Doctor of Philosophy, Shinshu University

Biomedical engineering, Biomedical engineering

Nanobioscience, Nanobioscience

Orthopedics, Orthopedics

Pharmaceutical chemistry and drug development sciences, Pharmaceutical chemistry and drug development sciences

2015
Associate Professor Institute for Biomedical SciencesInterdisciplinary Cluster for Cutting Edge ReserchShinshu University

2013
Senior Assistant Professor Shinshu University, School of Medicine

2012
Assistant Professor Shinshu University, School of Medicine

2009 - 2011
Assistant Professor Shinshu University, Institute of Carbon Science and Technology

2007 - 2009
Assistant Professor Shinshu University, School of Medicine

1995 - 2007
Assistant Professor Shinshu University, School of Medicine

1993 - 1995
Yamanashi Medical University

2002 - 2005, Assistant Researcher Oklahoma University Health Sciences Center

1991, Kitasato University, Faculty of Hygienic Science, 衛生技術学科

1993, Kitasato University, Graduate School, Division of Hygienic Science, Clinical Chemistry

Lysophospholipids transport across blood-brain barrier in an in vitro reconstruction model.
Tsukahara T, Sasaki M, Haniu H, Matsuda Y.
Biochem Biophys Res Commun., 676, 91-96, Oct. 2023

Biocompatibility Evaluation of Carbon Nanohorns in Bone Tissues.
Ueda K, Ma C, Izumiya M, Kuroda C, Ishida H, Uemura T, Saito N, Aoki K, Haniu H.
Nanomaterials (Basel), 13(2), 244, Jan. 2023

Lysophospholipids: A Potential Drug Candidates for Neurodegenerative Disorders.
Karaki T, Haniu H, Matsuda Y. Tsukahara T,
BIOMEDICINES, 10(12), 3126, Dec. 2022

Lysophospholipids–potent candidates for brain food, protects neuronal cells against α-Synuclein aggregation.
Karaki T, Haniu H, Matsuda Y, Tsukahara T.
Biomed Pharmacother, 156, 113891, Dec. 2022

Future Prospects for Clinical Applications of Nanocarbons Focusing on Carbon Nanotubes.
Saito N, Haniu H, Aoki K, Nishimura N, Uemura T.
Adv Sci (Weinh), 9(24), e2201214, Aug. 2022

Current Methods in the Study of Nanomaterials for Bone Regeneration.
Tanaka M, Izumiya M, Haniu H, Ueda K, Ma C, Ueshiba K, Ideta H, Sobajima A, Uchiyama S, Takahashi J, Saito N.
Nanomaterials (Basel)., 12(7), 1195, Apr. 2022

Biokinetic Evaluation of Contrast Media Loaded Carbon Nanotubes Using a Radiographic Device.
Takasaka M, Kobayashi S, Usui Y, Haniu H, Tsuruoka S, Aoki K, Saito N.
Toxics, 9(12), 331, Dec. 2021

Antitumor Effect of Sclerostin against Osteosarcoma.
Ideta H, Yoshida K, Okamoto M, Sasaki J, Kito M, Aoki K, Yoshimura Y, Suzuki S, Tanaka A, Takazawa A, Haniu H, Uemura T, Takizawa T, Sobajima A, Kamanaka T, Takahashi J, Kato H, Saito N.
Cancers (Basel), 13, 6015, Nov. 2021

The Combined Effects of Lysophospholipids against Lipopolysaccharide-induced Inflammation and Oxidative Stress in Microglial Cells.
Tsukahara T, Hara H, Haniu H, Matsuda Y.
J Oleo Sci., 70, 947-954, Jul. 2021

Evaluation of MC3T3-E1 Cell Osteogenesis in Different Cell Culture Media
Izumiya M, Haniu M, Ueda K, Ishida H, Ma C, Ideta H, Sobajima A, Ueshiba K, Uemura T, Saito N, Haniu H.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(14), 7752, Jul. 2021
Corresponding

Abundant oleoyl-lysophosphatidylethanolamine in brain stimulates neurite outgrowth and protects against glutamate toxicity in cultured cortical neurons.
69. Hisano K, Yoshida H, Kawase S, Mimura T, Haniu H, Tsukahara T, Kurihara T, Matsuda Y, Saito N, Uemura T.
J Biochem., Apr. 2021

Isolated lymphatic vessel lumen perfusion system for assessing nanomaterial movements and nanomaterial-induced responses in lymphatic vessels.
Kuroda C, Ajima K, Ueda K, Sobajima A, Yoshida K, Kamanaka T, Sasaki J, Ishida H, Haniu H, Okamoto M, Aoki K. Kato H, Saito N.
Nano Today., 36(101018), Feb. 2021

Structurally different lysophosphatidylethanolamine species stimulate neurite outgrowth in cultured cortical neurons via distinct G-protein-coupled receptors and signaling cascades.
Hisano K, Kawase S, Mimura T, Yoshida H, Yamada H, Haniu H, Tsukahara T, Kurihara T, Matsuda Y, Saito N, Uemura T.
Biochem Biophys Res Commun., 534, 179-185, Jan. 2021

Multiwall Carbon Nanotube Composites as Artificial Joint Materials.
Sobajima A, Okihara T, Moriyama S, Nishimura N, Osawa T, Miyamae K, Haniu H, Aoki K, Tanaka M, Usui Y, Sako K, Kato H, Saito N.
ACS Biomater. Sci. Eng., 6, 7032-7040, Dec. 2020

Oral administration of porcine liver decomposition product for 4 weeks enhances visual memory and delayed recall in healthy adults over 40 years of age: A randomized, double-blind, placebo-controlled study.
Matsuda Y, Haniu H, Tsukahara T, Uemura T, Inoue T, Sako KI, Kojima J, Mori T, Sato K.
Exp Gerontol., 141, 111064, Nov. 2020

Therapeutic Potential of Porcine Liver Decomposition Product: New Insights and Perspectives for Microglia-Mediated Neuroinflammation in Neurodegenerative Diseases.
Tsukahara T, Haniu H, Uemura T, Matsuda Y.
Biomedicines., 8, 446, Oct. 2020

Carbon nanotube-based biomaterials for orthopaedic applications.
Aoki K, Ogihara N, Tanaka M, Haniu H, Saito N.
J Mater Chem B., 8, 9227-9238, Oct. 2020

Carbon fibers for treatment of cancer metastasis in bone.
Kamanaka T, Haniu H, Tanaka M, Takizawa T, Aoki K, Okamoto M, Sobajima A, Yoshida K, Ideta H, Mimura T, Ishida H, Ueda K, Uemura T, Kim JH, Kim YA, Kato H, Saito N.
RSC Adv., 10, 33071-33079, Sep. 2020

Porcine liver decomposition product-derived lysophospholipids promote microglial activation in vitro.
Tsukahara T, Haniu H, Uemura T, Matsuda Y.
Sci Rep., 10, 3748, 2020

Anti-PD-1 antibody decreases tumor-infiltrating regulatory T cells.
Yoshida K, Okamoto M, Sasaki J, Kuroda C, Ishida H, Ueda K, Ideta H, Kamanaka T, Sobajima A, Takizawa T, Tanaka M, Aoki K, Uemura T, Kato H, Haniu H, Saito N.
BMC CANCER, 20, 25, 2020

The Use of Electrospun Organic and Carbon Nanofibers in Bone Regeneration.
Aoki K, Haniu H, Kim YA, Saito N.
Nanomaterials (Basel)., 10, 562, 2020

Applications of Carbon Nanotubes in Bone Regenerative Medicine.
Tanaka M, Aoki K, Haniu H, Kamanaka T, Takizawa T, Sobajima A, Yoshida K, Okamoto M, Kato H, Saito N.
Nanomaterials (Basel)., 10, 659, 2020

Cellular Responses of Human Lymphatic Endothelial Cells to Carbon Nanomaterials.
Sano M, Izumiya M, Haniu H*, Ueda K, Konishi K, Ishida H, Kuroda C, Uemura T, Aoki K, Matsuda Y, Saito N.
Nanomaterials (Basel)., 10, 1374, 2020

Clinical outcome of osteosarcoma and its correlation with programmed death-ligand 1 and T cell activation markers.
Yoshida K, Okamoto M, Sasaki J, Kuroda C, Ishida H, Ueda K, Okano S, Ideta H, Kamanaka T, Sobajima A, Takizawa T, Kito M, Aoki K, Uemura T, Haniu H, Kato H, Saito N.
Oncotargets Ther., 12, 2513-2518, 2019

In Vitro and In Vivo Evaluation of Starfish Bone-Derived β-Tricalcium Phosphate as a Bone Substitute Material.
Ishida H, Haniu H, Takeuchi A, Ueda K, Sano M, Tanaka M, Takizawa T, Sobajima A, Kamanaka T, Saito N.
Materials (Basel)., 12, E1881, 2019

Organ accumulation and carcinogenicity of highly dispersed multi-walled carbon nanotubes administered intravenously in transgenic rasH2 mice.
Sobajima A, Haniu H, Nomura H, Tanaka M, Takizawa T, Kamanaka T, Aoki K, Okamoto M, Yoshida K, Sasaki J, Ajima K, Kuroda C, Ishida H, Okano S, Ueda K, Kato H, Saito N.
Int J Nanomedicine., 14, 6465-80, 2019

Different aggregation and shape characteristics of carbon materials affect biological responses in RAW264 cells
Kuroda Chika, Ueda Katsuya, Haniu Hisao, Ishida Haruka, Okano Satomi, Takizawa Takashi, Sobajima Atsushi, Kamanaka Takayuki, Yoshida Kazushige, Okamoto Masanori, Tsukahara Tamotsu, Matsuda Yoshikazu, Aoki Kaoru, Kato Hiroyuki, Saito Naoto
INTERNATIONAL JOURNAL OF NANOMEDICINE, 13, 6079-6088, 05 Oct. 2018

Titanium fiber plates for bone tissue repair.
Takizawa T, Nakayama N, Haniu H, Aoki K, Okamoto M, Nomura H, Tanaka M, Sobajima A, Yoshida K, Kamanaka T, Ajima K, Oishi A, Kuroda C, Ishida H, Okano S, Kobayashi S, Kato H, Saito N.
Adv Mater., 30, 1703608, 2018

Alkyl-glycerophosphate-mediated C-C motif chemokine 2 secretion induces oxidative stress via increased PPARγ activation in human umbilical vein endothelial cells.
Tsukahara T, Yamagishi S, Matsuda Y, Haniu H.
Biomed Pharmacother., 106, 686-691, 2018

The AGP-PPARγ axis promotes oxidative stress and diabetic endothelial cell dysfunction.
Tsukahara R, Haniu H, Matsuda Y, Tsukahara T.
Mol Cell Endocrinol., 473, 100-113, 2018

Physico-Chemical, in vitro, and in vivo evaluation of a 3D unidirectional porous hydroxyapatite scaffold for bone regeneration.
Tanaka M, Haniu H,Kamanaka T,Takizawa T, Sobajima A, Yoshida K, Aoki K, Okamoto M, Kato H, Saito N.
Materials (Basel)., 10, 33, 2017

A three-dimensional block structure consisting exclusively of carbon nanotubes serving as bone regeneration scaffold and as bone defect filler.
Tanaka M, Sato Y, Haniu H, Nomura H, Kobayashi S, Takanashi S, Okamoto M, Takizawa T, Aoki K, Usui Y, Oishi A, Kato H, Saito N.
PLOS ONE, 12, e0172601, 2017

In Vitro and In Vivo Evaluation of a Three-Dimensional Porous Multi-Walled Carbon Nanotube Scaffold for Bone Regeneration.
Tanaka M, Sato Y, Zhang M, Haniu H, Okamoto M, Aoki K, Takizawa T, Yoshida K, Sobajima A, Kamanaka T, Kato H, Saito N.
Nanomaterials, 7, 46, 2017

Lysophosphatidic acid signaling regulates the KLF9-PPARγ axis in human induced pluripotent stem cell-derived neurons.
Tsukahara T, Yamagishi S, Matsuda Y, Haniu H.
Biochem Biophys Res Commun., 491, 223-227, 2017

Lysophospholipid-related diseases and PPARγ signaling pathway.
Tsukahara T, Matsuda Y, Haniu H.
Int J Mol Sci., 18, 2730, 2017

Short-term treatment with a 2-carba analog of cyclic phosphatidic acid induces lowering of plasma cholesterol levels in ApoE-deficient mice.
Tsukahara T, Haniu H, Matsuda Y, Murakami-Murofushi K.
Biochem Biophys Res Commun., 473, 107-113, 2016

The dispersion state of tangled multi-walled carbon nanotubes affects their cytotoxicity.
Kuroda C, Haniu H, Ajima K, Tanaka M, Sobajima A, Ishida H, Tsukahara T, Matsuda Y, Aoki K, Kato H, Saito N.
Nanomaterials, 6, 2016, Refereed

An advanced in situ imaging method using heavy metal-doped hollow tubes to evaluate the biokinetics of carbon nanotubes in vivo
Kobayashi, Shinsuke; Tsuruoka, Shuji; Usui, Yuki; Haniu, Hisao; Aoki, Kaoru; Takanashi, Seiji; Okamoto, Masanori; Nomura, Hiroki; Tanaka, Manabu; Aiso, Shigetoshi; Saito, Misae; Kato, Hiroyuki; Saito, Naoto;
NPG Asia Materials, 7, Jul. 2015

CYCLIC PHOSPHATIDIC ACID INDUCES G(0/)G(1) ARREST, INHIBITS AKT PHOSPHORYLATION, AND DOWNREGULATES CYCLIN D1 EXPRESSION IN COLORECTAL CANCER CELLS
Tsukahara, T; Haniu, H; Matsuda, Y
CELLULAR & MOLECULAR BIOLOGY LETTERS, 20(1), 38-47, Mar. 2015

The Role of Autophagy as a Mechanism of Toxicity Induced by Multi-Walled Carbon Nanotubes in Human Lung Cells
Tsukahara, Tamotsu; Matsuda, Yoshikazu; Haniu, Hisao
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 16(1), 40-48, Jan. 2015

Cyclic phosphatidic acid inhibits the secretion of vascular endothelial growth factor from diabetic human coronary artery endothelial cells through peroxisome proliferator-activated receptor gamma.
Tsukahara T, Tsukahara R, Haniu H, Matsuda Y, Murakami-Murofushi K.
Mol Cell Endocrinol., 412, 320-329, 2015

Specific biological responses of the synovial membrane to carbon nanotubes
Nomura, Hiroki; Takanashi, Seiji; Tanaka, Manabu; Haniu, Hisao; Aoki, Kaoru; Okamoto, Masanori; Kobayashi, Shinsuke; Takizawa, Takashi; Usui, Yuki; Oishi, Ayumu; Kato, Hiroyuki; Saito, Naoto;
SCIENTIFIC REPORTS, 5, 2015

Endocytosis of Multiwalled Carbon Nanotubes in Bronchial Epithelial and Mesothelial Cells
Maruyama, K; Haniu, H; Saito, N; Matsuda, Y; Tsukahara, T; Kobayashi, S; Tanaka, M; Aoki, K; Takanashi, S; Okamoto, M; Kato, H
BioMed Research International, 2015, 793186, 2015

Two-Dimensional Gel-Based Protein Standardization Verified by Western Blot Analysis
Haniu, Hisao; Watanabe, Daisuke; Kawashima, Yusuke; Matsumoto, Hiroyuki
Methods in Molecular Biology, 1312, 473-479, 2015

Biological responses according to the shape and size of carbon nanotubes in BEAS-2B and MESO-1 cells
Haniu, H; Saito, N; Matsuda, Y; Tsukahara, T; Usui, Y; Maruyama, K; Takanashi, S; Aoki, K; Kobayashi, S; Nomura, H; Tanaka, M; Okamoto, M; Kato, H
INTERNATIONAL JOURNAL OF NANOMEDICINE, 9, 1979-1990, 2014

Heart-type fatty-acid-binding protein (FABP3) is a lysophosphatidic acid-binding protein in human coronary artery endothelial cells
Tsukahara, Ryoko; Haniu, Hisao; Matsuda, Yoshikazu; Tsukahara, Tamotsu
FEBS Open Bio, 4, 947-951, 2014

Cyclic Phosphatidic Acid Inhibits Alkyl-Glycerophosphate-Induced Downregulation of Histone Deacetylase 2 Expression and Suppresses the Inflammatory Response in Human Coronary Artery Endothelial Cells
Tsukahara, Tamotsu; Haniu, Hisao; Matsuda, Yoshikazu
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 11(9), 955-961, 2014

Cyclic Phosphatidic Acid Stimulates cAMP Production and Inhibits Growth in Human Colon Cancer Cells
Tsukahara, T; Matsuda, Y; Haniu, H
PLOS ONE, 8(11), e81139, Nov. 2013

Highly purified, multi-wall carbon nanotubes induce light-chain 3B expression in human lung cells
Tsukahara Tamotsu, Matsuda Yoshikazu, Usui Yuki, Haniu Hisao
Biochemical and biophysical research communications, 440(2), 348-353, 18 Oct. 2013

Culture medium type affects endocytosis of multi-walled carbon nanotubes in BEAS-2B cells and subsequent biological response
Haniu, Hisao; Saito, Naoto; Matsuda, Yoshikazu; Tsukahara, Tamotsu; Maruyama, Kayo; Usui, Yuki; Aoki, Kaoru; Takanashi, Seiji; Kobayashi, Shinsuke; Nomura, Hiroki; Okamoto, Masanori; Shimizu, Masayuki; Kato, Hiroyuki
Toxicology in Vitro, 27(6), 1679-1685, Sep. 2013

PTB-associated splicing factor (PSF) is a PPARγ-binding protein and growth regulator of colon cancer cells.
Tsukahara T, Haniu H, Matsuda Y.
PLOS ONE, 8, e58749, 2013

Effect of alkyl glycerophosphate on the activation of peroxisome proliferator-activated receptor gamma and glucose uptake in C2C12 cells.
Tsukahara T, Haniu H, Matsuda Y.
Biochem Biophys Res Commun., 433, 281-285, 2013

PSF Knockdown Enhances Apoptosis via Downregulation of LC3B in Human Colon Cancer Cells
Tsukahara, T; Matsuda, Y; Haniu, H
BioMed Research International, 2013, 204973, 2013

Two-dimensional gel electrophoresis: glass tube-based IEF followed by SDS-PAGE.
Matsumoto H, Haniu H, Kurien BT, Komori N.
Methods Mol Biol., 869, 267-273, 2012

Lysophosphatidic Acid Stimulates MCP-1 Secretion From C2C12 Myocytes.
Tsukahara T, Haniu H.
ISRN Inflamm., 2012, 983420, 2012

Carbon Nanotubes Innovate on Medical Technology.
Usui Y, Haniu H, Tsuruoka S, Saito N.
Med Chem., 2, 105, 2012

Carbon nanotubes induce bone calcification by bidirectional interaction with osteoblasts.
Shimizu M, Kobayashi Y, Mizoguchi T, Nakamura H, Kawahara I, Narita N, Usui Y, Aoki K, Hara K, Haniu H, Ogihara N, Ishigaki N, Nakamura K, Kato H, Kawakubo M, Dohi Y, Taruta S, Kim YA, Endo M, Ozawa H, Udagawa N, Takahashi N, Saito N.
Adv Mater., 24, 2176-2185, 2012

Peroxisome proliferator-activated receptor gamma overexpression suppresses proliferation of human colon cancer cells.
Tsukahara T, Haniu H.
Biochem Biophys Res Commun., 424, 524-529, 2012

Manufacturing Strategy for Multiwalled Carbon Nanotubes as a Biocompatible and Innovative Material
Haniu, Hisao; Saito, Naoto; Matsuda, Yoshikazu; Usui, Yuki; Aoki, Kaoru; Shimizu, Masayuki; Ogihara, Nobuhide; Hara, Kazuo; Takanashi, Seiji; Okamoto, Masanori; Nakamura, Koichi; Ishigaki, Norio; Tsukahara, Tamotsu; Kato, Hiroyuki
Journal of Nanotechnology, 2012, 937819, 2012

Basic Potential of Carbon Nanotubes in Tissue Engineering Applications
Haniu, Hisao; Saito, Naoto; Matsuda, Yoshikazu; Tsukahara, Tamotsu; Usui, Yuki; Narita, Nobuyo; Hara, Kazuo; Aoki, Kaoru; Shimizu, Masayuki; Ogihara, Nobuhide; Takanashi, Seiji; Okamoto, Masanori; Kobayashi, Shinsuke; Ishigaki, Norio; Nakamura, Koichi; Kato, Hiroyuki
Journal of Nanomaterials, 2012, 343747, 2012

Biocompatibility and bone tissue compatibility of alumina ceramics reinforced with carbon nanotubes.
Ogihara N, Usui Y, Aoki K, Shimizu M, Narita N, Hara K, Nakamura K, Ishigaki N, Takanashi S, Okamoto M, Kato H, Haniu H, Ogiwara N, Nakayama N, Taruta S, Saito N.
Nanomedicine (Lond)., 7, 981-993, 2012

Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice.
Takanashi S, Hara K, Aoki K, Usui Y, Shimizu M, Haniu H, Ogihara N, Ishigaki N, Nakamura K, Okamoto M, Kobayashi S, Kato H, Sano K, Nishimura N, Tsutsumi H, Machida K, Saito N.
Sci Rep., 2, 498, 2012

Elucidation mechanism of different biological responses to multi-walled carbon nanotubes using four cell lines
Haniu, Hisao; Saito, Naoto; Matsuda, Yoshikazu; Kim, Yoong-Ahm; Park, Chul Ki; Tsukahara, Tamotsu; Usui, Yuki; Aoki, Kaoru; Shimizu, Masayuki; Ogihara, Nobuhide; Hara, Kazuo; Takanashi, Seiji; Okamoto, Masanori; Ishigaki, Norio; Nakamura, Koichi; Kato, Hiroyuki
INTERNATIONAL JOURNAL OF NANOMEDICINE, 6(1), 3487-3497, Dec. 2011

Effect of dispersants of multi-walled carbon nanotubes on cellular uptake and biological responses
Haniu, Hisao; Saito, Naoto;Matsuda, Yoshikazu; Kim, Yoong-Ahm; Park, Chul Ki; Tsukahara, Tamotsu; Usui, Yuki; Aoki, Kaoru; Shimizu, Masayuki; Ogihara, Nobuhide; Hara, Kazuo; Takanashi, Seiji; Okamoto, Masanori; Ishigaki, Norio; Nakamura, Koichi; Kato, Hiroyuki
INTERNATIONAL JOURNAL OF NANOMEDICINE, 6(1), 3295-3307, Dec. 2011

Toxicoproteomic evaluation of carbon nanomaterials in vitro
Haniu, Hisao; Matsuda, Yoshikazu; Usui, Yuki; Aoki, Kaoru; Shimizu, Masayuki; Ogihara, Nobuhide; Hara, Kazuo; Okamoto, Masanori; Takanashi, Seiji; Ishigaki, Norio; Nakamura, Koichi; Kato, Hiroyuki; Saito, Naoto
JOURNAL OF PROTEOMICS, 74(12), 2703-2712, Nov. 2011

DJ-1 as a potential biomarker for the development of biocompatible multiwalled carbon nanotubes
Haniu, Hisao; Tsukahara, Tamotsu; Matsuda, Yoshikazu; Usui, Yuki; Aoki, Kaoru; Shimizu, Masayuki; Ogihara, Nobuhide; Hara, Kazuo; Takanashi, Seiji; Okamoto, Masanori; Ishigaki, Norio; Nakamura, Koichi; Kato, Hiroyuki; Saito, Naoto
INTERNATIONAL JOURNAL OF NANOMEDICINE, 6(1), 2689-2695, Nov. 2011

Cellular cytotoxic response induced by highly purified multi-wall carbon nanotube in human lung cells
Tsukahara, Tamotsu; Haniu, Hisao
Molecular and Cellular Biochemistry, 352(1-2), 57-63, Jun. 2011

Nanoparticle-mediated intracellular lipid accumulation during C2C12 cell differentiation
Tsukahara, Tamotsu; Haniu, Hisao
Biochemical and biophysical research communications, 406(4), 558-563, Mar. 2011

The Application of Proteomics to PK-PD Modeling and Simulation.
Sako K, Haniu H, Hasegawa M, et al
J Bioequiv Availab, 2011, S2-002, 2011

Application of carbon fibers to biomaterials: A new era of nano-level control of carbon fibers after 30-years of development
Saito, Naoto; Aoki, Kaoru; Usui, Yuki; Shimizu, Masayuki; Hara, Kazuo; Narita, Nobuyo; Ogihara, Nobuhide; Nakamura, Koichi; Ishigaki, Norio; Kato, Hiroyuki; Haniu, Hisao; Taruta, Seiichi; Kim, Yoong Ahm; Endo, Morinobu
CHEMICAL SOCIETY REVIEWS, 40(7), 3824-3834, 2011

Evaluation of CNT toxicity in comparison to tattoo ink nanoparticles for use as a biomaterial.
Hara K, Kaoru Aoki K, Usui Y, Shimizu M, Narita N, Ogihara N, Nakamura K, Ishigaki N, Sano K, Haniu H, Kato H, Nishimura N, Kim YA, Taruta S, Saito N.
Mater Today., 14, 434-440, 2011

Proteomics-based safety evaluation of multi-walled carbon nanotubes
Haniu, H; Matsuda, Y; Takeuchi, K; Kim, YA; Hayashi, T; Endo, M
Toxicology and Applied Pharmacology, 242(3), 256-262, Feb. 2010

Effect of Lecithin: Cholesterol Acyltransferase on the Formation of Cross-linked Apolipoprotein AI.
Kurosaki Y, Ikeya H, Haniu H, et al
J Ana Bio-Sci, 33, 151-160, 2010

Potential of a Novel Safety Evaluation of Nanomaterials Using a Proteomic Approach
Haniu,Hisao; Matsuda,Yoshikazu; Takeuchi,Kenji
Journal of health science, 55(3), 428-434, Jun. 2009

Proteome Profiling of Vitreoretinal Diseases by Cluster Analysis.
Shitama, T; Hayashi, H; Noge, S; Uchio, E; Oshima, K; Haniu, H;Takemori, N; Komori, N; Matsumoto, H
Proteomics Clin Appl, 2, 1265-1280, 2008

Role of systemic T-cells and histopathological aspects after subcutaneous implantation of various carbon nanotubes in mice
Koyama, S; Endo, M; Kim, YA; Hayashi, T; Yanagisawa, T; Osaka, K; Koyama, H; Haniu, H; Kuroiwa, N
Carbon, 44(6), 1079-1092, 2006

Medical application of carbon-nanotube-fitted nanocomposites: The microcatheter
Koyama, S; Haniu, H; Osaka, K; Koyama, H; Kuroiwa, N; Endo, M; Kim, YA; Hayashi, T
SMALL, 2(12), 1406-1411, 2006

Proteomic trajectory mapping of biological transformation: Application to developmental mouse retina
Haniu, H; Komori, N; Takemori, N; Singh, A; Ash, JD; Matsumoto, H
PROTEOMICS, 6(11), 3251-3261, 2006

Identification of 4-hydroxynonenal-modified retinal proteins induced by photooxidative stress prior to retinal degeneration.
Tanito, M; Haniu, H; Elliott,MH; Singh, AK; Matsumoto, H; Anderson, RE
Free Radic Biol Med, 41, 1847-1859, 2006

Developmental proteomics of mouse retina.
Haniu, H; Singh, A; Komori, N; Ash, JD; Koyama, S; Matsumoto, H
INVESTIGATIVE OPHTHALMOLOGY&VISUAL SCIENCE, 45, U318-U318, 2004

Cell growing with activated carbon fivers - Significances of porous size
Koyama S, Haniu H, Takeichi T, Tanaka S, Yamaguchi Y, Konishi G, Koyama H
Mol Cryst Liq Cryst, 388, 173-176, 2002

Inhibition of cell cycle and induction of apoptosis due to modified C60 on HL-60 promyelocytic leukemic cells and it's macrophage-like cells
Koyama S, Haniu H, Tanaka S, Yamaguchi Y, Konishi G, Koyama H
Mol Cryst Liq Cryst, 386, 21-24, 2002

Different tissue reactions to activated carbon fivers - Pathological and immunological findings after subcutaneous implantation
Koyama S, Tanaka S, Yamaguchi Y, Haniu H, Konishi G, Koyama H
Mol Cryst Liq Cryst, 388, 109-115, 2002

Presinusoidal vessels predominantly contract in response to norepinephrine, histamine, and KC1 in rabbit Liver
Shibamoto, T; Wang, HG; Miyahara, T; Tanaka, S; Haniu, H; Koyama, S
JOURNAL OF APPLIED PHYSIOLOGY, 87(4), 1404-1412, 1999

Yoshixol(TR) inhibits B16 melanoma cell growth in vivo and induces apoptosis-like (quantum thermodynamic) cell death
Koyama, S; Tanaka, S; Haniu, H; Yamaguchi, Y; Motoyoshiya, J
GENERAL PHARMACOLOGY, 33(2), 161-172, 1999

In vitro and in vivo antiturnor activity of Yoshixol(TR) against murine L1210 leukemic cells
Tanaka, S; Koyama, S; Haniu, H; Yamaguchi, Y; Motoyoshiya, J
GENERAL PHARMACOLOGY, 33(2), 179-186, 1999

Effect of ONO-5046, a specific neutrophil elastase inhibitor, on the phorbol myristate acetate-induced injury in isolated dog lung
Wang, HG; Shibamoto, T; Miyahara, T; Haniu, H; Tanaka, S; Fujimoto, K; Honda, T; Kubo, K; Koyama, S
EXPERIMENTAL LUNG RESEARCH, 25(1), 55-67, 1999

カーボンナノチューブ
羽二生久夫, 鶴岡秀志, 齋藤直人, カーボンナノチューブの安全性評価.
㈱技術情報協会, 447-456 2019

カーボンナノチューブ・グラフェンハンドブック
薄井雄企, 青木薫, 羽二生久夫　他
コロナ社, 282-289 2011

In Advances in Medicine&Biology 11
Saito N, Aoki K, Usui Y, Shimizu M, Hara K, Narita N, Ogihara N, Nakamura K, Ishigaki N,Kato H, Haniu H, Kim C, Taruta S, Kim YA, Endo M., Thin Carbon Fiber Web that Functions as a Scaffold for Tissue Regeneration.
Nova Science Publishers Inc, 301-310 2011

Bone Regeneration: Growth Factors, Augmentation Procedures and Tissue Engineering Applications
Saito N, Usui Y, Aoki K, Narita N, Shimizu M, Hara K, Ogihara N, Nakamura K, Ishigaki N, Kato H, Haniu H, Taruta S, Endo M., Application of carbon nanotubes on scaffolds for bone tissue regeneration.
Nova Science Publishers, 275-284 2010

2012 - 2018
SOCIETY FOR REGULATORY SCIENCE OF MEDICAL PRODUCTS

2009
Japan Human Proteome Organization

2009
The Japanese Society of Toxicology

2016
Japanese Society for Biomaterials

Safety evaluation of nanomaterials

Biomedical application of nanomaterials

Bone prosthesis by cultured cells

Developing a treatment for spinal cord injury