Doctor of Agriculture, Tohoku University

Bioorganic chemistry, Bioorganic chemistry

2014
信州大学先鋭領域融合研究群　バイオメディカル研究所　協力教員

2014
信州大学学術研究院農学系　教授

1997, Tohoku University, Graduate School, Division of Agriculture, 農芸化学専攻

1992, Tohoku University, Faculty of Agriculture, 農芸化学科

2013 - 2015
特別研究員審査会専門委員会書面審査員, 日本学術振興会

2011 - 2012
特別研究員審査会専門委員会書面審査員, 日本学術振興会

First total synthesis of Inaoside A
Takao, T.; Kawamura, A.*; Makabe, H.*
Asian J. Org. Chem., in press., Dec. 2024, Refereed
Last

Synthesis of prodelphinidin B2 3,3”-digallate using AgOTf mediated self-condensation
Saito, H.; Takahashi, Y.; Kawamura, A.*; Makabe, H.*
Results in Chemistry, 12, 101902, Dec. 2024, Refereed
Last, Corresponding

Inaoside A: new antioxidant phenolic compound from the edible mushroom Laetiporus cremeiporus
Kawamura, A.*; Mizuno, A.; Kurakake, M.; Yamada, A., Makabe, H.*
Heliyon, 10, e24651, Jan. 2024, Refereed
Corresponding

Application of Pd-catalyzed carbonylation followed by spontaneous oxa-Michael addition/diastereoselective reduction of ynone: Synthesis of (+)-goniofufurone
Kameyama, Y.; Makabe, H.*
Tetrahedron Lett., 132, 154827, Nov. 2023, Refereed
Corresponding

Oral administration of procyanidin B2 3,3"-di-O-1 gallate ameliorates experimental autoimmune encephalomyelitis through immunosuppressive effects on CD4+ T cells by regulating glycolysis
Endo, K.; Sawa, T.; Tanaka, Y.; Saiki, T.; Haga, H.; Rizeq, L.; Aso, H.; Isono, M.; Niitsuma, F.; Masaki, A.; Makabe, H.; Tanaka, S.*
Eur. J. Pharm., 954, 175879, Jul. 2023, Refereed

Procyanidin B2 3,3′′-di-O-gallate ameliorates imiquimod-1 induced psoriasis by suppressing TLR7 signaling through the inhibition of endosomal acidification in dendritic cells
Sawa, T.; Endo K.; Nakashima, A.; Tanaka, Y.; Makabe, H.; Tanaka, S.*
International Immunopharmacology, 121, 110444, Jun. 2023, Refereed

Procyanidin B2 3,3″-di-O-gallate suppresses IFN-γ production in CD4+ T cells through the regulation of glutamine influx via direct interaction with ASCT2
Endo, K.; Sawa, T.; Kitamura, H.; Makabe, H.; Tanaka, S.*
International Immunopharmacology, 115, 109617, Dec. 2022, Refereed

Intestinal permeability of agaro-oligosaccharides: Transport across Caco-2 cell monolayers and pharmacokinetics in rats
Shirai, I.; Karasawa, K.; Kodaira, Y.; Iwasaki, Y.; Shigemura, Y.; Makabe, H.; Katayama, S.*
Frontiers in Nutrition, 9, 996607, Aug. 2022, Refereed

Concise Synthesis of Procyanidin B2 3,3”-digallate Using Yb(OTf)3 Mediated Self-Condensation
Tanaka,Y.; Kobayashi, S.; Hattori, Y.; Kawamura, A.; Makabe, H.*
Synlett, 33, 1071-1074, 2022, Refereed
Last, Corresponding

Synthesis of (+)-Muconin via Diastereoselective Oxypalladation
Sugimoto, M.; Nosho, S.; Hikosaka, G.; Hattori, Y.; Umezawa, K.; Kawamura, A.; Makabe, H.*
J. Org. Chem., 86, 4859-4866., Mar. 2021, Refereed

The suppression of IL-17 production from T cells by gallate-type procyanidin is mediated by selectively inhibiting cytokine production from dendritic cells
Endo, K.; Sawa, T.; Matsui, R.; Asami, T.; Tanaka, Y.; Makabe, H.; Tanaka, S.*
Biomedicine & Pharmacotherapy, 137, 111346., Feb. 2021, Refereed

Synthesis of (+)-solenopsin via Pd-catalyzed N-Alkylation and Cyclization
Suzuki, K.; Hattori, Y.; Kawamura, A.; Makabe, H.*
Biosci. Biotecnol. Biochem., 85, 223-227., Feb. 2021, Refereed

Procyanidin B2 gallate regulates TNF-α production from T cells through inhibiting glycolytic activity via mTOR-HIF-1 pathway
Endo, K.; Matsui, R.; Sugiyama. M.; Asami, T.; Inaba, C.; Kobayashi, S.; Makabe, H.; Tanaka, S.*
Biochem. Pharm., 177, 113952, Jun. 2020, Refereed

Identification and characterization of oligomeric proanthocyanidins with significant anti-cancer activity in adzuki beans (Vigna angularis)
Kawahara, S.; Ishihara, C.; Matsumoto, K.; Senga, S.; Kawaguchi, K.; Yamamoto, A.; Suwannachot, J.; Hamauzu, Y.; Makabe, H.*; Fujii, H.*
Heliyon, 5, e02610, 24 Oct. 2019, Refereed

Synthesis of (+)-goniopypyrone and (+)-goniotriol using Pd-catalyzed carbonylation
Miyazawa, Y.; Oda-Tanaka, A.; Makabe, H.*
Tetrahedron Lett., 60, 151039, Sep. 2019, Refereed

Isolation and characterization of a novel oligomeric proanthocyanidin with significant anti-cancer activities from grape stems (Vitis vinifera)
Kawahara, S.; Toda, K.; Matsumoto, K.; Ishihara, C.; Nonobe, S.; Matsunaga, C.; Gomi, K. Y.; Senga, S.; Kawaguchi, K.; Yamamoto, A.; Suwannachot, J.; Noda, R.; Kobayashi, S.; Hamauzu, Y.; Makabe, H.*; Fujii, H.*
SCIENTIFIC REPORTS, 9, 12046-12053, Aug. 2019, Refereed

Adzuki bean (Vigna angularis) extract reduces amyloid-β aggregation and corrects cognitive impairment in Drosophila models of Alzheimer’s disease
Miyazaki, H.; Okamoto, Y.; Watanabe, T.; Katayama, S.; Kawahara, S.; Makabe, H.; Fujii, H.; Yonekura, S.*
NUTRITION RESEARCH AND PRACTICE, 13, 64-69, Feb. 2019, Refereed

Synthesis of (+)-altholactone, (+)-7-epi-altholactone, (-)-etharvensin, and (-)-almuheptolide-A using Pd-catalyzed carbonylation
Miyazawa, Y.; Hattori, Y.; Makabe, H.*
Tetrahedron Lett., 59, 4024-4027, Nov. 2018, Refereed

Synthesis of epigallocatechin trimer, (epigallocatechin)2-epicatechin, and (epigallocatechin)2-catechin via a Lewis acid mediated one-pot condensation and their antitumor activities in prostate cancer cells
Ichikawa,M.; Yamamoto,S.; Ishihara,C.; Nonobe, S.; Hattori, Y.; Umezawa, K.; Fujii, H*.;Makabe, H.*
Tetrahedron, 74, 3534-3542, Jul. 2018, Refereed

Kale supplementation up-regulates HSP70 and suppresses cognitivedecline in a mouse model of accelerated senescence
Kushimoto, S.; Uchibori, Y.; Yanai, S.; Suto, Y.; Kobayashi, H.; Makabe, H.; Nakamura, S.; Katayama, S.*
Journal of Functional Foods, 44, 292-298, May 2018, Refereed

An asymmetric synthesis of (+)-monomorine I
Asai, M.; Takemoto, Y.; Deguchi, A.; Hattori, Y.; Makabe, H.*
Tetrahedron: Asymmetry, 28, 1582-1586, Nov. 2017, Refereed

Epicatechin oligomers longer than trimers have anti-cancer activities, but not the catechin counterparts
Takanashi, K.; Suda, M.; Matsumoto, K.; Ishihara, C.; Toda, K,; Kawaguchi, K.; Senga, S.; Kobayashi, N.; Ichikawa, M.; Katoh, M.; Hattori, Y.; Kawahara, S. –i.; Umezawa, K.; Fujii, H*.; Makabe, H.*
SCIENTIFIC REPORTS, 7, 7791, 10 Aug. 2017, Refereed

Synthesis of Isocoumarin Compounds, 8-Hydroxy-6-methoxy-3-pentyl-1H-isochromen-1-one and Fusariumin Analog Using Palladium-catalyzed Carbonylation Trapping with O-Enolate
Asai, M.; Hattori, Y.; Makabe, H.*
Heterocycles, 94(8), 1542-1553, Aug. 2017, Refereed

Synthesis of (-)-isosolenopsin using Diasereoselective Aminopalladation
Takemoto, Y.; Hattori, Y.; Makabe, H*
Heterocycles, 94(2), 286-296, Feb. 2017, Refereed

Procyanidin B2 Gallates Inhibit IFN-γ and IL-17 Production in T cells by Suppressing T-bet and RORγt Expression
Tanaka, S.*; Furuya, K,;Yamamoto, K.; K. Yamada, K.; Ichikawa, M.; Suda, M.; Makabe, H.
International Immunopharmacology, 44, 87-96, Jan. 2017, Refereed

Synthesis of Prodelphinidin Trimer Isolated from Cistus albidus and Its Growth Inhibitory Activity Against Human Prostate Cancer Cell Lines
Mori, M.; Matsumoto, K.; Ishihara, C.; Kawaguchi, K.; Kawahara, S. -i.; Hattori, Y.; Fujii, H.;* Makabe, H.*
Heterocycles, 92(10), 1822-1831, Oct. 2016, Refereed

Synthesis of legioliulin, a fluorescent isocoumarin compound, isolated from Legionella dumoffii using cyclic acylpalladation and Heck reaction
Asai, M.; Hattori, Y.; Makabe, H*
Tetrahedron Lett., 57, 3942-3944., Aug. 2016, Refereed

Concise Synthesis of Cinnamtannin A2 from Dimeric Epicatechin Electrophile and Nucleophile Prepared by Zn(OTf)2 Mediated Self-Condensation
Ichikawa, M.; Takanashi, K.; Suda, M.; Hattori, Y.; Kawahara, S.-i.; Fujii, H.; Makabe, H*.
Synthesis, 48, 1525-1532, May 2016, Refereed

Synthesis of Decytospolide A, B and Their C-3-epimers Using Stereoselective Oxypalladation
Kurogome, Y.; Hattori, Y.; Makabe, H.*
Synthesis, 48, 765-771, Mar. 2016, Refereed

Synthesis of Arecatannin A from Dimeric Epicatechin Electrophile
Suda, M.; Takanashi, K.; Katoh, M.; Matsumoto, K.; Kawaguchi, K.; Kawahara, S. -i.; Fujii, H.; Makabe, H.*
Nat. Prod. Commun., 10(6), 959-962, Jun. 2015, Refereed

Divergent Synthesis of 2,6-Disubstituted Piperidine Alkaroid, (+)-Spectaline by Palladium-Catalyzed Cyclization
Katsuyama, M.; Furuta, M.;Kobayashi, K.; Teruya, K.; Makabe, H.; Akaji, K.; Hattori, Y.*
Heterocycles, 91(5), 959-969, May 2015, Refereed

Syntheses of a pyrrolidine analog of a tetrahydrofuran containing acetogenin, cis-solamin
Onishi, K.; Sakurai, H.; Kobayashi, K.; Makabe, H.; Teruya, K.; Akaji, K.; Hattori, Y.*
Heterocycles, 91(3), 573-582, Mar. 2015, Refereed

Selective Synthesis of Epicatechin Dimers Using Zn(OTf)2 Mediated Self- Condensation
Suda, M.; Fujii, W.; Takanashi, K.; Hattori, Y.; Makabe, H.*
Synthesis, 46(24), 3351-3355, 15 Dec. 2014

Synthesis of both enantiomer of akolactone B and (+)-ancepsenolide
Hikosaka,G.; Hattori,Y.;Makabe, H*
Tetrahedron: Asymmetry, 25(20-21), 1367-1371, 31 Oct. 2014

Synthesis of four diastereomers and structural revision of tetradenolide
Tokuda, M.; Kurogome, Y.; Katoh, R.; Nohara, Y.; Hattori, Y.; Makabe, H.*
Tetrahedron Lett., 55(30), 4189-4192, 23 Jul. 2014, Refereed

Synthesis of (+)-boronolide and (+)-deacetylboronolide using Pd-catalyzed carbonylation and lactonization
Kurogome, Y.; Hattori, Y.; Makabe, H*
Tetrahedron Lett., 55(17), 2822-2824, 23 Apr. 2014

Syntheses of prodelphinidin B1, B2 and B4 and their antitumor activities against human PC-3 prostate cancer cell lines
Fujii, W.; Toda, K.; Matsumoto, K.; Kawaguchi, K.; Kawahara, S. -i.; Hattori, Y.; Fujii, H.*; Makabe, H.*
Tetrahedron Lett., 54(52), 7188-7192, 25 Dec. 2013, Refereed

Recent Syntheses of Proanthocyanidin
Makabe, H.*
Heterocycles, 87(11), 2225-2248, 01 Nov. 2013, Refereed, Invited

Total synthesis of (+)-azimine via diastereoselective aminopalladation
Kurogome, Y.; Kogiso, M.; Looi, K. K.; Hattori, Y.; Konno, H.; Hirota, M.; Makabe, H.*
Tetrahedron, 69(39), 8349-8352, 30 Sep. 2013, Refereed

Syntheses of procyanidin B2and B3 gallatederivatives using equimolar condensation mediated by Yb(OTf)3 and their antitumor activities
Suda, M.; Katoh, M.; Toda, K.; Matsumoto, K.; Kawaguchi, K.; Kawahara, S-i.; Hattori, Y.; Fujii, H.*; Makabe, H.*
Bioorg. Med. Chem. Lett., 23(17), 4935-4939, 01 Sep. 2013

Stereoselective Aminopalladation and Oxypalladation and Their Application to the Synthesis of Natural Products
Makabe, H.
Nat. Prod. Commun., 8(7), 1005-1010, Jul. 2013, Refereed

Syntheses of prodelphinidin B3 and C2, and their antitumor activities through cell cycle arrest and caspase-3 activation
Fujii, W.; Toda, K.; Kawaguchi, K.; Kawahara, S-i.; Katoh, M.; Hattori, Y.; Fujii,H.*; Makabe, H.*
Tetrahedron, 69(17), 3543-3550, 18 Apr. 2013, Refereed

“Enzymatic synthesis of novel phenol acid rutinosides using rutinase and their antiviral activity in vitro”
Katayama, S.; Ohno, F.; Yamauchi,Y.; Kato, M.; Makabe, H.; Nakamura, S.*
J. Agric. Food Chem., 61, 9617-9622, 2013, Refereed

Synthesis of Procyanidin C2 and C1 Using Lewis Acid Mediated Equimolar Condensation
Oizumi, Y.; Katoh, M.; Hattori, Y.; Toda, K.; Kawaguchi, K.; Fujii, H.; Makabe, H.*
Heterocycles, 85(9), 2241-2250, Sep. 2012, Refereed

Synthesis of Procyanidin B1, B2, and B4 and Their Anti-inflammatory Activity
Katoh, M.; Oizumi, Y.; Mohri, Y.; Hirota, M.; Makabe, H.*
Lett. Org. Chem., 9(4), 233-238, 2012, Refereed

バイレンシ科アセトゲニン類の合成とミトコンドリアcomplexIに対する阻害活性
服部恭尚，今野博行，三芳秀人，真壁秀文*
有機合成化学協会誌, 69(2), 159-168, 2011, Refereed

Efficient Stereoselective Synthesis of Catechin Trimer Derivative Using Silver Lewis Acid Catalyzed Equimolar Condensation
Oizumi, Y.; Mohri, Y.; Hattori, Y.; Makabe,H.*
Heterocycles, 83(4), 739-742, 2011, Refereed

Synthesis of solamin type mono-THF acetogenins using cross-metathesis
Konno, H*.; Makabe, H.; Hattori, Y.; Nosaka,K.; Akaji, K.
Tetrahedron, 66(40), 7946-7953, 2010, Refereed

Synthesis of Annonacin Isolated from Annona densicoma
Oasa, M., Hattori, Y., Konno, H., Makabe, H.*
Biosci. Biotechnol. Biochem., 74(6), 1274-1275, 2010, Refereed

Synthesis of Procyanidin B3 and Its Anti-inflammatory Activity. The Effect of 4-Alkoxy Group of Catechin Electrophile in the Yb(OTf)3 Catalyzed Condesation with Catechin Nucleophile
Oizumi, Y.; Mohri, Y.; Hirota, M.; Makabe,H.*
J. Org. Chem., 75(14), 4884-4886, 2010, Refereed

Heat treatment of Chinese quince polyphenols increases rat plasma levels of protocatechine and vanilic acids
Hamauzu, Y.*; Takedachi, N.; Miyasaka, R.; Makabe, H.
Food Chem., 118(3), 757-763, 2010, Refereed

Asymmetric syntheses of daedalin A and quercinol and their tyrosinase inhibitory activity
Sekimoto, M.; Hattori, Y.; Morimura, K.; Hirota,M.; Makabe, H.*
Bioorg. Med.Chem.Lett., 20(3), 1063-1064, 2010, Refereed

Daedalin A, a Metabolite of Daedalia dickinsii, Inhibits Melanin Synthesis in an in vitro Human Skin Model
Morimura, K.,Hiramatsu, K.; Yamazaki, C., Hattori, Y., Makabe, H., Hirota, M.*
Biosci. Biotechnol. Biochem., 73(3), 627-632, 2009, Refereed

Synthesis of (-)-Epicatechin 3-(3"-O-Methylgallate) and (+)-Catechin 3-(3"-O-Methylgallate) and Their Anti-infalammatory Activity
Iijima, T.; Mohri, Y.; Hattori, Y.; Kashima, A.; Kamo, T.; Hirota, M.; Kiyota, H.; Makabe, H.*
Chem. Biodivers., 6(4), 520-526, 2009, Refereed

Short Step Synthesis of Resveratrol Derivative from Commercially Available 1,3-Dimethoxybenzene and 4-Vinylanisole
Iijima, T; Makabe, H.*
Biosci. Biotechnol. Biochem., 73(11), 2547-2548, 2009, Refereed

AnEfficient Synthesisof Procyanidins using Equimolar Condensation of Catechin and/or Epicatechin Catalyzed by Ytterbium Triflate
Mohri,Y.; Sagehashi, M.; Yamada, T.; Hattori, Y.; Morimura, K.; Hamauzu, Y.; Kamo, T.; Hirota, M.; Makabe, H.*
Heterocycles, 79(1), 549-563, 2009, Refereed

A Concise Synthesis of Solamin and cis-Solamin, Mono-THF Acetogenins from Annona muricata
Makabe, H.*; Kuwabara, A.; Hattori, Y.; Konno, H.
Heterocycles, 78(9), 2369-2376, 2009, Refereed

Current Topics of Organic and Biological Chemistry of Annonaceous Acetogenins and Their Synthetic Mimics
Makabe, H.*; Konno, H.; Miyoshi, H.*
Current Drug Discovery Technologies, 5(3), 213-229, 2008, Refereed

Total synthesis of cis-solamin A, a mono-tetrahydrofuran acetogenin isolated from Annona muricata
Konno, H.*; Okuno, Y.; Makabe, H.; Nosaka, K.; Onishi, A.; Abe, Y.; Sugimoto, A.; Akaji, K.
Tetrahedron Lett., 49, 782-785, 2008, Refereed

Stimulation conditions for spore germination of Agaricus blazei
Mahmud, M. A.; Ohno, S.; Fukuda, M.*; Yamada, A.; Hattori, Y.; Makabe, H.
Mushuroom Science and Biotechnology, 16(2), 87-92, 2008, Refereed

Synthesis of Pyranicin and Its Inhibitory Action with Bovine Heart Mitochondrial Complex I
Hattori, Y.; Furuhata, S.; Okajima, M.; Konno, H.; Abe, M.; Miyoshi, H.; Goto, T.; Makabe, H.*
Org. Lett., 10, 717-720, 2008, Refereed

DynamicFunction of the Spacer Region of Acetogenins in the Inhibition of Bovine Mitochondrial NADH-Ubiquinone Oxidoreductase (Complex I)
Abe, M.; Kubo, A.; Yamamoto, S.; Hatoh, Y.; Murai, M.; Hattori, Y.; Makabe, H.; Nishioka, T.; Miyoshi, H.*
Biochemistry, 47(23), 6257-6263, 2008, Refereed

Synthesis of pyranicin and its deoxygenated analogues and their inhibitory action with bovine heart mitochondrial complex I
Furuhata, S.;Hattori, Y.; Okajima, M.; Konno, H.; Abe, M.; Miyoshi, H.; Goto, T.; Makabe, H.*
Tetrahedron, 64, 7695-7703, 2008, Refereed

Taxpropellane: A Novel Taxane with an Unprecedented Polycyclic Skeleton from the Needles of Taxus canadensis
Zhang, M. L; Dong, M.; Huo, C. -H.; Li, L. -G.; Sauriol, F.; Shi, Q.-W.*; Gu,Y. -C.; Makabe, H.; Kiyota, H.
Eur. J. Org. Chem., 5414-5417, 2008, Refereed

Synthesis of Annonaceous Acetogenins from Muricatacin
Makabe, H.
Biosci. Biotechnol. Biochem., 71, 2367-2374, 2007

Synthesis, determination of the absolute configuration oftonkinelin, and inhibitoryaction with bovine heart mitochondrial complex I
Hattori, Y., Konno, H., Abe, M., Miyoshi, T. Goto, T., Makabe, H.*
Bioorg. Med. Chem., 15, 3026-3031, 2007

Total synthesis of miraziridine A and identification of its major reaction site for cathepsin B
Konno, H.*; Kubo, K.; Makabe, H.; Toshiro,E.; Hinoda, N.; Nosaka, K.; Akaji, K.
Tetrahedron, 63, 9502-9513, 2007

A refined method for determining the absolute configuration of the 3-hydroxy-3-methylglutaryl group
Hattori, Y., Horikawa, K., Makabe, H., Hirai, N., Hirota, M., Kamo, T.*
Tetrahedron: Asymmetry, 18, 1183-1186, 2007

An efficient synthesis of procyanidins. Rare earth metal Lewis acid catalyzed equimolar condensation of catechin and epicatechin
Mohri, Y., Sagehashi, M., Yamada, T., Hattori, Y., Morimura, K., Kamo, T., Hirota, M., Makabe, H.*
TetrahedronLett., 48, 5891-5894, 2007

A Tyrosinase Inhibitor, Daedalin A, from the Mycelial Culture of Daedalea dickinsi
Morimura, K., Yamazaki, C., Hattori, Y., Makabe, H., Kamo, T., Hirota,M.*
Biosci. Biotechnol. Biochem., 71, 2837-2840, 2007

Repraesentins D, E and F, New Plant Growth Promoters from Lactarius repraesentaneus
Kashiwabara, M.; Kamo, T.*; Makabe, H.; Shibata, H.; Hirota, M.
Biosci. Biotechnol. Biochem., 70(6), 1502-1505, 2006

Synthesis of murisolin, (15R, 16R, 19R, 20S)-murisolin A, and (15R, 16R, 19S, 20S)-16,19-cis-murisolin and their inhibitory action with bovine heart mitochondrial complex I
Hattori,Y; Kimura, Y; Moroda, A; Konno, H; Abe, M; Miyoshi, H; Goto, T; Makabe, H.*
CHEMISTRY-AN ASIAN JOURNAL, 1(6), 894-904, 2006

Anti-inflammatory sesquiterpenes from Curcuma zedoaria
Makabe, H.*; Maru, N; Kuwabara, A; Kamo, T; Hirota, M
NATURAL PRODUCT RESEARCH, 20(7), 680-685, 2006

Synthesis of (4R,15R,16R,21S)- and (4R,15S,16S,21S)-rollicosin, squamostolide, and their inhibitory action with bovine heart mitochondrial complex I
Makabe, H.*; Kimura, Y; Higuchi, M; Konno, H; Murai, M;Miyoshi, H
BIOORGANIC&MEDICINAL CHEMISTRY, 14(9), 3119-3130, 2006

Dynamic function of the alkyl spacer of acetogenins in their inhibitory action with mitochondrial complex I (NADH-ubiquinone oxidoreductase)
Abe, M; Murai, M; Ichimaru,N; Kenmochi, A; Yoshida, T; Kubo, A; Kimura, Y; Moroda, A;Makabe, H; Nishioka, T; Miyoshi,H.*
Biochemistry, 44(45), 14898-14906, 2005

Synthesisof(4R,15R,16R,21S)- and (4R,15S,16S,21S)-rollicosin
Makabe, H.*; Higuchi, M; Konno, H; Murai, M; Miyoshi, H
Tetrahedron Letters, 46(27), 4671-4675, 2005

Synthesis and inhibition mechanism ofDelta lac-acetogenins, a novel type of inhibitor of bovine heart mitochondrial complex I
Ichimaru, N; Murai, M; Abe, M; Hamada, T; Yamada, Y; Makino, S; Nishioka, T; Makabe, H; Makino, A; Kobayashi, T; Miyoshi, H.*
Biochemistry, 44(2), 816-825, 2005

Synthesis of two possible diastereomers of reticulatain-1
Makabe, H.*; Miyawaki, A.; Takahashi, R.; Hattori, Y.; Konno, H.; Abe, M.; Miyoshi, H.
Tetrahedron Lett., 45(5), 973-977, Jan. 2004

Synthesis and mitochondrial complex I inhibition of dihydroxy-cohibin A, non-THF annonaceous acetogenin analogue
Konno, H.*; Hiura, N.; Makabe, H.; Abe, M.; Miyoshi, H.
Bioorg. Med. Chem. Lett., 14(3), 629-632, Jan. 2004

Total synthesis of cis-solamin and its inhibitory action with bovine heart mitochondrial complex I
Makabe, H.*; Hattori, Y; Kimura, Y; Konno, H; Abe, M; Miyoshi, H; Tanaka,A;Oritani, T
Tetrahedron, 60(47), 10651-10657, 2004

Anti-inflammatory cyathane diterpenoids from Sarcodon scabrosus
Kamo, T.*; Imura, Y; Hagio, T; Makabe, H; Shibata, H; Hirota, M
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 68(6), 1362-1365, 2004

Efficient Synthesis of Akolactone A via Pd-Catalyzed Carbonylation
Makabe, H.*; Okajima, M.; Konno, H.; Kamo, T.; Hirota, M.
Biosci. Biotechnol. Biochem., 67(12), 2658-2660, Dec. 2003

Total Synthesis of (-)-Cassine
Makabe, H.*; Kong, L. K.; Hirota, M.
Org. Lett., 5(1), 27-29, Jan. 2003

Myrsinoic acid E, an anti-inflammatory compound from Myrsine seguinii
Makabe, H.* Miyazaki, S; Kamo, T; Hirota, M
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 67(9), 2038-2041, 2003

New plant growth promoters, repraesentins A, B and C, from Lactarius repraesentaneus
Hirota, M.*; Shimizu, Y; Kamo, T;Makabe, H; Shibata, H.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 67(7), 1597-1600, 2003

Structural revision of epoxyrollins A and B, biosynthetic precursors of annonaceous acetogenins
Konno, H.*; Makabe, H
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 67(6), 1438-1441, 2003

Total Synthesis of cis-Solamin
Makabe, H.*; Hattori, Y.; Tanaka, A.; Oritani, T.
Org. Lett., 4(7), 1083-1085, Apr. 2002

バイレンシ科アセトゲニン類の合成研究
信州大学農学部紀要, 37(2), 93-99, Mar. 2001

A Novel Hydrogen Transfer Hydroalumination of Alkenes withTriisobutylaluminum Catalyzed by Pd and Other Late Transition Metal Complexes
Gagneur, S.; Makabe, H.; Negishi, E.*
Tetrahedron Lett., 42(2), 785-787, Jan. 2001

Intermolecular trapping of acylpalladium and related acylmetal derivatives with active C-H compounds
Negishi, E.*; Liou, S. -Y.; Xu, C.; Shimoyama, I.; Makabe, H.
J. Mol. Cat. (A), 143, 279-286, Jan. 1999

Hydrogen Transfer Hydrozirconation of Alkenes with i-BuZrCp2Cl Catalyzed by Lewis-Acidic Metal Compounds Containing Al, Zn, Si, Ag, and Pd
Makabe, H.; Negishi, E.*
Eur. J. Org. Chem., 969-971, 1999

Catalytic Generation and Trapping Acylmetals Containing Ni and Cu with Enolates
Negishi, E.*; Makabe, H.; Shimoyama, I.; Wu, G.; Zhang, Y.
Tetrahedron, 54(2), 1095-1106, Jan. 1998

Total Synthesis of (+)-4-Deoxygigantecin
Makabe, H.; Tanaka, A.*; Oritani, T.
Tetrahedron, 54, 6329-6340, 1998

Total Synthesis of (+)-4-Deoxygigantecin
Makabe, H.; Tanaka, A.*; Oritani, T.
Tetrahedron Lett., 38(24), 4247-4250, Jun. 1997

Total Synthesis of (8’R)-,and (8’S)-Corrosoline
Makabe, H.; Tanimoto, H.; Tanaka, A.*; Oritani, T.
Heterocycles, 43(10), 2229-2248, Oct. 1996

Total Synthesis of (15S, 16R, 19S, 20R, 34S)-Diepomuricanin
Konno, H.; Makabe, H.; Tanaka, A.*; Oritani, T.
Tetrahedron Lett., 37(30), 5393-5396, Aug. 1996

Synthesis of Two Possible Diastereoisomers of the Epoxy Lactone Proposed for an Annonaceous Acetogenins, Epoxyrollin A
Konno, H.; Makabe, H.; Tanaka, A.*; Oritani, T.
Tetrahedron, 52(28), 9399-9408, Jul. 1996

Syntehsis of Squamostanal-A
Konno, H.; Makabe, H.; Tanaka, A.*; Oritani, T.
Biosci. Biotechnol. Biochem., 60(3), 526-527, Mar. 1996

Synthesis of Two Possible Diastereoisomers of the Epoxy Lactone Proposed for Epoxyrollin A
Konno, H.; Makabe, H.; Tanaka, A.*; Oritani, T.
Biosci. Biotechnol. Biochem., 59(12), 2355-2357, Dec. 1995

Total Synthesis of Solamin and Reticulatacin
Makabe, H.; Tanaka, A.*; Oritani, T.
J. Chem. Soc. Perkin Trans. 1, 1975-1981, 1994

Synthesis of (-)-Muricatacin
Makabe, H.; Tanaka, A.*; Oritani, T.
Biosci. Biotechnol. Biochem., 57(6), 1028-1029, Jun. 1993

ヒアリの毒性成分とその作用
真壁秀文
化学と生物, 56(7), 513-515, Jul. 2018, Refereed

プロアントシアニジンオリゴマーの生物活性
真壁秀文，河原誠一，藤井博
化学と生物, 54(9), Sep. 2016, Refereed

Winners of CASMI2013: Automated Tools and Challenge Data
Nishioka, T.*; Kasama, T.; Kinumi, T.; Makabe, H.; Matsuda, F.; Miura, D.; Miyashita, M.;Nakamura, T.; Tanaka, K.; Yamamoto, A.
Mass Spectrometry, 3, S0039, Sep. 2014

Synthetic studies on miraziridine A, a cysteine protease inhibitor isolated from Theonella aff. mirabilis
Konno, H.*; Kubo, K.; Makabe, H.; Nosaka, K.; Akaji, K.
Peptide Science, 43, 37-38, 2007

Synthetic studies of tokaramide A and miraziridine A isolated from marine sponge Theonella aff. mirabilis
Konno, H.*; Kubo, K.; Makabe, H.; Fujii, N.; Nosaka, K.; Akaji, K.
Peptide Science, 42, 47-50, 2006

研究小集会報告　「根岸英一先生講演会」
真壁秀文
日本農芸化学会誌, 75(10), 49-50, Oct. 2001

Frontiers in Natural Product Chemistry 3
Hattori, Y.; Makabe, H.*, Joint work, The Biological Activities and Synthesis of 2,6-Disubstituted Piperidinols
182-206 Jun. 2017, Refereed

Studies in Natural Products Chemistry, Atta-Ur-Rahman Eds 48
Makabe, H.*, Studies on prodelphinidins: isolation, synthesis, and their biological activities
ELSEVIER SCIENCE PUBLISHERS - AMSTERDAM, 323-346 Jun. 2016

Studies in Natural Products Chemistry, Atta-Ur-Rahman Eds 42
Makabe, H., Recent progress of the synthesis of 2,6-disubstituted hydroxypiperidine alkaloids
ELSEVIER SCIENCE PUBLISHERS - AMSTERDAM, 353-371 2014, Refereed

Tea in Health and Disease Prevention, Academic Press
Makabe, H., (-)-Epicatechin 3-(3”-O-methylgallate) and (+)-catechin 3-(3”-O-methylgallate), and Their anti-inflammatory activity
Elsevier, Victor R. Preedy Eds., 1215-1222 2012, Refereed

みすずかる信濃の健康志向食品、９章昆虫食の時代がやってくる！
信大大学院機能性食料開発学専攻編, Joint work
郷土出版社, 158-168頁 Sep. 2003

Reactions of Acylpalladium Derivativeswith Enolates and Related Amphiliphilic Reactions, Handbook of Organopalladium Chemistry, VI.2.3
Negishi, E.*; Makabe, H., Joint work
Wiley-VCH, 2455-2471頁 Jul. 2002

Palladium-Catalyzed Hydrometallation, Handbook of Organopalladium Chemistry, VII.4
Makabe, H.; Negishi, E.*, Joint work
Wiley-VCH, 2789-2823頁 Jul. 2002

Synthetic Studies on Natural Products
1992 - 2004

Elsevier, Certificate of Outstanding Contribution in Reviewing in Bioorganic & Medicinal Chemistry Letters, 2016 - 2016

Elsevier, Certificate of Outstanding Contribution in Reviewing Tetrahedron (Elsevier), 2014 - 2014