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UEMURA Takeshi

Academic OrganizationAcademic Assembly School of Humanities and Social Sciences Institute of HumanitiesTEL+81-263-37-3108
Education and Research OrganizationResearch Center for Supports to Advanced Science (RCSAS)FAX
PositionAssociate ProfessorMail Address
AddressWeb sitehttps://www.shinshu-u.ac.jp/institution/kiban/
http://www.shinshu-u.ac.jp/institution/ibs/

Profile

Research Field
Molecular Neuroscience / General neuroscience
Keywords:CNS , synapse , neural circuit formation , neurodevelopmental disorders

Research

Books, Articles, etc.
Books
シナプス形成を誘導する膜受容体の機能と構造
実験医学 増刊 , 32:92-97 2014
Author:深井周也, 植村 健, 吉田知之


シナプスオーガナイザーによるシナプス形成の制御機構
生物物理 , 53:90-93 2013
Author:植村健


シナプス形成とグルタミン酸受容体δ2サブユニット
細胞工学 , 30(2):186-191 2011
Author:植村健, 三品昌美


Articles
Structural insights into modulation and selectivity of transsynaptic neurexin–LRRTM interaction.
Nat. Commun.,9:3964 2018
Author:Yamagata A, Goto-Ito S, Sato Y, Shiroshima T, Maeda A, Watanabe M, Saitoh T, Maenaka K, Terada T, Yoshida T, Uemura T*, Fukai S*


MTSS1 Regulation of Actin-Nucleating Formin DAAM1 in Dendritic Filopodia Determines Final Dendritic Configuration of Purkinje Cells
Cell Rep,24:95-106 2018
Author:Kawabata Galbraith K, Fujishima K, Mizuno H, Lee SJ, Uemura T, Sakimura K, Mishina M, Watanabe N, Kengaku M


Structural basis of trans-synaptic interactions between PTPδ and SALMs for inducing synapse formation
Nature Communications,9:269 2018
Author:Goto-Ito S, Yamagata A, Sato Y, Uemura T, Shiroshima T, Maeda A, Imai A, Mori H, Yoshida T, Fukai


In situ screening for postsynaptic cell adhesion molecules during synapse formation
Journal of Biochemistry,162:295-302 2017
Author:Uemura T, Shiroshima T, Maeda A, Yasumura M, Shimada T, Fukata Y, Fukata M, Yoshida T


Fluorescent protein tagging of endogenous protein in brain neurons using CRISPR/Cas9-mediated knock-in and in utero electroporation techniques
SCIENTIFIC REPORTS,6:- 2016
Author:Uemura, Takeshi; Mori, Takuma; Kurihara, Taiga; Kawase, Shiori; Koike, Rie; Satoga, Michiru; Cao, Xueshan; Li, Xue; Yanagawa, Toru; Sakurai, Takayuki; Shindo, Takayuki; Tabuchi, Katsuhiko;


Mechanisms of splicing-dependent trans-synaptic adhesion by PTP delta-IL1RAPL1/IL-1RAcP for synaptic differentiation
NATURE COMMUNICATIONS,6:- 2015(Apr.)
Author:Yamagata, Atsushi; Yoshida, Tomoyuki; Sato, Yusuke; Goto-Ito, Sakurako; Uemura, Takeshi; Maeda, Asami; Shiroshima, Tomoko; Iwasawa-Okamoto, Shiho; Mori, Hisashi; Mishina, Masayoshi; Fukai, Shuya;


Structure of Slitrk2-PTP delta complex reveals mechanisms for splicing-dependent trans-synaptic adhesion
SCIENTIFIC REPORTS,5:- 2015
Author:Yamagata, Atsushi; Sato, Yusuke; Goto-Ito, Sakurako; Uemura, Takeshi; Maeda, Asami; Shiroshima, Tomoko; Yoshida, Tomoyuki; Fukai, Shuya;


Electron microscopy of primary cell cultures in solution and correlative optical microscopy using ASEM
ULTRAMICROSCOPY,143:52-66 2014(Aug.)
Author:Hirano, Kazumi; Kinoshita, Takaaki; Uemura, Takeshi; Motohashi, Hozumi; Watanabe, Yohei; Ebihara, Tatsuhiko; Nishiyama, Hidetoshi; Sato, Mari; Suga, Mitsuo; Maruyama, Yuusuke; Tsuji, Noriko M.; Yamamoto, Masayuki; Nishihara, Shoko; Sato, Chikara;


Striatal dopamine D1 receptor is essential for contextual fear conditioning
SCIENTIFIC REPORTS,4:- 2014
Author:Ikegami, Masaru; Uemura, Takeshi; Kishioka, Ayumi; Sakimura, Kenji; Mishina, Masayoshi;


IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours
SCIENTIFIC REPORTS,4:- 2014
Author:Yasumura, Misato; Yoshida, Tomoyuki; Yamazaki, Maya; Abe, Manabu; Natsume, Rie; Kanno, Kouta; Uemura, Takeshi; Takao, Keizo; Sakimura, Kenji; Kikusui, Takefumi; Miyakawa, Tsuyoshi; Mishina, Masayoshi;


Striatal dopamine D1 receptor is essential for contextual fear conditioning
Scientific Reports,4:3976 2014
Author:Ikegami M, Uemura T, Kishioka A, Sakimura K, Mishina M


Synapse formation in the brain
Cortical Development,282:229-248 2013
Author:Mishina M, Yoshida T, Yasumura M, Uemura T


Consolidation of auditory fear memories formed by weak unconditioned stimuli requires NMDA receptor activation and de novo protein synthesis in the striatum
Mol. Brain,6:17 2013
Author:Kishioka A, Uemura T, Fukushima F, Mishina M


Glutamate receptor δ1 induces preferentially inhibitory presynaptic differentiation of corticalneurons by interacting with neurexins through cerebellin precursor protein subtypes
J Neurochem,121(5):705-716 2012
Author:Yasumura M, Yoshida T, Lee SJ, Uemura T, Joo JY, Mishina M


Interleukin-1 Receptor Accessory Protein organizes neuronal synaptogenesis as a cell adhesion molecule
J Neurosci,32(8):2588-2600 2012
Author:Yoshida T, Shiroshima T, Lee SJ, Yasumura M, Uemura T, Chen X, Iwakura Y, Mishina M


GluRδ2 Assembles Four Neurexins into Trans-Synaptic Triad to Trigger Synapse Formation
J Neurosci,32(13):4688-4701 2012
Author:Lee SJ, Uemura T, Yoshida T, Mishina M


Molecular mechanism of parallel fiber-Purkinje cell synapse formation.
Frontiers in Neural Circuits,6(90):doi: 10.3389/fncir.2012.00090 2012
Author:Masayoshi Mishina, Takeshi Uemura, Misato Yasumura and Tomoyuki Yoshida


Differential Interactions of Cerebellin Precursor Protein (Cbln) Subtypes and Neurexin Variants for Synapse Formation of Cortical Neurons
Biochem Biophys Res Commun,406(4):627-632 2011
Author:Joo JY, Lee SJ, Uemura T, Yoshida T, Yasumura M, Watanabe M, Mishina M


IL-1 Receptor Accessory Protein-Like 1 Associated with Mental Retardation and Autism Mediates Synapse Formation by Trans-Synaptic Interaction with Protein Tyrosine Phosphatase δ
J Neurosci,31(88):13485-13499 2011
Author:Yoshida T, Yasumura M, Uemura T, Lee SJ, Ra M, Taguchi R, Iwakura Y, Mishina M


Trans-synaptic interaction of GluRδ2 and neurexin through Cbln1 mediates synapse formation in the cerebellum
Cell,141(6):1068-1079 2010
Author:Uemura T, Lee SJ, Yasumura M, Takeuchi T, Yoshida T, Ra M, Taguchi R, Sakimura K, Mishina M


Role of the internal Shank-binding segment of glutamate receptor δ2 in synaptic localization and cerebellar functions
Neurosci Lett,433(2):146-151 2008
Author:Yasumura M, Uemura T, Yamasaki M, Sakimura K, Watanabe M, Mishina


The amino-terminal domain of glutamate receptor δ2 triggers presynaptic differentiation
Biochem Biophys Res Commun,377(4):1315-1319 2008
Author:Uemura T, Mishina M


Regulation of long-term depression and climbing fiber territory by glutamate receptor δ2 at parallel fiber synapses through its C-terminal domain in cerebellar Purkinje cells
J Neurosci,27(44):12096-12108 2007
Author:Uemura T, Kakizawa S, Yamasaki M, Sakimura K, WatanabeM, Iino M, Mishina M


Direct interaction of GluRδ2 with Shank scaffold proteins in cerebellar Purkinje cells
Mol Cell Neurosci,26(2):330-341 2004
Author:Uemura T, Mori H, Mishina M


Molecular visualization of immunoglobulin switch region RNA/DNA complex byatomic force microscope
J Biol Chem,278(7):4431-4434 2003
Author:Mizuta R, Iwai K, Shigeno M, Mizuta M, Uemura T, Ushiki, T, Kitamura D


Isolation and Characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain
Biochem Biophys Res Commun,296(2):492-496 2002
Author:Uemura T, Mori H, Mishina M