HIRATSUKA Sachie
Academic Assembly School of Medicine and Health Sciences Institute of Medicine
Interdisciplinary Cluster for Cutting Edge Research Institute for Biomedical Sciences
Professor
Researcher Information
Research Keyword
- Tumor, Metstasis
Career
- 2018
Department of Biochemistry and Molecular Biology, Shinshu University School of Medicine Professor - 2011
Japan Science and Technology Agency PRESTO Researcher - 2010
Department of Pharmacology, Tokyo Women’s Medical University, Associate professor - 2007
Harvard University Massachusetts General Hospital Post doctoral fellow - 2002
Department of Pharmacology, Tokyo Women’s Medical University, Assistant professor - 2001
学術振興会未来開拓リサーチアソシエイト - 1998
Division of Genetics, The Institute of Medical Science, The University of Tokyo Assistant professor - 1998
東京大学医科学研究所 腫瘍抑制 教務補佐員 - 1991
Department of Pediatrics, Kyoto University medical intern
Research activity information
Award
Paper
- Suppression of CEBPδ recovers exhaustion in anti-metastatic immune cells.
Yin C, Kato M, Tomita T, Han Y Hiratsuka S
Scientific Reports, 13(3903), 2023 - Citrullinated fibrinogen-SAAs complex causes vascular metastagenesis
Han Y, Tomita T, Kato M, Ashihara N, Higuchi Y, Matoba H, Wang W, Hayashi H, Itoh Y, Takahashi S, Kurita H, Nakayama J, Okumura N, Hiratsuka S
NATURE COMMUNICATIONS, 14(4960), 2023 - Extracellular mRNA transported to the nucleus exerts translation-independent function.
Tomita T, Kato M, Mishima T, Matsunaga Y, Sanjo H, Ito, K, Minagawa K, Matsui T, Oikawa H, Takahashi S, Takao T, Iwai N, Mino T, Takeuchi O, Maru Y, Hiratsuka S
NATURE COMMUNICATIONS, 12, 2021
Corresponding - Regulation of vascular permeability in cancer metastasis
Tomita T, Kato M, Hiratsuka S
Cancer Science,, 2021
Corresponding
- Hepato-entrained B220+CD11c+NK1.1+ cells regulate pre-metastatic niche formation in the lung.
Hiratsuka S., Tomita T., Mishima T., Matsunaga Y., Omori T., Ishibashi S., Yamaguchi S., Hosogane T., Watarai H., Omori-Miyake M., Yamamoto T., Shibata N., Watanabe A., Aburatani H., Tomura M., High. KA., Maru Y.
EMBO Mol. Med, (e8643), 2018 - Pre-metastatic niches: organ-specific homes for metastases
David Lyden, Hector Peinado, Haiying Zhang, Irina Matei, Bruno Costa-Silva, Hoshino Ayuko, Goncalo Rodrigues, Bethan Psaila, Rosandra Kaplan, Jacqueline Bromberg, Yibin Kang, Mina Bissell, Thomas Cox, Amato Giaccia, Janine Erler, Sachie Hiratsuka, and Cyrus Ghajar
Nature Reviews Cancer, (17), 302-317, 2017 - Primary tumours modulate innate immune signalling to create pre-metastatic vascular hyperpermeability foci.
Hiratsuka S., Ishibashi S., Tomita T., Watanabe A., Akashi-Takamura S., Murakami M., Kijima H., Miyake K., Aburatani H., Maru
Nature Communications, 4(1853), 2013 - Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation.
Hiratsuka S, Goel S, Kamoun WS, Maru Y, Fukumura D, Duda DG, Jain RK
Proc Natl Acad Sci U S A, (108), 3725-3730, 2011 - C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells.
Hiratsuka S, Duda DG, Huang Y, Goel S, Sugiyama T, Nagasawa T, Fukumura D, Jain RK.
Proc Natl Acad Sci U S A, (108), 302-307, 2011 - The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase.
Hiratsuka S, Watanabe A, Sakurai Y, Akashi-Takamura S, Ishibashi S, Miyake K, Shibuya M, Akira S, Aburatani H, Maru Y
Nat. Cell Biol., (10), 1349-1355, 2008 - Tumor-mediated upregulation of chemoattractants and recruitment of myeloid cells pre-determines lung metastasis.
Hiratsuka S, Watanabe A, Aburatani H, Maru Y.
Nat. Cell Biol., (8), 1369-1375, 2006 - Involvement of MMP9 induction by Vascular Endothelial Growth Factor Receptor-1 in lung specific metastasis
Hiratsuka S, Nakamura K, Iwai S, Murakami M, Itoh T, Kijima H, Shipley JM, Senior RM, Shibuya M.
CANCER CELL, 2, 289-300, 2002
Lead
