OHKANDA Junko
Academic Assembly School of Science and Technology Institute of Agriculture
Faculty of Agriculture Department of Agricultural and Life Sciences Division of Bioscience and Biotechnology
Professor
Research Keyword
- protein-protein interactions, 14-3-3 proteins, Antitumor agents, fusicoccin, intrinsically disordered proteins and regions, Natural products, Peptides, Pharmaceutical and plant hormones, Posttranslational modification, Signaling pathways
Mail Address
- johkanda★shinshu-u.ac.jp
Career
- 2022
Chemistry A European Journal, Editorial board member (Wiley-VCH) - 2017
Bioorganic Chemistry Editorial board member (Elsevier) - 2016
Professor, Shinshu University - 2013 - 2016
Associate Professor, ICR, Kyoto University - 2005 - 2013
Associate Professor, ISIR, Osaka University - 2004 - 2005
Lecturer, Tokyo Gakugei University - 2003 - 2003
Researcher, Achillion Pharmaceuticals, Inc. (Connecticut, USA) - 1998 - 2003
Postdoctral Associate, Department of Chemistry, Yale University - 1991 - 1997
Assistant Professor, Seikei University - 1990 - 1991
Researcher, Ricoh Co. Ltd.
View All
Paper
- Functional evaluation of an electrophilic focused library to identify a covalent inhibitor against intrinsically disordered circadian clock transcription factors
Kazuya Yamanaka, Yoshihisa Inoue, Miki Imanishi, Junko Ohkanda
Bioorganic & Medicinal Chemistry Letters, 98, Jan. 2024, Refereed
- Isoform-selective fluorescent labeling of 14-3-3sigma by acrylamide-containing fusicoccins
Kenta Tanaka, Yoshiya Hatano, Junko Ohkanda
Chemistry A European Journal, 29(41), Jul. 2023, Refereed - Structure-activity-relationship study of semi-synthetically modified fusicoccins on their stabilization effect for 14-3-3 phoospholigand interactions
Nanami Ogino, Ryoma Masuda, LouvyLynn Punzalan, Emi Yamashita, Shota Igaue, Yoshihisa Inoue, Junko Ohkanda
Bioorg. Med. Chem., 73, 117020, 18 Sep. 2022 - Expression and purification of DYRK1A kinase domain in complex with its folding intermediate-selective inhibitor FINDY
Ninako Kimura, Kanako Saito, Takashi Niwa, Masato Yamakawa, Shota Igaue, Junko Ohkanda, Takamitsu Hosoya, Isao Kii
Protein Expr. Purif., 196-196, 106089, 18 Mar. 2022 - Design, synthesis, and functional evaluation of triazine-based bivalent agents that simultaneously target the active site and hot spot of phosphatase Cdc25B
Yosei Nagaoka, Prakash Parvatkar, Go Hirai, Junko Ohkanda
Bioorg. Med. Chem. Lett., 48, 128265, 12 Jul. 2021 - Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets
Hosoya, Yusuke; Ohkanda, Junko;
MOLECULES, 26(8), Apr. 2021
- Fusicoccin: A Chemical Modulator for 14-3-3 Proteins
Ohkanda, Junko;
Chemistry Letters, 50(1), 57-67, Jan. 2021 - Identification of synthetic inhibitors for the DNA binding of intrinsically disordered circadian clock transcription factors
Yusuke Hosoya, Wataru Nojo, Isao Kii, Takanori Suzuki, Miki Imanishi, Junko Ohkanda
Chemical Communications, 56, 11203-11206, 21 Aug. 2020, Refereed - Copper-Free Huisgen Cycloaddition for the 14-3-3-Templated Synthesis of Fusicoccin-Peptide Conjugates
Masuda, Ryoma; Kawasaki, Yuuya; Igawa, Kazunobu; Manabe, Yoshiyuki; Fujii, Hiroshi; Kato, Nobuo; Tomooka, Katsuhiko; Ohkanda, Junko;
CHEMISTRY-AN ASIAN JOURNAL, 15, 742-747, 2020
- A NOVEL CONDENSED HETEROCYCLIC QUINONE WITH A DIBENZOFURANOBISTHIADIAZOLE SKELETON
Sugawara, Kazuma; Nojo, Wataru; Ishigaki, Yusuke; Ohkanda, Junko; Suzuki, Takanori;
Heterocycles, 101(1), 99-103, 2020 - Dipicolylamine/Metal Complexes that Promote Direct Cell-Membrane Penetration of Octaarginine
Kawaguchi, Yoshimasa; Ise, Shoko; Azuma, Yusuke; Takeuchi, Toshihide; Kawano, Kenichi; Toan Khanh Le; Ohkanda, Junko; Futaki, Shiroh;
Bioconjugate chemistry, 30(2), 454-460, Feb. 2019 - A Guanidyl-Based Bivalent Peptidomimetic Inhibits K-Ras Prenylation and Association with c-Raf
Tsubamoto, Mai; Toan Khanh Le; Li, Minghua; Watanabe, Taku; Matsumi, Chiemi; Parvatkar, Prakash; Fujii, Hiroshi; Kato, Nobuo; Sun, Jiazhi; Ohkanda, Junko;
CHEMISTRY-A EUROPEAN JOURNAL, 25(59), 13531-13536, 2019 - Structural Effects of Fusicoccin upon Upregulation of 14-3-3-Phospholigand Interaction and Cytotoxic Activity
Ohkanda, Junko; Kusumoto, Atsushi; Punzalan, Louvy; Masuda, Ryoma; Wang, Chenyu; Parvatkar, Prakash; Akase, Dai; Aida, Misako; Uesugi, Motonari; Higuchi, Yusuke; Kato, Nobuo;
CHEMISTRY-A EUROPEAN JOURNAL, 24(60), 16066-16071, 2018 - A Strategy of Designing Mid-sized Synthetic Molecules that Recognize Interfaces of Protein protein Interactions
Ohkanda, Junko;
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 75(7), 735-745, Jul. 2017 - たんぱく質間相互作用を制御する合成分子の創製
大神田 淳子;
京都大学化学研究所スーパーコンピュータシステム研究成果報告書, 2016, 7-7, Mar. 2017 - Protein-guided self-assembly for controlling protein-protein interactions
Junko Ohkanda
Journal of the Society of Japanese Women Scientists, 17, 1-7, 2017 - Intracellular Generation of a Diterpene-Peptide Conjugate that Inhibits 14-3-3-Mediated Interactions
Parvatkar, Prakash; Kato, Nobuo; Uesugi, Motonari; Sato, Shin-ichi; Ohkanda, Junko;*
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 137(50), 15624-15627, 2015 - RNA-Directed Amino Acid Coupling as a Model Reaction for Primitive Coded Translation
Harada, Kazuo*; Aoyama, Shoko; Matsugami, Akimasa; Kumar, Penmetcha K. R.; Katahira, Masato; Kato, Nobuo; Ohkanda, Junko;
ChemBioChem, 15(6), 794-798, 2014 - Module Assembly for Designing Multivalent Mid-Sized Inhibitors of Protein-Protein Interactions
Ohkanda, Junko;*
CHEMICAL RECORD, 13(6), 561-575, Dec. 2013 - Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers
Molzan, Manuela; Kasper, Stefan; Roeglin, Lars; Skwarczynska, Malgorzata; Sassa, Takeshi; Inoue, Takatsugu; Breitenbuecher, Frank; Ohkanda, Junko; Kato, Nobuo; Schuler, Martin; Ottmann, Christian;
ACS Chemical Biology, 8(9), 1869-1875, Sep. 2013 - Peptidomimetic modification improves cell permeation of bivalent farnesyltransferase inhibitors
Machida, Shinnosuke; Tsubamoto, Mai; Kato, Nobuo; Harada, Kazuo; Ohkanda, Junko;
Bioorganic & medicinal chemistry, 21(14), 4004-4010, 2013 - A Semisynthetic Fusicoccane Stabilizes a Protein-Protein Interaction and Enhances the Expression of K+ Channels at the Cell Surface
Anders, Carolin; Higuchi, Yusuke; Koschinsky, Kristin; Bartel, Maria; Schumacher, Benjamin; Thiel, Philipp; Nitta, Hajime; Preisig-Mueller, Regina; Schlichthoerl, Guenter; Renigunta, Vijay; Ohkanda, Junko; Daut, Juergen; Kato, Nobuo; Ottmann, Christian;
CHEMISTRY & BIOLOGY, 20(4), 583-593, 2013 - Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-D-xylulose 5-phosphate synthase
Hayashi, Daisuke; Kato, Nobuo; Kuzuyama, Tomohisa; Sato, Yasuo; Ohkanda, Junko;*
Chemical Communications, 49(49), 5535-5537, 2013 - Chemical ligation of epoxide-containing fusicoccins and peptide fragments guided by 14-3-3 protein
Maki, Toshio; Kawamura, Akie; Kato, Nobuo; Ohkanda, Junko;*
MOLECULAR BIOSYSTEMS, 9(5), 940-943, 2013 - A Novel Fusicoccin Derivative Preferentially Targets Hypoxic Tumor Cells and Inhibits Tumor Growth in Xenografts
Kawakami, Koshi; Hattori, Miho; Inoue, Takatsugu; Maruyama, Yuriko; Ohkanda, Junko; Kato, Nobuo; Tongu, Miki; Yamada, Takaya; Akimoto, Miho; Takenaga, Keizo; Sassa, Takeshi; Suzumiy, Junji; Honma, Yoshio;
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 12(7), 791-800, Sep. 2012 - Protein recognition of hetero-/homoleptic ruthenium(II) tris(bipyridine)s for alpha-chymotrypsin and cytochrome c
Yamaguchi, Yoshinobu; Kato, Nobuo; Azuma, Hideki; Nagasaki, Takeshi; Ohkanda, Junko;*
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22(6), 2354-2358, 2012 - Phosphopeptide-Dependent Labeling of 14-3-3 zeta Proteins by Fusicoccin-Based Fluorescent Probes
Takahashi, Michiko; Kawamura, Akie; Kato, Nobuo; Nishi, Tsuyoshi; Hamachi, Itaru; Ohkanda, Junko;*
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 51(2), 509-512, 2012 - Bivalent Inhibitors for Disrupting Protein Surface-Substrate Interactions and for Dual Inhibition of Protein Prenyltransferases
Machida, Shinnosuke; Kato, Nobuo; Harada, Kazuo; Ohkanda, Junko;*
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 133(4), 958-963, 2011 - Design and functional evaluation of dual prenyltransferase inhibitors for simultaneous recognition of active site and exterior protein surface
Machida, Shinnosuke; Kato, Nobuo; Harada, Kazuo; Ohkanda, Junko;
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 238, 2009 - Transannular Proton Transfer in the Cyclization of Geranylgeranyl Diphosphate to Fusicoccadiene, a Biosynthetic Intermediate of Fusicoccins
Toyomasu, Tomonobu; Tsukahara, Mai; Kenmoku, Hiromichi; Anada, Masahide; Nitta, Hajime; Ohkanda, Junko; Mitsuhashi, Wataru; Sassa, Takeshi; Kato, Nobuo;
ORGANIC LETTERS, 11(14), 3044-3047, 2009 - Structurally Simple Inhibitors of Lanosterol 14 alpha-Demethylase Are Efficacious In a Rodent Model of Acute Chagas Disease
Suryadevara, Praveen Kumar; Olepu, Srinivas; Lockman, Jeffrey W.; Ohkanda, Junko; Karimi, Mandana; Verlinde, Christophe L. M. J.; Kraus, James M.; Schoepe, Jan; Van Voorhis, Wesley C.; Hamilton, Andrew D.; Buckner, Frederick S.; Gelb, Michael H.;
JOURNAL OF MEDICINAL CHEMISTRY, 52(12), 3703-3715, 2009 - Protein surface recognition by dendritic ruthenium(II) tris(bipyridine) complexes
Ohkanda, Junko; Satoh, Ritsuko; Kato, Nobuo;
Chemical Communications, (45), 6949-6951, 2009 - Module assembly for protein-surface recognition: Geranylgeranyltransferase I bivalent inhibitors for simultaneous targeting of interior and exterior protein surfaces
Machida, Shinnosuke; Usuba, Kakeru; Blaskovich, Michelle A.; Yano, Akiko; Harada, Kazuo; Sebti, Said M.; Kato, Nobuo; Ohkanda, Junko;
CHEMISTRY-A EUROPEAN JOURNAL, 14(5), 1392-1401, 2008 - Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter
Delarue, F. L.; Adnane, J.; Joshi, B.; Blaskovich, M. A.; Wang, D-A; Hawker, J.; Bizouarn, F.; Ohkanda, J.; Zhu, K.; Hamilton, A. D.; Chellappan, S.; Sebti, S. M.;
Oncogene, 26(5), 633-640, Feb. 2007 - ORGN 129-Bivalent inhibitors of Type-I geranylgeranyltransferase for simultaneous recognition of interior and exterior protein surfaces
Ohkanda, Junko; Machida, Shinnosuke; Kato, Nobuo; Blaskovich, Michelle A.; Sebti, Saied M.; Harada, Kazuo;
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 234, 2007 - Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase
Ohkanda, J; Strickland, CL; Blaskovich, MA; Carrico, D; Lockman, JW; Vogt, A; Bucher, CJ; Sun, JZ; Qian, YM; Knowles, D; Pusateri, EE; Sebti, SM; Hamilton, AD;
Organic & Biomolecular Chemistry, 4(3), 482-492, 2006 - In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability
Carrico, D; Ohkanda, J; Kendrick, H; Yokoyama, K; Blaskovich, MA; Bucher, CJ; Buckner, FS; Van Voorhis, WC; Chakrabarti, D; Croft, SL; Gelb, MH; Sebti, SM; Hamilton, AD;
Bioorganic & medicinal chemistry, 12(24), 6517-6526, 2004 - Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents
Ohkanda, J; Buckner, FS; Lockman, JW; Yokoyama, K; Carrico, D; Eastman, R; de Luca-Fradley, K; Davies, W; Croft, SL; Van Voorhis, WC; Gelb, MH; Sebti, SM; Hamilton, AD;
JOURNAL OF MEDICINAL CHEMISTRY, 47(2), 432-445, 2004 - In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus
Bordier, BB; Ohkanda, J; Liu, P; Lee, SY; Salazar, FH; Marion, PL; Ohashi, K; Meuse, L; Kay, MA; Casey, JL; Sebti, SM; Hamilton, AD; Glenn, JS;
JOURNAL OF CLINICAL INVESTIGATION, 112(3), 407-414, Aug. 2003 - The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells
Bolick, SCE; Landowski, TH; Boulware, D; Oshiro, MM; Ohkanda, J; Hamilton, AD; Sebti, SM; Dalton, WS;
Leukemia, 17(2), 451-457, Feb. 2003 - Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice
Sun, JZ; Ohkanda, J; Coppola, D; Yin, H; Kothare, M; Busciglio, B; Hamilton, AD; Sebti, SM;
CANCER RESEARCH, 63(24), 8922-8929, 2003 - A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents
Buckner, F; Yokoyama, K; Lockman, J; Aikenhead, K; Ohkanda, J; Sadilek, M; Sebti, S; Van Voorhis, W; Hamilton, A; Gelb, MH;
Proceedings of the National Academy of Sciences of the United States of America, 100(25), 15149-15153, 2003 - The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status
Crespo, NC; Delarue, F; Ohkanda, J; Carrico, D; Hamilton, AD; Sebti, SM;
CELL DEATH AND DIFFERENTIATION, 9(7), 702-709, Jul. 2002 - CAAX peptidomimetics: Their farnesyltransferase inhibition activity and antitumor effect
Ohkanda, J;
SEIKAGAKU, 74(1), 46-50, Jan. 2002 - Synthesis of linear and cyclic hexapeptides with N epsilon-(1,2-dihydro-1-hydroxy-2-oxopyrimidin-4-yl)-L-lysyl-beta-alanyl as the repeating unit and properties of their iron(III) complexes
Katoh, A; Inoue, Y; Nagashima, H; Hikita, Y; Ohkanda, J; Saito, R;
Heterocycles, 58, 371-381, 2002 - Toward Chagas disease chemotherapeutics: Development of simple compounds active against Trypanosoma cruzi.
Lockman, JW; Ohkanda, J; Yokoyama, K; Eastman, RT; Buckner, FS; Gelb, MH; Hamilton, AD;
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 224, U17-U17, 2002 - Design, synthesis and evaluation of peptidomimetic farnesyltransferase inhibitor ester pro-drugs as potent antiparasitic agents.
Carrico, D; Ohkanda, J; Gelb, MH; Blaskovich, MA; Sebti, SM; Hamilton, AD;
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 224, U28-U28, 2002 - Prenyltransferase inhibitors as antitumor and antiparasitic agents: Rational design based on CAAX peptide and solution phase combinatorial approaches.
Ohkanda, J; Lockman, JW; Carrico, D; Strickland, CL; Sebti, SM; Gelb, MH; Hamilton, AD;
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 224, U30-U30, 2002 - Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold
Ohkanda, J; Lockman, JW; Kothare, MA; Qian, YM; Blaskovich, MA; Sebti, SM; Hamilton, AD;
JOURNAL OF MEDICINAL CHEMISTRY, 45(1), 177-188, 2002 - 3-hydroxy-4(1H)-pyridinone-containing linear and cyclic hexapeptides and their iron(III) complexes - Synthesis, property, and the growth-promotion activity-
Katoh, A; Hikita, Y; Harata, M; Ohkanda, J; Tsubomura, T; Higuchi, A; Saito, R; Harada, K;
Heterocycles, 55(11), 2171-2187, 2001 - The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells
Crespo, NC; Ohkanda, J; Yen, TJ; Hamilton, AD; Sebti, SM;
JOURNAL OF BIOLOGICAL CHEMISTRY, 276(19), 16161-16167, 2001 - Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity
Ohkanda, J; Lockman, JW; Yokoyama, K; Gelb, MH; Croft, SL; Kendrick, H; Harrell, MI; Feagin, JE; Blaskovich, MA; Sebti, SM; Hamilton, AD;
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 11(6), 761-764, 2001 - Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
Lantry, LE; Zhang, ZQ; Yao, RS; Crist, KA; Wang, Y; Ohkanda, J; Hamilton, AD; Sebti, SM; Lubet, RA; You, M;
CARCINOGENESIS, 21(1), 113-116, Jan. 2000 - Development of a tripeptide mimetic strategy for the inhibition of protein farnesyltransferase
Kothare, MA; Ohkanda, J; Lockman, JW; Qian, YM; Blaskovich, MA; Sebti, SM; Hamilton, AD;
Tetrahedron, 56(50), 9833-9841, 2000 - Inhibition of farnesyltransferase increases TGF beta type II receptor expression and enhances the responsiveness of human cancer cells to TGF beta
Adnane, J; Bizouarn, FA; Chen, Z; Ohkanda, J; Hamilton, AD; Munoz-Antonia, T; Sebti, SM;
Oncogene, 19(48), 5525-5533, 2000 - Synthesis of quinoxaline derivatives bearing the styryl and phenylethynyl groups and application to a fluorescence derivatization reagent
Katoh, A; Yoshida, T; Ohkanda, J;
Heterocycles, 52(2), 911-920, 2000 - Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: Combination therapy with the cytotoxic agents cisplatin, taxol, and gemcitabine
Sun, JZ; Blaskovich, MA; Knowles, D; Qian, YM; Ohkanda, J; Bailey, RD; Hamilton, AD; Sebti, SM;
CANCER RESEARCH, 59(19), 4919-4926, 1999 - Novel nonthiol inhibitors of farnesyl transferase show potent antitumor properties.
Ohkanda, J; Blaskovich, M; Sun, J; Sebti, SM; Hamilton, AD;
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 218, U984-U984, 1999 - Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I
Vasudevan, A; Qian, YM; Vogt, A; Blaskovich, MA; Ohkanda, J; Sebti, SM; Hamilton, AD;
JOURNAL OF MEDICINAL CHEMISTRY, 42(8), 1333-1340, 1999 - Synthesis of 6-(bromoacetyl)amino-2,3-dimorpholinoquinoxaline and application to a new fluorescence derivatization reagent of fatty acids for the high-performance liquid chromatographic analysis
Katoh, A; Fujimoto, T; Takahashi, M; Ohkanda, J;
Heterocycles, 50(1), 299-308, 1999 - Synthesis of 2,2 '-bipyridines bearing amino or carboxyl group at the side chain and physical properties of their ruthenium(II) complexes
Katoh, A; Kitamura, Y; Fujii, H; Horie, Y; Satoh, T; Ohkanda, J; Yokomori, Y;
Heterocycles, 49, 281-296, 1998 - New hexadentate ligands composed of 1-hydroxy-2(1H)-pyrimidinone, alpha,omega-diamine and 1,1,1-tris(carboxyethoxymethyl)-ethane or tri(carboxybutyl)isocyanurate. Synthesis and characterization of their iron(III) complexes
Katoh, A; Hida, Y; Kamitani, J; Ohkanda, J;
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, (22), 3859-3864, 1998 - Requirement for geranylgeranyl transferase I and acyl transferase in the TGF-beta-stimulated pathway leading to elastin mRNA stabilization
Kucich, U; Rosenbloom, JC; Shen, G; Abrams, WR; Blaskovich, MA; Hamilton, AD; Ohkanda, J; Sebti, SM; Rosenbloom, J;
Biochemical and biophysical research communications, 252(1), 111-116, 1998 - N-hydroxypyrazinone-bearing homotrioxacalix[3]arene: its cooperative molecular recognition by metal complexation
Ohkanda, J; Shibui, H; Katoh, A;
Chemical Communications, (3), 375-376, 1998 - N-hydroxyamide-containing heterocycles: Synthesis, reactivities, and iron(III)-chelating properties
Ohkanda, J; Katoh, A;
REVIEWS ON HETEROATOM CHEMISTRY, 18, 87-118, 1998 - Functionalized N-hydroxyamide-containing heterocycles - Synthesis, reaction, and metal-chelating property
Ohkanda, J; Katoh, A;
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 55(6), 524-534, Jun. 1997 - Synthesis of 1,3-linked 1,4-dihydropyridines containing the L-tyrosine residue and the influence of their structures upon the enantioselective reduction
Katoh, A; Naruse, S; Ohkanda, J; Yamamoto, H;
Heterocycles, 45(8), 1441-1446, 1997 - Novel iron sequestering agents: Synthesis and iron-chelating properties of hexadentate ligands composed of 1-hydroxy-2(1H)-pyrimidinone, omega-amino carboxylic acid, and tris(2-aminoethyl)amine
Ohkanda, J; Kamitani, J; Tokumitsu, T; Hida, Y; Konakahara, T; Katoh, A;
JOURNAL OF ORGANIC CHEMISTRY, 62(11), 3618-3624, 1997 - Structural analysis of N-(omega-phenylalkyl)substituted quinoxalin-2(1H)-ones and -thiones
Katoh, A; Yoshida, T; Ohkanda, J; Nishio, T;
Heterocycles, 44, 357-366, 1997 - N-hydroxyamide-containing heterocycles .7. Preparation and photochemical behavior of 1-benzyloxy-2(1H)-pyrazinones
Ohkanda, J; Kumasaka, T; Takasu, A; Hasegawa, T; Katoh, A;
Heterocycles, 43(4), 883-889, 1996 - Synthesis of novel amphiphilic compounds containing aza-12-crown-4 or D-glucosamine and their ion permeability
Katoh, A; Ishida, S; Ohkanda, J; Washizu, M;
Heterocycles, 43(3), 589-599, 1996 - Synthesis of 2,3-disubstituted 6-aminoquinoxalines and their application to new fluorescence derivatization reagents for carboxylic acids
Katoh, A; Takahashi, M; Ohkanda, J;
Chemistry Letters, (5), 369-370, 1996 - The influence of the chirality of synthetic iron chelators bearing N-hydroxy-2(1H)-pyrazinones and amino acid residues upon iron removal from human transferrin
Ohkanda, J; Katoh, A;
Chemistry Letters, (6), 423-424, 1996 - N-hydroxyamide-containing heterocycles .6. Application of 1-hydroxy-4,6-dimethyl-2(1H)-pyrimidinone to a new benzyloxycarbonylating agent
Katoh, A; Kondoh, S; Ohkanda, J;
HETEROCYCLIC COMMUNICATIONS, 2(2), 141-144, 1996 - N-HYDROXYAMIDE-CONTAINING HETEROCYCLES .5. SYNTHESIS OF NOVEL HEXADENTATE LIGANDS COMPOSED OF N-HYDROXY-2(1H)-PYRAZINONE, ALIPHATIC DIAMINE, AND 1,1,1-TRIS(CARBOXYETHOXYMETHYL)ETHANE, AND PROPERTIES OF THEIR FERRIC COMPLEXES
Ohkanda, J; Katoh, A;
Tetrahedron, 51(47), 12995-13002, 1995 - N-HYDROXYAMIDE-CONTAINING HETEROCYCLES .4. SYNTHESIS AND FE-III-CHELATING PROPERTIES OF NOVEL HEXADENTATE LIGANDS COMPOSED OF N-HYDROXY-2(1H)-PYRAZINONE, AMINO-ACID-RESIDUES, AND TRIS(2-AMINOETHYL)AMINE
Ohkanda, J; Katoh, A;
JOURNAL OF ORGANIC CHEMISTRY, 60(6), 1583-1589, 1995 - SYNTHESIS OF 2(1H)-PYRIMIDINONE-CONTAINING ALPHA-AMINO-ACID DERIVATIVES BY CHEMICAL MODIFICATION OF L-GLUTAMIC ACID
KATOH, A; INOKAWA, M; OHKANDA, J; MITSUHASHI, K;
CHEMICAL & PHARMACEUTICAL BULLETIN, 42(7), 1514-1517, Jul. 1994 - N-HYDROXYAMIDE-CONTAINING HETEROCYCLES .3. THE RING TRANSFORMATION OF 1-BENZYLOXY-2(1H)-PYRIMIDINONES INTO 2-ISOXAZOLINES WITH HYDROXYLAMINE
KATOH, A; OHKANDA, J; TAMURA, A; YOSHIIKE, Y; MITSUHASHI, K;
Heterocycles, 37(2), 1141-1146, 1994 - N-HYDROXYAMIDE-CONTAINING HETEROCYCLES .2. SYNTHESIS AND IRON(III) COMPLEX-FORMING TENDENCY OF 1-HYDROXY-2(1H)-PYRIMIDINONE AND 1-HYDROXY-2(1H)-PYRAZINONE
OHKANDA, J; TOKUMITSU, T; MITSUHASHI, K; KATOH, A;
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 66(3), 841-847, Mar. 1993 - A CONVENIENT SYNTHESIS OF 3-(ARYL)SUBSTITUTED 2,4(1H,3H)-PTERIDINEDIONES AND THEIR ABSORPTION AND FLUORESCENCE SPECTROSCOPIC CHARACTERISTICS
KATOH, A; OHKANDA, J; SATO, H; SAKAMOTO, T; MITSUHASHI, K;
Heterocycles, 35(2), 949-954, 1993 - N-HYDROXYAMIDE-CONTAINING HETEROCYCLES - NEW EFFECTIVE ADDITIVES FOR PEPTIDE-SYNTHESIS BY THE DICYCLOHEXYLCARBODIIMIDE METHOD
KATOH, A; OHKANDA, J; ITOH, Y; MITSUHASHI, K;
Chemistry Letters, (10), 2009-2012, Oct. 1992 - STRUCTURAL ASPECTS OF THE MECHANICAL AND THERMAL-DISSOCIATION OF THE CENTRAL BOND IN 2,2'-BIS(2,3,4-TRIARYLCHROMENYL)S
OHKANDA, J; MORI, Y; MAEDA, K; OSAWA, E;
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, (1), 59-63, Jan. 1992 - ISOLATION OF THE INTERMEDIATES AND IMPROVED SYNTHESIS OF PYRIDO[1',2'/1,2]IMIDAZOL[4,5-B]PYRAZINES AND PYRIDO[1',2'/1,2]IMIDAZOL]4,5-B]QUINOXALINES
KATOH, A; UEDA, SH; OHKANDA, J; HIROTA, M; KOMINE, H; MITSUHASHI, K;
Heterocycles, 34(10), 1965-1972, 1992 - UNUSUAL SUBSTITUENT EFFECT BY THE ALPHA-ACETYL GROUP ON THE TYPE-II PHOTOREACTION OF VALEROPHENONES - STRONG WAVELENGTH DEPENDENCE OF QUANTUM YIELDS
HASEGAWA, T; OHKANDA, J; KOBAYASHI, M; YOSHIOKA, M;
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 64(3), 299-306, 1992
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