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垣野明美  カキノ アケミ

教員組織学術研究院(医学系)電話番号
教育組織医学部 医学科 生理学FAX番号
職名助教メールアドレス
住所〒390-8621 長野県松本市旭3-1-1ホームページURL

プロフィール

兼担研究科・学部
医学部 医学科 生理学
先鋭領域融合研究群 バイオメディカル研究所 バイオテクノロジー・生体医工学部門
研究分野
分子病態生理学
血管生物学
所属学会
所属学会
日本生化学会
日本生理学会
日本薬理学会
日本動脈硬化学会
日本分子生物学会
日本循環薬理学会
日本心血管内分泌代謝学会
高血圧関連疾患モデル学会
学歴
取得学位
博士(薬学) , 大阪大学
受賞学術賞
2017 , アクテリオン アカデミアプライズ2017
2016 , 68th AACC Annual Scientific Meeting Lipoproteins and Vascular Diseases Division Abstract Award
2013 , 第23回日本循環薬理学会 Young Investigator Award
2013 , 第17回日本心血管内分泌代謝学会 若手研究奨励賞
2013 , 第86回日本生化学会 鈴木紘一メモリアル賞
2012 , 第8回宮崎サイエンスキャンプ ヤング優秀賞
2012 , 第85回日本薬理学会年会 優秀発表賞
研究職歴等
研究職歴
2015- , 信州大学先鋭領域融合研究群バイオメディカル研究所 助教
2012-2015 , 国立循環器病研究センター 研究員
2008-2012 , 国立循環器病研究センター 特任研究員
2007-2008 , 国立循環器病研究センター 流動研究員

研究活動業績

研究業績(著書・
発表論文等)
論文
123I-labeled oxLDL is widely distributed throughout the whole body in mice.
Nucl Med Mol Imaging,52:144-153 2018
Author:Nakano, A., Kawashima, H., Miyake, Y., Zeniya, T., Yamamoto, A., Koshino, K., Temma, T., Fukuda, T., Fujita, Y., Kakino, A., Kanaya, S., Sawamura, T. and Iida, H.


L5: An LDL fraction in which pathogenic activity of LDL is concentrated.
Trends Cardiovasc Med,27:247-248 2017
Author:Sawamura, T., Fujita, Y., Horiuchi, S., Kakino, A.


LOX-1 in ischemic stroke.
J Atheroscler Thromb,24:566-568 2017
Author:Sawamura, T., Fujita, Y., Horiuchi, S., Kakino, A.


Deletion of LOX-1 protects against heart failure induced by doxorubicin.
PLoS One,11:e0154994 2016
Author:Yokoyama, C., Aoyama, T., Ido, T., Kakino, A., Shiraki, T., Tanaka, T., Nishigaki, K., Hasegawa, A., Fujita, Y., Sawamura, T. and Minatoguchi, S.


High levels of soluble lectin-like oxidized low-density lipoprotein receptor-1 in acute stroke: An age- and sex-matched cross-sectional study.
J Atheroscler Thromb,23:1222-1226 2016
Author:Yokota, C., Sawamura, T., Watanabe, M., Kokubo, Y., Fujita, Y., Kakino, A., Nakai, M., Toyoda, K., Miyamoto, Y. and Minematsu, K.


Developmental endothelial locus-1 (Del-1) inhibits oxidized low-density lipoprotein activity by direct binding, and its overexpression attenuates atherogenesis in mice.
Circ J,80:2541-2549 2016
Author:Kakino, A., Fujita, Y., Nakano, A., Horiuchi, S. and Sawamura, T.


Lectin-like oxidized low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state.
Bone,75:170-182 2015
Author:Nakayachi, M., Ito, J., Hayashida, C., Ohyama, Y., Kakino, A., Okayasu, M., Sato, T., Ogasawara, T., Kaneda, T., Suda, N., Sawamura, T. and Hakeda, Y.


Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor.
FASEB J,29:3342-3356 2015
Author:Yamamoto, K., Kakino, A. (co-first author), Takeshita, H., Hayashi, N., Li, L., Nakano, A., Hanasaki-Yamamoto, H., Fujita, Y., Imaizumi, Y., Toyama-Yokoyama, S., Nakama, C., Kawai, T., Takeda, M., Hongyo, K., Oguro, R., Maekawa, Y., Itoh, N., Takami, Y., Onishi, M., Takeya, Y., Sugimoto, K., Kamide, K., Nakagami, H., Ohishi, M., Kurtz, T.W., Sawamura, T. and Rakugi, H.


LOX-1 ligands containing apolipoprotein B and carotid intima-media thickness in middle-aged community-dwelling US Caucasian and Japanese men.
Atherosclerosis,229:240-245 2013
Author:Okamura, T., Sekikawa, A., Sawamura, T., Kadowaki, T., Barinas-Mitchell, E., Mackey, R.H., Kadota, A., Evans, R.W., Edmundowicz, D., Higashiyama, A., Nakamura, Y., Abbott, R.D., Miura, K., Fujiyoshi, A., Fujita, Y., Murakami, Y., Miyamatsu, N., Kakino, A., Maegawa, H., Murata, K., Horie, M., Mitsunami, K., Kashiwagi, A., Kuller, L.H., Ueshima, H. and Group, E.J.S.


Lectin-like oxidized low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis.
Arthritis Rheum,64:1024-1034 2012
Author:Ishikawa, M., Ito, H., Akiyoshi, M., Kume, N., Yoshitomi, H., Mitsuoka, H., Tanida, S., Murata, K., Shibuya, H., Kasahara, T., Kakino, A., Fujita, Y., Sawamura, T., Yasuda, T. and Nakamura, T.


Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox.
Proc Jpn Acad Ser B Phys Biol Sci,87:104-113 2011
Author:Nishizuka, T., Fujita, Y., Sato, Y., Nakano, A., Kakino, A., Ohshima, S., Kanda, T., Yoshimoto, R. and Sawamura, T.


An alternative protein standard to measure activity of LOX-1 ligand containing apoB (LAB) - utilization of anti-LOX-1 single- chain antibody fused to apoB fragment.
J Atheroscler Thromb,18:818-828 2011
Author:Iwamoto, S., Fujita, Y., Kakino, A., Yanagida, K., Matsuda, H., Yoshimoto, R. and Sawamura, T.


Lectin-like oxidized LDL receptor 1 is involved in CRP-mediated complement activation.
Clin Chem,57:1398-1405 2011
Author:Fujita, Y., Yamaguchi, S., Kakino, A., Iwamoto, S., Yoshimoto, R. and Sawamura, T.


C-reactive protein uptake by macrophage cell line via class-A scavenger receptor.
Clin Chem,56:478-481 2010
Author:Fujita, Y., Kakino, A., Harada-Shiba, M., Sato, Y., Otsui, K., Yoshimoto, R. and Sawamura, T.


LOX index, a novel predictive biochemical marker for coronary heart disease and stroke.
Clin Chem,56:550-558 2010
Author:Inoue, N., Okamura, T., Kokubo, Y., Fujita, Y., Sato, Y., Nakanishi, M., Yanagida, K., Kakino, A., Iwamoto, S., Watanabe, M., Ogura, S., Otsui, K., Matsuda, H., Uchida, K., Yoshimoto, R. and Sawamura, T.


LOX-1 mediates vascular lipid retention under hypertensive state.
J Hypertens,28:1273-1280 2010
Author:Nakano, A., Inoue, N., Sato, Y., Nishimichi, N., Takikawa, K., Fujita, Y., Kakino, A., Otsui, K., Yamaguchi, S., Matsuda, H. and Sawamura, T.


Pitavastatin reduces lectin-like oxidized low-density lipoprotein receptor-1 ligands in hypercholesterolemic humans.
Lipids,45:329-335 2010
Author:Matsumoto, T., Fujita, M., Sawamura, T., Kakino, A., Sato, Y., Fujita, Y., Matsuda, H., Nakanishi, M., Uchida, K., Nakae, I., Kanda, H., Yoshida, A., Miwa, K., Hayashi, H., Mitsunami, K. and Horie, M.


Oxidized LDL receptor LOX-1 binds to C-reactive protein and mediates its vascular effects.
Clin Chem,55:285-294 2009
Author:13. Fujita, Y., Kakino, A., Nishimichi, N., Yamaguchi, S., Sato, Y., Machida, S., Cominacini, L., Delneste, Y., Matsuda, H. and Sawamura, T.


LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells.
Cardiovasc Res,84:127-136 2009
Author:Sugimoto, K., Ishibashi, T., Sawamura, T., Inoue, N., Kamioka, M., Uekita, H., Ohkawara, H., Sakamoto, T., Sakamoto, N., Okamoto, Y., Takuwa, Y., Kakino, A., Fujita, Y., Tanaka, T., Teramoto, T., Maruyama, Y. and Takeishi, Y.


DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics.
Mol Cell Biol,27:7028-7040 2007
Author:Ikura, T., Tashiro, S., Kakino, A., Shima, H., Jacob, N., Amunugama, R., Yoder, K., Izumi, S., Kuraoka, I., Tanaka, K., Kimura, H., Ikura, M., Nishikubo, S., Ito, T., Muto, A., Miyagawa, K., Takeda, S., Fishel, R., Igarashi, K. and Kamiya, K.