博士（理学）, 総合研究大学院大学

Functional biochemistry

Biochemistry

Non-vesicular extracellular RNA: A potential drug target to intervene cell-cell communication.
Takeshi Tomita
Pharmacology & therapeutics, 108774-108774, Dec. 2024

Citrullinated fibrinogen-SAAs complex causes vascular metastagenesis.
Yibing Han; Takeshi Tomita; Masayoshi Kato; Norihiro Ashihara; Yumiko Higuchi; Hisanori Matoba; Weiyi Wang; Hikaru Hayashi; Yuji Itoh; Satoshi Takahashi; Hiroshi Kurita; Jun Nakayama; Nobuo Okumura; Sachie Hiratsuka
Nature communications, 14(1), 4960-4960, Aug. 2023

Extracellular mRNA transported to the nucleus exerts translation-independent function
Takeshi Tomita; Masayoshi Kato; Taishi Mishima; Yuta Matsunaga; Hideki Sanjo; Ken-ichi Ito; Kentaro Minagawa; Toshimitsu Matsui; Hiroyuki Oikawa; Satoshi Takahashi; Toshifumi Takao; Noriki Iwai; Takashi Mino; Osamu Takeuchi; Yoshiro Maru; Sachie Hiratsuka
Nature Communications, 12(1), Dec. 2021

Regulation of vascular permeability in cancer metastasis
Takeshi Tomita; Masayoshi Kato; Sachie Hiratsuka
Cancer Science, Jun. 2021

Analysis of ADAM12-Mediated Ephrin-A1 Cleavage and Its Biological Functions
Katsuaki Ieguchi; Takeshi Tomita; Toshifumi Takao; Tsutomu Omori; Taishi Mishima; Isao Shimizu; Massimiliano Tognolini; Alessio Lodola; Takuya Tsunoda; Shinichi Kobayashi; Satoshi Wada; Yoshiro Maru
International Journal of Molecular Sciences, 22(5), 2480-2480, Mar. 2021

Lung Tumor Cell Recruitment Assay.
Tomita T; Ieguchi K; Deguchi A; Takita M; Tsukahara F; Hiratsuka S; Maru Y
Journal of visualized experiments : JoVE, (144), Feb. 2019, Refereed, Not invited

紫外線照射によって誘導されるヌクレオチド除去修復におけるC1Dの細胞内局在
家口 勝昭; 富田 毅; 瀧田 守親; 出口 敦子; 平塚 佐千枝; 三島 大志; 丸 義朗
東京女子医科大学総合研究所紀要, 38, 20-21, Jan. 2019

A novel pathway of LPS uptake through syndecan-1 leading to pyroptotic cell death.
Yokoyama S; Cai Y; Murata M; Tomita T; Yoneda M; Xu L; Pilon AL; Cachau RE; Kimura S
eLife, 7, Dec. 2018, Refereed, Not invited

C1D is not directly involved in the repair of UV-damaged DNA but protects cells from oxidative stress by regulating gene expressions in human cell lines.
Tomita T; Ieguchi K; Takita M; Tsukahara F; Yamada M; Egly JM; Maru Y
The journal of biochemistry, Aug. 2018, Refereed, Not invited

Hepato-entrained B220+CD11c+NK1.1+ cells regulate pre-metastatic niche formation in the lung.
Sachie Hiratsuka; Takeshi Tomita; Taishi Mishima; Yuta Matsunaga; Tsutomu Omori; Sachie Ishibashi; Satoshi Yamaguchi; Tsuyoshi Hosogane; Hiroshi Watarai; Miyuki Omori-Miyake; Tomoko Yamamoto; Noriyuki Shibata; Akira Watanabe; Hiroyuki Aburatani; Michio Tomura; Katherine A High; Yoshiro Maru
EMBO molecular medicine, 10(7), Jul. 2018, Refereed, Not invited

マウスの肺組織内における神経網の観察
家口 勝昭; 平塚 佐千枝; 富田 毅; 出口 敦子; 瀧田 守親; 三島 大志; 丸 義朗
東京女子医科大学総合研究所紀要, 37, 42-43, Mar. 2018

Eritoran inhibits S100A8-mediated TLR4/MD-2 activation and tumor growth by changing the immune microenvironment
A. Deguchi; T. Tomita; U. Ohto; K. Takemura; A. Kitao; S. Akashi-Takamura; K. Miyake; Y. Maru
ONCOGENE, 35(11), 1445-1456, Mar. 2016, Refereed, Not invited

Correction: ZFC3H1, a Zinc Finger Protein, Modulates IL-8 Transcription by Binding with Celastramycin A, a Potential Immune Suppressor.
Tomita T; Ieguchi K; Coin F; Kato Y; Kikuchi H; Oshima Y; Kurata S; Maru Y
PloS one, 10(9), e0138262, Sep. 2015, Refereed, Not invited

Transgenically-expressed secretoglobin 3A2 accelerates resolution of bleomycin-induced pulmonary fibrosis in mice
Yan Cai; Mitsuhiro Yoneda; Takeshi Tomita; Reiko Kurotani; Minoru Okamoto; Taketomo Kido; Hiroyuki Abe; Wayne Mitzner; Arjun Guha; Shioko Kimura
BMC PULMONARY MEDICINE, 15, 72, Jul. 2015, Refereed, Not invited

Human Serum Amyloid A3 (SAA3) Protein, Expressed as a Fusion Protein with SAA2, Binds the Oxidized Low Density Lipoprotein Receptor
Takeshi Tomita; Katsuaki Ieguchi; Tatsuya Sawamura; Yoshiro Maru
PLOS ONE, 10(3), e0118835, Mar. 2015, Refereed, Not invited

Drug Targeting Based on a New Concept-Targeting Against TLR4 as an Example
Yoshiro Maru; Takeshi Tomita; Atsuko Deguchi; Katsuaki Ieguchi; Morichika Takita; Fujiko Tsukahara; Kazuhiro Takemura; Akio Kitao; Fabian Gusovsky
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS, 15(2), 83-87, 2015, Refereed, Not invited

ZFC3H1, a Zinc Finger Protein, Modulates IL-8 Transcription by Binding with Celastramycin A, a Potential Immune Suppressor
Takeshi Tomita; Katsuaki Ieguchi; Fredric Coin; Yasuhiro Kato; Haruhisa Kikuchi; Yoshiteru Oshima; Shoichiro Kurata; Yoshiro Maru
PLOS ONE, 9(9), e108957, Sep. 2014, Refereed, Not invited

ADAM12-cleaved ephrin-A1 contributes to lung metastasis
K. Ieguchi; T. Tomita; T. Omori; A. Komatsu; A. Deguchi; J. Masuda; S. L. Duffy; M. G. Coulthard; A. Boyd; Y. Maru
ONCOGENE, 33(17), 2179-2190, Apr. 2014, Refereed, Not invited

Ephrin-A1 expression induced by S100A8 is mediated by the toll-like receptor 4
Katsuaki Ieguchi; Tsutomu Omori; Akiko Komatsu; Takeshi Tomita; Atsuko Deguchi; Yoshiro Maru
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 440(4), 623-629, Nov. 2013, Refereed, Not invited

Serum amyloid A3 binds MD-2 to activate p38 and NF-κB pathways in a MyD88-dependent manner
Atsuko Deguchi; Takeshi Tomita; Tsutomu Omori; Akiko Komatsu; Umeharu Ohto; Satoshi Takahashi; Natsuko Tanimura; Sachiko Akashi-Takamura; Kensuke Miyake; Yoshiro Maru
Journal of Immunology, 191(4), 1856-1864, Aug. 2013, Refereed, Not invited

Primary tumours modulate innate immune signalling to create pre-metastatic vascular hyperpermeability foci
Sachie Hiratsuka; Sachie Ishibashi; Takeshi Tomita; Akira Watanabe; Sachiko Akashi-Takamura; Masato Murakami; Hiroshi Kijima; Kensuke Miyake; Hiroyuki Aburatani; Yoshiro Maru
Nature Communications, 4, 1853, 2013, Refereed, Not invited

細胞接着におけるEphA1受容体の機能解析
家口 勝昭; 富田 毅; 出口 敦子; 平塚 佐千枝; 丸 義朗
東京女子医科大学総合研究所紀要, 32, 36-37, Aug. 2012

Imbalance of Clara cell-mediated homeostatic inflammation is involved in lung metastasis
T. Tomita; Y. Sakurai; S. Ishibashi; Y. Maru
ONCOGENE, 30(31), 3429-3439, Aug. 2011, Refereed, Not invited

Secretoglobin 3A2 Suppresses Bleomycin-induced Pulmonary Fibrosis by Transforming Growth Factor beta Signaling Down-regulation
Reiko Kurotani; Satoshi Okumura; Tsutomu Matsubara; Utako Yokoyama; John R. Buckley; Takeshi Tomita; Kyohei Kezuka; Tomokazu Nagano; Dominic Esposito; Troy E. Taylor; William K. Gillette; Yoshihiro Ishikawa; Hiroyuki Abe; Jerrold M. Ward; Shioko Kimura
JOURNAL OF BIOLOGICAL CHEMISTRY, 286(22), 19682-19692, Jun. 2011, Refereed, Not invited

FOXA1 plays a role in regulating secretoglobin 1a1 expression in the absence of CCAAT/enhancer binding protein activities in lung in vivo
Taketomo Kido; Takeshi Tomita; Minoru Okamoto; Yan Cai; Yoshimi Matsumoto; Charles Vinson; Yoshiro Maru; Shioko Kimura
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 300(3), 441-452, Mar. 2011, Refereed, Not invited

Oncostatin M Regulates Secretoglobin 3A1 and 3A2 Expression in a Bidirectional Manner
Takeshi Tomita; Atsushi Yamada; Masaaki Miyakoshi; Taketomo Kido; Faruk Sheikh; Achara Srisodsai; Atsushi Miyajima; Raymond P. Donnelly; Shioko Kimura
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 40(5), 620-630, May 2009, Refereed, Not invited

CAATT/enhancer-binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression
Takeshi Tomita; Taketomo Kido; Reiko Kurotani; Shun-ichiro Iemura; Esta Sterneck; Tohru Natsume; Charles Vinson; Shioko Kimura
JOURNAL OF BIOLOGICAL CHEMISTRY, 283(37), 25617-25627, Sep. 2008, Refereed, Not invited

Role of secretoglobin 3A2 in lung development
Reiko Kurotani; Takeshi Tomita; Qian Yang; Bradley A. Carlson; Chi Chen; Shioko Kimura
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 178(4), 389-398, Aug. 2008, Refereed, Not invited

Regulation of mouse Scgb3a1 gene expression by NF-Y and association of CpG methylation with its tissue-specific expression
Takeshi Tomita; Shioko Kimura
BMC MOLECULAR BIOLOGY, 9, 5, Jan. 2008, Refereed, Not invited

Bach1, a heme-dependent transcription factor, reveals presence of multiple heme binding sites with distinct coordination structure
Shusuke Hira; Takeshi Tomita; Toshitaka Matsui; Kazuhiko Igarashi; Masao Ikeda-Saito
IUBMB LIFE, 59(8-9), 542-551, 2007, Refereed, Not invited

Roles of distal asp in heme oxygenase from Corynebacterium diphtheriae, HmuO - A water-driven oxygen activation mechanism
T Matsui; M Furukawa; M Unno; T Tomita; M Ikeda-Saito
JOURNAL OF BIOLOGICAL CHEMISTRY, 280(4), 2981-2989, Jan. 2005, Refereed, Not invited

Regulation of Drosophila hypoxia-inducible factor (HIF) activity in SL2 cells - Identification of a hypoxia-induced variant isoform of the HIF alpha homolog gene similar
TA Gorr; T Tomita; P Wappner; HF Bunn
JOURNAL OF BIOLOGICAL CHEMISTRY, 279(34), 36048-36058, Aug. 2004, Refereed, Not invited

Spectroscopic characterization of five- and six-coordinate ferrous-NO heme complexes. Evidence for heme Fe-proximal cysteinate bond cleavage in the ferrous-NO adducts of the Trp-409Tyr/Phe proximal environment mutants of neuronal nitric oxide synthase
HL Voegtle; M Sono; S Adak; AE Pond; T Tomita; R Perera; DB Goodin; M Ikeda-Saito; DJ Stuehr; JH Dawson
BIOCHEMISTRY, 42(8), 2475-2484, Mar. 2003, Refereed, Not invited

Resonance Raman studies on xanthine oxidase: observation of Mo-VI-ligand vibrations
NC Maiti; T Tomita; T Kitagawa; K Okamoto; T Nishino
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 8(3), 327-333, Feb. 2003, Refereed, Not invited

転写制御因子Bach1のヘム配位構造
平 就介; 富田 毅; 五十嵐 和彦; 齋藤 正男
生化学, 74(8), 1002-1002, Aug. 2002

Nature of the displaceable heme-axial residue in the EcDos protein, a heme-based sensor from Escherichia coli
G Gonzalez; EM Dioum; CM Bertolucci; T Tomita; M Ikeda-Saito; MR Cheesman; NJ Watmough; MA Gilles-Gonzalez
BIOCHEMISTRY, 41(26), 8414-8421, Jul. 2002, Refereed, Not invited

A comparative resonance Raman analysis of heme-binding PAS domains: Heme iron coordination structures of the BjFixL, AxPDEA1, EcDos, and MtDos proteins
T Tomita; G Gonzalez; AL Chang; M Ikeda-Saito; MA Gilles-Gonzalez
BIOCHEMISTRY, 41(15), 4819-4826, Apr. 2002, Refereed, Not invited

Elucidation of the differences between the 430-and 455-nm absorbing forms of P450-isocyanide adducts by resonance Raman spectroscopy
T Tomita; S Ogo; T Egawa; H Shimada; N Okamoto; Y Imai; Y Watanabe; Y Ishimura; T Kitagawa
JOURNAL OF BIOLOGICAL CHEMISTRY, 276(39), 36261-36267, Sep. 2001, Refereed, Not invited

A role for highly conserved carboxylate, aspartate-140, in oxygen activation and heme degradation by heme oxygenase-1
H Fujii; XH Zhang; T Tomita; M Ikeda-Saito; T Yoshida
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 123(27), 6475-6484, Jul. 2001, Refereed, Not invited

UV resonance Raman detection of a ligand vibration on ferric nitrosyl heme proteins
T Tomita; N Haruta; M Aki; T Kitagawa; M Ikeda-Saito
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 123(11), 2666-2667, Mar. 2001, Refereed, Not invited

Histidine 20, the crucial proximal axial heme ligand of bacterial heme oxygenase Hmu O from Corynebacterium diphtheriae
GC Chu; K Katakura; T Tomita; XH Zhang; DY Sun; M Sato; M Sasahara; T Kayama; M Ikeda-Saito; T Yoshida
JOURNAL OF BIOLOGICAL CHEMISTRY, 275(23), 17494-17500, Jun. 2000, Refereed, Not invited

The heme complex of Hmu O, a bacterial heme degradation enzyme from Corynebacterium diphtheriae - Structure of the catalytic site
GC Chu; T Tomita; FD Sonnichsen; T Yoshida; M Ikeda-Saito
JOURNAL OF BIOLOGICAL CHEMISTRY, 274(35), 24490-24496, Aug. 1999, Refereed, Not invited

Resonance Raman investigation of Fe-N-O structure of nitrosylheme in myoglobin and its mutants
T Tomita; S Hirota; T Ogura; JS Olson; T Kitagawa
JOURNAL OF PHYSICAL CHEMISTRY B, 103(33), 7044-7054, Aug. 1999, Refereed, Not invited

Characterization of a novel monoclonal antibody that senses nitric oxide-dependent activation of soluble guanylate cyclase
S Tsuyama; E Yamazaki; T Tomita; H Ihara; S Takenaka; K Kato; S Kozaki
FEBS LETTERS, 455(3), 291-294, Jul. 1999, Refereed, Not invited

Purification of bovine soluble guanylate cyclase and ADP-ribosylation on its small subunit by bacterial toxins
T Tomita; S Tsuyama; Y Imai; T Kitagawa
JOURNAL OF BIOCHEMISTRY, 122(3), 531-536, Sep. 1997, Refereed, Not invited

Effects of GTP on bound nitric oxide of soluble guanylate cyclase probed by resonance Raman spectroscopy
T Tomita; T Ogura; S Tsuyama; Y Imai; T Kitagawa
BIOCHEMISTRY, 36(33), 10155-10160, Aug. 1997, Refereed, Not invited

Resonance Raman studies of bovine soluble guanylate cyclase
T Kitagawa; T Tomita; T Ogura; S Tsuyama; Y Imai
SPECTROSCOPY OF BIOLOGICAL MOLECULES: MODERN TRENDS, 177-178, 1997, Refereed, Not invited

Highly Acidic Extractant, 4-Benzoyl-3-phenyl-5-isoxazolone: The Synergistic Extraction of Alkaline Earth and Alkali Metals Combined with Trioctylphosphine Oxide or Bis(diphenylphosphinyl)methane
Quyen TH Le; Umetani S; Sasaki T; Tomita T; Matsui M
Bulletin of the chemical society of japan, 68(10), 2867-2873, Jan. 1995, Refereed, Not invited

Biological function of extracellular mRNA
富田毅; 富田毅; 平塚佐千枝; 平塚佐千枝
生化学, 94(5), 2022

TLR4/MD-2 ligands promote metastasis
富田 毅; 丸 義朗
Thrombosis Medicine, 8(2), 117 - 121, Jun. 2018, Invited

マウスの肺組織内における神経網の観察
家口 勝昭; 平塚 佐千枝; 富田 毅; 出口 敦子; 瀧田 守親; 三島 大志; 丸 義朗
東京女子医科大学総合研究所紀要, 37, 42 - 43, Mar. 2018, Not invited

肺がんへの転移とS100A8
富田 毅; 丸 義朗
生体の科学, 67(5), 460 - 461, Oct. 2016, Invited

TLR4/MD-2の蛋白質内因性リガンドと癌転移の分子基盤
富田 毅; 丸 義朗
医学のあゆみ, 253(11), 1099 - 1103, Jun. 2015, Invited

臓器連関とがん転移前土壌形成
富田 毅; 丸 義朗
細胞工学, 33(5), 508 - 511, May 2014, Invited

最近のヘムタンパク質研究
富田 毅; 齋藤正男
生化学, 75(5), 577 - 587, May 2003, Invited

細胞外RNAによる抗転移細胞活性化の解明
科学研究費助成事業, 日本学術振興会, 基盤研究(B)
信州大学
01 Apr. 2022 - 31 Mar. 2025

抗転移細胞で特異的に発現するタンパク質の分子機序解明
科学研究費助成事業, 日本学術振興会, 基盤研究(C)
信州大学
01 Apr. 2020 - 31 Mar. 2023

Anti-metastatic cells in tumor-stimulated organs
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
Shinshu University
01 Apr. 2019 - 31 Mar. 2022

Biochemical characterization of an inflammation related protein, mTOC (Celastramycin binding protein)
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
01 Apr. 2017 - 31 Mar. 2020

Serum amyloid A3 and intracellular signaling protein mTOC
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Tokyo Women's Medical University
01 Apr. 2014 - 31 Mar. 2017

Roles of oxidized LDL receptor and TLR4 signaling in lung metastasis
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Tokyo Women's Medical University
2011 - 2013

Endogenous TLR4 ligands in tumor metastasis.
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Tokyo Women's Medical University
23 Jul. 2009 - 31 Mar. 2014

Molecular mechanism of serum amyloid signaling in lung metastasis
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B)
Tokyo Women's Medical University
2009 - 2010

二原子分子受容体の作用メカニズム
科学研究費助成事業, 日本学術振興会, 若手研究(B)
東北大学
2002 - 2003

Following Heme Oxygenase Reaction at Atomic Scale
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
Tohoku University
2002 - 2003

NO-cGMP系情報伝達システムの分子機構
科学研究費助成事業, 日本学術振興会, 特定領域研究
東北大学
2000 - 2004

Structure and Function of heme related proteins involved in intracellular signal transduction
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
TOHOKU UNIVERSITY
2000 - 2001

Structure-Function coorelations in Zinc finger proteins