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YONEKURA Shinichi

Academic OrganizationAcademic Assembly School of Science and Technology Institute of AgricultureTEL
Education and Research OrganizationInterdisciplinary Cluster for Cutting Edge Research, Institute for Biomedical SciencesFAX
PositionProfessorMail Addressyonekura@shinshu-u.ac.jp
Address8304 Minami-Minowa, Nagano, 399-4598 JapanWeb sitehttp://www.shinshu-u.ac.jp/faculty/agriculture/lab/yonekura/top/top.html

Profile

Research Field
Animal Physiology
Keywords:Neuroscience , Cell Physiology
Current Subject
Elucidation of the intracellular mechanism related to milk yield of mammary epithelial cells
Keywords:Mammary gland , 乳量 , 乳牛
Elucidation of in vivo mechanisms associated with perinatal diseases in dairy cows
Keywords:Perinatal diseases , 周産期疾病
Molecular mechanisms regulating myogenic determination and differentiation.
Keywords:Molecular mechanisms regulating myogenic determination and differentiation.
Academic Societies
Academic Societies
The Molecular Biology Society of Japan
Japanese Society of Animal Science
北信越畜産学会
American Dairy Science Association

Committee of Academic Societies
北信越畜産学会 , 評議員
Academic Background
Graduate School
Tohoku University , (Graduate School of Agricultural Science) , 2002
Tohoku University , (Graduate School of Agricultural Science) , 1999

College
Tohoku University , (Faculty of Agriculture) , 1997

Degree
Ph.D. , Tohoku University
Awards
2023 , 日本畜産学会賞
2023 , Animal Science Journal Reviewers Award
2006 , Fellows Award for Research Excellence in NIH
2004 , Award for Young Scientist from Japanese Society of Animal Science

Research

Books, Articles, etc.
Books
新編 家畜生理学
養賢堂 2015
Author:加藤和雄・古瀬充宏・盧尚建・山崎淳・佐野宏明・麻生久・野地智法・米倉真一・萩野顕彦・林英明


Articles
Effects of starvation-induced negative energy balance on endoplasmic reticulum stress in the liver of cows
ANIMAL BIOSCIENCE,35(1):22-28 2022(Jan.)
Author:Islam, Md Aminul; Adachi, Shuya; Shiiba, Yuichiroh; Takeda, Ken-ichi; Haga, Satoshi; Yonekura, Shinichi*;
Keywords:Dairy Cow; Endoplasmic Reticulum Stress; Fasting; Liver; Negative Energy Balance;


Mild heat stimulation facilitates muscle hypertrophy in C2C12 and mouse satellite cells through myokine release to the culture medium
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,635:161-168 2022
Author:Hayashi, Satoko; Yonekura, Shinichi*;
Keywords:Mild heat stimulation; Decorin; Muscle hypertrophy; Conditioned medium; C2C12 cell; Satellite cell;


XBP1u Is Involved in C2C12 Myoblast Differentiation via Accelerated Proteasomal Degradation of Id3
FRONTIERS IN PHYSIOLOGY,13:796190 2022
Author:Hayashi, Satoko; Sakata, Shotaro; Kawamura, Shotaro; Tokutake, Yukako; Yonekura, Shinichi*;
Keywords:skeletal muscle differentiation; cell cycle exit; unfolded protein response; Id3; cyclin-dependent kinase inhibitor;


Insulin-like growth factor-1 induces IRE1-XBP1-dependent endoplasmic reticulum biogenesis in bovine mammary epithelial cells
JOURNAL OF DAIRY SCIENCE,104(11):12094-12104 2021(Nov.)
Author:Sharmin, Mst Mamuna; Hayashi, Satoko; Miyaji, Makoto; Ishizaki, Hiroshi; Matsuyama, Hiroki; Haga, Satoshi; Yonekura, Shinichi*;
Keywords:mammary epithelial cell; endoplasmic reticulum biogenesis; IGF-1; unfolded protein response;


Protective effects of 5-aminolevulinic acid on heat stress in bovine mammary epithelial cells
ANIMAL BIOSCIENCE,34(6):1006-1013 2021(Jun.)
Author:Islam, Md Aminul; Noguchi, Yoko; Taniguchi, Shin; Yonekura, Shinichi*;


Myogenetic oligodeoxynucleotide (myoDN) recovers the differentiation of skeletal muscle myoblasts deteriorated by diabetes mellitus.
Frontiers in Physiology,12:679152 2021(May 24)
Author:Nakamura, Shunichi; Yonekura, Shinichi; Shimosato, Takeshi; Takaya, Tomohide


5-ALA Attenuates the Palmitic Acid-Induced ER Stress and Apoptosis in Bovine Mammary Epithelial Cells
MOLECULES,26(4) 2021(Feb.)
Author:Sharmin, Mst Mamuna; Islam, Md Aminul; Yamamoto, Itsuki; Taniguchi, Shin; Yonekura, Shinichi*;


Effects of fatty acids on inducing endoplasmic reticulum stress in bovine mammary epithelial cells
JOURNAL OF DAIRY SCIENCE,103(9):8643-8654 2020(Sep.)
Author:Sharmin, Mst Mamuna; Mizusawa, Moeko; Hayashi, Satoko; Arai, Wataru; Sakata, Shotaro; Yonekura, Shinichi*;


TRPV4 Increases the Expression of Tight Junction Protein-Encoding Genes via XBP1 in Mammary Epithelial Cells
ANIMALS,10(7) 2020(Jul.)
Author:Islam, Md Aminul; Mizusawa, Moeko; Sharmin, Mst Mamuna; Hayashi, Satoko; Yonekura, Shinichi*;


IRE1-XBP1 Pathway of the Unfolded Protein Response Is Required during Early Differentiation of C2C12 Myoblasts
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,21(1) 2020
Author:Tokutake, Yukako; Yamada, Keita; Hayashi, Satoko; Arai, Wataru; Watanabe, Takafumi; Yonekura, Shinichi*;


Thermal stimulation at 39 degrees C facilitates the fusion and elongation of C2C12 myoblasts
ANIMAL SCIENCE JOURNAL,90(8):1008-1017 2019(Aug.)
Author:Hayashi, Satoko; Yonekura, Shinichi*;


Mild heat stress induces transcription of the beta-casein gene via unfolded protein response-activated XBP1 signaling in undifferentiated mammary epithelial cells
ANIMAL SCIENCE JOURNAL,90(8):1026-1032 2019(Aug.)
Author:Mizusawa, Moeko; Sharmin, Mamuna; Yonekura, Shinichi*;


Adzuki bean (Vigna angularis) extract reduces amyloid- beta aggregation and delays cognitive impairment in Drosophila models of Alzheimer's disease
NUTRITION RESEARCH AND PRACTICE,13(1):64-69 2019(Feb.)
Author:Miyazaki, Honami; Okamoto, Yoko; Motoi, Aya; Watanabe, Takafumi; Katayama, Shigeru; Kawahara, Sei-ichi; Makabe, Hidefumi; Fujii, Hiroshi; Yonekura, Shinichi*;


Peg1/Mest, an imprinted gene, is involved in mammary gland maturation
JOURNAL OF CELLULAR PHYSIOLOGY,234(2):1080-1087 2019(Feb.)
Author:Yonekura, Shinichi*; Ohata, Masaki; Tsuchiya, Megumi; Tokita, Hitomi; Mizusawa, Moeko; Tokutake, Yukako;


骨格筋分化の制御に寄与するIRE1-XBP1の機能解明
栄養生理研究会報 = Reviews on Animal Nutrition and Metabolism,63(1):15-22 2019
Author:徳武 優佳子;山田 啓太;林 聡子;坂田 章太郎;米倉 真一


The unfolded protein response is involved in both differentiation and apoptosis of bovine mammary epithelial cells
JOURNAL OF DAIRY SCIENCE,101(4):3568-3578 2018(Apr.)
Author:Yonekura, Shinichi*; Tsuchiya, Megumi; Tokutake, Yukako; Mizusawa, Moeko; Nakano, Miwa; Miyaji, Makoto; Ishizaki, Hiroshi; Haga, Satoshi;


The role of unfolded protein response in differentiation of mammary epithelial cells
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,484(4):903-908 2017
Author:Tsuchiya, Megumi; Koizumi, Yumiko; Hayashi, Satoko; Hanaoka, Miyuki; Tokutake, Yukako; Yonekura, Shinichi*


Subcellular Localization and Polymorphism of Bovine FABP4 in Bovine Intramuscular Adipocytes
ANIMAL BIOTECHNOLOGY,27(2):96-103 2016
Author:Yonekura, Shinichi*; Hirota, Shohei; Miyazaki, Honami; Tokutake, Yukako;


ALS-Linked P56S-VAPB Mutation Impairs the Formation of Multinuclear Myotube in C2C12 Cells
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,16(8):18628-18641 2015(Aug.)
Author:Tokutake, Yukako; Yamada, Keita; Ohata, Masaki; Obayashi, Yoshihito; Tsuchiya, Megumi; Yonekura, Shinichi*


Soluble extract of soybean fermented with Aspergillus oryzae GB 107 inhibits fat accumulation in cultured 3T3-L1 adipocytes
NUTRITION RESEARCH AND PRACTICE,9(4):439-444 2015(Aug.)
Author:So, Kyoung-Ha; Suzuki, Yasuki; Yonekura, Shinichi; Suzuki, Yutaka; Lee, Chan Ho; Kim, Sung Woo; Katoh, Kazuo; Roh, Sang-Gun;


Inhibitory/Suppressive Oligodeoxynucleotide Nanocapsules as Simple Oral Delivery Devices for Preventing Atopic Dermatitis in Mice
MOLECULAR THERAPY,23(2):297-309 2015(Feb.)
Author:Wang, Yeqin; Yamamoto, Yoshinari; Shigemori, Suguru; Watanabe, Takafumi; Oshiro, Kazushi; Wang, Xinyu; Wang, Pengfei; Sato, Takashi; Yonekura, Shinichi; Tanaka, Sachi; Kitazawa, Haruki; Shimosato, Takeshi;


ALS-associated P56S-VAPB mutation restrains 3T3-L1 preadipocyte differentiation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,460(3):831-837 2015
Author:Tokutake, Yukako; Gushima, Kazunari; Miyazaki, Honami; Shimosato, Takeshi; Yonekura, Shinichi*


Histological analysis of glucagon-like peptide-1 receptor expression in chicken pancreas
CELL AND TISSUE RESEARCH,357(1):55-61 2014(Jul.)
Author:Watanabe, Takafumi; Nishimura, Kei; Hosaka, Yoshinao Z.; Shimosato, Takeshi; Yonekura, Shinichi; Suzuki, Daisuke; Takemoto, Chihiro; Monir, Mohammad Moniruzzaman; Hiramatsu, Kohzy;


Effect of single nucleotide polymorphisms in GH gene promoter region on carcass traits and intramuscular fatty acid compositions in Japanese Black cattle
LIVESTOCK SCIENCE,165:15-21 2014(Jul.)
Author:Sugita, Haruna; Ardiyanti, Astrid; Yokota, Shoko; Yonekura, Shinichi; Hirayama, Takuji; Shoji, Noriaki; Yamauchi, Eri; Suzuki, Keiichi; Katoh, Kazuo; Roh, Sang-Gun;


Influences of protein ingestion on glucagon-like peptide (GLP)-1-immunoreactive endocrine cells in the chicken ileum
ANIMAL SCIENCE JOURNAL,85(5):581-587 2014(May)
Author:Monir, Mohammad M.; Hiramatsu, Kohzy; Matsumoto, Sachiko; Nishimura, Kei; Takemoto, Chihiro; Shioji, Tomomi; Watanabe, Takafumi; Kita, Kazumi; Yonekura, Shinichi; Roh, Sang Gun


Dexamethasone and Acetate Modulate Cytoplasmic Leptin in Bovine Preadipocytes
ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES,27(4):567-573 2014(Apr.)
Author:Yonekura, Shinichi*; Hirota, Shohei; Tokutake, Yukako; Rose, Michael T.; Katoh, Kazuo; Aso, Hisashi


Proliferating bovine intramuscular preadipocyte cells synthesize leptin
DOMESTIC ANIMAL ENDOCRINOLOGY,45(1):33-37 2013(Jul.)
Author:Yonekura, S*.; Tokutake, Y.; Hirota, S.; Rose, M. T.; Katoh, K.; Aso, H.


Expression of the immunoreactive buckwheat major allergenic storage protein in Lactococcus lactis
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,97(8):3603-3611 2013(Apr.)
Author:Shigemori, Suguru; Yonekura, Shinichi; Sato, Takashi; Otani, Hajime; Shimosato, Takeshi


Expression of a Biologically Active GFP-alpha(S1)-Casein Fusion Protein in Lactococcus lactis
CURRENT MICROBIOLOGY,64(6):569-575 2012(Jun.)
Author:Shigemori, Suguru; Yonekura, Shinichi; Sato, Takashi; Nakanishi, Maya; Otani, Hajime; Shimosato, Takeshi


AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster
JOURNAL OF CELL SCIENCE,125(3):634-648 2012(Feb. 01)
Author:Kametaka, Satoshi; Kametaka, Ai; Yonekura, Shinichi; Haruta, Mineyuki; Takenoshita, Seiichi; Goto, Satoshi; Waguri, Satoshi


Conserved Alternative Splicing and Expression Patterns of Arthropod N-Cadherin
PLOS GENETICS,5(4) 2009(Apr.)
Author:Hsu, Shu-Ning; Yonekura, Shinichi; Ting, Chun-Yuan; Robertson, Hugh M.; Iwai, Youichi; Uemura, Tadashi; Lee, Chi-Hon; Chiba, Akira


Tiling of R7 axons in the Drosophila visual system is mediated both by transduction of an activin signal to the nucleus and by mutual repulsion
NEURON,56(5):793-806 2007(Dec. 06)
Author:Ting, Chun-Yuan; Herman, Tory; Yonekura, Shinichi; Gao, Shuying; Wang, Jian; Serpe, Mihaela; O'Connor, Michael B.; Zipursky, S. Lawrence; Lee, Chi-Hon


Alternative splicing expands spatiotemporal expression complexity of arthropod N-Cadherin
DEVELOPMENTAL BIOLOGY,306(1):376-376 2007(Jun. 01)
Author:Hsu, Shu-Ning; Yonekura, Shinichi; Ting, Chun-Yuan; Robertson, Hugh M.; Lee, Chi-Hon; Chiba, Akira


Adhesive but not signaling activity of Drosophila N-cadherin is essential for target selection of photoreceptor afferents
DEVELOPMENTAL BIOLOGY,304(2):759-770 2007(Apr. 15)
Author:Yonekura, Shinichi; Xu, Lei; Ting, Chun-Yuan; Lee, Chi-Hon


The variable transmembrane domain of Drosophila N-cadherin regulates adhesive activity
MOLECULAR AND CELLULAR BIOLOGY,26(17):6598-6608 2006(Sep.)
Author:Yonekura, Shinichi; Ting, Chun-Yuan; Neves, Guilherme; Hung, Kimberly; Hsu, Shu-ning; Chiba, Akira; Chess, Andrew; Lee, Chi-Hon


Growth hormone and lactogenic hormones can reduce the leptin mRNA expression in bovine mammary epithelial cells
DOMESTIC ANIMAL ENDOCRINOLOGY,31(1):88-96 2006(Jul.)
Author:Yonekura, S; Sakamoto, K; Komatsu, T; Hagino, A; Katoh, K; Obara, Y


Drosophila N-cadherin functions in the first stage of the two-stage layer-selection process of R7 photoreceptor afferents
DEVELOPMENT,132(5):953-963 2005(Mar.)
Author:Ting, CY*; Yonekura, S*; Chung, P; Hsu, SN; Robertson, HM; Chiba, A; Lee, CH. *contributed equally to this work.


Octanoate stimulates cytosolic triacylglycerol accumulation and CD36 mRNA expression but inhibits Acetyl coenzyme A carboxylase activity in primary cultured bovine mammary epithelial cells
JOURNAL OF DAIRY RESEARCH,71(4):398-404 2004(Nov.)
Author:Yonezawa, T; Yonekura, S; Sanosaka, M; Hagino, A; Katoh, K; Obara, Y


Effects of long-chain fatty acids on cytosolic triacylglycerol accumulation and lipid droplet formation in primary cultured bovine mammary epithelial cells
JOURNAL OF DAIRY SCIENCE,87(8):2527-2534 2004(Aug.)
Author:Yonezawa, T; Yonekura, S; Kobayashi, Y; Hagino, A; Katoh, K; Obara, Y


Suppressing effects of bisphenol A on the secretory function of ovine anterior pituitary cells
CELL BIOLOGY INTERNATIONAL,28(6):463-469 2004
Author:Katoh, K; Matsuda, A; Ishigami, A; Yonekura, S; Ishiwata, H; Chen, C; Obara, Y


Effects of acetate and butyrate on the expression of leptin and short-form leptin receptor in bovine and rat anterior pituitary cells
GENERAL AND COMPARATIVE ENDOCRINOLOGY,133(2):165-172 2003(Sep.)
Author:Yonekura, S; Senoo, T; Kobayashi, Y; Yonezawa, T; Katoh, K; Obara, Y


In vitro differentiation of a cloned bovine mammary epithelial cell
JOURNAL OF DAIRY RESEARCH,69(3):345-355 2002(Aug.)
Author:Rose, MT; Aso, H; Yonekura, S; Komatsu, T; Hagino, A; Ozutsumi, K; Obara, Y


Effects of nutritional conditions around weaning on carbonic anhydrase activity in the parotid gland and ruminal and abomasal epithelia of Holstein calves
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY,172(5):379-385 2002(Jul.)
Author:Kitade, K; Takahashi, K; Yonekura, S; Katsumata, N; Furukawa, G; Ohsuga, S; Nishita, T; Katoh, K; Obara, Y


Effects of aging and weaning on mRNA expression of leptinand CCK receptors in the calf rumen and abomasum
DOMESTIC ANIMAL ENDOCRINOLOGY,22(1):25-35 2002(Mar.)
Author:Yonekura, S; Kitade, K; Furukawa, G; Takahashi, K; Katsumata, N; Katoh, K; Obara, Y


Relationship between serum leptin concentrations and the marbling scores in Japanese Black Cattle.
Anim Sci J,22:25-35 2002
Author:Yonekura S, Kitade K, Furukawa G, Takahashi K, Katsumata N, Katoh K, Obara Y.


Effects of adenosine 5'-triphosphate and growth hormone on cellular H+ transport and calcium ion concentrations in cloned bovine mammary epithelial cells
JOURNAL OF ENDOCRINOLOGY,169(2):381-388 2001(May)
Author:Katoh, K; Komatsu, T; Yonekura, S; Ishiwata, H; Hagino, A; Obara, Y

Research Grants
Grants‐in‐aid for Scientific Research(Research Representative)
2020 - 2022 , 乳腺の小胞体ストレス応答機構に着眼した泌乳制御機序解明と泌乳平準化研究への新展開 , 基盤研究(B)
2017 - 2019 , 小胞体ストレス応答機構に着目した筋肥大化メカニズムの解明 , 基盤研究(C)