Shimosato, Takeshi | Shinshu University Researcher Directory

Academic Organization	Academic Assembly　School of Science and Technology　Institute of Agriculture	TEL
Education and Research Organization	Interdisciplinary Cluster for Cutting Edge Research, Institute for Biomedical Sciences	FAX
Position	Professor	Mail Address
Address	8304 Minamiminowa Kamiina Nagano 399-4598 Japan	Web site	http://www.shinshu-u.ac.jp/faculty/agriculture/lab/shimolab/

Profile

Research Group: Institute for Biomedical Sciences

Research Field: Dairy Science
Keywords:Biochemistry and Technology of Animal Products , Dairy Science

Current Subject: Research on functional enhancement of lactic acid bacteria
Keywords:Research on lactic acid bacteria
Functional analysis of oligodeoxynucleotides from bacteria
Keywords:Food immunology , oligodeoxynucleotide
Development of mucosal vaccineusing lactic acid bacteria
Keywords:mucosal vaccine , Lactic acid bacteria

Academic Societies: Academic Societies
Japanese Society for Bacteriology
中部乳酸菌研究会
日本栄養・食糧学会
北信越畜産学会
Japanese Association for Food Immunology
Japan Society for Lactic Acid Bacteria
Japanese Dairy Science Association
Japanese Society of Animal Science
Japan Society for Biosicence, Biotechnology and Agrochemistry

Committee of Academic Societies
2020- , 酪農科学シンポジウム2020 , 大会長
2020- , 北信越畜産学会 , 評議員
2019- , 日本酪農科学会 , 監事
2021-2024 , Japan Society for Lactic Acid Bacteria , Director
2017-2019 , 北信越畜産学会 , 監事
2016-2021 , Japan Society for Lactic Acid Bacteria , Councilor

Academic Background: Graduate School
Tohoku University , (Division of Bioscience and Biotechnology for Future Bioindustries , Graduate School ofAgricultural Science) , 2006
Tohoku University , (Division of Biological Resource Science , Graduate School of Agricultural Science) , 2003

College
Tohoku University , (Faculty of Agriculture) , 2001

Degree
Ph.D. , Tohoku University

Awards: 2017 , Award for Young Agricultural Researchers
2015 , Japan Prize in Agricultural Science, Achievement Award for Young Scientists
2011 , Animal Science Journal Excellent Paper Award 2011
2011 , Japanese Society of Animal Science Young Investigator's Award
2008 , Animal Science Journal Excellent Paper Award 2008
2006 , Dean’s Award of Graduate School of Agricultural Science of Tohoku University
2006 , President’s Award of Tohoku University
2005 , Award for Young Scientist from The Japanese Society of Dairy and Foodscience
2004 , The Best Presentation Award for the 103rd annual meeting of Japanese Society of Animal Science

Research Career: Research Career
2019- , Professor, Faculty of Agriculture, Shinshu University
2019- , Department Head, Department of Biomolecular Innovation, Institute for Biomedical Sciences, Shinshu University
2016-2019 , Director, Research Center for Fungal and Microbial Dynamism, Shinshu University
2012-2019 , Associate Professor, Faculty of Agriculture, Shinshu University
2007-2012 , Assistant Professor, Fiber-Nanotech Young Researcher Empowerment Center, Shinshu University
2007-2007 , Japan Society for Promotion of Science (JSPS) fellow for Research Abroad, National Cancer Institute (NCI) at Frederick
2006-2007 , Japan Society for Promotion of Science (JSPS) fellow for Research Abroad, Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration

Research

Books, Articles, etc.: Books
細胞性免疫にかかわるサイトカイン[134-135頁], Encyclopedia of Food Immunology
Asakura Publishing Co., Ltd. 2021(Nov. 01)

gmLAB as a Tool for Microbial Therapeutics: Current Perspectives, BIO INDUSTRY
株式会社シーエムシー出版 2020(May 12)
Author:Suguru Shigemori, Takeshi Shimosato

機能性オリゴDNAの経口投与を可能にするDNAナノカプセルの開発[61-65頁], BIO INDUSTRY
株式会社シーエムシー出版 2015(Aug. 12)
Author:下里剛士

PROBIOTICS: IMMUNOBIOTICS AND IMMUNOGENICS「Chapter 13, Immunogenics: immunoestimulatory oligodeoxynucleotides from probiotics」, 336-353
CRC Press 2013(Sep. 24)
Author:Takeshi Shimosato, Haruki Kitazawa

プロバイオティック乳酸菌を利用した経口ワクチン・アジュバント研究の新展開[100-106頁], Advanced Technologies for Adjuvant Research and Development
株式会社シーエムシー出版 2011(Aug. 24)
Author:下里剛士, 北澤春樹

Articles
Oral administration of Brevibacterium linens from washed cheese increases short-chain fatty acid-producing bacteria and lactobacilli in the gut microbiota of mice
Animal Science Journal 2024
Author:Murakami A, Toyomoto K, Namai F, Sato T, Fujii T, Tochio T, Shimosato T.

Myogenetic oligodeoxynucleotide induces myocardial differentiation of murine pluripotent stem cells.
Int J Mol Sci,24(18):14380 2023
Author:Ishioka M, Nihashi Y, Sunagawa Y, Umezawa K, Shimosato T, Kagami H, Morimoto T, Takaya T.

Development of fluorescence-labeled antibody for immune checkpoint inhibitor using engineered probiotics
AMB Express,13(4) 2023
Author:Namai F, Sumiya S, Nomura N, Sato T, Shimosato T.*

Development of a single-chain fragment variable that binds to the SARS-CoV-2 spike protein produced by genetically modified lactic acid bacteria
Molecular Biotechnology 2023
Author:Oshima S, Namai F, Sato T, Shimosato T..*

Assessment of lactic acid bacteria isolated from the chicken digestive tract for potential use as poultry probiotics
Animal Bioscience 2023
Author:Sirisopapong S, Shimosato T., Okrathok S, Khempaka S.

Identification of a novel osteogenetic oligodeoxynucleotide (osteoDN) that promotes osteoblast differentiation in a TLR9-independent manner.
Nanomaterials,12(10):1680 2022(May 14)
Author:Nihashi Y, Miyoshi M, Umezawa K, Shimosato T, Takaya T.

Myogenetic oligodeoxynucleotides as anti-nucleolin aptamers inhibit the growth of embryonal rhabdomyosarcoma cells.
Biomedicines,10(11):2691 2022
Author:Nohira N, Shinji S, Nakamura S, Nihashi Y, Shimosato T, Takaya T.

Myogenetic oligodeoxynucleotide restores differentiation and reverses inflammation of myoblasts aggravated by cancer-conditioned medium
Muscles,1(2):111-120 2022
Author:Nihashi Y, Yamamoto M, Shimosato T, Takaya T.

Free feeding of CpG-oligodeoxynucleotide particles prophylactically attenuates allergic airway inflammation and hyperresponsiveness in mice
Frontiers in Immunology,12:738041 2021(Nov. 19)
Author:Okajima, T., Shigemori S*, Namai F, Ogita T, Sato T, Shimosato T.*

A soybean resistant protein-containing diet increased the production of Reg3g through the regulation of the gut microbiota and enhanced the intestinal barrier function in mice
Frontiers in Nutrition,8:701466 2021(Aug. 19)
Author:Ogita T, Namai F, Mikami A, Ishiguro T, Umezawa K, Uyeno Y, Shimosato T.*

Myogenetic oligodeoxynucleotide complexed with berberine promotes differentiation of chicken myoblasts.
Animal Science Journal,92(1):e13597 2021(Jul. 25)
Author:Nihashi Y, Shinji S, Umezawa K, Shimosato T, Ono T, Kagami H, Takaya T

Myogenetic oligodeoxynucleotide (myoDN) recovers the differentiation of skeletal muscle myoblasts deteriorated by diabetes mellitus.
Frontiers in Physiology,12:679152 2021(May 24)
Author:Nakamura S, Yonekura S, Shimosato T, Takaya T.

Identification of the myogenetic oligodeoxynucleotides (myoDNs) that promote differentiation of skeletal muscle myoblasts by targeting nucleolin
Frontiers in Cell and Developmental Biology,6:616706 2021(Jan. 11)
Author:Shinji S, Umezawa K, Nihashi Y, Nakamura S, Shimosato T, Takaya T.

Oral administration of Flavonifractor plautii, a bacteria increased with green tea consumption, promotes recovery from acute colitis in mice via suppression of IL-17
Frontiers in Nutrition,7:610946 2021
Author:Mikami A, Ogita T, Namai F, Shigemori S, Sato T, Shimosato T.*

Nasally Administered Lactococcus lactis Secreting Heme Oxygenase-1 Attenuates Murine Emphysema
Antioxidants,9(1049) 2020(Oct. 27)
Author:Yumoto K, Sato T*, Nakashima K, Namai F, Shigemori S, Shimosato T, Kaneko T.

Ribosome-engineered Lacticaseibacillus rhamnosus GG exhibits cell surface GAPDH accumulation and enhanced adhesion to human colonic mucin
Applied and Environmental Microbiology,86(20):e01448-20 2020(Oct. 01)
Author:Ishida M, Namai F, Shigemori S, Kajikawa S, Tsukagoshi M, Sato T, Ogita T, Shimosato T.*

Oral priming with oligodeoxynucleotide particles from Lactobacillus rhamnosus GG attenuates symptoms of dextran sodium sulfate-induced acute colitis in mice
Animal Science Journal,91(1):e13468 2020(Oct.)
Author:Shigemori S, Namai F, Ogita T, Sato T, Shimosato T.*

Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice
Experimental & Molecular Medicine,52(9):1627-1636 2020(Sep. 28)
Author:Namai F, Shigemori S, Ogita T, Sato T, Shimosato T.*

Construction of genetically modified Lactococcus lactis producing anti-human-CTLA-4 single-chain fragment variable
Molecular Biotechnology,62(11):572-579 2020(Sep. 23)
Author:Namai F, Murakami A, Ueda A, Tsukagoshi M, Shigemori S, Ogita T, Sato T, Shimosato T.*

Editorial: Nutrition, Immunity and Viral Infections
Frontiers in Nutrition,7(125) 2020(Sep. 08)
Author:Villena J*, Shimosato T, Vizoso-Pinto MG, Kitazawa H.*

Oral administration of Flavonifractor plautii attenuates inflammatory responses in obese adipose tissue
Molecular Biology Reports,47(9):6717-6725 2020(Sep.)
Author:Mikami A, Ogita T, Namai F, Shigemori S, Sato T, Shimosato T.*

Construction of genetically modified Lactococcus lactis that produces bioactive anti-interleukin-4 single-chain fragment variable
Molecular Biology Reports,47(9):7039-7047 2020(Sep.)
Author:Namai F, Shigemori S, Ogita T, Sato T, Shimosato T.*

Lactobacillus ingluviei C37 from chicken inhibits inflammation in LPS-stimulated mouse macrophages
Animal Science Journal,91:e13436 2020(Aug. 30)
Author:Tsukagoshi M, Sirisopapong M, Namai F, Ishida M, Okrathok S, Shigemori S, Ogita T, Sato T, Khempaka S*, Shimosato T.*

Oral administration of Flavonifractor plautii strongly suppresses Th2 immune responses in mice
Frontiers in Immunology,11:379 2020(Feb. 28)
Author:Ogita T, Yamamoto Y, Mikami A, Shigemori S, Sato T, Shimosato T.*

Cooperation of Oligodeoxynucleotides and Synthetic Molecules as Enhanced Immune Modulators
Frontiers in Nutrition,6:140 2019(Aug. 27)
Author:Nigar S, Shimosato T.*

Septicemia fromLactobacillus rhamnosus GG, from a Probiotic Enriched Yogurt, in a Patient with Autologous Stem Cell Transplantation
Probiotics and Antimicrobial Proteins,11(1):295-298 2019
Author:Koyama S, Fujita H, Shimosato T, Kamijo A, Ishiyama Y, Yamamoto E, Ishii Y, Hattori Y, Hagiwara M, Yamazaki E, Tomita N, Nakajima H.

Recombinant mouse calcitonin gene-related peptide secreted by Lactococcus lactis inhibits lipopolysaccharide-induced inflammatory response in macrophages
Animal Science Journal,89(12):1707-1711 2018(Dec. 04)
Author:Namai F, Yamamoto Y, Sato T, Ogita T, Shimosato T.*

Silicosis and lung cancer: current perspectives
Lung Cancer: Targets and Therapy 2018(Oct. 26)
Author:Sato T, Shimosato T, Klinman DM

Regulatory Role of Heme Oxygenase-1 in Silica-induced Lung Injury
Respiratory Research,19:114 2018(Aug. 01)
Author:Nakashima K, Sato T, Shigemori S, Shimosato T, Shinkai M, Kaneko T.

Immune synergistic oligodeoxynucleotide from Lactobacillus rhamnosus GG enhances the immune response upon co-stimulation by bacterial and fungal cell wall components
Animal Science Journal,89(10):1504-1511 2018
Author:Nigar S, Yamamoto Y, Okajima T, Sato T, Ogita T, Shimosato T*

Recombinant mouse osteocalcin secreted by Lactococcus lactis promotes glucagon-like peptide-1 induction in STC-1 cells
Current Microbiology,75(1):92-98 2018
Author:Namai F, Shigemori S, Sudo K, Sato T, Yamamoto Y, Nigar S, Ogita T, Shimosato T.*

Synergistic oligodeoxynucleotide strongly promotes CpG-induced interleukin-6 production
BMC Immunology,18:44 2017
Author:Nigar S, Yamamoto Y, Okajima T, Shigemori S, Sato T, Ogita T, Shimosato T.*

Class A CpG oligonucleotide priming rescues mice from septic shock via activation of platelet-activating factor acetylhydrolase
Frontiers in Immunology,8:Article ID:1049 2017
Author:Yamamoto Y, Sugimura R, Watanabe T, Shigemori S, Okajima T, Nigar S, Namai F, Sato T, Ogita T, Shimosato T.*

Genetically modified Lactococcus lactis producing a green fluorescence protein-bovine lactoferrin fusion protein suppresses proinflammatory cytokine expression in LPS-stimulated RAW 264.7 cells
Journal of Dairy Science,100(9):7007-7015 2017
Author:Shigemori S, Namai F, Yamamoto Y, Nigar S, Sato T, Ogita T, Shimosato T.*

Applications of genetically modified immunobiotics with high immunoregulatory capacity for treatment of inflammatory bowel diseases
Frontiers in Immunology,8:Article ID:22 2017
Author:Shigemori S, Shimosato T*.

Secretion of an immunoreactive single-chain variable fragment antibody against mouse interleukin 6 by Lactococcus lactis
Applied Microbiology and Biotechnology,101(1):341-349 2017
Author:Shigemori S, Ihara M, Sato T, Yamamoto Y, Nigar S, Ogita T, Shimosato T*.

The use of nanoparticles to delivery immunomodulatory oligonucleotides
Wiley Interdisciplinary Reviews (WIREs): Nanomedicine and Nanobiotechnology,8(4):631-637 2016
Author:Klinman DM, Sato T, Shimosato T.

Development of a simple IgE-independent anaphylactic model using buckwheat antigen and B-type CpG oligodeoxynucleotide from Streptococcus thermophilus
Animal Science Journal,87(5):710-717 2016
Author:Yamamoto Y, Shigemori S, Nigar S, Oshiro K, Wang Y, Sato T,Shimosato T*.

Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice
Microbial Cell Factories,14(1):189 2015
Author:Shigemori S, Watanabe T, Kudoh K, Ihara M, Nigar S, Yamamoto Y, Suda Y, Sato T, Kitazawa H,Shimosato T*.

Intrapulmonary Delivery of CpG Microparticles Eliminates Lung Tumors
Molecular Cancer Therapeutics,14(10):2198-2205 2015
Author:Sato T, Shimosato T, Ueda A, Ishigatsubo Y, Klinman DM.

ALS-associated P56S-VAPB mutation restrains 3T3-L1 preadipocyte differentiation
Biochemical and Biophysical Research Communications,460(3):831-837 2015
Author:Tokutake Y, Gushima K, Miyazaki H,Shimosato T, Yonekura S.

Effect of probiotics/prebiotics on cattle health and productivity
Microbes and Environments,30(2):126-132 2015
Author:Uyeno Y, Shigemori S,Shimosato T.

Inhibitory/Suppressive oligodeoxynucleotide nanocapsules as simple oral delivery devices for preventing atopic dermatitis in mice
Molecular Therapy,23(2):297-309 2015
Author:Wang Y, Yamamoto Y, Shigemori S, Watanabe T, Oshiro K, Wang X, Wang P, Sato T, Yonekura S, Tanaka S, Kitazawa H,Shimosato T*.

Generation of dipeptidyl peptidase-IV-inhibiting peptides from β-lactoglobulin secreted by Lactococcus lactis
BioMed Research International,:393598 2014
Author:Shigemori S, Ohshiro K, Wang P, Yamamoto Y, Wang Y, Sato T, Uyeno Y,Shimosato T*.

Histological analysis of glucagon-like peptide-1 receptor expression in chicken pancreas
Cell and Tissue Research,357(1):55-61 2014
Author:Watanabe T, Nishimura K, Hosaka Y,Shimosato T, Yonekura S, Suzuki D, Takemoto C, Monir M, Hiramatsu K.

Oral administration of a fruiting body extract of Boletopsis leucomelas enhances intestinal IgA production in LPS-challenged mice
Food and Agricultural Immunology,25(4):510-522 2014
Author:Shimosato T*, Kanoh J, Otani H.

Suppressive oligodeoxynucleotides synergistically enhance antiproliferative effects of anticancer drugs in A549 human lung cancer cells
International Journal of Oncology,42(2):429-436 2013
Author:Takahashi R, Sato T, Klinman DM,Shimosato T, Kaneko T, Ishigatsubo Y.

Expression of the immunoreactive buckwheat major allergenic storage protein in Lactococcus lactis
Applied Microbiology and Biotechnology,97(8):3603-3611 2013
Author:Shigemori S, Yonekura S, Sato T, Otani H,Shimosato T*.

Class I/II hybrid inhibitory oligodeoxynucleotide exerts Th1 and Th2 double immunosuppression
FEBS Open Bio,3:41-45 2013
Author:Ito Y, Shigemori S, Sato T, Shimazu T, Hatano K, Otani H, Kitazawa H,Shimosato T*.

Oral administration of a casein phosphopeptide and phosphorylated dextrin preparations enhances intestinal IgA production and gene expression relating to the IgA production and calcium absorption in mice
Milchwissenshaft-Milk Science International,67(3):289-292 2012(Jul.)
Author:Ikuno Y, Banno M,Shimosato T, Otani H.

Expression of a biologically active GFP-αS1-casein fusion protein in Lactococcus lactis
Current Microbiology,64(6):569-575 2012
Author:Shigemori S, Yonekura S, Sato T, Nakanishi M, Otani H,Shimosato T*.

Serum heme oxygenase-1 as a marker of lung function declinein patients with chronic silicosis
Journal of Occupational and Environmental Medicine,54(12):1461-1466 2012
Author:Sato T, Saito Y, Inoue S,Shimosato T, Takagi S, Kaneko T, Ishigatsubo Y.

Immunobiotic lactic acid bacteria beneficially regulate immune response triggered by poly(I:C) in porcine intestinal epithelial cells.
Veterinary Research,42(1):111 2011
Author:Hosoya S, Villena J, Shimazu T,Tohno M, Fujie H, Chiba E,Shimosato T, Aso H,Suda Y, Kawai Y, Saito T, Alvarez S, Ikegami S, Itoh H, Kitazawa H.

Immunobiotic Lactobacillus jensenii elicit anti-inflammatory activity in porcine intestinal epithelial cells by modulating negative regulators of the toll-like receptor signaling pathway.
Infection and Immunity,80(1):276-288 2011
Author:Shimazu T, Villena J, Tohno M, Fujie H, Hosoya S,Shimosato T, Aso H, Suda Y, Kawai Y, Saito T, Alvarez S, Ikegami S, Itoh H,Kitazawa H.

Immunobiotic Lactobacillus strains augment NLRP3 expression in newborn and adult porcine gut-associated lymphoid tissues
Veterinary Immunology and Immunopathology,144(3-4):410-416 2011
Author:Tohno M,Shimosato T, Aso H, Kitazawa H.

Toll-like receptor-2 activating bifidobacteria strains differentially regulate inflammatory cytokines in porcine intestinal epithelial cell culture system: finding new anti-inflammatory immunobiotics
FEMS Immunology and Medical Microbiology,63:129-139 2011
Author:Fujie, H, Villena J, Tohno M, Morie K, Shimazu T, Aso H, Suda Y,Shimosato T, Iwabuchi N, Xiao JZ, Yaeshima T, Iwatsuki K, Saito T, Numasaki M, Kitazawa H.

Effect of Lactobacillus pentosus ONRIC b0240 on intestinal IgA production in mice fed differing levels of protein
Journal of Agricultural and Food Chemistry,59(6):2646-2651 2011
Author:Shimosato T*, Tomida K, Otani H.

Anti-allergic effects of a mixture of Saccharomyces cerevisiae and its specific goat’s milk immunoglobulin G-rich fraction on ovalbumin-sensitized BALB/c mice
Milchwissenshaft-Milk Science International,66(1):7-10 2011
Author:Sekimura Y,Shimosato T, Otani H.

Accelerated Wound Healing Mediated by Activation of Toll-like Receptor 9.
WoundRepair and Regeneration,18(6):586-593 2010
Author:Sato T, Yamamoto M,Shimosato T, Klinman DM.

Oral Administration of Phosphorylated Dextran Regulates Immune Response in Ovalbumin-Immunized Mice
Asian-Australasian Journal of Animal Science,23(1):106-115 2010
Author:Nagasawa C, Nishimura-Uemura J, Tohno M,Shimosato T, Kawai Y, Ikegami S, Oda M, Saito T, Kitazawa H.

CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9
Biochemical and Biophysical Research Communications,394(1):81-86 2010
Author:Shimosato T*, Fujimoto M, Tohno M, Sato T, Tateo M, Otani H, Kitazawa H*.

Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ
Animal Science Journal,80(5):597-604 2009
Author:Shimosato T*, Tohno M, SatoT, Nishiura J, Kawai Y, Saito T, Kitazawa H.

Utilization of the porcine system to study lymphotoxin-β regulation in intestina lymphoid tissue.
Biochemical Genetics,47(1-2):126-136 2009
Author:Shimazu T, Tohno M, Katoh S,Shimosato T, Aso H, Kawai Y, Saito T, Kitazawa H.

Immunostimulatory oligodeoxynucleotide containing TTTCGTTT motif from Lactobacillus rhamnosus GG DNA potentially suppresses OVA specific IgE production in mice.
Scandinavian Journal of Immunology,67(4):370-376 2008
Author:Iliev ID, Tohno M, Kurosaki D,Shimosato T, He F, Hosoda M, Saito T, Kitazawa H.

Suppressive Oligodeoxynucleotides Inhibit Silica-induced Pulmonary Inflammation
The Journal of Immunology,180(11):7648-7654 2008
Author:Sato T,Shimosato T, Alvord WG, Klinman DM.

Advanced molecular immunoassay system for immunobiotic lactic acid bacteria using a transfectant of Toll-like receptor 2.
Animal Science Journal,78(2):195-205 2007
Author:Tohno M,Shimosato T, Kawai Y Aso H, Ikegami S, Taketomo N, Saito T, Kitazawa H.

Development of molecular immunoassay system for probiotics via toll-like receptors based on food immunology.
Animal Science Journal,79(1):11-21 2007
Author:Kitazawa H, Tohno M,Shimosato T, Saito T.

Enzymatic digestion of the milk protein beta-casein releases potent chemotactic peptide(s) for monocytes and macrophages.
International Immunopharmacology,7(9):1150-1159 2007
Author:Kitazawa H, Yonezawa K, Tohno M,Shimosato T, Kawai Y, Saito T, Wang JM.

Strong immunostimulatory activity of AT-oligodeoxynucleotide requires a six-base loop with a self-stabilized 5'-C…G-3'stem structure.
Cellular Microbiology,8(3):485-495 2006
Author:Shimosato T, Kimura T, Tohno M, Iliev ID, Katoh S, Itoh Y, Kawai Y, Sasaki T, Saito T, Kitazawa H.

An immunostimulatory DNA sequence from a probiotic strain of Bifidobacterium longum inhibits IgE production in vitro.
FEMS Immunology and Medical Microbiology,46(3):461-469 2006
Author:Takahashi N, Kitazawa H,Shimosato T, Iwabuchi N,Xiao JZ, IwatsukiK, KokuboS Saito T.

Toll-like receptor 2 and 9 are expressed and functional in gut-associated lymphoid tissues of presuckling newborn swine.
Veterinary Research,37(6):791-812 2006
Author:Tohno M,Shimosato T, Moue M, Aso H, Watanabe K, Kawai Y, Yamaguchi T, Saito T, Kitazawa H.

A swine Toll-like receptor 2-expressing transfectant as a potential primary screening system for immunobiotic microorganisms.
FEMS Immunology and Medical Microbiology,44(3):283-288 2005
Author:Tohno M, Kitazawa H,Shimosato T, Matsumoto M, Katoh S, Kawai Y,Saito T.

Strong immunostimulation inmurine immune cells by Lactobacillus rhamnosus GG DNA containing novel oligodeoxynucleotide pattern.
Cellular Microbiology,7(3):403-414 2005
Author:Iliev ID, Kitazawa H,Shimosato T, Katoh S, Saito T.

Toll-like receptor2 is expressed on the intestinal M cells in swine.
Biochemicaland BiophysicalResearch Communications,330(2):547-554 2005
Author:Tohno M*,Shimosato T*, Kitazawa H, Katoh S,Iliev ID, Watanabe K, Kawai Y,Aso H, Yamaguchi T, Saito T. *Tohno M. and Shimosato T. contributed equally to this work.

Augmentation of TH-1 type responseby immunoactive AT oligonucleotide from lactic acid bacteria via Toll-like receptor 9 signaling.
Biochemical and Biophysical Research Communications,326(4):782-787 2005
Author:Shimosato T, Kitazawa H, Tohno M, Katoh S, Iliev ID, Nagasawa C, Kawai Y, Saito T.

Toll-like receptor 9 is expressed on follicle-associated epithelia containing M cells in swine Peyer’s patches.
Immunology Letters,98(1):83-89 2005
Author:Shimosato T, Tohno M, KitazawaH, Katoh S, Watanabe K, KawaiY, Aso H, YamaguchiT, Saito T.

Dextran from Leuconostoc mesenteroides augments immunostimulatory effects by the introduction of phosphate groups.
Journal of Food Protection,67(8):1719-1724 2004
Author:Sato T, Nishimura-Uemura J,Shimosato T, Kawai Y, Kitazawa H, Saito T.

Cloning and Characterization of Swine Interleukin-17, Preferentially Expressed in the Intestines.
Journal of Interferon and Cytokine Research,24(9):553-559 2004
Author:Katoh S, Kitazawa H,Shimosato T, Tohno M, KawaiY, Saito T.

Development of immune assay system for both CpG and non-CpG DNA from lacticacid bacteria using a transfectant of swine Toll-like receptor 9
Animal Science Journal,75:377-382 2004
Author:Shimosato T, Kitazawa H, Tohno M, Katoh S, Kawai Y, Saito T.

Immunostimulatory oligonucleotide, CpG-like motif exists in Lactobacillus delbrueckii ssp. bulgaricus NIAI B6.
International Journal of Food Microbiology,85(1-2):11-21 2003
Author:Kitazawa H, WatanabeH,Shimosato T, Kawai Y, Itoh T, Saito T.

Swine Toll-like receptor 9 recognizes CpG motifs of human cell stimulant.
Biochemica et Biophysica Acta,1627(1):56-61 2003
Author:Shimosato T, Kitazawa H, Katoh S, Tomioka Y, Karima R, Ueha S, Kawai Y, Hishinuma T, Matsushima K, Saito T.

Presentations
The rpsL K56N mutation in Lacticaseibacillus rhamnosus GG enhances immune response via cell surface proteins
ISAPP 2023 annual meeting 2023(Jun. 27)
Presenter:Soyolmaa Jamiyanpurev, Fu Namai, Takashi Sato, Takeshi Shimosato

Effect of local intratracheal therapy using particleized nintedanib in a murine model of pulmonary fibrosis
American Thoracic Society 2023 International Conference 2023(May 24)
Presenter:Kaho Suzuki, Fu Namai, Natsumi Nomura, Yuichi Sato, Akihiro Kotsugai, Takeshi Shimosato, Takashi Sato

Intranasal administration of genetically modified Lactococcus lactis producing PD-L1scFv improves survival in lung cancer model mice (American Thoracic Society 2023・ATS Abstract Scholarship Award)
American Thoracic Society 2023 International Conference 2023(May 23)
Presenter:Natsumi Nomura, Fu Namai, Takashi Sato, Takeshi Shimosato

Bacterial changes associated with the rpsL gene mutation in Lacticaseibacillus rhamnosus GG
The 11th Asian Conference for Lactic Acid Bacteria 2021(Nov. 06)
Presenter:Masami Tsukagoshi, Fu Namai, Suguru Shigemori, Takeshi Shimosato

Lacticaseibacillus rhamnosus GGが高脂肪飼料断続給餌マウスに与える影響（若手優秀発表賞受賞）
酪農科学シンポジウム2021 2021(Sep. 24)
Presenter:鳥居創、重盛駿、下里剛士

Lactobacillus ingluviei C37 from broiler inhibits inflammation in LPS-stimulated mouse macrophages (English Presentation Award)
The 129th Annual Meeting of Japanese Society of Animal Science 2021(Sep. 15)
Presenter:Masami Tsukagoshi, Fu Namai, Suguru Shigemori, Ogita Tasuku, Takeshi Shimosato

Construction of genetically modified lactic acid bacteria producing anti-IL31Ra single-chain Fragment variable (English Presentation Award)
The 129th Annual Meeting of Japanese Society of Animal Science 2021(Sep. 15)
Presenter:Aito Murakami, Fu Namai, Suguru Shigemori, Ogita Tasuku, Takeshi Shimosato

「乳酸菌、腸内細菌およびミルクオリゴ糖の健康機能科学」-イムノバイオティクス由来核酸成分を用いた経口用微粒子の創製と機能性食品・飼料素材への展開-[招待講演]
日本食品科学工学会第66回大会 2019(Aug. 29)
Presenter:下里剛士

PD-1/PD-L1チェックポイントの阻害に働く乳酸菌組換え体の構築と肺ガンモデルマウスを用いた検証
2019年度酪農科学シンポジウム 2019(Aug. 23)
Presenter:上田麻未, 生井楓, 村上愛斗, 重盛駿, 荻田佑, 佐藤隆, 下里剛士

抗CTLA-4低分子抗体を産生するLactococcus lactis組換え体の構築（若手優秀ポスター賞受賞）
2019年度酪農科学シンポジウム 2019(Aug. 23)
Presenter:村上愛斗, 生井楓, 上田麻未, 重盛駿, 荻田佑, 佐藤隆, 下里剛士

Construction of a genetically modified Lactococcus lactis producing single chain Fv against vascular endothelial growth factor
13th International Scientific Conference on Probiotics, Prebiotics, Gut Mirobiota and Health 2019(Jun. 20)
Presenter:Masami Tsukagoshi, Fu Namai, Kohei Watanabe, Minako Iwai, Suguru Shigemori, Tasuku Ogita, Takashi Sato, Takeshi Shimosato

Ribosome engineering enhances production of p40, a Lactobacillus rhamnosus GG-derived soluble protein, in S12 mutant strains
13th International Scientific Conference on Probiotics, Prebiotics, Gut Mirobiota and Health 2019(Jun. 20)
Presenter:Shoko Kajikawa, Minori Ishida, Fu Namai, Suguru Shigemori, Tasuku Ogita, Takashi Sato, Takeshi Shimosato

Oral administration of a genetically modified osteocalcin-secreting Lactococcus lactis improves carbohydrate metabolism in high-fat diet-induced obese mice
13th International Scientific Conference on Probiotics, Prebiotics, Gut Mirobiota and Health 2019(Jun. 20)
Presenter:Fu Namai, Suguru Shigemori, Tasuku Ogita, Takashi Sato, Takeshi Shimosato

Oral delivery of CpG-oligodeoxynucleotide from lactic acid bacteria ameliorates high-fat-diet-induced obesity in mice
2018 Symposium of Korean Society for Lactic Acid Bacteria and Probiotics, Probiotics, Postbiotics, and Gut Health 2018(Nov. 30)
Presenter:Ryu Sugimura, Tasuku Ogita, Takeshi Shimosato

Flavonifractor plautii exerts Th1/Th2 immunomodulatory effects in mice
2018 Symposium of Korean Society for Lactic Acid Bacteria and Probiotics, Probiotics, Postbiotics, and Gut Health 2018(Nov. 30)
Presenter:Chika Fukasawa, Tasuku Ogita, Takeshi Shimosato

Flavonifractor plautii inhibits inflammatory responses in lipopolysaccharide-stimulated RAW 264.7 cells and alleviates acute-colitis in mice
2018 Symposium of Korean Society for Lactic Acid Bacteria and Probiotics, Probiotics, Postbiotics, and Gut Health 2018(Nov. 30)
Presenter:Ayane Mikami, Tasuku Ogita, Takeshi Shimosato

「スマートバイオデザイン：ナノからマクロスケールまでの様々な階層レベルにおけるバイオ関連機能と構造の合理的創出を目指して」-オリゴDNAの腸管送達系の構築と経口用素材への展開-[招待講演]
第70回日本生物工学会大会 2018(Aug. 31)
Presenter:下里剛士

Construction of Oligodeoxynucleotide Particles using Glycosylated Carbonate Apatite and Targeted Delivery to Macrophages
18th AAAP Congress 2018(Aug. 01)
Presenter:Shuichiro Yamashina, Mitsuaki Goto, Takeshi Shimosato

Recombinant mouse calcitonin gene-related peptidesecreted by Lactococcus lactis inhibits lipopolysaccharide-induced inflammatory response in macrophages
18th AAAP Congress 2018(Aug. 01)
Presenter:Fu Namai, Tasuku Ogita, Takeshi Shimosato

Advanced Application of Ribosome Engineering in Lactobacillus rhamnosus GG
18th AAAP Congress 2018(Aug. 01)
Presenter:Minori Ishida, Fu Namai, Tasuku Ogita, Takeshi Shimosato

Immunoregulatory function of Flavonifractor plautii
18th AAAP Congress 2018(Aug. 01)
Presenter:Tasuku Ogita, Fu Namai, Ayane Mikami, Takeshi Shimosato

Class-B Oligodeoxynucleotide Derived from a Lactic Acid Bacterium Induces Apoptosis in Spleen Cells
18th AAAP Congress 2018 2018(Aug. 01)
Presenter:Nobuhiro Ambe, Yoshinari Yamamoto, Tasuku Ogita, Takeshi Shimosato

Construction of genetically modified Lactococcus lactissecreting bioactive osteocalcin
International Dairy Federation (IDF) World Dairy Summit 2017 2017(Nov. 01)
Presenter:Fu Namai, Suguru Shigemori, Tasuku Ogita, Takeshi Shimosato

Free-feeding of DNA nanocapsules containing CpG oligodeoxynucleotide from Streptococcus thermophilus
International Dairy Federation (IDF) World Dairy Summit 2017 2017(Nov. 01)
Presenter:Takuma Okajima, Yoshinari Yamamoto, Tasuku Ogita, Takeshi Shimosato

Effect of Fishery Related Activities on the Food and Nutrition Situation of Indigenous Community in Bangladesh: A Study of Adolescent girl
Proceedings of the 17th AAAP Congress 2016(Aug. 25)
Presenter:Shireen Nigar, Takeshi Shimosato, Abu Torab Md. Abdur Rahim

Immunostimulatory oligodeoxynucleotide from lactic acid bacteria promotes the anaphylaxis to ovalbumin in mice
Proceedings of the 17th AAAP Congress 2016(Aug. 25)
Presenter:Yoshinari Yamamoto, Takuma Okajima, Tasuku Ogita, Takeshi Shimosato

Dose-comparison study of Lactococcus lactis producing heme oxygenase-1 for treatment of dextran sulfate sodium-induced acute colitis in mice
Proceedings of the 17th AAAP Congress 2016(Aug. 25)
Presenter:Suguru Shigemori, Tasuku Ogita, Takeshi Shimosato

CpG oligodeoxynucleotide from Streptococcus thermophilus induces type 2 innate lymphoid cells（Young Scientists Award/JSAS Excellent Presentation Award受賞）
Proceedings of the 17th AAAP Congress 2016(Aug. 23)
Presenter:Takuma Okajima, Yoshinari Yamamoto, Tasuku Ogita, Takeshi Shimosato

乳酸菌由来オリゴ核酸のアナフィラキシーショック亢進メカニズム（若手優秀ポスター賞受賞）
平成27年度酪農科学シンポジウム 2015(Sep. 25)
Presenter:山本祥也, 岡島拓真, Nigar Shireen, 重盛駿, 下里剛士

ヘムオキシゲナーゼ-1を分泌する乳酸菌組換え体はマウスにおける急性大腸炎を軽減する（日本畜産学会第120回大会優秀発表賞受賞）
日本畜産学会第120回大会 2015(Sep. 11)
Presenter:重盛駿, 山本祥也, 下里剛士

Construction of genetically modified Lactococcus lactis expressing buckwheat protein Fagag1 with strong allergenicity
2015 ADSA-ASAS Joint Annual Meeting (JAM) 2015(Jul. 14)
Presenter:Suguru Shigemori, Yoshinari Yamamoto, Kazushi Oshiro, Pengfei Wang, Yeqin Wang, Takashi Sato,Takeshi Shimosato

Production of recombinant β-lactoglobulin in Lactococcus lactis and generation of a bioactive peptide with incretin-inactivation activity
2015 ADSA-ASAS JointAnnual Meeting (JAM) 2015(Jul. 14)
Presenter:Kazushi Oshiro, Suguru Shigemori, Yoshinari Yamamoto, Pengfei Wang, Yeqin Wang, Takashi Sato,Takeshi Shimosato

Development of an anaphylactic model of buckwheat using B-type CpG oligodeoxynucleotides from lactic acid bacteria
2015 ADSA-ASAS Joint Annual Meeting (JAM) 2015(Jul. 14)
Presenter:Yoshinari Yamamoto, Suguru Shigemori, Kazushi Oshiro, Pengfei Wang, Yeqin Wang, Takashi Sato,Takeshi Shimosato

Intracellular expression of cow’s milk allergens in genetically modified Lactococcus lactis
Proceedings of the 16th AAAP Congress 2014(Nov. 12)
Presenter:Suguru Shigemori, Yoshinari Yamamoto, Pengfei Wang, Yeqin Wang,Takeshi Shimosato

Strong immunostimulatory activity of oligodeoxynucleotide motifs from lactic acid bacteria
Proceedings of the 16th AAAP Congress 2014(Nov. 12)
Presenter:Yoshinari Yamamoto, Suguru Shigemori, Pengfei Wang, Yeqin Wang,Takeshi Shimosato

インターロイキン6特異的抗体を分泌する乳酸菌組換え体の構築（若手優秀ポスター賞受賞）
平成26年度日本酪農科学シンポジウム 2014(Sep. 12)
Presenter:重盛駿, 大城和士, Wang Pengfei, 山本祥也, Wang Yeqin, 下里剛士

Expression of immunoreactive αS1-casein in Lactococcus lactis as a treatment strategy for milk allergy
International Dairy Federation, World Dairy Summit 2013 2013(Oct. 28)
Presenter:Suguru Shigemori, Hajime Otani,Takeshi Shimosato

Immunostimulatory oligodeoxynucleotide from yogurt starter bacteria Streptococcus thermophilus, strongly induces interleukin 33
International Dairy Federation, World Dairy Summit 2013 2013(Oct. 28)
Presenter:Yusuke Ito, Suguru Shigemori, Hajime Otani, Haruki Kitazawa,Takeshi Shimosato

CpG oligodeoxynucleotides promote wound healing in airway epithelial cells
American Thoracic Society Annual Meeting 2011 2011
Presenter:Sato T, Miyazawa N, KlinmanDM,Shimosato T, Takahashi R, Tsukahara T, Hayashi M, Yamamoto M, Tomaru K, Kaneko T, Ishigatsubo Y.

Toll-like receptor 4recognizes extracellular polysaccharide from Lactococcus lactis subsp. cremoris
4th congress of european microbiologists FEMS 2011
Presenter:Tohno M,Shimosato T, Aso H, Kitazawa H.

Suppressive Oligodeoxynucleotide Synergistically Enhances The Antiproliferative Effect Of Anti-cancer Drug In Human Lung Cancer Cells
American Thoracic Society Annual Meeting 2011 2011
Presenter:Takahashi R, Sato T, Miyazawa N, Klinman DM,Shimosato T, Hayashi M, Yamamoto M, Tomaru K, Tsukahara T, Kaneko T, Ishigatsubo Y.

Evaluation of Anti-Inflammatory Immunobiotics in Porcine Intesinal Epithelial Cells
International ScientificConference on Probiotics andPrebiotics - IPC2010 2010
Presenter:Kitazawa H, Shimazu T, Tohno M, Villena J, Hosoya S, Fujie H, Suda Y,Shimosato T, Aso H, Makino S, Ikegami S, Kawai Y, Saito T.

Effect of immunobiotics on the immune performance and productivity of pigs
International Scientific Conference on Probiotics and Prebiotics - IPC2010 2010
Presenter:SudaY, TakahashiY, Tohno M, Villena Julio, Hosoya S, Fujie H,Shimosato T, Kobashi J, Ishida M, Aso H, Kawai Y, Saito T, Makino S, Ikegami S, Kitazawa H.

Accelerated wound healing in mice by local administration of sustained-release CpG oligodeoxynucleotide.
97th AAI Annual Meeting 2010
Presenter:Sato T,Shimosato T, Klinman DM.

The novel immunostimulatory activities of CpG oligodeoxynucleotides from Streptococcus thermophilus
ADSA-PSA-AMPA-CSAS-ASAS Joint Annual Meeting (JAM) 2010
Presenter:Shimosato T, Fujimoto M, Tohno M, Sato T, Otani H, Kitazawa H.

Immunoregulation of immunobiotic lactic acid bacterial DNA and their advanced application to Food Science
Shinshu University International Symposium 2010 in Ina, Sustainable Agriculture and Environment: Asian Network II, proceedings 2010
Presenter:Takeshi Shimosato

CpG oligodeoxynucleotide from Streptococcus thermophilus regulates anti-inflammatory responses
ADSA-CSAS-ASAS 2009 Joint Annual Meeting 2009
Presenter:Shimosato T, Tohno M, Sato T, Kitazawa H

REGULATION OF INFLAMMATORY RESPONSE BY IMMUNOBIOTICS IN SWINE INTESTINAL EPITHELIAL CELLS VIA MKP-1
The 9th World Congress on Inflammation 2009
Presenter:ShimazuT, Tohno M, Hosoya S, Fujie H,Shimosato T, Aso H, Suda Y, KawaiY, Saito T, Kitazawa H.

CpG oligodeoxynucleotide from Streptococcus thermophilus lacZ strongly induces the expression of interleukin-33 in murine immune cells
The 9th World Congress on Inflammation 2009
Presenter:Shimosato T, Tohno M, Sato T, Tateo M, Otani H, Kitazawa H

CpG oligodeoxynucleotide incorporated basement membrane extract facilitate wound repair in mice
96th AAI Annual Meeting 2009
Presenter:Sato T,Shimosato T, Klinman DM

「イムノバイオティクス由来の新規免疫刺激性DNAモチーフの発見とその将来性」[招待講演]
平成20年度酪農科学シンポジウム 2008(Aug. 29)
Presenter:下里剛士

Suppressive oligodeoxynucleotides improve outcome in murine silicosis
American Thoracic Society Annual Meeting 2008 2008
Presenter:SatoT,Shimosato T, Klinman DM

Immuno-stimulatory AT oligodeoxynucleotide from Lactobacillus gasseri requires a specific self-stabilized structure
ADSA-ASAS 2008 Joint Annual Meeting 2008
Presenter:Shimosato T, Tohno M, Sato T, Kawai Y, Saito T, Kitazawa H

Immune responses of Immunobiotics and Immunogenics via Toll-like receptors and their advancedapplication to Food immunology
2nd International Bio-microcosmos Workshop 2006
Presenter:Kitazawa H,Shimosato T, Tohno M, Saito T

Development of a novel immunoassay system for immunobiotics that modulate intestinal immunity through Toll-likereceptor 2
ADSA-ASAS 2006 Joint Annual Meeting 2006
Presenter:Tohno M,Shimosato T, Kawai, Y, Saito T. Kitazawa H,

Immunobiotic lactic acid bacteria induce immune responses in immature gut-associatedlymphoid tissues via Toll-likereceptors 2 and 9
ADSA-ASAS 2006 Joint Annual Meeting 2006
Presenter:Kitazawa H, Tohno M,Shimosato T, Aso H, Kawai, Y, Saito T.

Swine intestinal immunity via Toll-like receptors and its advanced application to Food immunology
International Symposium on Recent Advances in Animal Science 2005
Presenter:Kitazawa H,Shimosato T, Tohno M, Saito T

AT oligonucleotide from"Immunobiotic"Lactobacillus gasseri augments immune responses via Toll-like receptor 9 signaling
ADSA-ASAS 2004 Joint Annual Meeting 2004
Presenter:Shimosato T, Kitazawa H, Tohno M, Katoh S, Kawai, Y, Saito T.

Immunostimulatory activities of a novel AT oligonucleotide from "Immunobiotic" Lactobacillus gasseri on swine Peyer's patch cells
Journal of Dairy Science 87 417 2004
Presenter:Kitazawa H,Shimosato T, Katoh S, Tohno M, Kawai, Y, Saito T.

MISC
機能強化乳酸菌の創製研究
日本乳酸菌学会誌,33(1):5-11 2022(Mar.)
Author:生井楓，下里剛士

乳酸菌オリゴDNAを腸まで届ける経口用ナノカプセルの開発
JATAFFジャーナル,6(3):27-33 2018(Mar. 01)
Author:下里剛士

ビール酵母とその牛乳抗体のマウスにおけるアレルギー軽減作用と急性毒性に関する検討
北信越畜産学会報,106:35-47 2013
Author:森崎健太郎，松田孝裕，須賀正喜，荻田佑，平松浩二，下里剛士，大谷元

免疫刺激性オリゴヌクレオチドの2次構造特性
Journal of the Faculty of Agriculture SHINSHU UNIVERSITY,46(1-2):1-5 2010
Author:下里剛士

イムノジェニクスとしての免疫刺激性DNA研究の最前線
北信越畜産学会報,(100):1-9 2010
Author:下里剛士，北澤春樹.

Preparation of goat milk anti-Saccharomyces cerevisiae immunoglobulin G (IgG)-rich fraction and immunological functions of mice orally administered a mixture of the antigen and its specific IgG-rich fraction
Milk Science,58(3):119-128 2009
Author:Sekimura Y, Onodera N, Banno M, Hata I, HamanoK,Shimosato T, Hajime O.

イムノバイオティクス由来の新規免疫刺激性DNAモチーフの発見とその将来性
Milk Science,57(3):103-107 2009
Author:下里剛士，北澤春樹.

豚腸管におけるToll様受容体の機能発現と食品免疫学への応用.
獣医畜産新報,59(7):559-561 2006
Author:北澤春樹，遠野雅徳，下里剛士，齋藤忠夫.

Swine intestinal immunity via Toll-like Receptors and its advanced application to food immunology.
Journal of Integrated Field Science,3:9-14 2006
Author:Kitazawa H,Shimosato T, Tohno M, Saito T.

Immunostimulatory Activities of Lactic Acid Bacteria via Toll-like Receptors.
Japanese Journal of Lactic Acid Bacteria,16(1):11-20 2005
Author:Kitazawa H,Shimosato T, TohnoM, Saito T.

Toll様受容体9を介するイムノバイオティック乳酸菌DNAの免疫活性とその将来性．
Milk Science,54(1):9-15 2005
Author:下里剛士，北澤春樹，齋藤忠夫．

Patents: Patents
US8163506: USE OF TOLL-LIKE RECEPTOR-EXPRESSING CELLS
4562123: Toll様レセプター強制発現細胞の利用
5403457: ATオリゴヌクレオチドを有効成分とする免疫応答増強性薬剤及び食品組成物

Research Grants: Grants‐in‐aid for Scientific Research(Research Representative)
2020 - 2023 , 経口用乳酸菌オリゴDNA微粒子の最適化と腸管上皮を起点とする免疫制御機構の解明 , 基盤研究B
2020 - 2021 , スマート乳酸菌の創製研究 , 挑戦的研究（萌芽）
2017 - 2020 , 乳酸菌オリゴDNAを有効成分とする経口用ナノカプセルを用いた免疫調節機構の解明 , 基盤研究B
2012 - 2015 , 乳酸菌DNAのナノカプセル体を用いた新規食品および飼料素材開発のための基盤構築 , 基盤研究C
2010 - 2012 , プロバイオティック乳酸菌DNAの機能性食品および飼料素材としての利用法の開発 , 若手研究B
2008 - 2010 , ナノ粒子を用いた抗アレルギーDNAワクチンの腸管粘膜系における免疫応答機構の解明 , 若手研究B

Grants‐in‐aid for Scientific Research(Researcher)
2019 - 2022 , 免疫チェックポイント阻害乳酸菌による肺癌発癌予防・進展予防効果の検証 , 国際共同研究加速基金国際共同研究強化B
2018 - 2019 , 吸入療法イノベーションの実現：高分子・抗体医薬の経気道投与による肺癌治療戦略 , 挑戦的研究（萌芽）
2016 - 2018 , ナノ粒子化免疫調節剤の呼吸器疾患への治療応用の研究 , 基盤研究C

Other Research Grants
2020 - 2022 , 国立研究開発法人新エネルギー・産業技術総合開発機構（NEDO）官民による若手研究者発掘支援事業・マッチングサポートフェーズ（代表）
2017 - 2019 , 国立研究開発法人日本医療研究開発機構（AMED）創薬基盤推進研究事業（分担）
2014 - 2015 , 研究成果最適展開支援プログラム A-STEP「フィージビリティスタディ（ＦＳ）・ステージ」探索タイプ（代表）
2011 - 2012 , 研究成果最適展開支援プログラム A-STEP「フィージビリティスタディ（ＦＳ）・ステージ」探索タイプ（代表）

Education

Lectures: 動物資源化学実験
細胞システム科学特論
先端生命科学特論／生命産業科学特論
科学英語I
食と微生物
Animal Science
畜産物利用学
動物生命科学
動物資源生命科学概論
分子生命工学特論
Advanced Study for Life Science
先鋭領域融合研究群最先端研究特講

International Student Receipt: 2020 , First Term:1 , Second Term:2 , モンゴル（2）
2019 , First Term:2 , Second Term:2 , ベルギー（1），モンゴル（1）

Social Activities

Social Activitie: Presentations and Special Lectures
20210303 - , 「食」と「健康」ラボ研究会第6回シンポジウム , 講師 , 甘酒およびその成分による整腸作用（プレバイオティクス効果）
20190821 - , 令和元年度第三回信州機能性食品開発研究会 , 甘酒投与に伴うマウス腸内細菌叢の変動と整腸作用の検証
20181218 - , 平成30年度第三回信州機能性食品開発研究会 , 招待講演 , 長寿地域“信州”から発信する乳酸菌科学
20180823 - , 安曇野市市民大学講座 , ヨーグルトの健康機能〜乳酸菌科学の最前線〜
20180126 - , 第8回化粧品開発展 -COSME Tech 2018- , オリゴDNAの腸管送達系の開発と経皮素材への展開
20171027 - , 信州コロイド＆界面科学研究会 , 招待講演 , オリゴDNAの腸管送達系の構築と全身免疫系の制御
20171004 - , アグリビジネス創出フェア2017 , 農林水産省・若手農林水産研究者表彰・農林水産技術会議会長賞受賞講演 , 乳酸菌オリゴDNAを腸まで届ける経口用ナノカプセルの開発
20151127 - , 第14回日本農学進歩賞受賞講演会 , 受賞講演会 , 乳酸菌オリゴDNAの腸管送達系の構築と免疫制御に関する研究
20150304 - , 第二回信大見本市ミニプレゼンテーション「“食べる”機能性DNAの開発」
20110904 - , 健康食品管理士会長野県分科会講演会 , 招待講演 , 演題「ヨーグルトの保健機能〜プロバイオティクスの魅力とその研究最前線〜」
20110120 - , 平成２２年度「信州大学医農連携交流会」 , 招待講演 , 乳酸菌オリゴヌクレオチドの免疫調節作用

Shinshu University Researcher Directory

Shimosato Takeshi

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Education

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Shimosato　Takeshi