Doctor of Health Science, 東京大学

Parasitology

感染免疫学

1998, The University of Tokyo, Graduate School, Division of Medicine

1995, The University of Tokyo, Graduate School, Division of Medicine

1993, The University of Tokyo, Faculty of Medicine

Endogenous IFN-gamma facilitates Pneumocystis infection and downregulates carbohydrate receptors in CD4+ T cell-depleted mice
Yi Wang; Hisashi Nagase; Yoh-ichi Tagawa; Shinsuke Taki; Masaya Takamoto; ( Y. Wang and H. Nagase equally contributed to this work.)
FEBS Letters, 598(13), 1633-1643, Jun. 2024, Refereed
Lead

State-of-the-Art Cancer Immunotherapies.
Hisashi Nagase; Takuma Kato; Takayuki Yoshimoto
International journal of molecular sciences, 25(5), Feb. 2024, Refereed
Lead

Genetic deficiencies of both IL-4 receptor alpha chain and IL-10 trigger early onset of severe colitis in mice.
Hisashi Nagase; Masaya Takamoto; Nancy Noben-Trauth
Cellular immunology, 393-394, 104779-104779, 2023, Refereed
Lead, Corresponding

Present and Future Therapies in Alzheimer's Disease
Hisashi Nagase, Kohzo Nakayama
Immunoregulatory Aspects of Immunotherapy, 177-197, 2018
Lead, Corresponding

Potential Therapeutic Targets and gamma-Secretase-Regulated APP Signaling in Alzheimer’s Disease
Hisashi Nagase; Kohzo Nakayama
Anals of Neurodegenerative Disorders, 2016
Lead

The Intracellular Domain of Amyloid Precursor Protein is a Potential Therapeutic Target in Alzheimer's Disease.
Hisashi Nagase; Kohzo Nakayama
Current drug discovery technologies, 11(4), 243-58, 2014
Lead

γ-Secretase-regulated signaling typified by Notch signaling in the immune system.
Hisashi Nagase; Kohzo Nakayama
Current stem cell research & therapy, 8(5), 341-56, Sep. 2013
Lead

γ-Secretase-regulated signaling: Notch, APP and Alzheimer's disease.
Nakayama K, Nagase H, Koh CS, Ohkawara T.
Current Psychopharmacology, 1, 155-166, 2012

γ-Secretase-regulated mechanisms similar to notch signaling may play a role in signaling events, including APP signaling, which leads to Alzheimer's disease.
Kohzo Nakayama; Hisashi Nagase; Chang-Sung Koh; Takeshi Ohkawara
Cellular and molecular neurobiology, 31(6), 887-900, Aug. 2011
Lead

γ-Secretase-regulated signaling pathways, such as notch signaling, mediate the differentiation of hematopoietic stem cells, development of the immune system, and peripheral immune responses.
Hisashi Nagase; Chang-Sung Koh; Kohzo Nakayama
Current stem cell research & therapy, 6(2), 131-41, Jun. 2011
Lead

The amyloid precursor protein intracellular domain alters gene expression and induces neuron-specific apoptosis.
Takeshi Ohkawara; Hisashi Nagase; Chang-Sung Koh; Kohzo Nakayama
Gene, 475(1), 1-9, Apr. 2011, Refereed
Lead

Do similar mechanisms regulated by γ-secretase play a potential role in signaling events involving type 1 transmembrane proteins including Notch, Delta andAPP?
Nakayama K, Nagase H, Hiratochi M, Koh CS, Ohkawara T.
Research Advances in Nucleic Acids Research, 3, 55, 2009

Similar mechanisms regulated by gamma-secretase are involved in both directions of the bi-directional Notch-Delta signaling pathway as well as play a potential role in signaling events involving type 1 transmembrane proteins.
Kohzo Nakayama; Hisashi Nagase; Masahiro Hiratochi; Chang-Sung Koh; Takeshi Ohkawara
Current stem cell research & therapy, 3(4), 288-302, Dec. 2008
Lead

The intracellular domain of amyloid precursor protein induces neuron-specific apoptosis.
Kohzo Nakayama; Takeshi Ohkawara; Masahiro Hiratochi; Chang-Sung Koh; Hisashi Nagase
Neuroscience letters, 444(2), 127-31, Oct. 2008, Refereed
Last

Despite increased CD4+Foxp3+ cells within the infection site, BALB/c IL-4 receptor-deficient mice reveal CD4+Foxp3-negative T cells as a source of IL-10 in Leishmania major susceptibility.
Hisashi Nagase; Kathryn M Jones; Charles F Anderson; Nancy Noben-Trauth
Journal of immunology (Baltimore, Md. : 1950), 179(4), 2435-44, Aug. 2007, Refereed
Lead

The Delta intracellular domain mediates TGF-beta/Activin signaling through binding to Smads and has an important bi-directional function in the Notch-Delta signaling pathway.
Masahiro Hiratochi; Hisashi Nagase; Yu Kuramochi; Chang-Sung Koh; Takeshi Ohkawara; Kohzo Nakayama
Nucleic acids research, 35(3), 912-22, 2007, Refereed
Lead

The relative contribution of IL-4 receptor signaling and IL-10 to susceptibility to Leishmania major.
Nancy Noben-Trauth; Rosalia Lira; Hisashi Nagase; William E Paul; David L Sacks
Journal of immunology (Baltimore, Md. : 1950), 170(10), 5152-8, May 2003, Refereed
Lead

Significant role of Fas ligand-binding but defective Fas receptor (CD95) in lymph node hyperplasia composed of abnormal double-negative T cells.
Akio Matsuzawa; Motomu Shimizu; Yasutaka Takeda; Hisashi Nagase; Kazutoshi Sayama; Mikio Kimura
Immunology, 106(4), 470-5, Aug. 2002, Refereed
Lead

Human bronchial epithelium expresses interleukin-9 receptors and releases neutrophil chemotactic factor.
Akihiro Tsukadaira; Yoshio Okubo; Sekiya Koyama; Etsuro Sato; Hisashi Nagase; Kazunaga Agematsu; Koh Nakazawa
Experimental lung research, 28(2), 123-39, Mar. 2002, Refereed
Lead

The different process of class switching and somatic hypermutation; a novel analysis by CD27(-) naive B cells.
Haruo Nagumo; Kazunaga Agematsu; Norimoto Kobayashi; Koji Shinozaki; Sho Hokibara; Hisashi Nagase; Masaya Takamoto; Kozo Yasui; Kazuo Sugane; Atsushi Komiyama
Blood, 99(2), 567-75, Jan. 2002, Refereed
Lead

Characterization of mouse mammary tumour virus-induced migration of lymphoid cells into lymph nodes.
A Matsuzawa; T Yasuda; S Sakamoto; H Nagase; H Nakano; T Yoshimoto
Scandinavian journal of immunology, 53(6), 553-62, Jun. 2001
Lead

Mechanism of hypergammaglobulinemia by HIV infection: Circulating memory B-cell reduction with plasmacytosis
Hisashi Nagase; Kazunaga Agematsu; Kiyoshi Kitano; Masaya Takamoto; Yoshio Okubo; Atsushi Komiyama; Kazuo Sugane
Clinical Immunology, 100(2), 250-259, 2001
Lead

Mechanism of hypergammaglobulinemia by HIV infection: Circulating memory B-cell reduction with plasmacytosis
Nagase, H; Agematsu, K; Kitano, K; Takamoto, M; Okubo, Y; Komiyama, A; Sugane, K
Clinical Immunology, 100(2), 250-259, 2001

A pivotal role of cell-bound but not soluble CD4 molecules in full development of lupus-like manifestations in MRL-Fas(lprcg)/Fas(lprcg) mice.
Y Zhang; T Yasuda; C R Wang; T Yoshimoto; H Nagase; M Takamoto; A Tsubura; M Kimura; A Matsuzawa
Clinical and experimental immunology, 122(1), 124-32, Oct. 2000
Lead

Impaired delayed-type hypersensitivity response in mutant mice secreting soluble CD4 without expression of membrane-bound CD4.
C R Wang; A Hino; T Yoshimoto; H Nagase; T Kato; K Hirokawa; A Matsuzawa; H Nariuchi
Immunology, 100(3), 309-16, Jul. 2000, Refereed
Lead

Immunological characterization of C3H mice congenic for Fas(lprcg), C3h/HeJ-Fas(lprcg)/Fas(lprcg).
T Yasuda; Y Zhang; H Nagase; T Kaneko; K Sayama; H Hashimoto; A Matsuzawa
Laboratory animals, 34(1), 46-55, Jan. 2000
Lead

Alleviation of renal disease and lymphadenopathy in MRL-Fasp(lrcg)/Fas(lprcg) (MR-lpr(cg)) mice neonatally infected with mouse mammary tumor virus encoding superantigen strongly reactive with TCR Vbeta8.2 element.
A Matsuzawa; T Yasuda; Y Zhang; H Nagase; T Yoshimoto; M Kimura; A Tsubura
Viral immunology, 13(3), 297-311, 2000
Lead

Interleukin-12 expression in B cells by transformation with Epstein-Barr virus.
T Yoshimoto; H Nagase; T Yoneto; J i Inoue; H Nariuchi
Biochemical and biophysical research communications, 252(3), 556-60, Nov. 1998, Refereed
Lead

Novel mutant mice secreting soluble CD4 without expression of membrane-bound CD4.
H Nagase; C R Wang; T Yoshimoto; C Sugishita; T Shiroishi; A Matsuzawa; H Nariuchi
European journal of immunology, 28(2), 403-12, Feb. 1998, Refereed
Lead

Functional analysis of T cells from mutant mice deleted of transmembrane portion of CD4 (III)
Chrong-Reen Wang; Takayuki Yoshimoto; Hideo Nariuchi; Hisashi Nagase; Akio Matsuzawa
Japanese Journal of Clinical Immunology, 21, 343-352, 1998
Lead

Induction of interleukin-12 p40 transcript by CD40 ligation via activation of nuclear factor-kappaB.
T Yoshimoto; H Nagase; T Ishida; J Inoue; H Nariuchi
European journal of immunology, 27(12), 3461-70, Dec. 1997, Refereed
Lead

Deletion of CD4+ T cells by mouse mammary tumor virus (FM) superantigen with broad specificity of T cell receptor beta-chain variable region.
T Yoshimoto; H Nagase; H Nakano; A Matsuzawa; H Nariuchi
Virology, 223(2), 387-91, Sep. 1996, Refereed
Lead

Early activation signal transduction pathways of Th1 and Th2 cell clones stimulated with anti-CD3. Roles of protein tyrosine kinases in the signal for IL-2 and IL-4 production.
T Tamura; H Nakano; H Nagase; T Morokata; O Igarashi; Y Oshimi; S Miyazaki; H Nariuchi
Journal of immunology (Baltimore, Md. : 1950), 155(10), 4692-701, Nov. 1995, Refereed
Lead

A V beta 8.2-specific superantigen from exogenous mouse mammary tumor virus carried by FM mice.
T Yoshimoto; H Nagase; H Nakano; A Matsuzawa; H Nariuchi
European journal of immunology, 24(7), 1612-9, Jul. 1994, Refereed
Lead

Present and Future Therapies for Alzheimer's Disease
Hisashi Nagase; Kohzo Nakayama, Joint work, Immunoregulatory Aspects of Immunotherapy, Chapter 8
InTechOpen, 2018

Amyloid Precursor Protein: Its signaling aspect and Alzheimer's disease
Kohzo Nakayama; Hisashi Nagase; Chang-Sung Koh; Takeshi Ohkawara, Joint work, Amyloids: Composition, Functions and Pathology, Chapter 2
Nova Science Publishers, Inc., 2012

Intech Publishers, Inc.
Nakayama K, Nagase H, Koh CS, Ohkawara T., γ-Secretase-regulated signaling mechanisms: Notch and amyloid precursor protein.
Intech Publishers, Inc., 2011

Generation of novel inflammatory disease model caused by dysregulation of IL-1 signaling
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
The University of Tokyo
01 Apr. 2012 - 31 Mar. 2015

The contribution of Delta signaling regulated by γ-secretase on the differentiation of peripheral CD4 T cells
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B)
Shinshu University
2010 - 2012

寄生蠕虫プロテアーゼのTh2分化における役割に関する研究
科学研究費助成事業, 日本学術振興会, 奨励研究(A)
信州大学
1999 - 2000

寄生虫感染時のTH2分化のメカニズムの解析