博士(医学), 信州大学医学部病理組織学講座

Medical biochemistry, General medical chemistry

Experimental pathology, Experimental pathology

Bacteriology, Microbiology

Cholestenone functions as an antibiotic against Helicobacter pylori by inhibiting biosynthesis of the cell wall component CGL
Kobayashi, Junichi; Kawakubo, Masatomo; Fujii, Chifumi; Arisaka, Nobuhiko; Miyashita, Masaki; Sato, Yoshiko; Komura, Hitomi; Matoba, Hisanori; Nakayama, Jun;
Proceedings of the National Academy of Sciences of the United States of America, 118(16), 2021

Cecal Tumorigenesis in Aryl Hydrocarbon Receptor-Deficient Mice Depends on Cecum-Specific Mitogen-Activated Protein Kinase Pathway Activation and Inflammation
Matoba, Hisanori; Takamoto, Masaya; Fujii, Chifumi; Kawakubo, Masatomo; Kasuga, Eriko; Matsumura, Tomio; Natori, Tatsuya; Misawa, Ken; Taniguchi, Shun'ichiro; Nakayama, Jun;
AMERICAN JOURNAL OF PATHOLOGY, 190(2), 453-468, Feb. 2020

Analysis of A4gnt knockout mice reveals an essential role for gastric sulfomucins in preventing gastritis cystica profunda.
Kawakubo M, Komura H, Goso Y, Okumura M, Sato Y, Fujii C, Miyashita M, Arisaka N, Harumiya S, Yamanoi K, Yamada S, Kakuta S, Kawashima H, Fukuda MN, Fukuda M, Nakayama J
J Histochem Cytochem, 67, 759-770, Jun. 2019, Refereed

The relationship between acrolein and oxidative stress in COPD: in systemic plasma and in local lung tissue.
Yasuo M, Droma Y, Kitaguchi Y, Ito M, Imamura H, Kawakubo M, Hanaoka M
Int J Chron Obstruct Pulmon Dis, 14, 1527-1537, 2019, Refereed

Cholesterol--glucosyltransferase gene is present in most Helicobacter species including gastric non-Helicobacter pylori helicobacters obtained from Japanese patients
Kawakubo, Masatomo; Horiuchi, Kazuki; Matsumoto, Takehisa; Nakayama, Jun; Akamatsu, Taiji; Katsuyama, Tsutomu; Ota, Hiroyoshi; Sagara, Junji;
HELICOBACTER, 23(1), Feb. 2018

Cloning of Helicobacter suis cholesterol alpha-glucosyltransferase and production of an antibody capable of detecting it in formalin-fixed, paraffin-embedded gastric tissue sections
Kawakubo, Masatomo; Horiuchi, Kazuki; Komura, Hitomi; Sato, Yoshiko; Kato, Masayoshi; Ikeyama, Meguru; Fukushima, Mana; Yamada, Shigenori; Ishizone, Satoshi; Matsumoto, Takehisa; Ota, Hiroyoshi; Sagara, Junji; Nakayama, Jun;
HISTOCHEMISTRY AND CELL BIOLOGY, 148(4), 463-471, Oct. 2017, Refereed

High expression of ADAM10 predicts a poor prognosis for patients with glioblastoma
Kanaya K, Sakai K, Hongo K, Fukushima M, Kawakubo M, Nakayama J
Int J Clin Exp Pathol, 10, 618-624, Jan. 2017

Targeted drug delivery to brain tumor vasculature by carbohydrate mimetic peptide in mouse glioma model
Suzuki-Anekoji, Misa; Yeh, Jiunn-Chern; Kawakubo, Masatomo; Nonaka, Motohiro; Shibata, Toshiaki K.; Sugihara, Kazuhiro; Nakayama, Jun; Fukuda, Minoru; Fukuda, Michiko N.;
GLYCOBIOLOGY, 24(11), 1104-1105, Nov. 2014

Development of New PCR Primers by Comparative Genomics for the Detection of Helicobacter suis in Gastric Biopsy Specimens
Matsui, Hidenori; Takahashi, Tetsufumi; Murayama, Somay Y.; Uchiyama, Ikuo; Yamaguchi, Katsushi; Shigenobu, Shuji; Matsumoto, Takehisa; Kawakubo, Masatomo; Horiuchi, Kazuki; Ota, Hiroyoshi; Osaki, Takako; Kamiya, Shigeru; Smet, Annemieke; Flahou, Bram; Ducatelle, Richard; Haesebrouck, Freddy; Takahashi, Shinichi; Nakamura, Shinichi; Nakamura, Masahiko;
HELICOBACTER, 19(4), 260-271, Aug. 2014

Helicobacter heilmannii sensu stricto-related gastric ulcers: a case report
Matsumoto T, Kawakubo M, Akamatsu T他７名
World J Gastroenterol, 20(12), 3376-3382, May 2014

Overexpression of O-ClcNAc by prostate cancer cells is significantly associated with poor prognosis of patients.
Kamigaito T, Okaneya T, Kawakubo M, Shimojo H, Nishizawa O, Nakayama J
Prostate Cancer Prostatic Dis, 2013

Carbon nanotubes induce bone calcification by bidirectional interaction with osteoblasts.
Shimizu M, Kobayashi Y, Mizoguchi T, Nakamura H, Kawahara I, Narita N, Usui Y, Aoki K, Hara K, Haniu H, Ogihara N, Ishigaki N, Nakamura K, Kato H, Kawakubo M, Dohi Y, Taruta S, Kim YA, Endo M, Ozawa H, Udagawa N, Takahashi N, Saito N
Adv Mater, 24, 2176-2185, 2012, Refereed

Defence mechanism against Helicobacter pylori infection mediated by gastric mucous carbohydrate.
川久保雅友，中山淳
医学のあゆみ, 241(2), 160, 2012

Vimentin and desmin possess GlcNAc-binding lectin-like properties on cell surfaces
Ise, Hirohiko; Kobayashi, Satoshi; Goto, Mitsuaki; Sato, Takao; Kawakubo, Masatomo; Takahashi, Masafumi; Ikeda, Uichi; Akaike, Toshihiro;
GLYCOBIOLOGY, 20(7), 843-864, Jul. 2010

Serum fragmented cytokeratin 18 levels reflect the histologic activity score of nonalcoholic fatty liver disease more accurately than serum alanine aminotransferase levels.
Tsutsui M, Tanaka N, Kawakubo M, Sheena Y, Horiuchi A, Komatsu M, Nagaya T, Joshita S, Umemura T, Ichijo T, Matsumoto A, Yoshizawa K, Aoyama T, Tanaka E, Sano K
J Clin Gastroenterol, 44, 440-447, 2010

Induction of high endothelial venule-like vessels expressing GlcNAc6ST-1-mediated L-selectin ligand carbohydrate and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) in a mouse model of "Candidatus Helicobacter heilmannii"-induced gastritis and gastric mucosa-associated lymphoid tissue (MALT) lymphoma.
Suzuki A, Kobayashi M, Matsuda K, Matsumoto T, Kawakubo M, Kumazawa S, Koide N, Miyagawa S, Ota H
HELICOBACTER, 15, 538-548, 2010

Phylogeny of a novel "Helicobacter heilmannii" organism from a Japanese patient with chronic gastritis based on DNA sequence analysis of 16S rRNA and urease genes.
Matsumoto T, Kawakubo M, Shiohara M, Kumagai T, Hidaka E, Yamauchi K, Oana K, Matsuzawa K, Ota H, Kawakami Y
J Microbiol, 47, 201-207, 2009

Laboratory appraisal of optimal gaseous conditions for growth of zoonotic Helicobacter felis ATCC 49179.
Shiohara M, Kawakubo M, Matsumoto T, Kumagai T, Yamauchi K, Oana K, Ota H, Kawakami Y
Microbiol Immunol, 53, 251-258, 2009

Role of ASC in the mouse model of Helicobacter pylori infection.
Benoit BN, Kobayashi M, Kawakubo M, Takeoka M, Sano K, Zou J, Itano N, Tsutsui H, Noda T, Fukuda M, Nakayama J, Taniguchi S
J Histochem Cytochem, 57, 327-338, 2009

Hyperproduction of hyaluronan in Neu-induced mammary tumor accelerates angiogenesis through stromal cell recruitment - Possible involvement of versican/PG-M
Koyama, Hiroshi; Hibi, Terumasa; Isogai, Zenzo; Yoneda, Masahiko; Fujimori, Minoru; Amano, Jun; Kawakubo, Masatomo; Kannagi, Reiji; Kimata, Koji; Taniguchi, Shun'ichiro; Itano, Naoki;
AMERICAN JOURNAL OF PATHOLOGY, 170(3), 1086-1099, Mar. 2007

RNA interference-mediated knock-down of transient receptor potential vanilloid 1 prevents forepaw inflammatory hyperalgesia in rat.
Kasama S, Kawakubo M, Suzuki T, Nishizawa T, Ishida A, Nakayama J
Eur J Neurosci, 25(10), 2956-2963, 2007

Assay of human gastric mucin as a natural antibiotic against Helicobacter pylori.
Fukuda M, Kawakubo M, Ito Y, Kobayashi M, Lee H, Nakayama J
Methods Enzymol, 415, 164-179, 2006

A locus for eosinophilia in the MES rat is on Chromosome 19
Li G, Guo Z, Higuchi K, Kawakubo M, Matsumoto K, Mori M
Mamm Genome, 16(7), 516-523, 2005

Expression of Fas ligand by hepatic macrophages in patients with fulminant hepatic failure.
Mita A, Hashikura Y, Tagawa Y, Nakayama J, Kawakubo M, Miyagawa S
Am J Gastroenterol, 100(11), 2551-2559, 2005

Haematological data for Matsumoto Eosinophilic Shinshu rats as determined by an automated haematology analyser
Muto S, Kawakubo M, Matsushita N, Maeda N, Momose Y, Matsumoto K
Lab Anim-UK, 391(1), 122-129, 2005

Glycan associated with H. pylori infection.
川久保 雅友
臨床微生物迅速診断研究会誌, 16(2), 173-177, 2005

Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection.
Kawakubo M, Ito Y, Okimura Y, Kobayashi M, Sakura K, Kasama S, Fukuda MN, Fukuda M, Katsuyama T, Nakayama J
science, 305(5686), 1003-1006, 2004, Refereed

Usefulness of the real-time reverse transcription-polymerase chain reaction assay targeted to α1,4-N-acetylglucosaminyltransferase for the detection of gastric cancer.
Shimizu F, Nakayama J, Ishizone S, Zhang MX, Kawakubo M, Ota H, Sugiyama A, Kawasaki S, Fukuda M, Katsuyama T
Lab Invest, 83(2), 187-197, 2003

Differential expression of ribosomal proteins in human normal and neoplastic colorectum.
Kasai H, Nadano D, Hidaka E, Higuchi K, Kawakubo M, Sato TA, Nakayama J
Histochem Cytochem, 51(5), 567-574, 2003

Antigenicity Study of CG-101.
Momose Y, Isaka T, Isaji M, Kawakubo M, Shibata N, Endo Y, Hatsuoka M
薬理と臨床, 64(4), 815-825, 1996

The application of industrial endoscope to observation of the ocular-fundus in small laboratory animals.
Kiyosawa I, Aruga N, Kawakubo M, Naito J, Saito TR, Takahashi KW
実験動物, 41(1), 67-70, 1992

Glycoscience: Biology and Medicine
Joint work
Springer Japan, 723-729 Jan. 2015

Analysis of A4gnt Knockout Mice Reveals an Essential Role for Gastric Sulfomucins in Preventing Gastritis Cystica Profunda
Kawakubo M, Komura H, Goso Y, Okumura M, Sato Y, Fujii C, Miyashita M, Arisaka N, Harumiya S, Yamanoi K, Yamada S, Kakuta S, Kawashima H, Fukuda MN, Fukuda M, Nakayama J
第60回日本組織細胞化学会総会・学術集会, 19 Sep. 2019, 日本組織細胞化学会

Targeted drug delivery to brain tumor vasculature by carbohydrate mimetic peptide in mouse glioma model
Suzuki-Anekoji, Misa; Yeh, Jiunn-Chern; Kawakubo, Masatomo; Nonaka, Motohiro; Shibata, Toshiaki K.; Sugihara, Kazuhiro; Nakayama, Jun; Fukuda, Minoru; Fukuda, Michiko N.;
GLYCOBIOLOGY 24 11 1104-1105, Nov. 2014

Jun. 2013
Japan society of histochemistry and cytochemistry