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YOSHIZAWA Takahiro

Academic OrganizationAcademic Assembly School of Medicine and Health Sciences Institute of MedicineTEL
Education and Research OrganizationResearch Center for Supports to Advanced Science (RCSAS)FAX
PositionAssistant ProfessorMail Addresstyoshizawa(at)shinshu-u.ac.jp
Address3-1-1, Asahi, Matsumoto City 390-8621Web sitehttp://www.shinshu-u.ac.jp/institution/hito/i-animal/

Modified:07/08/2019

Profile

Research Field
laboratory animal science
Basic Medical Science
Current Subject
Development of human disease model animals for rare diseases
Keywords:mcEDS, FSHD
translational research
Keywords:pathogenesis
Academic Background
Graduate School
2013

College
2007

Degree
Ph.D. , Shinshu University (Japan)
Awards
2012
2011
2011
2011
2010
Research Career
Research Career
2016-
2013-
2011-

Research

Books, Articles, etc.
Articles
Cutting Edge: TAK1 Safeguards Macrophages against Proinflammatory Cell Death.
The Journal of Immunology 2019(Jun. 26)
Author:Hideki Sanjo, Jun Nakayama, Takahiro Yoshizawa, Hans Joerg Fehling, Shizuo Akira and Shinsuke Taki


Continuous Measurement of Locomotor Activity During Convalescence and Acclimation in Group-Housed Rats
Experimental Animals,Advance Publication 2019(Feb. 13)
Author:Takahiro Yoshizawa, Shin Shimada, Yoshito Takizawa, Tsuyoshi Makino, Yasuhide Kanada, Yoshiharu Ito, Toshiaki Ochiai, and Kiyoshi Matsumoto


Evaluation of Necessity of 1-year Toxicity Study in Dogs - development of the New Tiered Approach for Toxicity Studies of Pesticide Considering Species Difference in “toxicity profile” and “toxicity dose-response”
Food Safety 2018(May 31)
Author:Atsushi Ono, Takahiro Yoshizawa, Kiyoshi Matsumoto


Vascular abnormalities in the placenta of Chst14-/- fetuses: implications in the pathophysiology of perinatal lethality of the murine model and vascular lesions in human CHST14/D4ST1 deficiency
Glycobiology,28(2):80-89 2018(Jan. 05)
Author:Takahiro Yoshizawa, Shuji Mizumoto, Yuki Takahashi, Shin Shimada, Kazuyuki Sugahara, Jun Nakayama, Shin’ichi Takeda, Yoshihiro Nomura, Yuko Nitahara-Kasahara, Takashi Okada, Kiyoshi Matsumoto, Shuhei Yamada, and Tomoki Kosho


Effects of Adrenomedullin on Doxorubicin-induced Cardiac Damage in Mice
Biological and Pharmaceutical Bulletin,39(5) 2016(Feb. 22)
Author:Takahiro Yoshizawa, Sho Takizawa, Shin Shimada, Takeshi Tokudome, Takayuki Shindo, and Kiyoshi Matsumoto


Differential roles of MMP-9 in early and late stages of dystrophic muscles in a mouse model of Duchenne muscular dystrophy
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,1852(10):2170-2182 2015(Oct.)
Author:Shiba, Naoko; Miyazaki, Daigo; Yoshizawa, Takahiro; Fukushima, Kazuhiro; Shiba, Yuji; Inaba, Yuji; Imamura, Michihiro; Takeda, Shin'ichi; Koike, Kenichi; Nakamura, Akinori;


アドレノメデュリン-RAMP2系の病態生理学的意義
お茶の水医学雑誌,63(2):331-338 2015(Jul.)
Author:新藤優佳, 桜井敬之, 神吉昭子, 河手久香, 小山晃英, 吉沢隆浩, 新藤隆行


Adrenomedullin-RAMP2 System Suppresses ER Stress-Induced Tubule Cell Death and Is Involved in Kidney Protection
PLOS ONE,9(2):- 2014(Feb. 05)
Author:Uetake, Ryuichi; Sakurai, Takayuki; Kamiyoshi, Akiko; Ichikawa-Shindo, Yuka; Kawate, Hisaka; Iesato, Yasuhiro; Yoshizawa, Takahiro; Koyama, Teruhide; Yang, Lei; Toriyama, Yuichi; Yamauchi, Akihiro; Igarashi, Kyoko; Tanaka, Megumu; Kuwabara, Takashige; Mori, Kiyoshi; Yanagita, Motoko; Mukoyama, Masashi; Shindo, Takayuki;


Endogenous CGRP protects against neointimal hyperplasia following wire-induced vascular injury
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY,59:55-66 2013(Jun.)
Author:Yang, Lei; Sakurai, Takayuki; Kamiyoshi, Akiko; Ichikawa-Shindo, Yuka; Kawate, Hisaka; Yoshizawa, Takahiro; Koyama, Teruhide; Iesato, Yasuhiro; Uetake, Ryuichi; Yamauchi, Akihiro; Tanaka, Megumu; Toriyama, Yuichi; Igarashi, Kyoko; Shindo, Takayuki;


Adrenomedullin-RAMP2 System Is Crucially Involved in Retinal Angiogenesis
AMERICAN JOURNAL OF PATHOLOGY,182(6):2380-2390 2013(Jun.)
Author:Iesato, Yasuhiro; Toriyama, Yuichi; Sakurai, Takayuki; Kamiyoshi, Akiko; Ichikawa-Shindo, Yuka; Kawate, Hisaka; Yoshizawa, Takahiro; Koyama, Teruhide; Uetake, Ryuichi; Yang, Lei; Yamauchi, Akihiro; Tanaka, Megumu; Igarashi, Kyoko; Murata, Toshinori; Shindo, Takayuki;


Novel Regulation of Cardiac Metabolism and Homeostasis by the Adrenomedullin-Receptor Activity-Modifying Protein 2 System
HYPERTENSION,61(2):341-+ 2013(Feb.)
Author:Takahiro Yoshizawa, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Yasuhiro Iesato, Teruhide Koyama, Ryuichi Uetake, Lei Yang, Akihiro Yamauchi, Megumu Tanaka, Yuichi Toriyama, Kyoko Igarashi, Tsutomu Nakada, Toshihide Kashihara, Mitsuhiko Yamada, Hayato Kawakami, Hiroki Nakanishi, Ryo Taguchi, Tsuyoshi Nakanishi, Hiroshi Akazawa, Takayuki Shindo.


アドレノメデュリン-RAMP2システムは,小胞体ストレス誘導性細胞死を抑制し,腎保護的に働く (Adrenomedullin-RAMP2 system suppresses ER stress-induced cell death  and works for kidney protection.)
血管,36(3):89-94 2013
Author:植竹 龍一,桜井 敬之,神吉 昭子,新藤 優佳,河手 久香,吉沢 隆浩,小山 晃英, 家里 康弘,楊 磊,鳥山 佑一,山内 啓弘,五十嵐 恭子,田中 愛,新藤 隆行


Vascular Endothelial Adrenomedullin-RAMP2 System Is Essential for Vascular Integrity and Organ Homeostasis
CIRCULATION,127(7):842-853 2013
Author:Koyama, Teruhide; Ochoa-Callejero, Laura; Sakurai, Takayuki; Kamiyoshi, Akiko; Ichikawa-Shindo, Yuka; Iinuma, Nobuyoshi; Arai, Takuma; Yoshizawa, Takahiro; Iesato, Yasuhiro; Lei, Yang; Uetake, Ryuichi; Okimura, Ayano; Yamauchi, Akihiro; Tanaka, Megumu; Igarashi, Kyoko; Toriyama, Yuichi; Kawate, Hisaka; Adams, Ralf H.; Kawakami, Hayato; Mochizuki, Naoki; Martinez, Alfredo; Shindo, Takayuki;


アドレノメデュリンーRAMP 2系による心臓エネルギー代謝制御と恒常性維持 (Adrenomedullin-RAMP2 system regulates cardiac metabolism and homeostasis.)
血管,35(2):63-67 2012(Jul. 02)
Author:吉沢 隆浩; 桜井 敬之; 神吉 昭子; 河手 久香; 新藤 優佳; 荒居 琢磨; 小山 晃英; 家里 康弘; 楊 磊; 植竹 龍一; 山内 啓弘; 田中 愛; 川上 速人; 中西 広樹; 田口 良; 新藤 隆行;


血管内皮細胞のアドレノメデュリン-RAMP 2システムによる血管恒常性維持機構 (Vascular endothelial Adrenomedullin-RAMP2 system is essential for maintenance of vascular homeostasis.)
血管,34(4):153-157 2011(Dec. 31)
Author:小山 晃英; 桜井 敬之; 神吉 昭子; 新藤 優佳; 河手 久香; 荒居 琢磨; 家里 康弘; 吉沢 隆浩; 楊 磊; 植竹 龍一; 五十嵐 恭子; 鳥山 佑一; 沖村 綾乃; 山内 啓弘; 田中 愛; 新藤 隆行;


Induction of LYVE-1/stabilin-2-posotive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling.
Peptides,32(9):1855-1865 2011
Author:Arai T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Iinuma N, Iesato Y, Koyama T, Yoshizawa T, Uetake R, Yamauchi A, Yang L, Kawate H, Ogawa S, Kobayashi A, Miyagawa S, Shindo T.


Adrenomedullin in sinusoidal endothelial cells play protective roles against cold injury of liver.
Peptides,31(5):865-871 2010
Author:Iinuma N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Arai T, Yoshizawa T, Koyama T, Uetake R, Kawate H, Muto S, Tagawa Y, Miyagawa S, Shindo T.


アドレノメデュリン-RAMP 2システムによる血管新生および血管構造維持機構 (Regulation of angiogenesis and vascular integrity by adrenomedullin-RAMP2 system.)
血管,32(2):33-35 2009(Jun. 23)
Author:新藤 優佳; 桜井 敬之; 神吉 昭子; 小山 晃英; 吉沢 隆浩; 新藤 隆行;


Endogenous a-calcitonin gene-related peptide mitigates liver fibrosis in chronic hepatitis induced by repeatedadministration of concanavalin A.
Liver International,29(5):642-649 2009
Author:Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Iinuma N, Kawate H, Yoshizawa T, Koyama T, Muto S, Shindo T.


GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity.
Journal of Clinical Investigation,118(1):29-39 2008
Author:Ichikawa-Shindo Y, Sakurai T, Kamiyoshi A, Kawate H, Iinuma N, Yoshizawa T, Koyama T, Fukuchi J, Iimuro S, Moriyama N, Kawakami H, Murata T, Kangawa K, Nagai R, Shindo T.


Presentations
食品機能や安全性の評価を行なう際の実験動物の適正な飼育環境の重要性
日本食品化学学会第25回総会・学術大会 2019(Jun. 07)
Author:吉沢隆浩 、嶋田新、滝沢義人、金田康秀 、牧野剛士、金子稔 、伊藤嘉春、落合敏秋、山中仁木、松本清司


信州大学における学内研究者向けのCRISPR/Cas9によるゲノム編集動物作出支援業務の立ち上げ(Setup of Support Service to Generate Genome-Edited Mouse with CRISPR/Cas9 in Shinshu University)
第66回 日本実験動物学会総会 2019(May 16)
Author:吉沢隆浩、嶋田新、山中仁木、松本清司


ゲノム編集動物作出支援業務立ち上げの本学動物実験支援部門での一例
信州実験動物研究会 2019(Mar. 01)
Author:吉沢隆浩、嶋田新、山中仁木、松本清司


Pathophysiological investigation of Musculocontractural Ehlers–Danlos Syndrome caused by mutations in CHST14 (mcEDS-CHST14) using knockout mice
International Symposium on the Ehlers-Danlos Syndromes 2018(Sep. 28)
Author:Takahiro Yoshizawa, Shuji Mizumoto, Yuki Takahashi, Shin Shimada, Kazuyuki Sugahara, Jun Nakayama, Shin’ichi Takeda, Yoshihiro Nomura, Yuko Nitahara-Kasahara, Takashi Okada, Kiyoshi Matsumoto, Shuhei Yamada, Tomoki Kosho


新型エーラスダンロス症候群のモデル動物としてのChst14遺伝子欠損マウス胎盤の解析(Analysis of Placenta of Chst14 Gene-deleted Mice as the Model of DDEDS, a New Type of Ehlers-Danlos Syndrome)
日本実験動物学会 2017(May 26)
Author:Takahiro Yoshizawa, Yuki Takahashi, Shin Shimada, Shuji Mizumoto, Kiyoshi Matsumoto, Tomoki Kosho


体内埋め込み型活動量計nano tag を用いた順化検討実験(Analysis of Locomotor Activity in the Period for Convalescence and Acclimation Using “nano tag”, a New-type Device)
日本実験動物学会 2017(May 25)
Author:Kiyoshi Matsumoto, Takahiro Yoshizawa et al.


Placental phenotypes of Chst14 -/- fetal mice: a model for vascular manifestations in Ehlers-Danlos syndrome caused by CHST14/D4ST1 deficiency
International Congress of Human Genetics , The 13th International Congress of Human Genetics (ICHG2016) 2016(Apr. 04)
Author:Takahiro Yoshizawa, Shuji Mizumoto, Jun Nakayama, Takuya Hirose, Kazushige Takehana, Fengming Yue, Nana Tsumita, Chiaki Masuda, Yuko Kasahara, Yuki Takahashi, Shin-ichi Takeda, Takashi Okada, Kiyoshi Matsumoto, Tomoki Kosho


The influence of the material of rearing cage, paper chip, metal mesh or resinous board in rat
日本実験動物学会 2015(May 28)
Author:Takahiro Yoshizawa, Sho Takizawa, Shin Shimada, Norihisa Shiohara, Keisuke Kozima, Minoru Kaneko, Kiyoshi Matsumoto

Research Grants
Grants‐in‐aid for Scientific Research(Research Representative)
2019 - 2021 , 新型エーラスダンロス症候群の皮膚症状の疾患モデル動物確立と病態メカニズム解明 , 科学研究費助成事業 基盤研究(C)
2016 - 2018 , 新型エーラスダンロス症候群の疾患モデル動物の確立と病態メカニズム解明 , 科学研究費助成事業 若手研究(B)
2014 - 2015 , 心不全におけるミトコンドリア制御・保護因子の探索と病態生理学的意義の解明 , 科学研究費助成事業 若手研究(B)

Grants‐in‐aid for Scientific Research(Researcher)
2014 - 2015 , 筋ジストロフィーに対するMMP-9を標的とした新規治療法の開発 , 科学研究費助成事業 若手研究(B)
Research Activities
Journal Reviewer
Experimental Animals