Ph.D., Tohoku University

Animal production science, Dairy Science

2019
Professor, Faculty of Agriculture, Shinshu University

2019
Department Head, Department of Biomolecular Innovation, Institute for Biomedical Sciences, Shinshu University

2016 - 2019
Director, Research Center for Fungal and Microbial Dynamism, Shinshu University

2012 - 2019
Associate Professor, Faculty of Agriculture, Shinshu University

2007 - 2012
Assistant Professor, Fiber-Nanotech Young Researcher Empowerment Center, Shinshu University

2007 - 2007
Japan Society for Promotion of Science (JSPS) fellow for Research Abroad, National Cancer Institute (NCI) at Frederick

2006 - 2007
Japan Society for Promotion of Science (JSPS) fellow for Research Abroad, Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration

2003 - 2006, Tohoku University, Graduate School ofAgricultural Science, Division of Bioscience and Biotechnology for Future Bioindustries

2001 - 2003, Tohoku University, Graduate School of Agricultural Science, Division of Biological Resource Science

1997 - 2001, Tohoku University, Faculty of Agriculture, Applied Bio-Sciences

2023
評議員, 日本酪農科学会

2021 - 2024
Director, Japan Society for Lactic Acid Bacteria

2020
評議員, 北信越畜産学会

2020
大会長, 酪農科学シンポジウム2020

2019 - 2022
監事, 日本酪農科学会

2017 - 2019
監事, 北信越畜産学会

2016 - 2021
Councilor, Japan Society for Lactic Acid Bacteria

2017
Agriculture, Forestry and Fisheries Research Council, Award for Young Agricultural Researchers

2015
The Foundation of Agricultural Sciences of Japan, Japan Prize in Agricultural Science, Achievement Award for Young Scientists

2011
Japanese Society of Animal Science, Japanese Society of Animal Science Young Investigator's Award

2011
Animal Science Journal Excellent Paper Award 2011

2008
Animal Science Journal Excellent Paper Award 2008

2006
Dean’s Award of Graduate School of Agricultural Science of Tohoku University

2006
President’s Award of Tohoku University

2005
Award for Young Scientist from The Japanese Society of Dairy and Foodscience

2004
The Best Presentation Award for the 103rd annual meeting of Japanese Society of Animal Science

Oral administration of Limosilactobacillus ingluviei C37 inhibits Campylobacter jejuni colonization in chicks
Murakami A, Watanabe-Yanai A, Iwata T, Namai F, Sato T, Fujii T, Tochio T, Khempaka S, Shimosato T.
Frontiers in Microbiology, in press, Nov. 2024
Lead, Corresponding

Development of engineered IL-36γ-hypersecreting Lactococcus lactis to improve the intestinal environment
Yoda, M., Takase, S., Suzuki, K., Murakami, A., Namai, F., Sato, T., Fujii, T., Tochio, T. & Shimosato, T.
World Journal of Microbiology and Biotechnology, 40(11), 363, 24 Oct. 2024
Last, Corresponding

Koji Amazake Produced by Double Saccharification Contains More Isomaltose and Modifies the Gut Microbiota in Mice
Murakami, A., Saito, A., Namai, F., Fujii, T., Tochio, T., Toida, T. & Shimosato, T.
Frontiers in Nutrition, Oct. 2024
Last, Corresponding

Myogenic Anti-Nucleolin Aptamer iSN04 Inhibits Proliferation and Promotes Differentiation of Vascular Smooth Muscle Cells
Mana Miyoshi, Takeshi Shimosato, Tomohide Takaya
Biomolecules, 14(6), 709, 15 Jun. 2024

Ad libitum feeding of silkworm larvae powder-containing diets specifically influences metabolism-related and short-chain fatty acid-producing gut bacteria in mice
Murakami A, Yamaguchi H, Namai F, Sato T, Yamazaki M, Uehara H, Fujii T, Tochio T, Shiomi K, Shimosato T.
Frontiers in Cellular and Infection Microbiology, 14, 1383774, Jun. 2024
Last, Corresponding

Development of a single-chain fragment variable that binds to the SARS-CoV-2 spike protein produced by genetically modified lactic acid bacteria
Oshima S, Namai F, Sato T, Shimosato T.*
Molecular Biotechnology, 66(1), 151-160, Jan. 2024
Last, Corresponding

Development of the 12-base short dimeric myogenetic oligodeoxynucleotide that induces myogenic differentiation.
Umezawa K, Ikeda R, Sakamoto T, Enomoto Y, Nihashi Y, Shinji S, Shimosato T, Kagami H, Takaya T.
BioTech, 13(2), 11, 2024, Refereed

Assessment of lactic acid bacteria isolated from the chicken digestive tract for potential use as poultry probiotics
Sirisopapong S, Shimosato T., Okrathok S, Khempaka S.
ANIMAL BIOSCIENCE, 36(8), 1209-1220, Aug. 2023

Development of fluorescence-labeled antibody for immune checkpoint inhibitor using engineered probiotics
Namai F, Sumiya S, Nomura N, Sato T, Shimosato T.*
AMB Express, 13(4), 2023
Last, Corresponding

Oral administration of Brevibacterium linens from washed cheese increases short-chain fatty acid-producing bacteria and lactobacilli in the gut microbiota of mice
Murakami A, Toyomoto K, Namai F, Sato T, Fujii T, Tochio T, Shimosato T.
ANIMAL SCIENCE JOURNAL, 94(1), e13905, 2023
Last, Corresponding

Myogenetic oligodeoxynucleotide induces myocardial differentiation of murine pluripotent stem cells.
Ishioka M, Nihashi Y, Sunagawa Y, Umezawa K, Shimosato T, Kagami H, Morimoto T, Takaya T.
Int J Mol Sci, 24(18), 14380, 2023, Refereed

Identification of a novel osteogenetic oligodeoxynucleotide (osteoDN) that promotes osteoblast differentiation in a TLR9-independent manner.
Nihashi Y, Miyoshi M, Umezawa K, Shimosato T, Takaya T.
Nanomaterials, 12(10), 1680, 14 May 2022, Refereed

Myogenetic oligodeoxynucleotides as anti-nucleolin aptamers inhibit the growth of embryonal rhabdomyosarcoma cells.
Nohira N, Shinji S, Nakamura S, Nihashi Y, Shimosato T, Takaya T.
BIOMEDICINES, 10(11), 2691, 2022, Refereed
Last, Corresponding

Myogenetic oligodeoxynucleotide restores differentiation and reverses inflammation of myoblasts aggravated by cancer-conditioned medium
Nihashi Y, Yamamoto M, Shimosato T, Takaya T.
Muscles, 1(2), 111-120, 2022, Refereed

Free feeding of CpG-oligodeoxynucleotide particles prophylactically attenuates allergic airway inflammation and hyperresponsiveness in mice
Okajima, T., Shigemori S*, Namai F, Ogita T, Sato T, Shimosato T.*
Frontiers in immunology, 12, 738041, 19 Nov. 2021
Last, Corresponding

A soybean resistant protein-containing diet increased the production of Reg3g through the regulation of the gut microbiota and enhanced the intestinal barrier function in mice
Ogita T, Namai F, Mikami A, Ishiguro T, Umezawa K, Uyeno Y, Shimosato T.*
Frontiers in Nutrition, 8, 701466, 19 Aug. 2021
Last, Corresponding

Myogenetic oligodeoxynucleotide complexed with berberine promotes differentiation of chicken myoblasts.
Nihashi Y, Shinji S, Umezawa K, Shimosato T, Ono T, Kagami H, Takaya T
ANIMAL SCIENCE JOURNAL, 92(1), e13597, 25 Jul. 2021, Refereed

Myogenetic oligodeoxynucleotide (myoDN) recovers the differentiation of skeletal muscle myoblasts deteriorated by diabetes mellitus.
Nakamura S, Yonekura S, Shimosato T, Takaya T.
Frontiers in Physiology, 12, 679152, 24 May 2021

Identification of the myogenetic oligodeoxynucleotides (myoDNs) that promote differentiation of skeletal muscle myoblasts by targeting nucleolin
Shinji S, Umezawa K, Nihashi Y, Nakamura S, Shimosato T, Takaya T.
Frontiers in Cell and Developmental Biology, 6, 616706, 11 Jan. 2021

Oral administration of Flavonifractor plautii, a bacteria increased with green tea consumption, promotes recovery from acute colitis in mice via suppression of IL-17
Mikami A, Ogita T, Namai F, Shigemori S, Sato T, Shimosato T.*
Frontiers in Nutrition, 7:610946, 2021

Nasally Administered Lactococcus lactis Secreting Heme Oxygenase-1 Attenuates Murine Emphysema
Yumoto K, Sato T*, Nakashima K, Namai F, Shigemori S, Shimosato T, Kaneko T.
Antioxidants, 9(1049), 27 Oct. 2020

Ribosome-engineered Lacticaseibacillus rhamnosus GG exhibits cell surface GAPDH accumulation and enhanced adhesion to human colonic mucin
Ishida M, Namai F, Shigemori S, Kajikawa S, Tsukagoshi M, Sato T, Ogita T, Shimosato T.*
Applied and Environmental Microbiology, 86(20), e01448-20, 01 Oct. 2020

Oral priming with oligodeoxynucleotide particles from Lactobacillus rhamnosus GG attenuates symptoms of dextran sodium sulfate-induced acute colitis in mice
Shigemori S, Namai F, Ogita T, Sato T, Shimosato T.*
ANIMAL SCIENCE JOURNAL, 91(1), e13468, Oct. 2020

Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice
Namai F, Shigemori S, Ogita T, Sato T, Shimosato T.*
Experimental & Molecular Medicine, 52(9), 1627-1636, 28 Sep. 2020

Construction of genetically modified Lactococcus lactis producing anti-human-CTLA-4 single-chain fragment variable
Namai F, Murakami A, Ueda A, Tsukagoshi M, Shigemori S, Ogita T, Sato T, Shimosato T.*
Molecular Biotechnology, 62(11), 572-579, 23 Sep. 2020

Editorial: Nutrition, Immunity and Viral Infections
Villena J*, Shimosato T, Vizoso-Pinto MG, Kitazawa H.*
Frontiers in Nutrition, 7(125), 08 Sep. 2020

Construction of genetically modified Lactococcus lactis that produces bioactive anti-interleukin-4 single-chain fragment variable
Namai F, Shigemori S, Ogita T, Sato T, Shimosato T.*
Molecular Biology Reports, 47(9), 7039-7047, Sep. 2020

Oral administration of Flavonifractor plautii attenuates inflammatory responses in obese adipose tissue
Mikami A, Ogita T, Namai F, Shigemori S, Sato T, Shimosato T.*
Molecular Biology Reports, 47(9), 6717-6725, Sep. 2020

Lactobacillus ingluviei C37 from chicken inhibits inflammation in LPS-stimulated mouse macrophages
Tsukagoshi M, Sirisopapong M, Namai F, Ishida M, Okrathok S, Shigemori S, Ogita T, Sato T, Khempaka S*, Shimosato T.*
ANIMAL SCIENCE JOURNAL, 91:e13436, 30 Aug. 2020

Oral administration of Flavonifractor plautii strongly suppresses Th2 immune responses in mice
Ogita T, Yamamoto Y, Mikami A, Shigemori S, Sato T, Shimosato T.*
Frontiers in immunology, 11:379, 28 Feb. 2020

Cooperation of Oligodeoxynucleotides and Synthetic Molecules as Enhanced Immune Modulators
Nigar S, Shimosato T.*
Frontiers in Nutrition, 6, 140, 27 Aug. 2019

Septicemia fromLactobacillus rhamnosus GG, from a Probiotic Enriched Yogurt, in a Patient with Autologous Stem Cell Transplantation
Koyama S, Fujita H, Shimosato T, Kamijo A, Ishiyama Y, Yamamoto E, Ishii Y, Hattori Y, Hagiwara M, Yamazaki E, Tomita N, Nakajima H.
Probiotics and Antimicrobial Proteins, 11(1), 295-298, 2019, Refereed

Recombinant mouse calcitonin gene-related peptide secreted by Lactococcus lactis inhibits lipopolysaccharide-induced inflammatory response in macrophages
Namai F, Yamamoto Y, Sato T, Ogita T, Shimosato T.*
ANIMAL SCIENCE JOURNAL, 89(12), 1707-1711, 04 Dec. 2018

Silicosis and lung cancer: current perspectives
Sato T, Shimosato T, Klinman DM
Lung Cancer: Targets and Therapy, 26 Oct. 2018

Regulatory Role of Heme Oxygenase-1 in Silica-induced Lung Injury
Nakashima K, Sato T, Shigemori S, Shimosato T, Shinkai M, Kaneko T.
Respiratory Research, 19, 114, 01 Aug. 2018

Recombinant mouse osteocalcin secreted by Lactococcus lactis promotes glucagon-like peptide-1 induction in STC-1 cells
Namai F, Shigemori S, Sudo K, Sato T, Yamamoto Y, Nigar S, Ogita T, Shimosato T.*
CURRENT MICROBIOLOGY, 75(1), 92-98, 2018

Immune synergistic oligodeoxynucleotide from Lactobacillus rhamnosus GG enhances the immune response upon co-stimulation by bacterial and fungal cell wall components
Nigar S, Yamamoto Y, Okajima T, Sato T, Ogita T, Shimosato T*
ANIMAL SCIENCE JOURNAL, 89(10), 1504-1511, 2018

Genetically modified Lactococcus lactis producing a green fluorescence protein-bovine lactoferrin fusion protein suppresses proinflammatory cytokine expression in LPS-stimulated RAW 264.7 cells
Shigemori S, Namai F, Yamamoto Y, Nigar S, Sato T, Ogita T, Shimosato T.*
JOURNAL OF DAIRY SCIENCE, 100(9), 7007-7015, 2017

Class A CpG oligonucleotide priming rescues mice from septic shock via activation of platelet-activating factor acetylhydrolase
Yamamoto Y, Sugimura R, Watanabe T, Shigemori S, Okajima T, Nigar S, Namai F, Sato T, Ogita T, Shimosato T.*
Frontiers in immunology, 8, Article ID:1049, 2017

Synergistic oligodeoxynucleotide strongly promotes CpG-induced interleukin-6 production
Nigar S, Yamamoto Y, Okajima T, Shigemori S, Sato T, Ogita T, Shimosato T.*
BMC Immunology, 18, 44, 2017

Secretion of an immunoreactive single-chain variable fragment antibody against mouse interleukin 6 by Lactococcus lactis
Shigemori S, Ihara M, Sato T, Yamamoto Y, Nigar S, Ogita T, Shimosato T*.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 101(1), 341-349, 2017

Applications of genetically modified immunobiotics with high immunoregulatory capacity for treatment of inflammatory bowel diseases
Shigemori S, Shimosato T*.
Frontiers in immunology, 8, Article ID:22, 2017

Development of a simple IgE-independent anaphylactic model using buckwheat antigen and B-type CpG oligodeoxynucleotide from Streptococcus thermophilus
Yamamoto Y, Shigemori S, Nigar S, Oshiro K, Wang Y, Sato T,Shimosato T*.
ANIMAL SCIENCE JOURNAL, 87(5), 710-717, 2016

The use of nanoparticles to delivery immunomodulatory oligonucleotides
Klinman DM, Sato T, Shimosato T.
Wiley Interdisciplinary Reviews (WIREs): Nanomedicine and Nanobiotechnology, 8(4), 631-637, 2016

ALS-associated P56S-VAPB mutation restrains 3T3-L1 preadipocyte differentiation
Tokutake Y, Gushima K, Miyazaki H,Shimosato T, Yonekura S.
Biochemical and biophysical research communications, 460(3), 831-837, 2015

Intrapulmonary Delivery of CpG Microparticles Eliminates Lung Tumors
Sato T, Shimosato T, Ueda A, Ishigatsubo Y, Klinman DM.
Molecular cancer therapeutics, 14(10), 2198-2205, 2015

Effect of probiotics/prebiotics on cattle health and productivity
Uyeno Y, Shigemori S,Shimosato T.
Microbes and Environments, 30(2), 126-132, 2015

Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice
Shigemori S, Watanabe T, Kudoh K, Ihara M, Nigar S, Yamamoto Y, Suda Y, Sato T, Kitazawa H,Shimosato T*.
Microbial Cell Factories, 14(1), 189, 2015

Inhibitory/Suppressive Oligodeoxynucleotide Nanocapsules as Simple Oral Delivery Devices for Preventing Atopic Dermatitis in Mice
Wang Y, Yamamoto Y, Shigemori S, Watanabe T, Oshiro K, Wang X, Wang P, Sato T, Yonekura S, Tanaka S, Kitazawa H,Shimosato T*.
MOLECULAR THERAPY, 23(2), 297-309, 2015

Histological analysis of glucagon-like peptide-1 receptor expression in chicken pancreas
Watanabe T, Nishimura K, Hosaka Y,Shimosato T, Yonekura S, Suzuki D, Takemoto C, Monir M, Hiramatsu K.
CELL AND TISSUE RESEARCH, 357(1), 55-61, 2014

Oral administration of a fruiting body extract of Boletopsis leucomelas enhances intestinal IgA production in LPS-challenged mice
Shimosato T*, Kanoh J, Otani H.
Food and Agricultural Immunology, 25(4), 510-522, 2014

Generation of dipeptidyl peptidase-IV-inhibiting peptides from β-lactoglobulin secreted by Lactococcus lactis
Shigemori S, Ohshiro K, Wang P, Yamamoto Y, Wang Y, Sato T, Uyeno Y,Shimosato T*.
BioMed Research International, 393598, 2014

Suppressive oligodeoxynucleotides synergistically enhance antiproliferative effects of anticancer drugs in A549 human lung cancer cells
Takahashi R, Sato T, Klinman DM,Shimosato T, Kaneko T, Ishigatsubo Y.
INTERNATIONAL JOURNAL OF ONCOLOGY, 42(2), 429-436, 2013

Class I/II hybrid inhibitory oligodeoxynucleotide exerts Th1 and Th2 double immunosuppression
Ito Y, Shigemori S, Sato T, Shimazu T, Hatano K, Otani H, Kitazawa H,Shimosato T*.
FEBS Open Bio, 3, 41-45, 2013

Expression of the immunoreactive buckwheat major allergenic storage protein in Lactococcus lactis
Shigemori S, Yonekura S, Sato T, Otani H,Shimosato T*.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 97(8), 3603-3611, 2013

Oral administration of a casein phosphopeptide and phosphorylated dextrin preparations enhances intestinal IgA production and gene expression relating to the IgA production and calcium absorption in mice
Ikuno Y, Banno M,Shimosato T, Otani H.
Milchwissenshaft-Milk Science International, 67(3), 289-292, Jul. 2012, Refereed

Serum heme oxygenase-1 as a marker of lung function declinein patients with chronic silicosis
Sato T, Saito Y, Inoue S,Shimosato T, Takagi S, Kaneko T, Ishigatsubo Y.
Journal of Occupational and Environmental Medicine, 54(12), 1461-1466, 2012, Refereed

Expression of a biologically active GFP-αS1-casein fusion protein in Lactococcus lactis
Shigemori S, Yonekura S, Sato T, Nakanishi M, Otani H,Shimosato T*.
CURRENT MICROBIOLOGY, 64(6), 569-575, 2012

Effect of Lactobacillus pentosus ONRIC b0240 on intestinal IgA production in mice fed differing levels of protein
Shimosato T*, Tomida K, Otani H.
Journal of Agricultural and Food Chemistry, 59(6), 2646-2651, 2011

Toll-like receptor-2 activating bifidobacteria strains differentially regulate inflammatory cytokines in porcine intestinal epithelial cell culture system: finding new anti-inflammatory immunobiotics
Fujie, H, Villena J, Tohno M, Morie K, Shimazu T, Aso H, Suda Y,Shimosato T, Iwabuchi N, Xiao JZ, Yaeshima T, Iwatsuki K, Saito T, Numasaki M, Kitazawa H.
FEMS Immunology and Medical Microbiology, 63, 129-139, 2011, Refereed

Immunobiotic Lactobacillus strains augment NLRP3 expression in newborn and adult porcine gut-associated lymphoid tissues
Tohno M,Shimosato T, Aso H, Kitazawa H.
Veterinary Immunology and Immunopathology, 144(3-4), 410-416, 2011, Refereed

Immunobiotic Lactobacillus jensenii elicit anti-inflammatory activity in porcine intestinal epithelial cells by modulating negative regulators of the toll-like receptor signaling pathway.
Shimazu T, Villena J, Tohno M, Fujie H, Hosoya S,Shimosato T, Aso H, Suda Y, Kawai Y, Saito T, Alvarez S, Ikegami S, Itoh H,Kitazawa H.
Infection and Immunity, 80(1), 276-288, 2011

Immunobiotic lactic acid bacteria beneficially regulate immune response triggered by poly(I:C) in porcine intestinal epithelial cells.
Hosoya S, Villena J, Shimazu T,Tohno M, Fujie H, Chiba E,Shimosato T, Aso H,Suda Y, Kawai Y, Saito T, Alvarez S, Ikegami S, Itoh H, Kitazawa H.
Veterinary Research, 42(1), 111, 2011

Anti-allergic effects of a mixture of Saccharomyces cerevisiae and its specific goat’s milk immunoglobulin G-rich fraction on ovalbumin-sensitized BALB/c mice
Sekimura Y,Shimosato T, Otani H.
Milchwissenshaft-Milk Science International, 66(1), 7-10, 2011

Oral Administration of Phosphorylated Dextran Regulates Immune Response in Ovalbumin-Immunized Mice
Nagasawa C, Nishimura-Uemura J, Tohno M,Shimosato T, Kawai Y, Ikegami S, Oda M, Saito T, Kitazawa H.
Asian-Australasian Journal of Animal Science, 23(1), 106-115, 2010

Accelerated Wound Healing Mediated by Activation of Toll-like Receptor 9.
Sato T, Yamamoto M,Shimosato T, Klinman DM.
WoundRepair and Regeneration, 18(6), 586-593, 2010

CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9
Shimosato T*, Fujimoto M, Tohno M, Sato T, Tateo M, Otani H, Kitazawa H*.
Biochemical and biophysical research communications, 394(1), 81-86, 2010

Utilization of the porcine system to study lymphotoxin-β regulation in intestina lymphoid tissue.
Shimazu T, Tohno M, Katoh S,Shimosato T, Aso H, Kawai Y, Saito T, Kitazawa H.
Biochemical Genetics, 47(1-2), 126-136, 2009

Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ
Shimosato T*, Tohno M, SatoT, Nishiura J, Kawai Y, Saito T, Kitazawa H.
ANIMAL SCIENCE JOURNAL, 80(5), 597-604, 2009

Suppressive Oligodeoxynucleotides Inhibit Silica-induced Pulmonary Inflammation
Sato T,Shimosato T, Alvord WG, Klinman DM.
The Journal of Immunology, 180(11), 7648-7654, 2008

Immunostimulatory oligodeoxynucleotide containing TTTCGTTT motif from Lactobacillus rhamnosus GG DNA potentially suppresses OVA specific IgE production in mice.
Iliev ID, Tohno M, Kurosaki D,Shimosato T, He F, Hosoda M, Saito T, Kitazawa H.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 67(4), 370-376, 2008

Enzymatic digestion of the milk protein beta-casein releases potent chemotactic peptide(s) for monocytes and macrophages.
Kitazawa H, Yonezawa K, Tohno M,Shimosato T, Kawai Y, Saito T, Wang JM.
International Immunopharmacology, 7(9), 1150-1159, 2007

Development of molecular immunoassay system for probiotics via toll-like receptors based on food immunology.
Kitazawa H, Tohno M,Shimosato T, Saito T.
ANIMAL SCIENCE JOURNAL, 79(1), 11-21, 2007

Advanced molecular immunoassay system for immunobiotic lactic acid bacteria using a transfectant of Toll-like receptor 2.
Tohno M,Shimosato T, Kawai Y Aso H, Ikegami S, Taketomo N, Saito T, Kitazawa H.
ANIMAL SCIENCE JOURNAL, 78(2), 195-205, 2007

Toll-like receptor 2 and 9 are expressed and functional in gut-associated lymphoid tissues of presuckling newborn swine.
Tohno M,Shimosato T, Moue M, Aso H, Watanabe K, Kawai Y, Yamaguchi T, Saito T, Kitazawa H.
Veterinary Research, 37(6), 791-812, 2006

An immunostimulatory DNA sequence from a probiotic strain of Bifidobacterium longum inhibits IgE production in vitro.
Takahashi N, Kitazawa H,Shimosato T, Iwabuchi N,Xiao JZ, IwatsukiK, KokuboS Saito T.
FEMS Immunology and Medical Microbiology, 46(3), 461-469, 2006

Strong immunostimulatory activity of AT-oligodeoxynucleotide requires a six-base loop with a self-stabilized 5'-C…G-3'stem structure.
Shimosato T, Kimura T, Tohno M, Iliev ID, Katoh S, Itoh Y, Kawai Y, Sasaki T, Saito T, Kitazawa H.
CELLULAR MICROBIOLOGY, 8(3), 485-495, 2006

Toll-like receptor 9 is expressed on follicle-associated epithelia containing M cells in swine Peyer’s patches.
Shimosato T, Tohno M, KitazawaH, Katoh S, Watanabe K, KawaiY, Aso H, YamaguchiT, Saito T.
Immunology Letters, 98(1), 83-89, 2005

Augmentation of TH-1 type responseby immunoactive AT oligonucleotide from lactic acid bacteria via Toll-like receptor 9 signaling.
Shimosato T, Kitazawa H, Tohno M, Katoh S, Iliev ID, Nagasawa C, Kawai Y, Saito T.
Biochemical and biophysical research communications, 326(4), 782-787, 2005

Toll-like receptor2 is expressed on the intestinal M cells in swine.
Tohno M*,Shimosato T*, Kitazawa H, Katoh S,Iliev ID, Watanabe K, Kawai Y,Aso H, Yamaguchi T, Saito T. *Tohno M. and Shimosato T. contributed equally to this work.
Biochemicaland BiophysicalResearch Communications, 330(2), 547-554, 2005

Strong immunostimulation inmurine immune cells by Lactobacillus rhamnosus GG DNA containing novel oligodeoxynucleotide pattern.
Iliev ID, Kitazawa H,Shimosato T, Katoh S, Saito T.
CELLULAR MICROBIOLOGY, 7(3), 403-414, 2005

A swine Toll-like receptor 2-expressing transfectant as a potential primary screening system for immunobiotic microorganisms.
Tohno M, Kitazawa H,Shimosato T, Matsumoto M, Katoh S, Kawai Y,Saito T.
FEMS Immunology and Medical Microbiology, 44(3), 283-288, 2005

Development of immune assay system for both CpG and non-CpG DNA from lacticacid bacteria using a transfectant of swine Toll-like receptor 9
Shimosato T, Kitazawa H, Tohno M, Katoh S, Kawai Y, Saito T.
ANIMAL SCIENCE JOURNAL, 75, 377-382, 2004

Dextran from Leuconostoc mesenteroides augments immunostimulatory effects by the introduction of phosphate groups.
Sato T, Nishimura-Uemura J,Shimosato T, Kawai Y, Kitazawa H, Saito T.
Journal of Food Protection, 67(8), 1719-1724, 2004

Cloning and Characterization of Swine Interleukin-17, Preferentially Expressed in the Intestines.
Katoh S, Kitazawa H,Shimosato T, Tohno M, KawaiY, Saito T.
Journal of Interferon and Cytokine Research, 24(9), 553-559, 2004

Swine Toll-like receptor 9 recognizes CpG motifs of human cell stimulant.
Shimosato T, Kitazawa H, Katoh S, Tomioka Y, Karima R, Ueha S, Kawai Y, Hishinuma T, Matsushima K, Saito T.
Biochemica et Biophysica Acta, 1627(1), 56-61, 2003

Immunostimulatory oligonucleotide, CpG-like motif exists in Lactobacillus delbrueckii ssp. bulgaricus NIAI B6.
Kitazawa H, WatanabeH,Shimosato T, Kawai Y, Itoh T, Saito T.
International journal of food microbiology, 85(1-2), 11-21, 2003

機能強化乳酸菌の創製研究
生井楓，下里剛士
日本乳酸菌学会誌, 33(1), 5-11, Mar. 2022
Last, Corresponding

乳酸菌オリゴDNAを腸まで届ける経口用ナノカプセルの開発
下里剛士
JATAFFジャーナル, 6(3), 27-33, 01 Mar. 2018

ビール酵母とその牛乳抗体のマウスにおけるアレルギー軽減作用と急性毒性に関する検討
森崎健太郎，松田孝裕，須賀正喜，荻田 佑，平松浩二，下里剛士，大谷 元
北信越畜産学会報, 106, 35-47, 2013

イムノジェニクスとしての免疫刺激性DNA研究の最前線
下里剛士，北澤春樹.
北信越畜産学会報, (100), 1-9, 2010

免疫刺激性オリゴヌクレオチドの2次構造特性
下里剛士
Journal of the Faculty of Agriculture SHINSHU UNIVERSITY, 46(1-2), 1-5, 2010

Preparation of goat milk anti-Saccharomyces cerevisiae immunoglobulin G (IgG)-rich fraction and immunological functions of mice orally administered a mixture of the antigen and its specific IgG-rich fraction
Sekimura Y, Onodera N, Banno M, Hata I, HamanoK,Shimosato T, Hajime O.
Milk Science, 58(3), 119-128, 2009

イムノバイオティクス由来の新規免疫刺激性DNAモチーフの発見とその将来性
下里剛士，北澤春樹.
Milk Science, 57(3), 103-107, 2009

Swine intestinal immunity via Toll-like Receptors and its advanced application to food immunology.
Kitazawa H,Shimosato T, Tohno M, Saito T.
Journal of Integrated Field Science, 3, 9-14, 2006

豚腸管におけるToll様受容体の機能発現と食品免疫学への応用.
北澤春樹，遠野雅徳，下里剛士，齋藤忠夫.
獣医畜産新報, 59(7), 559-561, 2006

Toll様受容体9を介するイムノバイオティック乳酸菌DNAの免疫活性とその将来性．
下里剛士，北澤春樹，齋藤忠夫．
Milk Science, 54(1), 9-15, 2005

Immunostimulatory Activities of Lactic Acid Bacteria via Toll-like Receptors.
Kitazawa H,Shimosato T, TohnoM, Saito T.
Japanese Journal of Lactic Acid Bacteria, 16(1), 11-20, 2005

Introduction of Spontaneous Mutations Using Streptomycin as a Method for Lactic Acid Bacteria Breeding
Namai F, Nishiyama K, Kitazawa H, Shimosato T., 2851, 15-21
Methods in Molecular Biology, Springer Nature, 30 Aug. 2024

Encyclopedia of Food Immunology
細胞性免疫にかかわるサイトカイン[134-135頁]
Asakura Publishing Co., Ltd., 01 Nov. 2021
ISBN:978-4-254-43126-1

BIO INDUSTRY
Suguru Shigemori, Takeshi Shimosato, gmLAB as a Tool for Microbial Therapeutics: Current Perspectives
株式会社シーエムシー出版, 12 May 2020

BIO INDUSTRY
下里剛士, 機能性オリゴDNAの経口投与を可能にするDNAナノカプセルの開発[61-65頁]
株式会社シーエムシー出版, 12 Aug. 2015

PROBIOTICS: IMMUNOBIOTICS AND IMMUNOGENICS「Chapter 13, Immunogenics: immunoestimulatory oligodeoxynucleotides from probiotics」
Takeshi Shimosato, Haruki Kitazawa
CRC Press, 336-353 24 Sep. 2013
ISBN:978-1-48-220684-5

Advanced Technologies for Adjuvant Research and Development
下里剛士, 北澤春樹, プロバイオティック乳酸菌を利用した経口ワクチン・アジュバント研究の新展開[100-106頁]
株式会社シーエムシー出版, 24 Aug. 2011

The rpsL K56N mutation in Lacticaseibacillus rhamnosus GG enhances immune response via cell surface proteins
Soyolmaa Jamiyanpurev, Fu Namai, Takashi Sato, Takeshi Shimosato
ISAPP 2023 annual meeting, 27 Jun. 2023

Effect of local intratracheal therapy using particleized nintedanib in a murine model of pulmonary fibrosis
Kaho Suzuki, Fu Namai, Natsumi Nomura, Yuichi Sato, Akihiro Kotsugai, Takeshi Shimosato, Takashi Sato
American Thoracic Society 2023 International Conference, 24 May 2023

Intranasal administration of genetically modified Lactococcus lactis producing PD-L1scFv improves survival in lung cancer model mice (American Thoracic Society 2023・ATS Abstract Scholarship Award)
Natsumi Nomura, Fu Namai, Takashi Sato, Takeshi Shimosato
American Thoracic Society 2023 International Conference, 23 May 2023

Bacterial changes associated with the rpsL gene mutation in Lacticaseibacillus rhamnosus GG
Masami Tsukagoshi, Fu Namai, Suguru Shigemori, Takeshi Shimosato
The 11th Asian Conference for Lactic Acid Bacteria, 06 Nov. 2021

Lacticaseibacillus rhamnosus GGが高脂肪飼料断続給餌マウスに与える影響（若手優秀発表賞受賞）
鳥居創、重盛駿、下里剛士
酪農科学シンポジウム2021, 24 Sep. 2021

Construction of genetically modified lactic acid bacteria producing anti-IL31Ra single-chain Fragment variable (English Presentation Award)
Aito Murakami, Fu Namai, Suguru Shigemori, Ogita Tasuku, Takeshi Shimosato
The 129th Annual Meeting of Japanese Society of Animal Science, 15 Sep. 2021

Lactobacillus ingluviei C37 from broiler inhibits inflammation in LPS-stimulated mouse macrophages (English Presentation Award)
Masami Tsukagoshi, Fu Namai, Suguru Shigemori, Ogita Tasuku, Takeshi Shimosato
The 129th Annual Meeting of Japanese Society of Animal Science, 15 Sep. 2021

「乳酸菌、腸内細菌およびミルクオリゴ糖の健康機能科学」-イムノバイオティクス由来核酸成分を用いた経口用微粒子の創製と機能性食品・飼料素材への展開-[招待講演]
下里剛士
日本食品科学工学会第66回大会, 29 Aug. 2019

PD-1/PD-L1チェックポイントの阻害に働く乳酸菌組換え体の構築と肺ガンモデルマウスを用いた検証
上田麻未, 生井楓, 村上愛斗, 重盛駿, 荻田佑, 佐藤隆, 下里剛士
2019年度酪農科学シンポジウム, 23 Aug. 2019

抗CTLA-4低分子抗体を産生するLactococcus lactis組換え体の構築（若手優秀ポスター賞受賞）
村上愛斗, 生井楓, 上田麻未, 重盛駿, 荻田佑, 佐藤隆, 下里剛士
2019年度酪農科学シンポジウム, 23 Aug. 2019

Oral administration of a genetically modified osteocalcin-secreting Lactococcus lactis improves carbohydrate metabolism in high-fat diet-induced obese mice
Fu Namai, Suguru Shigemori, Tasuku Ogita, Takashi Sato, Takeshi Shimosato
13th International Scientific Conference on Probiotics, Prebiotics, Gut Mirobiota and Health, 20 Jun. 2019

Ribosome engineering enhances production of p40, a Lactobacillus rhamnosus GG-derived soluble protein, in S12 mutant strains
Shoko Kajikawa, Minori Ishida, Fu Namai, Suguru Shigemori, Tasuku Ogita, Takashi Sato, Takeshi Shimosato
13th International Scientific Conference on Probiotics, Prebiotics, Gut Mirobiota and Health, 20 Jun. 2019

Construction of a genetically modified Lactococcus lactis producing single chain Fv against vascular endothelial growth factor
Masami Tsukagoshi, Fu Namai, Kohei Watanabe, Minako Iwai, Suguru Shigemori, Tasuku Ogita, Takashi Sato, Takeshi Shimosato
13th International Scientific Conference on Probiotics, Prebiotics, Gut Mirobiota and Health, 20 Jun. 2019

Flavonifractor plautii inhibits inflammatory responses in lipopolysaccharide-stimulated RAW 264.7 cells and alleviates acute-colitis in mice
Ayane Mikami, Tasuku Ogita, Takeshi Shimosato
2018 Symposium of Korean Society for Lactic Acid Bacteria and Probiotics, Probiotics, Postbiotics, and Gut Health, 30 Nov. 2018

Flavonifractor plautii exerts Th1/Th2 immunomodulatory effects in mice
Chika Fukasawa, Tasuku Ogita, Takeshi Shimosato
2018 Symposium of Korean Society for Lactic Acid Bacteria and Probiotics, Probiotics, Postbiotics, and Gut Health, 30 Nov. 2018

Oral delivery of CpG-oligodeoxynucleotide from lactic acid bacteria ameliorates high-fat-diet-induced obesity in mice
Ryu Sugimura, Tasuku Ogita, Takeshi Shimosato
2018 Symposium of Korean Society for Lactic Acid Bacteria and Probiotics, Probiotics, Postbiotics, and Gut Health, 30 Nov. 2018

「スマートバイオデザイン：ナノからマクロスケールまでの様々な階層レベルにおけるバイオ関連機能と構造の合理的創出を目指して」-オリゴDNAの腸管送達系の構築と経口用素材への展開-[招待講演]
下里剛士
第70回日本生物工学会大会, 31 Aug. 2018

Class-B Oligodeoxynucleotide Derived from a Lactic Acid Bacterium Induces Apoptosis in Spleen Cells
Nobuhiro Ambe, Yoshinari Yamamoto, Tasuku Ogita, Takeshi Shimosato
18th AAAP Congress 2018, 01 Aug. 2018

Immunoregulatory function of Flavonifractor plautii
Tasuku Ogita, Fu Namai, Ayane Mikami, Takeshi Shimosato
18th AAAP Congress, 01 Aug. 2018

Advanced Application of Ribosome Engineering in Lactobacillus rhamnosus GG
Minori Ishida, Fu Namai, Tasuku Ogita, Takeshi Shimosato
18th AAAP Congress, 01 Aug. 2018

Recombinant mouse calcitonin gene-related peptidesecreted by Lactococcus lactis inhibits lipopolysaccharide-induced inflammatory response in macrophages
Fu Namai, Tasuku Ogita, Takeshi Shimosato
18th AAAP Congress, 01 Aug. 2018

Construction of Oligodeoxynucleotide Particles using Glycosylated Carbonate Apatite and Targeted Delivery to Macrophages
Shuichiro Yamashina, Mitsuaki Goto, Takeshi Shimosato
18th AAAP Congress, 01 Aug. 2018

Free-feeding of DNA nanocapsules containing CpG oligodeoxynucleotide from Streptococcus thermophilus
Takuma Okajima, Yoshinari Yamamoto, Tasuku Ogita, Takeshi Shimosato
International Dairy Federation (IDF) World Dairy Summit 2017, 01 Nov. 2017

Construction of genetically modified Lactococcus lactissecreting bioactive osteocalcin
Fu Namai, Suguru Shigemori, Tasuku Ogita, Takeshi Shimosato
International Dairy Federation (IDF) World Dairy Summit 2017, 01 Nov. 2017

Dose-comparison study of Lactococcus lactis producing heme oxygenase-1 for treatment of dextran sulfate sodium-induced acute colitis in mice
Suguru Shigemori, Tasuku Ogita, Takeshi Shimosato
Proceedings of the 17th AAAP Congress, 25 Aug. 2016

Immunostimulatory oligodeoxynucleotide from lactic acid bacteria promotes the anaphylaxis to ovalbumin in mice
Yoshinari Yamamoto, Takuma Okajima, Tasuku Ogita, Takeshi Shimosato
Proceedings of the 17th AAAP Congress, 25 Aug. 2016

Effect of Fishery Related Activities on the Food and Nutrition Situation of Indigenous Community in Bangladesh: A Study of Adolescent girl
Shireen Nigar, Takeshi Shimosato, Abu Torab Md. Abdur Rahim
Proceedings of the 17th AAAP Congress, 25 Aug. 2016

CpG oligodeoxynucleotide from Streptococcus thermophilus induces type 2 innate lymphoid cells（Young Scientists Award/JSAS Excellent Presentation Award受賞）
Takuma Okajima, Yoshinari Yamamoto, Tasuku Ogita, Takeshi Shimosato
Proceedings of the 17th AAAP Congress, 23 Aug. 2016

乳酸菌由来オリゴ核酸のアナフィラキシーショック亢進メカニズム（若手優秀ポスター賞受賞）
山本祥也, 岡島拓真, Nigar Shireen, 重盛駿, 下里剛士
平成27年度酪農科学シンポジウム, 25 Sep. 2015, 日本酪農科学会

ヘムオキシゲナーゼ-1を分泌する乳酸菌組換え体はマウスにおける急性大腸炎を軽減する（日本畜産学会第120回大会優秀発表賞 受賞）
重盛駿, 山本祥也, 下里剛士
日本畜産学会第120回大会, 11 Sep. 2015, 日本畜産学会

Construction of genetically modified Lactococcus lactis expressing buckwheat protein Fagag1 with strong allergenicity
Suguru Shigemori, Yoshinari Yamamoto, Kazushi Oshiro, Pengfei Wang, Yeqin Wang, Takashi Sato,Takeshi Shimosato
2015 ADSA-ASAS Joint Annual Meeting (JAM), 14 Jul. 2015

Development of an anaphylactic model of buckwheat using B-type CpG oligodeoxynucleotides from lactic acid bacteria
Yoshinari Yamamoto, Suguru Shigemori, Kazushi Oshiro, Pengfei Wang, Yeqin Wang, Takashi Sato,Takeshi Shimosato
2015 ADSA-ASAS Joint Annual Meeting (JAM), 14 Jul. 2015

Production of recombinant β-lactoglobulin in Lactococcus lactis and generation of a bioactive peptide with incretin-inactivation activity
Kazushi Oshiro, Suguru Shigemori, Yoshinari Yamamoto, Pengfei Wang, Yeqin Wang, Takashi Sato,Takeshi Shimosato
2015 ADSA-ASAS JointAnnual Meeting (JAM), 14 Jul. 2015

Strong immunostimulatory activity of oligodeoxynucleotide motifs from lactic acid bacteria
Yoshinari Yamamoto, Suguru Shigemori, Pengfei Wang, Yeqin Wang,Takeshi Shimosato
Proceedings of the 16th AAAP Congress, 12 Nov. 2014

Intracellular expression of cow’s milk allergens in genetically modified Lactococcus lactis
Suguru Shigemori, Yoshinari Yamamoto, Pengfei Wang, Yeqin Wang,Takeshi Shimosato
Proceedings of the 16th AAAP Congress, 12 Nov. 2014

インターロイキン6特異的抗体を分泌する乳酸菌組換え体の構築（若手優秀ポスター賞受賞）
重盛駿, 大城和士, Wang Pengfei, 山本祥也, Wang Yeqin, 下里剛士
平成26年度日本酪農科学シンポジウム, 12 Sep. 2014

Immunostimulatory oligodeoxynucleotide from yogurt starter bacteria Streptococcus thermophilus, strongly induces interleukin 33
Yusuke Ito, Suguru Shigemori, Hajime Otani, Haruki Kitazawa,Takeshi Shimosato
International Dairy Federation, World Dairy Summit 2013, 28 Oct. 2013, International Dairy Federation

Expression of immunoreactive αS1-casein in Lactococcus lactis as a treatment strategy for milk allergy
Suguru Shigemori, Hajime Otani,Takeshi Shimosato
International Dairy Federation, World Dairy Summit 2013, 28 Oct. 2013, International Dairy Federation

Suppressive Oligodeoxynucleotide Synergistically Enhances The Antiproliferative Effect Of Anti-cancer Drug In Human Lung Cancer Cells
Takahashi R, Sato T, Miyazawa N, Klinman DM,Shimosato T, Hayashi M, Yamamoto M, Tomaru K, Tsukahara T, Kaneko T, Ishigatsubo Y.
American Thoracic Society Annual Meeting 2011, 2011

Toll-like receptor 4recognizes extracellular polysaccharide from Lactococcus lactis subsp. cremoris
Tohno M,Shimosato T, Aso H, Kitazawa H.
4th congress of european microbiologists FEMS, 2011

CpG oligodeoxynucleotides promote wound healing in airway epithelial cells
Sato T, Miyazawa N, KlinmanDM,Shimosato T, Takahashi R, Tsukahara T, Hayashi M, Yamamoto M, Tomaru K, Kaneko T, Ishigatsubo Y.
American Thoracic Society Annual Meeting 2011, 2011

Immunoregulation of immunobiotic lactic acid bacterial DNA and their advanced application to Food Science
Takeshi Shimosato
Shinshu University International Symposium 2010 in Ina, Sustainable Agriculture and Environment: Asian Network II, proceedings, 2010

The novel immunostimulatory activities of CpG oligodeoxynucleotides from Streptococcus thermophilus
Shimosato T, Fujimoto M, Tohno M, Sato T, Otani H, Kitazawa H.
ADSA-PSA-AMPA-CSAS-ASAS Joint Annual Meeting (JAM), 2010

Accelerated wound healing in mice by local administration of sustained-release CpG oligodeoxynucleotide.
Sato T,Shimosato T, Klinman DM.
97th AAI Annual Meeting, 2010

Effect of immunobiotics on the immune performance and productivity of pigs
SudaY, TakahashiY, Tohno M, Villena Julio, Hosoya S, Fujie H,Shimosato T, Kobashi J, Ishida M, Aso H, Kawai Y, Saito T, Makino S, Ikegami S, Kitazawa H.
International Scientific Conference on Probiotics and Prebiotics - IPC2010, 2010

Evaluation of Anti-Inflammatory Immunobiotics in Porcine Intesinal Epithelial Cells
Kitazawa H, Shimazu T, Tohno M, Villena J, Hosoya S, Fujie H, Suda Y,Shimosato T, Aso H, Makino S, Ikegami S, Kawai Y, Saito T.
International ScientificConference on Probiotics andPrebiotics - IPC2010, 2010

CpG oligodeoxynucleotide incorporated basement membrane extract facilitate wound repair in mice
Sato T,Shimosato T, Klinman DM
96th AAI Annual Meeting, 2009

CpG oligodeoxynucleotide from Streptococcus thermophilus lacZ strongly induces the expression of interleukin-33 in murine immune cells
Shimosato T, Tohno M, Sato T, Tateo M, Otani H, Kitazawa H
The 9th World Congress on Inflammation, 2009

REGULATION OF INFLAMMATORY RESPONSE BY IMMUNOBIOTICS IN SWINE INTESTINAL EPITHELIAL CELLS VIA MKP-1
ShimazuT, Tohno M, Hosoya S, Fujie H,Shimosato T, Aso H, Suda Y, KawaiY, Saito T, Kitazawa H.
The 9th World Congress on Inflammation, 2009

CpG oligodeoxynucleotide from Streptococcus thermophilus regulates anti-inflammatory responses
Shimosato T, Tohno M, Sato T, Kitazawa H
ADSA-CSAS-ASAS 2009 Joint Annual Meeting, 2009

「イムノバイオティクス由来の新規免疫刺激性DNAモチーフの発見とその将来性」[招待講演]
下里剛士
平成20年度酪農科学シンポジウム, 29 Aug. 2008

Immuno-stimulatory AT oligodeoxynucleotide from Lactobacillus gasseri requires a specific self-stabilized structure
Shimosato T, Tohno M, Sato T, Kawai Y, Saito T, Kitazawa H
ADSA-ASAS 2008 Joint Annual Meeting, 2008

Suppressive oligodeoxynucleotides improve outcome in murine silicosis
SatoT,Shimosato T, Klinman DM
American Thoracic Society Annual Meeting 2008, 2008

Immunobiotic lactic acid bacteria induce immune responses in immature gut-associatedlymphoid tissues via Toll-likereceptors 2 and 9
Kitazawa H, Tohno M,Shimosato T, Aso H, Kawai, Y, Saito T.
ADSA-ASAS 2006 Joint Annual Meeting, 2006

Development of a novel immunoassay system for immunobiotics that modulate intestinal immunity through Toll-likereceptor 2
Tohno M,Shimosato T, Kawai, Y, Saito T. Kitazawa H,
ADSA-ASAS 2006 Joint Annual Meeting, 2006

Immune responses of Immunobiotics and Immunogenics via Toll-like receptors and their advancedapplication to Food immunology
Kitazawa H,Shimosato T, Tohno M, Saito T
2nd International Bio-microcosmos Workshop, 2006

Swine intestinal immunity via Toll-like receptors and its advanced application to Food immunology
Kitazawa H,Shimosato T, Tohno M, Saito T
International Symposium on Recent Advances in Animal Science, 2005

Immunostimulatory activities of a novel AT oligonucleotide from "Immunobiotic" Lactobacillus gasseri on swine Peyer's patch cells
Kitazawa H,Shimosato T, Katoh S, Tohno M, Kawai, Y, Saito T.
Journal of Dairy Science 87 417, 2004, ADSA-ASAS 2004 Joint Annual Meeting

AT oligonucleotide from"Immunobiotic"Lactobacillus gasseri augments immune responses via Toll-like receptor 9 signaling
Shimosato T, Kitazawa H, Tohno M, Katoh S, Kawai, Y, Saito T.
ADSA-ASAS 2004 Joint Annual Meeting, 2004

動物生命科学
Shinshu University

動物資源生命科学概論
Shinshu University

食と微生物
Shinshu University

畜産物利用学
Shinshu University

動物資源化学実験
Shinshu University

科学英語I
Shinshu University

細胞システム科学特論
Shinshu University

先端生命科学特論／生命産業科学特論
Shinshu University

分子生命工学特論
Shinshu University

先鋭領域融合研究群最先端研究特講
Shinshu University

Advanced Study for Life Science
Shinshu University

Animal Science
Shinshu University

01 Apr. 2023
JAPANESE SOCIETY FOR BACTERIOLOGY

2001
Japanese Society of Animal Science

2001
Japan Society for Biosicence, Biotechnology and Agrochemistry

2005
Japanese Association for Food Immunology

2002
Japanese Dairy Science Association

2003
Japan Society for Lactic Acid Bacteria

01 Apr. 2020
中部乳酸菌研究会

2008
北信越畜産学会

2016
日本栄養・食糧学会

経口用乳酸菌オリゴDNA微粒子の最適化と腸管上皮を起点とする免疫制御機構の解明
科学研究費補助金, 基盤研究B
2020 - 2023

国立研究開発法人新エネルギー・産業技術総合開発機構（NEDO）官民による若手研究者発掘支援事業・マッチングサポートフェーズ（代表）
2020 - 2022

スマート乳酸菌の創製研究
科学研究費補助金, 挑戦的研究（萌芽）
2020 - 2021

免疫チェックポイント阻害乳酸菌による肺癌発癌予防・進展予防効果の検証
科学研究費補助金, 国際共同研究加速基金 国際共同研究強化B
2019 - 2022

吸入療法イノベーションの実現：高分子・抗体医薬の経気道投与による肺癌治療戦略
科学研究費補助金, 挑戦的研究（萌芽）
2018 - 2019

乳酸菌オリゴDNAを有効成分とする経口用ナノカプセルを用いた免疫調節機構の解明
科学研究費補助金, 基盤研究B
2017 - 2020

国立研究開発法人日本医療研究開発機構（AMED）創薬基盤推進研究事業（分担）
2017 - 2019

ナノ粒子化免疫調節剤の呼吸器疾患への治療応用の研究
科学研究費補助金, 基盤研究C
2016 - 2018

研究成果最適展開支援プログラム A-STEP「フィージビリティスタディ（ＦＳ）・ステージ」探索タイプ（代表）
2014 - 2015

乳酸菌DNAのナノカプセル体を用いた新規食品および飼料素材開発のための基盤構築
科学研究費補助金, 基盤研究C
01 Apr. 2012 - 31 Mar. 2015

研究成果最適展開支援プログラム A-STEP「フィージビリティスタディ（ＦＳ）・ステージ」探索タイプ（代表）
2011 - 2012

プロバイオティック乳酸菌DNAの機能性食品および飼料素材としての利用法の開発
科学研究費補助金, 若手研究B
01 Apr. 2010 - 31 Mar. 2012

ナノ粒子を用いた抗アレルギーDNAワクチンの腸管粘膜系における免疫応答機構の解明
科学研究費補助金, 若手研究B
01 Apr. 2008 - 31 Mar. 2010

Functional analysis of oligodeoxynucleotides from bacteria

Development of mucosal vaccineusing lactic acid bacteria

Research on functional enhancement of lactic acid bacteria

US8163506: USE OF TOLL-LIKE RECEPTOR-EXPRESSING CELLS, US8163506
Tadao Saito, Takeshi Shimosato,Haruki Kitazawa

4562123: Toll様レセプター強制発現細胞の利用, 特許4562123
齋藤忠夫, 下里剛士, 遠野雅徳, 北澤春樹

5403457: ATオリゴヌクレオチドを有効成分とする免疫応答増強性薬剤及び食品組成物, 5403457
北澤春樹, 齋藤忠夫, 下里剛士, 佐々木隆, 伊藤喜之

「食」と「健康」ラボ研究会第6回シンポジウム
lecturer
長野県, 長野県工業技術センター, 03 Mar. 2021

令和元年度 第三回信州機能性食品開発研究会
lecturer
21 Aug. 2019

平成30年度 第三回信州機能性食品開発研究会
lecturer
18 Dec. 2018

安曇野市市民大学講座
lecturer
安曇野市, 豊科交流学習センター「きぼう」, 23 Aug. 2018

第8回 化粧品開発展 -COSME Tech 2018-
lecturer
幕張メッセ, 26 Jan. 2018

信州コロイド＆界面科学研究会
lecturer
信州大学工学部, 27 Oct. 2017

アグリビジネス創出フェア2017
lecturer
東京ビックサイト, 04 Oct. 2017

第14回日本農学進歩賞受賞講演会
lecturer
公益財団法人農学会, 東京大学弥生講堂 一条ホール, 27 Nov. 2015

第二回信大見本市ミニプレゼンテーション「“食べる”機能性DNAの開発」
lecturer
松本市浅間温泉文化センター, 04 Mar. 2015

健康食品管理士会長野県分科会講演会
lecturer
健康食品管理士会, 信州大学医学部保健学科, 04 Sep. 2011

平成２２年度「信州大学医農連携交流会」
lecturer
信州機能性食品研究会, 長野県松本勤労者福祉センター, 20 Jan. 2011

2020, 1, 2, モンゴル（2）

2019, 2, 2, ベルギー（1），モンゴル（1）