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Academic OrganizationTEL
Education and Research OrganizationGraduate School of Medicine, Science and TechnologyFAX
PositionAssociate ProfessorMail Addressnkanayama[at]
Address4-17-1, Wakasato, Nagano 380-8553Web site


Research Field
Bio-related polymers
Colloid & Interface Science
Analytical chemistry
Biophysical chemistry
2018 , The 79th JSAP (The Japan Society of Applied Physics) Autum Meeting 2018 Postar Award
2017 , Inside Front Cover (Wiley-VCH, Small 2017, 13, 1702137)
2016 , Front Cover (Wiley-VCH, ChemistryOPEN 2016, 5, 508)
2016 , ACS Editor’s Choice (American Chemical Society, Langmuir 2016, 32, 13296)
2015 , Front Cover (Wiley-VCH, Small 2015, 11, 3153)
2014 , Front Cover (Royal Society of Chemistry, Biomaterials Science, 2014, 2, 819)
2013 , Frontispiece (Wiley-VCH, Chemistry –A European Journal, 2013, 19, 10794)
2011 , Cover Picture (Wiley-VCH, Macromolecular Bioscience 2011, 11, 187)
2010 , Editor’s Choice (Chemical Society of Japan, Chemistry Letters 2010, 39, 1008)
2006 , Cover Picture (Wiley-VCH, ChemMedChem 2006, 1, 439)


Books, Articles, etc.
ファルマシア , 54(1):31-35 2018

工業材料 , 65(7):43-49 2017

高分子 , 66(3):110-112 2017

バイオマテリアル , 34:180-184 2016

人工臓器 , 44:182-185 2015

バイオマテリアル , 32:95-101 2014

エヌ・ティー・エス出版 , 先端バイオマテリアルハンドブック , :418-422 2012

DNA担持ナノ粒子 ~その奇妙な性質とバイオ応用~
CSJ CurrentReview09 金属および半導体ナノ粒子の科学(日本化学会編) , :124-132 2012

ぶんせき , 450:307-311 2012

ファルマシア , 46(4):317-322 2010

第5章 バイオ計測技術 2. DNAコンジュゲートポリマーによるバイオ計測
シーエムシー出版 , 次世代医療のための高分子材料工学 , :252-262 2008

Development of Supramolecular Nanocarrier for Gene Delivery Based on Cationic Block Copolymers
Springer , Non-viral Gene Therapy , :51-62 2005
Author:Yuichi Yamasaki, Woo-Dong Jang, Nobuhiro Nishiyama, Naoki Kanayama, Kazunori Kataoka

高分子加工 , 49(6):242-250 2000

DNA の相補的結合作用を利用したナノ粒子の構造化
高分子 , 46(2):86 1997

Production of extracellular polysaccharides and phycobiliproteins from Tolypothrix sp. PCC7601 using mechanical milking systems
Algal Research 2020
Author:Alice Uchida、Yukiko Higashi、Shota Yamamoto、Jun Nakanishi、Naoki Kanayama、Kazuhiro Shibata、Masaki Ihara

Non-Crosslinking Aggregation of DNA-Functionalized Gold Nanoparticles for Gene Diagnosis and Directed Assembly
ACS Symposium Series,1309:119-138 2019
Author:Guoqing Wang, Yoshitsugu Akiyama, Naoki Kanayama, Tohru Takarada, Mizuo Maeda

Evapolative Crystallization of Dibenzoylmethanato Boron Difuluoride Probed by Time-Resolved Quartz Crystal Microbalance Responses with Fluorescence Changes
Chemistry Letters,48:1199-1202 2019
Author:Fuyuki Ito, Mai Saigusa, Naoki Kanayama

Chemically Fueled Plasmon Switching of Gold Nanorods by Single-Base Pairing of Surface-Grafted DNA
Langmuir,35:11710-11716 2019
Author:Lan Zhang, Chenlin Zhao, Yao Zhang, Luyang Wang, Guoqing Wang, Naoki Kanayama, Tohru Takarada, Mizuo Maeda, Xingguo Liang

Stochastic Binding Process of Blunt-End Stacking of DNA Molecules Observed by Atomic Force Microscopy
Langmuir,34:15078-15083 2018
Author:Taito Sekine, Naoki Kanayama*, Kazunari Ozasa, Takashi Nyu, Tomohiro Hayashi*, Mizuo Maeda

Cross-Linking versus Non-Cross-Linking Aggregation of Gold Nanoparticles Induced by DNA Hybridization: A Comparison of the Rapidity of Solution Color Change
Bioconjugate Chemistry,28:270-277 2017
Author:Guoqing Wang, Yoshitsugu Akiyama, Shota Shiraishi, Naoki Kanayama, Tohru Takarada, Mizuo Maeda

Directed Assembly of Gold Nanorods by Terminal-Base Pairing of Surface-Grafted DNA
Small,13:1702137 2017
Author:Guoquin Wang, Yoshitsugu Akiyama, Naoki Kanayama, Tohru Takarada, Mizuo Maeda

Rapid Naked-Eye Discrimination of Cytochrome P450 Genetic Polymorphism via Non-Crosslinking Aggregation of DNA-Functionalized Gold Nanoparticles
ChemistryOPEN,5:508-512 2016
Author:Yoshitsugu Akiyama, Guoqing Wang, Shota Shiraishi, Naoki Kanayama, Tohru Takarada, Mizuo Maeda

Terminal-Specific Interaction between Double-Stranded DNA Layers: Colloidal Dispersion Behavior and Surface Force
Langmuir,32:13296-13304 2016
Author:Naoki Kanayama, Taito Sekine, Kazunari Ozasa, Satomi Kishi, Takashi Nyu, Tomohiro Hayashi, Mizuo Maeda

Modulation of Interparticle Distance in Discrete Gold Nanoparticle Dimers and Trimers by DNA Single-Base Pairing
Small,11:11425-11433 2015
Author:Yoshitugu Akiyama, Hiroto Shikagawa, Naoki Kanayama, Tohru Takarada, Mizuo Maeda

Sulfobetaine-terminated PEG improves the qualities of an immunosensing surface
Biomaterials Science,2:819-826 2014
Author:Yukichi Horiguchi, Naoki Nakayama, Naoki Kanayama, Yukio Nagasaki

DNA dangling-end-induced colloidal stabilization of gold nanoparticles for colorimetric single-nucleotide polymorphism genotyping
Chemistry –A European Journal,20:17420-17425 2014
Author:Yoshitugu Akiyama, Hiroto Shikagawa, Naoki Kanayama, Tohru Takarada, Mizuo Maeda

Thermodynamics-Based Rational Design of DNA Block Copolymers for Quantitative Detection of Single-Nucleotide Polymorphisms by Affinity Capillary Electrophoresis
Analytical Chemistry,85:3153-3161 2014
Author:Ayumi Kimura, Naoki Kanayama, Atsushi Ogawa, Hideaki Shibata, Hideo Nakashita, Tohru Takarada, and Mizuo Maeda

Quantitative single-nucleotide polymorphism analysis in secondary-structured DNA by affinity capillary electrophoresis using a polyethylene glycol–peptide nucleic acid block copolymer
Analytical Biochemistry,433:150-152 2013
Author:Harumi Tsukada, Lal Mohan Kundu, Yukiharu Matsuoka, Naoki Kanayama, Tohru Takarada, Mizuo Maeda

Dumbbell-shaped DNA analytes amplified by polymerase chain reaction for robust single-nucleotide polymorphism genotyping by affinity capillary electrophoresis
Analytical Chemistry,85:5347-5352 2013
Author:Hideaki Shibata, Atsushi Ogawa, Naoki Kanayama, Tohru Takarada, Mizuo Maeda

DNA terminal breathing regulated by metal ions for colloidal logic gates
Chemistry –A European Journal,19:10794-10798 2013
Author:Naoki Kanayama, Tohru Takarada, Masahiro Fujita, Mizuo Maeda

DNA terminal mismatch-induced stabilization of polymer micelles from RAFT-generated poly(N-isopropyl acrylamide)-DNA block copolymers
Chemistry –An Asian Journal,8:3079-3084 2013
Author:Kyousuke Isoda, Naoki Kanayama, Masahiro Fujita, Tohru Takarada, Mizuo Maeda

Structural study on non-crosslinking aggregation of gold nanoparticles with DNA
Journal of Colloid and Interface Science,369:629-635 2012
Author:Masahiro Fujita, Yoshizumi Katafuchi, Kazuki Ito, Naoki Kanayama, Toru Takarada, Mizuo Maeda

Structural characterization of nanoparticles from thermoresponsive poly(N-isopropylacrylamide)-DNA conjugate
Journal of Colloid and Interface Science,374:315-320 2012
Author:Wei-Yang OOI, Masahiro Fujita, Pengju Pan, Hui-Ying Tang, Kumar Sudesh, Kazuki Ito, Naoki Kanayama, Tohru Takarada, Mizuo Maeda

Highly quantitative SNP genotyping by affinity capillary zone electrophoresis using PEG-oligodeoxyribonucleotide block copolymers
Electrophoresis,33:2122-2129 2012
Author:Harumi Tsukada, Takashi Watanabe, Naoki Kanayama, Tohru Takarada, Mizuo Maeda

Preparation and evaluation of highly dispersible and Ca2+ level responsive PEGylated calcium phosphate nanoparticle with PEG-block-poly(4-vinylbenzylphosphonate) for the application of drug carrier
Transactions of the Materials Research Society of Japan,37:337-340 2012
Author:Kei Asai, Naoki Kanayama, Yukio Nagasaki

Estimation of binding constants of PNA and secondary-structured DNA by affinity capillary electrophoresis
Analytical Chemistry,84:5204-5209 2012
Author:Lal Kundu, Harumi Tsukada, Yukiharu Matsuoka, Naoki Kanayama, Tohru Takarada, Mizuo Maeda

Polymer brush with pendent glucosylurea groups constructed on a glass substrate by RAFT polymerization
European Polymer Journal,48:1875-1882 2012
Author:Hiromi Kitano, Yan Liu, Ken-ichi Tokuwa, Lifu Li, Shintarou Iwanaga, Masato Nakamura, Naoki Kanayama, Kohji Ohno, Yoshiyuki Saruwatari

Enzymatic synthesis of poly(β-ethyl aspartate) by polyethylene glycol modified poly(aspartic acid) hydrolase-1
Macromolecular Bioscience,11:187-191 2011
Author:Tomohiro Hiraishi, Eriko Masuda, Daisuke Miyamoto, Naoki Kanayama, Hideki Abe, Mizuo Maeda

RAFT-generated poly(N-isopropylacrylamide)-DNA block copolymers for temperature-responsive formation of polymer micelles
Reactive and Functional Polymers,71:367-371 2011
Author:Kyosuke Isoda, Naoki Kanayama, Tohru Takarada, Mizuo Maeda

Rapid naked-eye detection of mercury ion based on non- crosslinking aggregation of double-stranded DNA carrying gold nanoparticles
Chemical Communications,47:2077-2079 2011
Author:Naoki Kanayama, Tohru Takarada, Mizuo Maeda

In vivo near-infrared bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-block- poly(4-vinylbenzyl phosphonate)
Nanoscale,3:3705-3713 2011
Author:Masao Kamimura, Naoki Kanayama, Kimikazu Tokuzen, Kohei Soga, Yukio Nagasaki

Preparation of highly dispersible and tumor-accumulative, iron oxide nanoparticles: multi-point anchoring of PEG-b-poly(4-vinylbenzylphosphonate) improves performance significantly
Colloids and Surfaces B: Biointerfaces,88:771-778 2011
Author:Kodai Ujiie, Naoki Kanayama, Kei Asai, Mikio Kishimoto, Yusuke Ohara, Yoshimasa Akashi, Keiichi Yamada, Shinji Hashimoto, Tatsuya Oda, Nobuhiro Ohkohchi, Hideto Yanagihara, Eiji Kita, Masayuki Yamaguchi, Hirofumi Fujii, Yukio Nagasaki,

Binding of β-Secretase to a Peptide Inhibitor-Carrying SAM
Colloid and Surfaces B, Biointerface,78:155-162 2010
Author:Hiromi Kitano, Yasuhiro Kondo, Daisuke Saito, Makoto Genmei-Ide, Hiroyuki Morita, Naoki Kanayama

Facile Creation of Biointerface on Commodity Plastic Surface by Combination of Atmospheric Plasma and Reactive Polymer Coating
Journal of Photopolymer Science and Technology,23:579-583 2010
Author:Naoki Kanayama, Swapan Kumar Saha, Naoki Nakayama, Jun Nakanishi, Katsuhisa Kitano, Satoshi Hamaguchi, Yukio Nagasaki

PEGylated polymer micelle-based nitric oxide (NO) photodonor with NO-mediated antitumor activity
Chemistry Letters,39:1008-1009 2010
Author:Naoki Kanayama, Kazuhiro Yamaguchi, Yukio Nagasaki

Cloning of Poly(Aspartic Acid) (PAA) Hydrolase-1 Gene from Pedobacter sp. KP-2 and Hydrolysis of Thermally Synthesized PAA by Its Gene Product
Macromolecular Bioscience,9:10-19 2009
Author:Tomohiro Hiraishi, Eriko Masuda, Madoka Nagata, Naoki Kanayama, Hideki Abe, Yoshiharu Doi, Mizuo Maeda

RAFT-Generated Polyacrylamide-DNA Block Copolymers for Single-Nucleotide Polymorphism Genotyping by Affinity Capillary Electrophoresis
Biomacromolecules,10:805-813 2009
Author:Naoki Kanayama, Ayumi Kimura, Hideaki Shibata, Daisuke Miyamoto, Tohru Takarada, Mizuo Maeda

Anti-Biofouling Property of a Telomer Brush with Pendent Glucosylurea Groups
Langmuir,25:9361-9368 2009
Author:Hiromi Kitano, Atsushi Hayashi, Hajime Takakura, Hisatomo Suzuki, Naoki Kanayama, Yoshiyuki Saruwatari

Affinity Capillary Electrophoretic DNA Separation Using PEG-Oligodeoxyribonucleotide Block Copolymers: Relationship between Peak Resolution and Affinity Strength
Journal of Separation Science,31:837-844 2008
Author:Naoki Kanayama, Tohru Takarada, Ayumi Kimura, Hideaki Shibata, Mizuo Maeda

Evaluation of Single-Base Substitution Rate in DNA by Affinity Capillary Electrophoresis
Analytica Chimica Acta,619:101-109 2008
Author:Naoki Kanayama, Tohru Takarada, Hideaki Shibata, Ayumi Kimura, Mizuo Maeda

Poly(Ethylene Glycol)-oligodeoxyribonucleotide Block Copolymers for Affinity Capillary Electrophoretic Separation of Single-stranded DNAs with a Single-base Difference
Reactive and Functional Polymers,67:1373-1380 2007
Author:Naoki Kanayama, Ayumi Kimura, Hideaki Shibata, Tohru Takarada, Mizuo Maeda

Cyclic RGD Peptide-Conjugated Polyplex Micelles as a Targetable Gene Delivery System Directing to Cells Possessing αvβ3 and αvβ5 Integrins
Bioconjugate Chemistry,18:1415-1423 2007
Author:Makoto Oba, Shigeto Fukushima, Naoki Kanayama, Kazuhiro Aoyagi, Nobuhiro Nishiyama, Hiroyuki Koyama, Kazunori Kataoka

Detection of base pairing of an oxidatively damaged guanine using colloidal stability change of DNA-linked polymer micelles
Nucleic Acids Symp. Series,51:305-306 2007
Author:Tohru Takarada, Emi Imaizumi, Katsuhito Kino, Keitaro Yoshimoto, Shinzi Ogasawara, Naoki Kanayama, Mizuo Maeda

Point Mutation Assay by Affinity Capillary Electrophoresis Using Poly(ethylene glycol)- oligodeoxyribonucleotide block copolymers
Nucleic Acids Symp. Series,51:337-338 2007
Author:Ayumi Kimura, Tohru Takarada, Naoki Kanayama, Hideaki Shibata, Mizuo Maeda

SAXS Measurement of Aggregate of DNA Modified Gold Nanoparticles
Nucleic Acids Symp. Series,51:335-336 2007
Author:Shizuto Yamakoshi, Yasuhiro Sakai, Yuuya Shinohara, Yoshiyuki Amemiya, Naoki Kanayama, Tohru Takarada, Mizuo Maeda, Kohzo Ito

A PEG-Based Biocompatible Block Catiomer with High Buffering Capacity for the Construction of Polyplex Micelles Showing Efficient Gene Transfer toward Primary Cells
ChemMedChem,1:439-444 2006
Author:Naoki Kanayama, Shigeto Fukushima, Nobuhiro Nishiyama, Keiji Itaka, Woo-Dong Jang, Kanjiro Miyata, Yuichi Yamasaki, Ung-il Chung, Kazunori Kataoka

PEGylated Gene Nanocarriers Based on Block Catiomers Bearing Ethylenediamine Repeating Units Directed to Remarkable Enhancement of Photochemical Transfection
Journal of Controlled Release,115:208-215 2006
Author:Arnida, Nobuhiro Nishiyama, Naoki Kanayama, Woo-Dong Jang, Yuichi Yamasaki, Kazunori Kataoka

PEGlated Polyplex Micelles from Triblock Catiomers with Spatially Ordered Layering of Condensed pDNA and Buffering Units for Enhanced Intracellular Gene Delivery
Journal of The American Chemical Society,127:2810-2811 2005
Author:Shigeto Fukushima, Kanjiro Miyata, Nobuhiro Nishiyama, Naoki Kanayama, Yuichi Yamasaki, Kazunori Kataoka

Lactose-Conjugated Polyion Complex Micelles Incorporating Plasmid DNA as a Targetable Gene Vector System: Their Preparation and Gene Transfecting Efficiency Against HepG2 Cells
Journal of Controlled Release,95:653-664 2004
Author:Daisuke Wakebayashi, Nobuhiro Nishiyama, Yuichi Yamasaki, Keiji Itaka, Naoki Kanayama, Atsushi Harada, Yukio Nagasaki, Kazunori Kataoka

Supramolecular Nanocarrier of siRNA from PEG-Based Block Catiomer Carrying Diamine Side Chain with Distinctive pKa Directed to Enhance Intercellular Silencing
Journal of The American Chemical Society,126:13612-13613 2004
Author:Keiji Itaka, Naoki Kanayama, Nobuhiro Nishiyama, Woo-Dong Jang, Yuichi Yamasaki, Kozo Nakamura, Hiroshi Kawaguchi, Kazunori Kataoka

Substrate Monolayers as Electrochemical Sensing Elements for α-Chymotrypsin
Journal of Colloid and Interface Science,250:134-141 2002
Author:Hiromi Kitano, Toshitaka Saito, Naoki Kanayama

Distinct Thermodynamic Behaviour of a Mesomorphic Gold Nanoparticle Covered with a Liquid-Crystalline Compound
Chemical Communications,:2640-2641 2001
Author:Naoki Kanayama, Osamu Tsutsumi, Akihiko Kanazawa, Tomiki Ikeda

Interfacial Recognition of Sugars by Boronic Acid Carrying Self-Assembled Monolayer
Langmuir,16:577-583 2000
Author:Naoki Kanayama, Hiromi Kitano

Complexation of Porphyrin with a Pyridine Moiety in Self-Assembled Mnolayers on Metal Surfaces
The Journal of Physical Chemistry B,104:271-278 2000
Author:Naoki Kanayama, Takaki Kanbara, Hiromi Kitano

Self-Assembled Monolayer of Sugar-Carrying Polymer Chain: Sugar Balls from 2-Methacryloyloxyethyl D-Glucopyranoside
Langmuir,15:482-488 1999
Author:Akira Yoshizumi, Naoki Kanayama, Yukari Maehara, Makoto Ide, Hiromi Kitano

Interfacial Recognition of Sugars by Novel Boronic Acid-Carrying Amphiphiles Prepared With a Lipophilic Radical Initiator
Langmuir,14:165-170 1998
Author:Hiromi Kitano, Mai Kuwayama, Naoki Kanayama, Kohji Ohno

Research Grants
Joint Research
2018 - 2019 , 機能性新高分子テープの開発・実用化研究

Grants‐in‐aid for Scientific Research(Research Representative)
2020 - , 末端スタッキング駆動型DNAリン酸化プローブの創出と機能検証 , 基盤研究C
2017 - 2020 , DNAブラシ界面間力の表層構造依存性に基づく「水和スイッチ」の創出 , 基盤研究C
2014 - 2017 , DNAブラシ界面間における特異な相互作用の発現に対する水和状態の寄与評価 , 基盤研究C
2012 - 2013 , 界面特性の異なる高密度DNAブラシを担持したナノ粒子の創製と細胞との相互作用評価 , 若手研究B
2009 - 2010 , 機能性微小空間を付与したDNAナノ粒子を用いる有害金属イオンの簡便・迅速検出 , 若手研究B
2007 - 2008 , DNA担持ポリマーナノミセルの精密構造制御と高感度センシングデバイスへの応用 , 若手研究B

Grants‐in‐aid for Scientific Research(Researcher)
2017 - 2019 , 固液界面現象解明のための溶液化学反応における電子状態ダイナミクス計測開発 , 基盤研究B
2013 - 2017 , DNAソフト界面の特性を活かしたバイオマテリアルの創製 , 基盤研究S

Other Research Grants
2017 - 2017 , CpGオリゴDNA複合化ポリマーの構造と免疫賦活効果の相関評価(平成29年度 生体医歯工学共同研究拠点共同研究プロジェクト)

2004 - 2004 , 「トロイの木馬」方式による高分子ナノコンポジット材料の簡便・安価な製造プロセスの開発に関する研究(平成16年度 小笠原科学技術振興財団研究助成金)


Basic Chemistry for The Environment and Life
Introduction to Science Literacy
Carrier Design as Graduate Students Aiming at Researchers and Engineers