
TANAKA Naoki
Academic Assembly School of Medicine and Health Sciences Institute of Medicine
School of Medicine Department of Medicine
Professor
Researcher Information
Research Keyword
- NASH, NASH, Nuclear receptor, PPAR, Metabolic syndrome, Adipocyte, Hepatology, Metabolic syndrome, Obesity, Toxicology
Field Of Study
TEL
- +81-263-37-2354
Career
- 2022
Shinshu University Graduate School of Medicine, Department of Global Medical Research Promotion, Professor - 2021
Shinshu University School of Medicine, International Relations Office, Professor - 2014
Associate Professor, Department of Metabolic Regulation, Shinshu University Graduate School of Medicine - 2009 - 2012
Assistant Professor, Department of Metabolic Regulation, Shinshu University Graduate School of Medicine - 2006 - 2009
Assistant Professor, Department of Metabolic Regulation, Shinshu University Graduate School of Medicine - 2005 - 2006
Medical Staff in Gastroenterology, Shinshu University Hospital - 2003 - 2005
Medical Staff in Internal Medicine, Showa Inan General Hospital - 2002 - 2003
Medical Staff in Gastroenterology, Shinshu University Hospital - 1995 - 1996
Resident in Internal Medicine, Shinshu University Hospital
Educational Background
Research activity information
Award
- 2020
第23回日本病態栄養学会年次学術集会 若手研究会長賞
Japan
第23回日本病態栄養学会年次学術集会 若手研究会長賞 - 2015
米国国立衛生研究所, The Fellows Award for Research Excellence in NIH
The Fellows Award for Research Excellence in NIH - 2014
米国国立衛生研究所, The Fellows Award for Research Excellence in NIH
The Fellows Award for Research Excellence in NIH - 2013
米国国立衛生研究所, The Fellows Award for Research Excellence in NIH
The Fellows Award for Research Excellence in NIH - 2010
第23回日本消化器病学会奨励賞
Japan
第23回日本消化器病学会奨励賞 - 2009
信州大学医学部松医会賞基礎分野
Japan
信州大学医学部松医会賞基礎分野 - 2008
日本肝臓学会第7回Schering-Plough Award基礎分野優秀賞
Japan
日本肝臓学会第7回Schering-Plough Award基礎分野優秀賞 - 2007
ウイルス肝炎研究財団 研究助成
ウイルス肝炎研究財団 研究助成
Paper
- Prognostic Significance of Bile Duct Loss in Early-Stage Primary Biliary Cholangitis: A Long-Term Observational Study.
Taiki Okumura; Takefumi Kimura; Takanobu Iwadare; Shun-Ichi Wakabayashi; Hiroyuki Kobayashi; Yuki Yamashita; Satoru Joshita; Michiharu Komatsu; Naoki Tanaka; Akihiro Matsumoto; Tomoyuki Nakajima; Mai Iwaya; Masahiro Umemura; Kazuhito Kawata; Kenichi Harada; Takeji Umemura
Hepatology research : the official journal of the Japan Society of Hepatology, Aug. 2025, Refereed - Multi-omics analysis of diabetic cardiomyopathy pathogenesis using a type 2 diabetic Zucker diabetic fatty rat model.
Kazuhiro Tanabe; Qianqian Zheng; Xuguang Zhang; Naoki Tanaka; Chihiro Hayashi; Asaka Yokota; Rina Otsuka; Tomoko Katahira; Motoyuki Kohjima; Makoto Nakamuta
Scientific reports, 15(1), 22797-22797, Jul. 2025, Refereed - Thrombospondin 2 as a Predictive Biomarker for HCC in Hepatitis C Patients: A Longitudinal Study Following DAA Therapy.
Takanobu Iwadare; Takefumi Kimura; Ayumi Sugiura; Taiki Okumura; Shun-Ichi Wakabayashi; Hiroyuki Kobayashi; Yuki Yamashita; Tomoo Yamazaki; Satoru Joshita; Naoki Tanaka; Takeji Umemura
Journal of viral hepatitis, 32(4), e14025, Apr. 2025, Refereed - AI-Based Platelet-Independent Noninvasive Test for Liver Fibrosis in MASLD Patients.
Shun-Ichi Wakabayashi; Takefumi Kimura; Nobuharu Tamaki; Takanobu Iwadare; Taiki Okumura; Hiroyuki Kobayashi; Yuki Yamashita; Naoki Tanaka; Masayuki Kurosaki; Takeji Umemura
JGH open : an open access journal of gastroenterology and hepatology, 9(4), e70150, Apr. 2025, Refereed - Dietary Polyunsaturated Fatty Acid Deficiency Impairs Renal Lipid Metabolism and Adaptive Response to Proteinuria in Murine Renal Tubules.
Yaping Wang; Pan Diao; Daiki Aomura; Takayuki Nimura; Makoto Harada; Fangping Jia; Takero Nakajima; Naoki Tanaka; Yuji Kamijo
Nutrients, 17(6), Mar. 2025, Refereed - Colorectal Cancer Incidence in Steatotic Liver Disease (MASLD, MetALD, and ALD).
Takefumi Kimura; Nobuharu Tamaki; Shun-Ichi Wakabayashi; Naoki Tanaka; Takeji Umemura; Namiki Izumi; Rohit Loomba; Masayuki Kurosaki
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, Jan. 2025, Refereed - Comparison of Free Flavonoids and the Polyphenol Content in the Bran of a Newly Developed Sorghum Variety and Two Commercially Available Sorghum Varieties.
Mariely Cristine Dos Santos; Naoki Tanaka; Shigemitsu Kasuga; Kazuhiro Tanabe; Chihiro Hayashi; Masahiro Mizuno; Yoshihiko Amano
Metabolites, 14(11), Nov. 2024, Refereed - Circulating thrombospondin 2 as a predictor of hepatocellular carcinoma in hepatitis B patients undergoing nucleos(t)ide analog therapy.
Taiki Okumura; Takefumi Kimura; Yuki Ichikawa; Takanobu Iwadare; Shun-Ichi Wakabayashi; Hiroyuki Kobayashi; Yuki Yamashita; Takuro Uchida; Sai P Pydi; Naoki Tanaka; Takeji Umemura
Scientific reports, 14(1), 25584-25584, Oct. 2024, Refereed - Serum autotaxin is a prognostic indicator of liver-related events in patients with non-alcoholic fatty liver disease.
Takanobu Iwadare; Takefumi Kimura; Taiki Okumura; Shun-Ichi Wakabayashi; Taro Nakajima; Shohei Kondo; Hiroyuki Kobayashi; Yuki Yamashita; Ayumi Sugiura; Naoyuki Fujimori; Tomoo Yamazaki; Hideo Kunimoto; Satoshi Shimamoto; Koji Igarashi; Satoru Joshita; Naoki Tanaka; Takeji Umemura
Communications medicine, 4(1), 73-73, Apr. 2024, Refereed - Predictive Insights Into Exocrine Pancreatic Insufficiency in Chronic Pancreatitis and Autoimmune Pancreatitis: A Decision Tree Approach.
Tomoyuki Tanaka; Takefumi Kimura; Shun-Ichi Wakabayashi; Takuma Okamura; Shohei Shigeto; Naoki Tanaka; Shohei Kondo; Ichitaro Horiuchi; Yasuhiro Kuraishi; Akira Nakamura; Norihiro Ashihara; Keita Kanai; Tadanobu Nagaya; Takayuki Watanabe; Takeji Umemura
Pancreas, 53(3), e227-e232, Mar. 2024, Refereed - Thrombospondin 2 is a key determinant of fibrogenesis in non-alcoholic fatty liver disease.
Takefumi Kimura; Takanobu Iwadare; Shun-Ichi Wakabayashi; Seema Kuldeep; Tomoyuki Nakajima; Tomoo Yamazaki; Daiki Aomura; Hamim Zafar; Mai Iwaya; Satoru Joshita; Takeshi Uehara; Sai P Pydi; Naoki Tanaka; Takeji Umemura
Liver international : official journal of the International Association for the Study of the Liver, 44(2), 483-496, Feb. 2024, Refereed - Investigation of Clinical Features and Association between Vascular Endothelial Injury Markers and Cytomegalovirus Infection Associated with Thrombotic Microangiopathy in Patients with Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis: Case-Based Research.
Takayuki Nimura; Daiki Aomura; Makoto Harada; Akinori Yamaguchi; Kosuke Yamaka; Takero Nakajima; Naoki Tanaka; Takashi Ehara; Koji Hashimoto; Yuji Kamijo
International journal of molecular sciences, 25(2), Jan. 2024, Refereed - Long-Term pemafibrate treatment exhibits limited impact on body fat mass in patients with hypertriglyceridemia accompanying NAFLD.
Takanobu Iwadare; Takefumi Kimura; Hideo Kunimoto; Taiki Okumura; Shun-Ichi Wakabayashi; Hiroyuki Kobayashi; Yuki Yamashita; Ayumi Sugiura; Naoki Tanaka; Takeji Umemura
Frontiers in endocrinology, 15, 1329294-1329294, 2024, Refereed - An orally deliverable ornithine-based self-assembling polymer nanomedicine ameliorates hyperammonemia in acetaminophen-induced acute liver injury.
Yuanyuan Ding; Yuta Koda; Babita Shashni; Naoki Takeda; Xuguang Zhang; Naoki Tanaka; Yuji Nishikawa; Yukio Nagasaki
Acta biomaterialia, 168, 515-528, Sep. 2023, Refereed - Establishment of Novel Mouse Model of Dietary NASH Rapidly Progressing into Liver Cirrhosis and Tumors.
Qianqian Zheng; Masaya Kawaguchi; Hayato Mikami; Pan Diao; Xuguang Zhang; Zhe Zhang; Takero Nakajima; Takanobu Iwadare; Takefumi Kimura; Jun Nakayama; Naoki Tanaka
Cancers, 15(14), Jul. 2023, Refereed
Last, Corresponding - Dietary Fat Composition Affects Hepatic Angiogenesis and Lymphangiogenesis in Hepatitis C Virus Core Gene Transgenic Mice.
Pan Diao; Yaping Wang; Fangping Jia; Xiaojing Wang; Xiao Hu; Takefumi Kimura; Yoshiko Sato; Kyoji Moriya; Kazuhiko Koike; Jun Nakayama; Naoki Tanaka
Liver cancer, 12(1), 57-71, Feb. 2023, Refereed
Last, Corresponding - Development of the Rabbit NASH Model Resembling Human NASH and Atherosclerosis.
Momoko Hayashi; Yoshibumi Kuwabara; Kuniji Ito; Yoshiaki Hojo; Fumiaki Arai; Kazuki Kamijima; Masakazu Takeiri; Xiaojing Wang; Pan Diao; Jun Nakayama; Naoki Tanaka
Biomedicines, 11(2), Jan. 2023, Refereed
Last, Corresponding - Circulating thrombospondin 2 levels reflect fibrosis severity and disease activity in HCV-infected patients.
Takanobu Iwadare; Takefumi Kimura; Naoki Tanaka; Tomoo Yamazaki; Shun-Ichi Wakabayashi; Taiki Okumura; Hiroyuki Kobayashi; Yuki Yamashita; Sai P Pydi; Tomoyuki Nakajima; Mai Iwaya; Ayumi Sugiura; Satoru Joshita; Takeshi Uehara; Takeji Umemura
Scientific reports, 12(1), 18900-18900, Nov. 2022, Refereed - Higher Responsiveness for Women, High Transaminase Levels, and Fat Percentage to Pemafibrate Treatment for NAFLD.
Takanobu Iwadare; Takefumi Kimura; Hideo Kunimoto; Naoki Tanaka; Shun-Ichi Wakabayashi; Tomoo Yamazaki; Taiki Okumura; Hiroyuki Kobayashi; Yuki Yamashita; Ayumi Sugiura; Satoru Joshita; Takeji Umemura
Biomedicines, 10(11), Nov. 2022, Refereed - Clinically Relevant Dose of Pemafibrate, a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα), Lowers Serum Triglyceride Levels by Targeting Hepatic PPARα in Mice.
Zhe Zhang; Pan Diao; Xuguang Zhang; Takero Nakajima; Takefumi Kimura; Naoki Tanaka
Biomedicines, 10(7), Jul. 2022, Refereed
Last, Corresponding - 2-Step PLT16-AST44 method: Simplified liver fibrosis detection system in patients with non-alcoholic fatty liver disease
Fujimori, Naoyuki; Kimura, Takefumi; Tanaka, Naoki; Yamazaki, Tomoo; Okumura, Taiki; Kobayashi, Hiroyuki; Wakabayashi, Shun-Ichi; Yamashita, Yuki; Sugiura, Ayumi; Pham, Jonathan; Pydi, Sai P.; Sano, Kenji; Joshita, Satoru; Umemura, Takeji
HEPATOLOGY RESEARCH, 52(4), 352-363, Apr. 2022, Refereed - Serum Sulfatide Levels as a Biomarker of Active Glomerular Lesion in Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Single Center Pilot Study
Harada, Makoto; Nakajima, Takero; Yamada, Yosuke; Aomura, Daiki; Yamaguchi, Akinori; Sonoda, Kosuke; Tanaka, Naoki; Hashimoto, Koji; Kamijo, Yuji
JOURNAL OF CLINICAL MEDICINE, 11(3), 762, Feb. 2022, Refereed - Acidic Activated Charcoal Prevents Obesity and Insulin Resistance in High-Fat Diet-Fed Mice.
Xuguang Zhang; Pan Diao; Hiroaki Yokoyama; Yoshiki Inoue; Kazuhiro Tanabe; Xiaojing Wang; Chihiro Hayashi; Tomoki Yokoyama; Zhe Zhang; Xiao Hu; Takero Nakajima; Takefumi Kimura; Jun Nakayama; Makoto Nakamuta; Naoki Tanaka
Frontiers in nutrition, 9, 852767-852767, 2022, Refereed
Last, Corresponding - Mechanisms of Steatosis-Derived Hepatocarcinogenesis: Lessons from HCV Core Gene Transgenic Mice
Diao, Pan; Jia, Fangping; Wang, Xiaojing; Hu, Xiao; Kimura, Takefumi; Nakajima, Takero; Aoyama, Toshifumi; Moriya, Kyoji; Koike, Kazuhiko; Tanaka, Naoki
ENGINEERING, 7(12), 1797-1805, Dec. 2021, Refereed
Last, Corresponding - Mucosal defect size predicts the adequacy of resection of <= 10 mm nonpedunculated colorectal polyps using a new cold snare polypectomy technique
Kudo, Takahiro; Horiuchi, Akira; Kyodo, Reiko; Tokita, Kazuhide; Tanaka, Naoki; Horiuchi, Ichitaro; Sano, Kenji
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 33, E484-E489, Dec. 2021, Refereed - Pemafibrate, a novel selective PPARα modulator, attenuates tamoxifen-induced fatty liver disease.
Naoki Tanaka; Kazutaka Mukaiyama; Akio Morikawa; Satoshi Kawakami; Yasuyuki Ichise; Takefumi Kimura; Akira Horiuchi
Clinical journal of gastroenterology, 14(3), 846-851, Jun. 2021, Refereed
Lead, Corresponding - Linked colour imaging versus white-light colonoscopy for the detection of flat colorectal lesions: A randomized controlled trial
Kudo, Takahiro; Horiuchi, Akira; Kyodo, Reiko; Horiuchi, Ichitaro; Arai, Nobuyasu; Kajiyama, Masashi; Tanaka, Naoki
COLORECTAL DISEASE, 23(6), 1414-1420, Jun. 2021, Refereed
Last - Risk of Gastrointestinal Endoscopic Procedure-Related Bleeding in Patients With or Without Continued Antithrombotic Therapy.
Kiyoaki Yabe; Akira Horiuchi; Takahiro Kudo; Ichitaro Horiuchi; Yasuyuki Ichise; Masashi Kajiyama; Naoki Tanaka
Digestive diseases and sciences, 66(5), 1548-1555, May 2021, Refereed - Serum thrombospondin 2 is a novel predictor for the severity in the patients with NAFLD
Kimura, Takefumi; Tanaka, Naoki; Fujimori, Naoyuki; Yamazaki, Tomoo; Katsuyama, Takahito; Iwashita, Yuichi; Pham, Jonathan; Joshita, Satoru; Pydi, Sai P.; Umemura, Takeji
LIVER INTERNATIONAL, 41(3), 505-514, Mar. 2021, Refereed - A saturated fatty acid-rich diet enhances hepatic lipogenesis and tumorigenesis in HCV core gene transgenic mice
Diao, Pan; Wang, Xiaojing; Jia, Fangping; Kimura, Takefumi; Hu, Xiao; Shirotori, Saki; Nakamura, Ibuki; Sato, Yoshiko; Nakayama, Jun; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Aoyama, Toshifumi; Tanaka, Naoki
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 85, Nov. 2020, Refereed
Last, Corresponding - Invasive liver abscess syndrome accompanied by spondylodiscitis: a case report and review of the literature
Wakabayashi SI, Kimura T, Tanaka N, Pham J, Tanaka T, Higuchi S, Kobayashi J, Umemura T, Iijima A.
Clin J Gastroenterol, 13(5), 927-934, Oct. 2020, Refereed - Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice
Jia, Fangping; Diao, Pan; Wang, Xiaojing; Hu, Xiao; Kimura, Takefumi; Nakamuta, Makoto; Nakamura, Ibuki; Shirotori, Saki; Sato, Yoshiko; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Nakayama, Jun; Aoyama, Toshifumi; Tanaka, Naoki
LIVER CANCER, 9(5), 529-548, Sep. 2020, Refereed
Last, Corresponding - Polyunsaturated fatty acid deficiency affects sulfatides and other sulfated glycans in lysosomes through autophagy-mediated degradation
Wang, Yaping; Nakajima, Takero; Diao, Pan; Yamada, Yosuke; Nakamura, Kozo; Nakayama, Jun; Tanaka, Naoki; Aoyama, Toshifumi; Kamijo, Yuji
FASEB JOURNAL, 34(7), 9594-9614, Jul. 2020, Refereed - Congestive hepatopathy and acute pancreatitis as severe complications of mixed connective tissue disease
Kurihara S, Kimura T, Tanaka N, Yanagisawa T, Kobayashi H, Kanai K, Umemura T, Kobayashi M, Mori H, Wada S.
Clin J Gastroenterol, 13(3), 434-442, Jun. 2020, Refereed - Long-term luseogliflozin therapy improves histological activity of non-alcoholic steatohepatitis accompanied by type 2 diabetes mellitus
Fujimori N, Tanaka N, Kimura T, Sano K, Horiuchi A, Kato N, Takahashi Y, Kuribayashi N, Sugiura A, Yamazaki T, Joshita S, Umemura T, Matsumoto A, Tanaka E.
Clin J Gastroenterol, 13(1), 83-89, Feb. 2020, Refereed
Corresponding - A trans-fatty acid-rich diet promotes liver tumorigenesis in HCV core gene transgenic mice
Hu, Xiao; Wang, Xiaojing; Jia, Fangping; Tanaka, Naoki; Kimura, Takefumi; Nakajima, Takero; Sato, Yoshiko; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Nakayama, Jun; Aoyama, Toshifumi
CARCINOGENESIS, 41(2), 159-170, Feb. 2020, Refereed
Corresponding - A high-cholesterol diet promotes steatohepatitis and liver tumorigenesis in HCV core gene transgenic mice
Wang, Xiaojing; Tanaka, Naoki; Hu, Xiao; Kimura, Takefumi; Lu, Yu; Jia, Fangping; Sato, Yoshiko; Nakayama, Jun; Moriya, Kyoji; Koike, Kazuhiko; Aoyama, Toshifumi
ARCHIVES OF TOXICOLOGY, 93(6), 1713-1725, Jun. 2019, Refereed
Corresponding - Lipidomics reveal aryl hydrocarbon receptor (Ahr)-regulated lipid metabolic pathway in alpha-naphthyl isothiocyanate (ANIT)-induced intrahepatic cholestasis.
Bao-Long Wang; Chang-Wen Zhang; Liang Wang; Kun-Long Tang; Naoki Tanaka; Frank J Gonzalez; Yong Xu; Zhong-Ze Fang
Xenobiotica; the fate of foreign compounds in biological systems, 49(5), 591-601, May 2019 - Safety and Effectiveness of Nurse-Administered Propofol Sedation in Outpatients Undergoing Gastrointestinal Endoscopy
Sato, Masamichi; Horiuchi, Akira; Tamaki, Michio; Ichise, Yasuyuki; Kajiyama, Masashi; Yamamoto, Yuta; Tanaka, Naoki
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 17(6), 1098-+, May 2019, Refereed
Last - Red plasma and ascites under ultraviolet A
Wakabayashi, Shun-ichi; Kimura, Takefumi; Tanaka, Naoki; Komatsu, Michiharu; Tanaka, Eiji
LANCET GASTROENTEROLOGY & HEPATOLOGY, 4(4), 324-324, Apr. 2019, Refereed - Peroxisome proliferator-activated receptor attenuates high-cholesterol diet-induced toxicity and pro-thrombotic effects in mice
Lu, Yu; Harada, Makoto; Kamijo, Yuji; Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Kyogashima, Mamoru; Gonzalez, Frank J.; Aoyama, Toshifumi
ARCHIVES OF TOXICOLOGY, 93(1), 149-161, Jan. 2019, Refereed, Not invited - Miglitol attenuates non-alcoholic steatohepatitis in diabetic patients
Komatsu, Michiharu; Tanaka, Naoki; Kimura, Takefumi; Fujimori, Naoyuki; Sano, Kenji; Horiuchi, Akira; Sugiura, Ayumi; Yamazaki, Tomoo; Shibata, Soichiro; Joshita, Satoru; Umemura, Takeji; Matsumoto, Akihiro; Tanaka, Eiji
HEPATOLOGY RESEARCH, 48(13), 1092-1098, Dec. 2018, Refereed, Not invited
Corresponding - Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development.
Takahashi S; Tanaka N; Fukami T; Xie C; Yagai T; Kim D; Velenosi TJ; Yan T; Krausz KW; Levi M; Gonzalez FJ
Hepatol Commun, 2(12), 1567-1582, Oct. 2018, Refereed, Not invited
Lead - Salmonella Enteritidis cholecystitis with chronic granulomatous disease.
Yamashita Y; Kimura T; Tanaka N; Yazaki M; Itagaki T; Joshita S; Umemura T; Matsumoto A; Mori H; Wada S; Tanaka E
IDCases, 12, 12:49-52, May 2018, Refereed, Not invited - Mild drinking habit is a risk factor for hepatocarcinogenesis in non-alcoholic fatty liver disease with advanced fbrosis
Takefumi Kimura; Naoki Tanaka; Naoyuki Fujimori; Ayumi Sugiura; Tomoo Yamazaki; Satoru Joshita; Michiharu Komatsu; Takeji Umemura; Akihiro Matsumoto; Eiji Tanaka
World Journal of Gastroenterology, 24(13), 1440-1450, Apr. 2018, Refereed, Not invited
Corresponding - Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non-alcoholic fatty liver disease
Naoyuki Fujimori; Takeji Umemura; Takefumi Kimura; Naoki Tanaka; Ayumi Sugiura; Tomoo Yamazaki; Satoru Joshita; Michiharu Komatsu; Yoko Usami; Kenji Sano; Koji Igarashi; Akihiro Matsumoto; Eiji Tanaka
World Journal of Gastroenterology, 24(11), 1239-1249, Mar. 2018, Refereed, Not invited - Growth arrest and DNA damage-inducible 45 alpha protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet
Naoki Tanaka; Shogo Takahashi; Xiao Hu; Yu Lu; Naoyuki Fujimori; Srujana Golla; Zhong-Ze Fang; Toshifumi Aoyama; Kristopher W. Krausz; Frank J. Gonzalez
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1863(12), 3170-3182, Dec. 2017, Refereed, Not invited
Lead - Cimetidine/lactulose therapy ameliorates erythropoietic protoporphyria-related liver injury
Fujimori N; Komatsu M; Tanaka N; Iwaya M; Nakano H; Sugiura A; Yamazaki T; Shibata S; Iwaya Y; Muraki T; Ichikawa Y; Kimura T; Joshita S; Umemura T; Matsumoto A; Tanaka E
Clin J Gastroenterol, 10(5), 452-458, Oct. 2017, Refereed, Not invited
Corresponding - Association between lower air pressure and the onset of ischemic colitis: a case-control study
Takefumi Kimura; Akihiro Shinji; Naoki Tanaka; Masayoshi Koinuma; Maki Yamaura; Tadanobu Nagaya; Satoru Joshita; Michiharu Komatsu; Takeji Umemura; Akira Horiuchi; Shuichi Wada; Eiji Tanaka
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 29(9), 1071-1078, Sep. 2017, Refereed, Not invited
Corresponding - Farnesoid X Receptor Protects Against Low-Dose Carbon Tetrachloride-Induced Liver Injury Through the Taurocholate-JNK Pathway
Shogo Takahashi; Naoki Tanaka; Srujana Golla; Tatsuki Fukami; Kristopher W. Krausz; Marianne A. Polunas; Blair C. Weig; Yusuke Masuo; Cen Xie; Changtao Jiang; Frank J. Gonzalez
TOXICOLOGICAL SCIENCES, 158(2), 334-346, Aug. 2017, Refereed, Not invited - Decreased Fatty Acid beta-Oxidation Is the Main Cause of Fatty Liver Induced by Polyunsaturated Fatty Acid Deficiency in Mice
Takero Nakajima; Yang Yang; Yu Lu; Yuji Kamijo; Yosuke Yamada; Kozo Nakamura; Masahiro Koyama; Shohei Yamaguchi; Eiko Sugiyama; Naoki Tanaka; Toshifumi Aoyama
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 242(3), 229-239, Jul. 2017, Refereed, Not invited - Successful Treatment for Chronic Hepatitis C-Autoimmune Hepatitis Overlap Syndrome due to Daclatasvir and Asunaprevir
Sugiura A; Wada S; Mori H; Kimura T; Matsuda Y; Tanaka N; Tanaka E; Kiyosawa K
Case Rep Gastroenterol, 11(2), 305-311, May 2017, Refereed, Not invited
Corresponding - Role of the lipid-regulated NF-kappa B/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury
Zhong-Ze Fang; Naoki Tanaka; Dan Lu; Chang-Tao Jiang; Wei-Hua Zhang; Chunze Zhang; Zuo Du; Zhi-Wei Fu; Peng Gao; Yun-Feng Cao; Hong-Zhi Sun; Zhi-Tu Zhu; Yan Cai; Kristopher W. Krausz; Zhi Yao; Frank J. Gonzalez
ARCHIVES OF TOXICOLOGY, 91(5), 2235-2244, May 2017, Refereed, Not invited - Clinicopathological characteristics of non-B non-C hepatocellular carcinoma without past hepatitis B virus infection
Takefumi Kimura; Akira Kobayashi; Naoki Tanaka; Kenji Sano; Michiharu Komatsu; Naoyuki Fujimori; Tomoo Yamazaki; Soichiro Shibata; Yuki Ichikawa; Satoru Joshita; Takeji Umemura; Akihiro Matsumoto; Akira Horiuchi; Hiromitsu Mori; Shuichi Wada; Kendo Kiyosawa; Shin-ichi Miyagawa; Eiji Tanaka
HEPATOLOGY RESEARCH, 47(5), 405-418, Apr. 2017, Refereed, Not invited
Corresponding - Development of diffuse large B-cell lymphoma from follicular lymphoma of the duodenum: changes in endoscopic findings during a 6-year follow-up.
Hiroyuki Kitabatake; Tadanobu Nagaya; Naoki Tanaka; Hiroyoshi Ota; Kenji Sano; Naoko Asano; Tomoaki Suga; Yoshiyuki Nakamura; Taiji Akamatsu; Eiji Tanaka
Clinical journal of gastroenterology, 10(1), 79-85, Feb. 2017, Refereed - Massive ascites caused by intra-pancreatic arterioportal fistula: a rare complication of chronic pancreatitis.
Tomoo Yamazaki; Yasuhide Ochi; Naoki Tanaka; Takayuki Watanabe; Yugo Iwaya; Ayako Seki; Etsuo Hara; Eiji Tanaka; Tomoharu Watanabe; Shun Imai; Osamu Hasebe
Clinical journal of gastroenterology, 10(1), 73-78, Feb. 2017, Refereed
Corresponding - Association between endotoxemia and histological features of nonalcoholic fatty liver disease
Hiroyuki Kitabatake; Naoki Tanaka; Naoyuki Fujimori; Michiharu Komatsu; Ayaka Okubo; Kyogo Kakegawa; Takefumi Kimura; Ayumi Sugiura; Tomoo Yamazaki; Soichiro Shibata; Yuki Ichikawa; Satoru Joshita; Takeji Umemura; Akihiro Matsumoto; Masayoshi Koinuma; Kenji Sano; Toshifumi Aoyama; Eiji Tanaka
WORLD JOURNAL OF GASTROENTEROLOGY, 23(4), 712-722, Jan. 2017, Refereed, Not invited
Corresponding - Vonoprazan-Based Regimen Is More Useful than PPI-Based One as a First-Line Helicobacter pylori Eradication: A Randomized Controlled Trial
Masafumi Maruyama; Naoki Tanaka; Daisuke Kubota; Masayuki Miyajima; Takefumi Kimura; Koujiro Tokutake; Ryujiro Imai; Toru Fujisawa; Hiromitsu Mori; Yoshiaki Matsuda; Shuichi Wada; Akira Horiuchi; Kendo Kiyosawa
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, -, 2017, Refereed, Not invited - PPAR alpha-dependent cholesterol/testosterone disruption in Leydig cells mediates 2,4-dichlorophenoxyacetic acid-induced testicular toxicity in mice
Yukiko Harada; Naoki Tanaka; Motoki Ichikawa; Yuji Kamijo; Eiko Sugiyama; Frank J. Gonzalez; Toshifumi Aoyama
ARCHIVES OF TOXICOLOGY, 90(12), 3061-3071, Dec. 2016, Refereed, Not invited
Lead, Corresponding - Age-dependent PPAR alpha activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene
Yangyang Tian; Yang Yang; Xiaowei Zhang; Takero Nakajima; Naoki Tanaka; Eiko Sugiyama; Yuji Kamijo; Yu Lu; Kyoji Moriya; Kazuhiko Koike; Frank J. Gonzalez; Toshifumi Aoyama
GLYCOCONJUGATE JOURNAL, 33(6), 927-936, Dec. 2016, Refereed, Not invited - Activation of PPAR alpha by Fatty Acid Accumulation Enhances Fatty Acid Degradation and Sulfatide Synthesis
Yang Yang; Yuyao Feng; Xiaowei Zhang; Takero Nakajima; Naoki Tanaka; Eiko Sugiyama; Yuji Kamijo; Toshifumi Aoyama
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 240(2), 113-122, Oct. 2016, Refereed, Not invited - Controlled attenuation parameter is correlated with actual hepatic fat content in patients with non-alcoholic fatty liver disease with none-to-mild obesity and liver fibrosis
Naoyuki Fujimori; Naoki Tanaka; Soichiro Shibata; Kenji Sano; Tomoo Yamazaki; Tomohiro Sekiguchi; Hiroyuki Kitabatake; Yuki Ichikawa; Takefumi Kimura; Michiharu Komatsu; Takeji Umemura; Akihiro Matsumoto; Eiji Tanaka
HEPATOLOGY RESEARCH, 46(10), 1019-1027, Sep. 2016, Refereed, Not invited
Corresponding - Determination of the cut-off score of an endoscopic scoring method to predict whether elderly patients with dysphagia can eat pureed diets.
Torao Sakamoto; Akira Horiuchi; Toshiyuki Makino; Masashi Kajiyama; Naoki Tanaka; Masamitsu Hyodo
World journal of gastrointestinal endoscopy, 8(6), 288-94, Mar. 2016, Refereed - Irinotecan (CPT-11)-induced elevation of bile acids potentiates suppression of IL-10 expression
Zhong-Ze Fang; Dunfang Zhang; Yun-Feng Cao; Cen Xie; Dan Lu; Dong-Xue Sun; Naoki Tanaka; Changtao Jiang; Qianming Chen; Yu Chen; Haina Wang; Frank J. Gonzalez
TOXICOLOGY AND APPLIED PHARMACOLOGY, 291, 21-27, Jan. 2016, Refereed, Not invited - Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans
Ming-Jiang Xu; Yan Cai; Hua Wang; Jose Altamirano; Binxia Chang; Adeline Bertola; Gemma Odena; Jim Lu; Naoki Tanaka; Kimihiko Matsusue; Tsutomu Matsubara; Partha Mukhopadhyay; Shioko Kimura; Pal Pacher; Frank J. Gonzalez; Ramon Bataller; Bin Gao
GASTROENTEROLOGY, 149(4), 1030-U367, Oct. 2015, Refereed, Not invited - St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling
Soumen K. Manna; Srujana Golla; Jaya Prakash Golla; Naoki Tanaka; Yan Cai; Shogo Takahashi; Kristopher W. Krausz; Tsutomu Matsubara; Ilia Korboukh; Frank J. Gonzalez
CANCER PREVENTION RESEARCH, 8(9), 786-795, Sep. 2015, Refereed, Not invited - Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation
Limin Zhang; Robert G. Nichols; Jared Correll; Iain A. Murray; Naoki Tanaka; Philip B. Smith; Troy D. Hubbard; Aswathy Sebastian; Istvan Albert; Emmanuel Hatzakis; Frank J. Gonzalez; Gary H. Perdew; Andrew D. Patterson
ENVIRONMENTAL HEALTH PERSPECTIVES, 123(7), 679-688, Jul. 2015, Refereed, Not invited - Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet
Naoki Tanaka; Shogo Takahashi; Yuan Zhang; Kristopher W. Krausz; Philip B. Smith; Andrew D. Patterson; Frank J. Gonzalez
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1852(7), 1242-1252, Jul. 2015, Refereed, Not invited
Lead - Mechanism of the development of nonalcoholic steatohepatitis after pancreaticoduodenectomy.
Nagaya T; Tanaka N; Kimura T; Kitabatake H; Fujimori N; Komatsu M; Horiuchi A; Yamaura T; Umemura T; Sano K; Gonzalez FJ; Aoyama T; Tanaka E
BBA Clin, 3, 168-74-74, Feb. 2015, Refereed, Not invited
Corresponding - Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease.
Changtao Jiang; Cen Xie; Fei Li; Limin Zhang; Robert G Nichols; Kristopher W Krausz; Jingwei Cai; Yunpeng Qi; Zhong-Ze Fang; Shogo Takahashi; Naoki Tanaka; Dhimant Desai; Shantu G Amin; Istvan Albert; Andrew D Patterson; Frank J Gonzalez
The Journal of clinical investigation, 125(1), 386-402, Jan. 2015, Refereed - Adipocyte-specific Disruption of Fat-specific Protein 27 Causes Hepatosteatosis and Insulin Resistance in High-fat Diet-fed Mice
Naoki Tanaka; Shogo Takahashi; Tsutomu Matsubara; Changtao Jiang; Wataru Sakamoto; Tatyana Chanturiya; Ruifeng Teng; Oksana Gavrilova; Frank J. Gonzalez
JOURNAL OF BIOLOGICAL CHEMISTRY, 290(5), 3092-3105, Jan. 2015, Refereed, Not invited
Lead - Helicobacter pylori-negative Differentiated Adenocarcinoma of the Stomach
Tadanobu Nagaya; Naoki Tanaka; Yugo Iwaya; Yoko Jimbo; Toshiharu Tatai; Tetsuya Ito; Ayako Seki; Kenichi Suzawa; Yasuhide Ochi; Etsuo Hara; Manabu Takata; Toshiaki Otsuki; Mai Iwaya; Noriko Hosaka; Norikazu Arakura; Eiji Tanaka; Osamu Hasebe
INTERNAL MEDICINE, 54(22), 2857-2862, 2015, Refereed, Not invited - Activation of Intestinal Human Pregnane X Receptor Protects against Azoxymethane/Dextran Sulfate Sodium-Induced Colon Cancer
Jie Cheng; Zhong-Ze Fang; Kenjiro Nagaoka; Minoru Okamoto; Aijuan Qu; Naoki Tanaka; Shioko Kimura; Frank J. Gonzalez
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 351(3), 559-567, Dec. 2014, Refereed, Not invited - Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-kappa B and STAT3 signaling
Aiming Liu; Naoki Tanaka; Lu Sun; Bin Guo; Jung-Hwan Kim; Kristopher W. Krausz; Zhongze Fang; Changtao Jiang; Julin Yang; Frank J. Gonzalez
CHEMICO-BIOLOGICAL INTERACTIONS, 223, 80-86, Nov. 2014, Refereed, Not invited
Lead - Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet
Naoki Tanaka; Shogo Takahashi; Zhong-Ze Fang; Tsutomu Matsubara; Kristopher W. Krausz; Aijuan Qu; Frank J. Gonzalez
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1841(11), 1596-1607, Nov. 2014, Refereed, Not invited
Lead - PPAR alpha-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate
Yunpeng Qi; Changtao Jiang; Naoki Tanaka; Kristopher W. Krausz; Chad N. Brocker; Zhong-Ze Fang; Bryce X. Bredell; Yatrik M. Shah; Frank J. Gonzalez
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 307(5), G564-G573, Sep. 2014, Refereed, Not invited - Laparoscopic findings of congenital hepatic fibrosis: A case report and review of the published work
Michiharu Komatsu; Naoki Tanaka; So-Ichirou Shibata; Takefumi Kimura; Yuki Ichikawa; Susumu Morita; Satoru Joshita; Tadanobu Nagaya; Takeji Umemura; Tetsuya Ichijo; Akihiro Matsumoto; Kaname Yoshizawa; Eiji Tanaka
HEPATOLOGY RESEARCH, 44(7), 818-824, Jul. 2014, Refereed, Not invited
Corresponding - Herb-drug interaction prediction based on the high specific inhibition of andrographolide derivatives towards UDP-glucuronosyltransferase (UGT) 2B7
Hai-Ying Ma; Dong-Xue Sun; Yun-Feng Cao; Chun-Zhi Ai; Yan-Qing Qu; Cui-Min Hu; Changtao Jiang; Pei-Pei Dong; Xiao-Yu Sun; Mo Hong; Naoki Tanaka; Frank J. Gonzalez; Xiao-Chi Ma; Zhong-Ze Fang
TOXICOLOGY AND APPLIED PHARMACOLOGY, 277(1), 86-94, May 2014, Refereed, Not invited - Biomarkers of Coordinate Metabolic Reprogramming in Colorectal Tumors in Mice and Humans
Soumen K. Manna; Naoki Tanaka; Kristopher W. Krausz; Majda Haznadar; Xiang Xue; Tsutomu Matsubara; Elise D. Bowman; Eric R. Fearon; Curtis C. Harris; Yatrik M. Shah; Frank J. Gonzalez
GASTROENTEROLOGY, 146(5), 1313-1324, May 2014, Refereed, Not invited - In vivo effects of the pure aryl hydrocarbon receptor antagonist GNF-351 after oral administration are limited to the gastrointestinal tract
Zhong-Ze Fang; Kristopher W. Krausz; Kenjiro Nagaoka; Naoki Tanaka; Krishne Gowda; Shantu G. Amin; Gary H. Perdew; Frank J. Gonzalez
BRITISH JOURNAL OF PHARMACOLOGY, 171(7), 1735-1746, Apr. 2014, Refereed, Not invited - Removal of small colorectal polyps in anticoagulated patients: a prospective randomized comparison of cold snare and conventional polypectomy
Akira Horiuchi; Yoshiko Nakayama; Masashi Kajiyama; Naoki Tanaka; Kenji Sano; David Y. Graham
GASTROINTESTINAL ENDOSCOPY, 79(3), 417-423, Mar. 2014, Refereed, Not invited - Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice
Jie Cheng; Zhong-Ze Fang; Jung-Hwan Kim; Kristopher W. Krausz; Naoki Tanaka; John Y. L. Chiang; Frank J. Gonzalez
JOURNAL OF LIPID RESEARCH, 55(3), 455-465, Mar. 2014, Refereed, Not invited - Chronic ethanol consumption decreases serum sulfatide levels by suppressing hepatic cerebroside sulfotransferase expression in mice
Hiroki Kanbe; Yuji Kamijo; Takero Nakajima; Naoki Tanaka; Eiko Sugiyama; Lixuan Wang; Zhong-Ze Fang; Atsushi Hara; Frank J. Gonzalez; Toshifumi Aoyama
ARCHIVES OF TOXICOLOGY, 88(2), 367-379, Feb. 2014, Not invited
Corresponding - A model of in vitro UDP-glucuronosyltransferase inhibition by bile acids predicts possible metabolic disorders
Zhong-Ze Fang; Rong-Rong He; Yun-Feng Cao; Naoki Tanaka; Changtao Jiang; Kristopher W. Krausz; Yunpeng Qi; Pei-Pei Dong; Chun-Zhi Ai; Xiao-Yu Sun; Mo Hong; Guang-Bo Ge; Frank J. Gonzalez; Xiao-Chi Ma; Hong-Zhi Sun
JOURNAL OF LIPID RESEARCH, 54(12), 3334-3344, Dec. 2013, Refereed, Not invited - Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum
Zhong-Ze Fang; Kristopher W. Krausz; Naoki Tanaka; Fei Li; Aijuan Qu; Jeffrey R. Idle; Frank J. Gonzalez
ARCHIVES OF TOXICOLOGY, 87(11), 1975-1987, Nov. 2013, Refereed, Not invited - Peroxisome proliferator-activated receptor α mediates enhancement of gene expression of cerebroside sulfotransferase in several murine organs
Takero Nakajima; Yuji Kamijo; Huang Yuzhe; Takefumi Kimura; Naoki Tanaka; Eiko Sugiyama; Kozo Nakamura; Mamoru Kyogashima; Atsushi Hara; Toshifumi Aoyama
Glycoconjugate Journal, 30(6), 553-560, Aug. 2013, Refereed, Not invited - Safety and Effectiveness of Low-Dose Propofol Sedation During and After Esophagogastroduodenoscopy in Child A and B Cirrhotic Patients
Naoki Tanaka; Akira Horiuchi; Yoshiko Nakayama; Yoshihiko Katsuyama; Masatsugu Isobe; Toshifumi Aoyama; Eiji Tanaka; Shigeru Ohmori
DIGESTIVE DISEASES AND SCIENCES, 58(5), 1383-1389, May 2013, Refereed, Not invited
Lead - TGF-beta-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury
Tsutomu Matsubara; Naoki Tanaka; Misako Sato; Dong Wook Kang; Kristopher W. Krausz; Kathleen C. Flanders; Kazuo Ikeda; Hans Luecke; Lalage M. Wakefield; Frank J. Gonzalez
JOURNAL OF LIPID RESEARCH, 53(12), 2698-2707, Dec. 2012, Refereed, Not invited - Metabolomics Identifies an Inflammatory Cascade Involved in Dioxin- and Diet-Induced Steatohepatitis
Tsutomu Matsubara; Naoki Tanaka; Kristopher W. Krausz; Soumen K. Manna; Dong Wook Kang; Erik R. Anderson; Hans Luecke; Andrew D. Patterson; Yatrik M. Shah; Frank J. Gonzalez
CELL METABOLISM, 16(5), 634-644, Nov. 2012, Refereed, Not invited
Lead - Long-term outcome of Japanese patients with type 1 autoimmune hepatitis.
Kaname Yoshizawa; Akihiro Matsumoto; Tetsuya Ichijo; Takeji Umemura; Satoru Joshita; Michiharu Komatsu; Naoki Tanaka; Eiji Tanaka; Masao Ota; Yoshihiko Katsuyama; Kendo Kiyosawa; Masanori Abe; Morikazu Onji
Hepatology (Baltimore, Md.), 56(2), 668-76, Aug. 2012, Refereed - The modulation of hepatic adenosine triphosphate and inflammation by eicosapentaenoic acid during severe fibrotic progression in the SHRSP5/Dmcr rat model.
Xiaofang Jia; Hisao Naito; Husna Yetti; Hazuki Tamada; Kazuya Kitamori; Yumi Hayashi; Nozomi Yamagishi; Dong Wang; Yukie Yanagiba; Yuki Ito; Juncai Wang; Naoki Tanaka; Katsumi Ikeda; Yukio Yamori; Tamie Nakajima
Life sciences, 90(23-24), 934-43, Jun. 2012, Refereed - Clinical Characteristics of Young-Onset Ischemic Colitis
Takefumi Kimura; Akihiro Shinji; Akira Horiuchi; Naoki Tanaka; Tadanobu Nagaya; Takashi Shigeno; Naoshi Nakamura; Michiharu Komatsu; Takeji Umemura; Norikazu Arakura; Akihiro Matsumoto; Eiji Tanaka
DIGESTIVE DISEASES AND SCIENCES, 57(6), 1652-1659, Jun. 2012, Refereed, Not invited
Corresponding - Attenuation of kidney injuries maintains serum sulfatide levels dependent on hepatic synthetic ability: a possible involvement of oxidative stress.
Xiaona Sheng; Takero Nakajima; Lixuan Wang; Xiaowei Zhang; Yuji Kamijo; Kyoko Takahashi; Naoki Tanaka; Eiko Sugiyama; Mamoru Kyogashima; Toshifumi Aoyama; Atsushi Hara
The Tohoku journal of experimental medicine, 227(1), 1-12, May 2012, Refereed, Not invited - Modulation of ammonium perfluorooctanoate-induced hepatic damage by genetically different PPARα in mice.
Tomohiko Nakagawa; Doni Hikmat Ramdhan; Naoki Tanaka; Hisao Naito; Hazuki Tamada; Yuki Ito; Yufei Li; Yumi Hayashi; Nozomi Yamagishi; Yukie Yanagiba; Toshifumi Aoyama; Frank J Gonzalez; Tamie Nakajima
Archives of toxicology, 86(1), 63-74, Jan. 2012, Refereed - Clinical characteristics of de novo nonalcoholic fatty liver disease following pancreaticoduodenectomy
Naoki Tanaka; Akira Horiuchi; Takahide Yokoyama; Gengo Kaneko; Naoto Horigome; Takahiro Yamaura; Tadanobu Nagaya; Michiharu Komatsu; Kenji Sano; Shin-ichi Miyagawa; Toshifumi Aoyama; Eiji Tanaka
JOURNAL OF GASTROENTEROLOGY, 46(6), 758-768, Jun. 2011, Refereed, Not invited
Lead, Corresponding - Accurate and simple method for quantification of hepatic fat content using magnetic resonance imaging: a prospective study in biopsy-proven nonalcoholic fatty liver disease
Tomoko Hatta; Yasunari Fujinaga; Masumi Kadoya; Hitoshi Ueda; Hiroaki Murayama; Masahiro Kurozumi; Kazuhiko Ueda; Michiharu Komatsu; Tadanobu Nagaya; Satoru Joshita; Ryo Kodama; Eiji Tanaka; Tsuyoshi Uehara; Kenji Sano; Naoki Tanaka
JOURNAL OF GASTROENTEROLOGY, 45(12), 1263-1271, Dec. 2010, Refereed, Not invited
Last - Differential response to trichloroethylene-induced hepatosteatosis in wild-type and PPARalpha-humanized mice.
Doni Hikmat Ramdhan; Michihiro Kamijima; Dong Wang; Yuki Ito; Hisao Naito; Yukie Yanagiba; Yumi Hayashi; Naoki Tanaka; Toshifumi Aoyama; Frank J Gonzalez; Tamie Nakajima
Environmental health perspectives, 118(11), 1557-63, Nov. 2010, Refereed - Eicosapentaenoic acid improves hepatic steatosis independent of PPAR alpha activation through inhibition of SREBP-1 maturation in mice
Naoki Tanaka; Xiuguo Zhang; Eiko Sugiyama; Hiroyuki Kono; Akira Horiuchi; Takero Nakajima; Hiroki Kanbe; Eiji Tanaka; Frank J. Gonzalez; Toshifumi Aoyama
BIOCHEMICAL PHARMACOLOGY, 80(10), 1601-1612, Nov. 2010, Refereed, Not invited
Lead - Association between serum uric acid levels and cardiometabolic risk factors among Japanese junior high school students.
Minoru Hongo; Hiroya Hidaka; Shigeko Sakaguchi; Keisuke Nakanishi; Motoki Ichikawa; Naoko Hirota; Naoki Tanaka; Goro Tsuruta; Yoshikazu Yazaki; Osamu Kinoshita; Uichi Ikeda; Kenichi Koike
Circulation journal : official journal of the Japanese Circulation Society, 74(8), 1570-7, Aug. 2010, Refereed - Serum Fragmented Cytokeratin 18 Levels Reflect the Histologic Activity Score of Nonalcoholic Fatty Liver Disease More Accurately Than Serum Alanine Aminotransferase Levels
Masaru Tsutsui; Naoki Tanaka; Masatomo Kawakubo; Yo Sheena; Akira Horiuchi; Michiharu Komatsu; Tadanobu Nagaya; Satoru Joshita; Takeji Umemura; Tetsuya Ichijo; Akihiro Matsumoto; Kaname Yoshizawa; Toshifumi Aoyama; Eiji Tanaka; Kenji Sano
JOURNAL OF CLINICAL GASTROENTEROLOGY, 44(6), 440-447, Jul. 2010, Refereed, Not invited
Lead, Corresponding - Nonalcoholic fatty liver disease in Japanese junior high school students: its prevalence and relationship to lifestyle habits
Goro Tsuruta; Naoki Tanaka; Minoru Hongo; Michiharu Komatsu; Akira Horiuchi; Kaeko Hamamoto; Chieko Iguchi; Yoshiko Nakayama; Takeji Umemura; Tetsuya Ichijo; Akihiro Matsumoto; Kaname Yoshizawa; Toshifumi Aoyama; Eiji Tanaka
JOURNAL OF GASTROENTEROLOGY, 45(6), 666-672, Jun. 2010, Refereed, Not invited
Lead, Corresponding - Hood-assisted colonoscopy is more effective in detection of colorectal adenomas than narrow-band imaging.
Akira Horiuchi; Yoshiko Nakayama; Naoyuki Kato; Yasuyuki Ichise; Masashi Kajiyama; Naoki Tanaka
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 8(4), 379-83, Apr. 2010, Refereed
Last - Multiple roles of PPARalpha in brown adipose tissue under constitutive and cold conditions.
Makiko Komatsu; Yuhong Tong; Yufeng Li; Takero Nakajima; Gang Li; Rui Hu; Eiko Sugiyama; Yuji Kamijo; Naoki Tanaka; Atsushi Hara; Toshifumi Aoyama
Genes to cells : devoted to molecular & cellular mechanisms, 15(2), 91-100, Feb. 2010, Refereed - Effect of bezafibrate on hepatic oxidative stress: comparison between conventional experimental doses and clinically-relevant doses in mice.
Takero Nakajima; Naoki Tanaka; Gang Li; Rui Hu; Yuji Kamijo; Atsushi Hara; Toshifumi Aoyama
Redox report : communications in free radical research, 15(3), 123-30, 2010, Refereed
Corresponding - Conventional Diet Therapy for Hyperammonemia is Risky in the Treatment of Hepatic Encephalopathy Associated with Citrin Deficiency
Fukushima, Kazuhiro; Yazaki, Masahide; Nakamura, Mio; Tanaka, Naoki; Kobayashi, Keiko; Saheki, Takeyori; Takei, Hideki; Ikeda, Shu-ichi
INTERNAL MEDICINE, 49(3), 243-247, 2010, Refereed, Not invited - 一般中学生の高尿酸血症と生活習慣病との関連
本郷 実; 日高 宏哉; 阪口 しげ子; 市川 元基; 池田 宇一; 田中 直樹; 鶴田 悟郎; 小池 健一
痛風と核酸代謝 = Gout and nucleic acid metabolism, 33(1), 17-26, Jul. 2009, Refereed, Not invited - Efficacy and safety of addition of minor bloodletting (petit phlebotomy) in hepatitis C virus-infected patients receiving regular glycyrrhizin injections
Naoki Tanaka; Akira Horiuchi; Takahiro Yamaura; Michiharu Komatsu; Takahide Yokoyama; Shinji Okaniwa; Tadanobu Nagaya; Kaname Yoshizawa; Kendo Kiyosawa; Toshifumi Aoyama; Eiji Tanaka
JOURNAL OF GASTROENTEROLOGY, 44(6), 577-582, Jun. 2009, Refereed, Not invited
Lead, Corresponding - Polyenephosphatidylcholine prevents alcoholic liver disease in PPAR alpha-null mice through attenuation of increases in oxidative stress
Wataru Okiyama; Naoki Tanaka; Tamie Nakajima; Eiji Tanaka; Kendo Kiyosawa; Frank J. Gonzalez; Toshifumi Aoyama
JOURNAL OF HEPATOLOGY, 50(6), 1236-1246, Jun. 2009, Refereed, Not invited
Lead, Corresponding - Bezafibrate at Clinically Relevant Doses Decreases Serum/Liver Triglycerides via Down-Regulation of Sterol Regulatory Element-Binding Protein-1c in Mice: A Novel Peroxisome Proliferator-Activated Receptor alpha-Independent Mechanism
Takero Nakajima; Naoki Tanaka; Hiroki Kanbe; Atsushi Hara; Yuji Kamijo; Xiaowei Zhang; Frank J. Gonzalez; Toshifumi Aoyama
MOLECULAR PHARMACOLOGY, 75(4), 782-792, Apr. 2009, Refereed, Not invited
Corresponding - Prospective comparison between sedated high-definition oral and unsedated ultrathin transnasal esophagogastroduodenoscopy in the same subjects: pilot study.
Akira Horiuchi; Yoshiko Nakayama; Nao Hidaka; Yasuyuki Ichise; Masashi Kajiyama; Naoki Tanaka
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 21(1), 24-8, Jan. 2009, Refereed
Last - Primitive Neuroectodermal Tumor as a Differential Diagnosis of CD56-Positive Tumors in Adults
Nagaya, Tadanobu; Tanaka, Naoki; Kamijo, Atsushi; Joshita, Satoru; Nakazawa, Koh; Miyabayashi, Hideharu; Yoneda, Suguru; Ito, Tetsuya; Komatsu, Michiharu; Tanaka, Eiji; Kitano, Kiyoshi
INTERNAL MEDICINE, 48(15), 1267-1272, 2009, Refereed, Not invited
Corresponding - Pretreatment prediction of virological response to peginterferon plus ribavirin therapy in chronic hepatitis C patients using viral and host factors.
Haruaki Shirakawa; Akihiro Matsumoto; Satoru Joshita; Michiharu Komatsu; Naoki Tanaka; Takeji Umemura; Tetsuya Ichijo; Kaname Yoshizawa; Kendo Kiyosawa; Eiji Tanaka
Hepatology (Baltimore, Md.), 48(6), 1753-60, Dec. 2008, Refereed - Citrin deficiency as a cause of chronic liver disorder mimicking non-alcoholic fatty liver disease
Michiharu Komatsu; Masahide Yazaki; Naoki Tanaka; Kenji Sano; Etsuko Hashimoto; Yo-ichi Taker; Yuan-Zong Song; Eiji Tanaka; Kendo Kiyosawa; Takeyori Saheki; Toshifumi Aoyama; Keiko Kobayashi
JOURNAL OF HEPATOLOGY, 49(5), 810-820, Nov. 2008, Refereed, Not invited
Corresponding - Development from simple steatosis to liver cirrhosis and hepatocellular carcinoma: a 27-year follow-up case.
Tadanobu Nagaya; Naoki Tanaka; Michiharu Komatsu; Tetsuya Ichijo; Kenji Sano; Akira Horiuchi; Satoru Joshita; Takeji Umemura; Akihiro Matsumoto; Kaname Yoshizawa; Toshifumi Aoyama; Kendo Kiyosawa; Eiji Tanaka
Clinical journal of gastroenterology, 1(3), 116-121, Oct. 2008, Refereed
Corresponding - Transgastric Diversion of Transnasal Long Tube Placement Using a Percutaneous Endoscopic Gastrostomy Site in a Patient with Bowel Obstruction and Massive Ascites due to Ovarian Carcinoma.
Akira Horiuchi; Yoshiko Nakayama; Naoki Tanaka
Case reports in gastroenterology, 2(3), 326-9, Sep. 2008, Refereed
Last - Insulin resistance and hepatitis C virus: a case-control study of non-obese, non-alcoholic and non-steatotic hepatitis virus carriers with persistently normal serum aminotransferase
Naoki Tanaka; Tadanobu Nagaya; Michiharu Komatsu; Akira Horiuchi; Goro Tsuruta; Haruaki Shirakawa; Takeji Umemura; Tetsuya Ichijo; Akihiro Matsumoto; Kaname Yoshizawa; Toshifumi Aoyama; Kendo Kiyosawa; Eiji Tanaka
LIVER INTERNATIONAL, 28(8), 1104-1111, Sep. 2008, Refereed, Not invited
Lead, Corresponding - Eicosapentaenoic acid lowers plasma and liver cholesterol levels in the presence of peroxisome proliferators-activated receptor alpha.
Eiko Sugiyama; Yasuko Ishikawa; Yufeng Li; Tomoko Kagai; Misaki Nobayashi; Naoki Tanaka; Yuji Kamijo; Shin Yokoyama; Atsushi Hara; Toshifumi Aoyama
Life sciences, 83(1-2), 19-28, Jul. 2008, Refereed - Cholesterol-lowering effect of bezafibrate is independent of peroxisome proliferator-activated receptor activation in mice
Takero Nakajima; Naoki Tanaka; Eiko Sugiyama; Yuji Kamijo; Atsushi Hara; Rui Hu; Gang Li; Yufeng Li; Kozo Nakamura; Frank J. Gonzalez; Toshifumi Aoyama
BIOCHEMICAL PHARMACOLOGY, 76(1), 108-119, Jul. 2008, Refereed, Not invited
Corresponding - PPAR alpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice
Naoki Tanaka; Kyoji Moriya; Kendo Kiyosawa; Kazuhiko Koike; Frank J. Gonzalez; Toshifurni Aoyama
JOURNAL OF CLINICAL INVESTIGATION, 118(2), 683-694, Feb. 2008, Refereed, Not invited
Lead, Corresponding - Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: Implications for HCV-associated hepatocarcinogenesis
Naoki Tanaka; Kyoji Moriya; Kendo Kiyosawa; Kazuhiko Koike; Toshifumi Aoyama
INTERNATIONAL JOURNAL OF CANCER, 122(1), 124-131, Jan. 2008, Refereed, Not invited
Lead, Corresponding - Differential effects of aging, drinking and exercise on serum cholesterol levels dependent on the PPARA-V227A polymorphism.
Hisao Naito; Michihiro Kamijima; Osamu Yamanoshita; Ai Nakahara; Takahiko Katoh; Naoki Tanaka; Toshifumi Aoyama; Frank J Gonzalez; Tamie Nakajima
Journal of occupational health, 49(5), 353-62, Sep. 2007, Refereed - Effect of precut sphincterotomy on biliary cannulation based on the characteristics of the major duodenal papilla.
Akira Horiuchi; Yoshiko Nakayama; Masashi Kajiyama; Naoki Tanaka
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 5(9), 1113-8, Sep. 2007, Refereed
Last - Efficacy and safety of 6-month iron reduction therapy in patients with hepatitis C virus-related cirrhosis: a pilot study
Naoki Tanaka; Akira Horiuchi; Takahiro Yamaura; Michiharu Komatsu; Eiji Tanaka; Kendo Kiyosawa
JOURNAL OF GASTROENTEROLOGY, 42(1), 49-55, Jan. 2007, Refereed, Not invited
Lead, Corresponding - Useful parameters for distinguishing nonalcoholic steatohepatitis with mild steatosis from cryptogenic chronic hepatitis in the Japanese population
Naoki Tanaka; Eiji Tanaka; Yo Sheena; Michiharu Komatsu; Wataru Okiyama; Noriko Misawa; Hidetomo Muto; Takeji Umemura; Tetsuya Ichijo; Akihiro Matsumoto; Kaname Yoshizawa; Akira Horiuchi; Kendo Kiyosawa
LIVER INTERNATIONAL, 26(8), 956-963, Oct. 2006, Refereed, Not invited
Lead, Corresponding - Haploinsufficiency in the PPARα and LDL receptor genes leads to gender- and age-specific obesity and hyperinsulinemia.
SUGIYAMA Eiko; SUGIYAMA Eiko; TANAKA Naoki; NAKAJIMA Tamie; KAMIJO Yuji; YOKOYAMA Shin; LI Yufeng; GONZALEZ Frank J; AOYAMA Toshifumi
Biochem Bioph Res Co, 350(2), 370-376, 2006, Refereed, Not invited - Acute colorectal obstruction treated by means of transanal drainage tube: effectiveness before surgery and stenting.
Akira Horiuchi; Yoshiko Nakayama; Naoki Tanaka; Masashi Kajiyama; Hideyasu Fujii; Takahide Yokoyama; Ken Hayashi
The American journal of gastroenterology, 100(12), 2765-70, Dec. 2005, Refereed - A case of nephrotic syndrome due to lupus nephritis which was controlled with low-density lipoprotein apheresis.
Yuji Kamijo; Yoko Kaneko; Toru Ichikawa; Nobuhiko Kobayashi; Takayuki Koyama; Tetsuji Kakegawa; Hiroshi Kamijo; Keiichi Kono; Satoshi Minami; Naoki Tanaka; Hideo Arakura; Masayuki Hirata; Makoto Higuchi; Kendo Kiyosawa; Kazuhiko Hora
Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis, 6(6), 459-62, Dec. 2002, Refereed - Age-dependent obesity and hyperinsulinemia in PPARα(+/–) LDLR(+/–) male mice.
Sugiyama E; Tanaka N; Nakajima T; Kamijo Y; Aoyama T
J Diabetes Complicat, 16, 51-56, 2001, Not invited - 脂肪肝とPPARα
Aoyama T; Nakajima T; Tanaka N
肝臓病学の進歩, 27(9), 1-7, 2001, Refereed, Not invited
MISC
- 【PPARα revisit】 PPARαと疾患 NASHとPPARα
田中 直樹; 木村 岳史; 長屋 匡信; 小松 通治; 青山 俊文
The Lipid, 27(4), 336 - 342, Oct. 2016, Not invited - Toll-like receptor 4とMyD 88がNAFLDの線維化に関連する
小松 通治; 田中 直樹; 長屋 匡信; 市川 雪; 木村 岳史; 森田 進; 城下 智; 梅村 武司; 松本 晶博; 田中 榮司
肝臓, 53(Suppl.1), A482 - A482, Apr. 2012, Not invited - 【NASH/NAFLDのUp to Date】 NASH/NAFLDの分子病態メカニズム Burned-out NASHの形成機構 肝細胞内の脂肪代謝関連遺伝子解析について
小松 通治; 長屋 匡信; 田中 直樹; 田中 榮司
肝・胆・膵, 60(6), 941 - 946, Jun. 2010, Not invited - 中学生における非アルコール性脂肪肝疾患(NAFLD)の頻度と生活習慣の検討
小松 通治; 田中 直樹; 長屋 匡信; 田中 榮司
肝臓, 51(Suppl.1), A388 - A388, Apr. 2010, Not invited - 膵・胆道疾患における消化吸収障害とその対策 膵頭十二指腸切除術後のNAFLD・その臨床像と発症機構
長屋 匡信; 田中 直樹; 田中 榮司
日本消化器病学会雑誌, 106(臨増大会), A723 - A723, Sep. 2009, Not invited - C型慢性肝炎1b型高ウイルス量患者に対するペグインターフェロンとリバビリン併用療法の治療効果に与える宿主およびウイルス因子の影響
松本 晶博; 白川 晴章; 米沢 傑; 上條 敦; 長屋 匡信; 城下 智; 小松 通治; 田中 直樹; 梅村 武司; 一條 哲也; 吉澤 要; 太田 正穂; 勝山 善彦; 清澤 研道; 田中 榮司
肝臓, 50(Suppl.1), A131 - A131, Apr. 2009, Not invited - 原発性胆汁性肝硬変患者におけるゲノムワイドマイクロサテライト解析の検討
城下 智; 梅村 武司; 吉澤 要; 一條 哲也; 米田 傑; 上條 敦; 長屋 匡信; 小松 通治; 田中 直樹; 松本 晶博; 田中 榮司
肝臓, 50(Suppl.1), A162 - A162, Apr. 2009, Not invited - NASHでは線維化進行に伴いなぜ肝脂肪沈着が減少するのか 肝生検組織を用いた脂質代謝関連分子の発現解析
長屋 匡信; 田中 直樹; 上條 敦; 城下 智; 小松 通治; 梅村 武司; 一條 哲也; 松本 晶博; 吉澤 要; 田中 榮司
肝臓, 50(Suppl.1), A211 - A211, Apr. 2009, Not invited - 血中サイトケラチン18値はNAFLD histological activity scoreを反映する有用なバイオマーカーである
田中 直樹; 小松 通治; 長屋 匡信; 田中 榮司
肝臓, 50(Suppl.1), A324 - A324, Apr. 2009, Not invited - C型慢性肝炎に対するペグインターフェロンα-2a+リバビリン併用療法の有効性・安全性に関する再治療例を含めた検討
松本 晶博; 宜保 行雄; 米田 傑; 上條 敦; 長屋 匡信; 城下 智; 小松 通治; 田中 直樹; 梅村 武司; 一條 哲也; 吉澤 要; 田中 榮司
肝臓, 50(Suppl.1), A349 - A349, Apr. 2009, Not invited - HCVはインスリン抵抗性を惹起するか 無症候性キャリアでの検討
田中 直樹; 長屋 匡信; 田中 榮司
肝臓, 49(Suppl.1), A215 - A215, Apr. 2008, Not invited - 肥満を伴わない非アルコール性脂肪肝疾患
田中 直樹; 小松 通治; 白川 晴章; 長屋 匡信; 城下 智; 小林 倫子; 新井 薫; 梅村 武司; 一條 哲也; 松本 晶博; 吉澤 要; 田中 榮司
長野県医学会雑誌, 38, 65 - 65, Mar. 2008, Not invited
Affiliated academic society
Research Themes
- 腎のPPARα機能・脂肪酸代謝の低下が腎臓病と全身臓器に及ぼす影響の解析
科学研究費助成事業, 日本学術振興会, 基盤研究(C)
信州大学
01 Apr. 2025 - 31 Mar. 2029 - Analyses of the effects of autophagy-fatty acid metabolism crosstalk on kidney dysfunction
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Shinshu University
01 Apr. 2022 - 31 Mar. 2025 - The study on novel brain aging mechanisms related to brain-specific lipids and development of preventive methods
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Shinshu University
01 Apr. 2021 - 31 Mar. 2024 - 食事中トランス脂肪酸による肝発癌促進機能の解明と予防法の開発
科学研究費補助金(基盤研究(C)), 基盤研究(C)
2019 - 2021 - Elucidation of mechanism on hepatitis C-related liver cancer exacerbation by trans-fatty acid toxicity and development of preventive method
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Shinshu University
01 Apr. 2016 - 31 Mar. 2019 - 生体異物代謝を機軸とした非アルコール性脂肪肝炎発症機構の解明
科学研究費補助金(基盤研究(C)), 基盤研究(C)
2016 - 2018 - Studies on a novel oxidative stress-reducing effect resulting from generation/excretion of sulfated glycolipids
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Shinshu University
01 Apr. 2015 - 31 Mar. 2018 - PPARα 活性化抑制を標的としたC型肝炎関連肝癌の予防法の開発
科学研究費補助金(若手研究(B)), 若手研究(B)
2009 - 2010 - Elucidation of molecular mechanisms for alcohol-dependent inflammatory disorders in digestive tract and liver and development of their preventive methods
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Shinshu University
2007 - 2008 - PPARα ノックアウトマウスを用いたアルコール性肝障害の病態解析と治療法の開発
科学研究費補助金(若手研究(B)), 若手研究(B)
2007 - 2008 - 共同研究, 米国国立衛生研究所 癌研究所 代謝部門
2004 - Global medical research and education
- Hepatocarcinogenesis caused by hepatic steatosis/steatohepatitis
- Functional foods for preventing obesity and fatty liver
- PPARaノックアウトマウスを用いたアルコール性肝障害の病態解析と治療法の開発
科学研究費補助金(若手研究(B)) - Dietary Nutrients and Gastrointestinal Disease
- Liver-adipose interaction
- Lipid metabolism and nuclear receptor
- Hepatocarcinogenesis caused by HCV core protein
- Pathogenesis of nonalcoholic steatohepatitis and development of therapeutic strategies
- Metabolomics
Social Contribution Activities
Educational activity information
Thesis guidance
Social activity information