Shinshu University HOMEJAPANESEAccess / Campus Map

Shinshu University Researcher DirectoryShinshu University Researcher Directory

Search by Researcher / Research Field
Search by Category

Okumura Nobuo

Academic OrganizationAcademic Assembly School of Medicine and Health Sciences Institute of Health ScienceTEL
Education and Research OrganizationSchool of Medicine Department of Biomedical Laboratory SciencesFAX
PositionProfessorsMail Address
AddressWeb site

Modified:09/10/2019

Profile

Research Field
Pathological Examination
Pathological Medical Chemistry
Current Subject
Functional analysis for citrullinated fibrinogen and fibrin
Keywords:citrullinated fibrinogen , citrullinated fibrin , 2007-
Molecular biological research for causes of fibrinogen deficiency
Keywords:fibrinogen deficiency , 1997-
Functional analysis for dysfibrinogenemia
Keywords:dysfibrinogenemia , 1993-
Academic Societies
Academic Societies
Japanese Society of LaboratoryMedicine
Japanese Societ of Clinical Chemistry
Japanese Society of Thrombosis and Hematostasis
Japanese Society of Laboratory Hematology
Japanese Society of Laboratory Automation
International Fibrinogen Research Society
International Society for Thrombosis and Haemostasis
Academic Background
College
Science University of Tokyo , (Faculty of Science) , 1982
School of Allied Medical Sciences, Shinshu University , 1977

Degree
Ph.D. , Shinshu University

Research

Books, Articles, etc.
Articles
γD318Y fibrinogen shows no fibrin polymerization due to defective “A-a” and “B-b” interactions, whereas that of γK321E fibrinogen is nearly normal
Thromb Res,182:150-158 2019
Author:KamijoT, Mukai S, Taira C, Higuchi Y, Okumura N.


Fibrin monomers derived from thrombogenic dysfibrinogenemia, Naples-type variant (BβAla68Thr), showed almost entirely normal polymerization
Thromb Res,172:1-3 2018
Author:Kamijo T, Nagata K, Taira C, Higuchi Y, Arai S, Okumura N


Hereditary Fibrinogen Aα-chain amyloidosis in Asia: clinical andmolecular characteristics.
Int. J. Mol. Sci.,19:320; doi:10.3390/ijms19010320 2018
Author:Yazaki M, Yoshinaga T, Sekijima Y, Kametani F, Okumura N.


The fibrous form of intracellular inclusion bodies in recombinant variant fibrinogen-producing cells is specific to the hapatic fibrinogen storage disease-inducible variant fibrinogen
Int J Hematol,105:758-768 2017(Jun. 30)
Author:Arai S, Ogiwara N, Mukai S, Takezawa Y, Sugano M, Honda T, Okumura N


A novel mutation in the fibrinogen Bβ chain (c.490G>A; End of Exon 3) causes a splicing abnormality and ultimately leads to congenital hypofibrinogenemia
Int. J. Mol. Sci,18:2470(doi:10.3390/ijms18112470) 2017
Author:Taira C, Matsuda K, Arai S, Sugano M, Uehara T, Okumura N.


Congenital dysfibrinogenemia in a Japanese family with Fibrinogen Naples (BβAla68Thr) manifesting as superior sagittal sinus thrombosis
Blood Coag Fibrinolysis,28:580-584 2017
Author:Yoshida S, Kibe T, Matsubara R, Koizumi S, Nara K, Amono K, Okumura N.


A novel frameshift mutation in the fibrinogen γC terminal region, FGG c.1169_1170 del AT, leading to hypofibrinogenemia.
Thromb Res,159:82-85 2017
Author:Nagata K, Arai S, Taira C, Sugano M, Honda T, Okumura N,


Hypodysfibrinogenemia with a heterozygous mutation of γCys326Ser by the novel transversion of TGT to TCT in a patient with pulmonary thromboembolism and right ventricular thrombus
Cardiology(Karger),137:167-172 2017
Author:Ushijima A, Komai T, Matsukawa A, Oikawa K, Morita N, Asai S, Mukai S, Okumura N, Kobayashi Y, Miyachi H.


Genetic analyses of novel compound heterozygous hypodysfibrinogenemia, Tsukuba I: FGG c.1129+62_65 del AATA and FGG c.1299+4 del A
Thromb Res,148:111-117 2016(Dec. 31)
Author:Mukai S, Nagata K, Ikeda M, Arai S, Sugano M, Honda T, Okumura N


Differences in the function and secretion of congenital aberrant fibrinogenemia between heterozygous gamma D320G (Okayama II) and gamma Delta N319-Delta D320 (Otsu I)
THROMBOSIS RESEARCH,136(6):1318-1324 2015(Dec.)
Author:Mukai, S; Ikeda, M; Takezawa, Y; Sugano, M; Honda, T; Okumura, N


Novel heterozygous dysfibrinogenemia, Sumida (A alpha C472S), showed markedly impaired lateral aggregation of protofibrils and mildly lower functional fibrinogen levels
THROMBOSIS RESEARCH,135(4):710-717 2015(Apr.)
Author:Ikeda, M; Arai, S; Mukai, S; Takezawa, Y; Terasawa, F; Okumura, N


Recombinant gamma T305A fibrinogen indicates severely impaired fibrin polymerization due to the aberrant function of hole 'a' and calcium binding sites
THROMBOSIS RESEARCH,134(2):518-525 2014(Aug.)
Author:Ikeda, M; Kobayashi, T; Arai, S; Mukai, S; Takezawa, Y; Terasawa, F; Okumura, N


γ375W fibrinogen-synthesizing CHO cells indicate the accumulation of variant fibrinogen within endoplasmic reticulum
THROMBOSIS RESEARCH,133(1):101-107 2014
Author:Kobayashi, T; Arai, S; Ogiwara, N; Takezawa, Y; Nanya, M; Terasawa, F; Okumura, N


Successdul living-related kidney transplantation in a boy with inherited dysfibrinogenemia
Pediatr Transplant,17:E161- E164 2013
Author:Imamura H, Akioka Y, Asano T, Sugawara N, Ishizuka K, Chikamoto H, Taki M, Terasawa F, Okumura N, Hattori M.


Nonsense-mediated mRNA decay was demonstrated in two hypofibrinogenemias caused by heterozygous nonsense mutations of FGG, Shizuoka III and Kanazawa II
Thromb Res,132:465-470 2013
Author:Soya K, Takezawa Y, Okumura N, Terasawa F


siRNA down-regulation of FGA mRNA in HepG2 cells demonstratedthat heterozygous abnormality of the Aalfa-chain gene does not affect the plasma fibrinogen level
Thrombosis Research,131:342-348 2013
Author:Takezawa Y, Matsuda K, Terasawa F, Sugano M, Honda T, Okumura N


Fibrinopeptide A release is necessary for effective B:b interactions in polymerization of variant fibrinogens with impaired A:a interactions
Thrombosis and Haemostasis,109:221-228 2013
Author:Soya K, Terasawa F, Okumura N


Molecular analysis of afibrinogenemic mutations caused by a homozygous FGA1238 bp deletion, and a compound heterozygous FGA1238 bpdeletion and novel FGA c.54+3A>C substitution
INTERNATIONAL JOURNAL OF HEMATOLOGY,96(1):39-46 2012(Jul.)
Author:Takezawa, Y; Terasawa, F; Matsuda, K; Sugano, M; Tanaka, A; Fujiwara, M; Kainuma, K; Okumura, N


Lateral medullary syndrome in a boy with hereditary dysfibrinogenemia
Brain and Development,34:857-860 2012
Author:Kibe T, Ikeya M. Yokochi K, Okumura N


Application of allele-specific quantitative PCR using genomic DNA to monitor minimal residual disease based on mutant gene levels following allogeneic hematopoietic stem cell transplantation in patients with hematological malignancies: Comparison of mutant levels with autologousDNA percentage by short tandem repeat-PCR.
Clinica Chimica Acta,413:516-519 2012
Author:Taira C, Matsuda K, Saito S, Sakashita K, Sugano M, Okumura N, Honda T.


Heterozygous Bβ C-terminal 12 amino acid-elongation variant,BβX462W (Kyoto VI), showed dysfibrinogenemia.
Blood Coagulation and Fibrinolysis,23(1):87-90 2012
Author:Okumura N , Terasawa F, Takezawa Y, Hirota-Kawadobora M, Inaba T, Fujita N, Saito M, Sugano M, Honda T.


フィブリノゲンの細胞内生成・分泌におけるBβ鎖D領域454-458残基の重要性
臨床病理,59:741-748 2011
Author:寺澤文子, 竹澤由夏, 廣田(川戸洞)雅子, 奥村伸生


Quantitative monitoring of single nucleotide mutation by allele-specific quantitative PCR can be used for assessment of minimal residual disease in patients with hematological malignancies throughout their clinical course.
Clinica Chimica Acta,412:53-58 2011
Author:Taira C, Matsuda K, Kamijyo Y, Sakashita K, Ishida F, Kumagai T, Yamauchi K, Okumura N, Honda T.


Spontaneous regression of the inhibitor against the coagulation factor XIII A subunit in acquired factor XIII deficiency.
Thrombosis and Haemostasis,104:1284-1285 2010
Author:Ishida F, Okubo K, Ito T, Okumura N, Souri M, Ichinose A.


A C-terminal amino acid substitution in the gamma-chain caused by a novel heterozygous frameshift mutation (Fibrinogen Matsumoto VII) results in hypofibrinogenaemia.
Thrombosis and Haemostasis,104(2):213-223 2010
Author:Fujihara N, Haneishi A, Yamauchi K, Terasawa F, Ito T, Ishida F, Okumura N.


In vitro transcription of compound heterozygous hypofibrinogenemia Matsumoto IX; first identification of FGB IVS6 deletion of 4 nucleotides and FGG IVS3-2A>G causing abnormal RNA splicing
Clinica Chimica Acta,411(17-18):1325-1329 2010
Author:Fumiko Terasawa, Yuka Kamijyo, Noriko Fujihara, Kazuyoshi Yamauchi, Toshiko Kumagai, Takayuki Honda, Satoshi Shigematsud and Nobuo Okumura


Analysis of plasmin generation and clot lysis of plasma fibrinogen purified from a heterozygous dysfibrinogenemia, betaGly15Cys (Hamamatsu II).
Blood Coagulation and Fibrinolysis,20(8):726-732 2009
Author:Kamijyo Y, Hirota-Kawadobora M, Yamauchi K, Terasawa F, Honda T, Ikeya M, Okumura N.


Impaired protofibril formation in fibrinogen gammaN308K is due to altered D:D and “A:a” interactions.
Biochemistry,48:8656-8663 2009
Author:Bowley SR, Okumura N, Lord ST.


Recombinant variant fibrinogens substituted at residues gamma326Cys and gamma339Cys demonstrated markedly impaired secretion of assembled fibrinogen.
Thrombosis Research,124:368-372 2009
Author:HaneishiA, Terasawa F, Fujihara N, Yamauchi K, Okumura N, Katsuyama T.


Citrullinated fibrinogen shows defects in FPA and FPB release and fibrin polymerization catalyzed by thrombin.
Clinica Chimica Acta,401:119-123 2009
Author:Okumura N, Haneishi A, Terasawa F.


Polymerization-defective fibrinogen variant gammaD364A binds knob “A” peptide mimic
Biochemistry,37:8607-8613 2008
Author:Bowley SR, Merenbloom BK, Okumura N, Betts L, Heroux A, Gorkun OV, Lord ST


Sialic acid moiety of apolipoprotein E3 at Thr194affects its interaction with ?-amyloid1-42 peptides
Clinica Chimica Acta,388:123-129 2008
Author:Sugano M, Yamauchi K, Kawasaki K, Tozuka M, Fujita K, Okumura N, Ota H


B:b interactions are essential for polymerization of variant fibrinogens with impaired holes ‘a’
Journal of Thrombosis and Haemostasis,5:2352-2359 2007
Author:Okumura N, Terasawa F, Haneishi A,Fujihara N,Hirota-Kawadobora M, Yamauchi K, Ota H, Lord ST


In vitro expression of a-thalassaemia gene (IVS1-1G>C) reveals complete inactivation of the normal 5’splice site and alternative aberrant RNA splicing.
Annals of Clinical Biochemistry,44:573-578 2007
Author:Fujihara N, Yamauchi K, Hirota-Kawadobora M, Ishikawa S, Tozuka M, Ishii E, Katsuyama T, Okumura N, Taniguchi S


Co-localization of TFF2 with gland mucouscell mucin in gastric mucous cellsand in extracellular mucous gel adherent to normal and damaged gastric mucosa
HISTOCHEMISTRY AND CELL BIOLOGY,126:617-625 2006
Author:Ota, H; Hayama, M; Momose, M; El-Zimaity, HMT; Matsuda, K; Sano, K; Maruta, F; Okumura, N; Katsuyama, T


An immunoglobulin A1 that inhibits lactate dehydrogenaseactivity, with reversal of inhibition by addition of NADH
Annals of Clinical and Laboratory Science,36:461-468 2006
Author:Fujita K, Sato H, Kameko F, Terasawa F, Okumura N, Sugano M, Yamauchi K, Maekawa M, Sakurabayashi I.


Invitro fibrin clot formation and fibrinolysis using heterozygous plasma fibrinogen from gAsn319,Asp320 deletion dysfibrinogen, Otsu I.
Thrombosis Research,118:651-661 2006
Author:Terasawa F, Kani S, Hongo M, Okumura N.


Analysis of fibrinogen variants at gamma 387Ile shows that the side chain of gamma 387 and the tertiary structure of the gamma C-terminal tail are important not only for assembly and secretion of fibrinogen but also for lateral aggregation of protofibrils and XIIIa-catalyzed gamma-gamma dimer formation
BLOOD,108:1887-1894 2006
Author:Kani, S; Terasawa, F; Yamauchi, K; Tozuka, M; Okumura, N


Mechanism of IgA-albumin complex formation that affectsthe fructosamine assay
Journal of Electrophoresis,50:19-23 2006
Author:Fijita K, Kameko F, Kato Y, Fukushima M, Okumura N, Terasawa F, Sugano M, YamauchiK, Sato H, Kameko M, Sakurabayashi I.


A novel variant fibrinogen, deletion of B beta 111Ser in coiled-coil region, affecting fibrin lateral aggregation
CLINICA CHIMICA ACTA,365:160-167 2006
Author:Okumura, N; Terasawa, F; Hirota-Kawadobora, M; Yamauchi, K; Nakanishi, K; Shiga, S; Ichiyama, S; Saito, M; Kawai, M; Nakahata, T


In vitro expression demonstrates impaired secretion of the gammaAsn 319, Asp320 deletion variant fibrinogen
Thromb Haemost,94:53-59 2005
Author:Kani S, Terasawa F, Lord ST, Tozuka M, Ota H, Okumura N, Katsuyama T


Functional analysis of recombinant Bbeta15C and Bbeta15A fibrinogens demonstrates that Bbeta15G residue plays important roles in FPB release and in lateral aggregation of protofibrils
Journal of Thrombosis and Haemostasis,3:983-990 2005
Author:M.Hirota-Kawadobora, S.Kani, F.Terasawa, N.Fujihara, K.Yamauchi, M.Tozuka, N.Okumura


Residue gamma153Cys is essential for the formationof the complexes Aalpha-gamma and Bbeta-gamma, assembly intermediates for the Aalpha-Bbeta-gamma complex and intact fibrinogen
Clinica Chimica Acta,353:157-164 2005
Author:Fumiko Terasawa, Kiyotaka Fujita, Nobuo Okumura


Characterization of factor XII Tenri, a rare CRM-negative factor XII deficiency
Annals of Clinical and Laboratory Science,34:218-225 2004
Author:Noriko Fijihara, Minoru Tozuka, Kazuyoshi Yamauchi, Ichiro Ueno, Nobuyuki Urasawa, Shinsuke Ishikawa, Masako Hirota-Kawadobora, Nobuo Okumura, Hiroya Hidaka, Tsutomu Katsuyama


Comparison of thrombin-catalyzed fibrin polymerization and factor XIIIa-catalyzed cross-linking of fibrin among three recombinant variant fibrinogens, gamma275C, gamma275H, and gamam275A
Journal of Thrombosis and Haemostasis,2:1359-1367 2004
Author:M.Hirota-Kawadobora, F.Terasawa, T.Suzuki, M.Tozuka, K.Sano, N.Okumura


Substitution of the gamma-chain Asn308 disturbs the D:D interface affecting fibrin polymerization, fibrinopeptide B release, and FXIIIa-catalyzed cross-linking
Blood,103:4157-4163 2004
Author:Nobuo Okumura, Oleg V. Gorkun, Fumiko Terasawa, Susan T. Lord


Recombinant fibrinogen, gamma275Arg->Cys, exhibits formation of disulfide bond with cysteine and severely impaired D:D interactions
Journal of Thrombosis and Haemostasis,2:468-475 2004
Author:S.Ishikawa, M.Hirota-Kawadobora, M.Tozuka, K.Ishii, F.Terasawa, N.Okumura


The Aalpha-chain 6Ile/Val polymorphism is not associated with plasma fibrinogen levels in Japanese
Thrombosis Research,112:257-259 2003
Author:Fumiko Terasawa, Masako Hirota-Kawadobora, Hikaru Kobayashi, Hiroshi Saito, Minoru Tozuka, Nobuo Okumura


Sequence gamam377-395(P2), but not gamma190-202(P1),is the binding site for the alphaMI-domain of integrin alphaMbeta2 inthe gammaC-domain of fibrinogen
Biochemistry,42:9365-9373 2003
Author:Tatiana P. Ugarova, Valeryi K. Lishko, Nataly P. Podolnikova, Nobuo Okumura, et al (5)


Novel beta-thalassemia trait (IVS I-1 G->C) in a Japanese family
American Journal of Hematology,72:64-66 2003
Author:Noriko Fijihara, Minoru Tozuka, Ichiro Ueno, Kazuyoshi Yamauchi, Ritsuko Nakagoshi, Shinsuke Ishikawa, Masako Hirota, Nobuo Okumura, Eizaburo Ishii, Tsutomu Katsuyama


Serotonin receptor antagonist inhibits monocrotaline-induced pulmonary hypertension and prolongs survival in rats
Cardiovascular Research,60:692-699 2003
Author:Hironaka E, Hongo M, Sakai A, Mawatari E, Ushiyama Y, Terasawa F, Okumura N,Yamazaki A, Yazaki Y, Kinoshita O, Kubo


Identification and properties of glycated monoclonal IgA that Affect the fructosamine assay.
Clinical Chemistry,49:805-808 2003
Author:Fujita K, Curtiss LK, Sakurabayashi I, Kameko F, Okumura N, Terasawa F, Tozuka M, Katsuyama


Fibrinogen Otsu I: A γAsn319, Asp320 deletiondysfibrinogen identified in an asymotomatic pregnant woman.
Thrombosis and Haemostasis,90:757-758 2003
Author:Terasawa F, Hogan KA, Kani S, Hirose M, Eguchi Y, Noda Y, Hongo M, Okumura N


Immunohistochemical lacalization of sodium-potassium ATPase in human normal stomach and gastric adenocarcinomas.
Histochem Cell Biol,119:317-322 2003
Author:Kobayashi C, Hayama M, Harada O, Terasawa F, Okumura N, Sugiyama A, Ota H


Fibrinogens Kosai and Ogasa: Bβ15Gly-Cys(GGT-TGT) substitution associated with impairment of fibrinopeptide B release and lateral aggregation.
J Thrombosis and Haemostasis,1:275-283 2003
Author:Hirota-Kawadobora M, Terasawa F, Yonekawa O, Sahara N, Shimizu E, Okumura N, Katsuyama T, Shigematsu


Evidence that heterodimers exist in the fibrinogenMatsumoto II (γ308N-K) proband and participate infibrin fiber formation.
Thrombosis Reseach,107:157-162 2002
Author:Okumura N, Terasawa F, Kiyotaka Fujita, Noriko Fujiwara, Minoru Tozuka, Chang-Sung Koh


Quantitative RT-PCR analysis demonstrates that synthesis of the recombinant fibrinogen is dependent on the transcription and synthesis of g-chain
Clinica Chimica Acta,319:67-73 2002
Author:Hirota-Kawadobora M, Tozuka M, Yamauchi K,Hidaka E, Ueno I, Sugano M, Terasawa F, Okumura N,Katuyama T, Shigematsu H


Analysisof fibrinogen gamma-chain truncations shows the C-terminus, particularly gammaIle387, is essential for assembly and secretion of this multichain protein
Blood,99:3654-3660 2002
Author:Okumura N, Terasawa F, Tanaka H, Hirota M, Ota H, Kitano K, Kiyosawa K, Lord ST


Predominant apolipoprotein J exists as lipid-poor mixtures in cerebrospinal fluid
Ann Clin Lab Sci,32:369-376 2002
Author:Suzuki T, Tozuka M, Kazuyoshi Y, Sugano M, Nakabayashi T, Okumura N, Hidaka H, Katsuyama T, Higuchi K


Hypofibrinogenemia associated with a heterozygous C->T nucleotide substitution at position -1138 bp of the 5'-flanking region of the fibrinogen Aα-chain.
Annals of New York Academy of Science,936:526-530 2001
Author:Okumura N, Terasawa F, Yonekawa O, Hamada E, Kaneko H


The formation of β fibrin requires a functional a site.
Annals of New York Academy of Science,936:219-222 2001
Author:Hogan KA, Bolliger B, Okumura N, Lord ST


Polymerization site a function dependence on structural integrity of its nearby calcium binding site.
Annals of New York Academy of Science,936:205-209 2001
Author:Lounes KC, Okumura N, Hogan KA, Ping L, Lord ST


Fibrinogen Matsumoto V: a variant with Aα19 Arg->Gly(AGG->GGG). Comparison between fibrin polymerization stimulated by thrombin or reptilase and fibrin monomer polymerization.
Thrombosis and Haemostasis,85:108-113 2001
Author:Tanaka H, Terasawa F, Ito T,Tokunaga S, Ishida F, Kitano K, Kiyosawa K, Okumura N


Analysis of hemoglobin and globin chain variants by a commonly used capillary isoelectric focusing method.
Electrophoresis,21(14):3016-3019 2000
Author:Sugano M, Hidaka H, Yamauchi K, Nakabayahsi T, Higuchi Y, Fujita K, Okumura N, Ushiyama Y, Tozuka M, Katsuyama T


Identification of a dysfibrinogen, the substitution of γ308Asn(AAT) to Lys(AAG), using coagulation tests, immunoblot analysis, and allele-specific polymerase chain reaction.
Clinica Chimica Acta,295(1-2):77-85 2000
Author:Terasawa F, Fujita K, Tozuka M, Ota H, Katsuyama T, Okumura N


A functional assay suggests that heterodimers exist in two C-terminal γ-chaindysfibrinogens; Matsumoto I and Vlissingen/Frankfurt IV.
Thrombosis and Haemostasis,83(4):592-597 2000
Author:Hogan KA, Lord ST, Okumura N, Terasawa F, Galanakis DK, Scharrer I, Gorkun OV


Difference in electrophoretic mobility and plasmic digestion profile between four recombinant fibrinogens, gamma 308K, gamma 308I, gamma 308A, and wild type (gamma 308N)
ELECTROPHORESIS,21(12):2309-2315 2000
Author:Okumura, N; Terasawa, F; Fujita, K; Tozuka, M; Ota, H; Katsuyama, T


Genetic analyses in homozygous and heterozygous variant of lactate dehydrogenese-B(H) subunit-LD-B Matsumoto I and II (LD-B W323R)-.
Clinica Chimica Acta,287(1-2):163-171 1999
Author:Okumura N, Terasawa F, Ueno I, Oki K, Yamauchi K, Hidaka H, Tozuka M, Okura M, Katsuyama T


Fibrinogen Matsumoto III: a variant with γ275Arg→Cys(CGC→TGC) -comparison of fibrin polymerization with those of Matsumoto I (γ364Asp→His) and Matsumoto II (γ308Asn→Lys).
Thrombosis and Haemostasis,81(5):763-766 1999
Author:Terasawa F, Okumura N,Higuchi Y, Ishikawa S, Tozuka M, Kitano K, Katsuyama T


Hypofibrinogenemia associated with a heterozygous missense mutation γ153Cys to Arg (Matsumoto IV): In vitro expression demonstrates defective secretion of the variant fibrinogen.
Blood,94(12):4122-4131 1999
Author:Terasawa F, Okumura N, Kitano K, Hayashida N, Shimosaka M, Okazaki M, Lord ST


Fibrinogen Matsumoto IV: A heterozygous fibrinogen deficiency caused by a missense mutation ofr153Cys toArg
THROMBOSIS AND HAEMOSTASIS,:42-42 1999
Author:Terasawa, F; Okumura, N; Lord, ST


Comparison of functions between recombinant variant fibrinogens, r308K, r308I and r308A
THROMBOSIS AND HAEMOSTASIS,:321-321 1999
Author:Okumura, N; Terasawa, F; Lord, ST


Flow Cytometryを用いた血小板活性化能測定の基礎的検討とその評価法
臨床病理,46:605-610 1998
Author:石川伸介, 戸塚 実, 廣田雅子, 佐々木由美子, 奥村伸生, 降旗謙一, 勝山 努


PlasminogenKanagawa-I, a novel missense mutation, is caused by the amino acid substitution G732R
British J of Haematology,103(3):867-870 1998
Author:Higuchi Yumiko, Furihata Kenichi, Ueno Ichiro, Ishikawa Shinshuke, Okumura Nobuo, Tozuka Minoru, Sakurai Noriko


Characterization of hypertriglyceridemia induced by L-asparaginase therapy for acute lymphoblastic leukemia and malignant lymphoma
ANNALS OF CLINICAL AND LABORATORY SCIENCE,27(5):351-357 1997
Author:Tozuka, M; Yamauchi, K; Hidaka, H; Nakabayashi, T; Okumura, NS; Katsuyama, T


Megakaryocytes derived from CD34-positive cord blood cells produce interleukin-8
BRITISH JOURNAL OF HAEMATOLOGY,99(3):509-516 1997
Author:Higuchi, T; Koike, K; Sawai, N; Mwamtemi, HH; Takeuchi, K; Shiohara, M; Kikuchi, T; Yasui, K; Ito, S; Yamagami, O; Sasaki, Y; Okumura, N; Kato, T; Miyazaki, H; Ikeda, M; Yamada, M; Komiyama, A


Aberrant growth of granulocyte-macrophage progenitors in juvenile chronic myelogenous leukemia in serum-free culture
EXPERIMENTAL HEMATOLOGY,24(2):116-122 1996
Author:Sawai, N; Koike, K; Ito, S; Okumura, N; Kamijo, T; Shiohara, M; Amano, Y; Tsuji, K; Nakahata, T; Oda, M; Okamura, J; Kobayashi, M; Komiyama, A


Influence of apolipoprotein E phenotypes on total serum cholesterol in Japanese children
CLINICA CHIMICA ACTA,247(1-2):175-180 1996
Author:Tozuka, M; Ohta, H; Hidaka, H; Okumura, N; Furihata, K; Katsuyama, T


Chemotactic and chemokinetic activities of stem cell factor on murine hematopoietic progenitor cells
BLOOD,87(10):4100-4108 1996
Author:Okumura, N; Tsuji, K; Ebihara, Y; Tanaka, I; Sawai, N; Koike, K; Komiyama, A; Nakahata, T


Fibrinogen Matsumoto I: A gamma 364 Asp->His (GAT->CAT) substitution associated with defective fibrin polymerization
THROMBOSIS AND HAEMOSTASIS,75(6):887-891 1996
Author:Okumura, N; Furihata, K; Terasawa, F; Nakagoshi, R; Ueno, I; Katsuyama, T


A case of immunoglobulin A-lambda conjugated with lactate dehydrogenase-5 isoenzyme, causing an extremely high enzyme activity in serum
CLINICAL CHEMISTRY,42(8):1288-1290 1996
Author:Tozuka, M; Hidaka, H; Okumura, N; Ichikawa, T; Furibata, K; Katsuyama, T


Fibrinogen Matsumoto II: gamma(308)Asn->Lys(AAT->AAG) mutation associated with bleeding tendency
BRITISH JOURNAL OF HAEMATOLOGY,94(3):526-528 1996
Author:Okumura, N; Furihata, K; Terasawa, F; Ishikawa, S; Ueno, I; Katsuyama, T


PREVENTION OF HEPATIC-ARTERY THROMBOSIS IN PEDIATRIC LIVER-TRANSPLANTATION
TRANSPLANTATION,60(10):1109-1112 1995
Author:HASHIKURA, Y; KAWASAKI, S; OKUMURA, N; ISHIKAWA, S; MATSUNAMI, H; IKEGAMI, T; NAKAZAWA, Y; MAKUUCHI, M


Fibrinogen Matsumoto II: A gamma 308ASN->Lys(AAT->AAG) mutation associated with defective fibrin polymerization.
BLOOD,86(10):3520-3520 1995
Author:Okumura, N; Terasawa, F; Ueno, I; Kaysuyama, T; Furihata, K


CELL-SURFACE ANTIGEN EXPRESSION IN HUMAN ERYTHROID PROGENITORS - ERYTHROID AND MEGAKARYOCYTIC MARKERS
LEUKEMIA&LYMPHOMA,13(5-6):401-409 1994
Author:NAKAHATA, T; OKUMURA, N


GENETIC-ANALYSIS OF FIBRINOGEN MATSUMOTO - A POINT MUTATION IN EXON-9 OF GAMMA-CHAIN RESPONSIBLE FOR DEFECTIVE FIBRIN POLYMERIZATION
BLOOD,84(10):A60-A60 1994
Author:TERASAWA, F; OKUMURA, N; UENO, I; HIDAKA, E; FURUWATARI, C; YAN, J; KATSUYAMA, T; FURIHATA, K


CHANGES IN CELL-SURFACE ANTIGEN EXPRESSIONS DURING PROLIFERATION AND DIFFERENTIATION OF HUMAN ERYTHROID PROGENITORS
EXPERIMENTAL HEMATOLOGY,20(6):793-793 1992
Author:OKUMURA, N; NAKAHATA, T


CHANGES IN CELL-SURFACE ANTIGEN EXPRESSIONS DURING PROLIFERATION AND DIFFERENTIATION OF HUMAN ERYTHROID PROGENITORS
BLOOD,80(3):642-650 1992
Author:OKUMURA, N; TSUJI, K; NAKAHATA, T


COAGULATION ABNORMALITIES FOLLOWED ORTHOTOPIC LIVING RELATED LIVER-TRANSPLANTATION
THROMBOSIS AND HAEMOSTASIS,65(6):1090-1090 1991
Author:SAITO, H; OKUMURA, N; HARADA, H; KUDO, M; MAKUUCHI, M; FURUTA, S


INTERLEUKIN-6 SUPPORTS HUMAN MEGAKARYOCYTIC PROLIFERATION AND DIFFERENTIATION INVITRO
BLOOD,78(8):1969-1974 1991
Author:IMAI, T; KOIKE, K; KUBO, T; KIKUCHI, T; AMANO, Y; TAKAGI, M; OKUMURA, N; NAKAHATA, T

Themes for Joint Research
Clinical Laboratory Science , Clinical Chemistry
Fibrinogen, Fibrin , Thrombosis, Haemostasis
Citrullinated fibrinogen・fibrin and their autoantibody , Clinical Immunology
Research Grants
Grants‐in‐aid for Scientific Research(Research Representative)
2017 - 2019 , フィブリノゲン機能異常症例の解析からフィブリン重合機序の詳細を解明する研究 , 基盤研究(C)
2014 - 2016 , 肝硬変を引き起こすフィブリノゲン低下症の鑑別法の開発と分子生物学的発生機序解明 , 基盤研究C
2010 - 2012 , シトルリン化フィブリノゲン・フィブリンの溶解性に関する研究 , 基盤(C)
2007 - 2008 , シトルリン化フィブリノゲンの凝固・線溶機能異常とその病因との関係 , 基盤研究(C)
2004 - 2006 , フィブリノゲンの組み立て・分泌におけるBb鎖・g鎖の機能の相違に関する研究 , 基盤研究(C)

Grants‐in‐aid for Scientific Research(Researcher)
2013 - 2015 , 血漿および関節液中のシトルリン化フィブリノゲンとその抗体定量法の確立. , 科学研究費 基盤研究C

Other
2006 - 2007 , リコンビナントフィブリノゲンを用いたフィブリノゲン-フィブリン転換の分子メカニズムの解析とその正常機能を抑制する合成ペプチドの検索
2002 - 2002 , リコンビナントヒト正常・異常フィブリノゲンを用いたフィブリン繊維形成機序の解析と合成ペプチドによるその抑制
1998 - 1999 , 異常フィブリノゲンMataumotoIVの遺伝子導入による原因の研究
1997 - 1997 , リコンビナント異常フィブリノゲンを用いたフィブリン凝集能の解析
Research Activities
Journal Editorial Board
2003- , Clinica Chimica Acta (Editorial Board)
2008-2011 , 臨床病理(編集委員)

Overseas Research Fellowship
1996-1997 , 長期在外研究員(乙) , The University of North Carolina

Guest Researchers
2003-2003 , 日本学術振興会外国人招へい研究者(短期) , Professor of The University of North Carolina