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HANIU HISAO

Academic OrganizationAcademic Assembly School of Medicine and Health Sciences Institute of MedicineTEL+81-263-37-3555
Education and Research OrganizationInterdisciplinary Cluster for Cutting Edge Research, Institute for Biomedical Sciences , Department of Biotechnology and Biomedical EngineeringFAX+81-263-37-3549
PositionAssistant ProfessorMail Addresshhaniu@shinshu-u.ac.jp
Address3-1-1 Asahi, Matsumoto, Nagano 390-8621Web site

Modified:08/09/2019

Profile

Research Field
Biotechnology・Biomaterials
Nanobioscience
Risk sciences of radiation and chemicals
Environmental impact assessment
Current Subject
Safety evaluation of carbon nanotube
Keywords:Carbon nanotube , Proteomics , Cytotoxicity
Academic Societies
Academic Societies
Japanese Society for Biomaterials
Japan Human Proteome Organization
The Japanese Society of Toxicology
SOCIETY FOR REGULATORY SCIENCE OF MEDICAL PRODUCTS
Academic Background
Graduate School
Kitasato University , (Clinical Chemistry , Graduate School, Division of Hygienic Science) , 1993

College
Kitasato University , (Faculty of Hygienic Science) , 1991

Degree
Doctor of Philosophy , Shinshu University
Research Career
Research Career
2015- , Associate Professor Institute for Biomedical SciencesInterdisciplinary Cluster for Cutting Edge ReserchShinshu University
2013- , Senior Assistant Professor Shinshu University, School of Medicine
2012- , Assistant Professor Shinshu University, School of Medicine
2009-2011 , Assistant Professor Shinshu University, Institute of Carbon Science and Technology
2007-2009 , Assistant Professor Shinshu University, School of Medicine
1995-2007 , Assistant Professor Shinshu University, School of Medicine
1993-1995 , Yamanashi Medical University

Overseas Education
2002-2005 , Assistant Researcher Oklahoma University Health Sciences Center

Research

Books, Articles, etc.
Books
Thin Carbon Fiber Web that Functions as a Scaffold for Tissue Regeneration.
Nova Science Publishers Inc , In Advances in Medicine&Biology , 11:301-310 2011
Author:Saito N, Aoki K, Usui Y, Shimizu M, Hara K, Narita N, Ogihara N, Nakamura K, Ishigaki N,Kato H, Haniu H, Kim C, Taruta S, Kim YA, Endo M.


カーボンナノチューブ・グラフェンハンドブック
コロナ社 , :282-289 2011
Author:薄井雄企, 青木薫, 羽二生久夫 他


Application of carbon nanotubes on scaffolds for bone tissue regeneration.
Nova Science Publishers , Bone Regeneration: Growth Factors, Augmentation Procedures and Tissue Engineering Applications , :275-284 2010
Author:Saito N, Usui Y, Aoki K, Narita N, Shimizu M, Hara K, Ogihara N, Nakamura K, Ishigaki N, Kato H, Haniu H, Taruta S, Endo M.


Articles
Different aggregation and shape characteristics of carbon materials affect biological responses in RAW264 cells
INTERNATIONAL JOURNAL OF NANOMEDICINE,13:6079-6088 2018(Oct. 05)
Author:Kuroda Chika, Ueda Katsuya, Haniu Hisao, Ishida Haruka, Okano Satomi, Takizawa Takashi, Sobajima Atsushi, Kamanaka Takayuki, Yoshida Kazushige, Okamoto Masanori, Tsukahara Tamotsu, Matsuda Yoshikazu, Aoki Kaoru, Kato Hiroyuki, Saito Naoto


The AGP-PPARγ axis promotes oxidative stress and diabetic endothelial cell dysfunction.
Mol Cell Endocrinol.,473:100-113 2018
Author:Tsukahara R, Haniu H, Matsuda Y, Tsukahara T.


Alkyl-glycerophosphate-mediated C-C motif chemokine 2 secretion induces oxidative stress via increased PPARγ activation in human umbilical vein endothelial cells.
Biomed Pharmacother.,106:686-691 2018
Author:Tsukahara T, Yamagishi S, Matsuda Y, Haniu H.


Titanium fiber plates for bone tissue repair.
Adv Mater.,30:1703608 2018
Author:Takizawa T, Nakayama N, Haniu H, Aoki K, Okamoto M, Nomura H, Tanaka M, Sobajima A, Yoshida K, Kamanaka T, Ajima K, Oishi A, Kuroda C, Ishida H, Okano S, Kobayashi S, Kato H, Saito N.


Lysophospholipid-related diseases and PPARγ signaling pathway.
Int J Mol Sci.,18:2730 2017
Author:Tsukahara T, Matsuda Y, Haniu H.


Lysophosphatidic acid signaling regulates the KLF9-PPARγ axis in human induced pluripotent stem cell-derived neurons.
Biochem Biophys Res Commun.,491:223-227 2017
Author:Tsukahara T, Yamagishi S, Matsuda Y, Haniu H.


In Vitro and In Vivo Evaluation of a Three-Dimensional Porous Multi-Walled Carbon Nanotube Scaffold for Bone Regeneration.
Nanomaterials,7:46 2017
Author:Tanaka M, Sato Y, Zhang M, Haniu H, Okamoto M, Aoki K, Takizawa T, Yoshida K, Sobajima A, Kamanaka T, Kato H, Saito N.


A three-dimensional block structure consisting exclusively of carbon nanotubes serving as bone regeneration scaffold and as bone defect filler.
PLoS One,12:e0172601 2017
Author:Tanaka M, Sato Y, Haniu H, Nomura H, Kobayashi S, Takanashi S, Okamoto M, Takizawa T, Aoki K, Usui Y, Oishi A, Kato H, Saito N.


Physico-Chemical, in vitro, and in vivo evaluation of a 3D unidirectional porous hydroxyapatite scaffold for bone regeneration.
Materials,10:33 2017
Author:Tanaka M, Haniu H,Kamanaka T,Takizawa T, Sobajima A, Yoshida K, Aoki K, Okamoto M, Kato H, Saito N.


ブタ肝臓分解物のヒト認知機能改善効果.
医学と薬学,73:1057-1066 2016
Author:松田佳和, 羽二生久夫, 塚原完, 井上俊夫, 佐古兼一, 杉田和夫, 馬渕知子, 江水保, 佐藤和三郎.


ラットの空間認知記憶に及ぼすコリン塩化物長期摂取の影響.
医学と薬学,73:1009-1016 2016
Author:井上俊夫, 松田佳和, 佐藤卓美, 櫻田誓, 羽二生久夫, 塚原完, 杉田和夫, 馬渕知子, 江水保, 佐藤和三郎.


The dispersion state of tangled multi-walled carbon nanotubes affects their cytotoxicity.
Nanomaterials,6 2016
Author:Kuroda C, Haniu H, Ajima K, Tanaka M, Sobajima A, Ishida H, Tsukahara T, Matsuda Y, Aoki K, Kato H, Saito N.


Short-term treatment with a 2-carba analog of cyclic phosphatidic acid induces lowering of plasma cholesterol levels in ApoE-deficient mice.
Biochem Biophys Res Commun.,473:107-113 2016
Author:Tsukahara T, Haniu H, Matsuda Y, Murakami-Murofushi K.


An advanced in situ imaging method using heavy metal-doped hollow tubes to evaluate the biokinetics of carbon nanotubes in vivo
NPG ASIA MATERIALS,7:- 2015(Jul.)
Author:Kobayashi, Shinsuke; Tsuruoka, Shuji; Usui, Yuki; Haniu, Hisao; Aoki, Kaoru; Takanashi, Seiji; Okamoto, Masanori; Nomura, Hiroki; Tanaka, Manabu; Aiso, Shigetoshi; Saito, Misae; Kato, Hiroyuki; Saito, Naoto;


CYCLIC PHOSPHATIDIC ACID INDUCES G(0/)G(1) ARREST, INHIBITS AKT PHOSPHORYLATION, AND DOWNREGULATES CYCLIN D1 EXPRESSION IN COLORECTAL CANCER CELLS
CELLULAR & MOLECULAR BIOLOGY LETTERS,20(1):38-47 2015(Mar.)
Author:Tsukahara, T; Haniu, H; Matsuda, Y


The Role of Autophagy as a Mechanism of Toxicity Induced by Multi-Walled Carbon Nanotubes in Human Lung Cells
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,16(1):40-48 2015(Jan.)
Author:Tsukahara, Tamotsu; Matsuda, Yoshikazu; Haniu, Hisao


Cyclic phosphatidic acid inhibits the secretion of vascular endothelial growth factor from diabetic human coronary artery endothelial cells through peroxisome proliferator-activated receptor gamma.
Mol Cell Endocrinol.,412:320-329 2015
Author:Tsukahara T, Tsukahara R, Haniu H, Matsuda Y, Murakami-Murofushi K.


Specific biological responses of the synovial membrane to carbon nanotubes
SCIENTIFIC REPORTS,5:- 2015
Author:Nomura, Hiroki; Takanashi, Seiji; Tanaka, Manabu; Haniu, Hisao; Aoki, Kaoru; Okamoto, Masanori; Kobayashi, Shinsuke; Takizawa, Takashi; Usui, Yuki; Oishi, Ayumu; Kato, Hiroyuki; Saito, Naoto;


Two-Dimensional Gel-Based Protein Standardization Verified by Western Blot Analysis
Methods in Molecular Biology ,1312:473-479 2015
Author:Haniu, Hisao; Watanabe, Daisuke; Kawashima, Yusuke; Matsumoto, Hiroyuki


Endocytosis of Multiwalled Carbon Nanotubes in Bronchial Epithelial and Mesothelial Cells
BIOMED RESEARCH INTERNATIONAL,2015:793186 2015
Author:Maruyama, K; Haniu, H; Saito, N; Matsuda, Y; Tsukahara, T; Kobayashi, S; Tanaka, M; Aoki, K; Takanashi, S; Okamoto, M; Kato, H


Cyclic Phosphatidic Acid Inhibits Alkyl-Glycerophosphate-Induced Downregulation of Histone Deacetylase 2 Expression and Suppresses the Inflammatory Response in Human Coronary Artery Endothelial Cells
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES,11(9):955-961 2014
Author:Tsukahara, Tamotsu; Haniu, Hisao; Matsuda, Yoshikazu


Heart-type fatty-acid-binding protein (FABP3) is a lysophosphatidic acid-binding protein in human coronary artery endothelial cells
FEBS OPEN BIO,4:947-951 2014
Author:Tsukahara, Ryoko; Haniu, Hisao; Matsuda, Yoshikazu; Tsukahara, Tamotsu


Biological responses according to the shape and size of carbon nanotubes in BEAS-2B and MESO-1 cells
INTERNATIONAL JOURNAL OF NANOMEDICINE,9:1979-1990 2014
Author:Haniu, H; Saito, N; Matsuda, Y; Tsukahara, T; Usui, Y; Maruyama, K; Takanashi, S; Aoki, K; Kobayashi, S; Nomura, H; Tanaka, M; Okamoto, M; Kato, H


Cyclic Phosphatidic Acid Stimulates cAMP Production and Inhibits Growth in Human Colon Cancer Cells
PLOS ONE,8(11):e81139 2013(Nov.)
Author:Tsukahara, T; Matsuda, Y; Haniu, H


Highly purified, multi-wall carbon nanotubes induce light-chain 3B expression in human lung cells
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,440(2):348-353 2013(Oct. 18)
Author:Tsukahara Tamotsu, Matsuda Yoshikazu, Usui Yuki, Haniu Hisao


Culture medium type affects endocytosis of multi-walled carbon nanotubes in BEAS-2B cells and subsequent biological response
Toxicology in Vitro,27(6):1679-1685 2013(Sep.)
Author:Haniu, Hisao; Saito, Naoto; Matsuda, Yoshikazu; Tsukahara, Tamotsu; Maruyama, Kayo; Usui, Yuki; Aoki, Kaoru; Takanashi, Seiji; Kobayashi, Shinsuke; Nomura, Hiroki; Okamoto, Masanori; Shimizu, Masayuki; Kato, Hiroyuki


PSF Knockdown Enhances Apoptosis via Downregulation of LC3B in Human Colon Cancer Cells
BIOMED RESEARCH INTERNATIONAL,2013:204973 2013
Author:Tsukahara, T; Matsuda, Y; Haniu, H


Effect of alkyl glycerophosphate on the activation of peroxisome proliferator-activated receptor gamma and glucose uptake in C2C12 cells.
Biochem Biophys Res Commun.,433:281-285 2013
Author:Tsukahara T, Haniu H, Matsuda Y.


PTB-associated splicing factor (PSF) is a PPARγ-binding protein and growth regulator of colon cancer cells.
PLoS One,8:e58749 2013
Author:Tsukahara T, Haniu H, Matsuda Y.


Carbon Nanotubes Innovate on Medical Technology.
Med Chem.,2:105 2012
Author:Usui Y, Haniu H, Tsuruoka S, Saito N.


Lysophosphatidic Acid Stimulates MCP-1 Secretion From C2C12 Myocytes.
ISRN Inflamm.,2012:983420 2012
Author:Tsukahara T, Haniu H.


Peroxisome proliferator-activated receptor gamma overexpression suppresses proliferation of human colon cancer cells.
Biochem Biophys Res Commun.,424:524-529 2012
Author:Tsukahara T, Haniu H.


Two-dimensional gel electrophoresis: glass tube-based IEF followed by SDS-PAGE.
Methods Mol Biol.,869:267-273 2012
Author:Matsumoto H, Haniu H, Kurien BT, Komori N.


Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice.
Sci Rep.,2:498 2012
Author:Takanashi S, Hara K, Aoki K, Usui Y, Shimizu M, Haniu H, Ogihara N, Ishigaki N, Nakamura K, Okamoto M, Kobayashi S, Kato H, Sano K, Nishimura N, Tsutsumi H, Machida K, Saito N.


Carbon nanotubes induce bone calcification by bidirectional interaction with osteoblasts.
Adv Mater.,24:2176-2185 2012
Author:Shimizu M, Kobayashi Y, Mizoguchi T, Nakamura H, Kawahara I, Narita N, Usui Y, Aoki K, Hara K, Haniu H, Ogihara N, Ishigaki N, Nakamura K, Kato H, Kawakubo M, Dohi Y, Taruta S, Kim YA, Endo M, Ozawa H, Udagawa N, Takahashi N, Saito N.


Biocompatibility and bone tissue compatibility of alumina ceramics reinforced with carbon nanotubes.
Nanomedicine (Lond).,7:981-993 2012
Author:Ogihara N, Usui Y, Aoki K, Shimizu M, Narita N, Hara K, Nakamura K, Ishigaki N, Takanashi S, Okamoto M, Kato H, Haniu H, Ogiwara N, Nakayama N, Taruta S, Saito N.


Basic Potential of Carbon Nanotubes in Tissue Engineering Applications
Journal of Nanomaterials,2012:343747 2012
Author:Haniu, Hisao; Saito, Naoto; Matsuda, Yoshikazu; Tsukahara, Tamotsu; Usui, Yuki; Narita, Nobuyo; Hara, Kazuo; Aoki, Kaoru; Shimizu, Masayuki; Ogihara, Nobuhide; Takanashi, Seiji; Okamoto, Masanori; Kobayashi, Shinsuke; Ishigaki, Norio; Nakamura, Koichi; Kato, Hiroyuki


Manufacturing Strategy for Multiwalled Carbon Nanotubes as a Biocompatible and Innovative Material
Journal of Nanotechnology,2012:937819 2012
Author:Haniu, Hisao; Saito, Naoto; Matsuda, Yoshikazu; Usui, Yuki; Aoki, Kaoru; Shimizu, Masayuki; Ogihara, Nobuhide; Hara, Kazuo; Takanashi, Seiji; Okamoto, Masanori; Nakamura, Koichi; Ishigaki, Norio; Tsukahara, Tamotsu; Kato, Hiroyuki


Elucidation mechanism of different biological responses to multi-walled carbon nanotubes using four cell lines
International Journal of Nanomedicine,6(1):3487-3497 2011(Dec.)
Author:Haniu, Hisao; Saito, Naoto; Matsuda, Yoshikazu; Kim, Yoong-Ahm; Park, Chul Ki; Tsukahara, Tamotsu; Usui, Yuki; Aoki, Kaoru; Shimizu, Masayuki; Ogihara, Nobuhide; Hara, Kazuo; Takanashi, Seiji; Okamoto, Masanori; Ishigaki, Norio; Nakamura, Koichi; Kato, Hiroyuki


Effect of dispersants of multi-walled carbon nanotubes on cellular uptake and biological responses
International Journal of Nanomedicine,6(1):3295-3307 2011(Dec.)
Author:Haniu, Hisao; Saito, Naoto;Matsuda, Yoshikazu; Kim, Yoong-Ahm; Park, Chul Ki; Tsukahara, Tamotsu; Usui, Yuki; Aoki, Kaoru; Shimizu, Masayuki; Ogihara, Nobuhide; Hara, Kazuo; Takanashi, Seiji; Okamoto, Masanori; Ishigaki, Norio; Nakamura, Koichi; Kato, Hiroyuki


DJ-1 as a potential biomarker for the development of biocompatible multiwalled carbon nanotubes
International Journal of Nanomedicine,6(1):2689-2695 2011(Nov.)
Author:Haniu, Hisao; Tsukahara, Tamotsu; Matsuda, Yoshikazu; Usui, Yuki; Aoki, Kaoru; Shimizu, Masayuki; Ogihara, Nobuhide; Hara, Kazuo; Takanashi, Seiji; Okamoto, Masanori; Ishigaki, Norio; Nakamura, Koichi; Kato, Hiroyuki; Saito, Naoto


Toxicoproteomic evaluation of carbon nanomaterials in vitro
Journal of Proteomics,74(12):2703-2712 2011(Nov.)
Author:Haniu, Hisao; Matsuda, Yoshikazu; Usui, Yuki; Aoki, Kaoru; Shimizu, Masayuki; Ogihara, Nobuhide; Hara, Kazuo; Okamoto, Masanori; Takanashi, Seiji; Ishigaki, Norio; Nakamura, Koichi; Kato, Hiroyuki; Saito, Naoto


Cellular cytotoxic response induced by highly purified multi-wall carbon nanotube in human lung cells
Molecular and Cellular Biochemistry,352(1-2):57-63 2011(Jun.)
Author:Tsukahara, Tamotsu; Haniu, Hisao


Nanoparticle-mediated intracellular lipid accumulation during C2C12 cell differentiation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,406(4):558-563 2011(Mar.)
Author:Tsukahara, Tamotsu; Haniu, Hisao


Evaluation of CNT toxicity in comparison to tattoo ink nanoparticles for use as a biomaterial.
Mater Today.,14:434-440 2011
Author:Hara K, Kaoru Aoki K, Usui Y, Shimizu M, Narita N, Ogihara N, Nakamura K, Ishigaki N, Sano K, Haniu H, Kato H, Nishimura N, Kim YA, Taruta S, Saito N.


The Application of Proteomics to PK-PD Modeling and Simulation.
J Bioequiv Availab,2011:S2-002 2011
Author:Sako K, Haniu H, Hasegawa M, et al


Application of carbon fibers to biomaterials: A new era of nano-level control of carbon fibers after 30-years of development
CHEMICAL SOCIETY REVIEWS,40(7):3824-3834 2011
Author:Saito, Naoto; Aoki, Kaoru; Usui, Yuki; Shimizu, Masayuki; Hara, Kazuo; Narita, Nobuyo; Ogihara, Nobuhide; Nakamura, Koichi; Ishigaki, Norio; Kato, Hiroyuki; Haniu, Hisao; Taruta, Seiichi; Kim, Yoong Ahm; Endo, Morinobu


Proteomics-based safety evaluation of multi-walled carbon nanotubes
Toxicology and Applied Pharmacology,242(3):256-262 2010(Feb.)
Author:Haniu, H; Matsuda, Y; Takeuchi, K; Kim, YA; Hayashi, T; Endo, M


Effect of Lecithin: Cholesterol Acyltransferase on the Formation of Cross-linked Apolipoprotein AI.
J Ana Bio-Sci,33:151-160 2010
Author:Kurosaki Y, Ikeya H, Haniu H, et al


Potential of a Novel Safety Evaluation of Nanomaterials Using a Proteomic Approach
Journal of health science,55(3):428-434 2009(Jun.)
Author:Haniu,Hisao; Matsuda,Yoshikazu; Takeuchi,Kenji


Proteome Profiling of Vitreoretinal Diseases by Cluster Analysis.
Proteomics Clin Appl,2:1265-1280 2008
Author:Shitama, T; Hayashi, H; Noge, S; Uchio, E; Oshima, K; Haniu, H;Takemori, N; Komori, N; Matsumoto, H


Identification of 4-hydroxynonenal-modified retinal proteins induced by photooxidative stress prior to retinal degeneration.
Free Radic Biol Med,41:1847-1859 2006
Author:Tanito, M; Haniu, H; Elliott,MH; Singh, AK; Matsumoto, H; Anderson, RE


Role of systemic T-cells and histopathological aspects after subcutaneous implantation of various carbon nanotubes in mice
CARBON,44(6):1079-1092 2006
Author:Koyama, S; Endo, M; Kim, YA; Hayashi, T; Yanagisawa, T; Osaka, K; Koyama, H; Haniu, H; Kuroiwa, N


Proteomic trajectory mapping of biological transformation: Application to developmental mouse retina
PROTEOMICS,6(11):3251-3261 2006
Author:Haniu, H; Komori, N; Takemori, N; Singh, A; Ash, JD; Matsumoto, H


Medical application of carbon-nanotube-fitted nanocomposites: The microcatheter
SMALL,2(12):1406-1411 2006
Author:Koyama, S; Haniu, H; Osaka, K; Koyama, H; Kuroiwa, N; Endo, M; Kim, YA; Hayashi, T


Developmental proteomics of mouse retina.
INVESTIGATIVE OPHTHALMOLOGY&VISUAL SCIENCE,45:U318-U318 2004
Author:Haniu, H; Singh, A; Komori, N; Ash, JD; Koyama, S; Matsumoto, H


Different tissue reactions to activated carbon fivers - Pathological and immunological findings after subcutaneous implantation
Mol Cryst Liq Cryst,388:109-115 2002
Author:Koyama S, Tanaka S, Yamaguchi Y, Haniu H, Konishi G, Koyama H


Inhibition of cell cycle and induction of apoptosis due to modified C60 on HL-60 promyelocytic leukemic cells and it's macrophage-like cells
Mol Cryst Liq Cryst,386:21-24 2002
Author:Koyama S, Haniu H, Tanaka S, Yamaguchi Y, Konishi G, Koyama H


Cell growing with activated carbon fivers - Significances of porous size
Mol Cryst Liq Cryst,388:173-176 2002
Author:Koyama S, Haniu H, Takeichi T, Tanaka S, Yamaguchi Y, Konishi G, Koyama H


Effect of ONO-5046, a specific neutrophil elastase inhibitor, on the phorbol myristate acetate-induced injury in isolated dog lung
EXPERIMENTAL LUNG RESEARCH,25(1):55-67 1999
Author:Wang, HG; Shibamoto, T; Miyahara, T; Haniu, H; Tanaka, S; Fujimoto, K; Honda, T; Kubo, K; Koyama, S


In vitro and in vivo antiturnor activity of Yoshixol(TR) against murine L1210 leukemic cells
GENERAL PHARMACOLOGY,33(2):179-186 1999
Author:Tanaka, S; Koyama, S; Haniu, H; Yamaguchi, Y; Motoyoshiya, J


Yoshixol(TR) inhibits B16 melanoma cell growth in vivo and induces apoptosis-like (quantum thermodynamic) cell death
GENERAL PHARMACOLOGY,33(2):161-172 1999
Author:Koyama, S; Tanaka, S; Haniu, H; Yamaguchi, Y; Motoyoshiya, J


Presinusoidal vessels predominantly contract in response to norepinephrine, histamine, and KC1 in rabbit Liver
JOURNAL OF APPLIED PHYSIOLOGY,87(4):1404-1412 1999
Author:Shibamoto, T; Wang, HG; Miyahara, T; Tanaka, S; Haniu, H; Koyama, S

Themes for Joint Research
Development of novel safety evaluation of nanomaterials using proteomics , Toxicology
Development of novel quality control of nanomaterials using proteomics , Toxicology