MD., Ph. D, Shinshu University Graduate School of Medicine

Metabolism and endocrinology, Obesity, Diabetes, Fatty liver and Steatohepatitis

Physiology, Nutrition

Gastroenterology, Hepatology

Gastroenterology, Gastroenterology

Pathological biochemistry, Medical biochemistry

Tertiary education, Global Medical Research

2014
Associate Professor, Department of Metabolic Regulation, Shinshu University Graduate School of Medicine

2009 - 2012
Assistant Professor, Department of Metabolic Regulation, Shinshu University Graduate School of Medicine

2006 - 2009
Assistant Professor, Department of Metabolic Regulation, Shinshu University Graduate School of Medicine

2005 - 2006
Medical Staff in Gastroenterology, Shinshu University Hospital

2003 - 2005
Medical Staff in Internal Medicine, Showa Inan General Hospital

2002 - 2003
Medical Staff in Gastroenterology, Shinshu University Hospital

1995 - 1996
Resident in Internal Medicine, Shinshu University Hospital

2009 - 2014, Visiting fellow, Laboratory of Metabolism, National Cancer Institute, National Institutes of Health

2002, Shinshu University Graduate School of Medicine, Department of Metabolic Regulation

1995, 信州大学医学部

評議員, 日本肝臓学会

評議員, 日本消化器病学会

評議員、NSTコーディネーター, 日本病態栄養学会

2020
第23回日本病態栄養学会年次学術集会　若手研究会長賞

2015
米国国立衛生研究所, The Fellows Award for Research Excellence in NIH

2014
米国国立衛生研究所, The Fellows Award for Research Excellence in NIH

2013
米国国立衛生研究所, The Fellows Award for Research Excellence in NIH

2010
第23回日本消化器病学会奨励賞

2009
信州大学医学部松医会賞基礎分野

2008
日本肝臓学会第7回Schering-Plough Award基礎分野優秀賞

2007
ウイルス肝炎研究財団　研究助成

Function and Regulation of the Multifunctional Molecules Sulfated Glycolipids
NAKAJIMA, Takero; TANAKA, Naoki
The Shinshu Medical Journal, 71(3), 137-147, Jun. 2023

2-Step PLT16-AST44 method: Simplified liver fibrosis detection system in patients with non-alcoholic fatty liver disease
Fujimori, Naoyuki; Kimura, Takefumi; Tanaka, Naoki; Yamazaki, Tomoo; Okumura, Taiki; Kobayashi, Hiroyuki; Wakabayashi, Shun-Ichi; Yamashita, Yuki; Sugiura, Ayumi; Pham, Jonathan; Pydi, Sai P.; Sano, Kenji; Joshita, Satoru; Umemura, Takeji;
HEPATOLOGY RESEARCH, 52(4), 352-363, Apr. 2022

Serum Sulfatide Levels as a Biomarker of Active Glomerular Lesion in Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Single Center Pilot Study
Harada, Makoto; Nakajima, Takero; Yamada, Yosuke; Aomura, Daiki; Yamaguchi, Akinori; Sonoda, Kosuke; Tanaka, Naoki; Hashimoto, Koji; Kamijo, Yuji;
JOURNAL OF CLINICAL MEDICINE, 11(3), 762, Feb. 2022

Mucosal defect size predicts the adequacy of resection of <= 10 mm nonpedunculated colorectal polyps using a new cold snare polypectomy technique
Kudo, Takahiro; Horiuchi, Akira; Kyodo, Reiko; Tokita, Kazuhide; Tanaka, Naoki; Horiuchi, Ichitaro; Sano, Kenji;
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 33, E484-E489, Dec. 2021

Mechanisms of Steatosis-Derived Hepatocarcinogenesis: Lessons from HCV Core Gene Transgenic Mice
Diao, Pan; Jia, Fangping; Wang, Xiaojing; Hu, Xiao; Kimura, Takefumi; Nakajima, Takero; Aoyama, Toshifumi; Moriya, Kyoji; Koike, Kazuhiko; Tanaka, Naoki;
ENGINEERING, 7(12), 1797-1805, Dec. 2021

Impact of Dietary Fat on the Progression of Liver Fibrosis: Lessons from Animal and Cell Studies
Jia, Fangping; Hu, Xiao; Kimura, Takefumi; Tanaka, Naoki;
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(19), 10303, Oct. 2021

Pemafibrate Protects against Fatty Acid-Induced Nephropathy by Maintaining Renal Fatty Acid Metabolism
Aomura, Daiki; Harada, Makoto; Yamada, Yosuke; Nakajima, Takero; Hashimoto, Koji; Tanaka, Naoki; Kamijo, Yuji;
METABOLITES, 11(6), 372, Jun. 2021

Linked colour imaging versus white-light colonoscopy for the detection of flat colorectal lesions: A randomized controlled trial
Kudo, Takahiro; Horiuchi, Akira; Kyodo, Reiko; Horiuchi, Ichitaro; Arai, Nobuyasu; Kajiyama, Masashi; Tanaka, Naoki;
COLORECTAL DISEASE, 23(6), 1414-1420, Jun. 2021

Serum thrombospondin 2 is a novel predictor for the severity in the patients with NAFLD
Kimura, Takefumi; Tanaka, Naoki; Fujimori, Naoyuki; Yamazaki, Tomoo; Katsuyama, Takahito; Iwashita, Yuichi; Pham, Jonathan; Joshita, Satoru; Pydi, Sai P.; Umemura, Takeji;
LIVER INTERNATIONAL, 41(3), 505-514, Mar. 2021, Refereed

Role of G Protein-Coupled Receptors in Hepatic Stellate Cells and Approaches to Anti-Fibrotic Treatment of Non-Alcoholic Fatty Liver Disease
Kimura, Takefumi; Singh, Simran; Tanaka, Naoki; Umemura, Takeji;
FRONTIERS IN ENDOCRINOLOGY, 12, 773432, 2021

A saturated fatty acid-rich diet enhances hepatic lipogenesis and tumorigenesis in HCV core gene transgenic mice
Diao, Pan; Wang, Xiaojing; Jia, Fangping; Kimura, Takefumi; Hu, Xiao; Shirotori, Saki; Nakamura, Ibuki; Sato, Yoshiko; Nakayama, Jun; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Aoyama, Toshifumi; Tanaka, Naoki;
Journal of Nutritional Biochemistry, 85, Nov. 2020

Invasive liver abscess syndrome accompanied by spondylodiscitis: a case report and review of the literature
Wakabayashi SI, Kimura T, Tanaka N, Pham J, Tanaka T, Higuchi S, Kobayashi J, Umemura T, Iijima A.
Clin J Gastroenterol, 13(5), 927-934, Oct. 2020, Refereed

Metabolic Functions of G Protein-Coupled Receptors in Hepatocytes-Potential Applications for Diabetes and NAFLD
Kimura, Takefumi; Pydi, Sai P.; Pham, Jonathan; Tanaka, Naoki;
BIOMOLECULES, 10(10), Oct. 2020

Non-alcoholic fatty liver disease later diagnosed as myotonic dystrophy
Tanaka N, Kimura T, Fujimori N, Ichise Y, Sano K, Horiuchi A.
World J Hepatol. 2020 Sep 27;12(9):685-692. doi: 10.4254/wjh.v12.i9.685., 12(9), 685-692, Sep. 2020, Refereed
Lead, Corresponding

Acute liver failure with severe steatosis induced by mushroom
Wakabayashi, Shun-ichi; Kimura, Takefumi; Tanaka, Naoki;
LIVER INTERNATIONAL, 40(9), 2291-2292, Sep. 2020

Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice
Jia, Fangping; Diao, Pan; Wang, Xiaojing; Hu, Xiao; Kimura, Takefumi; Nakamuta, Makoto; Nakamura, Ibuki; Shirotori, Saki; Sato, Yoshiko; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Nakayama, Jun; Aoyama, Toshifumi; Tanaka, Naoki;
Liver Cancer, 9(5), 529-548, Sep. 2020

Polyunsaturated fatty acid deficiency affects sulfatides and other sulfated glycans in lysosomes through autophagy-mediated degradation
Wang, Yaping; Nakajima, Takero; Diao, Pan; Yamada, Yosuke; Nakamura, Kozo; Nakayama, Jun; Tanaka, Naoki; Aoyama, Toshifumi; Kamijo, Yuji;
FASEB JOURNAL, 34(7), 9594-9614, Jul. 2020

Congestive hepatopathy and acute pancreatitis as severe complications of mixed connective tissue disease
Kurihara S, Kimura T, Tanaka N, Yanagisawa T, Kobayashi H, Kanai K, Umemura T, Kobayashi M, Mori H, Wada S.
Clin J Gastroenterol, 13(3), 434-442, Jun. 2020, Refereed

PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice
Wang, Yaping; Nakajima, Takero; Gonzalez, Frank J.; Tanaka, Naoki;
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(6), Mar. 2020

Long-term luseogliflozin therapy improves histological activity of non-alcoholic steatohepatitis accompanied by type 2 diabetes mellitus
Fujimori N, Tanaka N, Kimura T, Sano K, Horiuchi A, Kato N, Takahashi Y, Kuribayashi N, Sugiura A, Yamazaki T, Joshita S, Umemura T, Matsumoto A, Tanaka E.
Clin J Gastroenterol, 13(1), 83-89, Feb. 2020, Refereed
Corresponding

A trans-fatty acid-rich diet promotes liver tumorigenesis in HCV core gene transgenic mice
Hu, Xiao; Wang, Xiaojing; Jia, Fangping; Tanaka, Naoki; Kimura, Takefumi; Nakajima, Takero; Sato, Yoshiko; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Nakayama, Jun; Aoyama, Toshifumi;
CARCINOGENESIS, 41(2), 159-170, Feb. 2020

Cold snare polypectomy: Indications, devices, techniques, outcomes and future
Horiuchi, Akira; Ikuse, Tamaki; Tanaka, Naoki;
DIGESTIVE ENDOSCOPY, 31(4), 372-377, Jul. 2019

A high-cholesterol diet promotes steatohepatitis and liver tumorigenesis in HCV core gene transgenic mice
Wang, Xiaojing; Tanaka, Naoki; Hu, Xiao; Kimura, Takefumi; Lu, Yu; Jia, Fangping; Sato, Yoshiko; Nakayama, Jun; Moriya, Kyoji; Koike, Kazuhiko; Aoyama, Toshifumi;
ARCHIVES OF TOXICOLOGY, 93(6), 1713-1725, Jun. 2019

Safety and Effectiveness of Nurse-Administered Propofol Sedation in Outpatients Undergoing Gastrointestinal Endoscopy
Sato, Masamichi; Horiuchi, Akira; Tamaki, Michio; Ichise, Yasuyuki; Kajiyama, Masashi; Yamamoto, Yuta; Tanaka, Naoki;
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 17(6), 1098-+, May 2019

Red plasma and ascites under ultraviolet A
Wakabayashi, Shun-ichi; Kimura, Takefumi; Tanaka, Naoki; Komatsu, Michiharu; Tanaka, Eiji;
LANCET GASTROENTEROLOGY & HEPATOLOGY, 4(4), 324-324, Apr. 2019

Peroxisome proliferator-activated receptor attenuates high-cholesterol diet-induced toxicity and pro-thrombotic effects in mice
Lu, Yu; Harada, Makoto; Kamijo, Yuji; Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Kyogashima, Mamoru; Gonzalez, Frank J.; Aoyama, Toshifumi;
ARCHIVES OF TOXICOLOGY, 93(1), 149-161, Jan. 2019

Gastric Emptying of Elemental Liquid Diets Versus Semisolid Diets in Bedridden Gastrostomy-fed Patients
Horiuchi, Akira; Sakai, Ryosei; Tamaki, Michio; Kajiyama, Masashi; Tanaka, Naoki; Morikawa, Akio;
JOURNAL OF CLINICAL GASTROENTEROLOGY, 53(5), 373-378, 2019

Current status, problems, and perspectives of non-alcoholic fatty liver disease research
Tanaka, Naoki; Kimura, Takefumi; Fujimori, Naoyuki; Nagaya, Tadanobu; Komatsu, Michiharu; Tanaka, Eiji;
WORLD JOURNAL OF GASTROENTEROLOGY, 25(2), 163-177, 2019

Miglitol attenuates non-alcoholic steatohepatitis in diabetic patients
Komatsu, Michiharu; Tanaka, Naoki; Kimura, Takefumi; Fujimori, Naoyuki; Sano, Kenji; Horiuchi, Akira; Sugiura, Ayumi; Yamazaki, Tomoo; Shibata, Soichiro; Joshita, Satoru; Umemura, Takeji; Matsumoto, Akihiro; Tanaka, Eiji;
HEPATOLOGY RESEARCH, 48(13), 1092-1098, Dec. 2018

Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development.
Takahashi S, Tanaka N, Fukami T, Xie C, Yagai T, Kim D, Velenosi TJ, Yan T, Krausz KW, Levi M, Gonzalez FJ.
Hepatol Commun, 2(12), 1567-1582, Oct. 2018

Emergence of anti-mitochondrial M2 antibody in patient with angioimmunoblastic T-cell lymphoma.
Wakabayashi SI, Kimura T, Tanaka N, Joshita S, Kawata K, Umemura T, Hiroshima Y, Mori H, Kobayashi H, Wada S, Tanaka E.
Clin J Gastroenterol, 11(4), 302-308, Aug. 2018

Delayed Bleeding Following Cold Snare Polypectomy for Small Colorectal Polyps in Patients Taking Antithrombotic Agents
Makino, Toshiyuki; Horiuchi, Akira; Kajiyama, Masashi; Tanaka, Naoki; Sano, Kenji; Maetani, Iruru;
JOURNAL OF CLINICAL GASTROENTEROLOGY, 52(6), 502-507, Jul. 2018

Salmonella Enteritidis cholecystitis with chronic granulomatous disease.
Yamashita Y, Kimura T, Tanaka N, Yazaki M, Itagaki T, Joshita S, Umemura T, Matsumoto A, Mori H, Wada S, Tanaka E.
IDCases, 12, 12:49-52, May 2018

Mild drinking habit is a risk factor for hepatocarcinogenesis in non-alcoholic fatty liver disease with advanced fibrosis
Kimura, Takefumi; Tanaka, Naoki; Fujimori, Naoyuki; Sugiura, Ayumi; Yamazaki, Tomoo; Joshita, Satoru; Komatsu, Michiharu; Umemura, Takeji; Matsumoto, Akihiro; Tanaka, Eiji;
WORLD JOURNAL OF GASTROENTEROLOGY, 24(13), 1440-1450, Apr. 2018

Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non-alcoholic fatty liver disease
Fujimori, Naoyuki; Umemura, Takeji; Kimura, Takefumi; Tanaka, Naoki; Sugiura, Ayumi; Yamazaki, Tomoo; Joshita, Satoru; Komatsu, Michiharu; Usami, Yoko; Sano, Kenji; Igarashi, Koji; Matsumoto, Akihiro; Tanaka, Eiji;
WORLD JOURNAL OF GASTROENTEROLOGY, 24(11), 1239-1249, Mar. 2018

Hepatic Angiosarcoma with Kasabach-Merritt Phenomenon: A Case Report and Review of the Literature
Fujii, Fumika; Kimura, Takefumi; Tanaka, Naoki; Kubota, Daisuke; Sugiura, Ayumi; Umemura, Takeji; Wada, Shuichi; Tanaka, Eiji;
ANNALS OF HEPATOLOGY, 17(4), 655-660, 2018

Growth arrest and DNA damage-inducible 45 alpha protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet
Tanaka, Naoki; Takahashi, Shogo; Hu, Xiao; Lu, Yu; Fujimori, Naoyuki; Golla, Srujana; Fang, Zhong-Ze; Aoyama, Toshifumi; Krausz, Kristopher W.; Gonzalez, Frank J.;
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1863(12), 3170-3182, Dec. 2017

Targeting nuclear receptors for the treatment of fatty liver disease
Tanaka, Naoki; Aoyama, Toshifumi; Kimura, Shioko; Gonzalez, Frank J.;
PHARMACOLOGY & THERAPEUTICS, 179, 142-157, Nov. 2017

Association between lower air pressure and the onset of ischemic colitis: a case-control study
Kimura, Takefumi; Shinji, Akihiro; Tanaka, Naoki; Koinuma, Masayoshi; Yamaura, Maki; Nagaya, Tadanobu; Joshita, Satoru; Komatsu, Michiharu; Umemura, Takeji; Horiuchi, Akira; Wada, Shuichi; Tanaka, Eiji;
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 29(9), 1071-1078, Sep. 2017

Farnesoid X Receptor Protects Against Low-Dose Carbon Tetrachloride-Induced Liver Injury Through the Taurocholate-JNK Pathway
Takahashi, Shogo; Tanaka, Naoki; Golla, Srujana; Fukami, Tatsuki; Krausz, Kristopher W.; Polunas, Marianne A.; Weig, Blair C.; Masuo, Yusuke; Xie, Cen; Jiang, Changtao; Gonzalez, Frank J.;
Toxicological Sciences, 158(2), 334-346, Aug. 2017

Decreased Fatty Acid beta-Oxidation Is the Main Cause of Fatty Liver Induced by Polyunsaturated Fatty Acid Deficiency in Mice
Nakajima, Takero; Yang, Yang; Lu, Yu; Kamijo, Yuji; Yamada, Yosuke; Nakamura, Kozo; Koyama, Masahiro; Yamaguchi, Shohei; Sugiyama, Eiko; Tanaka, Naoki; Aoyama, Toshifumi;
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 242(3), 229-239, Jul. 2017

Role of the lipid-regulated NF-kappa B/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury
Fang, Zhong-Ze; Tanaka, Naoki; Lu, Dan; Jiang, Chang-Tao; Zhang, Wei-Hua; Zhang, Chunze; Du, Zuo; Fu, Zhi-Wei; Gao, Peng; Cao, Yun-Feng; Sun, Hong-Zhi; Zhu, Zhi-Tu; Cai, Yan; Krausz, Kristopher W.; Yao, Zhi; Gonzalez, Frank J.;
ARCHIVES OF TOXICOLOGY, 91(5), 2235-2244, May 2017

Clinicopathological characteristics of non-B non-C hepatocellular carcinoma without past hepatitis B virus infection
Kimura, Takefumi; Kobayashi, Akira; Tanaka, Naoki; Sano, Kenji; Komatsu, Michiharu; Fujimori, Naoyuki; Yamazaki, Tomoo; Shibata, Soichiro; Ichikawa, Yuki; Joshita, Satoru; Umemura, Takeji; Matsumoto, Akihiro; Horiuchi, Akira; Mori, Hiromitsu; Wada, Shuichi; Kiyosawa, Kendo; Miyagawa, Shin-ichi; Tanaka, Eiji;
HEPATOLOGY RESEARCH, 47(5), 405-418, Apr. 2017

PPAR alpha protects against trans-fatty-acid-containing diet-induced steatohepatitis
Hu, Xiao; Tanaka, Naoki; Guo, Ran; Lu, Yu; Nakajima, Takero; Gonzalez, Frank J.; Aoyama, Toshifumi;
Journal of Nutritional Biochemistry, 39, 77-85, Jan. 2017

Association between endotoxemia and histological features of nonalcoholic fatty liver disease
Kitabatake, Hiroyuki; Tanaka, Naoki; Fujimori, Naoyuki; Komatsu, Michiharu; Okubo, Ayaka; Kakegawa, Kyogo; Kimura, Takefumi; Sugiura, Ayumi; Yamazaki, Tomoo; Shibata, Soichiro; Ichikawa, Yuki; Joshita, Satoru; Umemura, Takeji; Matsumoto, Akihiro; Koinuma, Masayoshi; Sano, Kenji; Aoyama, Toshifumi; Tanaka, Eiji;
WORLD JOURNAL OF GASTROENTEROLOGY, 23(4), 712-722, 2017

Vonoprazan-Based Regimen Is More Useful than PPI-Based One as a First-Line Helicobacter pylori Eradication: A Randomized Controlled Trial
Maruyama, Masafumi; Tanaka, Naoki; Kubota, Daisuke; Miyajima, Masayuki; Kimura, Takefumi; Tokutake, Koujiro; Imai, Ryujiro; Fujisawa, Toru; Mori, Hiromitsu; Matsuda, Yoshiaki; Wada, Shuichi; Horiuchi, Akira; Kiyosawa, Kendo;
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2017

Glycyrrhizin and glycyrrhetinic acid inhibits alpha-naphthyl isothiocyanate-induced liver injury and bile acid cycle disruption
Wang, Haina; Fang, Zhong-Ze; Meng, Ran; Cao, Yun-Feng; Tanaka, Naoki; Krausz, Kristopher W.; Gonzalez, Frank J.;
Toxicology, 386, 133-142, 2017

Age-dependent PPAR alpha activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene
Tian, Yangyang; Yang, Yang; Zhang, Xiaowei; Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Kamijo, Yuji; Lu, Yu; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Aoyama, Toshifumi;
GLYCOCONJUGATE JOURNAL, 33(6), 927-936, Dec. 2016

PPAR alpha-dependent cholesterol/testosterone disruption in Leydig cells mediates 2,4-dichlorophenoxyacetic acid-induced testicular toxicity in mice
Harada, Yukiko; Tanaka, Naoki; Ichikawa, Motoki; Kamijo, Yuji; Sugiyama, Eiko; Gonzalez, Frank J.; Aoyama, Toshifumi;
ARCHIVES OF TOXICOLOGY, 90(12), 3061-3071, Dec. 2016

Activation of PPAR alpha by Fatty Acid Accumulation Enhances Fatty Acid Degradation and Sulfatide Synthesis
Yang, Yang; Feng, Yuyao; Zhang, Xiaowei; Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Kamijo, Yuji; Aoyama, Toshifumi;
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 240(2), 113-122, Oct. 2016

Controlled attenuation parameter is correlated with actual hepatic fat content in patients with non-alcoholic fatty liver disease with none-to-mild obesity and liver fibrosis
Fujimori, Naoyuki; Tanaka, Naoki; Shibata, Soichiro; Sano, Kenji; Yamazaki, Tomoo; Sekiguchi, Tomohiro; Kitabatake, Hiroyuki; Ichikawa, Yuki; Kimura, Takefumi; Komatsu, Michiharu; Umemura, Takeji; Matsumoto, Akihiro; Tanaka, Eiji;
HEPATOLOGY RESEARCH, 46(10), 1019-1027, Sep. 2016

Comparison between endoscopic mucosal resection and hot snare resection of large nonpedunculated colorectal polyps: a randomized trial
Horiuchi, Akira; Makino, Toshiyuki; Kajiyama, Masashi; Tanaka, Naoki; Sano, Kenji; Graham, David Y.;
ENDOSCOPY, 48(7), 646-651, Jul. 2016

Irinotecan (CPT-11)-induced elevation of bile acids potentiates suppression of IL-10 expression
Fang, Zhong-Ze; Zhang, Dunfang; Cao, Yun-Feng; Xie, Cen; Lu, Dan; Sun, Dong-Xue; Tanaka, Naoki; Jiang, Changtao; Chen, Qianming; Chen, Yu; Wang, Haina; Gonzalez, Frank J.;
Toxicology and Applied Pharmacology, 291, 21-27, 2016

Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans
Xu, Ming-Jiang; Cai, Yan; Wang, Hua; Altamirano, Jose; Chang, Binxia; Bertola, Adeline; Odena, Gemma; Lu, Jim; Tanaka, Naoki; Matsusue, Kimihiko; Matsubara, Tsutomu; Mukhopadhyay, Partha; Kimura, Shioko; Pacher, Pal; Gonzalez, Frank J.; Bataller, Ramon; Gao, Bin;
GASTROENTEROLOGY, 149(4), 1030-U367, Oct. 2015

Prospective, randomized comparison of 2 methods of cold snare polypectomy for small colorectal polyps
Horiuchi, Akira; Hosoi, Kenji; Kajiyama, Masashi; Tanaka, Naoki; Sano, Kenji; Graham, David Y.;
GASTROINTESTINAL ENDOSCOPY, 82(4), 686-692, Oct. 2015

St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling
Manna, Soumen K.; Golla, Srujana; Golla, Jaya Prakash; Tanaka, Naoki; Cai, Yan; Takahashi, Shogo; Krausz, Kristopher W.; Matsubara, Tsutomu; Korboukh, Ilia; Gonzalez, Frank J.;
CANCER PREVENTION RESEARCH, 8(9), 786-795, Sep. 2015

Primary hepatocellular carcinoma in a patient with neurofibromatosis type I
Kimura, Takefumi; Tanaka, Naoki; Umemura, Takeji; Tanaka, Eiji;
LIVER INTERNATIONAL, 35(8), 2057-2058, Aug. 2015

Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet
Tanaka, Naoki; Takahashi, Shogo; Zhang, Yuan; Krausz, Kristopher W.; Smith, Philip B.; Patterson, Andrew D.; Gonzalez, Frank J.;
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1852(7), 1242-1252, Jul. 2015

Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation
Zhang, Limin; Nichols, Robert G.; Correll, Jared; Murray, Iain A.; Tanaka, Naoki; Smith, Philip B.; Hubbard, Troy D.; Sebastian, Aswathy; Albert, Istvan; Hatzakis, Emmanuel; Gonzalez, Frank J.; Perdew, Gary H.; Patterson, Andrew D.;
ENVIRONMENTAL HEALTH PERSPECTIVES, 123(7), 679-688, Jul. 2015

Steatogenesis in adult-onset type II citrullinemia is associated with down-regulation of PPAR alpha
Komatsu, Michiharu; Kimura, Takefumi; Yazaki, Masahide; Tanaka, Naoki; Yang, Yang; Nakajima, Takero; Horiuchi, Akira; Fang, Zhong-Ze; Joshita, Satoru; Matsumoto, Akihiro; Umemura, Takeji; Tanaka, Eiji; Gonzalez, Frank J.; Ikeda, Shu-Ichi; Aoyama, Toshifumi;
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1852(3), 473-481, Mar. 2015

Comparison of newly found polyps after removal of small colorectal polyps with cold or hot snare polypectomy
Horiuchi, Akira; Makino, Toshiyuki; Ichise, Yasuyuki; Kajiyama, Masashi; Kato, Naoyuki; Tanaka, Naoki;
ACTA GASTRO-ENTEROLOGICA BELGICA, 78(4), 406-410, 2015

Metabolic mapping of A(3) adenosine receptor agonist MRS5980
Fang, Zhong-Ze; Tosh, Dilip K.; Tanaka, Naoki; Wang, Haina; Krausz, Kristopher W.; O'Connor, Robert; Jacobson, Kenneth A.; Gonzalez, Frank J.;
Biochemical Pharmacology, 97(2), 215-223, 2015

Adipocyte-specific Disruption of Fat-specific Protein 27 Causes Hepatosteatosis and Insulin Resistance in High-fat Diet-fed Mice
Tanaka, Naoki; Takahashi, Shogo; Matsubara, Tsutomu; Jiang, Changtao; Sakamoto, Wataru; Chanturiya, Tatyana; Teng, Ruifeng; Gavrilova, Oksana; Gonzalez, Frank J.;
JOURNAL OF BIOLOGICAL CHEMISTRY, 290(5), 3092-3105, 2015

Helicobacter pylori-negative Differentiated Adenocarcinoma of the Stomach
Nagaya, Tadanobu; Tanaka, Naoki; Iwaya, Yugo; Jimbo, Yoko; Tatai, Toshiharu; Ito, Tetsuya; Seki, Ayako; Suzawa, Kenichi; Ochi, Yasuhide; Hara, Etsuo; Takata, Manabu; Otsuki, Toshiaki; Iwaya, Mai; Hosaka, Noriko; Arakura, Norikazu; Tanaka, Eiji; Hasebe, Osamu;
INTERNAL MEDICINE, 54(22), 2857-2862, 2015

Activation of Intestinal Human Pregnane X Receptor Protects against Azoxymethane/Dextran Sulfate Sodium-Induced Colon Cancer
Cheng, Jie; Fang, Zhong-Ze; Nagaoka, Kenjiro; Okamoto, Minoru; Qu, Aijuan; Tanaka, Naoki; Kimura, Shioko; Gonzalez, Frank J.;
Journal of Pharmacology and Experimental Therapeutics, 351(3), 559-567, Dec. 2014

Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet
Tanaka, Naoki; Takahashi, Shogo; Fang, Zhong-Ze; Matsubara, Tsutomu; Krausz, Kristopher W.; Qu, Aijuan; Gonzalez, Frank J.;
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1841(11), 1596-1607, Nov. 2014

Biliary stenting as alternative therapy to stone clearance in elderly patients with bile duct stones
Horiuchi, Akira; Kajiyama, Masashi; Ichise, Yasuyuki; Tada, Haruyo; Fujiwara, Naoyuki; Tanaka, Naoki;
ACTA GASTRO-ENTEROLOGICA BELGICA, 77(3), 297-301, Sep. 2014

Laparoscopic findings of congenital hepatic fibrosis: A case report and review of the published work
Komatsu, Michiharu; Tanaka, Naoki; Shibata, So-Ichirou; Kimura, Takefumi; Ichikawa, Yuki; Morita, Susumu; Joshita, Satoru; Nagaya, Tadanobu; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Tanaka, Eiji;
HEPATOLOGY RESEARCH, 44(7), 818-824, Jul. 2014

Biomarkers of Coordinate Metabolic Reprogramming in Colorectal Tumors in Mice and Humans
Manna, Soumen K.; Tanaka, Naoki; Krausz, Kristopher W.; Haznadar, Majda; Xue, Xiang; Matsubara, Tsutomu; Bowman, Elise D.; Fearon, Eric R.; Harris, Curtis C.; Shah, Yatrik M.; Gonzalez, Frank J.;
GASTROENTEROLOGY, 146(5), 1313-1324, May 2014

In vivo effects of the pure aryl hydrocarbon receptor antagonist GNF-351 after oral administration are limited to the gastrointestinal tract
Fang, Zhong-Ze; Krausz, Kristopher W.; Nagaoka, Kenjiro; Tanaka, Naoki; Gowda, Krishne; Amin, Shantu G.; Perdew, Gary H.; Gonzalez, Frank J.;
British Journal of Pharmacology, 171(7), 1735-1746, Apr. 2014

Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice
Cheng, Jie; Fang, Zhong-Ze; Kim, Jung-Hwan; Krausz, Kristopher W.; Tanaka, Naoki; Chiang, John Y. L.; Gonzalez, Frank J.;
Journal of Lipid Research, 55(3), 455-465, Mar. 2014

Removal of small colorectal polyps in anticoagulated patients: a prospective randomized comparison of cold snare and conventional polypectomy
Horiuchi, Akira; Nakayama, Yoshiko; Kajiyama, Masashi; Tanaka, Naoki; Sano, Kenji; Graham, David Y.;
GASTROINTESTINAL ENDOSCOPY, 79(3), 417-423, Mar. 2014

Role of Myc in hepatocellular proliferation and hepatocarcinogenesis
Qu, Aijuan; Jiang, Changtao; Cai, Yan; Kim, Jung-Hwan; Tanaka, Naoki; Ward, Jerrold M.; Shah, Yatrik M.; Gonzalez, Frank J.;
JOURNAL OF HEPATOLOGY, 60(2), 331-338, Feb. 2014

Chronic ethanol consumption decreases serum sulfatide levels by suppressing hepatic cerebroside sulfotransferase expression in mice
Kanbe, Hiroki; Kamijo, Yuji; Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Wang, Lixuan; Fang, Zhong-Ze; Hara, Atsushi; Gonzalez, Frank J.; Aoyama, Toshifumi;
ARCHIVES OF TOXICOLOGY, 88(2), 367-379, Feb. 2014

Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-kappa B and STAT3 signaling
Liu, Aiming; Tanaka, Naoki; Sun, Lu; Guo, Bin; Kim, Jung-Hwan; Krausz, Kristopher W.; Fang, Zhongze; Jiang, Changtao; Yang, Julin; Gonzalez, Frank J.;
CHEMICO-BIOLOGICAL INTERACTIONS, 223, 80-86, 2014

Improving quality measures in colonoscopy and its therapeutic intervention
Horiuchi, Akira; Tanaka, Naoki;
WORLD JOURNAL OF GASTROENTEROLOGY, 20(36), 13027-13034, 2014

PPAR alpha-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate
Qi, Yunpeng; Jiang, Changtao; Tanaka, Naoki; Krausz, Kristopher W.; Brocker, Chad N.; Fang, Zhong-Ze; Bredell, Bryce X.; Shah, Yatrik M.; Gonzalez, Frank J.;
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 307(5), G564-G573, 2014

Herb-drug interaction prediction based on the high specific inhibition of andrographolide derivatives towards UDP-glucuronosyltransferase (UGT) 2B7
Ma, Hai-Ying; Sun, Dong-Xue; Cao, Yun-Feng; Ai, Chun-Zhi; Qu, Yan-Qing; Hu, Cui-Min; Jiang, Changtao; Dong, Pei-Pei; Sun, Xiao-Yu; Hong, Mo; Tanaka, Naoki; Gonzalez, Frank J.; Ma, Xiao-Chi; Fang, Zhong-Ze;
Toxicology and Applied Pharmacology, 277(1), 86-94, 2014

A model of in vitro UDP-glucuronosyltransferase inhibition by bile acids predicts possible metabolic disorders
Fang, Zhong-Ze; He, Rong-Rong; Cao, Yun-Feng; Tanaka, Naoki; Jiang, Changtao; Krausz, Kristopher W.; Qi, Yunpeng; Dong, Pei-Pei; Ai, Chun-Zhi; Sun, Xiao-Yu; Hong, Mo; Ge, Guang-Bo; Gonzalez, Frank J.; Ma, Xiao-Chi; Sun, Hong-Zhi;
Journal of Lipid Research, 54(12), 3334-3344, Dec. 2013

Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum
Fang, Zhong-Ze; Krausz, Kristopher W.; Tanaka, Naoki; Li, Fei; Qu, Aijuan; Idle, Jeffrey R.; Gonzalez, Frank J.
ARCHIVES OF TOXICOLOGY, 87(11), 1975-1987, Nov. 2013

Peroxisome proliferator-activated receptor alpha mediates enhancement of gene expression of cerebroside sulfotransferase in several murine organs
Nakajima, Takero; Kamijo, Yuji; Huang Yuzhe; Kimura, Takefumi; Tanaka, Naoki; Sugiyama, Eiko; Nakamura, Kozo; Kyogashima, Mamoru; Hara, Atsushi; Aoyama, Toshifumi;
GLYCOCONJUGATE JOURNAL, 30(6), 553-560, Aug. 2013

Safety and Effectiveness of Low-Dose Propofol Sedation During and After Esophagogastroduodenoscopy in Child A and B Cirrhotic Patients
Tanaka, Naoki; Horiuchi, Akira; Nakayama, Yoshiko; Katsuyama, Yoshihiko; Isobe, Masatsugu; Aoyama, Toshifumi; Tanaka, Eiji; Ohmori, Shigeru
DIGESTIVE DISEASES AND SCIENCES, 58(5), 1383-1389, May 2013

TGF-beta-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury
Matsubara, Tsutomu; Tanaka, Naoki; Sato, Misako; Kang, Dong Wook; Krausz, Kristopher W.; Flanders, Kathleen C.; Ikeda, Kazuo; Luecke, Hans; Wakefield, Lalage M.; Gonzalez, Frank J.
Journal of Lipid Research, 53(12), 2698-2707, Dec. 2012

Metabolomics Identifies an Inflammatory Cascade Involved in Dioxin- and Diet-Induced Steatohepatitis
Matsubara, Tsutomu; Tanaka, Naoki; Krausz, Kristopher W.; Manna, Soumen K.; Kang, Dong Wook; Anderson, Erik R.; Luecke, Hans; Patterson, Andrew D.; Shah, Yatrik M.; Gonzalez, Frank J.
Cell Metabolism, 16(5), 634-644, 07 Nov. 2012

Metabolomics reveals an essential role for peroxisome proliferator-activated receptor alpha in bile acid homeostasis
Li, Fei; Patterson, Andrew D.; Krausz, Kristopher W.; Tanaka, Naoki; Gonzalez, Frank J.
Journal of Lipid Research, 53(8), 1625-1635, Aug. 2012

Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis
Tanaka, Naoki; Matsubara, Tsutomu; Krausz, Kristopher W.; Patterson, Andrew D.; Gonzalez, Frank J.
Hepatology, 56(1), 118-129, Jul. 2012

Clinical Characteristics of Young-Onset Ischemic Colitis
Kimura, Takefumi; Shinji, Akihiro; Horiuchi, Akira; Tanaka, Naoki; Nagaya, Tadanobu; Shigeno, Takashi; Nakamura, Naoshi; Komatsu, Michiharu; Umemura, Takeji; Arakura, Norikazu; Matsumoto, Akihiro; Tanaka, Eiji
DIGESTIVE DISEASES AND SCIENCES, 57(6), 1652-1659, Jun. 2012

PPAR alpha is down-regulated following liver transplantation in mice
Nakagawa, Kan; Tanaka, Naoki; Morita, Miwa; Sugioka, Atsushi; Miyagawa, Shin-ichi; Gonzalez, Frank J.; Aoyama, Toshifumi
JOURNAL OF HEPATOLOGY, 56(3), 586-594, Mar. 2012

Clinical characteristics of de novo nonalcoholic fatty liver disease following pancreaticoduodenectomy
Tanaka, Naoki; Horiuchi, Akira;Yokoyama, Takahide; Kaneko, Gengo; Horigome, Naoto; Yamaura, Takahiro; Nagaya, Tadanobu; Komatsu, Michiharu; Sano, Kenji; Miyagawa, Shin-ichi; Aoyama, Toshifumi; Tanaka, Eiji
JOURNAL OF GASTROENTEROLOGY, 46(6), 758-768, Jun. 2011

Lithocholic Acid Disrupts Phospholipid and Sphingolipid Homeostasis Leading to Cholestasis in Mice
Matsubara, Tsutomu; Tanaka, Naoki; Patterson, Andrew D.; Cho, Joo-Youn; Krausz, Kristopher W.; Gonzalez, Frank J.
Hepatology, 53(4), 1282-1293, Apr. 2011

Accurate and simple method for quantification of hepatic fat content using magnetic resonance imaging: a prospective study in biopsy-proven nonalcoholic fatty liver disease
Hatta, Tomoko; Fujinaga, Yasunari; Kadoya, Masumi; Ueda, Hitoshi; Murayama, Hiroaki; Kurozumi, Masahiro; Ueda, Kazuhiko; Komatsu, Michiharu; Nagaya, Tadanobu; Joshita, Satoru; Kodama, Ryo; Tanaka, Eiji; Uehara, Tsuyoshi; Sano, Kenji; Tanaka, Naoki
JOURNAL OF GASTROENTEROLOGY, 45(12), 1263-1271, Dec. 2010

Eicosapentaenoic acid improves hepatic steatosis independent of PPAR alpha activation through inhibition of SREBP-1 maturation in mice
Tanaka, Naoki; Zhang, Xiuguo; Sugiyama, Eiko; Kono, Hiroyuki; Horiuchi, Akira; Nakajima, Takero; Kanbe, Hiroki; Tanaka, Eiji; Gonzalez, Frank J.; Aoyama, Toshifumi
Biochemical Pharmacology, 80(10), 1601-1612, 15 Nov. 2010

Down-regulation of SREBP-1c is associated with the development of burned-out NASH
Nagaya, Tadanobu; Tanaka, Naoki; Suzuki, Takefumi; Sano, Kenji; Horiuchi, Akira; Komatsu, Michiharu; Nakajima, Takero; Nishizawa, Tomoko; Joshita, Satoru; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Nakayama, Jun; Tanaka, Eiji; Aoyama, Toshifumi
JOURNAL OF HEPATOLOGY, 53(4), 724-731, Oct. 2010

Serum Fragmented Cytokeratin 18 Levels Reflect the Histologic Activity Score of Nonalcoholic Fatty Liver Disease More Accurately Than Serum Alanine Aminotransferase Levels
Tsutsui, Masaru; Tanaka, Naoki; Kawakubo, Masatomo; Sheena, Yo; Horiuchi, Akira; Komatsu, Michiharu; Nagaya, Tadanobu; Joshita, Satoru; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Aoyama, Toshifumi; Tanaka, Eiji; Sano, Kenji
JOURNAL OF CLINICAL GASTROENTEROLOGY, 44(6), 440-447, Jul. 2010

Nonalcoholic fatty liver disease in Japanese junior high school students: its prevalence and relationship to lifestyle habits
Tsuruta, Goro; Tanaka, Naoki; Hongo, Minoru; Komatsu, Michiharu; Horiuchi, Akira; Hamamoto, Kaeko; Iguchi, Chieko; Nakayama, Yoshiko; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Aoyama, Toshifumi; Tanaka, Eiji
JOURNAL OF GASTROENTEROLOGY, 45(6), 666-672, Jun. 2010

一般中学生の高尿酸血症と生活習慣病との関連
本郷 実,日高 宏哉,阪口 しげ子,市川 元基,池田 宇一,田中 直樹,鶴田 悟郎,小池 健一
痛風と核酸代謝 = Gout and nucleic acid metabolism, 33(1), 17-26, 01 Jul. 2009

Polyenephosphatidylcholine prevents alcoholic liver disease in PPAR alpha-null mice through attenuation of increases in oxidative stress
Okiyama, Wataru; Tanaka, Naoki; Nakajima, Tamie; Tanaka, Eiji; Kiyosawa, Kendo; Gonzalez, Frank J.; Aoyama, Toshifumi
JOURNAL OF HEPATOLOGY, 50(6), 1236-1246, Jun. 2009

Efficacy and safety of addition of minor bloodletting (petit phlebotomy) in hepatitis C virus-infected patients receiving regular glycyrrhizin injections
Tanaka, Naoki; Horiuchi, Akira; Yamaura, Takahiro; Komatsu, Michiharu; Yokoyama, Takahide; Okaniwa, Shinji; Nagaya, Tadanobu; Yoshizawa, Kaname; Kiyosawa, Kendo; Aoyama, Toshifumi; Tanaka, Eiji
JOURNAL OF GASTROENTEROLOGY, 44(6), 577-582, Jun. 2009

Bezafibrate at Clinically Relevant Doses Decreases Serum/Liver Triglycerides via Down-Regulation of Sterol Regulatory Element-Binding Protein-1c in Mice: A Novel Peroxisome Proliferator-Activated Receptor alpha-Independent Mechanism
Nakajima, Takero; Tanaka, Naoki; Kanbe, Hiroki; Hara, Atsushi; Kamijo, Yuji; Zhang, Xiaowei; Gonzalez, Frank J.; Aoyama, Toshifumi
MOLECULAR PHARMACOLOGY, 75(4), 782-792, Apr. 2009

Hepatitis C Virus, Splenic Vein Thrombosis, and Lymphoma
Tanaka, Naoki; Yokoyama, Takahide; Horiuchi, Akira
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 7(2), XXIV-XXIV, Feb. 2009

広範囲の肝実質の脱落により奇異な肝形態を呈し自己免疫性肝炎が疑われた1例
城下 智,一條 哲也,吉澤 要,福島 万奈,小松 通治,新井 薫,田中 直樹,梅村 武司,松本 晶博,田中 榮司
日本消化器内視鏡学会雑誌 = Gastroenterological endoscopy, 51(1), 48-54, 20 Jan. 2009

Peroxisome Proliferator-Activated Receptor Alpha (PPARα) : The Association with Pathogenesis of Fatty Liver Disease
TANAKA, Naoki; AOYAMA, Toshifumi
The Shinshu Medical Journal, 56(6), 347-358, Dec. 2008

Citrin deficiency as a cause of chronic liver disorder mimicking non-alcoholic fatty liver disease
Komatsu, Michiharu; Yazaki, Masahide; Tanaka, Naoki; Sano, Kenji; Hashimoto, Etsuko; Taker, Yo-ichi; Song, Yuan-Zong; Tanaka, Eiji; Kiyosawa, Kendo; Saheki, Takeyori; Aoyama, Toshifumi; Kobayashi, Keiko
JOURNAL OF HEPATOLOGY, 49(5), 810-820, Nov. 2008

Insulin resistance and hepatitis C virus: a case-control study of non-obese, non-alcoholic and non-steatotic hepatitis virus carriers with persistently normal serumaminotransferase
Tanaka, Naoki; Nagaya, Tadanobu; Komatsu, Michiharu; Horiuchi, Akira; Tsuruta, Goro; Shirakawa, Haruaki; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Aoyama, Toshifumi; Kiyosawa, Kendo; Tanaka, Eiji
LIVER INTERNATIONAL, 28(8), 1104-1111, Sep. 2008

Cholesterol-lowering effectof bezafibrate is independent of peroxisome proliferator-activated receptor activation in mice
Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Kamijo, Yuji; Hara, Atsushi; Hu, Rui; Li, Gang; Li, Yufeng; Nakamura, Kozo; Gonzalez, Frank J.; Aoyama, Toshifumi
Biochemical Pharmacology, 76(1), 108-119, 01 Jul. 2008

Highly purified eicosapentaenoic acid treatment improves nonalcoholic steatohepatitis
Tanaka, Naoki; Sano, Kenji; Horiuchi, Akira; Tanaka, Eiji; Kiyosawa, Kendo; Aoyama, Toshifumi
JOURNAL OF CLINICAL GASTROENTEROLOGY, 42(4), 413-418, Apr. 2008

PPAR alpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice
Tanaka, Naoki; Moriya, Kyoji; Kiyosawa, Kendo; Koike, Kazuhiko; Gonzalez, Frank J.; Aoyama, Toshifurni
JOURNAL OF CLINICAL INVESTIGATION, 118(2), 683-694, Feb. 2008

Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: Implications for HCV-associated hepatocarcinogenesis
Tanaka, Naoki; Moriya, Kyoji; Kiyosawa, Kendo; Koike, Kazuhiko; Aoyama, Toshifumi
INTERNATIONAL JOURNAL OF CANCER, 122(1), 124-131, 01 Jan. 2008

Pancreatic exocrine insufficiency: A rare cause of nonalcoholic steatohepatitis
Tanaka, Naoki; Horiuchi, Akira; Yokoyama, Takahide; Kawa, Shigeyuki; Kiyosawa, Kendo
AMERICAN JOURNAL OF GASTROENTEROLOGY, 103(1), 245-246, Jan. 2008

腹壁への浸潤が疑われ, 画像検査が診断の契機となった肝放線菌症の1例
武藤 英知,一條 哲也,小林 倫子,田中 直樹,梅村 武司,小松 通治,松本 晶博,吉澤 要,田中 榮司,上田 和彦,角谷 眞澄,清澤 研道
肝臓 = ACTA HEPATOLOGICA JAPONICA, 48(11), 553-558, 25 Nov. 2007

A lean man with nonalcoholic fatty liver disease
Tanaka, Naoki; Yazaki, Masahide; Kobayashi, Keiko
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 5(3), XXXII-XXXII, Mar. 2007

Efficacy and safety of 6-month iron reduction therapy in patients with hepatitis C virus-related cirrhosis: a pilot study
Tanaka, Naoki; Horiuchi, Akira; Yamaura, Takahiro; Komatsu, Michiharu; Tanaka, Eiji; Kiyosawa, Kendo
JOURNAL OF GASTROENTEROLOGY, 42(1), 49-55, Jan. 2007

Useful parameters for distinguishing nonalcoholic steatohepatitis with mild steatosis from cryptogenic chronic hepatitis in the Japanese population
Tanaka, Naoki; Tanaka, Eiji; Sheena, Yo;Komatsu, Michiharu; Okiyama, Wataru; Misawa, Noriko; Muto, Hidetomo; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Horiuchi, Akira; Kiyosawa, Kendo
LIVER INTERNATIONAL, 26(8), 956-963, Oct. 2006

Peroxisome proliferator-activated receptor alpha-independent peroxisome proliferation
Zhang, Xiuguo; Tanaka, Naoki; Nakajuna, Takero; Kamijo, Yuji; Gonzalez, Frank J.; Aoyama, Toshifumi
Biochemical and biophysical research communications, 346(4), 1307-1311, 11 Aug. 2006

Laparoscopic findings in patients with nonalcoholic steatohepatitis
Tanaka, N; Ichijo, T; Okiyama, W; Mutou, H; Misawa, N; Matsumoto, A; Yoshizawa, K; Tanaka, E; Kiyosawa, K
LIVER INTERNATIONAL, 26(1), 32-38, Feb. 2006

Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage
Nakajima, T; Kamijo, Y; Tanaka, N; Sugiyama, E; Tanaka, E; Kiyosawa, K; Fukushima, Y; Peters, JM; Gonzalez, FJ; Aoyama, T
Hepatology, 40(4), 972-980, Oct. 2004

Phlebotomy: a promising treatment for chronic hepatitis C
Tanaka, N; Kiyosawa, K
JOURNAL OF GASTROENTEROLOGY, 39(6), 601-603, Jun. 2004

Ribavirin-induced pure red-cell aplasia during treatment of chronic hepatitis C.
Tanaka, N; Ishida, F; Tanaka, E
NEW ENGLAND JOURNAL OF MEDICINE, 350(12), 1264-1265, 18 Mar. 2004

In vivo stabilization of nuclear retinoid X receptor alpha in the presence of peroxisome proliferator-activated receptor alpha
Tanaka,N; Hora, K; Makishima, H; Kamijo, Y; Kiyosawa, K; Gonzalez, FJ; Aoyama, T
FEBS Letters, 543(1-3), 120-124, 22 May 2003

Development of hepatocellular carcinoma after longterm sustained complete response to interferon therapy: what is the mechanism?
Tanaka, N; Kiyosawa, K
JOURNAL OF GASTROENTEROLOGY, 38(4), 417-419, Apr. 2003

非アルコール性脂肪性肝炎
田中 直樹,清澤 研道
肝臓, 43(12), 539-549, 25 Dec. 2002

非アルコール性脂肪肝炎の発症機構とPPAR
田中 直樹,青山 俊文
日本消化器病學會雜誌 = The Japanese journal of gastro-enterology, 99(6), 563-569, 05 Jun. 2002

トピックス 4.Peroxisome proliferator-activated receptor(PPAR)
田中 直樹,青山 俊文
日本内科学会雑誌, 90(10), 2033-2039, 10 Oct. 2001

Initiation of enzyme replacement therapy for an adult patient with asymptomatic type 1 Gaucher's disease
Tanaka, N; Saito, H; Ito, T; Momose, K; Ishida, F; Hora, K; Kiyosawa, K; Ida, H
INTERNAL MEDICINE, 40(8), 716-721, Aug. 2001

Back pain out of the blue in a haemodialysis patient
Tanaka, N; Kasahara, H; Yoshie, T; Hora, K; Kiyosawa, K
NEPHROLOGY DIALYSIS TRANSPLANTATION, 14(7), 1792-1794, Jul. 1999

人間機能・形態学概論
Shinshu University

人間機能・形態学概論
Shinshu University

人間機能・形態学概論
Shinshu University

人間機能・形態学概論
Shinshu University

人間機能・形態学概論
Shinshu University

疾患予防医科学
Shinshu University

生化学
Shinshu University

人間機能・形態学概論
Shinshu University

疾患予防医科学
Shinshu University

生化学
Shinshu University

人間機能・形態学概論
Shinshu University

疾患予防医化学概論
Shinshu University

Biochemistry
Shinshu University

Biochemistry
Shinshu University

Biochemistry
Shinshu University

Biochemistry
Shinshu University

Biochemistry
Shinshu University

Biochemistry
Shinshu University

日本糖尿病学会

日本医学教育学会

Japanese Society of Gastroenterology

Japan Society of Hepatology

Japan Society of Metabolism and Clinical Nutrition

The Japanese Biochemical Society

Japanese Society of Internal Medicine

食事中トランス脂肪酸による肝発癌促進機能の解明と予防法の開発
科学研究費補助金, 基盤研究（Ｃ）
2019 - 2021

生体異物代謝を機軸とした非アルコール性脂肪肝炎発症機構の解明
科学研究費補助金, 基盤研究（Ｃ）
2016 - 2018

PPARα 活性化抑制を標的としたＣ型肝炎関連肝癌の予防法の開発
科学研究費補助金, 若手研究（Ｂ）
2009 - 2010

PPARα ノックアウトマウスを用いたアルコール性肝障害の病態解析と治療法の開発
科学研究費補助金, 若手研究（Ｂ）
2007 - 2008

消化管および肝臓におけるアルコール依存的炎症性障害の分子機構の解明と予防法の開発
科学研究費補助金, 基盤研究（Ｃ）
2007 - 2008

共同研究, 米国国立衛生研究所　癌研究所　代謝部門
2004

Functional foods for preventing obesity and fatty liver

Hepatocarcinogenesis caused by hepatic steatosis/steatohepatitis

Pathogenesis of nonalcoholic steatohepatitis and development of therapeutic strategies

Global medical research and education

Dietary Nutrients and Gastrointestinal Disease

Lipid metabolism and nuclear receptor

Liver-adipose interaction

Metabolomics

本当は怖～い脂肪肝
信毎メディアガーデン, 29 Jul. 2018

食生活と生活習慣病
lecturer
信州ソルガム高度活用研究プロジェクトキックオフシンポジウム, 信州大学工学部, 20 Jun. 2017

食生活と生活習慣病
信州大学工学部, 20 Jun. 2017

内臓肥満と糖尿病・高血圧-健診データのみかた–
平成27年度生坂村ヘルスアップ教室, 生坂村, 22 Jan. 2017

本当はこわい脂肪肝～小児から大人まで～
安曇野市, 03 Jul. 2016

NAFLD/NASHの病態・診断と今後の展望
lecturer
第34回日本消化器病学会甲信越支部教育講演会, 信州大学, 2015

健康ばんざい　肝疾患
長野放送, 24 Apr. 2021

こんにちはドクター『本当にこわい脂肪肝』
SBCラジオ, 26 Mar. 2017, Media report

奥様はホームドクター『本当はこわい脂肪肝』
テレビ信州, 06 Mar. 2017, Media report

2020, 1, 1, 5, 4, 2, 2

2019, 2, 2, 5, 4, 1, 1

2006, 1, 1, 1, 1

2021, 5, 4, 0, 0

2010, 5, 1, 5, 1

2009, 1, 0, 1, 0

2008, 2, 0, 2, 0

2012, 1, 0, 1, 0

2014, 2, 0, 2, 0

2018, 1, 1

2016, 2, 2

2019, 2, 0

2017, 2, 2

2020, 1, 0, 2人入学希望、COVID-19 のため1人は入学後休学、もう一人は入試を受験できず。

2017
信州大学医学部顕彰　短期留学, 米国国立衛生研究所

2016
国際交流, ドイツ　ドレスデン工科大学

2016
国際交流, インドネシア