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OYANAGI Kiyomitsu

Academic OrganizationTEL
Education and Research OrganizationSchool of Medicine Department of Brain Disease ResearchFAX
PositionProfessorMail Addressk123ysm@shinshu-u.ac.jp
Address8-27-3-705 Toshima, Kita-ku, Tokyo 114-0003Web site

Profile

Research Field
Neuroanatomy/Neuropathology
Keywords:Nervous system , Pathology
Current Subject
ALS
Keywords:motoneuron
Parkinson's disease
Keywords:substantia nigra , dopamine
Lesion repair
Keywords:neuron , spinal cord
Dementia
Keywords:tau
Academic Societies
Academic Societies
The Japanese Society of Neuropathology
American Association of Neuropathologists
Japanese Society of Neurology

Committee of Academic Societies
The Japanese Society of Neuropathology , Honorary member
Awards
2016 , Dean of Shinshu University School of Medicine Award
2002 , Weil Award
2002 , Tokyo Metropolitan Governor Award

Research

Books, Articles, etc.
Books
Parkinsonism-Dementia Complex of Guam, Neurodegeneration the molecular pathology of dementia and movement disorders , 171-178
Wiley-Blackwell 2011
Author:Kiyomitsu Oyanagi, Tomoyo Hashimoto, Mineo Yamazaki


Magnesium in Parkinson's disease: an update in clinical and basic aspects, Magnesium in the Central Nervous System , 229-236
University of Adelaide Press 2011
Author:Oyanagi K, Hashimoto T


Articles
Dysfunction of protein quality control in parkinsonism-dementia compex of Guam
Froniiers of Neurology,9:173 2018(Mar.)
Author:Verheijen BM, Oyanagi K, van Leeuwen FW


Atypical lower motor neuron disease with enlargement of Nissl substance: report of an autopsy case
Clinical Neuropathology,37(2):74-81 2018(Feb.)
Author:Shintaku M, Kaneda D, Oyanagi K


Deposition of mutant ubiquitin in parkinsonism-dementia complex of Guam
Acta Neuropathologica Communications,5:82 2017
Author:Verheijen BM, Hashimoto T, Oyanagi K, van Leeuwen FW


Novel intracytoplasmic inclusions immunopositive for phosphorylated-TDP43 and cystatin C in anterior horn cells in a case of sporadic amyotrophic lateral sclerosis
Neuropathology,37:526-534 2017
Author:Shintaku M, Kaneda D, Oyanagi K


An autopsy case of respiratory failure induced by repetitive cervical spinal cord damage due to abnormal movement of the neck in athetoid palsy
Internal Medicine,56:1425-1430 2017
Author:Takei Y, Koshihara H, Oguchi K, Oyanagi K, Ohara S


Adult onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) and Nasu-Hakola disease: Lesion staging and dynamic changes of axons and microglial subsets.
Brain Pathol,27:748-769 2017
Author:Oyanagi K, Kinoshita M, Suzuki-Kouyana E, Inoue T, Nakahara A, Tokiwai M, Arai N, Satoh JI, Aoki N, Jinnai K, Yazawa I, Arai K, Ishihara K, Kawamura M, Ishizawa K, Hasegawa K, Yagisita S, Amano N, Yoshida K, Terada S, Yoshida M, Akiyama H, Mitsiyama Y, Ikeda S.


Shinshu Brain Resource Net.
Neuropathology,36(6):600-601 2016(Dec.)
Author:Oyanagi K, Yamada M, Hineno A, Yahikozawa H, Ushiyama M, Miki J, Kanno H, Nakayama J, Makishita H, Inoue K, Ohara S, Hayashida K, Kayanuma K, Yamamoto K, Yasude T, Hashimoto T, Yoshida K, Ikeda SI.


Axonal TDP-43 aggregates in sporadic amyotrophic lateral sclerosis.
Neuropathol Appl Neurobiol,42(6):561-72 2016(Oct.)
Author:Onozato T, Nakahara A, Suzuki-Kouyama E, Hineno A, Yasude T, Nakamura T, Yahikozawa H, Watanabe M, Kayanuma K, Makishita H, Ohara S, Hashimoto T, Higuchi K, Sakai T, Asano K, Hashimoto T, Kanno H, Nakayama J, Oyanagi K.


Clinicopathological characteristics of patients with amyotrophic lateral sclerosis resulting in a totally locked-in state (communication Stage V).
Acta Neuropathol Commun,4(1):107 2016(Sep.)
Author:Hayashi K, Mochizuki Y, Takeuchi R, Shimizu T, Nagao M, Watabe K, Arai N, Oyanagi K, Onodera O, Hayashi M, Takahashi H, Kakita A, Isozaki E.


Hippocampal sclerosis in the parkinsonism-dementia complex of Guam: quantitative examination of neurons, neurofibrillary tangles, and TDP-43 immunoreactivity in CA1.
Neuropathology,35(3):224-35 2015(Jan.)
Author:Oyanagi K, Yamazaki M, Hashimoto T, Asakawa M, Wakabayashi K, Takahashi H.


Predictors of impaired communication in amyotrophic lateral sclerosis patients with tracheostomy-invasive ventilation.
Amyotroph Lateral Scler Frontotemporal Degener,17(1-2):38-46 2015
Author:Nakayama Y, Shimizu T, Mochizuki Y, Hayashi K, Matsuda C, Nagao M, Watabe K, Kawata A, Oyanagi K, Isozaki E, Nakano I.


Development of primary central nervous lymphoma associated with human immunodeficiency virus and JC virus infection.
J Clin Exp Hematopathol 2014
Author:Kawakami T, Sakai K, Mimura Y, Senoo Y, et al.


Zinc Transporters (ZnT3 and 6) Are Downregulated in the Spinal Cords of Patients with Sporadic Amyotrophic Lateral Sclerosis.
J Neurosci Res,93(2):370-379 2014
Author:Kaneko M, Noguchi T, Ikegami S, Oyanagi K, Inuzuka T, Takahashi H, Hozumi I.


Hippocampal sclerosis in the parkinsonism-dementia complex of Guam: quantitative examination of neurons, neurofibrillary tangles, and TDP-43 immunoreactivity in CA1.
Neuropathology 2014
Author:Oyanagi K, Yamazaki M, Hashimoto T, Asakawa M, Wakabayashi K, Takahashi H.


Mannitol infusion immediately after reperfusion suppresses the development of focal cortical infarction after temporary cerebral ischemia in gerbils.
Neuropathology,34(4):360-369 2014
Author:Ito U, Hakamata Y, Watabe K, Oyanagi K


Distinctive features of degenerating Purkinje cells in spinocerebellar ataxia type 31.
Neuropathology,34:261-267 2014
Author:Yoshida K, Asakawa M, Suzuki-Kouyama E, Tabata K, Shintaku M, Ikeda S, Oyanagi K


Comparative study of fibrin and chemical synthetic sealant on dural regeneration and brain damage.
Neurosurg 2014
Author:Ito K, Horiuchi T, Oyanagi K, Nomiyama T, Hongo K


An autopsy case of familial amyotrophic lateral sclerosis with FUS R521G mutation.
Amyotroph Lateral Scler Frontotemporal Degener,15:305-308 2014
Author:Mochizuki Y, Kawata A, Hashimoto T, Akiyama H, Kawakami H, Komori T, Oyanagi K, Mizutani T, Matsubara S


“Gliomatosis encephali” as s novel category of brain tumor by the first autopsy case report of gliomatosis cerebelli.
Neuropathology,34:295-303 2014
Author:Nakahara A, Yoshida T, Yazawa M, Ehara T, Nakayama J, Kakita A, Ogura R, Asakawa M, Suzuki-Kouyama E, Oyanagi K


Pathological features of FTLD-FUS in a Japanese population: analyses of nine cases
J Neurol Sci,335:89-95 2013
Author:Kobayashi Z, Kawakami I, Arai T, Yokota O, Tsuchiya K, Kondo H, Shimomura Y, Haga C, Aoki N, Hasegawa M, Hosokawa M, Oshima K, Niizato K, Ishizu H, Terada S, Onaya M, Ikeda M, Oyanagi K, Nakano I, Murayama S, Akiyama H, Mizusawa H


Distinctive clinicopathological features of 2 large families with amyotrophic lateral sclerosis having L106V mutation in SOD1 gene
J Neurol Sci,319:63-74 2012
Author:Hineno A, Nakamura A, Shimojima Y, Yoshida K, Oyanagi K, Ikeda S


Familial ALS with FUS P525L mutation: two Japanese sisters with multiple system involvement
J Neurol Sci,323:85-92 2012
Author:Mochizuki Y, Isozaki E, Takao M, Hashimoto T, Shibuya M, Arai M, Hosokawa M, Kawata A, Oyanagi K, Mihara B, Mizutani T


Hereditary diffuse leukoencephalopathy with axonal spheroids caused by R782H mutation in CSF1R: Case report
J Neurol Sci,318:115-118 2012
Author:Kinoshita, M., Yoshida, K., Oyanagi, K., Hashimoto, T., Ikeda, S


Temporary focal cerebral ischemia results in swollenn astrocytic end-feet that compress microvessels and lead to focal cortical infarction
Journal of Cerebral Blood Flow and Metabolism,31:328-338 2011
Author:Ito U, Hakamata Y, Kawakami E, Oyanagi K


Radiologic and neuropathologic findings in patients in afamily with dentatorubral-pallidoluysian atrophy
Ameerican Journal of Neuroradiology,32:109-114 2011
Author:Sunami Y, Koide R, Arai N, Yamada M, Mizutani T, Oyanagi K


Survival motor neuron (SMN) protein in the spinal anterior horn cells of patients with sporadic amyotrophic lateral sclerosis
Brain Research,1372:152-159 2011
Author:Piao Y, Hashimoto T, Takahama S, Kakita A, Komori T, Morita T, Takahashi H, Mizutani T, Oyanagi K


Distinctive expression of midkine in the repair period of rat brain during neurogenesis : Immunohistochemical and immunoelectron microscopic observations
J.Neurosci Res,75(5):678-687 2004
Author:Kikuchi-Horie, K; Kawakami, E; Kamata, M; Wada, M; Hu, JG; Nakagawa, H; Ohara, K; Watabe, K; Oyanagi, K


Temporal profile of experimental ischemic edema after threshold amount of insult to induce infarction-ultrastructure, gravimetry and Evans' blue extravasation
Acta Neurochir,86(Suppl):131-135 2003
Author:Ito U, Kuroiwa T, Hanyu S, Hatanaka Y, Kawakami E, Nakano I, Oyanagi K


Pathological involvement of the motor neuron system and hippocampal formation in motor neuron disease -inclusion dementia
Acta Neuropathologica ,106(1):50-56 2003
Author:Toyoshima, Y; Piao, YS; Tan, CF; Morita, M; Tanaka, M; Oyanagi, K; Okamoto, K; Takahashi, H


Histone deacetylase activity is retained in primary neurons expressing mutant huntingtin protein
J Neurochemistry ,87(1):257-267 2003
Author:Hoshino, M; Tagawa, K; Okuda, T; Murata, M; Oyanagi, K; Arai, N; Mizutani, T; Kanazawa, I; Wanker, EE; Okazawa, H


Widespread vertebral and venous plexus metastasis of prostatic carcinoma presenting wedge-shaped radial lesions in the spinal cord
Neuropathology,23(4):296-300 2003
Author:Oyanagi, K; Ogata, K; Takeda, S; Horikawa, Y; Kawakami, E; Morita, T


Topical instillation of ciliary neurotrophic factor inhibits retinal degeneration in streptozotocin -induced diabetrc rats
Neuro Report ,14(16):2067-2071 2003
Author:Aizu, Y; Katayama, H; Takahama, S; Hu, JG; Nakagawa, H; Oyanagi, K


Neuropathology with clinical correlations of sporadic amyotrophic lateval sclerosis: 102 autopsy cases examined between 1962 and 2000
Brain Pathology ,12:10-22 2003
Author:Piao, YS; Wakabayashi, K; Kakita, A; Yamada, M; Hayashi, S; Morita, T; Ikuta, F; Oyanagi, K; Takahashi, H


Enhanced SUMOylation in Polyglutamine disease
BBRC,293(1):307-313 2002
Author:Ueda, H; Goto, J; Hashida, H; Lin, X; Oyanagi, K; Kawano, H; Zoghbi, HY; Kanazawa, I; Okazawa, H


Alteration of midkine expressim in the isehemic brain of humans
J Neurological Sciences,200(1-2):67-73 2002
Author:Wada, M; Kamata, M; Aizu, Y; Morita, T; Hu, JG; Oyanagi, K


Degeneration of retinal neuronal processes and pigment epithelium in the early stage of the streptozotocirl-diabetic rats
Neuropathology,22(3):161-170 2002
Author:Aizu, Y; Oyanagi, K; Hu, JG; Nakagawa, H


Neuronal nuclear alterations in dentatorubural-pallidoluysian atrophy:ultrastructural and morphometric studies of the cerebellar granule cells
Brain Research,919(1):12-19 2001
Author:Takahashi, H; Egawa, S; Piao, YS; Hayashi, S; Yamada, M; Shimohata, T; Oyanagi, K; Tsuji, S


Progressive supranuclear palsy on Guam,
Acta Neuropathologica,102(5):510-514 2001
Author:Yamazaki,M., Makifuchi,T., Chen, K-M., Mori,O., Katayama,Y., Takahashi,H., Oyanagi,K.,


Distribution of basal ganglia lesions in generalized variant of Pick's disease: a clinicopathological study of four autopsy cases,
Acta Neuropathologica,102(5):441-448 2001
Author:Tsuchiya,K., Ishizu,H., Nakano,I., Kita,Y., Sawabe,M.,Haga,K., Kuyama,K., Nishinaka,T., Oyanagi,K., Ikeda,K., kuroda,S.,


Expression of calbindin D-28k and parvalbumin in cerebral cortical dysgenesis induced by administration of ethylnitrosourea to rats at the stage of neurogenesis,
Acta Neuropathologica,101(4):375-382 2001
Author:Oyanagi,K., Kakita,A., Kawasaki,K., Hayashi,S., Yamada,M.,


Substantia nigra in progressive supranuclear palsy, corticobasal degeneration, and parkinsonism-dementia complex of Guam: specific pathological features.,
J Neuropathol Exp Neurol,60(4):393-402 2001
Author:Oyanagi,K., Tsuchiya,K., Yamazaki,M., I,keda,K.,


Adenoviral gene transfer of glial cell line-derived neurotrophic factor to injured adult motoneurons.,
Hum Cell,14:7-15 2001
Author:Watabe,K., Sakamoto,T., Ohashi,T., Kawazoe,Y., Oyanagi,K., Takeshima,T., Inoue,K., Eto,Y., Kim,S.U.,


Establishment and characterization of immortalized Schwann cells from murine model of Niemann-Pick disease type C (spm/spm).,
J Peripher Nerv Syst,6(2):85-94 2001
Author:Watabe,K., Ida,H., Uehara,K., Oyanagi,K., Sakamoto,T., Tanaka,J., Garver,W.S., Miyawaki,S., Ohno,K., Eto,Y.,


Parkinsonism, dementia and vertical gaze palsy in a Guamanian with atypical neuroglial degeneration
Acta Neuropathol,99(1):73-80 2000
Author:Oyanagi, K., Chen, K-M., Craig, U.K., Yamazaki, M., Perl, D.P.,


alpha-synuclein inclusions in amygdala in the brains of patients with the parkinsonism-dementia complex of Guam
J Neuropathol Exp Neurol,59(7):585-591 2000
Author:Yamazaki, M., Arai, Y., Baba, M., Iwatsubo, T., Mori, O., Katayama, Y., Oyanagi, K.,


Endothelin-1 in the brain of patients with galactosialidosis: its abnormal increase and distribution pattern
Annals of Neurol,47(1):122-126 2000
Author:Itoh, K., Oyanagi, K., Takahashi, H., Sato, T., Hashizume, N., ShimmOtO, M., SakUraba, H.,


Amyotrophic lateral sclerosis: increased hyaluronic acid in the media of the basilar artery
J Neurol Sci,167(2):112-116 1999
Author:Oyanagi, K., Nagao, K., Ono, S.,


Pursuit of the origin of the large myelinated tibers of the anterolateral funiculus in the spinal cord in humans in relation to the pathomechanism in amyotrophic lateral sclerosis
Acta Neuropathologica,98(6):635-640 1999
Author:Oyanagi, K., Kawakami, E., Morita, T., Takahashi, H.


Variant Gerstmann-Straussler syndrome with the P1O5L pion gene mutation: an unusual case with nigral degeneration and widespread neurofibrillary tan・・・
Acta Neuropathologica,98(5):506-511 1999
Author:Yamazaki, M., Oyanagi, K., Mori, O., Kitamura, S., Ohyama, M., Terashi, A., Kitamoto, T., Katayama, Y.,


Bunina bodies in amyotrophic lateral sclerosis on Guam: a histochemical, immunohistochemical and ultrastructural investigation
Acta Neuropathologica,98(2):150-156 1999
Author:Wada,M.,Uchihara,T.,Nakamura,A.,Oyanagi,K.,