
Nakamura Kozo
Academic Assembly School of Science and Technology Institute of Agriculture
Faculty of Agriculture Department of Agricultural and Life Sciences Division of Bioscience and Biotechnology
Associate Professor
Researcher Information
Research Keyword
- Food Functionality, Food Chemistry, Food Molecules, Blood pressure, Eggplant, Acetylcholine, personal nutrition optimized diet, personalized nutrition, personal nutrition optimized diet
Field Of Study
TEL
- +81-265-77-1638
Research activity information
Paper
- Polyunsaturated fatty acid deficiency affects sulfatides and other sulfated glycans in lysosomes through autophagy-mediated degradation
 Yaping Wang, Takero Nakajima, Pan Diao, Yosuke Yamada, Kozo Nakamura, Jun Nakayama, Naoki Tanaka, Toshifumi Aoyama, Yuji Kamijo *
 FASEB Journal, 34(7), 9594-9614, 30 Jun. 2020, Refereed 
- Daily Ingestion of Eggplant Powder Improves Blood Pressure and Psychological State in Stressed Individuals: A Randomized Placebo-Controlled Study
 Mie Nishimura, Miho Suzuki, Ryuto Takahashi, Shohei Yamaguchi, Kazufumi Tsubaki, Tomoyuki Fujita, Jun Nishihira *, Kozo Nakamura *
 Nutrients, 11, 2797, 16 Nov. 2019, Refereed 
- Antihypertensive effects of orally administered eggplant (Solanum melongena) rich in acetylcholine on spontaneously hypertensive rats
 Shohei Yamaguchi, Kento Matsumoto, Masahiro Koyama, Su Tian, Masanori Watanabe, Akihiko Takahashi, Koji Miyatake and Kozo Nakamura*
 Food Chem., 276, 376-382, 15 Mar. 2019, Refereed 
- Evaluating of quality of rice bran protein concentrate prepared by a combination of isoelectronic precipitation and electrolyzed water treatment
 Masanori Watanabe*, Chikako Yamada, Isamu Maeda, Charin Techapun, Ampin Kuntiya, Noppol Leksawasdi, Phisit Seesuriyachan, Thanongsak Chaiyaso, Shinji Takenaka, Tadahiko Shiono, Kozo Nakamura, Shujiro Endo
 LWT-Food Sci. Technol., 99, 262-267, 05 Oct. 2018, Refereed 
- Geniposidic acid upregulates atrial natriuretic peptide secretion and lowers blood pressure in spontaneously hypertensive rats
 Kozo Nakamura*, Shingo Hosoo, Shohei Yamaguchi, Masahiro Koyama, Ryo Yamazaki, Tetsuya Hirata, Yasuyo Yamaguchi, Hiroo Yamasaki, Naoto Minamino, Keiji Wada, Sansei Nishibe
 J. Funct. Food., 40, 634-638, Jan. 2018, Refereed 
- Preventive Effect of Eucommia Leaf Extract on Aortic Media Hypertrophy in Wistar Kyoto Rats Fed a High-fat Diet
 Shingo Hosoo, Masahiro Koyama, Akira Watanabe, Ryuya Ishida, Tetsuya Hirata, Yasuyo Yamaguchi, Hiroo Yamasaki, Keiji Wada, Yukihito Higashi and Kozo Nakamura*
 Hypertension Research, 40(6), 546-551, Jul. 2017, Refereed 
- Decreased Fatty Acid β-Oxidation Is the Main Cause of Fatty Liver Induced by Polyunsaturated Fatty Acid Deficiency in Mice
 Takero Nakajima, Yang Yang, Yu Lu, Yuji Kamijo, Yosuke Yamada, Kozo Nakamura, Masahiro Koyama, Shohei Yamaguchi, Eiko Sugiyama, Naoki Tanaka, Toshifumi
 Tohoku J. Exp. Med., 242, 229-239, Jul. 2017, Refereed 
- Fermentation-induced changes in the concentrations of organic acids, amino acids, sugars, and minerals and superoxide dismutase-like activity in tomato vinegar
 Masahiro Koyama, Yasushi Ogasawara, Kiyoshi Endou, Hirofumi Akano, Takero Nakajima, Toshifumi Aoyama, Kozo Nakamura*
 Int. J. Food Prop., 20(4), 888–898, Mar. 2017, Refereed 
- Extracellular protease derived from lactic acid bacteria stimulates the fermentative lactic acid production from the by-products of rice as a biomass refinery function
 Masanori Watanabe*, Charin Techapun, Ampin Kuntiya, Noppol Leksawasdi, Phisit Seesuriyachan, Thanongsak Chaiyaso, Shinji Takenaka, Isamu Maeda, Masahiro Koyama, Kozo Nakamura
 J. Biosci. Bioeng., 123(2), 245-251, Jan. 2017, Refereed 
- The Restorative Effects of Eucommia ulmoides Oliver Leaf Extract on Vascular Function in Spontaneously Hypertensive Rats
 Shingo Hosoo, Masahiro Koyama, Mai Kato, Tetsuya Hirata*, Yasuyo Yamaguchi, Hiroo Yamasaki, Atsunori Wada, Keiji Wada, Sansei Nishibe and Kozo Nakamura*
 MOLECULES, 20, 21971-81, 09 Dec. 2015, Refereed 
- Characterization of bioactive agents in five types of marketed sprouts and comparison of their antihypertensive, antihyperlipidemic, and antidiabetic effects in fructose-loaded SHRs
 Kozo Nakamura*, Masahiro Koyama, Ryuya Ishida, Takashi Kitahara, Takero Nakajima, Toshifumi Aoyama
 J. Food Sci. Tech., published online (DOI 10.1007/s13197-015-2048-0), 01 Oct. 2015, Refereed 
- Simultaneous recovery and purification of rice protein and phosphorus compounds from full-fat and defatted rice bran with organic solvent-free process
 Masanori Watanabe, Isamu Maeda, Kozo Nakamura, Masahiro Koyama, Kazuo Sasano
 J. Biosci. Bioeng., 119(2), 206-2011, Feb. 2015, Refereed
- Identification of Trypsin Inhibitors from Potato Extract
 Keisuke Yataka, Hiroshi Tomozawa, Masahito Tsubata, Kazuya Yamaguchi, and Kozo Nakamura*
 th Asia-Pacific International Peptide Symposium/50th Japanese Peptide Symposium/Peptide Science 2013, 393-396, Mar. 2014, Refereed
- An Ex Vivo Assay to Measure ACE Inhibitory Activities using Thoracic Aorta Ring
 Masahiro Koyama, Ryuya Ishida, Seiji Hattori, and Kozo Nakamura*
 th Asia-Pacific International Peptide Symposium/50th Japanese Peptide Symposium/Peptide Science 2013, 397-400, Mar. 2014, Refereed
- Vasoactivities in Normotensive and Hypertensive Rats of Neo-Fermented Buckwheat Sprout and an Antihypertensive Peptides Therein
 Masahiro Koyama, Seiji Hattori, Mai Kato, Kyoko Naramoto, and Kozo Nakamura*
 th Asia-Pacific International Peptide Symposium/50th Japanese Peptide Symposium/Peptide Science 2013, 401-404, Mar. 2014, Refereed
- Fermentative L-(+)-lactic acid production from non-sterilized rice washing drainage containing rice bran by a newly isolated lactic acid bacteria without any additions of nutrients
 Masanori Watanabe*, Masahiro Makino, Nobuo Kaku, Masahiro Koyama, Kozo Nakamura, and Kazuo Sasano
 J. Biosci. Bioeng., 115(4), 449-52, Nov. 2012, Refereed  
- Peroxisome proliferator-activated receptor α mediates enhancement of gene expression of cerebroside sulfotransferase in several murine organs
 Takero Nakajima1, Yuji Kamijo, Huang Yuzhe, Takefumi Kimura, Naoki Tanaka, Eiko Sugiyama, Kozo Nakamura, Mamoru Kyogashima, Atsushi Hara, Toshifumi Aoyama
 Glycoconjugate J., 30(6), 553-60, Oct. 2012, Refereed   
- Interaction of epicatechin gallate with phospholipid membranes as revealed by solid-state NMR spectroscopy
 Yoshinori Uekusa, Miya Kamihira-Ishijima, Osamu Sugimoto, Takeshi Ishii, Shigenori Kumazawa, Kozo Nakamura, Ken-ichi Tanji, Akira Naito, and Tsutomu Nakayama*
 Biochim. Biophys. Acta, 1808(6), 1654-1660, Jun. 2011, Refereed  
- Peptides in an Antihypertensive Food Made from Buckwheat
 Masahiro Koyama, Kyoko Naramoto, and Kozo Nakamura
 Proceeding Book for 5th International Peptide Symposium/Peptide Science 2010, 280, Apr. 2011, Refereed
- 有機酸類がフェノール化合物の渋味・苦味におよぼす影響
 小山正浩,小嶋裕士,藤森清司,中村浩蔵*
 日本味と匂学会誌, 17(3), 351-354, Dec. 2010, Refereed
- Correlation of Polyphenolics Content to Antioxidant Activity of Forsythia Suspensa Leaves
 Su Tian, Yan Wang, and Kozo Nakamura
 Program&Proceedings of Shinshu University International Symposium 2010, 79-84, Feb. 2010
- Differences of Sesquiterpene Lactones Content in Different Leaf Parts and Head Formation Stages in Lettuce
 Kojiro Arakawa, Mineo Minami*, Kozo Nakamura, Ken-ichi Matsushima and Kazuhiro Nemoto
 Hort. Res., 8(1), 13-17, Aug. 2009, Refereed
- Loss of Sweetness of Monatin with Lactamization
 Reito Ikeda, Kana Kogiso, Yasunori Maejima, and Kozo Nakamura
 Proceedings of 7th Australian Peptide Conferences/ 4th International Peptide Symposium/ 2nd Asia-Pacific Peptide Symposium, 1-4, Sep. 2008
- Variation of Sesquiterpene Lactones Content in Lactuca and Cichorium Species
 Kojiro Arakawa, Mineo Minami*, Kozo Nakamura, Ken-ichi Matsushima and Kazuhiro Nemoto
 Hort. Res., 7(4), 499–504, Aug. 2008, Refereed
- Cholesterol-lowering effect of bezafibrate is independent of peroxisome proliferator-activated receptor activation in mice.
 Tekero Nakajima, Tanaka N, Sugiyama E, Kamijo Y, Hara A, Hu R, Li G, Li Y, Kozo Nakamura, Gonzalez FJ and Toshifumi Aoyama*
 Biochem Pharmacol, 76, 108-119, Apr. 2008, Refereed
- モナティン類縁体の甘味発現に関与する官能基の探索とその反応性
 池田玲敏,小木曽加奈,中村浩蔵*
 日本味と匂学会誌, 14(3), 419-422, Dec. 2007, Refereed
- Development of Taste Evaluation System of Monatin Related Compounds Using Computer Modeling Method
 Kozo Nakamura, Kana Kogiso, Reito Ikeda, and Kazumasa Furuta
 Proceeding of the International Conference of 43rd Japanese Peptide Symposium and 4th Peptide Engineering Meeting/Peptide Science 2006, 133-134, Nov. 2007, Refereed
- γ-アミノ酸導入ペプチドの呈味発現
 中村浩蔵*,古田一匡,池田玲敏,小山卓郎,小木曽加奈
 日本味と匂学会誌, 13(3), 431-434, Dec. 2006, Refereed
- 甘味を持つ異常アミノ酸Monatinとそのアナログの呈味発現
 小木曽加奈, 中村浩蔵*, 古田一匡, 茅原 紘
 日本味と匂学会誌, 12(3), 565-568, Dec. 2005, Refereed
- The C-C bond formation with Alkyl Halide in Monatin Analogue Synthesis and Their Tastes Expression
 Kana Kogiso, Kozo Nakamura, and Hiroshi Kayahara
 The Proceedings of the Joint Meeting of 1st Asia-Pacific International Peptide Symposium&40st Japanese Peptide Symposium, Peptide Science 2004, 553-556, Apr. 2005, Refereed
- Sweetness Production of Taurine Di-peptides Based on Their Crystal Structures and Characterized Conformations
 Kozo Nakamura, Takuro Koyama, Takero Nakajima, Kana Kogiso, and Hiroshi Kayahara
 The Proceedings of the Joint Meeting of 1st Asia-Pacific International Peptide Symposium&40st Japanese Peptide Symposium, Peptide Science 2004, 165-168, Apr. 2005, Refereed
- Synthesis of Amide Compounds of Ferulic Acid, and Their Stimulatory Effect on Insulin Secretion In Vitro
 Eisuke Nomura, Ayumi Kashiwada, Asao Hosoda, Kozo Nakamura, Hideko Morishita, Takuo Tsuno and Hisaji Taniguchi*
 Bioorg. Med. Chem., 11, 3807-3813, Mar. 2003, Refereed
- Total Synthesis of Monatin
 Kozo Nakamura, Tracy J. Baker, and Murray Goodman*
 Org. Lett., 2(19), 2967-2970, Aug. 2000, Refereed
- Further studies on the preparation of low sodium chloride-containing soy sauce by using ornithyltaurine hydrochloride and its related compounds
 Rie Kuramitu, Daisuke Segawa, Kozo Nakamura, Syunsuke Muramatsu and Hideo Okai*
 Biosci. Biotech. Biochem., 61(7), 1163-1167, Jul. 1997, Refereed
- 合成ペプチドおよび類縁体を用いた呈味-構造相関性に関する研究並びに新呈味剤開発の試み
 中村浩蔵
 広島大学大学院工学研究科学位論文, Nov. 1996, Refereed
- Tastes Produced by Peptides Containing Ionic Groups and by Related Compounds
 Rie Kuramitu, Masatoshi Takahashi, Kouji Tahara, Daisuke Segawa, Kozo Nakamura, and Hideo Okai*
 Biosci. Biotech. Biochem., 60(10), 1637-1642, Oct. 1996, Refereed
- A Convenient Synthesis of L-Ornithyltaurine・HCl and the Effect on Saltiness in a Food Material
 Kozo Nakamura, Rie Kuramitu, Shiro Kataoka, Daisuke Segawa, Kouji Tahara, Masahiro Tamura, and Hideo Okai*
 J. Agric. Food. Chem., 44(9), 2481-2485, Sep. 1996, Refereed
- Preparation of Low Sodium Chloride Containing Soy Sauce Using Amino Acid Based Saltiness Enhancers
 Daisuke Segawa, Kozo Nakamura, Rie Kuramitu, Syunsuke Muramatu, Yoshio Sano, Yasuyuki Uzuka, Masahiro Tamura, and Hideo Okai*
 Biosci. Biotech. Biochem., 59(1), 35-39, Jan. 1995, Refereed
- Relationship between Taste and Structure of O-Aminoacyl Sugars Containing Basic Amino Acid.
 Masahiro Tamura, Kozo Nakamura, Keisuke Kinomura and Hideo Okai*
 Biosci. Biotech. Biochem., 57(1), 20-23, Jan. 1993, Refereed
Books and other publications
- Peptide Science 2018
 Ryuto Takahashi, Nao Sugiman, Shingo Hosoo, Tetsuya Hirata, Yasuyo Yamaguchi, Hiroo Yamasaki, Shohei Yamaguchi, Naoto Minamino, Kozo Nakamura*, Geniposidic Acid Induces Natriuretic Effect by Upregulate Atrial Natriuretic Peptide in Spontaneously Hypertensive Rats
 29 Mar. 2019Peptide Science 2018
 Shohei Yamaguchi, Shingo Hosoo, Yusuke Takahashi, Ryo Yamazaki, Ryuto Takahashi, Tetsuya Hirata, Yasuyo Yamaguchi, Hiroo Yamasaki, Naoto Minamino and Kozo Nakamura*, Geniposidic Acid Can Induce Secretion of Atrial Natriuretic Peptide via Glucagon-like Peptide-1 Receptor on Spontaneously Hypertensive Rats
 30 Mar. 2019Peptide Science 2017
 Shohei Yamaguchi, Shingo Hosoo, Masahiro Koyama, Ryo Yamazaki, Tetsuya Hirata, Yasuyo Yamaguchi, Hiroo Yamasaki, Naoto Minamino, Keiji Wada, Sansei Nishibe, Kozo Nakamura*, Joint work, Oral Administlation of Geniposidic Acid Induces Secretion of Atrial Natriuletic Peptide in Spontaneously Hypertensive Rats
 174-175 Feb. 2018
 ISBN:978-4-931541-184機能性食品開発のための初期評価試験プロトコール集(監修: 山本(前田)万里)
 山本(前田)万里他57名, 【第Ⅱ編 機能性評価】第2章 血圧降下作用、1 in vitro ACE 阻害活性試験、2 ex vivo ACE 阻害活性試験、3 in vivo ACE 阻害活性試験、4 ラット血圧測定試験
 シーエムシー出版, 53-75 Jun. 2017
 ISBN:978-4-7813-1248-4Peptide Science 2016
 Masahiro Koyama, Shihori Iwamoto, Sho Okitsu, Kozo Nakamura*, Joint work, Angiotensin I Converting Enzyme Inhibitory Effect of Antihypertensive Peptides Mixture
 25-26 Feb. 2017, Refereed
 ISBN:978-4-931541-177Peptide Science 2015
 Masahiro Koyama, Sho Okitsu, Daisuke Hayasaki, Kozo Nakamura*, Joint work, ACE Inhibitory Peptide Accumulated and Produced ACE Inhibitory Fragments in Rat Aorta Tissue to Suppress Vasoconstriction
 49-52 Mar. 2016, Refereed
 ISBN:978-4-931541-16-0Peptide Science 2014
 Masahiro Koyama1, Sho Okitsu, Akira Watanabe and Kozo Nakamura*, Joint work, Difference between In Vitro, Ex Vivo, and In Vivo Angiotensin I Converting Enzyme Inhibition by Antihypertensive Peptides from Fermented Buckwheat Sprout
 43-46 Mar. 2015, Refereed
 ISBN:978-4-931541-15-3Peptide Science 2012
 Masahiro Koyama, Seiji Hattori, Mai Kato, Kyoko Naramoto, and Kozo Nakamura*, Joint work, Antihypertensive Peptides Isolated from Fermented Buckwheat Sprout
 27-30 Mar. 2013, RefereedPeptide Science 2011
 Masahiro Koyama, Yukimi Hashiguchi and Kozo Nakamura*, Joint work, Antihypertensive Actions of the Gly-His-Gly Isolated from Fermented Buckwheat Sprout
 115-118 2012, RefereedPeptide Science 2007
 Kozo Nakamura, Kyoko Naramoto, and Mari Fujita, Joint work, Blood-pressure-lowering Effect of Fermented Buckwheat Sprout and the Peptides Contained Therein
 13-16 Jan. 2008, RefereedPeptide Science 2005
 KozoNakamura, Yasunori Maejima, Shigeyoshi Maejima, and Emi Niimura, Joint work, Isolation of Hydrophilic ACE Inhibitory Peptides from Fermented Buckwheat Sprout
 155-158 Mar. 2006, RefereedPeptide Science 2005
 Kana Kogiso, Kazumasa Furuta, Hiroshi Kayahara, and Kozo Nakamura*, Joint work, Using Computer Modeling to Study Lactam Ring Formation during Monatin and the Analogue Synthesis
 191-194 Mar. 2006, RefereedFood Flavor and Chemistry, Explorations into the 21st Century
 Kozo Nakamura,Chiho Nakamura,Shigeyoshi Maejima,Masataka Maejima,Michiaki Watanabe, Mayumi Shiro,and Hiroshi Kayahara, Joint work, The Functionality of Backwheat Sour Juice
 The Royal Society of Chemistry, 350-355 Jun. 2005Food Flavor and Chemistry, Explorations into the 21st Century
 Kozo Nakamura,Su Tian, and Hiroshi Kayahara, Joint work, Functionality Enhancement in Germinated Brown Rice
 The Royal Society of Chemistry, 356-371 Jun. 2005特許,発芽そばへの道 4
 大西利光, 茅原 紘, 中村浩蔵, Joint work, 第4章 発芽そばの成分分析
 (有)川辺書林, 125-155 Jan. 2005Peptide Science 2003
 Kozo Nakamura, Kana Kogiso, Takero Nakajima and Hiroshi Kayahara, Joint work, Total Synthesis of Monatin and the Taste Expression.
 61-64 Jan. 2004, RefereedPeptide Science 2003
 Kana Kogiso, Kozo Nakamura and Hiroshi Kayahara, Joint work, Control of Lactamization in the Synthesis of Monatin Analogue.
 195-198 Jan. 2004, RefereedPeptide Science 2003
 Takuro Koyama, Hiroshi Kayahara and Kozo Nakamura, Joint work, Synthesis of Taurine Peptides and Taste.
 199-202 Jan. 2004, Refereedみすずかる信濃の健康志向食品
 中村浩蔵, 茅原 紘, Joint work, ミツバチの贈り物
 郷土出版社, 169-186 Sep. 2003Peptide Science 2002
 Kozo Nakamura, Eri Kato, Kana Ando and Hiroshi Kayahara, Joint work, Taste and ACE Inhibitory Activity of g-Aminobutyric Acid Containing Peptides
 179-182 Mar. 2003, RefereedPeptide Science 2001
 Kozo Nakamura, Eisaku Nomura and Hisaji Taniguchi, Joint work, Chemical properties of acyl groups on phenolic hydroxy group of tyrosine.
 43-46 Mar. 2002, RefereedChemistry of Novel Foods,
 Rie Kuramitu, Kozo Nakamura, and Hideo Oka, Joint work, Role of "Ionic Tastes” in Food Materials
 Allured Pub. Corp, 19-31 Jan. 1997Chemistry of Novel Foods
 Jirou Okai, Takashi Nakata, Kozo Nakamura, Masahiro Tamura, and Hideo Okai, Joint work, Convenient Synthesis of Flavor Peptides Using DSP, HOBMCl, and Their Derivatives
 Allured Pub. Corp., 33-43 Jan. 1997Chemistry of Novel Foods
 Kozo Nakamura, Takao Fukuma, Toshinori Shimizu, and Hideo Okai, Joint work, What is the Meaning of the Structural Similarities between Sweet and Bitter Compounds?
 Allured Pub. Corp., 66-79 Jan. 1997食品工業における科学・技術の進歩(VII)
 岡井秀雄, 中村浩蔵, 倉光利江, Joint work, ペプチド性塩から味代替物質
 光琳, 49-66 Jan. 1997Peptide Chemistry 1994
 Masatoshi Takahashi, Takashi Nakata, Masaru Nakatani, Shirou Kataoka, Kozo Nakamura, and Hideo Okai, Joint work, Conversion of Bitterness of C-Terminal Octapeptide of Bovine b-Casein (Arg-Gly-Pro-Phe-Pro-Ile-Ile-Val) into Sweetness
 281-284 Mar. 1995, RefereedPeptide Chemistry 1994
 Masatoshi Takahashii, Kozo Nakamura and Hideo Okai, Joint work, Can We Obtained Strong Sweetness According to Sweet Peptide Model?
 57-60 Mar. 1995, RefereedPeptide Chemistry 1993
 Kozo Nakamura and Hideo Okai, Joint work, Molecular Recognition of Sweet Compounds and Bitter Compounds
 329-332 Mar. 1994, RefereedPeptide Chemistry 1992
 Kozo Nakamura, Daisuke Segawa, Keisuke Kinomura, Masahiro Tamura and Hideo Okai, Joint work, Synthesis of Saccharoide (Complex Containing Saccharide and Peptide)
 427-430 Jul. 1993, RefereedFood Flavor and Safety, Molecular Analysis and Design
 Kozo Nakamura, and Hideo Okai*, Joint work, Do We Recognize Sweetness and Bitterness at the Same Receptor?
 American Chemical Society, 28-35 Feb. 1993Affiliated academic societyResearch Themes- Study on Food Functions of Choline Esters, New Functional Food Factors
- Study on Food Functions and Mechanisms of Choline Esters
- Study on Food Functions of Eggplant Rich in Choline Esters
- Study on Food Functions of Eucommia ulmoides Oliver Leaf
- Personalized Healthcare Using Foods with Optimized Nutrition