Tomotsune Daihachiro
Academic Assembly School of Medicine and Health Sciences Institute of Medicine
Interdisciplinary Cluster for Cutting Edge Research Institute for Biomedical Sciences
Assistant Professor
Researcher Information
Research activity information
Paper
- Cell biological profiling of reprogrammed cancer stem cell-like colon cancer cells maintained in culture
Hirashima, K., Yue, F., Kobayashi, M., Uchida, Y., Nakamura, S., Tomotsune, D., Matsumoto, K., Takizawa, S., Yokoyama, T., Tani, R., Sasaki, K
08 Oct. 2018 - Simulation of Embryonic Environments Produced by the Effect of Estradiol on Induced Pluripotent Stem Cells
Sakai, S., Tomotsune, D., Hirashima, K., Takizawa, S., Yokoyama, T., Yue, F., Tani, R., Matsumoto, K., Sasaki, K
01 Jul. 2018 - Cardiac portion of the stomach: a deep region within the abdomen
Hirashima K, Yue F, Tomotsune D, Sasaki K
Abdomen, First online, 31 Jul. 2017 - Simple Isolation of Pancreatic Progenitor Cells from Human Induced Pluripotent Stem Cells Using the ALDEFLUOR.
Nakamura, S., Takizawa-Shirasawa S., Yokoyama T., Tomotsune, D*., Sasaki,K.
Stem Cell Adv Res Ther., CRT-111, 17 Jan. 2017 - Reprogramming of retinoblastoma cancer cells into cancer stem cells.
Yue, F., Hirashima, K., Tomotsune D., Takizawa-Shirasawa S., Yokoyama T.,Sasaki,K
Biochem Biophys Res Commun., S0006-291X(16) 31928-3, 14 Nov. 2016 - Earlobe-like peritoneal appendage near the angle of His: a useful landmark for demarcating the lateral margin of the gastric cardia.
Hirashima, K., Yue, F., Tomotsune D., Sasaki K.
Anatomical Science International., s12565-016-374-6, 22 Sep. 2016 - Enrichment of Pluripotent Stem Cell-Derived Hepatocyte-Like Cells by Ammonia Treatment.
Tomotsune, D., Hirashima K., Fujii M., Yue F., Matsumoto K., Takizawa-Shirasawa S., Yokoyama T., Sasaki K.
PLOS ONE, 11(9), e0162693, 15 Sep. 2016, Refereed
- New model for cardiomyocyte sheet transplantation using a virus-cell fusion technique
Takahashi Y., Tomotsune D., Takizawa S., Yue F., Nagai M., Yokoyama T., Hirashima K., Sasaki K.
World J Stem Cells, 7(5), 883-893, 2015 - Effects of Fluid Dynamic Forces Created by Rotary Orbital Suspension Culture on Cardiomyogenic Differentiation of Human Embryonic Stem Cells
Mogi A, Takei S, Shimizu H, Miura H, Tomotsune D, Sasaki K
J. Med. Biol. Eng., 32(2), 101-108, 2014 - FGF7 and cell density are required for final differentiation of pancreatic amylase-positive cells from human ES cells.
Takizawa-Shirasawa S, Yoshie S, Yue F, Mogi A, Yokoyama T, Tomotsune D, Sasaki K.
Cell Tissue Res., 354, 751-759, 2013 - Establishment of novel detection system for embryonic stem cell-derived hepatocyte-like cells based on nongenetic manipulation with indocyanine green
Yoshie S, Ito J, Shirasawa S, Yokoyama T, Fujimura Y, Takeda K, Mizuguchi M, Matsumoto K, Tomotsune D, Sasaki K.
Tissue Eng Part C Methods, 18(1), 12-20, 2012 - Gene pathway analysis of the mechanism by which the Rho-associated kinase inhibitor Y-27632 inhibits apoptosis in isolated thawed human embryonic stem cells
Ichikawa H, Nakata N, Abo Y, Shirasawa S, Yokoyama T, Yoshie S, Yue F, Tomotsune D, Sasaki K.
Cryobiology, 64(1), 12-22, 2012 - Unique kinetics of Oct3/4 microlocalization following dissociation of human embryonic stem cell colonies.
Ichikawa H, Kanoh Y, Shirasawa S, Yokoyama T, Yue F, Tomotsune D, Sasaki K.
Ann Anat., 195, 50-56, 2012 - A Novel Stepwise Differentiation of Functional Pancreatic Exocrine Cells from Embryonic Stem Cells
Shirasawa S, Yoshie S, Yokoyama T, Tomotsune D, Yue F, Sasaki K
Stem Cells Dev, 20(6), 1071-1078, 2011 - A novel potent tumour promoter aberrantly overexpressed in most human cancers
Takahashi A, Tokita H, Takahashi K, Takeoka T, Murayama K, Tomotsune D, Ohira M, Iwamatsu A, Ohara K, Yazaki K, Koda T, Nakagawara A, Tani K.
SCIENTIFIC REPORTS, 1(15), 1-12, 2011 - Freeze-thawing single human embryonic stem cells induce E-cadherin and actin filament network disruption viaG13 signaling
Ichikawa H, Yoshie S, Shirasawa S, Yokoyama T, Yue F, Tomotsune D, Sasaki K.
Cryo Letter, 32(6), 516-524, 2011 - Pancreatic exocrine enzyme-producing cell differentiation via embryoid bodies from human embryonic stem cells
Shirasawa S, Yoshie S, Yue F, Ichikawa H, Yokoyama T, Nagai M, Tomotsune D, Hirayama M, Sasaki K
Biochem Biophys Res Commun, 410(3), 608-613, 2011 - In vitro transdifferentiation of HepG2 cells to pancreatic-like cells by CCl2, D-galactosamine, and ZnCl2
Kanoh Y, Tomotsune D, Shirasawa S, Yoshie S, Ichikawa H, Yokoyama T, Mae S, Ito J, Mizuguchi M, Matsumoto K, Yue F, Sasaki K.
Pancreas, 40(8), 1245-1252, 2011 - Lanford medium induces high quality hepatic lineage cell differentiation directly from mouse embryonic stem cell-derivedmesendoderm
Yoshie S, Shirasawa S,Yokoyama T, Kanoh Y, Takei S, Mizuguchi M, Matsumoto K, Tomotsune D, Sasaki K
Biochem Biophys Res Commun, 391(3), 1477-1482, 2010 - Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells
Mae S, Shirasawa S, Yoshie S, Sato F, Kanoh Y, Ichikawa H, Yokoyama T, Yue F, Tomotsune D, Sasaki K
Biochem Biophys Res Commun, 393(4), 877-882, 2010 - Differentiation of primate ES cells into retinal cells induced by ES cell-derived pigmented cells
Yue F, Johkura K, Shirasawa S, Yokoyama T, Inoue Y, Tomotsune D, Sasaki K
394(4), 877-883, 2010 - Bone marrow stromal cells as an inducer for cardiomyocyte differentiation from mouse embryonic stem cells
Yue F, Johkuraa K, Tomotsune D, Shirasawa S, Yokoyama T, Nagai M, Sasaki K
Ann Anat, 192(5), 314-321, 2010 - The method of mouse embryoid body establishment affects structure and developmental gene expression
Mogi A, Ichikawa H, Matsumoto C, Hieda T, Tomotsune D, Sakaki S, Yamada S, Sasaki K
Tissue Cell, 41(1), 79-84, 2009 - Bone morphogenetic protein-4 promotes induction of cardiomyocytes from human embryonic stem cells in serum-based embryoid body development
Takei S, Ichikawa H, Johkura K, Mogi A, No H, Yoshie S, Tomotsune D, Sasaki K
Am J Physiol Heart Circ Physiol, 296(6), H1793-803, 2009 - Hepatocyte Differentiation from Human ES Cells using the Simple Embryoid Body Formation Method and the Staged-Additional Cocktail
Sasaki K, Ichikawa H, Takei S, No H-S, Tomotsune D, Kano Y, Yokoyama T, Sirasawa S, Mogi A, Yoshie S, Sakaki S, Yamada S, Matsumoto K, Mizuguchi M, Yue F, Tanaka Y
ScientificWorld JOURNAL, 9, 884-890, 2009
- Increased expression of proapoptotic BMCC1, a novel gene with the BNIP2 and Cdc42GAP homology (BCH) domain, is associated with favorable prognosis in human neuroblastomas
Machida, T; Fujita, T; Ooo, ML; Ohira, M; Isogai, E; Mihara, M; Hirato, J; Tomotsune, D; Hirata, T; Fujimori, M; Adachi, W; Nakagawara, A
Oncogene, 25(13), 1931-1942, 2006
Books and other publications
- Regenerative Medicine and Tissue Engineering
Yue F, Shirasawa S, Ichikawa H, Yoshie S, Mogi A, Masuda S, Nagai M, Yokohama T, Tomotsune D Sasaki K, Induce Differentiation of Embryonic Stem Cells by Co-Culture System.
InTech, 117-139 2013Advances in Regenerative Medicine
Tomotsune D., Sato F., Yoshie S., Shirasawa S., Yokoyama T., Kanoh Y., Ichikawa H., Mogi M., Yue F., Sasaki K., A Strategy Using Pluripotent Stem Cell-Derived Hepatocytes for Stem Cell-Based Therapies
InTech, 145-164 2011Lectures, oral presentations, etc.
- 増殖制御培養液を用いたヒト線維芽細胞の生細胞輸送の検討
滝澤佐季子、藤倉純代、藤本俊介、正田雅輝、岳鳳鳴、友常大八郎
日本組織培養学会, 07 Jul. 2022増殖制御培養したヒト骨髄由来間葉系幹細胞の特性解析
藤本 俊介、正田 雅輝、鬼柳 由美子、冨田 優太、岳 鳳鳴、友常 大八郎、滝澤 佐季子
第２１回 再生医療学会, Mar. 2022ヒト線維芽細胞の増殖制御培養と特性評価
藤本俊介、正田 雅輝、鬼鬼柳由美子、冨田優太、岳 鳳鳴、友常 大八郎、滝澤佐季子
第２０回再生医療学会総会, Mar. 2021ヒト線維芽細胞の増殖制御培養と特性評価
滝澤佐季子、藤本俊介、岳 鳳鳴、鬼柳由美子、冨田優太、友常 大八郎
第２０回再生医療学会総会, Mar. 2021骨形成・骨再生を促進する遺伝子の探索
石田悠、羽二生久夫、友常大八郎、齋藤直人
第２０回再生医療学会総会, Mar. 2021PROLIFERATION CONTROL CULTURE OF HUMAN ADIPOSE DERIVED STEM CELLS
Shunsuke Fujimoto, Mieko Takasaka, Yumiko Kiyanagi, Yuta Tomita, Fengming Yue, Daihachiro Tomotsune, Katsunori Sasaki, Naoto Saito, Sakiko Takizawa-Shirasawa
第４３回日本分子生物学会年会, Dec. 2020PROLIFERATION CONTROL CULTURE OF HUMAN ADIPOSE DERIVED STEM CELLS
S., Fujimoto, M., Takasaka, Y., Kiyanagi, Y., T., F., Yue, D., Tomotsune, K., Sasaki, N., Saito, S., Takizawa-Shirasawa
ISSCR, Jun. 2020Purification of ALDH positive pancreatic cancer stem cells using ALDEFLUOR
岳鳳鳴、佐々木志織、城倉 浩平、友常 大八郎
第1８回 日本再生医療学会, Mar. 2020