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TANAKA Naoki|Shinshu University Researcher List

TANAKA Naoki

Academic Assembly School of Medicine and Health Sciences Institute of Medicine

School of Medicine Department of Medicine 

Professor 

Degree

  • MD., Ph. D, Shinshu University Graduate School of Medicine

Research Keyword

    NASH, NASH, Nuclear receptor, PPAR, Metabolic syndrome, Adipocyte, Hepatology, Metabolic syndrome, Obesity, Toxicology

Field Of Study

  • Gastroenterology, Hepatology
  • Tertiary education, Global Medical Research
  • Physiology, Nutrition
  • Metabolism and endocrinology, Obesity, Diabetes, Fatty liver and Steatohepatitis
  • Pathological biochemistry, Medical Biochemistry
  • Gastroenterology, Gastroenterology

TEL

    +81-263-37-2354

Career

  • 2022
    Shinshu University Graduate School of Medicine, Department of Global Medical Research Promotion, Professor
  • 2021
    Shinshu University School of Medicine, International Relations Office, Professor
  • 2014
    Associate Professor, Department of Metabolic Regulation, Shinshu University Graduate School of Medicine
  • 2009 - 2012
    Assistant Professor, Department of Metabolic Regulation, Shinshu University Graduate School of Medicine
  • 2006 - 2009
    Assistant Professor, Department of Metabolic Regulation, Shinshu University Graduate School of Medicine
  • 2005 - 2006
    Medical Staff in Gastroenterology, Shinshu University Hospital
  • 2003 - 2005
    Medical Staff in Internal Medicine, Showa Inan General Hospital
  • 2002 - 2003
    Medical Staff in Gastroenterology, Shinshu University Hospital
  • 1995 - 1996
    Resident in Internal Medicine, Shinshu University Hospital

Educational Background

  • 2009 - 2014, Visiting fellow, Laboratory of Metabolism, National Cancer Institute, National Institutes of Health
  • 2002, Shinshu University Graduate School of Medicine, Department of Metabolic Regulation
  • 1995, Shinshu University

Member History

  • 評議員, 日本消化器病学会
  • 評議員, 日本肝臓学会
  • 評議員、NSTコーディネーター, 日本病態栄養学会

Award

  • 2020
    第23回日本病態栄養学会年次学術集会 若手研究会長賞
    Japan
    第23回日本病態栄養学会年次学術集会 若手研究会長賞
  • 2015
    米国国立衛生研究所, The Fellows Award for Research Excellence in NIH
    The Fellows Award for Research Excellence in NIH
  • 2014
    米国国立衛生研究所, The Fellows Award for Research Excellence in NIH
    The Fellows Award for Research Excellence in NIH
  • 2013
    米国国立衛生研究所, The Fellows Award for Research Excellence in NIH
    The Fellows Award for Research Excellence in NIH
  • 2010
    第23回日本消化器病学会奨励賞
    Japan
    第23回日本消化器病学会奨励賞
  • 2009
    信州大学医学部松医会賞基礎分野
    Japan
    信州大学医学部松医会賞基礎分野
  • 2008
    日本肝臓学会第7回Schering-Plough Award基礎分野優秀賞
    Japan
    日本肝臓学会第7回Schering-Plough Award基礎分野優秀賞
  • 2007
    ウイルス肝炎研究財団 研究助成
    ウイルス肝炎研究財団 研究助成

Paper

  • Prognostic Significance of Bile Duct Loss in Early-Stage Primary Biliary Cholangitis: A Long-Term Observational Study.
    Taiki Okumura; Takefumi Kimura; Takanobu Iwadare; Shun-Ichi Wakabayashi; Hiroyuki Kobayashi; Yuki Yamashita; Satoru Joshita; Michiharu Komatsu; Naoki Tanaka; Akihiro Matsumoto; Tomoyuki Nakajima; Mai Iwaya; Masahiro Umemura; Kazuhito Kawata; Kenichi Harada; Takeji Umemura
    Hepatology research : the official journal of the Japan Society of Hepatology, Aug. 2025, Refereedリポジトリ電子ジャーナル
  • Multi-omics analysis of diabetic cardiomyopathy pathogenesis using a type 2 diabetic Zucker diabetic fatty rat model.
    Kazuhiro Tanabe; Qianqian Zheng; Xuguang Zhang; Naoki Tanaka; Chihiro Hayashi; Asaka Yokota; Rina Otsuka; Tomoko Katahira; Motoyuki Kohjima; Makoto Nakamuta
    Scientific reports, 15(1), 22797-22797, Jul. 2025, Refereedリポジトリ電子ジャーナル
  • Thrombospondin 2 as a Predictive Biomarker for HCC in Hepatitis C Patients: A Longitudinal Study Following DAA Therapy.
    Takanobu Iwadare; Takefumi Kimura; Ayumi Sugiura; Taiki Okumura; Shun-Ichi Wakabayashi; Hiroyuki Kobayashi; Yuki Yamashita; Tomoo Yamazaki; Satoru Joshita; Naoki Tanaka; Takeji Umemura
    Journal of viral hepatitis, 32(4), e14025, Apr. 2025, Refereedリポジトリ電子ジャーナル
  • AI-Based Platelet-Independent Noninvasive Test for Liver Fibrosis in MASLD Patients.
    Shun-Ichi Wakabayashi; Takefumi Kimura; Nobuharu Tamaki; Takanobu Iwadare; Taiki Okumura; Hiroyuki Kobayashi; Yuki Yamashita; Naoki Tanaka; Masayuki Kurosaki; Takeji Umemura
    JGH open : an open access journal of gastroenterology and hepatology, 9(4), e70150, Apr. 2025, Refereedリポジトリ電子ジャーナル
  • Dietary Polyunsaturated Fatty Acid Deficiency Impairs Renal Lipid Metabolism and Adaptive Response to Proteinuria in Murine Renal Tubules.
    Yaping Wang; Pan Diao; Daiki Aomura; Takayuki Nimura; Makoto Harada; Fangping Jia; Takero Nakajima; Naoki Tanaka; Yuji Kamijo
    Nutrients, 17(6), Mar. 2025, Refereedリポジトリ電子ジャーナル
  • Colorectal Cancer Incidence in Steatotic Liver Disease (MASLD, MetALD, and ALD).
    Takefumi Kimura; Nobuharu Tamaki; Shun-Ichi Wakabayashi; Naoki Tanaka; Takeji Umemura; Namiki Izumi; Rohit Loomba; Masayuki Kurosaki
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, Jan. 2025, Refereedリポジトリ電子ジャーナル
  • Potential of serum sulfatide levels as a marker for classification and disease activity in lupus nephritis.
    Kosuke Yamaka; Daiki Aomura; Makoto Harada; Takero Nakajima; Takayuki Nimura; Koji Hashimoto; Naoki Tanaka; Yuji Kamijo
    Frontiers in immunology, 16, 1571147-1571147, 2025, Refereedリポジトリ電子ジャーナル
  • Comparison of Free Flavonoids and the Polyphenol Content in the Bran of a Newly Developed Sorghum Variety and Two Commercially Available Sorghum Varieties.
    Mariely Cristine Dos Santos; Naoki Tanaka; Shigemitsu Kasuga; Kazuhiro Tanabe; Chihiro Hayashi; Masahiro Mizuno; Yoshihiko Amano
    Metabolites, 14(11), Nov. 2024, Refereedリポジトリ電子ジャーナル
  • Circulating thrombospondin 2 as a predictor of hepatocellular carcinoma in hepatitis B patients undergoing nucleos(t)ide analog therapy.
    Taiki Okumura; Takefumi Kimura; Yuki Ichikawa; Takanobu Iwadare; Shun-Ichi Wakabayashi; Hiroyuki Kobayashi; Yuki Yamashita; Takuro Uchida; Sai P Pydi; Naoki Tanaka; Takeji Umemura
    Scientific reports, 14(1), 25584-25584, Oct. 2024, Refereedリポジトリ電子ジャーナル
  • Serum autotaxin is a prognostic indicator of liver-related events in patients with non-alcoholic fatty liver disease.
    Takanobu Iwadare; Takefumi Kimura; Taiki Okumura; Shun-Ichi Wakabayashi; Taro Nakajima; Shohei Kondo; Hiroyuki Kobayashi; Yuki Yamashita; Ayumi Sugiura; Naoyuki Fujimori; Tomoo Yamazaki; Hideo Kunimoto; Satoshi Shimamoto; Koji Igarashi; Satoru Joshita; Naoki Tanaka; Takeji Umemura
    Communications medicine, 4(1), 73-73, Apr. 2024, Refereedリポジトリ電子ジャーナル
  • Predictive Insights Into Exocrine Pancreatic Insufficiency in Chronic Pancreatitis and Autoimmune Pancreatitis: A Decision Tree Approach.
    Tomoyuki Tanaka; Takefumi Kimura; Shun-Ichi Wakabayashi; Takuma Okamura; Shohei Shigeto; Naoki Tanaka; Shohei Kondo; Ichitaro Horiuchi; Yasuhiro Kuraishi; Akira Nakamura; Norihiro Ashihara; Keita Kanai; Tadanobu Nagaya; Takayuki Watanabe; Takeji Umemura
    Pancreas, 53(3), e227-e232, Mar. 2024, Refereedリポジトリ電子ジャーナル
  • Thrombospondin 2 is a key determinant of fibrogenesis in non-alcoholic fatty liver disease.
    Takefumi Kimura; Takanobu Iwadare; Shun-Ichi Wakabayashi; Seema Kuldeep; Tomoyuki Nakajima; Tomoo Yamazaki; Daiki Aomura; Hamim Zafar; Mai Iwaya; Satoru Joshita; Takeshi Uehara; Sai P Pydi; Naoki Tanaka; Takeji Umemura
    Liver international : official journal of the International Association for the Study of the Liver, 44(2), 483-496, Feb. 2024, Refereedリポジトリ電子ジャーナル
  • Investigation of Clinical Features and Association between Vascular Endothelial Injury Markers and Cytomegalovirus Infection Associated with Thrombotic Microangiopathy in Patients with Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis: Case-Based Research.
    Takayuki Nimura; Daiki Aomura; Makoto Harada; Akinori Yamaguchi; Kosuke Yamaka; Takero Nakajima; Naoki Tanaka; Takashi Ehara; Koji Hashimoto; Yuji Kamijo
    International journal of molecular sciences, 25(2), Jan. 2024, Refereedリポジトリ電子ジャーナル
  • Long-Term pemafibrate treatment exhibits limited impact on body fat mass in patients with hypertriglyceridemia accompanying NAFLD.
    Takanobu Iwadare; Takefumi Kimura; Hideo Kunimoto; Taiki Okumura; Shun-Ichi Wakabayashi; Hiroyuki Kobayashi; Yuki Yamashita; Ayumi Sugiura; Naoki Tanaka; Takeji Umemura
    Frontiers in endocrinology, 15, 1329294-1329294, 2024, Refereedリポジトリ電子ジャーナル
  • An orally deliverable ornithine-based self-assembling polymer nanomedicine ameliorates hyperammonemia in acetaminophen-induced acute liver injury.
    Yuanyuan Ding; Yuta Koda; Babita Shashni; Naoki Takeda; Xuguang Zhang; Naoki Tanaka; Yuji Nishikawa; Yukio Nagasaki
    Acta biomaterialia, 168, 515-528, Sep. 2023, Refereedリポジトリ電子ジャーナル
  • Establishment of Novel Mouse Model of Dietary NASH Rapidly Progressing into Liver Cirrhosis and Tumors.
    Qianqian Zheng; Masaya Kawaguchi; Hayato Mikami; Pan Diao; Xuguang Zhang; Zhe Zhang; Takero Nakajima; Takanobu Iwadare; Takefumi Kimura; Jun Nakayama; Naoki Tanaka
    Cancers, 15(14), Jul. 2023, Refereed
    Last, Correspondingリポジトリ電子ジャーナル
  • Function and Regulation of the Multifunctional Molecules Sulfated Glycolipids
    NAKAJIMA, Takero; TANAKA, Naoki
    The Shinshu Medical Journal, 71(3), 137-147, Jun. 2023, Refereedリポジトリ電子ジャーナル
  • Citrin Deficiency: Clinical and Nutritional Features.
    Michiharu Komatsu; Naoki Tanaka; Takefumi Kimura; Masahide Yazaki
    Nutrients, 15(10), May 2023, Refereed
    Correspondingリポジトリ電子ジャーナル
  • Resmetirom Ameliorates NASH-Model Mice by Suppressing STAT3 and NF-κB Signaling Pathways in an RGS5-Dependent Manner.
    Xiaojing Wang; Liangjing Wang; Lin Geng; Naoki Tanaka; Bin Ye
    International journal of molecular sciences, 24(6), Mar. 2023, Refereed
    Correspondingリポジトリ電子ジャーナル
  • Dietary Fat Composition Affects Hepatic Angiogenesis and Lymphangiogenesis in Hepatitis C Virus Core Gene Transgenic Mice.
    Pan Diao; Yaping Wang; Fangping Jia; Xiaojing Wang; Xiao Hu; Takefumi Kimura; Yoshiko Sato; Kyoji Moriya; Kazuhiko Koike; Jun Nakayama; Naoki Tanaka
    Liver cancer, 12(1), 57-71, Feb. 2023, Refereed
    Last, Correspondingリポジトリ電子ジャーナル
  • Development of the Rabbit NASH Model Resembling Human NASH and Atherosclerosis.
    Momoko Hayashi; Yoshibumi Kuwabara; Kuniji Ito; Yoshiaki Hojo; Fumiaki Arai; Kazuki Kamijima; Masakazu Takeiri; Xiaojing Wang; Pan Diao; Jun Nakayama; Naoki Tanaka
    Biomedicines, 11(2), Jan. 2023, Refereed
    Last, Correspondingリポジトリ電子ジャーナル
  • PPARα activator irbesartan suppresses the proliferation of endometrial carcinoma cells via SREBP1 and ARID1A.
    Y U Lu; Tsutomu Miyamoto; Hodaka Takeuchi; Fumi Tsunoda; Naoki Tanaka; Tanri Shiozawa
    Oncology research, 31(3), 239-253, 2023, Refereedリポジトリ電子ジャーナル
  • Serum sulfatide level is associated with severe systemic vasculitis with kidney involvement.
    Daiki Aomura; Makoto Harada; Takero Nakajima; Takayuki Nimura; Kosuke Yamaka; Yosuke Yamada; Koji Hashimoto; Naoki Tanaka; Yuji Kamijo
    Frontiers in immunology, 14, 1271741-1271741, 2023, Refereedリポジトリ電子ジャーナル
  • Circulating thrombospondin 2 levels reflect fibrosis severity and disease activity in HCV-infected patients.
    Takanobu Iwadare; Takefumi Kimura; Naoki Tanaka; Tomoo Yamazaki; Shun-Ichi Wakabayashi; Taiki Okumura; Hiroyuki Kobayashi; Yuki Yamashita; Sai P Pydi; Tomoyuki Nakajima; Mai Iwaya; Ayumi Sugiura; Satoru Joshita; Takeshi Uehara; Takeji Umemura
    Scientific reports, 12(1), 18900-18900, Nov. 2022, Refereedリポジトリ電子ジャーナル
  • Higher Responsiveness for Women, High Transaminase Levels, and Fat Percentage to Pemafibrate Treatment for NAFLD.
    Takanobu Iwadare; Takefumi Kimura; Hideo Kunimoto; Naoki Tanaka; Shun-Ichi Wakabayashi; Tomoo Yamazaki; Taiki Okumura; Hiroyuki Kobayashi; Yuki Yamashita; Ayumi Sugiura; Satoru Joshita; Takeji Umemura
    Biomedicines, 10(11), Nov. 2022, Refereedリポジトリ電子ジャーナル
  • Clinically Relevant Dose of Pemafibrate, a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα), Lowers Serum Triglyceride Levels by Targeting Hepatic PPARα in Mice.
    Zhe Zhang; Pan Diao; Xuguang Zhang; Takero Nakajima; Takefumi Kimura; Naoki Tanaka
    Biomedicines, 10(7), Jul. 2022, Refereed
    Last, Correspondingリポジトリ電子ジャーナル
  • Pemafibrate for primary biliary cholangitis with dyslipidemia: A proposal of a new treatment from Japan.
    Naoki Tanaka; Akira Honda
    Hepatology research : the official journal of the Japan Society of Hepatology, 52(6), 495-496, Jun. 2022, Refereed
    Lead, Correspondingリポジトリ電子ジャーナル
  • Managing bleeding risk after cold snare polypectomy in patients receiving direct-acting oral anticoagulants.
    Atsushi Morita; Ichitaro Horiuchi; Naoki Tanaka; Hidetoshi Takada; David Y Graham; Akira Horiuchi
    Gastrointestinal endoscopy, 95(5), 969-974, May 2022, Refereedリポジトリ電子ジャーナル
  • 2-Step PLT16-AST44 method: Simplified liver fibrosis detection system in patients with non-alcoholic fatty liver disease
    Fujimori, Naoyuki; Kimura, Takefumi; Tanaka, Naoki; Yamazaki, Tomoo; Okumura, Taiki; Kobayashi, Hiroyuki; Wakabayashi, Shun-Ichi; Yamashita, Yuki; Sugiura, Ayumi; Pham, Jonathan; Pydi, Sai P.; Sano, Kenji; Joshita, Satoru; Umemura, Takeji
    HEPATOLOGY RESEARCH, 52(4), 352-363, Apr. 2022, Refereedリポジトリ電子ジャーナル
  • Serum Sulfatide Levels as a Biomarker of Active Glomerular Lesion in Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Single Center Pilot Study
    Harada, Makoto; Nakajima, Takero; Yamada, Yosuke; Aomura, Daiki; Yamaguchi, Akinori; Sonoda, Kosuke; Tanaka, Naoki; Hashimoto, Koji; Kamijo, Yuji
    JOURNAL OF CLINICAL MEDICINE, 11(3), 762, Feb. 2022, Refereedリポジトリ電子ジャーナル
  • Short-term intensive gastrointestinal endoscopy training program.
    Atsushi Morita; Takahiro Kudo; Akira Horiuchi; Masashi Kajiyama; Naoki Tanaka; Hidetoshi Takada
    Pediatrics international : official journal of the Japan Pediatric Society, 64(1), e14721, Jan. 2022, Refereedリポジトリ電子ジャーナル
  • Acidic Activated Charcoal Prevents Obesity and Insulin Resistance in High-Fat Diet-Fed Mice.
    Xuguang Zhang; Pan Diao; Hiroaki Yokoyama; Yoshiki Inoue; Kazuhiro Tanabe; Xiaojing Wang; Chihiro Hayashi; Tomoki Yokoyama; Zhe Zhang; Xiao Hu; Takero Nakajima; Takefumi Kimura; Jun Nakayama; Makoto Nakamuta; Naoki Tanaka
    Frontiers in nutrition, 9, 852767-852767, 2022, Refereed
    Last, Correspondingリポジトリ電子ジャーナル
  • Mechanisms of Steatosis-Derived Hepatocarcinogenesis: Lessons from HCV Core Gene Transgenic Mice
    Diao, Pan; Jia, Fangping; Wang, Xiaojing; Hu, Xiao; Kimura, Takefumi; Nakajima, Takero; Aoyama, Toshifumi; Moriya, Kyoji; Koike, Kazuhiko; Tanaka, Naoki
    ENGINEERING, 7(12), 1797-1805, Dec. 2021, Refereed
    Last, Correspondingリポジトリ電子ジャーナル
  • Mucosal defect size predicts the adequacy of resection of <= 10 mm nonpedunculated colorectal polyps using a new cold snare polypectomy technique
    Kudo, Takahiro; Horiuchi, Akira; Kyodo, Reiko; Tokita, Kazuhide; Tanaka, Naoki; Horiuchi, Ichitaro; Sano, Kenji
    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 33, E484-E489, Dec. 2021, Refereedリポジトリ電子ジャーナル
  • Impact of Dietary Fat on the Progression of Liver Fibrosis: Lessons from Animal and Cell Studies
    Jia, Fangping; Hu, Xiao; Kimura, Takefumi; Tanaka, Naoki
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(19), 10303, Oct. 2021, Refereed
    Last, Correspondingリポジトリ電子ジャーナル
  • Pemafibrate, a novel selective PPARα modulator, attenuates tamoxifen-induced fatty liver disease.
    Naoki Tanaka; Kazutaka Mukaiyama; Akio Morikawa; Satoshi Kawakami; Yasuyuki Ichise; Takefumi Kimura; Akira Horiuchi
    Clinical journal of gastroenterology, 14(3), 846-851, Jun. 2021, Refereed
    Lead, Correspondingリポジトリ電子ジャーナル
  • Linked colour imaging versus white-light colonoscopy for the detection of flat colorectal lesions: A randomized controlled trial
    Kudo, Takahiro; Horiuchi, Akira; Kyodo, Reiko; Horiuchi, Ichitaro; Arai, Nobuyasu; Kajiyama, Masashi; Tanaka, Naoki
    COLORECTAL DISEASE, 23(6), 1414-1420, Jun. 2021, Refereed
    Lastリポジトリ電子ジャーナル
  • Pemafibrate Protects against Fatty Acid-Induced Nephropathy by Maintaining Renal Fatty Acid Metabolism
    Aomura, Daiki; Harada, Makoto; Yamada, Yosuke; Nakajima, Takero; Hashimoto, Koji; Tanaka, Naoki; Kamijo, Yuji
    METABOLITES, 11(6), 372, Jun. 2021, Refereedリポジトリ電子ジャーナル
  • Risk of Gastrointestinal Endoscopic Procedure-Related Bleeding in Patients With or Without Continued Antithrombotic Therapy.
    Kiyoaki Yabe; Akira Horiuchi; Takahiro Kudo; Ichitaro Horiuchi; Yasuyuki Ichise; Masashi Kajiyama; Naoki Tanaka
    Digestive diseases and sciences, 66(5), 1548-1555, May 2021, Refereedリポジトリ電子ジャーナル
  • Serum thrombospondin 2 is a novel predictor for the severity in the patients with NAFLD
    Kimura, Takefumi; Tanaka, Naoki; Fujimori, Naoyuki; Yamazaki, Tomoo; Katsuyama, Takahito; Iwashita, Yuichi; Pham, Jonathan; Joshita, Satoru; Pydi, Sai P.; Umemura, Takeji
    LIVER INTERNATIONAL, 41(3), 505-514, Mar. 2021, Refereedリポジトリ電子ジャーナル
  • Role of G Protein-Coupled Receptors in Hepatic Stellate Cells and Approaches to Anti-Fibrotic Treatment of Non-Alcoholic Fatty Liver Disease
    Kimura, Takefumi; Singh, Simran; Tanaka, Naoki; Umemura, Takeji
    FRONTIERS IN ENDOCRINOLOGY, 12, 773432-773432, 2021, Refereed
    Correspondingリポジトリ電子ジャーナル
  • A saturated fatty acid-rich diet enhances hepatic lipogenesis and tumorigenesis in HCV core gene transgenic mice
    Diao, Pan; Wang, Xiaojing; Jia, Fangping; Kimura, Takefumi; Hu, Xiao; Shirotori, Saki; Nakamura, Ibuki; Sato, Yoshiko; Nakayama, Jun; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Aoyama, Toshifumi; Tanaka, Naoki
    JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 85, Nov. 2020, Refereed
    Last, Correspondingリポジトリ電子ジャーナル
  • Invasive liver abscess syndrome accompanied by spondylodiscitis: a case report and review of the literature
    Wakabayashi SI, Kimura T, Tanaka N, Pham J, Tanaka T, Higuchi S, Kobayashi J, Umemura T, Iijima A.
    Clin J Gastroenterol, 13(5), 927-934, Oct. 2020, Refereed
  • Metabolic Functions of G Protein-Coupled Receptors in Hepatocytes-Potential Applications for Diabetes and NAFLD
    Kimura, Takefumi; Pydi, Sai P.; Pham, Jonathan; Tanaka, Naoki
    BIOMOLECULES, 10(10), Oct. 2020, Refereed
    Lastリポジトリ電子ジャーナル
  • Non-alcoholic fatty liver disease later diagnosed as myotonic dystrophy
    Tanaka N, Kimura T, Fujimori N, Ichise Y, Sano K, Horiuchi A.
    World J Hepatol. 2020 Sep 27;12(9):685-692. doi: 10.4254/wjh.v12.i9.685., 12(9), 685-692, Sep. 2020, Refereed
    Lead, Correspondingリポジトリ電子ジャーナル
  • Acute liver failure with severe steatosis induced by mushroom
    Wakabayashi, Shun-ichi; Kimura, Takefumi; Tanaka, Naoki
    LIVER INTERNATIONAL, 40(9), 2291-2292, Sep. 2020, Refereed
    Lastリポジトリ電子ジャーナル
  • Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice
    Jia, Fangping; Diao, Pan; Wang, Xiaojing; Hu, Xiao; Kimura, Takefumi; Nakamuta, Makoto; Nakamura, Ibuki; Shirotori, Saki; Sato, Yoshiko; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Nakayama, Jun; Aoyama, Toshifumi; Tanaka, Naoki
    LIVER CANCER, 9(5), 529-548, Sep. 2020, Refereed
    Last, Correspondingリポジトリ電子ジャーナル
  • Polyunsaturated fatty acid deficiency affects sulfatides and other sulfated glycans in lysosomes through autophagy-mediated degradation
    Wang, Yaping; Nakajima, Takero; Diao, Pan; Yamada, Yosuke; Nakamura, Kozo; Nakayama, Jun; Tanaka, Naoki; Aoyama, Toshifumi; Kamijo, Yuji
    FASEB JOURNAL, 34(7), 9594-9614, Jul. 2020, Refereedリポジトリ電子ジャーナル
  • Congestive hepatopathy and acute pancreatitis as severe complications of mixed connective tissue disease
    Kurihara S, Kimura T, Tanaka N, Yanagisawa T, Kobayashi H, Kanai K, Umemura T, Kobayashi M, Mori H, Wada S.
    Clin J Gastroenterol, 13(3), 434-442, Jun. 2020, Refereed
  • PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice
    Wang, Yaping; Nakajima, Takero; Gonzalez, Frank J.; Tanaka, Naoki
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(6), -, Mar. 2020, Refereed
    Last, Correspondingリポジトリ電子ジャーナル
  • Long-term luseogliflozin therapy improves histological activity of non-alcoholic steatohepatitis accompanied by type 2 diabetes mellitus
    Fujimori N, Tanaka N, Kimura T, Sano K, Horiuchi A, Kato N, Takahashi Y, Kuribayashi N, Sugiura A, Yamazaki T, Joshita S, Umemura T, Matsumoto A, Tanaka E.
    Clin J Gastroenterol, 13(1), 83-89, Feb. 2020, Refereed
    Correspondingリポジトリ電子ジャーナル
  • A trans-fatty acid-rich diet promotes liver tumorigenesis in HCV core gene transgenic mice
    Hu, Xiao; Wang, Xiaojing; Jia, Fangping; Tanaka, Naoki; Kimura, Takefumi; Nakajima, Takero; Sato, Yoshiko; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Nakayama, Jun; Aoyama, Toshifumi
    CARCINOGENESIS, 41(2), 159-170, Feb. 2020, Refereed
    Correspondingリポジトリ電子ジャーナル
  • Cold snare polypectomy: Indications, devices, techniques, outcomes and future
    Horiuchi, Akira; Ikuse, Tamaki; Tanaka, Naoki
    DIGESTIVE ENDOSCOPY, 31(4), 372-377, Jul. 2019, Refereed
    Lastリポジトリ電子ジャーナル
  • What will happen in patients with advanced nonalcoholic fatty liver disease?
    Takefumi Kimura; Naoki Tanaka; Eiji Tanaka
    Hepatobiliary surgery and nutrition, 8(3), 283-285, Jun. 2019リポジトリ電子ジャーナル
  • A high-cholesterol diet promotes steatohepatitis and liver tumorigenesis in HCV core gene transgenic mice
    Wang, Xiaojing; Tanaka, Naoki; Hu, Xiao; Kimura, Takefumi; Lu, Yu; Jia, Fangping; Sato, Yoshiko; Nakayama, Jun; Moriya, Kyoji; Koike, Kazuhiko; Aoyama, Toshifumi
    ARCHIVES OF TOXICOLOGY, 93(6), 1713-1725, Jun. 2019, Refereed
    Correspondingリポジトリ電子ジャーナル
  • Lipidomics reveal aryl hydrocarbon receptor (Ahr)-regulated lipid metabolic pathway in alpha-naphthyl isothiocyanate (ANIT)-induced intrahepatic cholestasis.
    Bao-Long Wang; Chang-Wen Zhang; Liang Wang; Kun-Long Tang; Naoki Tanaka; Frank J Gonzalez; Yong Xu; Zhong-Ze Fang
    Xenobiotica; the fate of foreign compounds in biological systems, 49(5), 591-601, May 2019リポジトリ電子ジャーナル
  • Safety and Effectiveness of Nurse-Administered Propofol Sedation in Outpatients Undergoing Gastrointestinal Endoscopy
    Sato, Masamichi; Horiuchi, Akira; Tamaki, Michio; Ichise, Yasuyuki; Kajiyama, Masashi; Yamamoto, Yuta; Tanaka, Naoki
    CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 17(6), 1098-+, May 2019, Refereed
    Lastリポジトリ電子ジャーナル
  • Red plasma and ascites under ultraviolet A
    Wakabayashi, Shun-ichi; Kimura, Takefumi; Tanaka, Naoki; Komatsu, Michiharu; Tanaka, Eiji
    LANCET GASTROENTEROLOGY & HEPATOLOGY, 4(4), 324-324, Apr. 2019, Refereed
  • Peroxisome proliferator-activated receptor attenuates high-cholesterol diet-induced toxicity and pro-thrombotic effects in mice
    Lu, Yu; Harada, Makoto; Kamijo, Yuji; Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Kyogashima, Mamoru; Gonzalez, Frank J.; Aoyama, Toshifumi
    ARCHIVES OF TOXICOLOGY, 93(1), 149-161, Jan. 2019, Refereed, Not invitedリポジトリ電子ジャーナル
  • Gastric Emptying of Elemental Liquid Diets Versus Semisolid Diets in Bedridden Gastrostomy-fed Patients
    Horiuchi, Akira; Sakai, Ryosei; Tamaki, Michio; Kajiyama, Masashi; Tanaka, Naoki; Morikawa, Akio
    JOURNAL OF CLINICAL GASTROENTEROLOGY, 53(5), 373-378, 2019, Refereedリポジトリ電子ジャーナル
  • Current status, problems, and perspectives of non-alcoholic fatty liver disease research
    Tanaka, Naoki; Kimura, Takefumi; Fujimori, Naoyuki; Nagaya, Tadanobu; Komatsu, Michiharu; Tanaka, Eiji
    WORLD JOURNAL OF GASTROENTEROLOGY, 25(2), 163-177, 2019, Refereed, Not invited
    Lead, Correspondingリポジトリ電子ジャーナル
  • Miglitol attenuates non-alcoholic steatohepatitis in diabetic patients
    Komatsu, Michiharu; Tanaka, Naoki; Kimura, Takefumi; Fujimori, Naoyuki; Sano, Kenji; Horiuchi, Akira; Sugiura, Ayumi; Yamazaki, Tomoo; Shibata, Soichiro; Joshita, Satoru; Umemura, Takeji; Matsumoto, Akihiro; Tanaka, Eiji
    HEPATOLOGY RESEARCH, 48(13), 1092-1098, Dec. 2018, Refereed, Not invited
    Correspondingリポジトリ電子ジャーナル
  • Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development.
    Takahashi S; Tanaka N; Fukami T; Xie C; Yagai T; Kim D; Velenosi TJ; Yan T; Krausz KW; Levi M; Gonzalez FJ
    Hepatol Commun, 2(12), 1567-1582, Oct. 2018, Refereed, Not invited
    Lead
  • Emergence of anti-mitochondrial M2 antibody in patient with angioimmunoblastic T-cell lymphoma.
    Wakabayashi SI; Kimura T; Tanaka N; Joshita S; Kawata K; Umemura T; Hiroshima Y; Mori H; Kobayashi H; Wada S; Tanaka E
    Clin J Gastroenterol, 11(4), 302-308, Aug. 2018, Refereed, Not invitedリポジトリ電子ジャーナル
  • Salmonella Enteritidis cholecystitis with chronic granulomatous disease.
    Yamashita Y; Kimura T; Tanaka N; Yazaki M; Itagaki T; Joshita S; Umemura T; Matsumoto A; Mori H; Wada S; Tanaka E
    IDCases, 12, 12:49-52, May 2018, Refereed, Not invited
  • Mild drinking habit is a risk factor for hepatocarcinogenesis in non-alcoholic fatty liver disease with advanced fbrosis
    Takefumi Kimura; Naoki Tanaka; Naoyuki Fujimori; Ayumi Sugiura; Tomoo Yamazaki; Satoru Joshita; Michiharu Komatsu; Takeji Umemura; Akihiro Matsumoto; Eiji Tanaka
    World Journal of Gastroenterology, 24(13), 1440-1450, Apr. 2018, Refereed, Not invited
    Correspondingリポジトリ電子ジャーナル
  • Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non-alcoholic fatty liver disease
    Naoyuki Fujimori; Takeji Umemura; Takefumi Kimura; Naoki Tanaka; Ayumi Sugiura; Tomoo Yamazaki; Satoru Joshita; Michiharu Komatsu; Yoko Usami; Kenji Sano; Koji Igarashi; Akihiro Matsumoto; Eiji Tanaka
    World Journal of Gastroenterology, 24(11), 1239-1249, Mar. 2018, Refereed, Not invitedリポジトリ電子ジャーナル
  • Hepatic Angiosarcoma with Kasabach-Merritt Phenomenon: A Case Report and Review of the Literature
    Fujii, Fumika; Kimura, Takefumi; Tanaka, Naoki; Kubota, Daisuke; Sugiura, Ayumi; Umemura, Takeji; Wada, Shuichi; Tanaka, Eiji
    ANNALS OF HEPATOLOGY, 17(4), 655-660, 2018, Refereed, Not invitedリポジトリ電子ジャーナル
  • Delayed Bleeding Following Cold Snare Polypectomy for Small Colorectal Polyps in Patients Taking Antithrombotic Agents
    Toshiyuki Makino; Akira Horiuchi; Masashi Kajiyama; Naoki Tanaka; Kenji Sano; Iruru Maetani
    Journal of Clinical Gastroenterology, 52(6), 502-507, 2018, Refereed, Not invitedリポジトリ電子ジャーナル
  • Growth arrest and DNA damage-inducible 45 alpha protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet
    Naoki Tanaka; Shogo Takahashi; Xiao Hu; Yu Lu; Naoyuki Fujimori; Srujana Golla; Zhong-Ze Fang; Toshifumi Aoyama; Kristopher W. Krausz; Frank J. Gonzalez
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1863(12), 3170-3182, Dec. 2017, Refereed, Not invited
    LeadWebofScienceリポジトリ電子ジャーナル
  • Targeting nuclear receptors for the treatment of fatty liver disease
    Naoki Tanaka; Toshifumi Aoyama; Shioko Kimura; Frank J. Gonzalez
    PHARMACOLOGY & THERAPEUTICS, 179, 142-157, Nov. 2017, Refereed, Not invited
    Lead, CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Cimetidine/lactulose therapy ameliorates erythropoietic protoporphyria-related liver injury
    Fujimori N; Komatsu M; Tanaka N; Iwaya M; Nakano H; Sugiura A; Yamazaki T; Shibata S; Iwaya Y; Muraki T; Ichikawa Y; Kimura T; Joshita S; Umemura T; Matsumoto A; Tanaka E
    Clin J Gastroenterol, 10(5), 452-458, Oct. 2017, Refereed, Not invited
    Corresponding
  • Association between lower air pressure and the onset of ischemic colitis: a case-control study
    Takefumi Kimura; Akihiro Shinji; Naoki Tanaka; Masayoshi Koinuma; Maki Yamaura; Tadanobu Nagaya; Satoru Joshita; Michiharu Komatsu; Takeji Umemura; Akira Horiuchi; Shuichi Wada; Eiji Tanaka
    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 29(9), 1071-1078, Sep. 2017, Refereed, Not invited
    CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Farnesoid X Receptor Protects Against Low-Dose Carbon Tetrachloride-Induced Liver Injury Through the Taurocholate-JNK Pathway
    Shogo Takahashi; Naoki Tanaka; Srujana Golla; Tatsuki Fukami; Kristopher W. Krausz; Marianne A. Polunas; Blair C. Weig; Yusuke Masuo; Cen Xie; Changtao Jiang; Frank J. Gonzalez
    TOXICOLOGICAL SCIENCES, 158(2), 334-346, Aug. 2017, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Glycyrrhizin and glycyrrhetinic acid inhibits alpha-naphthyl isothiocyanate-induced liver injury and bile acid cycle disruption
    Haina Wang; Zhong-Ze Fang; Ran Meng; Yun-Feng Cao; Naoki Tanaka; Kristopher W. Krausz; Frank J. Gonzalez
    TOXICOLOGY, 386, 133-142, Jul. 2017, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Decreased Fatty Acid beta-Oxidation Is the Main Cause of Fatty Liver Induced by Polyunsaturated Fatty Acid Deficiency in Mice
    Takero Nakajima; Yang Yang; Yu Lu; Yuji Kamijo; Yosuke Yamada; Kozo Nakamura; Masahiro Koyama; Shohei Yamaguchi; Eiko Sugiyama; Naoki Tanaka; Toshifumi Aoyama
    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 242(3), 229-239, Jul. 2017, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Successful Treatment for Chronic Hepatitis C-Autoimmune Hepatitis Overlap Syndrome due to Daclatasvir and Asunaprevir
    Sugiura A; Wada S; Mori H; Kimura T; Matsuda Y; Tanaka N; Tanaka E; Kiyosawa K
    Case Rep Gastroenterol, 11(2), 305-311, May 2017, Refereed, Not invited
    Corresponding
  • Role of the lipid-regulated NF-kappa B/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury
    Zhong-Ze Fang; Naoki Tanaka; Dan Lu; Chang-Tao Jiang; Wei-Hua Zhang; Chunze Zhang; Zuo Du; Zhi-Wei Fu; Peng Gao; Yun-Feng Cao; Hong-Zhi Sun; Zhi-Tu Zhu; Yan Cai; Kristopher W. Krausz; Zhi Yao; Frank J. Gonzalez
    ARCHIVES OF TOXICOLOGY, 91(5), 2235-2244, May 2017, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Clinicopathological characteristics of non-B non-C hepatocellular carcinoma without past hepatitis B virus infection
    Takefumi Kimura; Akira Kobayashi; Naoki Tanaka; Kenji Sano; Michiharu Komatsu; Naoyuki Fujimori; Tomoo Yamazaki; Soichiro Shibata; Yuki Ichikawa; Satoru Joshita; Takeji Umemura; Akihiro Matsumoto; Akira Horiuchi; Hiromitsu Mori; Shuichi Wada; Kendo Kiyosawa; Shin-ichi Miyagawa; Eiji Tanaka
    HEPATOLOGY RESEARCH, 47(5), 405-418, Apr. 2017, Refereed, Not invited
    CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Development of diffuse large B-cell lymphoma from follicular lymphoma of the duodenum: changes in endoscopic findings during a 6-year follow-up.
    Hiroyuki Kitabatake; Tadanobu Nagaya; Naoki Tanaka; Hiroyoshi Ota; Kenji Sano; Naoko Asano; Tomoaki Suga; Yoshiyuki Nakamura; Taiji Akamatsu; Eiji Tanaka
    Clinical journal of gastroenterology, 10(1), 79-85, Feb. 2017, Refereedリポジトリ電子ジャーナル
  • Massive ascites caused by intra-pancreatic arterioportal fistula: a rare complication of chronic pancreatitis.
    Tomoo Yamazaki; Yasuhide Ochi; Naoki Tanaka; Takayuki Watanabe; Yugo Iwaya; Ayako Seki; Etsuo Hara; Eiji Tanaka; Tomoharu Watanabe; Shun Imai; Osamu Hasebe
    Clinical journal of gastroenterology, 10(1), 73-78, Feb. 2017, Refereed
    Correspondingリポジトリ電子ジャーナル
  • Association between endotoxemia and histological features of nonalcoholic fatty liver disease
    Hiroyuki Kitabatake; Naoki Tanaka; Naoyuki Fujimori; Michiharu Komatsu; Ayaka Okubo; Kyogo Kakegawa; Takefumi Kimura; Ayumi Sugiura; Tomoo Yamazaki; Soichiro Shibata; Yuki Ichikawa; Satoru Joshita; Takeji Umemura; Akihiro Matsumoto; Masayoshi Koinuma; Kenji Sano; Toshifumi Aoyama; Eiji Tanaka
    WORLD JOURNAL OF GASTROENTEROLOGY, 23(4), 712-722, Jan. 2017, Refereed, Not invited
    CorrespondingWebofScienceリポジトリ電子ジャーナル
  • PPAR alpha protects against trans-fatty-acid-containing diet-induced steatohepatitis
    Xiao Hu; Naoki Tanaka; Ran Guo; Yu Lu; Takero Nakajima; Frank J. Gonzalez; Toshifumi Aoyama
    JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 39, 77-85, Jan. 2017, Refereed, Not invited
    CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Vonoprazan-Based Regimen Is More Useful than PPI-Based One as a First-Line Helicobacter pylori Eradication: A Randomized Controlled Trial
    Masafumi Maruyama; Naoki Tanaka; Daisuke Kubota; Masayuki Miyajima; Takefumi Kimura; Koujiro Tokutake; Ryujiro Imai; Toru Fujisawa; Hiromitsu Mori; Yoshiaki Matsuda; Shuichi Wada; Akira Horiuchi; Kendo Kiyosawa
    CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, -, 2017, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • PPAR alpha-dependent cholesterol/testosterone disruption in Leydig cells mediates 2,4-dichlorophenoxyacetic acid-induced testicular toxicity in mice
    Yukiko Harada; Naoki Tanaka; Motoki Ichikawa; Yuji Kamijo; Eiko Sugiyama; Frank J. Gonzalez; Toshifumi Aoyama
    ARCHIVES OF TOXICOLOGY, 90(12), 3061-3071, Dec. 2016, Refereed, Not invited
    Lead, CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Age-dependent PPAR alpha activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene
    Yangyang Tian; Yang Yang; Xiaowei Zhang; Takero Nakajima; Naoki Tanaka; Eiko Sugiyama; Yuji Kamijo; Yu Lu; Kyoji Moriya; Kazuhiko Koike; Frank J. Gonzalez; Toshifumi Aoyama
    GLYCOCONJUGATE JOURNAL, 33(6), 927-936, Dec. 2016, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Activation of PPAR alpha by Fatty Acid Accumulation Enhances Fatty Acid Degradation and Sulfatide Synthesis
    Yang Yang; Yuyao Feng; Xiaowei Zhang; Takero Nakajima; Naoki Tanaka; Eiko Sugiyama; Yuji Kamijo; Toshifumi Aoyama
    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 240(2), 113-122, Oct. 2016, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Controlled attenuation parameter is correlated with actual hepatic fat content in patients with non-alcoholic fatty liver disease with none-to-mild obesity and liver fibrosis
    Naoyuki Fujimori; Naoki Tanaka; Soichiro Shibata; Kenji Sano; Tomoo Yamazaki; Tomohiro Sekiguchi; Hiroyuki Kitabatake; Yuki Ichikawa; Takefumi Kimura; Michiharu Komatsu; Takeji Umemura; Akihiro Matsumoto; Eiji Tanaka
    HEPATOLOGY RESEARCH, 46(10), 1019-1027, Sep. 2016, Refereed, Not invited
    CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Comparison between endoscopic mucosal resection and hot snare resection of large nonpedunculated colorectal polyps: a randomized trial
    Akira Horiuchi; Toshiyuki Makino; Masashi Kajiyama; Naoki Tanaka; Kenji Sano; David Y. Graham
    ENDOSCOPY, 48(7), 646-651, Jul. 2016, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Determination of the cut-off score of an endoscopic scoring method to predict whether elderly patients with dysphagia can eat pureed diets.
    Torao Sakamoto; Akira Horiuchi; Toshiyuki Makino; Masashi Kajiyama; Naoki Tanaka; Masamitsu Hyodo
    World journal of gastrointestinal endoscopy, 8(6), 288-94, Mar. 2016, Refereedリポジトリ電子ジャーナル
  • Irinotecan (CPT-11)-induced elevation of bile acids potentiates suppression of IL-10 expression
    Zhong-Ze Fang; Dunfang Zhang; Yun-Feng Cao; Cen Xie; Dan Lu; Dong-Xue Sun; Naoki Tanaka; Changtao Jiang; Qianming Chen; Yu Chen; Haina Wang; Frank J. Gonzalez
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 291, 21-27, Jan. 2016, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Comparison of newly found polyps after removal of small colorectal polyps with cold or hot snare polypectomy
    Akira Horiuchi; Toshiyuki Makino; Yasuyuki Ichise; Masashi Kajiyama; Naoyuki Kato; Naoki Tanaka
    ACTA GASTRO-ENTEROLOGICA BELGICA, 78(4), 406-410, Oct. 2015, Refereed, Not invited
    LastWebofScienceリポジトリ
  • Prospective, randomized comparison of 2 methods of cold snare polypectomy for small colorectal polyps
    Akira Horiuchi; Kenji Hosoi; Masashi Kajiyama; Naoki Tanaka; Kenji Sano; David Y. Graham
    GASTROINTESTINAL ENDOSCOPY, 82(4), 686-692, Oct. 2015, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans
    Ming-Jiang Xu; Yan Cai; Hua Wang; Jose Altamirano; Binxia Chang; Adeline Bertola; Gemma Odena; Jim Lu; Naoki Tanaka; Kimihiko Matsusue; Tsutomu Matsubara; Partha Mukhopadhyay; Shioko Kimura; Pal Pacher; Frank J. Gonzalez; Ramon Bataller; Bin Gao
    GASTROENTEROLOGY, 149(4), 1030-U367, Oct. 2015, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Metabolic mapping of A(3) adenosine receptor agonist MRS5980
    Zhong-Ze Fang; Dilip K. Tosh; Naoki Tanaka; Haina Wang; Kristopher W. Krausz; Robert O'Connor; Kenneth A. Jacobson; Frank J. Gonzalez
    BIOCHEMICAL PHARMACOLOGY, 97(2), 215-223, Sep. 2015, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling
    Soumen K. Manna; Srujana Golla; Jaya Prakash Golla; Naoki Tanaka; Yan Cai; Shogo Takahashi; Kristopher W. Krausz; Tsutomu Matsubara; Ilia Korboukh; Frank J. Gonzalez
    CANCER PREVENTION RESEARCH, 8(9), 786-795, Sep. 2015, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Primary hepatocellular carcinoma in a patient with neurofibromatosis type I
    Takefumi Kimura; Naoki Tanaka; Takeji Umemura; Eiji Tanaka
    LIVER INTERNATIONAL, 35(8), 2057-2058, Aug. 2015, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation
    Limin Zhang; Robert G. Nichols; Jared Correll; Iain A. Murray; Naoki Tanaka; Philip B. Smith; Troy D. Hubbard; Aswathy Sebastian; Istvan Albert; Emmanuel Hatzakis; Frank J. Gonzalez; Gary H. Perdew; Andrew D. Patterson
    ENVIRONMENTAL HEALTH PERSPECTIVES, 123(7), 679-688, Jul. 2015, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet
    Naoki Tanaka; Shogo Takahashi; Yuan Zhang; Kristopher W. Krausz; Philip B. Smith; Andrew D. Patterson; Frank J. Gonzalez
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1852(7), 1242-1252, Jul. 2015, Refereed, Not invited
    LeadWebofScienceリポジトリ電子ジャーナル
  • Mechanism of the development of nonalcoholic steatohepatitis after pancreaticoduodenectomy.
    Nagaya T; Tanaka N; Kimura T; Kitabatake H; Fujimori N; Komatsu M; Horiuchi A; Yamaura T; Umemura T; Sano K; Gonzalez FJ; Aoyama T; Tanaka E
    BBA Clin, 3, 168-74-74, Feb. 2015, Refereed, Not invited
    Correspondingリポジトリ電子ジャーナル
  • Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease.
    Changtao Jiang; Cen Xie; Fei Li; Limin Zhang; Robert G Nichols; Kristopher W Krausz; Jingwei Cai; Yunpeng Qi; Zhong-Ze Fang; Shogo Takahashi; Naoki Tanaka; Dhimant Desai; Shantu G Amin; Istvan Albert; Andrew D Patterson; Frank J Gonzalez
    The Journal of clinical investigation, 125(1), 386-402, Jan. 2015, Refereedリポジトリ電子ジャーナル
  • Adipocyte-specific Disruption of Fat-specific Protein 27 Causes Hepatosteatosis and Insulin Resistance in High-fat Diet-fed Mice
    Naoki Tanaka; Shogo Takahashi; Tsutomu Matsubara; Changtao Jiang; Wataru Sakamoto; Tatyana Chanturiya; Ruifeng Teng; Oksana Gavrilova; Frank J. Gonzalez
    JOURNAL OF BIOLOGICAL CHEMISTRY, 290(5), 3092-3105, Jan. 2015, Refereed, Not invited
    LeadWebofScienceリポジトリ電子ジャーナル
  • Helicobacter pylori-negative Differentiated Adenocarcinoma of the Stomach
    Tadanobu Nagaya; Naoki Tanaka; Yugo Iwaya; Yoko Jimbo; Toshiharu Tatai; Tetsuya Ito; Ayako Seki; Kenichi Suzawa; Yasuhide Ochi; Etsuo Hara; Manabu Takata; Toshiaki Otsuki; Mai Iwaya; Noriko Hosaka; Norikazu Arakura; Eiji Tanaka; Osamu Hasebe
    INTERNAL MEDICINE, 54(22), 2857-2862, 2015, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Activation of Intestinal Human Pregnane X Receptor Protects against Azoxymethane/Dextran Sulfate Sodium-Induced Colon Cancer
    Jie Cheng; Zhong-Ze Fang; Kenjiro Nagaoka; Minoru Okamoto; Aijuan Qu; Naoki Tanaka; Shioko Kimura; Frank J. Gonzalez
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 351(3), 559-567, Dec. 2014, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-kappa B and STAT3 signaling
    Aiming Liu; Naoki Tanaka; Lu Sun; Bin Guo; Jung-Hwan Kim; Kristopher W. Krausz; Zhongze Fang; Changtao Jiang; Julin Yang; Frank J. Gonzalez
    CHEMICO-BIOLOGICAL INTERACTIONS, 223, 80-86, Nov. 2014, Refereed, Not invited
    LeadWebofScienceリポジトリ電子ジャーナル
  • Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet
    Naoki Tanaka; Shogo Takahashi; Zhong-Ze Fang; Tsutomu Matsubara; Kristopher W. Krausz; Aijuan Qu; Frank J. Gonzalez
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1841(11), 1596-1607, Nov. 2014, Refereed, Not invited
    LeadWebofScienceリポジトリ電子ジャーナル
  • PPAR alpha-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate
    Yunpeng Qi; Changtao Jiang; Naoki Tanaka; Kristopher W. Krausz; Chad N. Brocker; Zhong-Ze Fang; Bryce X. Bredell; Yatrik M. Shah; Frank J. Gonzalez
    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 307(5), G564-G573, Sep. 2014, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Improving quality measures in colonoscopy and its therapeutic intervention
    Akira Horiuchi; Naoki Tanaka
    WORLD JOURNAL OF GASTROENTEROLOGY, 20(36), 13027-13034, Sep. 2014, Refereed, Not invited
    LastWebofScienceリポジトリ電子ジャーナル
  • Biliary stenting as alternative therapy to stone clearance in elderly patients with bile duct stones
    Akira Horiuchi; Masashi Kajiyama; Yasuyuki Ichise; Haruyo Tada; Naoyuki Fujiwara; Naoki Tanaka
    ACTA GASTRO-ENTEROLOGICA BELGICA, 77(3), 297-301, Sep. 2014, Refereed, Not invited
    LastWebofScienceリポジトリ
  • Laparoscopic findings of congenital hepatic fibrosis: A case report and review of the published work
    Michiharu Komatsu; Naoki Tanaka; So-Ichirou Shibata; Takefumi Kimura; Yuki Ichikawa; Susumu Morita; Satoru Joshita; Tadanobu Nagaya; Takeji Umemura; Tetsuya Ichijo; Akihiro Matsumoto; Kaname Yoshizawa; Eiji Tanaka
    HEPATOLOGY RESEARCH, 44(7), 818-824, Jul. 2014, Refereed, Not invited
    CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Herb-drug interaction prediction based on the high specific inhibition of andrographolide derivatives towards UDP-glucuronosyltransferase (UGT) 2B7
    Hai-Ying Ma; Dong-Xue Sun; Yun-Feng Cao; Chun-Zhi Ai; Yan-Qing Qu; Cui-Min Hu; Changtao Jiang; Pei-Pei Dong; Xiao-Yu Sun; Mo Hong; Naoki Tanaka; Frank J. Gonzalez; Xiao-Chi Ma; Zhong-Ze Fang
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 277(1), 86-94, May 2014, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Biomarkers of Coordinate Metabolic Reprogramming in Colorectal Tumors in Mice and Humans
    Soumen K. Manna; Naoki Tanaka; Kristopher W. Krausz; Majda Haznadar; Xiang Xue; Tsutomu Matsubara; Elise D. Bowman; Eric R. Fearon; Curtis C. Harris; Yatrik M. Shah; Frank J. Gonzalez
    GASTROENTEROLOGY, 146(5), 1313-1324, May 2014, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • In vivo effects of the pure aryl hydrocarbon receptor antagonist GNF-351 after oral administration are limited to the gastrointestinal tract
    Zhong-Ze Fang; Kristopher W. Krausz; Kenjiro Nagaoka; Naoki Tanaka; Krishne Gowda; Shantu G. Amin; Gary H. Perdew; Frank J. Gonzalez
    BRITISH JOURNAL OF PHARMACOLOGY, 171(7), 1735-1746, Apr. 2014, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Removal of small colorectal polyps in anticoagulated patients: a prospective randomized comparison of cold snare and conventional polypectomy
    Akira Horiuchi; Yoshiko Nakayama; Masashi Kajiyama; Naoki Tanaka; Kenji Sano; David Y. Graham
    GASTROINTESTINAL ENDOSCOPY, 79(3), 417-423, Mar. 2014, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice
    Jie Cheng; Zhong-Ze Fang; Jung-Hwan Kim; Kristopher W. Krausz; Naoki Tanaka; John Y. L. Chiang; Frank J. Gonzalez
    JOURNAL OF LIPID RESEARCH, 55(3), 455-465, Mar. 2014, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Chronic ethanol consumption decreases serum sulfatide levels by suppressing hepatic cerebroside sulfotransferase expression in mice
    Hiroki Kanbe; Yuji Kamijo; Takero Nakajima; Naoki Tanaka; Eiko Sugiyama; Lixuan Wang; Zhong-Ze Fang; Atsushi Hara; Frank J. Gonzalez; Toshifumi Aoyama
    ARCHIVES OF TOXICOLOGY, 88(2), 367-379, Feb. 2014, Not invited
    CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Role of Myc in hepatocellular proliferation and hepatocarcinogenesis
    Aijuan Qu; Changtao Jiang; Yan Cai; Jung-Hwan Kim; Naoki Tanaka; Jerrold M. Ward; Yatrik M. Shah; Frank J. Gonzalez
    JOURNAL OF HEPATOLOGY, 60(2), 331-338, Feb. 2014, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Steatogenesis in adult-onset type II citrullinemia is associated with down-regulation of PPAR alpha
    Takefumi Kimura
    HEPATOLOGY, 60(3), 819A-819A, 2014, Refereed, Not invited
    CorrespondingWebofScienceリポジトリ電子ジャーナル
  • A model of in vitro UDP-glucuronosyltransferase inhibition by bile acids predicts possible metabolic disorders
    Zhong-Ze Fang; Rong-Rong He; Yun-Feng Cao; Naoki Tanaka; Changtao Jiang; Kristopher W. Krausz; Yunpeng Qi; Pei-Pei Dong; Chun-Zhi Ai; Xiao-Yu Sun; Mo Hong; Guang-Bo Ge; Frank J. Gonzalez; Xiao-Chi Ma; Hong-Zhi Sun
    JOURNAL OF LIPID RESEARCH, 54(12), 3334-3344, Dec. 2013, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum
    Zhong-Ze Fang; Kristopher W. Krausz; Naoki Tanaka; Fei Li; Aijuan Qu; Jeffrey R. Idle; Frank J. Gonzalez
    ARCHIVES OF TOXICOLOGY, 87(11), 1975-1987, Nov. 2013, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Peroxisome proliferator-activated receptor α mediates enhancement of gene expression of cerebroside sulfotransferase in several murine organs
    Takero Nakajima; Yuji Kamijo; Huang Yuzhe; Takefumi Kimura; Naoki Tanaka; Eiko Sugiyama; Kozo Nakamura; Mamoru Kyogashima; Atsushi Hara; Toshifumi Aoyama
    Glycoconjugate Journal, 30(6), 553-560, Aug. 2013, Refereed, Not invitedリポジトリ電子ジャーナル
  • Elemental diets may reduce the risk of aspiration pneumonia in bedridden gastrostomy-fed patients.
    Akira Horiuchi; Yoshiko Nakayama; Ryosei Sakai; Manabu Suzuki; Masashi Kajiyama; Naoki Tanaka
    The American journal of gastroenterology, 108(5), 804-10, May 2013, Refereed
    Lastリポジトリ電子ジャーナル
  • Safety and Effectiveness of Low-Dose Propofol Sedation During and After Esophagogastroduodenoscopy in Child A and B Cirrhotic Patients
    Naoki Tanaka; Akira Horiuchi; Yoshiko Nakayama; Yoshihiko Katsuyama; Masatsugu Isobe; Toshifumi Aoyama; Eiji Tanaka; Shigeru Ohmori
    DIGESTIVE DISEASES AND SCIENCES, 58(5), 1383-1389, May 2013, Refereed, Not invited
    LeadWebofScienceリポジトリ電子ジャーナル
  • Benefits and limitations of cap-fitted colonoscopy in screening colonoscopy.
    Akira Horiuchi; Yoshiko Nakayama; Masashi Kajiyama; Naoyuki Kato; Yasuyuki Ichise; Naoki Tanaka
    Digestive diseases and sciences, 58(2), 534-9, Feb. 2013, Refereed
    Lastリポジトリ電子ジャーナル
  • TGF-beta-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury
    Tsutomu Matsubara; Naoki Tanaka; Misako Sato; Dong Wook Kang; Kristopher W. Krausz; Kathleen C. Flanders; Kazuo Ikeda; Hans Luecke; Lalage M. Wakefield; Frank J. Gonzalez
    JOURNAL OF LIPID RESEARCH, 53(12), 2698-2707, Dec. 2012, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Metabolic map and bioactivation of the anti-tumour drug noscapine.
    Zhong-Ze Fang; Kristopher W Krausz; Fei Li; Jie Cheng; Naoki Tanaka; Frank J Gonzalez
    British journal of pharmacology, 167(6), 1271-86, Nov. 2012, Refereedリポジトリ電子ジャーナル
  • Metabolomics Identifies an Inflammatory Cascade Involved in Dioxin- and Diet-Induced Steatohepatitis
    Tsutomu Matsubara; Naoki Tanaka; Kristopher W. Krausz; Soumen K. Manna; Dong Wook Kang; Erik R. Anderson; Hans Luecke; Andrew D. Patterson; Yatrik M. Shah; Frank J. Gonzalez
    CELL METABOLISM, 16(5), 634-644, Nov. 2012, Refereed, Not invited
    LeadWebofScienceリポジトリ電子ジャーナル
  • Chronic exposure to rifaximin causes hepatic steatosis in pregnane X receptor-humanized mice.
    Jie Cheng; Kristopher W Krausz; Naoki Tanaka; Frank J Gonzalez
    Toxicological sciences : an official journal of the Society of Toxicology, 129(2), 456-68, Oct. 2012, Refereedリポジトリ電子ジャーナル
  • Colonoscopic enema as rescue for inadequate bowel preparation before colonoscopy: a prospective, observational study
    A. Horiuchi; Y. Nakayama; M. Kajiyama; N. Kato; T. Kamijima; Y. Ichise; N. Tanaka
    Colorectal Disease, 14(10), Sep. 2012, Refereed
    Lastリポジトリ電子ジャーナル
  • Invasive colorectal cancer within 5 years of negative colonoscopy in a Japanese population
    A. Horiuchi; Y. Nakayama; M. Kajiyama; T. Kamijima; N. Tanaka
    Colorectal Disease, 14(9), 1090-1094, Aug. 2012, Refereed
    Lastリポジトリ電子ジャーナル
  • Long-term outcome of Japanese patients with type 1 autoimmune hepatitis.
    Kaname Yoshizawa; Akihiro Matsumoto; Tetsuya Ichijo; Takeji Umemura; Satoru Joshita; Michiharu Komatsu; Naoki Tanaka; Eiji Tanaka; Masao Ota; Yoshihiko Katsuyama; Kendo Kiyosawa; Masanori Abe; Morikazu Onji
    Hepatology (Baltimore, Md.), 56(2), 668-76, Aug. 2012, Refereedリポジトリ電子ジャーナル
  • Metabolomics reveals an essential role for peroxisome proliferator-activated receptor alpha in bile acid homeostasis
    Fei Li; Andrew D. Patterson; Kristopher W. Krausz; Naoki Tanaka; Frank J. Gonzalez
    JOURNAL OF LIPID RESEARCH, 53(8), 1625-1635, Aug. 2012, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Safety and effectiveness of propofol sedation during and after outpatient colonoscopy.
    Akira Horiuchi; Yoshiko Nakayama; Masashi Kajiyama; Naoyuki Kato; Tetsuya Kamijima; Yasuyuki Ichise; Naoki Tanaka
    World journal of gastroenterology, 18(26), 3420-5, Jul. 2012, Refereed
    Lastリポジトリ電子ジャーナル
  • Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis
    Naoki Tanaka; Tsutomu Matsubara; Kristopher W. Krausz; Andrew D. Patterson; Frank J. Gonzalez
    HEPATOLOGY, 56(1), 118-129, Jul. 2012, Refereed, Not invited
    LeadWebofScienceリポジトリ電子ジャーナル
  • The modulation of hepatic adenosine triphosphate and inflammation by eicosapentaenoic acid during severe fibrotic progression in the SHRSP5/Dmcr rat model.
    Xiaofang Jia; Hisao Naito; Husna Yetti; Hazuki Tamada; Kazuya Kitamori; Yumi Hayashi; Nozomi Yamagishi; Dong Wang; Yukie Yanagiba; Yuki Ito; Juncai Wang; Naoki Tanaka; Katsumi Ikeda; Yukio Yamori; Tamie Nakajima
    Life sciences, 90(23-24), 934-43, Jun. 2012, Refereedリポジトリ電子ジャーナル
  • Clinical Characteristics of Young-Onset Ischemic Colitis
    Takefumi Kimura; Akihiro Shinji; Akira Horiuchi; Naoki Tanaka; Tadanobu Nagaya; Takashi Shigeno; Naoshi Nakamura; Michiharu Komatsu; Takeji Umemura; Norikazu Arakura; Akihiro Matsumoto; Eiji Tanaka
    DIGESTIVE DISEASES AND SCIENCES, 57(6), 1652-1659, Jun. 2012, Refereed, Not invited
    CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Attenuation of kidney injuries maintains serum sulfatide levels dependent on hepatic synthetic ability: a possible involvement of oxidative stress.
    Xiaona Sheng; Takero Nakajima; Lixuan Wang; Xiaowei Zhang; Yuji Kamijo; Kyoko Takahashi; Naoki Tanaka; Eiko Sugiyama; Mamoru Kyogashima; Toshifumi Aoyama; Atsushi Hara
    The Tohoku journal of experimental medicine, 227(1), 1-12, May 2012, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Endoscopic decompression of benign large bowel obstruction using a transanal drainage tube
    A. Horiuchi; Y. Nakayama; M. Kajiyama; T. Kamijima; N. Kato; Y. Ichise; N. Tanaka
    Colorectal Disease, 14(5), 623-627, Mar. 2012, Refereed
    Lastリポジトリ電子ジャーナル
  • Psychomotor recovery and blood propofol level in colonoscopy when using propofol sedation.
    Akira Horiuchi; Yoshiko Nakayama; Hideyasu Fujii; Yoshihiko Katsuyama; Shigeru Ohmori; Naoki Tanaka
    Gastrointestinal endoscopy, 75(3), 506-12, Mar. 2012, Refereed
    Lastリポジトリ電子ジャーナル
  • PPAR alpha is down-regulated following liver transplantation in mice
    Kan Nakagawa; Naoki Tanaka; Miwa Morita; Atsushi Sugioka; Shin-ichi Miyagawa; Frank J. Gonzalez; Toshifumi Aoyama
    JOURNAL OF HEPATOLOGY, 56(3), 586-594, Mar. 2012, Refereed, Not invited
    Lead, CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Effectiveness of outpatient percutaneous endoscopic gastrostomy replacement using esophagogastroduodenoscopy and propofol sedation.
    Akira Horiuchi; Yoshiko Nakayama; Masashi Kajiyama; Naoki Tanaka
    World journal of gastrointestinal endoscopy, 4(2), 45-9, Feb. 2012, Refereed
    Lastリポジトリ電子ジャーナル
  • Modulation of ammonium perfluorooctanoate-induced hepatic damage by genetically different PPARα in mice.
    Tomohiko Nakagawa; Doni Hikmat Ramdhan; Naoki Tanaka; Hisao Naito; Hazuki Tamada; Yuki Ito; Yufei Li; Yumi Hayashi; Nozomi Yamagishi; Yukie Yanagiba; Toshifumi Aoyama; Frank J Gonzalez; Tamie Nakajima
    Archives of toxicology, 86(1), 63-74, Jan. 2012, Refereedリポジトリ電子ジャーナル
  • Hepatic Cerebroside Sulfotransferase Is Induced by PPARα Activation in Mice.
    Takefumi Kimura; Takero Nakajima; Yuji Kamijo; Naoki Tanaka; Lixuan Wang; Atsushi Hara; Eiko Sugiyama; Eiji Tanaka; Frank J Gonzalez; Toshifumi Aoyama
    PPAR research, 2012, 174932-174932, 2012, Refereedリポジトリ電子ジャーナル
  • Fatty Acid Accumulation and Resulting PPARα Activation in Fibroblasts due to Trifunctional Protein Deficiency.
    Masato Wakabayashi; Yuji Kamijo; Takero Nakajima; Naoki Tanaka; Eiko Sugiyama; Tian Yangyang; Takefumi Kimura; Toshifumi Aoyama
    PPAR research, 2012, 371691-371691, 2012, Refereedリポジトリ電子ジャーナル
  • Clinical characteristics of de novo nonalcoholic fatty liver disease following pancreaticoduodenectomy
    Naoki Tanaka; Akira Horiuchi; Takahide Yokoyama; Gengo Kaneko; Naoto Horigome; Takahiro Yamaura; Tadanobu Nagaya; Michiharu Komatsu; Kenji Sano; Shin-ichi Miyagawa; Toshifumi Aoyama; Eiji Tanaka
    JOURNAL OF GASTROENTEROLOGY, 46(6), 758-768, Jun. 2011, Refereed, Not invited
    Lead, CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Lithocholic Acid Disrupts Phospholipid and Sphingolipid Homeostasis Leading to Cholestasis in Mice
    Tsutomu Matsubara; Naoki Tanaka; Andrew D. Patterson; Joo-Youn Cho; Kristopher W. Krausz; Frank J. Gonzalez
    HEPATOLOGY, 53(4), 1282-1293, Apr. 2011, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Prospective randomized comparison of cold snare polypectomy and conventional polypectomy for small colorectal polyps.
    Yasuyuki Ichise; Akira Horiuchi; Yoshiko Nakayama; Naoki Tanaka
    Digestion, 84(1), 78-81, 2011, Refereed
    Lastリポジトリ電子ジャーナル
  • Accurate and simple method for quantification of hepatic fat content using magnetic resonance imaging: a prospective study in biopsy-proven nonalcoholic fatty liver disease
    Tomoko Hatta; Yasunari Fujinaga; Masumi Kadoya; Hitoshi Ueda; Hiroaki Murayama; Masahiro Kurozumi; Kazuhiko Ueda; Michiharu Komatsu; Tadanobu Nagaya; Satoru Joshita; Ryo Kodama; Eiji Tanaka; Tsuyoshi Uehara; Kenji Sano; Naoki Tanaka
    JOURNAL OF GASTROENTEROLOGY, 45(12), 1263-1271, Dec. 2010, Refereed, Not invited
    LastWebofScienceリポジトリ電子ジャーナル
  • Differential response to trichloroethylene-induced hepatosteatosis in wild-type and PPARalpha-humanized mice.
    Doni Hikmat Ramdhan; Michihiro Kamijima; Dong Wang; Yuki Ito; Hisao Naito; Yukie Yanagiba; Yumi Hayashi; Naoki Tanaka; Toshifumi Aoyama; Frank J Gonzalez; Tamie Nakajima
    Environmental health perspectives, 118(11), 1557-63, Nov. 2010, Refereedリポジトリ電子ジャーナル
  • Eicosapentaenoic acid improves hepatic steatosis independent of PPAR alpha activation through inhibition of SREBP-1 maturation in mice
    Naoki Tanaka; Xiuguo Zhang; Eiko Sugiyama; Hiroyuki Kono; Akira Horiuchi; Takero Nakajima; Hiroki Kanbe; Eiji Tanaka; Frank J. Gonzalez; Toshifumi Aoyama
    BIOCHEMICAL PHARMACOLOGY, 80(10), 1601-1612, Nov. 2010, Refereed, Not invited
    LeadWebofScienceリポジトリ電子ジャーナル
  • Techniques and Outcomes of Endoscopic Decompression Using Transanal Drainage Tube Placement for Acute Left-sided Colorectal Obstruction.
    Yasuyuki Ichise; Akira Horiuchi; Yoshiko Nakayama; Naoki Tanaka
    Gastroenterology research, 3(5), 201-206, Oct. 2010, Refereed
    Lastリポジトリ
  • Association between serum uric acid levels and cardiometabolic risk factors among Japanese junior high school students.
    Minoru Hongo; Hiroya Hidaka; Shigeko Sakaguchi; Keisuke Nakanishi; Motoki Ichikawa; Naoko Hirota; Naoki Tanaka; Goro Tsuruta; Yoshikazu Yazaki; Osamu Kinoshita; Uichi Ikeda; Kenichi Koike
    Circulation journal : official journal of the Japanese Circulation Society, 74(8), 1570-7, Aug. 2010, Refereedリポジトリ
  • Effect of Traditional Japanese Medicine, Daikenchuto (TJ-100) in Patients With Chronic Constipation.
    Akira Horiuchi; Yoshiko Nakayama; Naoki Tanaka
    Gastroenterology research, 3(4), 151-155, Aug. 2010, Refereed
    Lastリポジトリ
  • Serum Fragmented Cytokeratin 18 Levels Reflect the Histologic Activity Score of Nonalcoholic Fatty Liver Disease More Accurately Than Serum Alanine Aminotransferase Levels
    Masaru Tsutsui; Naoki Tanaka; Masatomo Kawakubo; Yo Sheena; Akira Horiuchi; Michiharu Komatsu; Tadanobu Nagaya; Satoru Joshita; Takeji Umemura; Tetsuya Ichijo; Akihiro Matsumoto; Kaname Yoshizawa; Toshifumi Aoyama; Eiji Tanaka; Kenji Sano
    JOURNAL OF CLINICAL GASTROENTEROLOGY, 44(6), 440-447, Jul. 2010, Refereed, Not invited
    Lead, CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Twenty- or 24F-diameter dilation prevents severe bleeding associated with 27F-diameter dilation for direct percutaneous endoscopic gastrostomy tube placement
    Akira Horiuchi; Yoshiko Nakayama; Naoki Tanaka
    Gastroenterology Insights, 2(1), 8-8, Jun. 2010, Refereed
    Lastリポジトリ電子ジャーナル
  • Biliary stenting in the management of large or multiple common bile duct stones.
    Akira Horiuchi; Yoshiko Nakayama; Masashi Kajiyama; Naoyuki Kato; Tetsuya Kamijima; David Y Graham; Naoki Tanaka
    Gastrointestinal endoscopy, 71(7), 1200-1203, Jun. 2010, Refereed
    Lastリポジトリ電子ジャーナル
  • Nonalcoholic fatty liver disease in Japanese junior high school students: its prevalence and relationship to lifestyle habits
    Goro Tsuruta; Naoki Tanaka; Minoru Hongo; Michiharu Komatsu; Akira Horiuchi; Kaeko Hamamoto; Chieko Iguchi; Yoshiko Nakayama; Takeji Umemura; Tetsuya Ichijo; Akihiro Matsumoto; Kaname Yoshizawa; Toshifumi Aoyama; Eiji Tanaka
    JOURNAL OF GASTROENTEROLOGY, 45(6), 666-672, Jun. 2010, Refereed, Not invited
    Lead, CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Hood-assisted colonoscopy is more effective in detection of colorectal adenomas than narrow-band imaging.
    Akira Horiuchi; Yoshiko Nakayama; Naoyuki Kato; Yasuyuki Ichise; Masashi Kajiyama; Naoki Tanaka
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 8(4), 379-83, Apr. 2010, Refereed
    Lastリポジトリ電子ジャーナル
  • Multiple roles of PPARalpha in brown adipose tissue under constitutive and cold conditions.
    Makiko Komatsu; Yuhong Tong; Yufeng Li; Takero Nakajima; Gang Li; Rui Hu; Eiko Sugiyama; Yuji Kamijo; Naoki Tanaka; Atsushi Hara; Toshifumi Aoyama
    Genes to cells : devoted to molecular & cellular mechanisms, 15(2), 91-100, Feb. 2010, Refereedリポジトリ電子ジャーナル
  • Effect of bezafibrate on hepatic oxidative stress: comparison between conventional experimental doses and clinically-relevant doses in mice.
    Takero Nakajima; Naoki Tanaka; Gang Li; Rui Hu; Yuji Kamijo; Atsushi Hara; Toshifumi Aoyama
    Redox report : communications in free radical research, 15(3), 123-30, 2010, Refereed
    Correspondingリポジトリ電子ジャーナル
  • Conventional Diet Therapy for Hyperammonemia is Risky in the Treatment of Hepatic Encephalopathy Associated with Citrin Deficiency
    Fukushima, Kazuhiro; Yazaki, Masahide; Nakamura, Mio; Tanaka, Naoki; Kobayashi, Keiko; Saheki, Takeyori; Takei, Hideki; Ikeda, Shu-ichi
    INTERNAL MEDICINE, 49(3), 243-247, 2010, Refereed, Not invitedリポジトリ電子ジャーナル
  • DOWN-REGULATION OF SREBP-1C IS ASSOCIATED WITH THE DEVELOPMENT OF BURNED-OUT NASH
    T. Nagaya; N. Tanaka; M. Komatsu; S. Joshita; T. Umemura; T. Ichijo; A. Matsumoto; K. Yoshizawa; T. Aoyama; E. Tanaka
    JOURNAL OF HEPATOLOGY, 52(4), S373-S374, 2010, Refereed, Not invited
    Lead, CorrespondingWebofScienceリポジトリ
  • Low-dose propofol sedation for diagnostic esophagogastroduodenoscopy: results in 10,662 adults.
    Akira Horiuchi; Yoshiko Nakayama; Nao Hidaka; Yasuyuki Ichise; Masashi Kajiyama; Naoki Tanaka
    The American journal of gastroenterology, 104(7), 1650-5, Jul. 2009, Refereed
    Lastリポジトリ電子ジャーナル
  • 一般中学生の高尿酸血症と生活習慣病との関連
    本郷 実; 日高 宏哉; 阪口 しげ子; 市川 元基; 池田 宇一; 田中 直樹; 鶴田 悟郎; 小池 健一
    痛風と核酸代謝 = Gout and nucleic acid metabolism, 33(1), 17-26, Jul. 2009, Refereed, Not invited
  • Efficacy and safety of addition of minor bloodletting (petit phlebotomy) in hepatitis C virus-infected patients receiving regular glycyrrhizin injections
    Naoki Tanaka; Akira Horiuchi; Takahiro Yamaura; Michiharu Komatsu; Takahide Yokoyama; Shinji Okaniwa; Tadanobu Nagaya; Kaname Yoshizawa; Kendo Kiyosawa; Toshifumi Aoyama; Eiji Tanaka
    JOURNAL OF GASTROENTEROLOGY, 44(6), 577-582, Jun. 2009, Refereed, Not invited
    Lead, CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Polyenephosphatidylcholine prevents alcoholic liver disease in PPAR alpha-null mice through attenuation of increases in oxidative stress
    Wataru Okiyama; Naoki Tanaka; Tamie Nakajima; Eiji Tanaka; Kendo Kiyosawa; Frank J. Gonzalez; Toshifumi Aoyama
    JOURNAL OF HEPATOLOGY, 50(6), 1236-1246, Jun. 2009, Refereed, Not invited
    Lead, CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Bezafibrate at Clinically Relevant Doses Decreases Serum/Liver Triglycerides via Down-Regulation of Sterol Regulatory Element-Binding Protein-1c in Mice: A Novel Peroxisome Proliferator-Activated Receptor alpha-Independent Mechanism
    Takero Nakajima; Naoki Tanaka; Hiroki Kanbe; Atsushi Hara; Yuji Kamijo; Xiaowei Zhang; Frank J. Gonzalez; Toshifumi Aoyama
    MOLECULAR PHARMACOLOGY, 75(4), 782-792, Apr. 2009, Refereed, Not invited
    CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Hepatitis C Virus, Splenic Vein Thrombosis, and Lymphoma
    Naoki Tanaka; Takahide Yokoyama; Akira Horiuchi
    CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 7(2), XXIV-XXIV, Feb. 2009, Refereed, Not invited
    Lead, CorrespondingWebofScienceリポジトリ電子ジャーナル
  • 広範囲の肝実質の脱落により奇異な肝形態を呈し自己免疫性肝炎が疑われた1例
    城下 智; 一條 哲也; 吉澤 要; 福島 万奈; 小松 通治; 新井 薫; 田中 直樹; 梅村 武司; 松本 晶博; 田中 榮司
    日本消化器内視鏡学会雑誌 = Gastroenterological endoscopy, 51(1), 48-54, Jan. 2009, Refereed, Not invitedリポジトリ電子ジャーナル
  • Prospective comparison between sedated high-definition oral and unsedated ultrathin transnasal esophagogastroduodenoscopy in the same subjects: pilot study.
    Akira Horiuchi; Yoshiko Nakayama; Nao Hidaka; Yasuyuki Ichise; Masashi Kajiyama; Naoki Tanaka
    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 21(1), 24-8, Jan. 2009, Refereed
    Lastリポジトリ電子ジャーナル
  • Primitive Neuroectodermal Tumor as a Differential Diagnosis of CD56-Positive Tumors in Adults
    Nagaya, Tadanobu; Tanaka, Naoki; Kamijo, Atsushi; Joshita, Satoru; Nakazawa, Koh; Miyabayashi, Hideharu; Yoneda, Suguru; Ito, Tetsuya; Komatsu, Michiharu; Tanaka, Eiji; Kitano, Kiyoshi
    INTERNAL MEDICINE, 48(15), 1267-1272, 2009, Refereed, Not invited
    Correspondingリポジトリ電子ジャーナル
  • Pretreatment prediction of virological response to peginterferon plus ribavirin therapy in chronic hepatitis C patients using viral and host factors.
    Haruaki Shirakawa; Akihiro Matsumoto; Satoru Joshita; Michiharu Komatsu; Naoki Tanaka; Takeji Umemura; Tetsuya Ichijo; Kaname Yoshizawa; Kendo Kiyosawa; Eiji Tanaka
    Hepatology (Baltimore, Md.), 48(6), 1753-60, Dec. 2008, Refereedリポジトリ電子ジャーナル
  • Peroxisome Proliferator-Activated Receptor Alpha (PPARα) : The Association with Pathogenesis of Fatty Liver Disease
    TANAKA, Naoki; AOYAMA, Toshifumi
    The Shinshu Medical Journal, 56(6), 347-358, Dec. 2008, Refereed, Not invited
    Lead, Correspondingリポジトリ電子ジャーナル
  • Citrin deficiency as a cause of chronic liver disorder mimicking non-alcoholic fatty liver disease
    Michiharu Komatsu; Masahide Yazaki; Naoki Tanaka; Kenji Sano; Etsuko Hashimoto; Yo-ichi Taker; Yuan-Zong Song; Eiji Tanaka; Kendo Kiyosawa; Takeyori Saheki; Toshifumi Aoyama; Keiko Kobayashi
    JOURNAL OF HEPATOLOGY, 49(5), 810-820, Nov. 2008, Refereed, Not invited
    CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Development from simple steatosis to liver cirrhosis and hepatocellular carcinoma: a 27-year follow-up case.
    Tadanobu Nagaya; Naoki Tanaka; Michiharu Komatsu; Tetsuya Ichijo; Kenji Sano; Akira Horiuchi; Satoru Joshita; Takeji Umemura; Akihiro Matsumoto; Kaname Yoshizawa; Toshifumi Aoyama; Kendo Kiyosawa; Eiji Tanaka
    Clinical journal of gastroenterology, 1(3), 116-121, Oct. 2008, Refereed
    Correspondingリポジトリ電子ジャーナル
  • Transgastric Diversion of Transnasal Long Tube Placement Using a Percutaneous Endoscopic Gastrostomy Site in a Patient with Bowel Obstruction and Massive Ascites due to Ovarian Carcinoma.
    Akira Horiuchi; Yoshiko Nakayama; Naoki Tanaka
    Case reports in gastroenterology, 2(3), 326-9, Sep. 2008, Refereed
    Lastリポジトリ電子ジャーナル
  • Prospective randomized trial comparing the direct method using a 24 Fr bumper-button-type device with the pull method for percutaneous endoscopic gastrostomy
    A. Horiuchi; Y. Nakayama; N. Tanaka; H. Fujii; M. Kajiyama
    Endoscopy, 40(09), 722-726, Sep. 2008, Refereedリポジトリ電子ジャーナル
  • Insulin resistance and hepatitis C virus: a case-control study of non-obese, non-alcoholic and non-steatotic hepatitis virus carriers with persistently normal serum aminotransferase
    Naoki Tanaka; Tadanobu Nagaya; Michiharu Komatsu; Akira Horiuchi; Goro Tsuruta; Haruaki Shirakawa; Takeji Umemura; Tetsuya Ichijo; Akihiro Matsumoto; Kaname Yoshizawa; Toshifumi Aoyama; Kendo Kiyosawa; Eiji Tanaka
    LIVER INTERNATIONAL, 28(8), 1104-1111, Sep. 2008, Refereed, Not invited
    Lead, CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Eicosapentaenoic acid lowers plasma and liver cholesterol levels in the presence of peroxisome proliferators-activated receptor alpha.
    Eiko Sugiyama; Yasuko Ishikawa; Yufeng Li; Tomoko Kagai; Misaki Nobayashi; Naoki Tanaka; Yuji Kamijo; Shin Yokoyama; Atsushi Hara; Toshifumi Aoyama
    Life sciences, 83(1-2), 19-28, Jul. 2008, Refereedリポジトリ電子ジャーナル
  • Cholesterol-lowering effect of bezafibrate is independent of peroxisome proliferator-activated receptor activation in mice
    Takero Nakajima; Naoki Tanaka; Eiko Sugiyama; Yuji Kamijo; Atsushi Hara; Rui Hu; Gang Li; Yufeng Li; Kozo Nakamura; Frank J. Gonzalez; Toshifumi Aoyama
    BIOCHEMICAL PHARMACOLOGY, 76(1), 108-119, Jul. 2008, Refereed, Not invited
    CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Molecular mechanism of age-specific hepatic lipid accumulation in PPARalpha (+/-):LDLR (+/-) mice, an obese mouse model.
    Yufeng Li; Eiko Sugiyama; Shin Yokoyama; Lingling Jiang; Naoki Tanaka; Toshifumi Aoyama
    Lipids, 43(4), 301-12, Apr. 2008, Refereedリポジトリ電子ジャーナル
  • Highly purified eicosapentaenoic acid treatment improves nonalcoholic steatohepatitis
    Naoki Tanaka; Kenji Sano; Akira Horiuchi; Eiji Tanaka; Kendo Kiyosawa; Toshifumi Aoyama
    JOURNAL OF CLINICAL GASTROENTEROLOGY, 42(4), 413-418, Apr. 2008, Refereed, Not invited
    Lead, CorrespondingWebofScienceリポジトリ
  • PPAR alpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice
    Naoki Tanaka; Kyoji Moriya; Kendo Kiyosawa; Kazuhiko Koike; Frank J. Gonzalez; Toshifurni Aoyama
    JOURNAL OF CLINICAL INVESTIGATION, 118(2), 683-694, Feb. 2008, Refereed, Not invited
    Lead, CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Pancreatic exocrine insufficiency: A rare cause of nonalcoholic steatohepatitis
    Naoki Tanaka; Akira Horiuchi; Takahide Yokoyama; Shigeyuki Kawa; Kendo Kiyosawa
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 103(1), 245-246, Jan. 2008, Refereed, Not invited
    Lead, CorrespondingWebofScienceリポジトリ
  • Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: Implications for HCV-associated hepatocarcinogenesis
    Naoki Tanaka; Kyoji Moriya; Kendo Kiyosawa; Kazuhiko Koike; Toshifumi Aoyama
    INTERNATIONAL JOURNAL OF CANCER, 122(1), 124-131, Jan. 2008, Refereed, Not invited
    Lead, CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Propofol sedation for endoscopic procedures in patients 90 years of age and older.
    Akira Horiuchi; Yoshiko Nakayama; Naoki Tanaka; Yasuyuki Ichise; Yoshihiko Katsuyama; Shigeru Ohmori
    Digestion, 78(1), 20-3, 2008, Refereedリポジトリ電子ジャーナル
  • Safety and driving ability following low-dose propofol sedation.
    Akira Horiuchi; Yoshiko Nakayama; Yoshihiko Katsuyama; Shigeru Ohmori; Yasuyuki Ichise; Naoki Tanaka
    Digestion, 78(4), 190-4, 2008, Refereed
    Lastリポジトリ電子ジャーナル
  • 腹壁への浸潤が疑われ, 画像検査が診断の契機となった肝放線菌症の1例
    武藤 英知; 一條 哲也; 小林 倫子; 田中 直樹; 梅村 武司; 小松 通治; 松本 晶博; 吉澤 要; 田中 榮司; 上田 和彦; 角谷 眞澄; 清澤 研道
    肝臓 = ACTA HEPATOLOGICA JAPONICA, 48(11), 553-558, Nov. 2007, Refereed, Not invitedリポジトリ電子ジャーナル
  • Differential effects of aging, drinking and exercise on serum cholesterol levels dependent on the PPARA-V227A polymorphism.
    Hisao Naito; Michihiro Kamijima; Osamu Yamanoshita; Ai Nakahara; Takahiko Katoh; Naoki Tanaka; Toshifumi Aoyama; Frank J Gonzalez; Tamie Nakajima
    Journal of occupational health, 49(5), 353-62, Sep. 2007, Refereedリポジトリ
  • Effect of precut sphincterotomy on biliary cannulation based on the characteristics of the major duodenal papilla.
    Akira Horiuchi; Yoshiko Nakayama; Masashi Kajiyama; Naoki Tanaka
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 5(9), 1113-8, Sep. 2007, Refereed
    Lastリポジトリ
  • A lean man with nonalcoholic fatty liver disease
    Naoki Tanaka; Masahide Yazaki; Keiko Kobayashi
    CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 5(3), XXXII-XXXII, Mar. 2007, Refereed, Not invited
    Lead, CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Efficacy and safety of 6-month iron reduction therapy in patients with hepatitis C virus-related cirrhosis: a pilot study
    Naoki Tanaka; Akira Horiuchi; Takahiro Yamaura; Michiharu Komatsu; Eiji Tanaka; Kendo Kiyosawa
    JOURNAL OF GASTROENTEROLOGY, 42(1), 49-55, Jan. 2007, Refereed, Not invited
    Lead, CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Useful parameters for distinguishing nonalcoholic steatohepatitis with mild steatosis from cryptogenic chronic hepatitis in the Japanese population
    Naoki Tanaka; Eiji Tanaka; Yo Sheena; Michiharu Komatsu; Wataru Okiyama; Noriko Misawa; Hidetomo Muto; Takeji Umemura; Tetsuya Ichijo; Akihiro Matsumoto; Kaname Yoshizawa; Akira Horiuchi; Kendo Kiyosawa
    LIVER INTERNATIONAL, 26(8), 956-963, Oct. 2006, Refereed, Not invited
    Lead, CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Peroxisome proliferator-activated receptor alpha-independent peroxisome proliferation
    Xiuguo Zhang; Naoki Tanaka; Takero Nakajuna; Yuji Kamijo; Frank J. Gonzalez; Toshifumi Aoyama
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 346(4), 1307-1311, Aug. 2006, Refereed, Not invited
    CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Nasopharyngeal decolonization of methicillin-resistant Staphylococcus aureus can reduce PEG peristomal wound infection.
    Akira Horiuchi; Yoshiko Nakayama; Masashi Kajiyama; Hideyasu Fujii; Naoki Tanaka
    The American journal of gastroenterology, 101(2), 274-7, Feb. 2006, Refereed
    Lastリポジトリ
  • Laparoscopic findings in patients with nonalcoholic steatohepatitis
    N Tanaka; T Ichijo; W Okiyama; H Mutou; N Misawa; A Matsumoto; K Yoshizawa; E Tanaka; K Kiyosawa
    LIVER INTERNATIONAL, 26(1), 32-38, Feb. 2006, Refereed, Not invited
    Lead, CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Haploinsufficiency in the PPARα and LDL receptor genes leads to gender- and age-specific obesity and hyperinsulinemia.
    SUGIYAMA Eiko; SUGIYAMA Eiko; TANAKA Naoki; NAKAJIMA Tamie; KAMIJO Yuji; YOKOYAMA Shin; LI Yufeng; GONZALEZ Frank J; AOYAMA Toshifumi
    Biochem Bioph Res Co, 350(2), 370-376, 2006, Refereed, Not invitedリポジトリ電子ジャーナル
  • Acute colorectal obstruction treated by means of transanal drainage tube: effectiveness before surgery and stenting.
    Akira Horiuchi; Yoshiko Nakayama; Naoki Tanaka; Masashi Kajiyama; Hideyasu Fujii; Takahide Yokoyama; Ken Hayashi
    The American journal of gastroenterology, 100(12), 2765-70, Dec. 2005, Refereedリポジトリ
  • Suppression of expression of muscle-associated proteins by PPARalpha in brown adipose tissue.
    Yuhong Tong; Atsushi Hara; Makiko Komatsu; Naoki Tanaka; Yuji Kamijo; Frank J Gonzalez; Toshifumi Aoyama
    Biochemical and biophysical research communications, 336(1), 76-83, Oct. 2005, Refereedリポジトリ
  • Usefulness of a small-caliber, variable-stiffness colonoscope as a backup in patients with difficult or incomplete colonoscopy.
    Akira Horiuchi; Yoshiko Nakayama; Masashi Kajiyama; Hideyasu Fujii; Naoki Tanaka
    The American journal of gastroenterology, 99(10), 1936-40, Oct. 2004, Refereed
    Lastリポジトリ
  • Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage
    T Nakajima; Y Kamijo; N Tanaka; E Sugiyama; E Tanaka; K Kiyosawa; Y Fukushima; JM Peters; FJ Gonzalez; T Aoyama
    HEPATOLOGY, 40(4), 972-980, Oct. 2004, Refereed, Not invited
    CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Phlebotomy: a promising treatment for chronic hepatitis C
    N Tanaka; K Kiyosawa
    JOURNAL OF GASTROENTEROLOGY, 39(6), 601-603, Jun. 2004, Refereed, Not invited
    Lead, CorrespondingWebofScienceリポジトリ電子ジャーナル
  • Ribavirin-induced pure red-cell aplasia during treatment of chronic hepatitis C.
    Naoki Tanaka; Fumihiro Ishida; Eiji Tanaka
    The New England journal of medicine, 350(12), 1264-5, Mar. 2004, Refereed
    Leadリポジトリ
  • In vivo stabilization of nuclear retinoid X receptor alpha in the presence of peroxisome proliferator-activated receptor alpha
    N Tanaka; K Hora; H Makishima; Y Kamijo; K Kiyosawa; FJ Gonzalez; T Aoyama
    FEBS LETTERS, 543(1-3), 120-124, May 2003, Refereed, Not invited
    LeadWebofScienceリポジトリ電子ジャーナル
  • Development of hepatocellular carcinoma after longterm sustained complete response to interferon therapy: what is the mechanism?
    N Tanaka; K Kiyosawa
    JOURNAL OF GASTROENTEROLOGY, 38(4), 417-419, Apr. 2003, Refereed, Not invited
    Lead, CorrespondingWebofScienceリポジトリ
  • 非アルコール性脂肪性肝炎
    田中 直樹; 清澤 研道
    肝臓, 43(12), 539-549, Dec. 2002, Refereed, Not invitedリポジトリ電子ジャーナル
  • A case of nephrotic syndrome due to lupus nephritis which was controlled with low-density lipoprotein apheresis.
    Yuji Kamijo; Yoko Kaneko; Toru Ichikawa; Nobuhiko Kobayashi; Takayuki Koyama; Tetsuji Kakegawa; Hiroshi Kamijo; Keiichi Kono; Satoshi Minami; Naoki Tanaka; Hideo Arakura; Masayuki Hirata; Makoto Higuchi; Kendo Kiyosawa; Kazuhiko Hora
    Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis, 6(6), 459-62, Dec. 2002, Refereedリポジトリ
  • 非アルコール性脂肪肝炎の発症機構とPPAR
    田中 直樹; 青山 俊文
    日本消化器病學會雜誌 = The Japanese journal of gastro-enterology, 99(6), 563-569, Jun. 2002, Refereed, Not invitedリポジトリ電子ジャーナル
  • Identification of functions of peroxisome proliferator-activated receptor α in proximal tubules.
    KAMIJO Y; HORA K; TANAKA N; USUDA N; KIYOSAWA K; NAKAJIMA T; GONZALEZ Fj; AOYAMA T
    J Am Soc Nephrol, 13(7), 1691-1702, 2002, Refereed, Not invitedリポジトリ電子ジャーナル
  • トピックス 4.Peroxisome proliferator-activated receptor(PPAR)
    田中 直樹; 青山 俊文
    日本内科学会雑誌, 90(10), 2033-2039, Oct. 2001, Refereed, Not invited
    Leadリポジトリ電子ジャーナル
  • Initiation of enzyme replacement therapy for an adult patient with asymptomatic type 1 Gaucher's disease
    N Tanaka; H Saito; T Ito; K Momose; F Ishida; K Hora; K Kiyosawa; H Ida
    INTERNAL MEDICINE, 40(8), 716-721, Aug. 2001, Refereed, Not invited
    Lead, CorrespondingWebofScienceリポジトリ
  • Age-dependent obesity and hyperinsulinemia in PPARα(+/–) LDLR(+/–) male mice.
    Sugiyama E; Tanaka N; Nakajima T; Kamijo Y; Aoyama T
    J Diabetes Complicat, 16, 51-56, 2001, Not invited
  • 脂肪肝とPPARα
    Aoyama T; Nakajima T; Tanaka N
    肝臓病学の進歩, 27(9), 1-7, 2001, Refereed, Not invited
  • Back pain out of the blue in a haemodialysis patient
    N Tanaka; H Kasahara; T Yoshie; K Hora; K Kiyosawa
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 14(7), 1792-1794, Jul. 1999, Refereed, Not invited
    Lead, CorrespondingWebofScienceリポジトリ

MISC

  • 【PPARα revisit】 PPARαと疾患 NASHとPPARα
    田中 直樹; 木村 岳史; 長屋 匡信; 小松 通治; 青山 俊文
    The Lipid, 27(4), 336 - 342, Oct. 2016, Not invited
  • Toll-like receptor 4とMyD 88がNAFLDの線維化に関連する
    小松 通治; 田中 直樹; 長屋 匡信; 市川 雪; 木村 岳史; 森田 進; 城下 智; 梅村 武司; 松本 晶博; 田中 榮司
    肝臓, 53(Suppl.1), A482 - A482, Apr. 2012, Not invited
  • 【NASH/NAFLDのUp to Date】 NASH/NAFLDの分子病態メカニズム Burned-out NASHの形成機構 肝細胞内の脂肪代謝関連遺伝子解析について
    小松 通治; 長屋 匡信; 田中 直樹; 田中 榮司
    肝・胆・膵, 60(6), 941 - 946, Jun. 2010, Not invited
  • 中学生における非アルコール性脂肪肝疾患(NAFLD)の頻度と生活習慣の検討
    小松 通治; 田中 直樹; 長屋 匡信; 田中 榮司
    肝臓, 51(Suppl.1), A388 - A388, Apr. 2010, Not invited
  • 膵・胆道疾患における消化吸収障害とその対策 膵頭十二指腸切除術後のNAFLD・その臨床像と発症機構
    長屋 匡信; 田中 直樹; 田中 榮司
    日本消化器病学会雑誌, 106(臨増大会), A723 - A723, Sep. 2009, Not invited
  • C型慢性肝炎1b型高ウイルス量患者に対するペグインターフェロンとリバビリン併用療法の治療効果に与える宿主およびウイルス因子の影響
    松本 晶博; 白川 晴章; 米沢 傑; 上條 敦; 長屋 匡信; 城下 智; 小松 通治; 田中 直樹; 梅村 武司; 一條 哲也; 吉澤 要; 太田 正穂; 勝山 善彦; 清澤 研道; 田中 榮司
    肝臓, 50(Suppl.1), A131 - A131, Apr. 2009, Not invited
  • 原発性胆汁性肝硬変患者におけるゲノムワイドマイクロサテライト解析の検討
    城下 智; 梅村 武司; 吉澤 要; 一條 哲也; 米田 傑; 上條 敦; 長屋 匡信; 小松 通治; 田中 直樹; 松本 晶博; 田中 榮司
    肝臓, 50(Suppl.1), A162 - A162, Apr. 2009, Not invited
  • NASHでは線維化進行に伴いなぜ肝脂肪沈着が減少するのか 肝生検組織を用いた脂質代謝関連分子の発現解析
    長屋 匡信; 田中 直樹; 上條 敦; 城下 智; 小松 通治; 梅村 武司; 一條 哲也; 松本 晶博; 吉澤 要; 田中 榮司
    肝臓, 50(Suppl.1), A211 - A211, Apr. 2009, Not invited
  • 血中サイトケラチン18値はNAFLD histological activity scoreを反映する有用なバイオマーカーである
    田中 直樹; 小松 通治; 長屋 匡信; 田中 榮司
    肝臓, 50(Suppl.1), A324 - A324, Apr. 2009, Not invited
  • C型慢性肝炎に対するペグインターフェロンα-2a+リバビリン併用療法の有効性・安全性に関する再治療例を含めた検討
    松本 晶博; 宜保 行雄; 米田 傑; 上條 敦; 長屋 匡信; 城下 智; 小松 通治; 田中 直樹; 梅村 武司; 一條 哲也; 吉澤 要; 田中 榮司
    肝臓, 50(Suppl.1), A349 - A349, Apr. 2009, Not invited
  • HCVはインスリン抵抗性を惹起するか 無症候性キャリアでの検討
    田中 直樹; 長屋 匡信; 田中 榮司
    肝臓, 49(Suppl.1), A215 - A215, Apr. 2008, Not invited
  • 肥満を伴わない非アルコール性脂肪肝疾患
    田中 直樹; 小松 通治; 白川 晴章; 長屋 匡信; 城下 智; 小林 倫子; 新井 薫; 梅村 武司; 一條 哲也; 松本 晶博; 吉澤 要; 田中 榮司
    長野県医学会雑誌, 38, 65 - 65, Mar. 2008, Not invited

Courses

  • 人間機能・形態学概論
    Shinshu University
  • 疾患予防医科学
    Shinshu University
  • 生化学
    Shinshu University

Affiliated academic society

  • 日本医学教育学会
  • The Japanese Biochemical Society
  • Japan Society of Metabolism and Clinical Nutrition
  • Japan Society of Hepatology
  • Japanese Society of Gastroenterology
  • Japanese Society of Internal Medicine
  • 日本糖尿病学会

Research Themes

  • 腎のPPARα機能・脂肪酸代謝の低下が腎臓病と全身臓器に及ぼす影響の解析
    科学研究費助成事業, 日本学術振興会, 基盤研究(C)
    信州大学
    01 Apr. 2025 - 31 Mar. 2029
  • Analyses of the effects of autophagy-fatty acid metabolism crosstalk on kidney dysfunction
    Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
    Shinshu University
    01 Apr. 2022 - 31 Mar. 2025
  • The study on novel brain aging mechanisms related to brain-specific lipids and development of preventive methods
    Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
    Shinshu University
    01 Apr. 2021 - 31 Mar. 2024
  • 食事中トランス脂肪酸による肝発癌促進機能の解明と予防法の開発
    科学研究費補助金(基盤研究(C)), 基盤研究(C)
    2019 - 2021
  • Elucidation of mechanism on hepatitis C-related liver cancer exacerbation by trans-fatty acid toxicity and development of preventive method
    Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
    Shinshu University
    01 Apr. 2016 - 31 Mar. 2019
  • 生体異物代謝を機軸とした非アルコール性脂肪肝炎発症機構の解明
    科学研究費補助金(基盤研究(C)), 基盤研究(C)
    2016 - 2018
  • Studies on a novel oxidative stress-reducing effect resulting from generation/excretion of sulfated glycolipids
    Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
    Shinshu University
    01 Apr. 2015 - 31 Mar. 2018
  • PPARα 活性化抑制を標的としたC型肝炎関連肝癌の予防法の開発
    科学研究費補助金(若手研究(B)), 若手研究(B)
    2009 - 2010
  • Elucidation of molecular mechanisms for alcohol-dependent inflammatory disorders in digestive tract and liver and development of their preventive methods
    Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
    Shinshu University
    2007 - 2008
  • PPARα ノックアウトマウスを用いたアルコール性肝障害の病態解析と治療法の開発
    科学研究費補助金(若手研究(B)), 若手研究(B)
    2007 - 2008
  • 共同研究, 米国国立衛生研究所 癌研究所 代謝部門
    2004
  • Global medical research and education
  • Hepatocarcinogenesis caused by hepatic steatosis/steatohepatitis
  • Functional foods for preventing obesity and fatty liver
  • PPARaノックアウトマウスを用いたアルコール性肝障害の病態解析と治療法の開発
    科学研究費補助金(若手研究(B))
  • Dietary Nutrients and Gastrointestinal Disease
  • Liver-adipose interaction
  • Lipid metabolism and nuclear receptor
  • Hepatocarcinogenesis caused by HCV core protein
  • Pathogenesis of nonalcoholic steatohepatitis and development of therapeutic strategies
  • Metabolomics

Social Contribution Activities

  • 本当は怖~い脂肪肝
    信毎メディアガーデン, 29 Jul. 2018
  • 食生活と生活習慣病
    lecturer
    信州ソルガム高度活用研究プロジェクトキックオフシンポジウム, 信州大学工学部, 20 Jun. 2017
  • 内臓肥満と糖尿病・高血圧-健診データのみかた–
    平成27年度生坂村ヘルスアップ教室, 生坂村, 22 Jan. 2017
  • 本当はこわい脂肪肝~小児から大人まで~
    安曇野市, 03 Jul. 2016
  • NAFLD/NASHの病態・診断と今後の展望
    lecturer
    第34回日本消化器病学会甲信越支部教育講演会, 信州大学, 2015

Media Coverage

  • 健康ばんざい 肝疾患
    長野放送, 24 Apr. 2021
  • こんにちはドクター『本当にこわい脂肪肝』
    SBCラジオ, 26 Mar. 2017, Media report
  • 奥様はホームドクター『本当はこわい脂肪肝』
    テレビ信州, 06 Mar. 2017, Media report

Thesis guidance

  • 2020, 1, 1, 5, 4, 2, 2
  • 2019, 2, 2, 5, 4, 1, 1
  • 2006, 1, 1, 1, 1
  • 2021, 5, 4, 0, 0
  • 2010, 5, 1, 5, 1
  • 2009, 1, 0, 1, 0
  • 2008, 2, 0, 2, 0
  • 2012, 1, 0, 1, 0
  • 2014, 2, 0, 2, 0

Acceptance of international students

  • 2018, 1, 1
  • 2016, 2, 2
  • 2019, 2, 0
  • 2017, 2, 2
  • 2020, 1, 0, 2人入学希望、COVID-19 のため1人は入学後休学、もう一人は入試を受験できず。

Dispatch overseas

  • 2017
    信州大学医学部顕彰 短期留学, 米国国立衛生研究所
  • 2016
    国際交流, ドイツ ドレスデン工科大学
  • 2016
    国際交流, インドネシア