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谷口 俊一郎  タニグチ シユンイチロウ

教員組織電話番号0263-37-2679
教育組織医学部 医学科 包括的がん治療学FAX番号0263-37-2724
職名特任教授メールアドレスstangch@shinshu-u.ac.jp
住所〒390-8621 松本市旭3-1-1ホームページURLhttp://www.shinshu-u.ac.jp/faculty/medicine/department/doctor/grdkarei/i-bunshishuyo/

更新日:2021/09/21

プロフィール

研究分野
分子腫瘍学(がん転移 がん治療学  がんの微小環境)
現在の研究課題
がん転移の分子生物学的研究
キーワード:転移
細胞形態及び運動制御の分子生物学的研究

癌細胞の遺伝的不安定性と核マトリックス

アポトーシスと炎症:当研究室で見出したASCに着目して研究を進めている。

嫌気性菌を用いた固形癌の治療

所属学会
所属学会
米国癌学会
Metastasis Research Society

所属学会役職担当
日本癌学会 , 名誉会員
日本がん転移学会 , 名誉会員
日本がん分子標的治療学会 , 評議員
学歴
出身大学院
1978 , 九州大学 , 理学

出身学校・専攻等(大学院を除く)
1973 , 九州大学 , 理学部

取得学位
医学博士 , 日本
理学博士 , 日本
受賞学術賞
2015 , 第9回小林がん学術振興会 がん薬物療法に関する革新的治療法に対する助成及び表彰「固形がんの嫌気的微小環境を標的とした持続的抗腫瘍性物質産生系の開発」
1988 , 第7回日本癌学会奨励賞
研究職歴等
研究職歴
2012- , 疾患予防医科学系専攻 分子腫瘍学講座 教授
2003- , 信州大学大学院医学研究科加齢適応医科学系専攻 専攻長
1998- , 信州大学医学部加齢適応研究センターセンター長
1995- , 信州大学医学部加齢適応研究センター 教授
1987-1995 , 九州大学生体防御医学研究所 助教授
1978-1987 , 九州大学医学部 助手

研究活動業績

研究業績(著書・
発表論文等)
書籍等出版物
Tumor-Targeting Therapy UsingGene-Engineered Anaerobic-Nonpathogenic Bifidobacterium longum. Methods Mol Biol.
2016
Author:Taniguchi S, Shimatani Y, Fujimori M


10代からのいのち学 ーあるがん研究者のつぶやきー
オフィスエム 2012(Sep. 09)
Author:谷口俊一郎


細胞骨格に着目した癌転移の抑制ー癌細胞と宿主の両面からー, 門田守人,松浦成昭編:肝転移のすべて , 63-68
永井書店 2005
Author:谷口俊一郎


論文
Cecal Tumorigenesis in Aryl Hydrocarbon Receptor-Deficient Mice Depends on Cecum-Specific Mitogen-Activated Protein Kinase Pathway Activation and Inflammation
Am J Pathol,190(2):453-468 2020
Author:Matoba H, Takamoto M, Fujii C, Kawakubo M, Kasuga E, Matsumura T, Natori T, Misawa K, Taniguchi S, Nakayama J


Bidirectional crosstalk between neutrophils and adipocytes promotes adipose tissue inflammation
FASEB J,33(11):11821-11835 2019
Author:Watanabe Y, Nagai Y, Honda H, Okamoto N, Yanagibashi T, Ogasawara M, Yamamoto S, Imamura R, Takasaki I, Hara H, Sasahara M, Arita M, Hida S, Taniguchi S, Suda T, Takatsu K.


IL-1β Plays an Important Role in Pressure Overload-Induced Atrial Fibrillation in Mice
Biol Pharm Bull,42(4):543-546 2019
Author:Matsushita N, Ishida N, Ibi M, Saito M, Takahashi M, Taniguchi S, Iwakura Y, Morino Y, Taira E, Sawa Y, Hirose M.


Fascin1 Suppresses RIG-I-like Receptor Signaling and Interferon-β Production by Associating with IκB Kinase ϵ (IKK ϵ) in Colon Cancer
J Biol Chem,293(17):6326-6336 2018
Author:Matsumura T, Hida S, Kitazawa M, Fujii C, Kobayashi A, Takeoka M, Taniguchi SI, Miyagawa SI


Potential Role of ASC, a Proapoptotic Protein, for Determining the Cisplatin Susceptibility of Lung Cancer Cells
Tohoku J Exp Med,244(2):133-144 2018
Author:Sakaizawa T, Matsumura T, Fujii C, Hida S, Toishi M, Shiina T, Yoshida K, Hamanaka K, Ito KI, Taniguchi S


The eNOS-NO pathway attenuates kidney dysfunction via suppression of inflammasome activation in aldosterone-induced renal injury model mice
PLoS One,13(10):e0203823 2018
Author:Sogawa Y, Nagasu H, Itano S, Kidokoro K, Taniguchi S, Takahashi M, Kadoya H, Satoh M, Sasaki T, Kashihara N


ASC Induces Apoptosis via Activation of Caspase-9 by Enhancing Gap Junction-Mediated Intercellular Communication
PLoS One,12(1):e0169340 2017
Author:Kitazawa M, Hida S, Fujii C, Taniguchi S, Ito K, Matsumura T, Okada N, Sakaizawa T, Kobayashi A, Takeoka M, Miyagawa S


In situ delivery and production system of trastuzumab scFv with Bifidobacterium
Biochem Biophys Res Commun,493(1):306-312 2017
Author:Kikuchi T, Shimizu H, Akiyama Y, Taniguchi S


Novel role of ASC as a regulator of metastatic phenotype.
Cancer Med. 2016
Author:Okada N, Fujii C, Matsumura T, Kitazawa M, Okuyama R, Taniguchi S, Hida S.


The endothelial adrenomedullin-RAMP2 system regulates vascular integrity and suppresses tumour metastasis.
Cardiovasc Res. 2016
Author:Tanaka M, Koyama T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Liu T, Xian X, Imai A, Zhai L, Hirabayashi K, Owa S, Yamauchi A, Igarashi K, Taniguchi S, Shindo T.


Role of NLRP3 Inflammasomes for Rhabdomyolysis-induced Acute Kidney Injury.
2015
Author:Komada T, Usui F, Kawashima A, Kimura H, Karasawa T, Inoue Y, Kobayashi M, Mizushina Y, Kasahara T, Taniguchi S, Muto S, Nagata D, Takahashi M.


Excess aldosterone is a critical danger signal for inflammasome activation in the development of renal fibrosis in mice.
The FASEB Journal ,29:3899-3910 2015
Author: Kadoya H, Satoh M, Sasaki T, Taniguchi S, Takahashi M, Kashihara N


NLRP3 deficiency improves angiotensin II-induced hypertension but not fetal growth restriction during pregnancy.
Endocrinology,156(11):4281-4292 2015
Author:Shirasuna K, Karasawa T, Usui F, Kobayashi M, Komada T, Kimura A, Ohkuchi A, Taniguchi S, Takahashi M.


Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin Ⅱ-induced aortic aneurysm.
Arterioscler Thromb Vasc Biol.,35(1):127-136 2015
Author:Usui F, Shirasuna K, Kimura H, Tatsumi K, Kawashima A, Karasawa T, Yoshimura K, Aoki H, Tsutsui H, Noda T, Sagara J, Taniguchi S, Takahashi M


NFκB2 gene as a novel candidate that epigenetically responds to interval walking training.
Int J Sports Med.,36(9):769-775 2015
Author:Zhang Y, Hashimoto S, Fujii C, Hida S,Ito K, Matsumura T, Sakaizawa T, Morikawa M, Masuki S, Nose H, Higuchi K, Nakajima K, Taniguchi S


Nanosilica-induced placental inflammation and pregnancy complications: Different roles of the inflammasome components NLRP3 and ASC.
Nanotoxicology,9(5):554-567 2015
Author:Shirasuna1 K, Usui F , Karasawa T, Kimura H, Kawashima A, Hiroaki Mizukami H, Ohkuchi A, Nishimura S, Sagara J, Noda T, Ozawa K, Taniguchi S, Takahashi M


Phactr3/scapinin, a member of protein phosphatase 1 and actin regulator (phactr) family, interacts with the plasma membrane via basic and hydrophobic residues in the N-terminus.
PLoS One,9(11):e113289 2014
Author:Itoh A, Uchiyama A, Taniguchi S, Sagara J


ビフィズス菌を利用した固形がん治療の試み
Japanese Journal of Lactic Acid Bacteria,25:1 2014
Author:谷口俊一郎


ビフィズス菌を用いた抗がん剤開発
BIO INDUSTRY,31(5):43-48 2014
Author:谷口俊一郎


Nucleic acid sensing by T cells initiates Th2 cell differentiation.
Nat Commun,10:3566 2014
Author:Imanishi T, Ishihara C, Badr Mel S, Hashimoto-Tane A, Kimura Y, Kawai T, Takeuchi O, Ishii KJ, Taniguchi S, Noda T, Hirano H, Brombacher F, Barber GN, Akira S, Saito T


NLRP3 Regulates Neutrophil Functions and Contributes to Hepatic Ischemia-Reperfusion Injury Independently of Inflammasomes
J Immunol,192(9):4342-4351 2014
Author:Inoue Y, Shirasuna K, Kimura H, Usui F, Kawashima A, Karasawa T, Tago K, Dezaki, Nishimura S, Sagara J, Noda T, IwakuraY, Hiroko Tsutsui H, Taniguchi S, Yanagisawa K, Yada T, Yasuda Y, Takahashi M.


ASC in Renal Collecting Duct Epithelial Cells Contributes to Inflammation and Injury after Unilateral Ureteral Obstruction.
American Journal of Pathology,184(5):1287-1298 2014
Author:Komada T, Usui F, Shirasuna K, Kawashima A, Kimura H, Karasawa T, Nishimura S, Sagara J, Noda T, Taniguchi S, Muto S, Nagata D, Kusano E, Takahashi M


Effect of a cholesterol-rich lipid environment on the enzymatic activity of reconstituted hyaluronan synthase
Biochem. BiophysResCommun,443:666-671 2014
Author:Pawared Ontong, Hatada Y, Taniguchi S, Kakizaki I, Itano N


Beneficial innate signaling interference for antibacterial responses by a Toll-like receptor- mediated enhancement of the MKP-IRF3 axis.
Proc Natl Acad SciU SA,110(49):19884-19889 2013
Author:Negishi H, Matsuki K, Endo N, Sarashina H, Miki S, Matsuda A, Fukazawa K, Taguchi-Atarashi N, Ikushima H, Yanai H, Nishio J, Honda K, Fujioka Y, Ohba Y, Noda T, Taniguchi S, Nishida E, Zhang Y, Chi H, Flavell RA, Taniguchi T.


Clinical significance of apotosis-associated speck-like protein containing a caspase recruitment domain in oral squamous cell carcinoma.
Oral&Maxillofacial Pathology,115(6):799-809 2013
Author:Shimane T, Kobayashi H, Takeoka M, Kitazawa M, Matsumura T, Hida S, Tiepeng Xiao, Koike T, Taniguchi S, Kurita H.


Crucial Role of Hyaluronan in Neointimal Formation after Vascular Injury.
PLOS ONE.,8(3):e58760 2013
Author:Kashima Y, Takahashi M, Shiba Y, Itano N, Izawa A, Koyama J, Nakayama J, Taniguchi S, Kimata K, Ikeda U.


ASC-associated inflammation promotes cecal tumorigenesis in aryl hydrocarbon receptor- deficient mice.
Carcinogenesis.,34(1):1620-1627 2013
Author:Ikuta T, Kobayashi Y, Kitazawa M, Shiizaki K, Itano N, Noda T, Pettersson S, Poellinger L, Fujii-Kuriyama Y, Taniguchi S, Kawajiri K.


Critical role of caspase-1 in vascular inflammation and development of atherosclerosis in Western diet-fed apolipoprotein E-deficient mice.
Biochem Biophys Res Commun.,425:162-168 2012
Author:Usui F, Shirasuna K, Kimura H, Tatsumi K, Kawashima A, Karasawa T, Hida S, Sagara J, Taniguchi S,Takahashi M.


ASC plays a role in the priming phase of the immune response to type II collagen in collagen-induced arthritis.
Rheumatol Int.,Feb 18:Epub ahead of print 2011
Author:Yamazaki H, Takeoka M, Kitazawa M, Ehara T, Itano N, Kato H, Taniguchi S.


A novel role of Rho-kinase in the regulation of ligand-induced phosphorylated EGFR endocytosis via the early/late endocytic pathway in human fibrosarcomacells.
J Mol Histol.,42:427-442 2011
Author:Nishimura Y, Biborka Bereczky, Yoshioka K, Taniguchi S, Itoh K


Inflamasome Activation of Cardiac Fibroblasts IsEssential for MyocardialIschemia/Reperfusion Injury
Circulation.,123:594-604 2011
Author:Kawaguchi M, Takahashi M, Hata T, Kashima Y, Usui F, Izawa A, Takahashi Y, Masumoto J, Koyama J, Hongo M, Noda Tetsuo, Nakayama J, Sagara J, Taniguchi S, Ikeda U.


Effects of Anti-CD70 mAb on Theiler’s Murine Encephalomyelitis Virus-Induced Demyelinaiting Disease.
Brain Res.,4:236-245 2010
Author:Yanagisawa S, Takeichi N, Kaneyama T, Yagita H, Taniguchi S, Byung S.Kim, Chang-Sung Koh


Pathogenic Vibrio activated NLRP3 inflammasome via cytotoxins and TLR/NOD-Mediated NF-κB signaling.
J. Immunol.,184(9):5287-5297 2010
Author:Toma C, Higa N, Koizumi Y, Nakasone N, Ogura Y, McCoy AJ, Franchi L, Uematsu S, Sagara J, Taniguchi S, Tsutsui H, Akira S, Tschopp J, Núñez G, Suzuki T.


Anti-inflammatory activity of PYNOD and its mechanism in humans and mice.
J Immunol.,184(10):5874-5884 2010
Author:Imamura R, Wang Y, Kinoshita T, Suzuki M, Noda T, Sagara J, Taniguchi S, Okamoto H, Suda T.


Calponin h1-S175T Point Mutation Enhances Resistance to Actin Cytoskeleton Perturbation in Human CancerCells
ANTICANCER RES.,30:1071-1078 2010
Author:Sugaya A, Takeoka M, Itano N, Taguchi A, Ehara T, Taniguchi S.


Exercise Effects on Methylation of ASC Gene.
IntJ Sports Med.,31(9):671-675 2010
Author:Nakajima K, Takeoka M, Mori M, Hashimoto S, Sakurai A, Nose H, Higuchi K, Itano N,Shiohara M, Oh T, Taniguchi S.


Targeting solid tumors with non-pathogenic obligate anaerobic bacteria.
Cancer Sci.,101(9):1925-1932 2010
Author:Taniguchi S, Fujimori M, Sasaki T, Tsutsui H, Shimatani Y, Seki K, Amano J.


Hyaluronan Deficiency in Tumor Stroma Impairs Macrophage Trafficking and TumorNeovascularization.
Cancer Res.,70(18):7073-7083 2010
Author:Kobayashi N, Miyoshi S, Mikami T, Koyama H, Kitazawa M, Takeoka M, Sano K,Amano J, Isogai Z, Niida S, Oguri K, Okayama M, John A. McDonald, Kimata K, Taniguchi S, Itano N.


A Splice Variant of ASC Regulates IL-1β Release and Aggregates Differently from Intact ASC.
Mediators Inflamm.,2009:287387 2009
Author:Matsushita K, Takeoka M, Sagara J, Itano N, Kurose Y, Nakamura A, Taniguchi S.


Contribution of TIR domain-containing adapter inducing IFN-β mediated IL-18 Release to LPS-induced liver injury in mice.
,51:333-341 2009
Author:Imamura M, Tsutsui H, Yasuda K, Yumikura-Futatsugi S, Mitani K, Uchiyama R, Hayashi S, Akira S, Taniguchi S, Nico Van Rooijen, Jurg Tschopp,Yamamoto T, Fujimoto J, Nakanishi K.


Scapinin, the Protein Phosphatase 1 Binding Protein, Enhances Cell Spreading and Motility by Interacting with the Actin Cytoskeleton
Plos ONE,4(1):e4247 2009
Author:Sagara J, Arata T, Taniguchi S


Role of ASC in the Mouse Model ofHelicobacter pylori Infection.
J.Histochem&Cytochem.,57(4):327-338 2009
Author:Benoit BN, Kobayashi M, Kawakubo M,Takeoka M, Sano K, Zou J, Itano N, Tsutsui H, Noda T, Fukuda M, Nakayama J, Taniguchi S


Critical role of bone marrow apoptosis-associated speck-like protein, an inflammasome adaptor molecule, in neointimal formation after vascular injury inmice
Circulation.,117(24):3079-3087 2008
Author:Yajima N, Takahashi M, Morimoto H, Shiba Y, Takahashi Y, Masumoto J, Ise H,Sagara J, Nakayama J, Taniguchi S, Ikeda U


Reduction of Calponin h1 expression in human colon cancer blood vessels
European Journal of Surgical Oncology,34:531-537 2008
Author:Yanagisawa Y, Takeoka M, Ehara T, Itano N, Miyagawa S, Taniguchi S.


Significance of Tumor-Associated Stroma in Promotion of Intratumoral Lymphangiogenesis: Pivotal Role of a Hyaluronan-Rich Tumor Microenvironment
Am. J. Pathol,172:179-193 2008
Author:Koyama H, Kobayashi N, Harada M, Takeoka M, Kawai Y, Sano K, Fujimori M, Amano, J., Ohhashi, T., Kannagi, R., Kimata, K., Taniguchi, S., and Itano, N.


Metastasis-associated gene expression profile of liver and subcutaneous lesions derived from mouse pheochromocytoma cells.
Molecular Carcinogenesis,47:245-251 2008
Author:Ohta S, Taniguchi S, et al


Crosstalk between neovessels and mural cells directs the site-specific expression of
J. Cell Sci.,120(9):1607-1614 2007
Author:Yana I, Sagara H, Takaki S, Takatsu K, Nakamura K, Nakao K, Katsuki M, Taniguchi S, Aoki T, Sato H, Weiss SJ, Seiki M.


Exogeneous cytosine deaminase gene expression in bifidobacterium breve Ⅰ-53-8w for tumor-targeting enzyme/prodrug therapy
Biosci. Biotechnol. Biochem.,71(12):2921-2926 2007
Author:Hidaka A, Hamaji Y, Sasaki T, Taniguchi S, Fujimori M.


Regulatory molecules involved in inflammasome formation with special reference toa key mediator protein, ASC
Semin Immunopathol,29(3):231-238 2007
Author:Taniguchi S, SagaraJ


Development of spontaneous optic neuropathy in NF-kBp50-deficient mice; Requirement for NF-kBp50 in ganglion cell survival
Neuropath, Applied Neurobiol.,33(6):692-705 2007
Author:Takahashi Y, Katai N, Murata T, Taniguchi S, Hayashi T


In vitro expression of β-thalassemia gene(IVS1-1G>C) reveals complete inactivation of the normal5 splice site and alternative aberrant RNA splicing.
Ann Clin Biochem.,44(6):573-578 2007
Author:Fujihara N, Yamauchi K, Hirota-Kawadobora M,Ishikawa S,Tozuka M, Ishii E, Katsuyama T, Nobuo Okumura, Taniguchi S


Strong Enhancement of Recombinant Cytosine Deaminase Activity in Bifidobacterium longum for Tumor Targeting Enzyme-Prodrug Therapy.
Biosci. Biotechnol Biochem,71(4):874-883 2007
Author:Hamaji Y, Fujimori M, Sasaki T, MatsuhashiH, Matsui-Seki K, Shimatani-Shibata Y, Kano Y, Amano J, and Taniguchi S.


Translocation of Heparanase into Nucleus Results in Cell Differentiation.
Cancer Sci.,98(4):535-540 2007
Author:Nobuhisa T, Nakamoto Y, Okawa T, Takaoka M, Gundz M, Nagatsuka H, Tsujigiwa H, Shirakawa Y, Yamatsuji T, Haisa M, , Matsuoka J, Nakajima M, Taniguchi S, Sagara J, Dong J, and Tanaka N.


Hyperproduction of Hyaluronan in Neu-Induced Mammary Tumor Acceletrates Angiogenesis through Stromal Cell Recruitment: Possible Involvement of Versican/PG-M.
Am. J.Pathol.,170(3):1086-1099 2007
Author:KoyamaH; Hibi T; Isogai Z; Yoneda M;Fujimori M; Amano J; Kawakubo M; Kannagi R;Kimata K;Taniguchi S;Itano N.


Cryopyrin and pyrin activate caspase-1, but not NF-kappa B, via ASC oligomerization
CELL DEATH AND DIFFERENTIATION,13(2):236-249 2006
Author:Yu, JW; Wu, J; Zhang, Z; Datta, P; Ibrahimi, I; Taniguchi, S; Sagara, J; Fernandes-Alnemri, T; Alnemri, ES


Genetically engineered Bifidobacterium longum for tumor-targeting enzyme-prodrug therapy of autochthonous mammary tumors in rats
CANCER SCIENCE,97(7):649-657 2006
Author:Sasaki, T; Fujimori, M; Hamaji, Y; Hama, Y; Ito, K; Amano, J; Taniguchi, S


Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer
CANCER RESEARCH,66(12):6210-6218 2006
Author:Machida, EO; Brock, MV; Hooker, CM; Nakayama, J; Ishida, A; Amano, J; Picchi, MA; Belinsky, SA; Herman, JG; Taniguchi, S; Baylin, SB


Adenovirus-mediated Calponin h1 gene therapy directed against peritoneal dissemination of ovarian cancer: Bifunctional therapeutic effects on peritoneal cell layer and cancer cells
CLINICAL CANCER RESEARCH,12(17):5216-5223 2006
Author:Ogura, T; Kobayashi, H; Ueoka,Y; Okugawa, K; Kato, K; Hirakawa, T; Hashimoto, S; Taniguchi, S; Wake, N;Nakano,H


Animal models of pheochromocytoma including NIH initial experience
PHEOCHROMOCYTOMA,1073:300-305 2006
Author:Ohta, S; Lai, EW; Taniguchi, S; Tischler, AS; Alesci, S; Pacak, K


Genetically engineered bifidobacterium longum for tumor-targeting enzyme-prodrug therapy of breast cancer.
BREAST CANCER RESEARCH ANDTREATMENT,100:S77-S77 2006
Author:Fujimori, M; Sasaki, T; Hamaji, Y; Amano, J; Taniguchi, S


インターロイキン18(IL--)ーその作用と活性化機序
信州医誌,53:33-34 2005
Author:谷口俊一郎


特発性大腿骨頭壊死症におけるグルココルチコイド受容体の遺伝子多型性解析
別冊整形外科,48:51-53 2005
Author:堀内博志,五明広樹,中島滋郎,若林真司,斎藤直人,小林千益,縄田昌司,橋本博史,津田裕士,深沢 徹,谷口俊一郎,高岡邦夫


Suppression of cancer phenotypes through a multifunctional actin-binding protein, calponin, that attacks cancer cells and simultaneously protects the host from invasion
Cancer Science,96(11):738-746 2005
Author:Taniguchi, S


Role of charged and hydrophobic residues in the oligomerization of the PYRIN domain of ASC
Biochemistry,44(2):575-583 2005
Author:Moriya M, Taniguchi S, Peter Wu, Edvards Liepinsh, Gottfried Otting, Sagara J


QT PRODACT: evaluation of the potential of compounds to cause QT interval prolongation by action potential assays using guinea-pig papillary muscles
J Pharmacol Sci,99:449-457 2005
Author:Kii Y, Hayashi S, Tabo M, Shimosato T, Fukuda H, Itoh T, Amano H, Saito M, Morimoto H, YamadaK, Kanda A, Ishitsuka T,Yamazaki T, Kiuchi Y, Taniguchi S, Mori T, Shimizu S, Tsurubuchi Y, Yasuda S, Kitani S, Shimada C, Kobayashi K, Komeno M, Kasai C, Hombo T, Yamamoto K


QT PRODACT: a multi-site study of in vitro action potential assays on 21 compounds in isolated guinea-pig papillary muscles
J Pharmacol Sci,99:423-437 2005
Author:Hayashi S, Kii Y, Tabo M, Fukuda H, Itoh T, Shimosato T, Amano H, Saito M, Morimoto H, Yamada K, Kanda A, Ishitsuka T, Yamazaki T, Kiuchi Y, Taniguchi S, Mori T, Shimizu S, Tsurubuchi Y, Yasuda S, Kitani S, Shimada C, Kobayashi K, Komeno M, Kasai C, Hombo T, Yamamoto K


Dihydropyrimidine dehydrogenase expressionpredicts survival outcome and chemosensitivity to 5-fluorouracil in patients with oral squamous cell carcinoma
Oral Oncol,41(1):38-47 2005
Author:Kobayashi H, Koike T, Nakatsuka A, Kurita H, Sagara J, Taniguchi S, Kurashina K


新規アポトーシス制御蛋白ASC:インターロイキン変換酵素の新しい活性化経路
臨床免疫,42(3):306-312 2004
Author:相良淳ニ,谷口俊一郎


ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules
Genes to Cells,9(11):1055-1067 2004
Author:Yamamoto M, Yaginuma K, Tsutsui H, Sagara J, Guan X, Seki E, Yasuda K, Yamamoto M,AkiraS, Nakanishi K, Noda T, Taniguchi S


Selective expression and functional characteristics of three mammalian hyaluronan synthases in oncogenic malignant transformation
J Biol Chem,279(18):18679-18687 2004
Author:Itano N, Sawai T, Atsumi F, Miyaishi O, Taniguchi S, Kannagi R, Hamaguchi M, Kimata K


Clinical significance of cellular distribution of moesin in patients with oral squamous cell carcinoma
Clin Cancer Res,10(2):572-580 2004
Author:Kobayashi H, Sagara J, Kurita H, Morifuji M, Ohishi M, Kurashina K, Taniguchi S


H1カルポニン遺伝子欠損マウスにおける運動性ならびに摂食・飲水行動の増加(短報)(生理学)
The journal of veterinary medical science,65(1):153-155 2003
Author:坂内慎,善本亮,三井-斉藤みの里,堀正敏,西原真杉,高橋克仁,山村倫子,谷口俊一郎,勝木元也,尾崎博,唐木英明


Increased locomotor activity, increased food and water intake and decreased PVN neurons in H1 calponin gene-deficient mice
JOURNAL OF VETERINARYMEDICALSCIENCE,65(1):153-155 2003
Author:Bannai, M; Yoshimoto, R; Mitsui-Saito, M; Hori, M; Nishihara, M; Takahashi, K; Yamamura, H; Taniguchi, S; Katsuki, M; Ozaki, H; Karaki, H


Caspy, a zebrafish caspase, activated by ASC oligomerization is required for pharyngeal arch development
JOURNAL OF BIOLOGICAL CHEMISTRY,278(6):4268-4276 2003
Author:Masumoto, J; Zhou, WB; Chen, FF; Su, FY; Kuwada, JY; Hidaka, E; Katsuyama,T; Sagara, J; Taniguchi, S;Ngo-Hazelett, P; Postlethwait, JH;Nunez, G; Inohara, N


Enhanced baroreflex sensitivity in free-moving calponin knockout mice
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY,284(3):H939-H946 2003
Author:Masuki, S; Takeoka, M; Taniguchi, S; Nose, H


ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,303(1):69-73 2003
Author:Masumoto, J; Dowds, TA; Schaner, P; Chen, FF; Ogura, Y; Li, M; Zhu, L; Katsuyama, T; Sagara, J; Taniguchi, S; Gumucio, DL;Nunez, G; Inohara, N


Impaired arterial pressure regulation during exercise due to enhancedmuscular vasodilation in calponin knockout mice
FASEB JOURNAL,17(4):A431-A431 2003
Author:Masuki, S; Takeoka, M; Taniguchi, S; Nose, H


Shifts in cellular localization of moesin in normal oral epithelium, oral epithelial dysplasia, verrucous carcinoma and oral squamous cell carcinoma
JOURNAL OF ORAL PATHOLOGY&MEDICINE,32(6):344-349 2003
Author:Kobayashi, H; Sagara, J; Masumoto, J; Kurita, H; Kurashina, K; Taniguchi, S


Reduced expression of actin-binding proteins, h-caldesmon and calponin h1, in the vascular smooth muscle inside melanoma lesions: an adverse prognostic factor for malignant melanoma
BRITISH JOURNAL OF DERMATOLOGY,148(5):971-980 2003
Author:Koganehira, Y; Takeoka, M; Ehara, T; Sasaki, K; Murata, H; Saida, T; Taniguchi, S


ASC/TMS1, A caspase-1 activating adaptor, is downregulated by aberrant methylation in human melanoma
INTERNATIONAL JOURNAL OF CANCER,107(2):202-208 2003
Author:Guan, X; Sagara, J; Yokoyama, T; Koganehira, Y; Oguchi, M; Saida, T; Taniguchi, S


Suppression of peritoneal dissemination through protecting mesothelial cells from retraction by cancer cells
INTERNATIONAL JOURNAL OF CANCER,107(4):557-563 2003
Author:Hashimoto, S; Takeoka, M; Taniguchi, S


Impaired arterial pressure regulation during exercise dueto enhanced muscular vasodilatation in calponin knockout mice
JOURNAL OF PHYSIOLOGY-LONDON,553(1):203-212 2003
Author:Masuki, S; Takeoka, M; Taniguchi, S; Yokoyama, M; Nose, H


Methylation of ASC/TMS1, a proapoptotic gene responsible for activating procaspase-1, in human colorectal cancer
CANCER LETTERS,202(1):101-108 2003
Author:Yokoyama, T; Sagara, J; Guan, X; Masumoto, J; Takeoka, M; Komiyama, Y; Miyata, K; Higuchi, K; Taniguchi, S


Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure
J Biol Chem,278(46):45611-45619 2003
Author:Sagara J, Higuchi T, Hattori Y, Moriya M, Sarvotham H, Shima H, Shirato H, KikuchiK,Taniguchi S


Apoptosis-associated speck-like protein is associated with inflammation and apoptosis in liver withhepatitis C infection.
HEPATOLOGY,36(4):270A-270A 2002
Author:Soeda, J; Miyagawa, S; Sagara, J; Sano, K; Masumoto, J; Ichikawa, E; Taniguchi, S; Kawasaki, S


Antitumor efficacy of anaerobic bacteria as delivery system for breast cancer gene therapy.
BREAST CANCER RESEARCH AND TREATMENT,76:S100-S100 2002
Author:Fujimori, M; Sasaki, T; Nakamura, T; Amano, J; Taniguchi, S


Calponin H1 induced a flattened morphology and suppressed the growth of human fibrosasrcoma HT1080 cells
Eur J Cancer,38(3):436-442 2002
Author:Takeoka M, Ehara T, Hashimoto S, Taniguchi S


Expression of lamins depends on epidermal differentiation and transformation
Brit.J. Dermatology,147(5):1-6 2002
Author:Oguchi M, Sagara J, Matsumoto K, Saida T, Taniguchi S


Inhibition of urokinase-type plasminogen activator delays expression of c-jun, activated transforming growth factor beta 1, and matrix metalloproteinase 2 during post-hepatectomy liver regenerationin mice
J Hepatology,36(5):637-644 2002
Author:Nomura K, Miyagawa S, Ayukawa K, Soeda J, Taniguchi S, Kawasaki S


Cloned cytosine deaminase gene expression of bifidobacterium longum and application to enzyme/pro-drug therapy of hypoxic solid tumors
Biosci Biotechnol Biochem,66(11):2362-2366 2002
Author:Nakamura T, Sasaki T, Fujimori M, Yazawa K, Kano Y, Amano J, Taniguchi S


The genus Bifidobacterium for cancer gene therapy
Current Opinion In Drug Discovery&Development,5(2):200-203 2002
Author:Fujimori M, Amano J, Taniguchi S


ASC, which is composed of a PYD and a CARD, is up-regulated by inflammation and apoptosis in human neutrophils
Biochem Biophys Res Commun,293(5):1314-1318 2002
Author:Shiohara M, Taniguchi S, Masumoto J, Yasui K, Koike K, Komiyama A, Sagara J


Calponin h1 suppresses tumor growth of src-induced transformed 3Y1 cells in association with a decrease in angiogenesis.
Jpn J Cancer Res,93(8):935-943 2002
Author:Kaneko M, Takeoka M, Oguchi M, Koganehira Y, MurataH, Ehara T, Tozuka M, Saida T, Taniguchi S


Murine ortholog of ASC, a CARD-containing protein, self-associates and exhibits restricteddistribution in developing mouse embryos
EXPERIMENTAL CELL RESEARCH,262(2):128-133 2001
Author:Masumoto, J; Taniguchi, S; Nakayama, K; Ayukawa, K; Sagara, J


Pyrin N-terminal homology domain- and caspase recruitment domain-dependent oligomerization of ASC
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,280(3):652-655 2001
Author:Masumoto, J; Taniguchi, S; Sagara, J


Bifidobacterium longum as a delivery system for gene therapy of chemically induced rat mammary tumors
BREAST CANCER RESEARCH AND TREATMENT,66(2):165-170 2001
Author:Yazawa, K; Fujimori, M; Nakamura,T; Sasaki, T; Amano, J; Kano, Y; Taniguchi, S


Close relation of reduced expression of actin-binding proteins, calponin-h1 and h-caldesmon, in the vascular smoothmuscle inside human malignant melanoma with the poor prognosis
JOURNAL OF INVESTIGATIVE DERMATOLOGY,117(2):393-393 2001
Author:Koganehira, Y; Takeoka, T; Ehara, T; Hashimoto, S; Murata, H; Saida, T; Taniguchi,S


Expression of apoptosis-associated speck-like protein containing a caspaserecruitment domain, a pyrin N-terminal homology domain-containing protein, in normal human tissues
JOURNAL OF HISTOCHEMISTRY&CYTOCHEMISTRY,49(10):1269-1275 2001
Author:Masumoto, J; Taniguchi, S; Nakayama, J; Shiohara, M; Hidaka, E; Katsuyama, T; Murase, S;Sagara, J


Urokinase-type plasminogen activator initiates expression of c-jun, activated transforming growth factor beta 1, and matrix metalloproteinase 2 during post-hepatectomy liver regeneration in mice.
HEPATOLOGY,34(4):387A-387A 2001
Author:Nomura, K; Miyagawa, S; Ayukawa, K; Soeda, J; Taniguchi, SI; Kawasaki, S


Initiation of apoptotic cascade during warm ischemia in rat liver.
HEPATOLOGY,34(4):275A-275A 2001
Author:Soeda, J; Miyagawa, S; Sano, K; Masumoto, S; Taniguchi, S; Kawasaki, S


Cytochrome c release into cytosol with subsequent caspase activation during warm ischemia in rat liver
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY,281(4):G1115-G1123 2001
Author:Soeda, J; Miyagawa, S; Sano, K; Masumoto, J; Taniguchi, S; Kawasaki, S


Dynamic DNA methylation change in the CpGisland region of p15 during human myeloid development
JOURNAL OF CLINICAL INVESTIGATION,108(8):1195-1204 2001
Author:Sakashita, K; Koike, K; Kinoshita, T; Shiohara, M; Kamijo, T; Taniguchi, S; Kubota, T


Bifidobacterium longum as a delivery system for gene therapy of chemically induced rat mammary tumors.
BREAST CANCER RESEARCH AND TREATMENT,69(3):256-256 2001
Author:Fujimori, M; Nakamura, T; Sasaki, T; Hama, Y; Amano, J; Taniguchi, S


ASC, which is composed of a pyrin-N-terminal homology domain and a caspase-recruitment domain, is up-regulated by inflammation and apoptosis in human neutrophils.
BLOOD,98(11):229A-229A 2001
Author:Shiohara, M; Taniguchi, S; Masumoto, J; Yasui, K; Koike, K; Komiyama, A; Sagara, J


Structural fragility of blood vessels and peritoneum in calponin h1-deficientmice, resulting in an increase in hematogenous metastasis and peritoneal dissemination of malignant tumor cells
CANCER RESEARCH,61(20):7627-7634 2001
Author:Taniguchi, S; Takeoka, M; Ehara, T; Hashimoto, S; Shibuki, H; Yoshimura, N; Shigematsu, H; Takahashi, K; Katsuki, M


Bifidobacterium longum as a delivery system for cancer gene therapy: Selective localization and growth in hypoxic tumors
CANCER GENE THERAPY,7(2):269-274 2000
Author:Yazawa, K; Fujimori, M; Amano, J; Kano, Y; Taniguchi, S


Sequential chemoimmunotherapy with cisplatin, interferon-beta and interleukin-2 inhibits the growth of B16-F1 melanoma in syngeneic mice
MELANOMA RESEARCH,10(3):223-229 2000
Author:Kubo, H; Matsumoto, K; Funahashi, M; Takagi, H; Kitajima, Y; Taniguchi, S; Saida, T


Human malignant melanoma cells release a factor that inhibits the expressionof smooth muscle alpha-actin
JOURNAL OF DERMATOLOGICAL SCIENCE,23(3):170-177 2000
Author:Okamoto-Inoue, M; Nakayama, J; Hori, Y; Taniguchi, S


Regulation of shortening velocity by calponin in intact contracting smooth muscles
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,279(1):150-157 2000
Author:Takahashi, K; Yoshimoto, R; Fuchibe, K; Fujishige, A; Mitsu-Saito, M; Hori, M; Ozaki, H; Yamamura, H; Awata, N; Taniguchi, S; Katsuki, M; Tsuchiya, T; Karaki, H


Ca2+-sensitization of contraction in the h1 calponin-deficient smooth muscle
JAPANESE JOURNAL OF PHARMACOLOGY,84(4):474-475 2000
Author:Yoshimoto, R; Hori, M; Takahashi, K; Taniguchi, S; Katsuki, M; Ozaki, H; Karaki, H


Contractile properties and proteins of smooth muscles of a calponin knockout mouse
JOURNAL OF PHYSIOLOGY-LONDON,529(3):811-824 2000
Author:Matthew, JD; Khromov, AS; McDuffie, MJ; Somlyo, AV; Somlyo, AP; Taniguchi, S; Takahashi, K


Bifidobacterium longum as a delivery system for cancer gene therapy: selective localization and growth in hypoxic tumors
Cancer Gene Therapy,7(2):269-274 2000
Author:K Yazawa, M Fujimori, J Amano, Y Kano, S Taniguchi


La autoantigen is cleaved in the COOH terminus and loses the nuclear localization signal during apoptosis
JOURNALOF BIOLOGICAL CHEMISTRY,275(44):34465-34470 2000
Author:Ayukawa, K; Taniguchi, S; Masumoto, J; Hashimoto, S; Sarvotham, H; Hara, A;Aoyama, T; Sagara, J


Promoted dermal fibrosis during wound healing in calponin h 1 (CNhl)-deleted mice
JOURNAL OF INVESTIGATIVE DERMATOLOGY,112(4):583-583 1999
Author:Takeoka, M; Ehara, T; Murata, H; Saida, T; Katsuki,M; Takahashi, K; Taniguchi, S


Reduced expression of an actin binding protein, calponin h 1 (CNh1), in blood vessels of human malignant skin tumors
JOURNAL OFINVESTIGATIVE DERMATOLOGY,112(4):569-569 1999
Author:Koganehira, Y; Ehara, T; Takeoka, M; Saida, T; Taniguchi, S


Inhibitory effects of roxithromycin on tumor angiogenesis, growth and metastasis of mouse B16 melanoma cells
CLINICAL&EXPERIMENTAL METASTASIS,17(2):119-124 1999
Author:Yatsunami, J; Tsuruta, N; Fukuno, Y; Kawashima,M; Taniguchi, S; Hayashi, S


The induction of smooth muscle alpha actin in a transformed rat cell line suppresses malignant properties in vitro and in vivo
CANCER LETTERS,142(2):173-178 1999
Author:Okamoto-Inoue, M; Kamada, S; Kimura, G; Taniguchi, S


Antiangiogenic and antitumor effects of 14-membered ring macrolides on mouse B16 melanoma cells
CLINICAL&EXPERIMENTAL METASTASIS,17(4):361-367 1999
Author:Yatsunami, J; Fukuno, Y; Nagata, M; Tominaga, M; Aoki, S; Tsuruta, N; Kawashima, M; Taniguchi, S; Hayashi, S


Roxithromycin and clarithromycin, 14-membered ring macrolides, potentiate the antitumor activity of cytotoxic agents against mouse B16melanoma cells
CANCER LETTERS,147(1-2):17-24 1999
Author:Yatsunami, J; Fukuno, Y; Nagata, M; Tsuruta, N; Aoki, S; Tominaga, M; Kawashima, M; Taniguchi, S; Hayashi, S


Increased synthesis of hyaluronate enhances motility of human melanoma cells
JOURNAL OF INVESTIGATIVE DERMATOLOGY,113(6):935-939 1999
Author:Ichikawa, T; Itano, N; Sawai, T; Kimata, K; Koganehira, Y; Saida, T; Taniguchi, S


Possible role of calponin h1 as a tumor suppressor in human uterine leiomyosarcoma
JOURNAL OF THE NATIONAL CANCER INSTITUTE,91(9):790-796 1999
Author:Horiuchi, A; Nikaido, T; Taniguchi, S; Fujii, S


ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells
JOURNAL OF BIOLOGICAL CHEMISTRY,274(48):33835-33838 1999
Author:Masumoto, J; Taniguchi, S; Ayukawa, K; Sarvotham, H; Kishino, T; Niikawa, N; Hidaka, E; Katsuyama, T; Higuchi, T; Sagara, J


Moesin and CD44 expression in cutaneous melanocytic tumours
BRITISH JOURNAL OFDERMATOLOGY,138(5):763-768 1998
Author:Ichikawa, T; Masumoto, J; Kaneko, M; Saida, T; Sagara, J; Taniguchi, S


Targeted disruption of calponin results in rapid crossbridge cycling and reduced force in phasic smooth muscle
BIOPHYSICAL JOURNAL,74(2):A38-A38 1998
Author:Takahashi, K; Mitsui-Saito, M; Fuchibe, K; Yamamura, H; Taniguchi, S; Katsuki, M; Ozaki, H; Tsuchiya, T; Shibata, N; Karaki, H


Differential expression of moesin in cells of hematopoietic lineage and lymphatic systems
HISTOCHEMISTRY AND CELL BIOLOGY,110(1):33-41 1998
Author:Masumoto,J; Sagara, J; Hayama, M; Hidaka, E; Katsuyama, T; Taniguchi, S


Expression of moesin and its associated molecule CD44 in epithelial skin tumors
JOURNAL OF CUTANEOUS PATHOLOGY,25(5):237-243 1998
Author:Ichikawa, T; Masumoto, J; Kaneko, M; Saida, T; Sagara, J; Taniguchi, S


Reduced expression of calponin h1 in leiomyosarcoma of the uterus
LABORATORY INVESTIGATION,78(7):839-846 1998
Author:Horiuchi, A; Nikaido, T; Ito, K;Zhai, YI; Orii, A; Taniguchi, S; Toki, T; Fujii, S


Augmentation in the expression of a ribosomal protein associated with transformation
BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL,46(3):629-638 1998
Author:Go, H; Taniguchi, S


Genomic structure of the human ribosomalprotein L41 gene
BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL,46(6):1227-1231 1998
Author:Go, H; Miyado, K; Taniguchi, S


Mice lackingsmooth muscle calponin display increased bone formation that is associated with enhancement of bone morphogenetic protein responses
GENES TO CELLS,3(10):685-695 1998
Author:Yoshikawa, H; Taniguchi, S; Yamamura, H; Mori, S; Sugimoto, M; Miyado, K; Nakamura, K; Nakao, K; Katsuki, M; Shibata, N; Takahashi, K


A BALB/c 3T3-transformed cell line suitable for transfection assay of metastasis-inducing genes
INTERNATIONAL JOURNAL OF CANCER,71(1):88-93 1997
Author:Tatsuka, M; Ota, T; Maeda, M; Wada, M; Yamagishi, N; Taniguchi, S;Seiki, M; Odashima, S


Transformation-related expression of a low-molecular-mass tropomyosinisoform TM5/TM30nm in transformed rat fibroblastic cell lines
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,123(6):331-336 1997
Author:Miyado, K; Sato, M; Taniguchi, S


Suppression of pulmonary metastasis in murine B16 melanoma cells by transfection of a sialidase cDNA
INTERNATIONAL JOURNAL OFCANCER,73(3):410-415 1997
Author:Tokuyama, S; Moriya, S; Taniguchi, S; Yasui, A; Miyazaki, J; Orikasa, S; Miyagi, T


Dibutyryl cAMP inhibits endotoxin-induced increases in pulmonary vascular resistance and fluid filtration coefficient in the perfused rat lung
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE,183(4):273-284 1997
Author:Takeoka, M; Sakai, A; Ueda, G; Ge, RL; Ishizaki, T; Panos, RJ; Taniguchi, S


Decreased expression of a single tropomyosin isoform, TM5/TM30nm, results in reduction in motility of highly metastatic B16-F10 mouse melanoma cells
BIOCHEMICAL AND BIOPHYSICAL RESEARCHCOMMUNICATIONS,225(2):427-435 1996
Author:Miyado, K;Kimura, M; Taniguchi, S


Influence of hypoxia and pulmonary air embolism on lung injury in perfused rat lungs
RESPIRATION,63(6):346-351 1996
Author:Takeoka, M; Sakai, A; Ueda, G;Ge, RL; Panos, RJ; Taniguchi, S


MISC
嫌気性菌をがんへの”運び屋”にする
科学,:0219 2011
Author:谷口俊一郎


ビフィズス菌を用いた固形がんの治療     ー 低酸素環境を標的とする選択的デリバリー ー
化学と生物,48(10):671-673 2010
Author:谷口俊一郎


嫌気性菌を用いた固形癌の治療
実験医学,27(2):191-196 2009
Author:谷口俊一郎

研究費
受託研究
2012 - 2013 , 低酸素環境を標的とするビフィズス菌を用いた新規治療薬の研究開発
2011 - 2011 , 固形がんの低酸素環境を標的とするビフィズス菌を用いた抗がん剤の研究開発
2010 - 2010 , ビフィズス菌を用いた抗がん剤プラットフォーム技術の開発
2008 - 2008 , ビフィズス菌を用いた抗がん剤プラットフォーム技術の開発
2006 - 2008 , 遺伝子組み換えビフィドバクテリウムに関する研究

科学研究費補助金(研究代表者)
2018 - 2020 , ビフィズス菌を用いた固形がん選択的抗がん分子産生系の効率・安全性改善 , 基盤研究(C)
2015 - 2017 , 抗腫瘍性物質の腫瘍内持続的産生を目指す基盤研究 , 基盤研究(C)
2011 - 2013 , Inflamasome形成に関わるASCの多面的機能の解析 , 基盤研究(C)
2008 - 2009 , 自然免疫制御因子ASCによるATP代謝制御とオートファジーに伴う細胞死の制御 , 特定領域研究
2007 - 2008 , 炎症と細胞死を制御するASCに着目したピロリ菌感染と宿主応答の解析 , 基盤研究(C)

科学研究費補助金(研究分担者)
2014 - , 臓器間連携と恒常性を司る新しい生体内情報制御システムの解明と応用展開 , 基盤研究(B)
2013 - 2015 , 運動療法によって変動するエピジェネティック分子の網羅的解析と予防医学の意義 , 基盤研究(C)
2013 - 2014 , 加齢による体温調節能劣化機構の解明とその熱中症予防への応用 , 基盤研究(A)

奨学寄附金
2015 , 固形がんの嫌気的微小環境を標的とした持続的抗腫瘍性物質産生系の開発

教育活動実績

授業等
2016 , 科学論
2016 , 生化学・分子生物学研究方法特論
2016
2016 , 腫瘍学研究方法特論
2015 , 疾患予防医科学概論
2015 , 科学論
2014 , 臨床腫瘍学
2013 , 前期 , 生化学・分子生物学研究方法特論
2013 , 後期 , 腫瘍学研究方法特論
2013 , 後期 , ヒト生物学Ⅱ
2012 , 科学論
2012 , 分子腫瘍学
2012 , 前期 , 臨床腫瘍学
2012 , 前期 , 生化学・分子生物学研究方法特論
2012 , 後期 , ヒト生物学Ⅱ
2012 , 後期 , 腫瘍学研究方法特論
2011 , 分子腫瘍学
2011 , 分子細胞学研究特論
2011 , 前期 , 臨床腫瘍学
2011 , 前期 , ヒト生物学Ⅲ
2011 , 前期 , 生化学・分子生物学研究方法特論
2011 , 後期 , ヒト生物学Ⅱ
2011 , 後期 , 科学論
2011 , 後期 , 腫瘍学研究方法特論

社会活動実績

社会活動等
公開講座
2013.7.12 - 2013.7.12 , 山極勝三郎博士 生誕150周年記念シンポジウム・市民公開講座
2011.3.26 - , 第7回加齢適応医科学系専攻公開シンポジウム・市民公開講座
2010.2.20 - , 第6回加齢適応医科学系専攻公開シンポジウム・市民公開講座
2009.2.15 - , 第5回加齢適応医科学系専攻公開シンポジウム・市民公開講座
2008.1.27 - , 第4回加齢適応医科学系専攻公開シンポジウム・市民公開講座
2007.1.27 - , 第3回加齢適応医科学系専攻公開シンポジウム・市民公開講座

講演会
2013.10.10 - 2013.10.10 , がん教育「ドクタービジット」
20061110 - , 研究の面白さ

学会・研究会の主催
2013.7.11 - 2013.7.12 , 第22回日本がん転移学会学術集会・総会 , 会長

メディア・報道
2013.7.15 , 松本市民タイムス , 第22回日本がん転移学会学術集会・総会において市民公開のシンポジウムを開催
2013.10.30 , 日刊工業新聞 , ビフィズス菌で抗がん剤運ぶ
2013.10.11 , 朝日新聞 , 長野清泉女学院高校において「ドクタービジット」が開催された。
2012.2.19 , 読売新聞 , 産業革新機構、アネロファーマサイエンスに追加出資
2011.12.31 , 信濃毎日新聞 , アネロファーマサイエンスのがん治療法の臨床試験を米国で来春より開始
2010.9.30 , 信濃毎日新聞 , アネロファーマサイエンスの抗がん剤、エーザイと交渉権契約
2010.11.2 , 信濃毎日新聞 , 産業革新機構、アネロファーマサイエンスに出資
2009.11.30 , 日経産業新聞 , ビフィズス菌でがん直撃(アネロフォーマサイエンス)
20060821 , 日本経済新聞 , がん治療 ビフィズス菌利用
20040902 , 日本経済新聞 , アネロファーマ・サイエンス設立
大学発ベンチャー
2004 , アネロファーマサイエンス , 取締り役 , 研究