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田渕克彦  タブチ カツヒコ

教員組織学術研究院(医学系)電話番号
教育組織先鋭領域融合研究群 バイオメディカル研究所 神経難病学部門FAX番号
職名教授メールアドレス
住所〒390-8621 長野県松本市旭3-1-1ホームページURLhttps://nrid.nii.ac.jp/ja/nrid/1000020546767/

プロフィール

兼担研究科・学部
医学部 医学科 分子細胞生理学
研究分野
神経生理学・神経科学一般
解剖学一般(含組織学・発生学)
医化学一般
薬理学一般
生理学一般
神経解剖学・神経病理学
キーワード:神経変性疾患 , アルツハイマー病 , 精神疾患 , 自閉症 , シナプス , 包括脳ネットワーク
所属学会
所属学会
日本神経科学会
日本生理学会
日本解剖学会
日本生化学会
北米神経科学会
学歴
出身大学院
1999 , 大阪大学 , 大学院博士課程医学研究科 , 生理学専攻

出身学校・専攻等(大学院を除く)
1995 , 筑波大学 , 医学部
研究職歴等
研究職歴
2014- , 信州大学学術研究院医学系 分子細胞生理学教室 教授
2012-2014 , 信州大学医学部 分子細胞生理学講座 教授
2009-2012 , 生理学研究所 准教授
2008-2009 , Stanford University School of Medicine Life Science Research Associate
2007-2008 , UT Southwestern Medical Center Instructor
2005-2007 , UT Southwestern Medical Center Assistant Instructor
2001-2005 , Postdoctoral fellow UT Southwestern Medical Center
1999-2001 , Postdoctoral fellow Howard Hughes Medical Institute

研究活動業績

研究業績(著書・
発表論文等)
著書
モデルマウスに見るシナプス成熟障害と自閉症との関係
日本神経精神薬理学雑誌(Jpn. J. Neuropsychopharmacol.) , 34:1-4 2014(Feb. 25)
Author:田渕克彦 張文欣 Nur Farehan Mohamed Asgar Gopal Pramanik


シナプスと自閉症
生体の科学 , 65(1):3-6 2014(Feb. 15)
Author:田渕克彦


ニューレグリン受容体(ERBB4)の異常と精神疾患
生体の科学 , 4(5):470-471 2013
Author:田渕克彦


信州大学医学部神経生理学講座
神経化学 , 52(1):39-40 2013
Author:田渕克彦


Analysis of Neuroligin-3 R451C knock-in mice as models for autistic savant
日本生物学的精神医学会誌 , 23(4):281-286 2012
Author:Deeba Noreen Baig, 柳川徹, 田渕克彦


Neuroligin
先端医学社 , 分子精神医学 , 11(3):207-208 2011
Author:田渕克彦


Neuroligins and Neurexins in Autism
American Psychiatric Publishing, Inc , Textbook of Autism Spectrum Disorders , :347-352 2011
Author:Katsuhiko Tabuchi


論文
Deficiency of calcium/calmodulin-dependent serine protein kinase (CASK) disrupts the excitatory-inhibitory balance of synapses by down-regulating GluN2B.
Molecular Psychiatry 2019(Jan.)
Author:Mori T, Kasem EA, Suzuki-Kouyama E, Cao X, Kurihara T, Uemura T, Yanagawa T, Tabuchi K.


PTPσ Drives Excitatory Presynaptic Assembly via Various Extracellular and Intracellular Mechanisms.
JOURNAL OF NEUROSCIENCE,38(30):6700-6721 2018(Jul.)
Author:Han, Kyung Ah; Ko, Ji Seung; Pramanik, Gopal; Kim, Jin Young; Tabuchi, Katsuhiko; Um, Ji Won; Ko, Jaewon;


Neurexins and neuropsychiatric disorders
NEUROSCIENCE RESEARCH,127:53-60 2018(Feb.)
Author:Kasem, Enas; Kurihara, Taiga; Tabuchi, Katsuhiko;


Numbers of presynaptic Ca2+ channel clusters match those of functionally defined vesicular docking sites in single central synapses
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,114(26):E5246-E5255 2017(Jun.)
Author:Miki, Takafumi; Kaufmann, Walter A.; Malagon, Gerardo; Gomez, Laura; Tabuchi, Katsuhiko; Watanabe, Masahiko; Shigemoto, Ryuichi; Marty, Alain;


Corrigendum to "p62 modulates the intrinsic signaling of UVB-induced apoptosis" [Journal of Dermatological Science 83 (2016) 226-233].
Journal of dermatological science,86(3):259-260 2017(Jun.)
Author:Ito S, Kimura S, Warabi E, Kawachi Y, Yamatoji M, Uchida F, Ishibashi-Kanno N, Yamagata K, Hasegawa S, Shoda J, Tabuchi K, Sakai S, Bukawa H, Sekido M, Yanagawa T


Functions of synapse adhesion molecules neurexin/neuroligins and neurodevelopmental disorders
NEUROSCIENCE RESEARCH,116:3-9 2017(Mar.)
Author:Cao, Xueshan; Tabuchi, Katsuhiko;


Distortion of the normal function of synaptic cell adhesion molecules by genetic variants as a risk for autism spectrum disorders
BRAIN RESEARCH BULLETIN,129:82-90 2017(Mar.)
Author:Baig, Deeba Noreen; Yanagawa, Toru; Tabuchi, Katsuhiko;


Central synapse, neural circuit, and brain function
NEUROSCIENCE RESEARCH,116:1-2 2017(Mar.)
Author:Takahashi, Hideto; Matsuda, Keiko; Tabuchi, Katsuhiko; Ko, Jaewon;


Fluorescent protein tagging of endogenous protein in brain neurons using CRISPR/Cas9-mediated knock-in and in utero electroporation techniques
SCIENTIFIC REPORTS,6:35861 2016(Oct.)
Author:Uemura, Takeshi; Mori, Takuma; Kurihara, Taiga; Kawase, Shiori; Koike, Rie; Satoga, Michiru; Cao, Xueshan; Li, Xue; Yanagawa, Toru; Sakurai, Takayuki; Shindo, Takayuki; Tabuchi, Katsuhiko;


p62 modulates the intrinsic signaling of UVB-induced apoptosis
JOURNAL OF DERMATOLOGICAL SCIENCE,83(3):226-233 2016(Sep.)
Author:Ito, Sachiko; Kimura, Shintaro; Warabi, Eiji; Kawachi, Yasuhiro; Yamatoji, Masanobu; Uchida, Fumihiko; Ishibashi-Kanno, Naomi; Yamagata, Kenji; Hasegawa, Shogo; Shoda, Junichi; Tabuchi, Katsuhiko; Sakai, Satoshi; Bukawa, Hiroki; Sekido, Mitsuru; Yanagawa, Toru;


IQ Motif and SEC7 Domain-containing Protein 3 (IQSEC3) Interacts with Gephyrin to Promote Inhibitory Synapse Formation
JOURNAL OF BIOLOGICAL CHEMISTRY,291(19):10119-10130 2016(May)
Author:Um, Ji Won; Choii, Gayoung; Park, Dongseok; Kim, Dongwook; Jeon, Sangmin; Kang, Hyeyeon; Mori, Takuma; Papadopoulos, Theofilos; Yoo, Taesun; Lee, Yeunkum; Kim, Eunjoon; Tabuchi, Katsuhiko; Ko, Jaewon;


Distinct circuit-dependent functions of presynaptic neurexin-3 at GABAergic and glutamatergic synapses
NATURE NEUROSCIENCE,18(7):997-1007 2015(Jul.)
Author:Aoto, Jason; Foeldy, Csaba; Ilcus, Silviana Maria Ciurea; Tabuchi, Katsuhiko; Suedhof, Thomas C.;


β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling.
CELL,162(3):593-606 2015
Author:Anderson, Garret R.; Aoto, Jason; Tabuchi, Katsuhiko; Foeldy, Csaba; Covy, Jason; Yee, Ada Xin; Wu, Dick; Lee, Sung-Jin; Chen, Lu; Malenka, Robert C.; Suedhof, Thomas C.;


PTP sigma functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,112(6):1874-1879 2015
Author:Ko, Ji Seung; Pramanik, Gopal; Um, Ji Won; Shim, Ji Seon; Lee, Dongmin; Kim, Kee Hun; Chung, Gug-Young; Condomitti, Giuseppe; Kim, Ho Min; Kim, Hyun; de Wit, Joris; Park, Kang-Sik; Tabuchi, Katsuhiko; Ko, Jaewon;


PDZ interaction of Vangl2 links PSD-95 and Prickle2 but plays only a limited role in the synaptic localisation of Vangl2
SCIENTIFIC REPORTS,5:12916 2015
Author:Nagaoka, Tadahiro; Tabuchi, Katsuhiko; Kishi, Masashi;


Enhanced synapse remodelling as a common phenotype in mouse models of autism
NATURE COMMUNICATIONS,5:4742 2014(Aug.)
Author:Isshiki, Masaaki; Tanaka, Shinji; Kuriu, Toshihiko; Tabuchi, Katsuhiko; Takumi, Toru; Okabe, Shigeo;


Peroxiredoxin I plays a protective role against UVA irradiation through reduction of oxidative stress
JOURNAL OF DERMATOLOGICAL SCIENCE,74(1):9-17 2014(Apr.)
Author:Ito, Takaaki; Kimura, Shintaro; Seto, Kahori; Warabi, Eiji; Kawachi, Yasuhiro; Shoda, Junichi; Tabuchi, Katsuhiko; Yamagata, Kenji; Hasegawa, Shogo; Bukawa, Hiroki; Ishii, Tetsuro; Yanagawa, Toru;


Calsyntenins Function as Synaptogenic Adhesion Molecules in Concert with Neurexins
CELL REPORTS,6(6):1096-1109 2014(Mar.)
Author:Um, Ji Won; Pramanik, Gopal; Ko, Ji Seung; Song, Min-Young; Lee, Dongmin; Kim, Hyun; Park, Kang-Sik; Suedhof, Thomas C.; Tabuchi, Katsuhiko; Ko, Jaewon;


Synapse maturation and autism: learning from neuroligin model mice.
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology,34(1):1-4 2014(Feb.)
Author:Tabuchi K, Chang W, Asgar NF, Pramanik G


Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow
MOLECULAR NEURODEGENERATION,9:28 2014
Author:Li, Hongmei; Guo, Qinxi; Inoue, Taeko; Polito, Vinicia A.; Tabuchi, Katsuhiko; Hammer, Robert E.; Pautler, Robia G.; Taffet, George E.; Zheng, Hui;


Mandibular reconstruction using plates prebent to fit rapid prototyping 3-dimensional printing models ameliorates contour deformity
HEAD & FACE MEDICINE,10:45 2014
Author:Azuma, Masaki; Yanagawa, Toru; Ishibashi-Kanno, Naomi; Uchida, Fumihiko; Ito, Takaaki; Yamagata, Kenji; Hasegawa, Shogo; Sasaki, Kaoru; Adachi, Koji; Tabuchi, Katsuhiko; Sekido, Mitsuru; Bukawa, Hiroki;


Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP (vol 107, pg 17362, 2010)
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,110(32):13228-13228 2013
Author:Li, Hongmei; Wang, Baiping; Wang, Zilai; Guo, Qinxi; Tabuchi, Katsuhiko; Hammer, Robert E.; Suedhof, Thomas C.; Zheng, Hui;


Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,110(2):725-730 2013
Author:Budreck, Elaine C.; Kwon, Oh-Bin; Jung, Jung Hoon; Baudouin, Stephane; Thommen, Albert; Kim, Hye-Sun; Fukazawa, Yugo; Harada, Harumi; Tabuchi, Katsuhiko; Shigemoto, Ryuichi; Scheiffele, Peter; Kim, Joung-Hun;


Presynaptic Neurexin-3 Alternative Splicing trans-Synaptically Controls Postsynaptic AMPA Receptor Trafficking
CELL,154(1):75-88 2013
Author:Aoto, Jason; Martinelli, David C.; Malenka, Robert C.; Tabuchi, Katsuhiko; Suedhof, Thomas C.;


A novel method for evaluating postsurgical results of unilateral cleft lip and palate with the use of Hausdorff distance: presurgical orthopedic treatment improves nasal symmetry after primary cheiloplasty
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY,114(6):704-711 2012(Dec.)
Author:Karube, Rei; Sasaki, Hiroyoshi; Togashi, Shinji; Yanagawa, Toru; Nakane, Shizuo; Ishibashi, Naomi; Yamagata, Kenji; Onizawa, Kojiro; Adachi, Koji; Tabuchi, Katsuhiko; Sekido, Mitsuru; Bukawa, Hiroki;


Presurgical Nasoalveolar Molding Orthopedic Treatment Improves the Outcome of Primary Cheiloplasty of Unilateral Complete Cleft Lip and Palate, as Assessed by Naris Morphology and Cleft Gap
JOURNAL OF CRANIOFACIAL SURGERY,23(6):1596-1601 2012(Nov.)
Author:Sasaki, Hiroyoshi; Togashi, Shinji; Karube, Rei; Yanagawa, Toru; Nakane, Shizuo; Tabuchi, Katsuhiko; Ishibashi, Naomi; Shinya, Yoshiko; Ito, Hiroyuki; Yamagata, Kenji; Onizawa, Kojiro; Adachi, Koji; Sekido, Mitsuru; Bukawa, Hiroki;


Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,108(33):13764-13769 2011(Aug.)
Author:Etherton, Mark; Foeldy, Csaba; Sharma, Manu; Tabuchi, Katsuhiko; Liu, Xinran; Shamloo, Mehrdad; Malenka, Robert C.; Suedhof, Thomas C.;


An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus
EMBO JOURNAL,30(14):2908-2919 2011(Jun.)
Author:Etherton, Mark R.; Tabuchi, Katsuhiko; Sharma, Manu; Ko, Jaewon; Suedhof, Thomas C.;


Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,107(40):17362-17367 2010(Oct. 05)
Author:Li, Hongmei; Wang, Baiping; Wang, Zilai; Guo, Qinxi; Tabuchi, Katsuhiko; Hammer, Robert E.; Suedhof, Thomas C.; Zheng, Hui;


Genetic Dissection of the Amyloid Precursor Protein in Developmental Function and Amyloid Pathogenesis
JOURNAL OF BIOLOGICAL CHEMISTRY,285(40):30598-30605 2010(Oct. 01)
Author:Li, Hongmei; Wang, Zilai; Wang, Baiping; Guo, Qinxi; Dolios, Georgia; Tabuchi, Katsuhiko; Hammer, Robert E.; Suedhof, Thomas C.; Wang, Rong; Zheng, Hui;


Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,107(8):3799-3804 2010(Feb. 02)
Author:Fukata, Yuko; Lovero, Kathryn L.; Iwanaga, Tsuyoshi; Watanabe, Atsushi; Yokoi, Norihiko; Tabuchi, Katsuhiko; Shigemoto, Ryuichi; Nicoll, Roger A.; Fukata, Masaki;


Neuroligin-1 Deletion Results in Impaired Spatial Memory and Increased Repetitive Behavior
JOURNAL OF NEUROSCIENCE,30(6):2115-2129 2010(Feb.)
Author:Blundell, Jacqueline; Blaiss, Cory A.; Etherton, Mark R.; Espinosa, Felipe; Tabuchi, Katsuhiko; Walz, Christopher; Bolliger, Marc F.; Suedhof, Thomas C.; Powell, Craig M.;


Increased anxiety-like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2.
Genes, brain, and behavior,8:114-126 2009(Feb.)
Author:Blundell J, Tabuchi K, Bolliger MF, Blaiss CA, Brose N, Liu X, Südhof TC, Powell CM


シナプス, Neuroliginと自閉症
Cognition and Dementia,8(3):203-208 2009
Author:田渕克彦


自閉症とニューロリギン
Clinical Neuroscience,27(10):1092-1093 2009
Author:田渕克彦


素顔のニューロサイエンティスト Thomas C Sudhof
Clinical Neuroscience,27(8):944 2009
Author:田渕克彦


Conditional Forebrain Inactivation of Nicastrin Causes Progressive Memory Impairment and Age-Related Neurodegeneration
JOURNAL OF NEUROSCIENCE,29(22):7290-7301 2009
Author:Tabuchi, Katsuhiko; Chen, Guiquan; Suedhof, Thomas C.; Shen, Jie;


シナプス機能と自閉症:ニューロリギン遺伝子改変マウスを用いた自閉症病理の探求
実験医学,26(4):545-546 2008
Author:田渕克彦


Loss of cytokeratin 13 expression in squamous cell carcinoma of the tongue is a possible sign for local recurrence.
Journal of experimental & clinical cancer research : CR,26:215-220 2007(Jun.)
Author:Yanagawa T, Yoshida H, Yamagata K, Onizawa K, Tabuchi K, Koyama Y, Iwasa S, Shimoyamada H, Harada H, Omura K


Neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice
SCIENCE,318(5847):71-76 2007
Author:Tabuchi, Katsuhiko; Blundell, Jacqueline; Etherton, Mark R.; Hammer, Robert E.; Liu, Xinran; Powell, Craig M.; Suedhof, Thomas C.;


Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation
JOURNAL OF COMPARATIVE NEUROLOGY,502(2):261-274 2007
Author:Dudanova, Irina; Tabuchi, Katsuhiko; Rohlmann, Astrid; Suedhof, Thomas C.; Missler, Markus;


Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family.
The Journal of neuroscience,26(50):13089-13101 2006(Dec.)
Author:Ho, Angela; Morishita, Wade; Atasoy, Deniz; Liu, Xinran; Tabuchi, Katsuhiko; Hammer, Robert E.; Malenka, Robert C.; Sudhof, Thomas C.;


Nicastrin functions as a gamma-secretase-substrate receptor.
Cell,122(3):435-447 2005(Aug. 01)
Author:Shah S, Lee SF, Tabuchi K, Hao YH, Yu C, LaPlant Q, Ball H, Dann CE 3rd, Südhof T, Yu G


Differences in care-seeking behavior for acute chest pain in the United States and Japan.
American heart journal,147(4):630-635 2004(Apr.)
Author:Liao L, Whellan DJ, Tabuchi K, Schulman KA


Drosophila homeodomain protein REPO controls glial differentiation by cooperating with ETS and BTB transcription factors.
Development,130(11):2419-2428 2003(Jun.)
Author:Yuasa Y, Okabe M, Yoshikawa S, Tabuchi K, Xiong WC, Hiromi Y, Okano H


CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with caskin 1, a novel CASK-binding protein.
The Journal of neuroscience,22(11):4264-4273 2002(Jun.)
Author:Tabuchi K, Biederer T, Butz S, Sudhof TC


Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing.
Genomics,79(6):849-859 2002(Jun.)
Author:Tabuchi K, Südhof TC


Embryonic neuronal death due to neurotrophin and neurotransmitter deprivation occurs independent of Apaf-1.
Neuroscience,106:263-274 2001
Author:Honarpour N, Tabuchi K, Stark JM, Hammer RE, Südhof TC, Parada LF, Wang X, Richardson JA, Herz J


Peroxiredoxin I expression in oral cancer: a potential new tumor marker.
Cancer letters,156:27-35 2000(Aug. 01)
Author:Yanagawa T, Iwasa S, Ishii T, Tabuchi K, Yusa H, Onizawa K, Omura K, Harada H, Suzuki H, Yoshida H


GAL4/UAS-WGA system as a powerful tool for tracing Drosophila transsynaptic neural pathways.
Journal of neuroscience research,59:94-99 2000(Jan. 01)
Author:Tabuchi K, Sawamoto K, Suzuki E, Ozaki K, Sone M, Hama C, Tanifuji-Morimoto T, Yuasa Y, Yoshihara Y, Nose A, Okano H


c-Abl expression in oral squamous cell carcinomas.
Oral oncology,36:89-94 2000(Jan.)
Author:Yanagawa T, Harada H, Iwasa S, Tabuchi K, Omura K, Suzuki H, Yusa H, Yamagata K, Onizawa K, Ishii T, Yoshida H


Peroxiredoxin I expression in human thyroid tumors.
Cancer letters,145:127-132 1999(Oct. 01)
Author:Yanagawa T, Ishikawa T, Ishii T, Tabuchi K, Iwasa S, Bannai S, Omura K, Suzuki H, Yoshida H


Heme oxygenase-1 expression in oral squamous cell carcinoma as involved in lymph node metastasis.
Cancer letters,138:53-59 1999(Apr. 02)
Author:Tsuji MH, Yanagawa T, Iwasa S, Tabuchi K, Onizawa K, Bannai S, Toyooka H, Yoshida H


A genetic approach to visualization of multisynaptic neural pathways using plant lectin transgene.
Neuron,22(1):33-41 1999(Jan.)
Author:Yoshihara Y, Mizuno T, Nakahira M, Kawasaki M, Watanabe Y, Kagamiyama H, Jishage K, Ueda O, Suzuki H, Tabuchi K, Sawamoto K, Okano H, Noda T, Mori K


A novel Drosophila paired-like homeobox gene related to Caenorhabditis elegans unc-4 is expressed in subsets of postmitotic neurons and epidermal cells.
Neuroscience letters,257(1):49-52 1998(Nov. 02)
Author:Tabuchi K, Yoshikawa S, Yuasa Y, Sawamoto K, Okano H


Localization of 5-HT2A receptor in rat cerebral cortex and olfactory system revealed by immunohistochemistry using two antibodies raised in rabbit and chicken.
Brain research. Molecular brain research,54(2):199-211 1998(Mar. 01)
Author:Hamada S, Senzaki K, Hamaguchi-Hamada K, Tabuchi K, Yamamoto H, Yamamoto T, Yoshikawa S, Okano H, Okado N


学会発表
Synapse maturation and autism : The role of synapse adhesion molecules
JOURNAL OF PHYSIOLOGICAL SCIENCES , 63:S29-S29 2013
Author:Tabuchi, Katsuhiko; Chang Wen Hsin; Nur Farehan, Asgar Mohamed; Thomas, Sudhof C.; Shigemoto, Ryuichi;


Genetic Animal Models of Autism
ANNALS OF NEUROLOGY , 68(4):S31-S31 2010
Author:Blundell, Jacqueline; Blaiss, Cory A.; Etherton, Mark R.; Zhou, Jing; Kwon, Chang-Hyuk; Espinosa, Felipe; Tabuchi, Katsuhiko; Bolliger, Marc E.; Parada, Luis F.; Sudhof, Thomas C.; Powell, Craig M.;


Novel Genetic Animal Models of Autism: Molecular Mechanisms to Therapeutic Targets
NEUROLOGY , 72(11):A489-A489 2009
Author:Powell, Craig M.; Blundell, Jacqueline; Tabuchi, Katsuhiko; Zhou, Jing; Kwon, Chang; Etherton, Mark; Hammer, Robert; Liu, Xinran; Parada, Luis; Sudhof, Thomas C.;


Analysis of neuroligin-3 knock-in mice relevant to autism spectrum disorders
NEUROSCIENCE RESEARCH , 65:S257-S257 2009
Author:Tabuchi, Katsuhiko; Etherton, Mark; Shigemoto, Ryuichi; Sudhof, Thomas;


Genetic Animal Models of Autism: Molecular Mechanisms and Potential Therapeutics
ANNALS OF NEUROLOGY , 66:S59-S60 2009
Author:Blundell, Jacqueline; Blaiss, Cory; Tabuchi, Katsuhiko; Zhou, Jing; Kwon, Chang; Bolliger, Marc; Parada, Luis; Sudhof, Thomas C.; Powell, Craig M.;


Autism as synapsopathy: Animal models based on genetic mutations in trans-synaptic cell adhesion molecules
ANNALS OF NEUROLOGY , 64:S64-S64 2008
Author:Blundell, Jacqueline; Tabuchi, Katsuhiko; Bolliger, Marc; Brose, Nils; Sudhof, Thomas C.; Powell, Craig M.;


Neuroligin deletion results in autism & mental retardation-related behavioral abnormalities
ANNALS OF NEUROLOGY , 62:S50-S50 2007
Author:Blundell, Jacqueline; Tabuchi, Katsuhiko; Bolliger, Marc; Brose, Nils; Sudhof, Thomas C.; Powell, Craig M.;

研究費
科学研究費補助金(研究代表者)
2013 - 2016 , Neurexinの結合特異性を操作したマウスを用いた自閉症の分子経路の解明 , 基盤研究(B)
2012 - 2014 , DREADDシステムを用いたシナプス成熟技術の開発 , 挑戦的萌芽研究
2011 - 2012 , 神経伝達物質受容体のシナプス膜面での動態を規定する分子のスクリーニング技術の開発 , 挑戦的萌芽研究
2009 - 2010 , Neuroligin遺伝子改変自閉症モデルマウスのシナプス機能の解析 , 研究活動スタート支援

科学研究費補助金(研究分担者)
2013 - 2014 , 口腔癌におけるシナプス接着因子を標的とした新規抗血管新生療法の探索 , 挑戦的萌芽研究
2011 - 2012 , CASKノックアウトマウスを用いた口蓋裂形成シグナルの解明 , 挑戦的萌芽研究

その他公的資金
精神発達障害原因解明のためのNeuroligin/Neurexinモデルの確立

教育活動実績

授業等
後期 , 生理学(統御系)
後期 , 生化学II