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HIGUCHI Yumiko

Academic OrganizationTEL
Education and Research OrganizationSchool of Medicine Department of Biomedical Laboratory SciencesFAX
PositionSenior Assistant ProfessorMail Address
Address3-1-1, Asahi, Matsumoto City 390-8621Web site

Research

Books, Articles, etc.
Books
Dendritic Cell-Based Cancer Immunotherapy Targeting Wilms’ Tumor 1 for Pediatric Cancer
Codon Publications 2016(Mar.)
Author:Shigetaka Shimodaira, Koichi Hirabayashi, Ryu Yanagisawa,Yumiko Higuchi, Kenji Sano, Tomonobu Koizumi


Articles
Fibrin monomers derived from thrombogenic dysfibrinogenemia, Naples-type variant (B beta Ala68Thr), showed almost entirely normal polymerization
THROMBOSIS RESEARCH,172:1-3 2018(Dec.)
Author:Kamijo, Tomu; Nagata, Kazuhiro; Taira, Chiaki; Higuchi, Yumiko; Arai, Shinpei; Okumura, Nobuo;


フィブリノゲン蓄積病を呈する異常フィブリノゲン産生細胞の繊維状封入体形成と小胞体ストレス応答
臨床病理 = The official journal of Japanese Society of Laboratory Medicine : 日本臨床検査医学会誌,66(10):1058-1064 2018(Oct.)
Author:上條 途夢;大久保 奈緒;平 千明;樋口 由美子;新井 慎平;奥村 伸生
Keywords:hypofibrinogenemia(フィブリノゲン低下症);fibrinogenstoragedisease:FSD(フィブリノゲン蓄積病);intracellularinclusionbodies(細胞内封入体);unfoldedproteinresponses:UPR(小胞体ストレス)


Feasibility and Immune Response of WT1 Peptide Vaccination in Combination with OK-432 for Paediatric Solid Tumors
ANTICANCER RESEARCH,38(4):2227-2234 2018(Apr.)
Author:Hirabayashi, Koichi; Yanagisawa, Ryu; Saito, Shoji; Higuchi, Yumiko; Koya, Terutsugu; Sano, Kenji; Koido, Shigeo; Okamoto, Masato; Sugiyama, Haruo; Nakazawa, Yozo; Shimodaira, Shigetaka;


Clinical effect and immunological response in patients with advanced malignant glioma treated withWT1-pulsed dendritic cell-based immunotherapy: A report of two cases
Interdisciplinary Neurosurgery,9:24-29 2017(Sep.)
Author:Sakai, K., Shimodaira, S., Maejima, S., Sano, K., Higuchi, Y., Koya, T., Sugiyama H. & Hongo, K.


Interferon-alpha-inducible Dendritic Cells Matured with OK-432 Exhibit TRAIL and Fas Ligand Pathway-mediated Killer Activity
SCIENTIFIC REPORTS,7:- 2017
Author:Koya, Terutsugu; Yanagisawa, Ryu; Higuchi, Yumiko; Sano, Kenji; Shimodaira, Shigetaka;


WT1 Peptide Vaccine is Unaffected by Airport Screening X-Irradiation
Vaccines & Immunother.,3(1) 2016(Sep.)
Author:Higuchi Y, Kawakubo M, Yuzawa M, Sano K and Shimodaira S.


Quality Verification of Dendritic Cell-Based Cancer Vaccine
Pharm Anal Acta 2016(Jul.)
Author:Shigetaka Shimodaira, Terutsugu Koya, Yumiko Higuchi, Masato Okamoto, Shigeo Koido


Efficacy of dendritic cell-based cancer immunotherapy
Biochem Anal Biochem 2016(May)
Author:Shigetaka Shimodaira, Yumiko Higuchi, Ryu Yanagisawa, Masato Okamoto, Shigeo Koido.


An update on Dendritic Cell-Based Cancer Immunotherapy
Immunome Res,12(1) 2016(Mar.)
Author:Shimodaira S, Hirabayashi K, Koya T, Higuchi Y, Yanagisawa R, Okamoto M and Koido S


Standard WT1 Expression Using Immunohistochemistry
J Mol Biomark Diagn,(7):266 2015(Dec.)
Author:Shigetaka Shimodaira Yumiko Higuchi, Ryu Yanagisawa, Masato Okamoto, Shigeo Koido.


Dendritic Cell-Based Adjuvant Vaccination Targeting Wilms’ Tumor 1 in Patients with Advanced Colorectal Cancer
,3:1004-1018 2015(Dec.)
Author:Shigetaka Shimodaira, Kenji Sano, Koichi Hirabayashi, Terutsugu Koya , Yumiko Higuchi, Yumiko Mizuno, Naoko Yamaoka, Miki Yuzawa, Takashi Kobayashi, Kenichi Ito, and Tomonobu Koizumi


Enzyme-Linked Immunosorbent Spot Assay for the Detection Of Wilms’ Tumor 1-Specific T Cells Induced by Dendritic Cell Vaccination Cell Vaccination
Biomedicines ,3:304-315 2015(Dec.)
Author:Yumiko Higuchi, Terutsugu Koya, Miki Yuzawa, Naoko Yamaoka, Yumiko Mizuno, Kiyoshi Yoshizawa, Koichi Hirabayashi, Takashi Kobayashi 3, Kenji Sano, and Shigetaka Shimodaira


Dendritic cell-based immunotherapy targeting Wilms' tumor 1 in patients with recurrent malignant glioma
JOURNAL OF NEUROSURGERY,123(4):989-997 2015(Oct.)
Author:Sakai, Keiichi; Shimodaira, Shigetaka; Maejima, Shinya; Udagawa, Nobuyuki; Sano, Kenji; Higuchi, Yumiko; Koya, Terutsugu; Ochiai, Takanaga; Koide, Masanori; Uehara, Shunsuke; Nakamura, Midori; Sugiyama, Haruo; Yonemitsu, Yoshikazu; Okamoto, Masato; Hongo, Kazuhiro;


Future Prospective of Cancer Vaccination Technology in Japan
Pharmaceut Reg Affairs,4(2) 2015(Jul.)
Author:Shimodaira S, Hirabayashi K, Kobayashi T, Higuchi Y and Yokokawa K


Induction of Antigen-Specific Cytotoxic T Lymphocytes by Chemoradiotherapy in Patients Receiving Wilms’ Tumor 1-Targetted Dendritic Cell Vaccinations for Pancreatic Cancer
J Radiol,4(4) 2015(Jul.)
Author:Shimodaira S, Kobayashi T, Hirabayashi K, Horiuchi K, Koya T, Mizuno Y, Yamaoka N, Yuzawa M, Ishikawa S, Higuchi Y, Sano K, Ito K, and Koizumi T


Smoking influences the yield of dendritic cells for cancer immunotherapy
Pharmaceut Reg Affairs,4(133) 2015(Apr.)
Author:Shimodaira S, Higuchi Y, Koya T, Kobayashi T, Yanagisawa R


Safety and tolerability of allogeneic dendritic cell vaccination with induction of Wilms tumor 1-specific T cells in a pediatric donor and pediatric patient with relapsed leukemia: a case report and review of the literature
CYTOTHERAPY,17(3):330-335 2015(Mar.)
Author:Saito, Shoji; Yanagisawa, Ryu; Yoshikawa, Kentaro; Higuchi, Yumiko; Koya, Terutsugu; Yoshizawa, Kiyoshi; Tanaka, Miyuki; Sakashita, Kazuo; Kobayashi, Takashi; Kurata, Takashi; Hirabayashi, Koichi; Nakazawa, Yozo; Shiohara, Masaaki; Yonemitsu, Yoshikazu; Okamoto, Masato; Sugiyama, Haruo; Koike, Kenichi; Shimodaira, Shigetaka;


A case of Behcet's disease associated with myelodysplastic syndrome involving trisomy 8 and a gain-of-function mutation in SHP-2
RHEUMATOLOGY,50(7):1342-1344 2011(Jul.)
Author:Shigemura, Tomonari; Agematsu, Kazunaga; Yamazaki, Takashi; Sakashita, Kazuo; Nakayama, Yoshiko; Higuchi, Yumiko; Matsuda, Kazuyuki; Koike, Kenichi;


WT1 AND MUC1-PULSED DENDRITIC CELL VACCINATION THERAPY FOR NON-SMALL-CELL LUNG CANCER
JOURNAL OF THORACIC ONCOLOGY,6(6):S1266-S1267 2011(Jun.)
Author:Kobayashi, Takashi; Koizumi, Tomonobu; Tateishi, Kazunari; Urushihata, Kazuhisa; Yamamoto, Hiroshi; Hanaoka, Masayuki; Kubo, Keishi; Shimodaira, Shigetaka; Yanagisawa, Ryu; Muramatsu, Saori; Higuchi, Yumiko; Goto, Takahumi; Ishikawa, Shinsuke;


Simple polymerase chain reaction for the detection of mutations and deletions in the epidermal growth factor receptor gene: Applications of this method for the diagnosis of non-small-cell lung cancer
CLINICA CHIMICA ACTA,401(1-2):68-72 2009(Mar.)
Author:Uhara, Miho; Matsuda, Kazuyuki; Taira, Chiaki; Higuchi, Yumiko; Okumura, Nubuo; Yamauchi, Kazuyoshi;


CD20-Negative CD138-Positive Leukemic Large Cell Lymphoma with Plasmablastic Differentiation with an IgH/MYC Translocation in an HIV-Positive Patient
INTERNAL MEDICINE,48(7):559-562 2009
Author:Yotsumoto, Mihoko; Ichikawa, Naoaki; Ueno, Mayumi; Higuchi, Yumiko; Asano, Naoko; Kobayashi, Hikaru;


CD38 expression by hematopoietic stem cells of newborn and juvenile mice.
Leukemia,17(1):171-174 2003(Jan.)
Author:Higuchi Y, Zeng H, Ogawa M.


Analysis of hemoglobin and globin chain variants by a commonly used capillary isoelectric focusing method
Electrophoresis,21:3016-3019 2000(Sep.)
Author:Sugano M, Hidaka H, Yamauchi K, Nakabayahsi T, Higuchi Y, Fujita K, Okumura N, Ushiyama Y, Tozuka M, Katsuyama T.


Thrombopoietin enhances neutrophil production by bone marrow hematopoietic progenitors with the aid of stem cell factor in congenital neutropenia
Jounal of Leukocyte Biology.,68(1):137-143 2000(Jul.)
Author:Sawai N, Koike K, Mwamtemi HH, Ito S, Kurokawa Y, Sakashita K, Kinoshita T, Higuchi T, Takeuchi K, Shiohara M, Kamijo T, Higuchi Y, Miyazaki H, Kato T,Kobayashi M, Miyake M, Yasui K, Komiyama A.


Plasminogen Kanagawa-I,a novel missense mutation, is caused by the amino acid substitution G732R
British Journal of Haematology,103:867-870 1998(Sep.)
Author:Higuchi Y, Furihata K, Ueno I, Ishikawa S, Okumura N, Tozuka M, Sakurai N.


Establishment of a GM-CSF-dependent megakaryoblastic cell line with the potential to differentiate into an eosinophilic lineage in response to retinoic acids
British Journal of Haematology.,100(2):427-435 1998(Feb.)
Author:Ma F, Koike K, Higuchi T, Kinoshita T, Takeuchi K, Mwamtemi HH, Sawai N, Kamijo T, Shiohara M, Horie S, Kawa S, Sasaki Y, Hidaka E, Yamagami O, Yamashita


Megakaryocytes derived from CD34-positive cord blood cells produce interleukin-8
British Journal of Haematology,99:509-516 1997(Dec.)
Author:Higuchi T,Koike K,Sawai N,Mwamtemi HH, Takeuchi K,Shiohara M, Kikuchi T, Yasui K, Ito S, Yamagami O, Sasaki Y, Okumura N, Kato T, Miyazaki H, Ikeda M, Yamada M, Komiyama A.


Fibrinogen Matsumoto III: a variant with 275Arg→Cys(CGC→TGC) -comparison of fibrin polymerization with those of Matsumoto I (364Asp→His) and Matsumoto II (308Asn→Lys)
Thrombosis and Haemostasis,81(5):763-766 1995(May)
Author:Terasawa F, Okumura N, Higuchi Y, Ishikawa S, Tozuka M, Kitano K, Katsuyama T.