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HIRATSUKA Sachie

Academic OrganizationAcademic Assembly School of Medicine and Health Sciences Institute of MedicineTEL
Education and Research OrganizationInterdisciplinary Cluster for Cutting Edge Research Institute for Biomedical SciencesFAX
PositionProfessorMail Address
Address3-1-1, Asahi, Matsumoto City 390-8621Web site

Profile

Assigned Class
School of Medicine Department of Biochemistry and Molecular Biology
Research Field
Oncology
Metastasis
Angiogenesis
Inflammation
Academic Background
Graduate School
Graduate School of Medicine and Faculty of Medicine, The University of Tokyo , 1998

College
Shimane Medical University , 1991
Awards
2019 , Kiyoko and Paul Bourdarie-Goto Scientific Prize-Special Award
Award of the Japanese Cancer Association
Research Career
Research Career
2018- , Department of Biochemistry and Molecular Biology, Shinshu University School of Medicine Professor
2011- , Japan Science and Technology Agency PRESTO Researcher
2010- , Department of Pharmacology, Tokyo Women’s Medical University, Associate professor
2007- , Harvard University Massachusetts General Hospital Post doctoral fellow
2002- , Department of Pharmacology, Tokyo Women’s Medical University, Assistant professor
2001-
1998-
1998- , Division of Genetics, The Institute of Medical Science, The University of Tokyo Assistant professor
1991- , Department of Pediatrics, Kyoto University medical intern

Research

Books, Articles, etc.
Articles
Regulation of vascular permeability in cancer metastasis
Cancer Science, 2021
Author:Tomita T, Kato M, Hiratsuka S


Extracellular mRNA transported to the nucleus exerts translation-independent function.
Nature Communications,12 2021
Author:Tomita T, Kato M, Mishima T, Matsunaga Y, Sanjo H, Ito, K, Minagawa K, Matsui T, Oikawa H, Takahashi S, Takao T, Iwai N, Mino T, Takeuchi O, Maru Y, Hiratsuka S


Hepato-entrained B220+CD11c+NK1.1+ cells regulate pre-metastatic niche formation in the lung.
EMBO Mol. Med,(e8643) 2018
Author:Hiratsuka S., Tomita T., Mishima T., Matsunaga Y., Omori T., Ishibashi S., Yamaguchi S., Hosogane T., Watarai H., Omori-Miyake M., Yamamoto T., Shibata N., Watanabe A., Aburatani H., Tomura M., High. KA., Maru Y.


Pre-metastatic niches: organ-specific homes for metastases
Nature Reviews Cancer,(17):302-317 2017
Author:David Lyden, Hector Peinado, Haiying Zhang, Irina Matei, Bruno Costa-Silva, Hoshino Ayuko, Goncalo Rodrigues, Bethan Psaila, Rosandra Kaplan, Jacqueline Bromberg, Yibin Kang, Mina Bissell, Thomas Cox, Amato Giaccia, Janine Erler, Sachie Hiratsuka, and Cyrus Ghajar


Primary tumours modulate innate immune signalling to create pre-metastatic vascular hyperpermeability foci.
Nature Communications,4(1853) 2013
Author:Hiratsuka S., Ishibashi S., Tomita T., Watanabe A., Akashi-Takamura S., Murakami M., Kijima H., Miyake K., Aburatani H., Maru


C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells.
Proc Natl Acad Sci U S A,(108):302-307 2011
Author:Hiratsuka S, Duda DG, Huang Y, Goel S, Sugiyama T, Nagasawa T, Fukumura D, Jain RK.


Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation.
Proc Natl Acad Sci U S A,(108):3725-3730 2011
Author:Hiratsuka S, Goel S, Kamoun WS, Maru Y, Fukumura D, Duda DG, Jain RK


The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase.
,Nat. Cell Biol.(10):1349-1355 2008
Author:Hiratsuka S, Watanabe A, Sakurai Y, Akashi-Takamura S, Ishibashi S, Miyake K, Shibuya M, Akira S, Aburatani H, Maru Y


Tumor-mediated upregulation of chemoattractants and recruitment of myeloid cells pre-determines lung metastasis.
,Nat. Cell Biol.(8):1369-1375 2006
Author:Hiratsuka S, Watanabe A, Aburatani H, Maru Y.


Involvement of MMP9 induction by Vascular Endothelial Growth Factor Receptor-1 in lung specific metastasis
Cancer Cell,2:289-300 2002
Author:Hiratsuka S, Nakamura K, Iwai S, Murakami M, Itoh T, Kijima H, Shipley JM, Senior RM, Shibuya M.