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上松一永  アゲマツ カズナガ

教員組織学術研究院(医学系)電話番号
教育組織医学部 医学科 病理学FAX番号
職名准教授メールアドレス
住所ホームページURL

更新日:2018/09/11

プロフィール

研究分野
免疫学
現在の研究課題
メモリーB細胞機能の研究

所属学会
所属学会
日本免疫学会
日本臨床免疫学会
日本寄生虫学会
学歴
出身大学院
1992 , 信州大学 , 医学研究科

出身学校・専攻等(大学院を除く)
1984 , 新潟大学 , 医学部

取得学位
医学博士
研究職歴等
研究職歴
2001- , 信州大学 助教授
1997-2001 , 信州大学 講師
1994-1997 , 信州大学 助手
1992-1994 , 信州大学大学院(医学研究科) 博士課程単位修得

研究活動業績

研究業績(著書・
発表論文等)
著書
自己炎症性症候群
朝倉書店 , 矢崎義雄『内科学 第10版』 , :1328-1330 2013
Author:上松一永


論文
Heterozygous Mutations in OAS1 Cause Infantile-Onset Pulmonary Alveolar Proteinosis with Hypogammaglobulinemia
AMERICAN JOURNAL OF HUMAN GENETICS,102(3):480-486 2018
Author:Cho, Kazutoshi; Yamada, Masafumi; Agematsu, Kazunaga; Kanegane, Hirokazu; Miyake, Noriko; Ueki, Masahiro; Akimoto, Takuma; Kobayashi, Norimoto; Ikemoto, Satoru; Tanino, Mishie; Fujita, Atsushi; Hayasaka, Itaru; Miyamoto, Satoshi; Tanaka-Kubota, Mari; Nakata, Koh; Shiina, Masaaki; Ogata, Kazuhiro; Minakami, Hisanori; Matsumoto, Naomichi; Ariga, Tadashi;


Functional analysis of 2 amino acids deleted transcription factor C/EBP epsilon found in neutrophil-specific granule deficiency
CYTOKINE,100:148-148 2017(Dec.)
Author:Akagi, Tadayuki; Wada, Taizo; Muraoka, Masahiro; Toma, Tomoko; Kaji, Kenzo; Agematsu, Kazunaga; Koeffler, H. Phillip; Yachie, Akihiro; Yokota, Takashi;


Acute Myeloid Leukemia in a Patient With X-linked Severe Combined Immunodeficiency
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY,39(8):E470-E472 2017(Nov.)
Author:Shigemura, Tomonari; Motobayashi, Mitsuo; Matsuda, Kazuyuki; Shimodaira, Takahiro; Kurata, Takashi; Kobayashi, Norimoto; Agematsu, Kazunaga; Nakazawa, Yozo;


Poly (I:C) and hyaluronic acid directly interact with NLRP3, resulting in the assembly of NLRP3 and ASC in a cell-free system
EUROPEAN JOURNAL OF INFLAMMATION,15(2):85-97 2017(Aug.)
Author:Kaneko, Naoe; Ito, Yuki; Iwasaki, Tomoyuki; Takeda, Hiroyuki; Sawasaki, Tatsuya; Migita, Kiyoshi; Agematsu, Kazunaga; Koga, Tomohiro; Kawakami, Atsushi; Yachie, Akihiro; Yoshiura, Koh-ichiro; Morikawa, Shinnosuke; Kurata, Mie; Masumoto, Junya;


Early diagnosis of early-onset sarcoidosis: a case report with functional analysis and review of the literature
CLINICAL RHEUMATOLOGY,36(5):1189-1196 2017(May)
Author:Takeuchi, Yusuke; Shigemura, Tomonari; Kobayashi, Norimoto; Kaneko, Naoe; Iwasaki, Tomoyuki; Minami, Kisei; Kobayashi, Keiko; Masumoto, Junya; Agematsu, Kazunaga;


Familial Mediterranean fever with P369S/R408Q exon3 variant in pyrin presenting as symptoms of PFAPA.
Mod Rheumatol,21:1-8 2016(Dec.)
Author:Yamagami K, Nakamura T, Nakamura R, Hanioka Y, Seki K, Chiba H, Kobayashi K, Agematsu K.


Markedly elevated CD64 expression on neutrophils and monocytes as a biomarker for diagnosis and therapy assessment in Kawasaki disease.
Inflamm Res,65(7):579-85 2016(Jul.)
Author:Hokibara S, Kobayashi N, Kobayashi K, Shigemura T, Nagumo H, Takizawa M, Yamazaki T, Agematsu K.


Familial Mediterranean fever is no longer a rare disease in Japan.
Arthritis Res Ther,18:175 2016(Jul.)
Author:Migita K, Izumi Y, Jiuchi Y, Iwanaga N, Kawahara C, Agematsu K, Yachie A, Masumoto J, Fujikawa K, Yamasaki S, Nakamura T, Ubara Y, Koga T, Nakashima Y, Shimizu T, Umeda M, Nonaka F, Yasunami M, Eguchi K, Yoshiura K, Kawakami A.


Immune Complex-Mediated Glomerulonephritis in a Patient with Wiskott-Aldrich Syndrome.
J Clin Immunol,36(4):357-9 2016(May)
Author:Shigemura T, Nakazawa Y, Shimojo H, Kobayashi N, Agematsu K.


Novel heterozygous C243Y A20/TNFAIP3 gene mutation is responsible for chronic inflammation in autosomal-dominant Behçet's disease.
RMD Open,2(1):e000223 2016(May)
Author:Shigemura T, Kaneko N, Kobayashi N, Kobayashi K, Takeuchi Y, Nakano N, Masumoto J, Agematsu K.


Multiple Serum Cytokine Profiling to Identify Combinational Diagnostic Biomarkers in Attacks of Familial Mediterranean Fever.
Medicine (Baltimore),95(16):e3449 2016(Apr.)
Author:Koga T, Migita K, Sato S, Umeda M, Nonaka F, Kawashiri SY, Iwamoto N, Ichinose K, Tamai M, Nakamura H, Origuchi T, Ueki Y, Masumoto J, Agematsu K, Yachie A, Yoshiura K, Eguchi K, Kawakami A.


Nod2-Nodosome in a Cell-Free System: Implications in Pathogenesis and Drug Discovery for Blau Syndrome and Early-Onset Sarcoidosis.
ScientificWorldJournal,2016:2597376 2016
Author:Iwasaki T, Kaneko N, Ito Y, Takeda H, Sawasaki T, Heike T, Migita K, Agematsu K, Kawakami A, Morikawa S, Mokuda S, Kurata M, Masumoto J.


IL-18 serum concentration is markedly elevated in typical familial Mediterranean fever with M694I mutation and can distinguish it from atypical type.
Mod Rheumatol,26(2):315-7 2016
Author:Yamazaki T, Shigemura T, Kobayashi N, Honda K, Yazaki M, Masumoto J, Migita K, Agematsu K.


Increased Serum B Cell Activating Factor and a Proliferation-inducing Ligand Are Associated with Interstitial Lung Disease in Patients with Juvenile Dermatomyositis.
J Rheumatol,42(12):2412-8 2015(Dec.)
Author:Kobayashi N, Kobayashi I, Mori M, Sato S, Iwata N, Shigemura T, Agematsu K, Yokota S, Koike K.


Reconstituted AIM2 inflammasome in cell-free system.
J Immunol Methods,426:76-81 2015(Nov.)
Author:Kaneko N, Ito Y, Iwasaki T, Takeda H, Sawasaki T, Migita K, Agematsu K, Kawakami A, Morikawa S, Mokuda S, Kurata M, Masumoto J.


Cytomegalovirus Encephalitis in a Patient with Severe Combined Immunodeficiency.
J Clin Immunol,35(8):689-91 2015(Nov.)
Author:Motobayashi M, Shigemura T, Tanaka M, Kurata T, Kobayashi N, Agematsu K, Amano Y, Inaba Y, Koike K, Nakazawa Y.


A Case Report of Familial Mediterranean Fever Diagnosed Following the Total Knee Arthroplasty.
HSS J,11(3):278-80 2015(Oct.)
Author:Kawamura S, Agematsu K, Kawamura D, Kawamura G, Suzuki K, Minami M.


A Novel In-Frame Deletion in the Leucine Zipper Domain of C/EBPε Leads to Neutrophil-Specific Granule Deficiency.
J Immunol,195(1):80-6 2015(Jul.)
Author:Wada T, Akagi T, Muraoka M, Toma T, Kaji K, Agematsu K, Koeffler HP, Yokota T, Yachie A.


Subcutaneous abscess due to the basidiomycete Phellinus mori in a patient with chronic granulomatous disease.
Infection,43(3):371-5 2015(Jun.)
Author:Shigemura T, Nakazawa Y, Amano Y, Sudo A, Watanabe M, Kobayashi M, Kobayashi N, Koike K, Agematsu K, Nishimura K.


Clinical and laboratory features of fatal rapidly progressive interstitial lung disease associated with juvenile dermatomyositis.
Rheumatology (Oxford),54(5):784-91 2015(May)
Author:Kobayashi N, Takezaki S, Kobayashi I, Iwata N, Mori M, Nagai K, Nakano N, Miyoshi M, Kinjo N, Murata T, Masunaga K, Umebayashi H, Imagawa T, Agematsu K, Sato S, Kuwana M, Yamada M, Takei S, Yokota S, Koike K, Ariga T.


Identification of Disease-Promoting HLA Class I and Protective Class II Modifiers in Japanese Patients with Familial Mediterranean Fever.
PLoS One,10(5):e0125938 2015(May)
Author:Yasunami M, Nakamura H, Agematsu K, Nakamura A, Yazaki M, Kishida D, Yachie A, Toma T, Masumoto J, Ida H, Koga T, Kawakami A, Eguchi K, Furukawa H, Nakamura T, Nakamura M, Migita K.


Dysregulated mature IL-1β production in familial Mediterranean fever.
Rheumatology (Oxford),54(4):660-5 2015(Apr.)
Author:Migita K, Izumi Y, Fujikawa K, Agematsu K, Masumoto J, Jiuchi Y, Kozuru H, Nonaka F, Shimizu T, Nakamura T, Iwanaga N, Furukawa H, Yasunami M, Kawakami A, Eguchi K.


Dramatic Improvement in the Multifocal Positron Emission Tomography Findings of a Young Adult with Chronic Granulomatous Disease Following Allogeneic Hematopoietic Stem Cell Transplantation.
J Clin Immunol,35(1):84-6 2015(Jan.)
Author:Shigemura T, Nakazawa Y, Hirabayashi K, Kobayashi N, Sakashita K, Agematsu K, Koike K.


Successful treatment for West syndrome with severe combined immunodeficiency.
Brain Dev,37(1):140-4 2015(Jan.)
Author:Motobayashi M, Inaba Y, Fukuyama T, Kurata T, Niimi T, Saito S, Shiba N, Nishimura T, Shigemura T, Nakazawa Y, Kobayashi N, Sakashita K, Agematsu K, Ichikawa M, Koike K.


わが国における家族性地中海熱の臨床像
小児科,55:219-255 2014
Author:上松一永


Familial Mediterranean fever: genotype-phenotype correlations in Japanese patients
Medicine,93(3):158-164 2014
Author:Migita K, Agematsu K, Yazaki M, Nonaka F, Nakamura A, Toma T, Kishida D, Uehara R, Nakamura Y, Jiuchi Y, Masumoto J, Fukukawa H, Ida H, Terai C, Nakashima Y, Kawakami A, Nakamura T, Eguchi K, Yasunami M, Yachie A


Serum amyloid A induces NLRP-3-mediated IL-1beta secretion in neutrophils
PLoS One,9(5):e96703 2014
Author:Migita K, Izumi Y, Jiuchi Y, Kozuru H, Kawahara C, Nakamura M, Nakamura T, Agematsu K, Masumoto J, Yasumi M, Kawakami A, Eguchi K


Dramatic Improvement in the Multifocal Positron Emission Tomography Findings of a Young Adult with Chronic Granulomatous Disease Following Allogeneic Hematopoietic Stem Cell Transplantation
J Clin Immunol,35:84-86 2014
Author:Shigemura T, Nakazawa Y, Hirabayashi K, Kobayashi N, Sakashita K, Agematsu K, Koike K


Serial monitoring of Mucorales DNA load in serum samples of a patient with disseminated mucormycosis after allogeneic bone marrow transplantation
Int J Hematol,100:206-209 2014
Author:Shigemura T, Nakazawa Y, Matsuda K, Sano K, Yaguchi T, Motobayashi M, Saito S, Noda S, Kobayashi N, Agematsu K, Honda T, Koike K


Successful cord blood transplantation after repeated transfusions of unmobilized neutrophils in addition to antifungal treatment in an infant with chronic granulomatous disease complicated by invasive pulmonary aspergillosis
Transfusion,54:516-521 2014
Author:Shigemura T, Nakazawa Y, Yoshikawa K, Hirabayashi K, Saito S, Kobayashi N, Sakashita K, Shiohara M, Wada T, Shimodaira S, Agematsu K, Koike K


Clinical course in a patient with neutrophil-specific granule deficiency and rapid detection of neutrophil granules as a screening test
J Clin Immunol,34:780-783 2014
Author:Shigemura T, Yamazaki T, Shiohara M, Kobayashi N, Naganuma K, Koike K, Agematsu K


Defect of suppression of inflammasome-independent interleukin-8 secretion from SW982 synovial sarcoma cells by familial Mediterranean fever-derived pyrin mutations
Mol Bio Rep,41:545-553 2014
Author:Sugiyama R, Agematsu K, Migita K, Nakayama J, Mokuda S, Ogura F, Haraikawa K, Okumura C, Suehiro S, Morikawa S, Ito Y, Masumoto J


Markedly elevated CD64 expressions on neutrophils and monocytes are useful for diagnosis of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome during flares
Clin Rheumatol,33:677-683 2014
Author:Yamazaki T, Hokibara S, Shigemura T, Kobayashi N, Honda K, Umeda Y, Agematsu K


Acute pericarditis as the first manifestation of familial Mediterranean fever: a possible relationship with idiopathic recurrent pericarditis
Intern Med,53:1659-1663 2014
Author:Yoshioka K, Furumitsu Y, Sano T, Miyamoto T, Agematsu K


Rapid Detection of Intracellular p47phox and p67phox by Flow Cytometry; Useful Screening Tests for Chronic Granulomatous Disease.
J Clin Immunol,33:857-864 2013
Author:Wada T, Muraoka M, Toma T, Imai T, Shigemura T, Agematsu K, Haraguchi K, Moriuchi H, Oh-Ishi T, Kitoh T, Ohara O, Morio T, Yachie A.


Increased CD45RO(+) CD62L(+) CD4(+) T-cell subpopulation responsible for Th2 response in Kimura's disease
Hum Immunol,74:1097-1102 2013
Author:Yamazaki K, Kawashima H, Sato S, Tsunoda H, Yoshimura Y, Higuchi M, Hokibara S, Yamazaki T, Agematsu K.


The contribution of SAA1 polymorphisms to Familial Mediterranean fever susceptibility in the Japanese population.
PLoS One,8(2):e55227 2013
Author:Migita K, Agematsu K, Masumoto J, Ida H, Honda S, Jiuchi Y, Izumi Y, Maeda Y, Uehara R, Nakamura Y, Koga T, Kawakami A, Nakashima M, Fujieda Y, Nonaka F, Eguchi K, Furukawa H, Nakamura T, Nakamura M, Yasunami M.


Clinical relevance of MEFV gene mutations in Japanese patients with unexplained fever.
J Rheumatol.,(4):875-877 2012
Author:Migita K, Ida H, Moriuchi H, Agematsu K.


Clonal expansion of Epstein-Barr virus (EBV)-infected γδ T cells in patients with chronic active EBV disease and hydroa vacciniforme-like eruptions.
Int J Hematol.,96(4):443-449 2012
Author:Wada T, Toga A, Sakakibara Y, Toma T, Hasegawa M, Takehara K, Shigemura T, Agematsu K, Yachie A.


家族性地中海熱の臨床
日本臨床免疫学会会誌,34(7):355-360 2011
Author:右田清志, 上松一永


重村倫成, 小林法元, 中山佳子, 上松一永, 安井耕三, 小池健一. サリドマイドが著効した小児難治性腸管Behcet病の2例
胃と腸,46(2):1099-1104 2011
Author:重村倫成, 小林法元, 中山佳子, 上松一永, 安井耕三, 小池健一.


IL-21と原発性免疫不全症
炎症と免疫,19(3):223-227 2011
Author:上松一永.


IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells.
J Exp Med.,208(5):235-249 2011
Author:Saito M, Nagasawa M, Takada H, Hara T, Tsuchiya S, Agematsu K, Yamada M, Kawamura N, Ariga T, Tsuge I, Nonoyama S, Karasuyama H, Minegishi Y.


Quantification of κ-deleting recombination excision circles in Guthrie cards for the identification of early B-cell maturation defects.
J Allergy Clin Immunol.,28(3):223-225 2011
Author:Nakagawa N, Imai K, Kanegane H, Sato H, Yamada M, Kondoh K, Okada S, Kobayashi M, Agematsu K, Takada H, Mitsuiki N, Oshima K, Ohara O, Suri D, Rawat A, Singh S, Pan-Hammarström Q, Hammarström L, Reichenbach J, Seger R, Ariga T, Hara T, Miyawaki T, Nonoyama S.


Monitoring serum IL-18 levels is useful for treatment of a patient with systemic juvenile idiopathic arthritis complicated by macrophage activation syndrome.
Pediatr Rheumatol Online J.,9:15 2011
Author:Shigemura T, Yamazaki T, Hara Y, Ou JN, Stevens AM, Ochs HD, Koike K, Agematsu K.


A case of Behcet's disease associated with myelodysplastic syndrome involving trisomy 8 and a gain-of-function mutation in SHP-2.
Rheumatology.,(2):1342-1344 2011
Author:Shigemura T, Agematsu K, Yamazaki T, Sakashita K, Nakayama Y, Higuchi Y, Matsuda K, Koike K.


Potentiation of TLR9 responses for human naive B-cell growth through RP105 signaling
CLINICAL IMMUNOLOGY,135(1):125-136 2010
Author:Yamazaki, Kazuko; Yarnazaki, Takashi; Taki, Shinsuke; Miyake, Kensuke; Hayashi, Takuma; Ochs, Hans D.; Agematsu, Kazunaga


Femoral Osteomyelitis due to Cladophialophora arxii in a Patient with Chronic Granulomatous Disease
,37(5):469-473 2009
Author:Shigemura, T.; Agematsu, K.; Yamazaki, T.; Eriko, K.; Yasuda, G.; Nishimura, K.; Koike, K.


DNA double strand break repair enzymes function at multiple steps in retroviral infection
RETROVIROLOGY,6:114 2009
Author:Sakurai, Yasuteru; Komatsu, Kenshi; Agematsu, Kazunaga; Matsuoka, Masao

教育活動実績

授業等
2002 , 小児科学
2002 , 免疫学
2002 , 小児科学、免疫学