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Hidaka Hiroya

Academic OrganizationTEL
Education and Research OrganizationSchool of Medicine Department of Biomedical Laboratory SciencesFAX
PositionAssociate ProfessorMail Address
Address3-1-1, Asahi, Matsumoto City 390-8621Web site

Modified:04/12/2022

Profile

Research Field
Medical, Dental, and Pharmaceutical Science
Boundary Medicine
Laboratory medicine
Current Subject
The elucidation of the mechanism of lipidosis
Keywords:lipoproteins , phospholipid , apolipoprotein , cholesterol , triglyceride , 2003-
Adipose intestinal absorption and metabolism
Keywords:lipoproteins , phospholipid , cholesterol , 2003-
Analysis of HDL-binding proteins
Keywords:HDL , human mononuclear cells , apolipoprotein-AI , 2003-
Young life-style related diseases prevention and education
Keywords:life-stylerelated diseases , clinical laboratory test , metabolic syndrome , reference value , 2003-
Quality management of clinical laboratory tests
Keywords:clinical laboratory test , standardization , quality control , quality management , 2003-
Laboratory assessment of nutrition management
Keywords:lipoprotein , plasma proteins , vital trace element , 2003-
Analysis of phospholipid by mass spectrometry
Keywords:colin containing phospholipid , sphingolipid , fatty acid , mass spectrometry , MALDI-TOF MS , 1995-
Denaturation of the apolipoprotein
Keywords:sulfur-containing amino acid , partial hydrolysis , HPLC , mass spectrometry , electrophoresis , 1995-
Analysis and metabolism of high density lipoprotein (HDL)
Keywords:lipoprotein , particle size , electrophoresis , chromatography , mass spectrometry , 1989-
Academic Societies
Academic Societies
Japanese Society of Laboratory Medicine
Japabese Association of Medical Technology
Japan Atherosclerosis Society
The Society of Analytical Bio-Science
Japan Society of Clinical Chemistry
Academic Background
Graduate School
静岡県立静岡薬科大学 , (Graduate School, Division of Pharmaceutical Sciences) , 1980

College
Tokyo University of Pharmacy and Life Science , (薬学部) , 1977

Degree
博士(医学) , Shinshu University

Research

Books, Articles, etc.
Articles
Mild acid hydrolysis of sphingolipids yields lysosphingolipids: a matrix-assisted laser desorption and ionization time-of-flight mass spectrometry study
J Anal Bio-Sci,35(3):241-248 2012
Author:Hidaka H, Takiwaki M, Yamashita M, Otsuki S, Kawasaki K, Sugano M, Honda T


Consumption of Nonfat Milk Results in a Less Atherogenic Lipoprotein Profile: A Pilot Study
Ann Nutr Metab,61(2):111-116 2012
Author:Hidaka H, Takiwaki M, Yamashita M, Kawasaki K, Sugano M, Honda T. Hidaka H, Takiwaki M, Yamashita M, Kawasaki K, Sugano M, Honda T


透析患者におけるホモシステインと透析療法の検討
腎と透析,69:164-169 2010
Author:3. 塩澤 勉、中村啓章、田村克彦、長澤正樹、羽生 登、本田孝行、日高宏哉


High-molecular-weight beta-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients.
FASEB J,24(8):2716-2726 2010
Author:Fukumoto H, Tokuda T, Kasai T, Ishigami N, Hidaka H, Kondo M, Allsop D, Nakagawa M.


The Investigators of Study on Prevention of Metabolic Syndrome among Children, Adolescents, and YoungAdults in Shinshu: Association between serum uric acid levels and cardiometabolic risk factors among Japanese junior high school students.
Circ J,74:1570-1577 2010
Author:Hongo M, Hidaka H, Sakaguchi S, Nakanishi K, Ichikawa M, Hirota N, Tanaka N, Tsuruta G, Yazaki Y, Kinoshita O, Ikeda U, Koike K,


一般中学生の高尿酸血症と生活習慣病との関連
,33:17-26 2009
Author:本郷 実、日高宏哉、阪口しげ子、市川元基、池田宇一、田中直樹、鶴田悟郎、小池健一,


Characterization of cysteine and homocysteine bound to human serum transthyretin.
Clin Chim Acta.,403(1-2):70-75 2009
Author:Hanyu N, Shimizu T, Yamauchi K, Okumura N, Hidaka H.


Specific, rapid, and sensitive enzymatic measurement of sphingomyelin, phosphatidylcholine and lysophosphatidylcholine in serum and lipid extracts.
Clin Biochem.,41(14-15):1211-1217 2008
Author:Hidaka H, Yamauchi K, Ohta H, Akamatsu T, Honda T, Katsuyama T.


Fluvastatin improves arterial stiffness in patients with coronary artery disease and hyperlipidemia: a 5-year follow-up study.
Circ J.,72(5):722-728 2008
Author:Hongo M, Tsutsui H, Mawatari E, Hidaka H, Kumazaki S, Yazaki Y, Takahashi M, Kinoshita O, Ikeda U.


Analysis of human serum lipoprotein lipidcomposition using MALDI-TOF mass spectrometry.
Ann Clin Lab Sci.,37(3):213-221 2007
Author:Hidaka H, Hanyu N, Sugano M, Kawasaki K, Yamauchi K, Katsuyama T.


Degradation of pre-beta-high density lipoproteins and their binding activity to human blood monocytes
Ann Clin Lab Sci,34:287-298 2004
Author:Nakabayashi T, Yamauchi K, Sugano M, Sano K, Tozuka M, Hidaka H


Detection of monoclonal immunoglobulin by serum protein electrophoresis of samples from patient of Shinonoi General Hospital from 1992-2001
Jornal of Analytical Bio-Science,26:422-427 2003
Author:Hanyu N, Kawaguchi K, Hshizume S, Shimizu T, Tozuka M, Fujita K, Hidaka H


Purification and measurement of HDL3-binding proteins in human peripheral blood mononuclear cells
Ann Clin Lab Sci,33:271-278 2003
Author:Hidaka H, Tozuka M, Yamauchi K, Ohta H, Nakayama J, Katsuyama T


Characterization of an apolipoprotein E3 variant (Arg145->His) associated with mild hypertriglyceridemia.
Annals of clinical&laboratory science,31(2):163-170 2003
Author:Hiroya Hidaka, Minoru Tozuka, Eiko Hidaka, Kazuyoshi Yamauchi, Hiroyoshi Ota ,Takayuki Honda, and Tsutomu Katsuyama


Purification and measurement of HDL3-binding proteins present in human peripheral monocytes.
Annals of clinical&laboratory science,33(3) 2003
Author:Hiroya Hidaka, Minoru Tozuka, Kazuyoshi Yamauchi, Hiroyoshi Ohta,Jun Nakayama, and Tsutomu Katsuyama


Characterization of triglyceride rich lipoproteins with very light density by ultracentrifugation and agarose gel electrophoresis using triglyceride- and cholesterol-staining
Annals of clinical&laboratory science,33(2):167-178 2003
Author:Hiroya Hidaka, Minoru Tozuka, Barbara Meyer, Kazuyoshi Yamauchi, Mitsutoshi Sugano, Tetsuo Nakabayashi, and Tsutomu Katsuyama.


栄養アセスメント蛋白の測定法.-アルブ-ン,トランスフェリン,トランスサイレチン,レチノール結合蛋白-
検査と技術,30:1377-1382 2002
Author:日高宏哉,戸塚 実


自動生化学分析機を用いた免疫比濁法による血清および髄液中トランスサイレチンの測定
医学検査,51(8):1146-1149 2002
Author:笹野桂子、日高宏哉、菅野光俊、鈴木剛史、広仲英治、戸塚 実


Predominant apolipoprotein J exists as lipid-poor mixtures in cerebrospinal fluid
Ann Clin Lab Sci,32(4):369-376 2002
Author:Takefumi Suzuki,Minoru Tozuka, Kazuyoshi Yamauchi, Mitsutoshi Sugano, Testuo Nakabayashi, Nobuo Okumura, Hiroya Hidaka, Tshutomu Katsuyama


Isoform-specific effect of apolipoprotein E on endocytosis of beta-amyloid in cultures of neuroblastoma cells.
Annals of clinical&laboratory science,32(1):65-74 2002
Author:Kazuyoshi Yamauchi, Minoru Tozuka, Hiroya Hidaka,Tetsuo Nakabayashi , Mitsutoshi Sugano, and Tsutomu Katsuyama


Characterization of an apolipoprotein E3 variant (Arg 145 ->His) associated with mild hypertriglyceridemia
ANNALS OF CLINICAL AND LABORATORY SCIENCE,31(2):163-170 2001
Author:Hidaka, H; Tozuka, M; Hidaka, E; Yamauchi, K; Ota, H; Honda, T; Katsuyama, T


酵素法による液状カルシウム測定試薬「ダイヤカラー・リキッドCa」の基礎的検討
現代医療.,33:134-138 2001
Author:菅野光俊、日高宏哉、鈴木剛史、笹野桂子、広仲英治、野本昭三、戸塚 実


過去5年間、血清蛋白電気泳動法により検出されたM蛋白の集計
医学検査,50(8):1037-1041 2001
Author:羽生 登、橋詰幸子、田中順子、永井久美子、清水敏夫、戸塚 実、日高宏哉


LDアイソザイムの測定
検査と技術,29(12):1329-1336 2001
Author:羽生 登、清水敏夫、日高宏哉


リポ蛋白分画中の脂質組成の分析
検査と技術,29(9):1053-1059 2001
Author:日高宏哉、山内一由、戸塚 実


Cell Lineage Specificity of Newly Raised Monoclonal Antibodies Against Gastric Mucins in Normal, Metaplastic and Neoplastic Human Tissues and Their Application for Pathology Diagnosis.
American Journal of Clinical Pathology,115(1):69-79 2001
Author:Hiroyoshi Ota, Masayoshi Hayama, Jun Nakayama, Hiroya Hidaka, Takayuki Honda, Keiko Ishii, Mana Fukushima, Takeshi Uehara, Makoto Kurihara, Kazuhiko Ishihara, Kyoko Hotta, Tsutomu Katsuyama


Evaluation of the automatic fluorescent image analyzer,Image Titer, for quantitative analysis of antinuclear antibodies
Journal of Clin Pathology,115(3):424-429 2001
Author:Tetsuo Nakabayashi, Toshiko Kumagai, Kazuyoshi Yamauchi, Mitsutoshi Sugano, Kiyptaka Fujita, Hiroya Hidaka, Minoru Tozuka


Helicobacter pylori and two ultrastructurally distinct layers of gastric mucous cell mucins in the surface mucous gel layer
Gut.,49(4):474-480 2001
Author:Eiko Hidaka, Hiroyoshi Ota, Hiroya Hidaka, Masayoshi Hayama, Taiji Akamatsu, Jun Nakayama and Tsutomu Katsuyama


Size-related and size-unrelated functional heterogeneity among pancreatic islets
Life Science,69:2627-2639 2001
Author:Toru Aizawa, Tsuyoshi Kaneko, Keishi Yamauchi, Hiroki Yajima, Tomoko Nishizawa, Toshihiko Yada, Hiroshi Matsukawa, Minoru Nagai, Satoko Yamada, Yoshihiko Sato, Mitsuhisa Komatsu, Nobuo Itoh, Hiroya Hidaka, Yoshitaka Kajimoto and Kiyoshi Hashizume


Confirmation of minor components of less polar neutral and acidic glycolipids in monkey brain tissue.
Journal of Lipid Research,42:873-885 2001
Author:Tamotsu Taketomi,Eiko Sugiyama, Kei-ichi Uemura, Atsushi Hara, Hiroya Hidaka, Minoru Tozuka,Tetsuo Nakabayashi, and Tsutomu Katsuyama.


Analysis of hemoglobin and globin chain variants by a commonly used capillary isoelctric focusing method
Electrophoresis,21:3016-3019 2001
Author:Mitsutoshi Sugano, Hiroya Hidaka,Kazuyoshi Yamauchi, Tetsuo Nakabayashi,Yumiko Higuchi,Kiyotaka Fujita, Nobuo Okumura, Yoshihisa Ushiyama, Minoru Tozuka, and Tshutomu Katsuyama T.


イムノクロマトグラフィー法による感染症簡易検出キットの緊急検査適用についての検討-HBs抗原、HBs抗体およびTP抗体検出キットについて
医学検査,49(2):150-154 2000
Author:浜 尚枝、中林徹雄,熊谷俊子、日高宏哉,戸塚 実


合成基質を用いた液状リパ-ゼ測定試薬の検討
医学検査,49:1608-1611 2000
Author:菅野光俊、山内一由、広仲英治、中林徹雄、日高宏哉、戸塚 実


Coexistence of gland mucous cell-type mucin and lysozyme in gastric gland mucous cells
Histochem Biol Cell,113(2):91-98 2000
Author:Eiko Hidaka, Hiroyoshi Ota, Tsutomu Katsuyama, Jun Nakayama , Masanobu Momose, Hiroya Hidaka, Keiko Ishii, Fusayoshi Murata, Shinichiro Tsuyama, Makoto Kurihata, Kazuhiko Ishihara, Kyoko Hotta


Relation of Helicobacter pylori to mucins and mucouscells in human stomach.
Journal of Cell Molecular Medicine,4(3):224-225 2000
Author:Eiko Hidaka, Hiroyashi Ota, Masayoshi Hayama, Hiroya Hidaka, Keiko Ishii, Kosei Nakajima, Akihiko Yoshizawa, Tsutomu Katsuyama


Effect of apolipoprotein AII on the interaction of apolipoprotein E with beta-amyloid: some apo(E-AII) complexes inhibit the internalization of beta-amyloid in cultures of neuroblastoma cells.
Journal of Neuroscience Research,62(4):608-614 2000
Author:Kazuyoshi Yamauchi, Minoru Tozuka, Hiroya Hidaka, Tetsuo Nakabayashi, Mitsutoshi Sugano, KondoYoshiyuki, Akira Nakagawara, and Tshutomu Katsuyama


Genetic analyses in homozygous and heterozygous variants of lactate dehydrogenase-B(H) subunit-LD-B Matsumoto I and II (LD-B W323R)
Clinical Chimica Acta,287(1-2):163-171 1999
Author:Nobuo Okumura, Fumiko Terasawa, Ichiro Ueno, Keiko Oki, Kazuyoshi Yamauchi, Hiroya Hidaka, Minoru Tozuka, Mitsue Okura, Tsutomu Katsuyama


Higher avidity binding of apolipoprotein (E-AII) complex than of apolipoprotein E monomer to beta-amyloid
Journal of Neuroscience Research,58(2):301-307 1999
Author:Kazuyoshi Yamauchi, Minoru Tozuka, Tetsuo Nakabayashi, Mitsutoshi Sugano, Hiroya Hidaka, Yoshiyuki Kondo, Tsutomu Katsuyama


The identification of specific high density lipoprotein3 binding sites on human blood monocytes using fluorescence-labeled ligand.
Journal of Lipid Research,40(6):1131-1139 1999
Author:Hiroya Hidaka, Eiko Hidaka,Minoru Tozuka,Jun Nakayama, Tsutomu Katsuyama, and Noel Fidge


Characterization of apolipoprotein E-containing lipoproteins in cerebrospinal fluid: eddect of phenotype on the distribution of apolipoprotein E
Clinical Chemistry,45(9):1431-1438 1999
Author:Kazuyoshi Yamauchi, Minoru Tozuka, Hiroya Hidaka, Eiko Hidaka, Yoshiyuki Kondo, and Tsutomu Katsuyama

Research Grants
Grants‐in‐aid for Scientific Research(Research Representative)
2008 - 2010 , 炎症性腸管疾患の脂質及びアポ蛋白代謝機序と質量分析による病態指標検査法の開発 , 基盤研究(C)
2006 - 2007 , 炎症性腸管疾患の血清脂質とアポ蛋白の代謝機序を解明するための質量分析法の開発 , 萌芽研究