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MIZUKI Masaru

Academic OrganizationTEL
Education and Research OrganizationSchool of Medicine Center for Perinatal, Pediatric and Environmental EpidemiologyFAX
PositionAssistant ProfessorMail Address
Address3-1-1, Asahi, Matsumoto City 390-8621Web site

Profile

Academic Background
College
信州大学 , (医学部) , 2013

Degree
学士(医学) , 信州大学

Research

Books, Articles, etc.
Articles
Association between sleep problems in infants and maternal sleep habits and parenting environment
Shinshu Journal of Public Health,15(2):45-54 2021(Apr.)
Author:元木倫子、島﨑雅士、上條怜音、笹尾祐介、中込健人、中村真波、新田温生、白旭坤、星影彰太郎、松井寛郎、山口廉之助、吉田真介、長谷川航平、當房浩一、水木将、上條知子、塚原照臣、野見山哲生
Abstract:目的:母親の睡眠行動や養育環境と幼児の睡眠の質との関連について調査した。 方法:長野県松本市の信州大学学内保育園に通園している 1 歳以上の児を持つ保護者 57 名を対象とし、自己記述式調査紙を用い調査した。主な質問項目は、子どもの睡眠習慣について、母親の睡眠習慣、勤務形態、養育環境とした。子どもの睡眠の質を評価するため、「日本版幼児睡眠質問票」の下位尺度の一部(パラソムニア、朝の症状、睡眠習慣、睡眠不足に関する評価項目)を用い、睡眠スコアを算出した。各下位尺度の点数または合計点が高得点で睡眠に問題があるとされている。睡眠スコアの中央値を用い、29 点未満の「低得点群」と 29 点以上の「高得点群」の 2 群に分け、基本属性や母子の睡眠習慣、養育環境について比較した。 結果:37 名(65%)から回答を得た。子どもの年齢は中央値 2 歳 1 か月で、全例で母親が回答した。 睡眠スコアで分けた低得点群(18 名)と高得点群(19 名)の基本属性や養育環境についての二群の比較では、兄弟の有無(一人っ子:低得点群 7 人 [38.9%]vs 高得点群 14 人 [73.7%]、P=0.049)と母親の電子機器使用時間(中央値:低得点群 1 時間 vs 高得点群 3 時間、p=0.012)で有意な差を認めた。これら2項目を独立変数とし、高得点群に寄与する要因を調べる目的でロジスティック回帰分析を施行したところ、子どもの睡眠スコアと有意な関連は見られなかった(一人っ子:調整済みオッズ比 3.51、95%信頼区間 0.79-15.5、p=0.098、母親が電子機器を使用する時間:調整済みオッズ比 1.26、95% 信頼区間0.97-1.63、p=0.086)。 考察:兄弟の有無、母親の電子機器使用時間と幼児の睡眠の質との関連について、単変量解析では有意差を認めたが、多変量解析では有意な関連を認めなかった。親と子が添い寝をする日本の文化では、家族の睡眠習慣が子どもの睡眠習慣に影響する可能性があり、就寝前の親の電子機器の使用について配慮が必要である。子どもの健やかな発育発達ため、家庭全体での睡眠に関連する生活習慣の見直しが望まれる。


Presentations
Efeccts of 1-bromopropane on the vibrarion perception thresholds of male workers
33rd International Congress on Occupational Health(ICOH 2022)
Presenter:Hirokazu Toubou, Masaru Mizuki, Kohei Hasegawa, Akito Takeuchi, Ryuta Abe, Teruomi Tsukahara and Tetsuo Nomiyam


MOCA取扱い作業者の保護手袋からのMOCA検出の試み
Presenter:山内武紀、大久保茂子、塚原照臣、水木将、長谷川航平、竹内靖人、西野入修、野見山哲生、山野優子


MISC
Effects of lactoferrin on sleep conditions in children aged 12-32 months: a preliminary, randomized, double-blind, placebo-controlled trial.
Nat Sci Sleep,12:671-677 2020
Author:Miyakawa M, Kubo S, Oda H, Motoki N, Mizuki M, Tsukahara T, Tanaka M, Yamauchi K, Abe F, Nomiyama T
Abstract:Purpose: To investigate preliminarily the effect of lactoferrin (LF)-fortified formula on sleep conditions in children. Study design: A preliminary, randomized, double-blind, placebo-controlled trial. Methods: Healthy children between the ages of 12 and 32 months who attended nursery schools in Japan were divided into two groups and assigned a placebo or LF (48 mg/day)-fortified formula. Children's sleep conditions were investigated before and after the 13-week intervention using the Japanese Sleep Questionnaire for Preschoolers (JSQ-P). Results: Altogether, 109 participants were randomized. Eight participants were eliminated due to lost to follow-up, withdrawal of consent, and ineligibility, with 101 participants (placebo, n = 48; LF, n = 53) included in the full analysis set (FAS) and used for analysis. Wake-up time, bedtime, and nighttime sleep were comparable between the two groups before and after intervention. The change in total JSQ-P T scores tended to improve in the LF group (placebo vs LF: 0.5 ± 6.5 vs -1.9 ± 6.1, p = 0.074), in particular, morning symptoms significantly improved (grumpy in the morning, hard to wake-up, and hard to get out of bed) (placebo vs LF: 0.8 ± 6.2 vs -1.9 ± 6.2, p = 0.028). A better trend was also observed in the LF group regarding restless legs syndrome (RLS)-motor (rubs feet at night and touches feet at night) (placebo vs LF: 2.3 ± 10.7 vs -0.6 ± 13.5, p = 0.083) and insufficient sleep (stays up more than one hour later the day before a holiday and wakes up more than one hour later on a holiday) (placebo vs LF: 0.1 ± 9.8 vs -1.7 ± 8.8, p = 0.095). No adverse drug reactions were found. Conclusion: LF intake may improve sleep condition, especially morning symptoms in children above one year of age.


Effects of lactoferrin-fortified formula on acute respiratory and gastrointestinal illnesses in children aged 12-32 months: A randomized, double-blind, placebo-controlled trial.
Front. Pediatr.,8:233 2020
Author:Motoki N, Mizuki M, Tsukahara T, Miyakawa M, Kubo S, Oda H, Tanaka M, Yamauchi K, Abe F, Nomiyama T
Abstract:Objective: We investigated the effects of lactoferrin (LF)-fortified formula on acute gastrointestinal and respiratory symptoms in children. Design: Randomized, double-blind, placebo-controlled trial. Setting and subjects: Children aged 12-32 months in Japan. Intervention: Intake of placebo or LF (48 mg/day)-fortified formula for 13 weeks. Primary endpoint: Prevalence of acute gastrointestinal and respiratory symptom. Results: One hundred nine participants were randomized. Eight participants were lost to follow-up, withdrew consent, or were deemed inappropriate for the trial, with 101 participants receiving complete analyses (placebo group, n = 48; LF group, n = 53). Outcomes: The prevalence of acute gastrointestinal symptoms was significantly less in the LF group (22/53 [41.5%]) than in the placebo group (30/48 [62.5%], p = 0.046). The total number of days having acute respiratory symptoms was significantly lower in the LF group (9.0) than in the placebo group (15.0, p = 0.030). Harms: The rate of adverse events was similar between the groups. No adverse drug reactions were found. Conclusions: LF intake decreased the prevalence of acute gastrointestinal symptoms in children aged 12-32 months.


Effects of lactoferrin on prevention of acute gastrointestinal symptoms in winter: A randomized, double-blinded, placebo-controlled trial for staff of kindergartens and nursery schools in Japan.
Int J Environ Res Public Health,17(24):9582-9582 2020
Author:Mizuki M, Tsukahara T, Oda H, Tanaka M, Yamauchi K, Abe F, Nomiyama T
Abstract:This study investigated the preventive effects of lactoferrin (LF) on subjective acute gastrointestinal symptoms during the winter in a randomized, double-blinded, placebo-controlled parallel-group comparative trial. The eligible subjects were healthy adults working at kindergartens and nursery schools. We randomized the subjects to the Placebo group (0 mg/day), the Low LF group (200 mg/day), and the High LF group (600 mg/day) for 12 weeks. The prevalence of acute gastrointestinal symptoms was significantly lower in the High LF (13/112 vs. 26/116; p = 0.030) and the Low LF (13/107 vs. 26/116; p = 0.040) groups than in the Placebo group. The adjusted odds ratio for the prevalence of acute gastrointestinal symptoms was 2.78 (95% CI: 1.19–6.47) in the Placebo group compared with the High LF group. LF is useful to prevent acute gastrointestinal symptoms among childcare workers, who mainly consist of women.