UEMURA Takeshi
Academic Assembly School of Humanities and Social Sciences Institute of Humanities
Research Center for Advanced Science and Technology
Professor
Researcher Information
Research Keyword
- CNS, neural circuit formation, neurodevelopmental disorders, synapse
TEL
- +81-263-37-3108
Research activity information
Paper
- Development of phosphate-treated PEEK implants with high osseointegration
Yu Usuda, Takumi Okihara, Shigeaki Moriyama, Takeshi Uemura, Takayuki Kamanaka, Aoi William Omi, Naoto Saito, Jun Takahashi, Kaoru Aoki, Naoyuki Nishimura
Materials Today Communications, 38, 107717, Mar. 2024
- Biocompatibility Evaluation of Carbon Nanohorns in Bone Tissues
Ueda, K; Ma, C; Izumiya, M; Kuroda, C; Ishida, H; Uemura, T; Saito, N; Aoki, K; Haniu, H
Nanomaterials, Jan. 2023
- Neurexins in serotonergic neurons regulate neuronal survival, serotonin transmission, and complex mouse behaviors
Cheung, A; Konno, K; Imamura, Y; Matsui, A; Abe, M; Sakimura, K; Sasaoka, T; Uemura, T; Watanabe, M; Futai, K; Brose, N
Elife, Jan. 2023
Lead, Corresponding - Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins
Uemura, Takeshi; Suzuki-Kouyama, Emi; Kawase, Shiori; Kurihara, Taiga; Yasumura, Misato; Yoshida, Tomoyuki; Fukai, Shuya; Yamazaki, Maya; Fei, Peng; Abe, Manabu; Watanabe, Masahiko; Sakimura, Kenji; Mishina, Masayoshi; Tabuchi, Katsuhiko;
CELL REPORTS, 39(1), 110624, 2022 - IQSEC3 Deletion Impairs Fear Memory Through Upregulation of Ribosomal S6K1 Signaling in the Hippocampus
Kim, Dongwook; Jung, Hyeji; Shirai, Yoshinori; Kim, Hyeonho; Kim, Jinhu; Lim, Dongseok; Mori, Takuma; Lee, Hyojeong; Park, Dongseok; Kim, Hee Young; Guo, Qi; Pang, Bo; Qiu, Wen; Cao, Xueshan; Kouyama-Suzuki, Emi; Uemura, Takeshi; Kasem, Enas; Fu, Yu; Kim, Seungjoon; Tokunaga, Akinori; Yoshizawa, Takahiro; Suzuki, Tatsuo; Sakagami, Hiroyuki; Lee, Kea Joo; Ko, Jaewon; Tabuchi, Katsuhiko; Um, Ji Won;
Biological Psychiatry, 91(9), 821-831, 2022 - Future Prospects for Clinical Applications of Nanocarbons Focusing on Carbon Nanotubes
Saito, Naoto; Haniu, Hisao; Aoki, Kaoru; Nishimura, Naoyuki; Uemura, Takeshi;
ADVANCED SCIENCE, 2201214, 2022
Last - Evaluation of MC3T3-E1 Cell Osteogenesis in Different Cell Culture Media
Izumiya, Makoto; Haniu, Miyu; Ueda, Katsuya; Ishida, Haruka; Ma, Chuang; Ideta, Hirokazu; Sobajima, Atsushi; Ueshiba, Koki; Uemura, Takeshi; Saito, Naoto; Haniu, Hisao;
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(14), Jul. 2021 - Abundant oleoyl-lysophosphatidylethanolamine in brain stimulates neurite outgrowth and protects against glutamate toxicity in cultured cortical neurons
Hisano, Kazutoshi; Yoshida, Hironori; Kawase, Shiori; Mimura, Tetsuhiko; Yoshida, Hironori;Haniu, Hisao; Tsukahara, Tamotsu; Kurihara, Taiga; Matsuda, Yoshikazu; Saito, Naoto; Uemura, Takeshi;
The Journal of Biochemistry, Apr 5;mvab046., 2021
Last, Corresponding - Structurally different lysophosphatidylethanolamine species stimulate neurite outgrowth in cultured cortical neurons via distinct G-protein-coupled receptors and signaling cascades
Hisano, Kazutoshi; Kawase, Shiori; Mimura, Tetsuhiko; Yoshida, Hironori; Yamada, Hiroki; Haniu, Hisao; Tsukahara, Tamotsu; Kurihara, Taiga; Matsuda, Yoshikazu; Saito, Naoto; Uemura, Takeshi;
Biochemical and biophysical research communications, 534, 179-185, 2021
Last, Corresponding - Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice
Yoshida, Tomoyuki; Yamagata, Atsushi; Imai, Ayako; Kim, Juhyon; Izumi, Hironori; Nakashima, Shogo; Shiroshima, Tomoko; Maeda, Asami; Iwasawa-Okamoto, Shiho; Azechi, Kenji; Osaka, Fumina; Saitoh, Takashi; Maenaka, Katsumi; Shimada, Takashi; Fukata, Yuko; Fukata, Masaki; Matsumoto, Jumpei; Nishijo, Hisao; Takao, Keizo; Tanaka, Shinji; Okabe, Shigeo; Tabuchi, Katsuhiko; Uemura, Takeshi; Mishina, Masayoshi; Mori, Hisashi; Fukai, Shuya;
NATURE COMMUNICATIONS, 12(1), 1848, 2021 - Therapeutic Potential of Porcine Liver Decomposition Product: New Insights and Perspectives for Microglia-Mediated Neuroinflammation in Neurodegenerative Diseases
Tsukahara, Tamotsu; Haniu, Hisao; Uemura, Takeshi; Matsuda, Yoshikazu;
BIOMEDICINES, 8(11), Nov. 2020 - Oral administration of porcine liver decomposition product for 4 weeks enhances visual memory and delayed recall in healthy adults over 40 years of age: A randomized, double-blind, placebo-controlled study
Matsuda, Yoshikazu; Haniu, Hisao; Tsukahara, Tamotsu; Uemura, Takeshi; Inoue, Toshio; Sako, Ken-ichi; Kojima, Jun; Mori, Tatsuro; Sato, Kazusaburou;
EXPERIMENTAL GERONTOLOGY, 141, Nov. 2020 - Cellular Responses of Human Lymphatic Endothelial Cells to Carbon Nanomaterials
Sano, Mahoko; Izumiya, Makoto; Haniu, Hisao; Ueda, Katsuya; Konishi, Kosuke; Ishida, Haruka; Kuroda, Chika; Uemura, Takeshi; Aoki, Kaoru; Matsuda, Yoshikazu; Saito, Naoto;
Nanomaterials, 10(7), Jul. 2020 - Porcine liver decomposition product-derived lysophospholipids promote microglial activation in vitro
Tsukahara Tamotsu;Haniu Hisao;Uemura Takeshi;Matsuda Yoshikazu
SCIENTIFIC REPORTS, 10(1), 28 Feb. 2020
- Anti-PD-1 antibody decreases tumour-infiltrating regulatory T cells
Yoshida, Kazushige; Okamoto, Masanori; Sasaki, Jun; Kuroda, Chika; Ishida, Haruka; Ueda, Katsuya; Ideta, Hirokazu; Kamanaka, Takayuki; Sobajima, Atsushi; Takizawa, Takashi; Tanaka, Manabu; Aoki, Kaoru; Uemura, Takeshi; Kato, Hiroyuki; Haniu, Hisao; Saito, Naoto;
BMC CANCER, 20(1), 2020 - DNA repair protein RAD51 enhances the CRISPR/Cas9-mediated knock-in efficiency in brain neurons
Kurihara, Taiga; Kouyama-Suzuki, Emi; Satoga, Michiru; Li, Xue; Badawi, Moataz; Thiha; Baig, Deeba Noreen; Yanagawa, Toru; Uemura, Takeshi; Mori, Takuma; Tabuchi, Katsuhiko;
Biochemical and biophysical research communications, 524(3), 621-628, 2020 - Specific Neuroligin3-alpha Neurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus
Uchigashima, Motokazu; Konno, Kohtarou; Demchak, Emily; Cheung, Amy; Watanabe, Takuya; Keener, David G.; Abe, Manabu; Le, Timmy; Sakimura, Kenji; Sasaoka, Toshikuni; Uemura, Takeshi; Kawasawa, Yuka Imamura; Watanabe, Masahiko; Futai, Kensuke;
Elife, 9, 2020 - Carbon fibers for treatment of cancer metastasis in bone
Kamanaka, Takayuki; Haniu, Hisao; Tanaka, Manabu; Takizawa, Takashi; Aoki, Kaoru; Okamoto, Masanori; Sobajima, Atsushi; Yoshida, Kazushige; Ideta, Hirokazu; Mimura, Tetsuhiko; Ishida, Haruka; Ueda, Katsuya; Uemura, Takeshi; Kim, Jin Hee; Kim, Yoong Ahm; Kato, Hiroyuki; Saito, Naoto;
RSC Advances, 10(55), 33071-33079, 2020 - Deficiency of calcium/calmodulin-dependent serine protein kinase disrupts the excitatory-inhibitory balance of synapses by downregulating GluN2B (vol 24, pg 1079, 2019)
Mori, Takuma; Kasem, Enas A.; Suzuki-Kouyama, Emi; Cao, Xueshan; Li, Xue; Kurihara, Taiga; Uemura, Takeshi; Yanagawa, Toru; Tabuchi, Katsuhiko;
MOLECULAR PSYCHIATRY, 24(7), 1093-1093, Jul. 2019 - Clinical outcome of osteosarcoma and its correlation with programmed death-ligand 1 and T cell activation markers
Yoshida, Kazushige; Okamoto, Masanori; Sasaki, Jun; Kuroda, Chika; Ishida, Haruka; Ueda, Katsuya; Okano, Satomi; Ideta, Hirokazu; Kamanaka, Takayuki; Sobajima, Atsushi; Takizawa, Takashi; Kito, Munehisa; Aoki, Kaoru; Uemura, Takeshi; Haniu, Hisao; Kato, Hiroyuki; Saito, Naoto;
OncoTargets and Therapy, 12, 2513-2518, 2019 - Structural basis of trans-synaptic interactions between PTPδ and SALMs for inducing synapse formation
Goto-Ito S, Yamagata A, Sato Y, Uemura T, Shiroshima T, Maeda A, Imai A, Mori H, Yoshida T, Fukai
NATURE COMMUNICATIONS, 9, 269, 2018, Refereed
Last, Corresponding - MTSS1 Regulation of Actin-Nucleating Formin DAAM1 in Dendritic Filopodia Determines Final Dendritic Configuration of Purkinje Cells
Kawabata Galbraith K, Fujishima K, Mizuno H, Lee SJ, Uemura T, Sakimura K, Mishina M, Watanabe N, Kengaku M
Cell Rep, 24, 95-106, 2018, Refereed - Structural insights into modulation and selectivity of transsynaptic neurexin-LRRTM interaction
Yamagata, Atsushi; Goto-Ito, Sakurako; Sato, Yusuke; Shiroshima, Tomoko; Maeda, Asami; Watanabe, Masahiko; Saitoh, Takashi; Maenaka, Katsumi; Terada, Tohru; Yoshida, Tomoyuki; Uemura, Takeshi; Fukai, Shuya;
NATURE COMMUNICATIONS, 9, 2018
Corresponding - In situ screening for postsynaptic cell adhesion molecules during synapse formation
Uemura T, Shiroshima T, Maeda A, Yasumura M, Shimada T, Fukata Y, Fukata M, Yoshida T
JOURNAL OF BIOCHEMISTRY, 162, 295-302, 2017, Refereed
Lead, Corresponding - Fluorescent protein tagging of endogenous protein in brain neurons using CRISPR/Cas9-mediated knock-in and in utero electroporation techniques
Uemura, Takeshi; Mori, Takuma; Kurihara, Taiga; Kawase, Shiori; Koike, Rie; Satoga, Michiru; Cao, Xueshan; Li, Xue; Yanagawa, Toru; Sakurai, Takayuki; Shindo, Takayuki; Tabuchi, Katsuhiko;
SCIENTIFIC REPORTS, 6, 2016
Lead, Corresponding - Mechanisms of splicing-dependent trans-synaptic adhesion by PTP delta-IL1RAPL1/IL-1RAcP for synaptic differentiation
Yamagata, Atsushi; Yoshida, Tomoyuki; Sato, Yusuke; Goto-Ito, Sakurako; Uemura, Takeshi; Maeda, Asami; Shiroshima, Tomoko; Iwasawa-Okamoto, Shiho; Mori, Hisashi; Mishina, Masayoshi; Fukai, Shuya;
NATURE COMMUNICATIONS, 6, Apr. 2015 - Structure of Slitrk2-PTP delta complex reveals mechanisms for splicing-dependent trans-synaptic adhesion
Yamagata, Atsushi; Sato, Yusuke; Goto-Ito, Sakurako; Uemura, Takeshi; Maeda, Asami; Shiroshima, Tomoko; Yoshida, Tomoyuki; Fukai, Shuya;
SCIENTIFIC REPORTS, 5, 2015 - Electron microscopy of primary cell cultures in solution and correlative optical microscopy using ASEM
Hirano, Kazumi; Kinoshita, Takaaki; Uemura, Takeshi; Motohashi, Hozumi; Watanabe, Yohei; Ebihara, Tatsuhiko; Nishiyama, Hidetoshi; Sato, Mari; Suga, Mitsuo; Maruyama, Yuusuke; Tsuji, Noriko M.; Yamamoto, Masayuki; Nishihara, Shoko; Sato, Chikara;
ULTRAMICROSCOPY, 143, 52-66, Aug. 2014 - Striatal dopamine D1 receptor is essential for contextual fear conditioning
Ikegami M, Uemura T, Kishioka A, Sakimura K, Mishina M
SCIENTIFIC REPORTS, 4, 3976, 2014 - IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours
Yasumura, Misato; Yoshida, Tomoyuki; Yamazaki, Maya; Abe, Manabu; Natsume, Rie; Kanno, Kouta; Uemura, Takeshi; Takao, Keizo; Sakimura, Kenji; Kikusui, Takefumi; Miyakawa, Tsuyoshi; Mishina, Masayoshi;
SCIENTIFIC REPORTS, 4, 2014 - Striatal dopamine D1 receptor is essential for contextual fear conditioning
Ikegami, Masaru; Uemura, Takeshi; Kishioka, Ayumi; Sakimura, Kenji; Mishina, Masayoshi;
SCIENTIFIC REPORTS, 4, 2014 - Synapse formation in the brain
Mishina M, Yoshida T, Yasumura M, Uemura T
Cortical Development, 282, 229－248, 2013 - Consolidation of auditory fear memories formed by weak unconditioned stimuli requires NMDA receptor activation and de novo protein synthesis in the striatum
Kishioka A, Uemura T, Fukushima F, Mishina M
Mol. Brain, 6, 17, 2013 - Molecular mechanism of parallel fiber-Purkinje cell synapse formation.
Masayoshi Mishina, Takeshi Uemura, Misato Yasumura and Tomoyuki Yoshida
Frontiers in Neural Circuits, 6(90), doi: 10.3389/fncir.2012.00090, 2012, Refereed - GluRδ2 Assembles Four Neurexins into Trans-Synaptic Triad to Trigger Synapse Formation
Lee SJ, Uemura T, Yoshida T, Mishina M
J Neurosci, 32(13), 4688-4701, 2012 - Interleukin-1 Receptor Accessory Protein organizes neuronal synaptogenesis as a cell adhesion molecule
Yoshida T, Shiroshima T, Lee SJ, Yasumura M, Uemura T, Chen X, Iwakura Y, Mishina M
J Neurosci, 32(8), 2588-2600, 2012 - Glutamate receptor δ1 induces preferentially inhibitory presynaptic differentiation of corticalneurons by interacting with neurexins through cerebellin precursor protein subtypes
Yasumura M, Yoshida T, Lee SJ, Uemura T, Joo JY, Mishina M
J Neurochem, 121(5), 705-716, 2012 - IL-1 Receptor Accessory Protein-Like 1 Associated with Mental Retardation and Autism Mediates Synapse Formation by Trans-Synaptic Interaction with Protein Tyrosine Phosphatase δ
Yoshida T, Yasumura M, Uemura T, Lee SJ, Ra M, Taguchi R, Iwakura Y, Mishina M
J Neurosci, 31(88), 13485-13499, 2011 - Differential Interactions of Cerebellin Precursor Protein (Cbln) Subtypes and Neurexin Variants for Synapse Formation of Cortical Neurons
Joo JY, Lee SJ, Uemura T, Yoshida T, Yasumura M, Watanabe M, Mishina M
Biochem Biophys Res Commun, 406(4), 627-632, 2011 - Trans-synaptic interaction of GluRδ2 and neurexin through Cbln1 mediates synapse formation in the cerebellum
Uemura T, Lee SJ, Yasumura M, Takeuchi T, Yoshida T, Ra M, Taguchi R, Sakimura K, Mishina M
Cell, 141(6), 1068-1079, 2010 - The amino-terminal domain of glutamate receptor δ2 triggers presynaptic differentiation
Uemura T, Mishina M
Biochem Biophys Res Commun, 377(4), 1315-1319, 2008 - Role of the internal Shank-binding segment of glutamate receptor δ2 in synaptic localization and cerebellar functions
Yasumura M, Uemura T, Yamasaki M, Sakimura K, Watanabe M, Mishina
Neurosci Lett, 433(2), 146-151, 2008 - Regulation of long-term depression and climbing fiber territory by glutamate receptor δ2 at parallel fiber synapses through its C-terminal domain in cerebellar Purkinje cells
Uemura T, Kakizawa S, Yamasaki M, Sakimura K, WatanabeM, Iino M, Mishina M
J Neurosci, 27(44), 12096-12108, 2007 - Direct interaction of GluRδ2 with Shank scaffold proteins in cerebellar Purkinje cells
Uemura T, Mori H, Mishina M
Mol Cell Neurosci, 26(2), 330-341, 2004 - Molecular visualization of immunoglobulin switch region RNA/DNA complex byatomic force microscope
Mizuta R, Iwai K, Shigeno M, Mizuta M, Uemura T, Ushiki, T, Kitamura D
J Biol Chem, 278(7), 4431-4434, 2003 - Isolation and Characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain
Uemura T, Mori H, Mishina M
Biochem Biophys Res Commun, 296(2), 492-496, 2002
