Yamamoto, A., Koshino, K., Temma, T., Fukuda, T., Fujita, Y., Kakino, A., Kanaya, S., Sawamura, T. and Iida, H.


Smoking cessation reduces the lectin-like low-density lipoprotein receptor index, an independent cardiovascular risk marker of vascular inflammation.
Heart Vessels,33:9-16 2018
Author:Komiyama, M., Wada, H., Ono, K., Yamakage, H., Satoh-Asahara, N., Shimada, S., Akao, M., Morimoto, T., Shimatsu, A., Takahashi, Y., Sawamura, T. and Hasegawa, K.


Alterations in vascular function by syncytiotrophoblast extracellular vesicles via lectin-like oxidized low-density lipoprotein receptor-1 in mouse uterine arteries.
Clin Sci (Lond),132:2369-2381 2018
Author:Spaans, F., Quon, A., Rowe, S.R., Morton, J.S., Kirschenman, R., Sawamura, T., Tannetta, D.S., Sargent, I.L. and Davidge, S.T.


Electronegative Low-density Lipoprotein L5 induces adipose tissue inflammation associated with metabolic syndrome.
J Clin Endocrinol Metab,102:4615-4625 2017
Author:Ke, L.Y., Chan, H.C., Chan, H.C., Kalu, F.C.U., Lee, H.C., Lin, I.L., Jhuo, S.J., Lai, W.T., Tsao, C.R., Sawamura, T.


Syncytiotrophoblast extracellular vesicles impair rat uterine vascular function via the lectin-like oxidized LDL receptor-1.
PLoS One,12:e0180364 2017
Author:Spaans, F., Kao, C.K., Morton, J.S., Quon, A.L., Sawamura, T., Tannetta, D.S., Sargent, I.L. and Davidge, S.T.


Developmental endothelial locus-1 (Del-1) inhibits oxidized low-density lipoprotein activity by direct binding, and its overexpression attenuates atherogenesis in mice.
Circ J 2016
Author:Kakino, A., Fujita, Y., Nakano, A., Horiuchi, S. and Sawamura, T.


Lectin-like oxidized low-density lipoprotein receptor (LOX-1) in sickle cell disease vasculopathy.
Blood Cells Mol Dis,60:44-48 2016
Author:Chen, M., Qiu, H., Lin, X., Nam, D., Ogbu-Nwobodo, L., Archibald, H., Joslin, A., Wun, T., Sawamura, T. and Green, R.


Deletion of LOX-1 protects against heart failure induced by doxorubicin.
PLoS One,11:e0154994 2016
Author:Yokoyama, C., Aoyama, T., Ido, T., Kakino, A., Shiraki, T., Tanaka, T., Nishigaki, K., Hasegawa, A., Fujita, Y., Sawamura, T. and Minatoguchi, S.


High levels of soluble lectin-like oxidized low-density lipoprotein receptor-1 in acute stroke: an age- and sex-matched cross-sectional study.
J Atheroscler Thromb,23:1222-1226 2016
Author:Yokota, C., Sawamura, T., Watanabe, M., Kokubo, Y., Fujita, Y., Kakino, A., Nakai, M., Toyoda, K., Miyamoto, Y. and Minematsu, K.


Electronegative low-density lipoprotein increases coronary artery disease risk in uremia patients on maintenance hemodialysis.
Medicine (Baltimore),95:e2265 2016
Author:Chang, C.T., Wang, G.J., Kuo, C.C., Hsieh, J.Y., Lee, A.S., Chang, C.M., Wang, C.C., Shen, M.Y., Huang, C.C., Sawamura, T., Yang, C.Y., Stancel, N. and Chen, C.H.


Lectin-like oxidized low density lipoprotein receptor 1-deficient mice show resistance to instability-induced osteoarthritis.
Scand J Rheumatol,45:412-422 2016
Author:Hashimoto, K., Mori, S., Oda, Y., Nakano, A., Sawamura, T. and Akagi, M.


Serum level of LOX-1 ligand containing ApoB is associated with increased carotid intima-media thickness in Japanese community-dwelling men, especially those with hypercholesterolemiaLOX-1 ligand and IMT in Japanese.
J Clin Lipidol,10:172-180 2016
Author:Okamura, T., Miura, K., Sawamura, T., Kadota, A., Hisamatsu, T., Fujiyoshi, A., Miyamatsu, N., Takashima, N., Miyagawa, N., Kadowaki, T., Ohkubo, T., Murakami, Y., Nakamura, Y., Ueshima, H. and Group, S.R.


Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet aggregation.
Blood,127:1336-1345 2016
Author:Shen, M.Y., Chen, F.Y., Hsu, J.F., Fu, R.H., Chang, C.M., Chang, C.T., Liu, C.H., Wu, J.R., Lee, A.S., Chan, H.C., Sheu, J.R., Lin, S.Z., Shyu, W.C., Sawamura, T., Chang, K.C., Hsu, C.Y. and Chen, C.H.


Increased LDL electronegativity in chronic kidney disease disrupts calcium homeostasis resulting in cardiac dysfunction.
J Mol Cell Cardiol,84:36-44 2015
Author:Chang, K.C., Lee, A.S., Chen, W.Y., Lin, Y.N., Hsu, J.F., Chan, H.C., Chang, C.M., Chang, S.S., Pan, C.C., Sawamura, T., Chang, C.T., Su, M.J. and Chen, C.H.


Cross-talk between LOX-1 and PCSK9 in vascular tissues.
Cardiovasc Res,107:556-567 2015
Author:Ding, Z., Liu, S., Wang, X., Deng, X., Fan, Y., Shahanawaz, J., Shmookler Reis, R.J., Varughese, K.I., Sawamura, T. and Mehta, J.L.


The biphasic effects of oxidized-low density lipoprotein on the vasculogenic function of endothelial progenitor cells.
PLoS One,10:e0123971 2015
Author:Lin, F.Y., Tsao, N.W., Shih, C.M., Lin, Y.W., Yeh, J.S., Chen, J.W., Nakagami, H., Morishita, R., Sawamura, T. and Huang, C.Y.


LOX-1 in atherosclerotic disease.
Clin Chim Acta,440:157-163 2015
Author:Sawamura, T., Wakabayashi, I. and Okamura, T.


The relationship between lectin-like oxidized low-density lipoprotein receptor-1 ligands containing apolipoprotein B and the cardio-ankle vascular index in healthy community inhabitants: The KOBE Study.
J Atheroscler Thromb,22:499-508 2015
Author:Sugiyama, D., Higashiyama, A., Wakabayashi, I., Kubota, Y., Adachi, Y., Hayashibe, A., Kawamura, K., Kuwabara, K., Nishimura, K., Kadota, A., Nishida, Y., Hirata, T., Imano, H., Miyamatsu, N., Miyamoto, Y., Sawamura, T. and Okamura, T.


High-salt in addition to high-fat diet may enhance inflammation and fibrosis in liver steatosis induced by oxidative stress and dyslipidemia in mice.
Lipids Health Dis,14:6 2015
Author:Uetake, Y., Ikeda, H., Irie, R., Tejima, K., Matsui, H., Ogura, S., Wang, H., Mu, S., Hirohama, D., Ando, K., Sawamura, T., Yatomi, Y., Fujita, T. and Shimosawa, T.


Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor.
FASEB J,29:3342-3356 2015
Author:Yamamoto, K., Kakino, A., Takeshita, H., Hayashi, N., Li, L., Nakano, A., Hanasaki-Yamamoto, H., Fujita, Y., Imaizumi, Y., Toyama-Yokoyama, S., Nakama, C., Kawai, T., Takeda, M., Hongyo, K., Oguro, R., Maekawa, Y., Itoh, N., Takami, Y., Onishi, M., Takeya, Y., Sugimoto, K., Kamide, K., Nakagami, H., Ohishi, M., Kurtz, T.W., Sawamura, T. and Rakugi, H.


Human serum amyloid A3 (SAA3) protein, expressed as a fusion protein with SAA2, binds the oxidized low density lipoprotein receptor.
PLoS One,10:e0118835 2015
Author:Tomita, T., Ieguchi, K., Sawamura, T. and Maru, Y.


Lectin-like oxidized low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state.
Bone,75:170-182 2015
Author:Nakayachi, M., Ito, J., Hayashida, C., Ohyama, Y., Kakino, A., Okayasu, M., Sato, T., Ogasawara, T., Kaneda, T., Suda, N., Sawamura, T. and Hakeda, Y.


Effect of sodium tanshinone IIA sulfonate treatment in a rat model of preeclampsia.
Am J Physiol Regul Integr Comp Physiol,308:R163-172 2015
Author:Morton, J.S., Quon, A., Cheung, P.Y., Sawamura, T. and Davidge, S.T.


Increased LDL electronegativity in chronic kidney disease disrupts calcium homeostasis resulting in cardiac dysfunction.
J Mol Cell,84:36-44 2015
Author:Chang, K.C., Lee, A.S., Chen, W.Y., Lin, Y.N., Hsu, J.F., Chan, H.C., Chang, C.M., Chang, S.S., Pan, C.C., Sawamura, T., Chang, C.T., Su, M.J. and Chen, C.H.


Pitavastatin decreases serum LOX-1 ligand levels and MT1-MMP expression in CD14-positive mononuclear cells in hypercholesterolemic patients.
Int J Cardiol,176:1230-1232 2014
Author:Uzui, H., Hayashi, H., Nakae, I., Matsumoto, T., Uenishi, H., Hayasaki, H., Asaji, T., Matsui, S., Miwa, K., Lee, J.D., Tada, H., Sawamura, T. and Fujita, M.


LOX-1 plays an important role in ischemia-induced angiogenesis of limbs.
PLoS One,9:e114542 2014
Author:Shiraki, T., Aoyama, T., Yokoyama, C., Hayakawa, Y., Tanaka, T., Nishigaki, K., Sawamura, T. and Minatoguchi, S.


Significance of soluble lectin-like oxidized LDL receptor-1 levels in systemic and coronary circulation in acute coronary syndrome.
Biomed Res Int,2014:649185 2014
Author:Misaka, T., Suzuki, S., Sakamoto, N., Yamaki, T., Sugimoto, K., Kunii, H., Nakazato, K., Saitoh, S., Sawamura, T., Ishibashi, T. and Takeishi, Y.


Prevention of export of anoxia/reoxygenation injury from ischemic to nonischemic cardiomyocytes via inhibition of endocytosis.
Am J Physiol Heart Circ Physiol,306:H1700-1707 2014
Author:Khaidakov, M., Mercanti, F., Wang, X., Ding, Z., Dai, Y., Romeo, F., Sawamura, T. and Mehta, J.L.


Small dense low-density lipoproteins cholesterol can predict incident cardiovascular disease in an urban Japanese cohort: the Suita study.
J Atheroscler Thromb,20:195-203 2013
Author:Arai, H., Kokubo, Y., Watanabe, M., Sawamura, T., Ito, Y., Minagawa, A., Okamura, T. and Miyamato, Y.


Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation.
Blood,122(22):3632-3641 2013
Author:Chan, H.C., Ke, L.Y., Chu, C.S., Lee, A.S., Shen, M.Y., Cruz, M.A., Hsu, J.F., Cheng, K.H., Chan, H.C., Lu, J., Lai, W.T., Sawamura, T., Sheu, S.H., Yen, J.H. and Chen, C.H.


Electronegative low-density lipoprotein increases C-reactive protein expression in vascular endothelial cells through the LOX-1 receptor.
PLoS One,8:e70533 2013
Author:Chu, C.S., Wang, Y.C., Lu, L.S., Walton, B., Yilmaz, H.R., Huang, R.Y., Sawamura, T., Dixon, R.A., Lai, W.T., Chen, C.H. and Lu, J.


Inhibition of lectin-like oxidized low-density lipoprotein-1 receptor protects against plasma-mediated vascular dysfunction associated with pre-eclampsia.
Am J Hypertens,26:279-286 2013
Author:English, F.A., McCarthy, F.P., McSweeney, C.L., Quon, A.L., Morton, J.S., Sawamura, T., Davidge, S.T. and Kenny, L.C.


LOX-1 ligands containing apolipoprotein B and carotid intima-media thickness in middle-aged community-dwelling US Caucasian and Japanese men.
Atherosclerosis,229:240-245 2013
Author:Okamura, T., Sekikawa, A., Sawamura, T., Kadowaki, T., Barinas-Mitchell, E., Mackey, R.H., Kadota, A., Evans, R.W., Edmundowicz, D., Higashiyama, A., Nakamura, Y., Abbott, R.D., Miura, K., Fujiyoshi, A., Fujita, Y., Murakami, Y., Miyamatsu, N., Kakino, A., Maegawa, H., Murata, K., Horie, M., Mitsunami, K., Kashiwagi, A., Kuller, L.H., Ueshima, H. and Group, E.J.S.


Lectin-like oxidized low-density lipoprotein receptor-1 plays an important role in vascular inflammation in current smokers.
J Atheroscler Thromb,20:585-590 2013
Author:Takanabe-Mori, R., Ono, K., Wada, H., Takaya, T., Ura, S., Yamakage, H., Satoh-Asahara, N., Shimatsu, A., Takahashi, Y., Fujita, M., Fujita, Y., Sawamura, T. and Hasegawa, K.


Oxidized Low Density Lipoprotein (LDL) Affects Hyaluronan Synthesis in Human Aortic Smooth Muscle Cells.
J Biol Chem,288:29595-29603 2013
Author:Viola, M., Bartolini, B., Vigetti, D., Karousou, E., Moretto, P., Deleonibus, S., Sawamura, T., Wight, T.N., Hascall, V.C., De Luca, G. and Passi, A.:


Lectin-like oxidized low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis.
Arthritis Rheum,64:1024-1034 2012
Author:Ishikawa, M., Ito, H., Akiyoshi, M., Kume, N., Yoshitomi, H., Mitsuoka, H., Tanida, S., Murata, K., Shibuya, H., Kasahara, T., Kakino, A., Fujita, Y., Sawamura, T., Yasuda, T. and Nakamura, T.


Lectin-like oxidized low-density lipoprotein 1 receptor in a reduced uteroplacental perfusion pressure rat model of preeclampsia.
Hypertension,59:1014-1020 2012
Author:Morton, J.S., Abdalvand, A., Jiang, Y., Sawamura, T., Uwiera, R.R. and Davidge, S.T.


Dietary cholesterol oxidation products accelerate plaque destabilization and rupture associated with monocyte infiltration/activation via the MCP-1-CCR2 pathway in mouse brachiocephalic arteries: therapeutic effects of ezetimibe.
J Atheroscler Thromb,19:986-998 2012
Author:Sato, K., Nakano, K., Katsuki, S., Matoba, T., Osada, K., Sawamura, T., Sunagawa, K. and Egashira, K.


LOX-1 deletion improves neutrophil responses, enhances bacterial clearance, and reduces lung injury in a murine polymicrobial sepsis model.
Infect Immun,79:2865-2870 2011
Author:Wu, Z., Sawamura, T., Kurdowska, A.K., Ji, H.L., Idell, S. and Fu, J.


Lectin-like oxidized LDL receptor 1 is involved in CRP-mediated complement activation.
Clin Chem,57:1398-1405 2011
Author:Fujita, Y., Yamaguchi, S., Kakino, A., Iwamoto, S., Yoshimoto, R. and Sawamura, T.


An alternative protein standard to measure activity of LOX-1 ligand containing apoB (LAB) - utilization of anti-LOX-1 single- chain antibody fused to apoB fragment.
J Atheroscler Thromb,18:818-828 2011
Author:Iwamoto, S., Fujita, Y., Kakino, A., Yanagida, K., Matsuda, H., Yoshimoto, R. and Sawamura, T.


Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox.
Proc Jpn Acad Ser B Phys Biol Sci,87:104-113 2011
Author:Nishizuka, T., Fujita, Y., Sato, Y., Nakano, A., Kakino, A., Ohshima, S., Kanda, T., Yoshimoto, R. and Sawamura, T.


Associations of atherosclerotic risk factors with oxidized low-density lipoprotein evaluated by LOX-1 ligand activity in healthy men.
Clin Chim Acta,412:1643-1647 2011
Author:Uchida, K., Suehiro, A., Nakanishi, M., Sawamura, T. and Wakabayashi, I.


LOX-1 mediates vascular lipid retention under hypertensive state.
J Hypertens,28:1273-1280 2010
Author:Nakano, A., Inoue, N., Sato, Y., Nishimichi, N., Takikawa, K., Fujita, Y., Kakino, A., Otsui, K., Yamaguchi, S., Matsuda, H. and Sawamura, T.


Oxidized LDL receptor LOX-1 binds to C-reactive protein and mediates its vascular effects.
Clin Chem,55:285-294 2009
Author:Fujita, Y., Kakino, A., Nishimichi, N., Yamaguchi, S., Sato, Y., Machida, S., Cominacini, L., Delneste, Y., Matsuda, H. and Sawamura, T.


A novel gene silencer, pyrrole-imidazole polyamide targeting human lectin-like oxidized low-density lipoprotein receptor-1 gene improves endothelial cell function.
J Hypertens,27:508-516 2009
Author:Ueno, T., Fukuda, N., Tsunemi, A., Yao, E.H., Matsuda, H., Tahira, K., Matsumoto, T., Matsumoto, K., Matsumoto, Y., Nagase, H., Sugiyama, H. and Sawamura, T


Mediation of electronegative low-density lipoprotein signaling by LOX-1: a possible mechanism of endothelial apoptosis.
Circ Res,104:619-627 2009
Author:Lu, J., Yang, J.H., Burns, A.R., Chen, H.H., Tang, D., Walterscheid, J.P., Suzuki, S., Yang, C.Y., Sawamura, T. and Chen, C.H.


LOX-1 dependent overexpression of immunoglobulins in cardiomyocytes in response to angiotensin II.
Biochem Biophys Res Commun,379:395-399 2009
Author:Kang, B.Y., Hu, C., Prayaga, S., Khaidakov, M., Sawamura, T., Seung, K.B. and Mehta, J.L.


Increased lectin-like oxidized low-density lipoprotein receptor-1 expression in the maternal vasculature of women with preeclampsia: role for peroxynitrite.
Hypertension,53:270-277 2009
Author:Sankaralingam, S., Xu, Y., Sawamura, T. and Davidge, S.T.


Oxidized LDL binding to LOX-1 enhances MCP-1 expression in cultured human articular chondrocytes.
,17:271-275 2009
Author:Akagi, M., Ueda, A., Teramura, T., Kanata, S., Sawamura, T. and Hamanishi, C.


Suppression of choroidal neovascularization in lectin-like oxidized low-density lipoprotein receptor type 1-deficient mice.
Invest Ophthalmol Vis Sci,50:3970-3976 2009
Author:Inomata, Y., Fukushima, M., Hara, R., Takahashi, E., Honjo, M., Koga, T., Kawaji, T., Satoh, H., Takeya, M., Sawamura, T. and Tanihara, H.


LOX-1 augments oxLDL uptake by lysoPC-stimulated murine macrophages but is not required for oxLDL clearance from plasma.
J Lipid Res,50:1676-1684 2009
Author:Schaeffer, D.F., Riazy, M., Parhar, K.S., Chen, J.H., Duronio, V., Sawamura, T. and Steinbrecher, U.P.


LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells.
Cardiovasc Res,84:127-136 2009
Author:Sugimoto, K., Ishibashi, T., Sawamura, T., Inoue, N., Kamioka, M., Uekita, H., Ohkawara, H., Sakamoto, T., Sakamoto, N., Okamoto, Y., Takuwa, Y., Kakino, A., Fujita, Y., Tanaka, T., Teramoto, T., Maruyama, Y. and Takeishi, Y.


Role of LOX-1 in monocyte adhesion-triggered redox, Akt/eNOS and Ca2+ signaling pathways in endothelial cells.
J Cell Physiol,220:706-715 2009
Author:Sakamoto, N., Ishibashi, T., Sugimoto, K., Sawamura, T., Sakamoto, T., Inoue, N., Saitoh, S., Kamioka, M., Uekita, H., Ohkawara, H., Suzuki, K., Teramoto, T., Maruyama, Y. and Takeishi, Y.


Impaired vascular function in small resistance arteries of LOX-1 overexpressing mice on high-fat diet.
Cardiovasc Res,82:493-502 2009
Author:Eichhorn, B., Muller, G., Leuner, A., Sawamura, T., Ravens, U. and Morawietz, H.


Evidence for increased methylglyoxal in the vasculature of women with preeclampsia: role in upregulation of LOX-1 and arginase.
Hypertension,54:897-904 2009
Author:Sankaralingam, S., Xu, H., Jiang, Y., Sawamura, T. and Davidge, S.T.


Induction of bovine articular chondrocyte senescence with oxidized low-density lipoprotein through lectin-like oxidized low-density lipoprotein receptor 1.
Arthritis Rheum,60:3007-3016 2009
Author:Zushi, S., Akagi, M., Kishimoto, H., Teramura, T., Sawamura, T. and Hamanishi, C.


Generation and characterization of chicken monoclonal antibodies against human LOX-1.
MAbs,1:357-363 2009
Author:Iwamoto, S., Nishimichi, N., Tateishi, Y., Sato, Y., Horiuchi, H., Furusawa, S., Sawamura, T. and Matsuda, H.


LOX-1 abrogation reduces myocardial ischemia-reperfusion injury in mice.
J Mol Cell Cardiol,44:76-83 2008
Author:Hu, C., Chen, J., Dandapat, A., Fujita, Y., Inoue, N., Kawase, Y., Jishage, K., Suzuki, H., Li, D., Hermonat, P.L., Sawamura, T. and Mehta, J.L.


Electronegative LDL circulating in smokers impairs endothelial progenitor cell differentiation by inhibiting Akt phosphorylation via LOX-1.
J Lipid Res,49:33-47 2008
Author:Tang, D., Lu, J., Walterscheid, J.P., Chen, H.H., Engler, D.A., Sawamura, T., Chang, P.Y., Safi, H.J., Yang, C.Y. and Chen, C.H.


Determination of LOX-1-ligand activity in mouse plasma with a chicken monoclonal antibody for ApoB.
Atherosclerosis,200:303-309 2008
Author:Sato, Y., Nishimichi, N., Nakano, A., Takikawa, K., Inoue, N., Matsuda, H. and Sawamura, T.


Essential role of NOXA1 in generation of reactive oxygen species induced by oxidized low-density lipoprotein in human vascular endothelial cells.
Endothelium,15:137-141 2008
Author:Honjo, T., Otsui, K., Shiraki, R., Kawashima, S., Sawamura, T., Yokoyama, M. and Inoue, N.


Novel gene silencer pyrrole-imidazole polyamide targeting lectin-like oxidized low-density lipoprotein receptor-1 attenuates restenosis of the artery after injury.
Hypertension,52::86-92 2008
Author:Yao, E.H., Fukuda, N., Ueno, T., Matsuda, H., Matsumoto, K., Nagase, H., Matsumoto, Y., Takasaka, A., Serie, K., Sugiyama, H. and Sawamura, T.


Impact of plasma oxidized low-density lipoprotein removal on atherosclerosis.
Circulation,118:75-83 2008
Author:Ishigaki, Y., Katagiri, H., Gao, J., Yamada, T., Imai, J., Uno, K., Hasegawa, Y., Kaneko, K., Ogihara, T., Ishihara, H., Sato, Y., Takikawa, K., Nishimichi, N., Matsuda, H., Sawamura, T. and Oka, Y.


LOX-1 deletion decreases collagen accumulation in atherosclerotic plaque in low-density lipoprotein receptor knockout mice fed a high-cholesterol diet.
Cardiovasc Res,79:287-293 2008
Author:Hu, C., Dandapat, A., Sun, L., Chen, J., Marwali, M.R., Romeo, F., Sawamura, T. and Mehta, J.L.


Modulation of angiotensin II-mediated hypertension and cardiac remodeling by lectin-like oxidized low-density lipoprotein receptor-1 deletion.
Hypertension,52:556-562 2008
Author:Hu, C., Dandapat, A., Sun, L., Marwali, M.R., Inoue, N., Sugawara, F., Inoue, K., Kawase, Y., Jishage, K., Suzuki, H., Hermonat, P.L., Sawamura, T. and Mehta, J.L.


Importance of forkhead transcription factor Fkhl18 for development of testicular vasculature.
Mol Reprod Dev,75:1361-1371 2008
Author:Sato, Y., Baba, T., Zubair, M., Miyabayashi, K., Toyama, Y., Maekawa, M., Owaki, A., Mizusaki, H., Sawamura, T., Toshimori, K., Morohashi, K. and Katoh-Fukui, Y.


Expression and localization of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in murine and human placentas.
J Histochem Cytochem,56:773-784 2008
Author:Satoh, H., Kiyota, E., Terasaki, Y., Sawamura, T., Takagi, K., Mizuta, H. and Takeya, M.


LDL protein nitration: implication for LDL protein unfolding.
Arch Biochem Biophys,479:1-14 2008
Author:Hamilton, R.T., Asatryan, L., Nilsen, J.T., Isas, J.M., Gallaher, T.K., Sawamura, T. and Hsiai, T.K.


Possible involvement of the oxidized low-density lipoprotein/lectin-like oxidized low-density lipoprotein receptor-1 system in pathogenesis and progression of human osteoarthritis.
Osteoarthritis Cartilage,15:281-290 2007
Author:Akagi, M., Kanata, S., Mori, S., Itabe, H., Sawamura, T. and Hamanishi, C.


Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet.
Circ Res,100:1634-1642 2007
Author:Mehta, J.L., Sanada, N., Hu, C.P., Chen, J., Dandapat, A., Sugawara, F., Satoh, H., Inoue, K., Kawase, Y., Jishage, K., Suzuki, H., Takeya, M., Schnackenberg, L., Beger, R., Hermonat, P.L., Thomas, M. and Sawamura, T.


Modulation of ADP-induced platelet activation by aspirin and pravastatin: role of lectin-like oxidized low-density lipoprotein receptor-1, nitric oxide, oxidative stress, and inside-out integrin signaling.
J Pharmacol Exp Ther,322:1324-1332 2007
Author:Marwali, M.R., Hu, C.P., Mohandas, B., Dandapat, A., Deonikar, P., Chen, J., Cawich, I., Sawamura, T., Kavdia, M. and Mehta, J.L.


LOX-1 deletion alters signals of myocardial remodeling immediately after ischemia-reperfusion.
Cardiovasc Res,76:292-302 2007
Author:Hu, C., Dandapat, A., Chen, J., Fujita, Y., Inoue, N., Kawase, Y., Jishage, K., Suzuki, H., Sawamura, T. and Mehta, J.L.


Oxidized LDL receptor LOX-1 is involved in neointimal hyperplasia after balloon arterial injury in a rat model.
Cardiovasc Res,69:263-271 2006
Author:Hinagata, J., Kakutani, M., Fujii, T., Naruko, T., Inoue, N., Fujita, Y., Mehta, J.L., Ueda, M. and Sawamura, T.


LOX-1 scavenger receptor mediates calcium-dependent recognition of phosphatidylserine and apoptotic cells.
Biochem J,393:107-115 2006
Author:Murphy, J.E., Tacon, D., Tedbury, P.R., Hadden, J.M., Knowling, S., Sawamura, T., Peckham, M., Phillips, S.E., Walker, J.H. and Ponnambalam, S.


Oxidized low density lipoprotein impairs endothelial progenitor cells by regulation of endothelial nitric oxide synthase.
J Lipid Res,47:1227-1237 2006
Author:Ma, F.X., Zhou, B., Chen, Z., Ren, Q., Lu, S.H., Sawamura, T. and Han, Z.C.


Dominant-negative LOX-1 blocks homodimerization of wild-type LOX-1-induced cell proliferation through extracellular signal regulated kinase 1/2 activation.
Hypertension,48:294-300 2006
Author:Tanigawa, H., Miura, S., Matsuo, Y., Fujino, M., Sawamura, T. and Saku, K.


Cyclic tensile stretch load and oxidized low density lipoprotein synergistically induce lectin-like oxidized ldl receptor-1 in cultured bovine chondrocytes, resulting in decreased cell viability and proteoglycan synthesis.
J Orthop Res,24:1782-1790 2006
Author:Akagi, M., Nishimura, S., Yoshida, K., Kakinuma, T., Sawamura, T., Munakata, H. and Hamanishi, C.


Oxidized LDL binding to LOX-1 upregulates VEGF expression in cultured bovine chondrocytes through activation of PPAR-gamma.
Biochem Biophys Res Commun,348:1003-1010 2006
Author:Kanata, S., Akagi, M., Nishimura, S., Hayakawa, S., Yoshida, K., Sawamura, T., Munakata, H. and Hamanishi, C.


Low-density lipoprotein oxidized to various degrees activates ERK1/2 through LOX-1.
Atherosclerosis,188:245-250 2006
Author:Tanigawa, H., Miura, S., Zhang, B., Uehara, Y., Matsuo, Y., Fujino, M., Sawamura, T. and Saku, K.


Antioxidants suppress plasma levels of lectinlike oxidized low-density lipoprotein receptor-ligands and reduce atherosclerosis in watanabe heritable hyperlipidemic rabbits.
J Cardiovasc Pharmacol,48:177-183 2006
Author:Oka, K., Yasuhara, M., Suzumura, K., Tanaka, K. and Sawamura, T.


Atorvastatin reduces platelet-oxidized-LDL receptor expression in hypercholesterolaemic patients.
Eur J Clin Invest,35:47-51 2005
Author:Puccetti, L., Sawamura, T., Pasqui, A.L., Pastorelli, M., Auteri, A. and Bruni, F.


Nebivolol decreases oxidative stress in essential hypertensive patients and increases nitric oxide by reducing its oxidative inactivation.
J Hypertens,23:589-596 2005
Author:Pasini, A.F., Garbin, U., Nava, M.C., Stranieri, C., Davoli, A., Sawamura, T., Lo Cascio, V. and Cominacini, L.


Extracellular HSP70 binding to surface receptors present on antigen presenting cells and endothelial/epithelial cells.
FEBS Lett,579:1951-1960 2005
Author:Theriault, J.R., Mambula, S.S., Sawamura, T., Stevenson, M.A. and Calderwood, S.K.


Angiotensin II increases the expression of lectin-like oxidized low-density lipoprotein receptor-1 in human vascular smooth muscle cells via a lipoxygenase-dependent pathway.
Am J Hypertens,18:299-307 2005
Author:Limor, R., Kaplan, M., Sawamura, T., Sharon, O., Keidar, S., Weisinger, G., Knoll, E., Naidich, M. and Stern, N.


Overexpression of lectin-like oxidized low-density lipoprotein receptor-1 induces intramyocardial vasculopathy in apolipoprotein E-null mice.
Circ Res,97:176-184 2005
Author:Inoue, K., Arai, Y., Kurihara, H., Kita, T. and Sawamura, T.


Essential role of cytoplasmic sequences for cell-surface sorting of the lectin-like oxidized LDL receptor-1 (LOX-1).
J Mol Cell Cardiol,39:553-561 2005
Author:Chen, M. and Sawamura, T.


Adhesion molecule expression in fibroblasts: alteration in fibroblast biology after transfection with LOX-1 plasmids.
Hypertension,46:622-627 2005
Author:Chen, K., Chen, J., Liu, Y., Xie, J., Li, D., Sawamura, T., Hermonat, P.L. and Mehta, J.L.


Enhanced plasma levels of oxidized low-density lipoprotein increase circulating nuclear factor-kappa B activation in patients with unstable angina.
J Am Coll Cardiol,46:799-806 2005
Author:Cominacini, L., Anselmi, M., Garbin, U., Fratta Pasini, A., Stranieri, C., Fusaro, M., Nava, C., Agostoni, P., Keta, D., Zardini, P., Sawamura, T. and Lo Cascio, V.


Different effect of statins on platelet oxidized-LDL receptor (CD36 and LOX-1) expression in hypercholesterolemic subjects.
Clin Appl Thromb Hemost,11:417-428 2005
Author:Bruni, F., Pasqui, A.L., Pastorelli, M., Bova, G., Cercignani, M., Palazzuoli, A., Sawamura, T., Gioffre, W.R., Auteri, A. and Puccetti, L.


Glucose enhances human macrophage LOX-1 expression: role for LOX-1 in glucose-induced macrophage foam cell formation.
Circ Res,94:892-901 2004
Author:Li, L., Sawamura, T. and Renier, G.


Asymmetric dimethylarginine upregulates LOX-1 in activated macrophages: role in foam cell formation.
,287:H782-790 2004
Author:Smirnova, I.V., Kajstura, M., Sawamura, T. and Goligorsky, M.S.


Oxidized low-density lipoprotein induces endothelial progenitor cell senescence, leading to cellular dysfunction.
Clin Exp Pharmacol Physiol,31:407-413 2004
Author:Imanishi, T., Hano, T., Sawamura, T. and Nishio, I.


Oxidized low-density lipoprotein (ox-LDL) binding to lectin-like ox-LDL receptor-1 (LOX-1) in cultured bovine articular chondrocytes increases production of intracellular reactive oxygen species (ROS) resulting in the activation of NF-kappaB.
Osteoarthritis Cartilage,12:568-576 2004
Author:Nishimura, S., Akagi, M., Yoshida, K., Hayakawa, S., Sawamura, T., Munakata, H. and Hamanishi, C.


Upregulation of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in endothelial cells by nitric oxide deficiency.
Am J Physiol Renal Physiol,287:F25-32 2004
Author:Smirnova, I.V., Sawamura, T. and Goligorsky, M.S.


Lipids from oxidized low-density lipoprotein modulate human trophoblast invasion: involvement of nuclear liver X receptors.
Endocrinology,145:4583-4591 2004
Author:Pavan, L., Hermouet, A., Tsatsaris, V., Therond, P., Sawamura, T., Evain-Brion, D. and Fournier, T.


C-reactive protein enhances LOX-1 expression in human aortic endothelial cells: relevance of LOX-1 to C-reactive protein-induced endothelial dysfunction.
Circ Res,95:877-883 2004
Author:Li, L., Roumeliotis, N., Sawamura, T. and Renier, G.


Expression of lectin-like oxidized low-density lipoprotein receptor-1 in allografted hearts.
Transplant Proc,36:2440-2442 2004
Author:Suga, M., Sawamura, T., Nakatani, T. and Kitamura, S


Lectin-like oxidized low-density lipoprotein receptor 1 mediates matrix metalloproteinase 3 synthesis enhanced by oxidized low-density lipoprotein in rheumatoid arthritis cartilage.
Arthritis Rheum,50:3495-3503 2004
Author:Kakinuma, T., Yasuda, T., Nakagawa, T., Hiramitsu, T., Akiyoshi, M., Akagi, M., Sawamura, T. and Nakamura, T.


Induction of endothelin-1 production in endothelial cells via co-operative action between CD40 and lectin-like oxidized LDL receptor (LOX-1).
J Cardiovasc Pharmacol,44:S173-180 2004
Author:Sakurai, K., Cominacini, L., Garbin, U., Fratta Pasini, A., Sasaki, N., Takuwa, Y., Masaki, T. and Sawamura, T.


Expression of LOX-1, an oxidized low-density lipoprotein receptor, in choroidal neovascularization.
Arch Ophthalmol,122 2004
Author:Honjo, M., Sawamura, T., Hinagata, J., Nakamura, K., Sanada, N., Tanihara, H., Honda, Y. and Kiryu, J.


Dynamin-2 regulates oxidized low-density lipoprotein-induced apoptosis of vascular smooth muscle cell.
Circulation,110:3329-3334 2004
Author:Kashiwakura, Y., Watanabe, M., Kusumi, N., Sumiyoshi, K., Nasu, Y., Yamada, H., Sawamura, T., Kumon, H., Takei, K. and Daida, H.


LOX-1 pathway affects the extent of myocardial ischemia-reperfusion injury.
Biochem Biophys Res Commun,300:656-660 2003
Author:Kataoka, K., Hasegawa, K., Sawamura, T., Fujita, M., Yanazume, T., Iwai-Kanai, E., Kawamura, T., Hirai, T., Kita, T. and Nohara, R.


Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation.
Proc Natl Acad Sci U S A,100:1274-1279 2003
Author:Honjo, M., Nakamura, K., Yamashiro, K., Kiryu, J., Tanihara, H., McEvoy, L.M., Honda, Y., Butcher, E.C., Masaki, T. and Sawamura, T.


LOX-1 mediates oxidized low-density lipoprotein-induced expression of matrix metalloproteinases in human coronary artery endothelial cells.
Circulation,107:612-617 2003
Author:Li, D., Liu, L., Chen, H., Sawamura, T., Ranganathan, S. and Mehta, J.L.


Nebivolol and its 4-keto derivative increase nitric oxide in endothelial cells by reducing its oxidative inactivation.
J Am Coll Cardiol,42:1838-1844 2003
Author:Cominacini, L., Fratta Pasini, A., Garbin, U., Nava, C., Davoli, A., Criscuoli, M., Crea, A., Sawamura, T. and Lo Cascio, V.


Oxidized LDL receptor gene (OLR1) is associated with the risk of myocardial infarction.
Biochem Biophys Res Commun 2003
Author:Tatsuguchi, M., Furutani, M., Hinagata, J., Tanaka, T., Furutani, Y., Imamura, S., Kawana, M., Masaki, T., Kasanuki, H., Sawamura, T. and Matsuoka, R.


Expression of lectin-like oxidized low-density lipoprotein receptors during ischemia-reperfusion and its role in determination of apoptosis and left ventricular dysfunction.
J Am Coll Cardiol,41:1048-1055 2003
Author:Li, D., Williams, V., Liu, L., Chen, H., Sawamura, T., Romeo, F. and Mehta, J.L.


LOX-1, an oxidized LDL endothelial receptor, induces CD40/CD40L signaling in human coronary artery endothelial cells.
Arterioscler Thromb Vasc Biol,23:816-821 2003
Author:Li, D., Liu, L., Chen, H., Sawamura, T. and Mehta, J.L.


Lipid-lowering-independent effects of simvastatin on the kidney in experimental hypercholesterolaemia.
Nephrol Dial Transplant,18:703-709 2003
Author:Wilson, S.H., Chade, A.R., Feldstein, A., Sawamura, T., Napoli, C., Lerman, A. and Lerman, L.O.:


Hypercholesterolemia and hypertension have synergistic deleterious effects on coronary endothelial function.
Arterioscler Thromb Vasc Biol,23:885-891 2003
Author:Rodriguez-Porcel, M., Lerman, L.O., Herrmann, J., Sawamura, T., Napoli, C. and Lerman, A.


Napoli, C. and Lerman, L.O.: Hypertension exacerbates the effect of hypercholesterolemia on the myocardial microvasculature.
Cardiovasc Res,58:213-221 2003
Author:Rodriguez-Porcel, M., Lerman, A., Herrmann, J., Schwartz, R.S., Sawamura, T., Condorelli, M., Napoli, C. and Lerman, L.O.


Mechanisms of renal structural alterations in combined hypercholesterolemia and renal artery stenosis.
Arterioscler Thromb Vasc Biol,23:1295-1301 2003
Author:Chade, A.R., Rodriguez-Porcel, M., Grande, J.P., Zhu, X., Sica, V., Napoli, C., Sawamura, T., Textor, S.C., Lerman, A. and Lerman, L.O.


Glucose enhances endothelial LOX-1 expression: role for LOX-1 in glucose-induced human monocyte adhesion to endothelium.
Diabetes,52:1843-1850 2003
Author:Li, L., Sawamura, T. and Renier, G.


Oxidized LDL through LOX-1 modulates LDL-receptor expression in human coronary artery endothelial cells.
Biochem Biophys Res Commun,307:1008-1012 2003
Author:Hu, B., Li, D., Sawamura, T. and Mehta, J.L.


Endothelin-1 receptor blockade prevents renal injury in experimental hypercholesterolemia.
Kidney Int,64:962-969 2003
Author:Chade, A.R., Best, P.J., Rodriguez-Porcel, M., Herrmann, J., Zhu, X., Sawamura, T., Napoli, C., Lerman, A. and Lerman, L.O.


The platelet-endothelium interaction mediated by lectin-like oxidized low-density lipoprotein receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells.
J Am Coll Cardiol,41:499-507 2003
Author:Cominacini, L., Fratta Pasini, A., Garbin, U., Pastorino, A., Rigoni, A., Nava, C., Davoli, A., Lo Cascio, V. and Sawamura, T.


Modulation of endothelial Ca(2+)-activated K(+) channels by oxidized LDL and its contribution to endothelial proliferation.
Cardiovasc Res,60:626-634 2003
Author:Kuhlmann, C.R., Schafer, M., Li, F., Sawamura, T., Tillmanns, H., Waldecker, B. and Wiecha, J.


Statin inhibits leukocyte-endothelial interaction and prevents neuronal death induced by ischemia-reperfusion injury in the rat retina.
Arch Ophthalmol,120:1707-1713 2002
Author:Honjo, M., Tanihara, H., Nishijima, K., Kiryu, J., Honda, Y., Yue, B.Y. and Sawamura, T


Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) serves as an endothelial receptor for advanced glycation end products (AGE).
FEBS Lett,511:170-174 2002
Author:Jono, T., Miyazaki, A., Nagai, R., Sawamura, T., Kitamura, T. and Horiuchi, S.


Statins modulate oxidized low-density lipoprotein-mediated adhesion molecule expression in human coronary artery endothelial cells: role of LOX-1.
J Pharmacol Exp Ther,302:601-605 2002
Author:Li, D., Chen, H., Romeo, F., Sawamura, T., Saldeen, T. and Mehta, J.L.


A myosin light chain kinase inhibitor, ML-9, lowers the intraocular pressure in rabbit eyes.
,75:135-142 2002
Author:Honjo, M., Inatani, M., Kido, N., Sawamura, T., Yue, B.Y., Honda, Y. and Tanihara, H.


Augmented endothelial uptake of oxidized low-density lipoprotein in response to endothelin-1
Clin Sci (Lond),48:9S-12S 2002
Author:Morawietz, H., Duerrschmidt, N., Niemann, B., Galle, J., Sawamura, T. and Holtz, J.


Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation.
Immunity,17:353-362 2002
Author:Delneste, Y., Magistrelli, G., Gauchat, J., Haeuw, J., Aubry, J., Nakamura, K., Kawakami-Honda, N., Goetsch, L., Sawamura, T., Bonnefoy, J. and Jeannin, P.


Lectin-like oxidized low-density lipoprotein receptor 1 mediates leukocyte infiltration and articular cartilage destruction in rat zymosan-induced arthritis.
Arthritis Rheum,46:2486-2494 2002
Author:Nakagawa, T., Akagi, M., Hoshikawa, H., Chen, M., Yasuda, T., Mukai, S., Ohsawa, K., Masaki, T., Nakamura, T. and Sawamura, T.


LOX-1 inhibition in myocardial ischemia-reperfusion injury: modulation of MMP-1 and inflammation.
Am J Physiol Heart Circ Physiol,,283:H1795-1801 2002
Author:Li, D., Williams, V., Liu, L., Chen, H., Sawamura, T., Antakli, T. and Mehta, J.L


Oxidized low density lipoprotein potentiation of Fas-induced apoptosis through lectin-like oxidized-low density lipoprotein receptor-1 in human umbilical vascular endothelial cells.
Circ J,66:1060-1064 2002
Author:Imanishi, T., Hano, T., Sawamura, T., Takarada, S. and Nishio, I.


LOX-1 expressed in cultured rat chondrocytes mediates oxidized LDL-induced cell death-possible role of dephosphorylation of Akt.
Biochem Biophys Res Commun,299:91-97 2002
Author:Nakagawa, T., Yasuda, T., Hoshikawa, H., Shimizu, M., Kakinuma, T., Chen, M., Masaki, T., Nakamura, T. and Sawamura, T.


Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) supports cell adhesion to fibronectin.
FEBS Lett,504:65-68 2001
Author:Shimaoka, T., Kume, N., Minami, M., Hayashida, K., Sawamura, T., Kita, T. and Yonehara, S.


Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility.
Invest Ophthalmol Vis Sci,42:137-144 2001
Author:Honjo, M., Tanihara, H., Inatani, M., Kido, N., Sawamura, T., Yue, B.Y., Narumiya, S. and Honda, Y.


Pericardial fluid from patients with ischemic heart disease induces myocardial cell apoptotis via an oxidant stress-sensitive p38 mitogen-activated protein kinase pathway.
J Mol Cell Cardiol,33:419-430 2001
Author:Iwakura, A., Fujita, M., Hasegawa, K., Toyokuni, S., Sawamura, T., Nohara, R., Sasayama, S. and Komeda, M.


Identification of peptides that target the endothelial cell-specific LOX-1 receptor.
Hypertension,37:449-455 2001
Author:White, S.J., Nicklin, S.A., Sawamura, T. and Baker, A.H.


Redox-sensitive regulation of lox-1 gene expression in vascular endothelium.
Biochem Biophys Res Commun,281:720-725 2001
Author:Nagase, M., Ando, K., Nagase, T., Kaname, S., Sawamura, T. and Fujita, T.


Activation-dependent surface expression of LOX-1 in human platelets.
Biochem Biophys Res Commun,,282:153-158 2001
Author:Chen, M., Kakutani, M., Naruko, T., Ueda, M., Narumiya, S., Masaki, T. and Sawamura, T.


Accumulation of LOX-1 ligand in plasma and atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits: identification by a novel enzyme immunoassay.
Biochem Biophys Res Commun,282:180-185 2001
Author:Kakutani, M., Ueda, M., Naruko, T., Masaki, T. and Sawamura, T.


The binding of oxidized low density lipoprotein (ox-LDL) to ox-LDL receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells through an increased production of superoxide.
J Biol Chem,276:13750-13755 2001
Author:Cominacini, L., Rigoni, A., Pasini, A.F., Garbin, U., Davoli, A., Campagnola, M., Pastorino, A.M., Lo Cascio, V. and Sawamura, T.


Conserved C-terminal residues within the lectin-like domain of LOX-1 are essential for oxidized low-density-lipoprotein binding.
Biochem J,355:289-296 2001
Author:Chen, M., Narumiya, S., Masaki, T. and Sawamura, T.


LOX-1 supports adhesion of Gram-positive and Gram-negative bacteria.
J Immunol,166:5108-5114 2001
Author:Shimaoka, T., Kume, N., Minami, M., Hayashida, K., Sawamura, T., Kita, T. and Yonehara, S.


8-iso-prostaglandin F(2alpha) increases expression of LOX-1 in JAR cells.
Hypertension,37:1184-1190 2001
Author:Halvorsen, B., Staff, A.C., Henriksen, T., Sawamura, T. and Ranheim, T.


Induction of the oxLDL receptor LOX-1 by endothelin-1 in human endothelial cells.
Biochem Biophys Res Commun,284:961-965 2001
Author:Morawietz, H., Duerrschmidt, N., Niemann, B., Galle, J., Sawamura, T. and Holtz, J.


Requirements of basic amino acid residues within the lectin-like domain of LOX-1 for the binding of oxidized low-density lipoprotein.
FEBS Lett,499:215-219 2001
Author:Chen, M., Inoue, K., Narumiya, S., Masaki, T. and Sawamura, T.


Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes.
Arch Ophthalmol,119:1171-1178 2001
Author:Honjo, M., Inatani, M., Kido, N., Sawamura, T., Yue, B.Y., Honda, Y. and Tanihara, H.


Diabetes enhances lectin-like oxidized LDL receptor-1 (LOX-1) expression in the vascular endothelium: possible role of LOX-1 ligand and AGE.
Biochem Biophys Res Commun,287:962-968 2001
Author:Chen, M., Nagase, M., Fujita, T., Narumiya, S., Masaki, T. and Sawamura, T.


Activation of lectin-like oxidized low-density lipoprotein receptor-1 induces apoptosis in cultured neonatal rat cardiac myocytes.
Circulation,104:2948-2954 2001
Author:Iwai-Kanai, E., Hasegawa, K., Sawamura, T., Fujita, M., Yanazume, T., Toyokuni, S., Adachi, S., Kihara, Y. and Sasayama, S.


A platelet-endothelium interaction mediated by lectin-like oxidized low-density lipoprotein receptor-1.
Proc Natl Acad Sci U S A,97:360-364 2000
Author:Kakutani, M., Masaki, T. and Sawamura, T.


LOX-1 mediates lysophosphatidylcholine-induced oxidized LDL uptake in smooth muscle cells.
FEBS Lett,467:217-220 2000
Author:Aoyama, T., Chen, M., Fujiwara, H., Masaki, T. and Sawamura, T.


Biosynthesis and post-translational processing of lectin-like oxidized low density lipoprotein receptor-1 (LOX-1). N-linked glycosylation affects cell-surface expression and ligand binding.
J Biol Chem,275:6573-6579 2000
Author:Kataoka, H., Kume, N., Miyamoto, S., Minami, M., Murase, T., Sawamura, T., Masaki, T., Hashimoto, N. and Kita, T.


Identification of soluble forms of lectin-like oxidized LDL receptor-1.
Arterioscler Thromb Vasc Biol,20 2000
Author:Murase, T., Kume, N., Kataoka, H., Minami, M., Sawamura, T., Masaki, T. and Kita, T.


Increased expression of lectin-like oxidized low density lipoprotein receptor-1 in initial atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits.
Arterioscler Thromb Vasc Biol,20:1107-1115, 2000
Author:Chen, M., Kakutani, M., Minami, M., Kataoka, H., Kume, N., Narumiya, S., Kita, T., Masaki, T. and Sawamura, T.


Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species.
J Biol Chem,275:12633-12638 2000
Author:Cominacini, L., Pasini, A.F., Garbin, U., Davoli, A., Tosetti, M.L., Campagnola, M., Rigoni, A., Pastorino, A.M., Lo Cascio, V. and Sawamura, T.


Transforming growth factor-beta(1) increases the expression of lectin-like oxidized low-density lipoprotein receptor-1.
Biochem Biophys Res Commun,,272 2000
Author:Minami, M., Kume, N., Kataoka, H., Morimoto, M., Hayashida, K., Sawamura, T., Masaki, T. and Kita, T.


Pericardial fluid from patients with unstable angina induces vascular endothelial cell apoptosis.
J Am Coll Cardiol,35:1785-1790 2000
Author:Iwakura, A., Fujita, M., Hasegawa, K., Sawamura, T., Nohara, R., Sasayama, S. and Komeda, M.


Inducible expression of LOX-1, a novel receptor for oxidized LDL, in macrophages and vascular smooth muscle cells.
Ann N Y Acad Sci,902:323-327 2000
Author:Kume, N., Moriwaki, H., Kataoka, H., Minami, M., Murase, T., Sawamura, T., Masaki, T. and Kita, T.


Expression of lectin-like oxidized LDL receptor-1 in human atherosclerotic lesions.
Ann N Y Acad Sci,902:328-335 2000
Author:Kataoka, H., Kume, N., Minami, M., Moriwaki, H., Sawamura, T., Masaki, T. and Kita, T.


Pericardial fluid from patients with ischemic heart disease accelerates the growth of human vascular smooth muscle cells.
Jpn Circ J,64:495-498 2000
Author:Yoneda, T., Fujita, M., Kihara, Y., Hasegawa, K., Sawamura, T., Tanaka, T., Inanami, M., Nohara, R. and Sasayama, S.


Expression of LOX-1, an oxidized low-density lipoprotein receptor, in experimental hypertensive glomerulosclerosis.
J Am Soc Nephrol,11:1826-1836, 2000
Author:Nagase, M., Kaname, S., Nagase, T., Wang, G., Ando, K., Sawamura, T. and Fujita, T.


Upregulation of LOX-1 expression in aorta of hypercholesterolemic rabbits: modulation by losartan.
Biochem Biophys Res Commun,276:1100-1104 2000
Author:Chen, H., Li, D., Sawamura, T., Inoue, K. and Mehta, J.L.


Endothelin-1 as a protective factor against beta-adrenergic agonist-induced apoptosis in cardiac myocytes.
J Am Coll Cardiol,36:1411-1418 2000
Author:Araki, M., Hasegawa, K., Iwai-Kanai, E., Fujita, M., Sawamura, T., Kakita, T., Wada, H., Morimoto, T. and Sasayama, S.


Regeneration of cardiac muscle in normal adult C57BL/6 mice.
Cardiac and Vascular Regeneration,1:268-273 2000
Author:Jiang, H., Hidaka, K., Sawamura, T., Arai, Y., Takihara, Y., Ota, A. and Morisaki, T.


The role of endothelin-converting enzyme-1 in the development of alpha1-adrenergic-stimulated hypertrophy in cultured neonatal rat cardiac myocytes.
Circulation,99:292-298 1999
Author:Kaburagi, S., Hasegawa, K., Morimoto, T., Araki, M., Sawamura, T., Masaki, T. and Sasayama, S.


Structure and chromosomal assignment of the human lectin-like oxidized low-density-lipoprotein receptor-1 (LOX-1) gene.
Biochem J,339:177-184 1999
Author:Aoyama, T., Sawamura, T., Furutani, Y., Matsuoka, R., Yoshida, M.C., Fujiwara, H. and Masaki, T.


Upregulation of endothelial receptor for oxidized low-density lipoprotein (LOX-1) in cultured human coronary artery endothelial cells by angiotensin II type 1 receptor activation.
Circ Res,84:1043-1049 1999
Author:Li, D.Y., Zhang, Y.C., Philips, M.I., Sawamura, T. and Mehta, J.L.


Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions.
Circulation,99:3110-3117 1999
Author:Kataoka, H., Kume, N., Miyamoto, S., Minami, M., Moriwaki, H., Murase, T., Sawamura, T., Masaki, T., Hashimoto, N. and Kita, T.


Neuron-specific expression of cationic amino acid transporter 3 in the adult rat brain.
Brain Res,838:158-165 1999
Author:Hosokawa, H., Ninomiya, H., Sawamura, T., Sugimoto, Y., Ichikawa, A., Fujiwara, K. and Masaki, T.


Angiotensin II induces LOX-1, the human endothelial receptor for oxidized low-density lipoprotein.
Circulation,100:899-902 1999
Author:Morawietz, H., Rueckschloss, U., Niemann, B., Duerrschmidt, N., Galle, J., Hakim, K., Zerkowski, H.R., Sawamura, T. and Holtz, J.


Induction of lectin-like oxidized LDL receptor by oxidized LDL and lysophosphatidylcholine in cultured endothelial cells.
J Mol Cell Cardiol,31:2101-2114 1999
Author:Aoyama, T., Fujiwara, H., Masaki, T. and Sawamura, T.


Marked elevation of vascular endothelial growth factor and basic fibroblast growth factor in pericardial fluid of patients with angina pectoris.
Angiogenesis,2:105-108 1998
Author:Fujita, M., Ikemoto, M., Tanaka, T., Tamaki, S., Yamazato, A., Sawamura, T., Hasegawa, K., Kihara, Y., Nohara, R. and Sasayama, S.


High affinity binding of oxidized LDL to mouse lectin-like oxidized LDL receptor (LOX-1).
Biochem Biophys Res Commun,245:841-846 1998
Author:Hoshikawa, H., Sawamura, T., Kakutani, M., Aoyama, T., Nakamura, T. and Masaki, T.


The processing pathway of endothelin-1 production.
J Cardiovasc Pharmacol,31:S13-15 1998
Author:Kido, T., Sawamura, T. and Masaki, T.


Increased Cat3-mediated cationic amino acid transport functionally compensates in Cat1 knockout cell lines.
J Biol Chem,273:14663-14666 1998
Author:183. Nicholson, B., Sawamura, T., Masaki, T. and MacLeod, C.L.


Purification of a novel endothelin-converting enzyme specific for big endothelin-3.
FEBS Lett,428:304-308 1998
Author:Hasegawa, H., Hiki, K., Sawamura, T., Aoyama, T., Okamoto, Y., Miwa, S., Shimohama, S., Kimura, J. and Masaki, T.


Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells.
Proc Natl Acad Sci U S A,95:9535-9540 1998
Author:Oka, K., Sawamura, T., Kikuta, K., Itokawa, S., Kume, N., Kita, T. and Masaki, T.


Inducible expression of lectin-like oxidized LDL receptor-1 in vascular endothelial cells.
Circ Res,83:322-327 1998
Author:Kume, N., Murase, T., Moriwaki, H., Aoyama, T., Sawamura, T., Masaki, T. and Kita, T.


Fluid shear stress transcriptionally induces lectin-like oxidized LDL receptor-1 in vascular endothelial cells.
Circ Res,83:328-333 1998
Author:187. Murase, T., Kume, N., Korenaga, R., Ando, J., Sawamura, T., Masaki, T. and Kita, T.


Role of nonselective cation channels as Ca2+ entry pathway in endothelin-1-induced contraction and their suppression by nitric oxide.
Eur J Pharmacol,352:237-245 1998
Author:Zhang, X.F., Komuro, T., Miwa, S., Minowa, T., Iwamuro, Y., Okamoto, Y., Ninomiya, H., Sawamura, T. and Masaki, T.


Ligand specificity of LOX-1, a novel endothelial receptor for oxidized low density lipoprotein.
Arterioscler Thromb Vasc Biol,18:1541-1547 1998
Author:Moriwaki, H., Kume, N., Sawamura, T., Aoyama, T., Hoshikawa, H., Ochi, H., Nishi, E., Masaki, T. and Kita, T.


High-affinity arginine transport of bovine aortic endothelial cells is impaired by lysophosphatidylcholine.
Circ Res,83:1088-1096 1998
Author:Kikuta, K., Sawamura, T., Miwa, S., Hashimoto, N. and Masaki, T.


Expression of lectin-like oxidized low density lipoprotein receptor-1 in human and murine macrophages: upregulated expression by TNF-alpha.
FEBS Lett,440:29-32 1998
Author:1Moriwaki, H., Kume, N., Kataoka, H., Murase, T., Nishi, E., Sawamura, T., Masaki, T. and Kita, T.


Cloning and characterization of a brain-specific cationic amino acid transporter.
J Biol Chem,272:8717-8722 1997
Author:Hosokawa, H., Sawamura, T., Kobayashi, S., Ninomiya, H., Miwa, S. and Masaki, T.


An endothelial receptor for oxidized low-density lipoprotein.
Nature,386:73-77 1997
Author:Sawamura, T., Kume, N., Aoyama, T., Moriwaki, H., Hoshikawa, H., Aiba, Y., Tanaka, T., Miwa, S., Katsura, Y., Kita, T. and Masaki, T.


Processing of proendothelin-1 at the C-terminus of big endothelin-1 is essential for proteolysis by endothelin-converting enzyme-1 in vivo.
Eur J Biochem,244:520-526 1997
Author:Kido, T., Sawamura, T., Hoshikawa, H., D'Orleans-Juste, P., Denault, J.B., Leduc, R., Kimura, J. and Masaki, T.


Enhanced expression of endothelial oxidized low-density lipoprotein receptor (LOX-1) in hypertensive rats.
Biochem Biophys Res Commun,237:496-498 1997
Author:Nagase, M., Hirose, S., Sawamura, T., Masaki, T. and Fujita, T.


Physiological role of Ca2+-permeable nonselective cation channel in endothelin-1-induced contraction of rabbit aorta.
J Cardiovasc Pharmacol,30:504-509 1997
Author:Komuro, T., Miwa, S., Zhang, X.F., Minowa, T., Enoki, T., Kobayashi, S., Okamoto, Y., Ninomiya, H., Sawamura, T., Kikuta, K., Iwamuro, Y., Furutani, H., Hasegawa, H., Uemura, Y., Kikuchi, H. and Masaki, T.


Human endothelin converting enzyme gene (ECE1) mapped to chromosomal region 1p36.1.
Cytogenet Cell Genet,72:322-324 1996
Author:Matsuoka, R., Sawamura, T., Yamada, K., Yoshida, M., Furutani, Y., Ikura, T., Shiraki, T., Hoshikawa, H., Shimada, K., Tanzawa, K. and Masaki, T.


Processing of proendothelin-1 by human furin convertase.
FEBS Lett,362:276-280 1995
Author:Denault, J.B., Claing, A., D'Orleans-Juste, P., Sawamura, T., Kido, T., Masaki, T. and Leduc, R.


Genetic transfer of endothelin converting enzyme activity to CHO-K1 cells: detection of positive cells by reverse hemolytic plaque assay.
FEBS Lett,351:197-200 1994
Author:Shiraki, T., Sawamura, T., Ikura, T., Kobayashi, S., Miwa, S. and Masaki, T.


cDNA cloning and expression of bovine endothelin converting enzyme.
Biochem Biophys Res Commun,203:1417-1422 1994
Author:Ikura, T., Sawamura, T., Shiraki, T., Hosokawa, H., Kido, T., Hoshikawa, H., Shimada, K., Tanzawa, K., Kobayashi, S., Miwa, S. and Masaki, T.


Characterization of phosphoramidon-sensitive metalloproteinases with endothelin-converting enzyme activity in porcine lung membrane.
Biochim Biophys Acta,1161:295-302 1993
Author:Sawamura, T., Shinmi, O., Kishi, N., Sugita, Y., Yanagisawa, M., Goto, K., Masaki, T. and Kimura, S.


Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists.
J Biol Chem,268:8547-8553 1993
Author:Sakamoto, A., Yanagisawa, M., Sawamura, T., Enoki, T., Ohtani, T., Sakurai, T., Nakao, K., Toyo-oka, T. and Masaki,


Distribution of endothelin-like immunoreactivity and mRNA in the developing and adult human lung.
Am J Respir Cell Mol Biol,4:50-58 1991
Author:Giaid, A., Polak, J.M., Gaitonde, V., Hamid, Q.A., Moscoso, G., Legon, S., Uwanogho, D., Roncalli, M., Shinmi, O., Sawamura, T., Kimura, S., Yanagisawa, M., Masaki, T. and Springal, D.R.


Phosphoramidon inhibits the intracellular conversion of big endothelin-1 to endothelin-1 in cultured endothelial cells.
Biochem Biophys Res Commun,174:779-784 1991
Author:Sawamura, T., Kasuya, Y., Matsushita, Y., Suzuki, N., Shinmi, O., Kishi, N., Sugita, Y., Yanagisawa, M., Goto, K., Masaki, T. and Kimura, S.


Purification and characterization of putative endothelin converting enzyme in bovine adrenal medulla: evidence for a cathepsin D-like enzyme.
Biochem Biophys Res Commun,168:1230-1236 1990
Author:Sawamura, T., Kimura, S., Shinmi, O., Sugita, Y., Yanagisawa, M., Goto, K. and Masaki, T.


Characterization of endothelin converting enzyme activities in soluble fraction of bovine cultured endothelial cells.
Biochem Biophys Res Commun,169:1138-1144 1990
Author:Sawamura, T., Kimura, S., Shinmi, O., Sugita, Y., Kobayashi, M., Mitsui, Y., Yanagisawa, M., Goto, K. and Masaki, T.


Increased maternal plasma concentration of endothelin-1 during labor pain or on delivery and the existence of a large amount of endothelin-1 in amniotic fluid.
Gynecol Endocrinol,4:85-97 1990
Author:Usuki, S., Saitoh, T., Sawamura, T., Suzuki, N., Shigemitsu, S., Yanagisawa, M., Goto, K., Onda, H., Fujino, M. and Masaki, T.


Detection of endothelin immunoreactivity and mRNA in pulmonary tumours.
162,:15-22 1990
Author:Giaid, A., Hamid, Q.A., Springall, D.R., Yanagisawa, M., Shinmi, O., Sawamura, T., Masaki, T., Kimura, S., Corrin, B. and Polak, J.M.


Analysis of big endothelin-1 digestion by cathepsin D.
Biochem Biophys Res Commun,172:883-889 1990
Author:Sawamura, T., Shinmi, O., Kishi, N., Sugita, Y., Yanagisawa, M., Goto, K., Masaki, T. and Kimura, S.


Conversion of big endothelin-1 to 21-residue endothelin-1 is essential for expression of full vasoconstrictor activity: structure-activity relationships of big endothelin-1.
J Cardiovasc Pharmacol,13:S5-7 1989
Author:Kimura, S., Kasuya, Y., Sawamura, T., Shinimi, O., Sugita, Y., Yanagisawa, M., Goto, K. and Masaki, T.


Presence of endothelin-1 in porcine spinal cord: isolation and sequence determination.
Biochem Biophys Res Commun,162:340-346 1989
Author:Shinmi, O., Kimura, S., Yoshizawa, T., Sawamura, T., Uchiyama, Y., Sugita, Y., Kanazawa, I., Yanagisawa, M., Goto, K. and Masaki, T.


Analysis of endothelin related peptides in culture supernatant of porcine aortic endothelial cells: evidence for biosynthetic pathway of endothelin-1.
Biochem Biophys Res Commun,162:1287-1294 1989
Author:Sawamura, T., Kimura, S., Shinmi, O., Sugita, Y., Yanagisawa, M. and Masaki, T.


Endothelin-3 is a novel neuropeptide: isolation and sequence determination of endothelin-1 and endothelin-3 in porcine brain.
Biochem Biophys Res Commun,164:587-593 1989
Author:Shinmi, O., Kimura, S., Sawamura, T., Sugita, Y., Yoshizawa, T., Uchiyama, Y., Yanagisawa, M., Goto, K., Masaki, T. and Kanazawa, I.


Structure-activity relationships of endothelin: importance of the C-terminal moiety.
Biochem Biophys Res Commun,156:1182-1186 1988
Author:Kimura, S., Kasuya, Y., Sawamura, T., Shinmi, O., Sugita, Y., Yanagisawa, M., Goto, K. and Masaki, T.